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Aliases for BCAS2 Gene

Aliases for BCAS2 Gene

  • Breast Carcinoma Amplified Sequence 2 2 3
  • DAM1 3 4 6
  • DNA Amplified In Mammary Carcinoma 1 Protein 3 4
  • Breast Carcinoma-Amplified Sequence 2 3 4
  • Spliceosome-Associated Protein SPF 27 3 4
  • Spliceosome Associated Protein, Amplified In Breast Cancer 3
  • Pre-MRNA-Splicing Factor SPF27 3
  • Snt309 3
  • SPF27 3

External Ids for BCAS2 Gene

Summaries for BCAS2 Gene

GeneCards Summary for BCAS2 Gene

BCAS2 (Breast Carcinoma Amplified Sequence 2) is a Protein Coding gene. Diseases associated with BCAS2 include breast cancer. Among its related pathways are Spliceosome.

UniProtKB/Swiss-Prot for BCAS2 Gene

  • Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

Gene Wiki entry for BCAS2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAS2 Gene

Genomics for BCAS2 Gene

Genomic Location for BCAS2 Gene

Start:
114,567,557 bp from pter
End:
114,581,644 bp from pter
Size:
14,088 bases
Orientation:
Minus strand

Genomic View for BCAS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCAS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAS2 Gene

Regulatory Elements for BCAS2 Gene

Proteins for BCAS2 Gene

  • Protein details for BCAS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75934-SPF27_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor SPF27
    Protein Accession:
    O75934
    Secondary Accessions:
    • Q6FGS0

    Protein attributes for BCAS2 Gene

    Size:
    225 amino acids
    Molecular mass:
    26131 Da
    Quaternary structure:
    • Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly in the complex with PRPF19, CDC5L and PLRG1.

neXtProt entry for BCAS2 Gene

Proteomics data for BCAS2 Gene at MOPED

Post-translational modifications for BCAS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCAS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BCAS2 Gene

Domains for BCAS2 Gene

Protein Domains for BCAS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BCAS2 Gene

Graphical View of Domain Structure for InterPro Entry

O75934

UniProtKB/Swiss-Prot:

SPF27_HUMAN
Family:
  • Belongs to the SPF27 family.:
    • O75934
genes like me logo Genes that share domains with BCAS2: view

No data available for Gene Families for BCAS2 Gene

Function for BCAS2 Gene

Molecular function for BCAS2 Gene

GENATLAS Biochemistry: breast carcinoma amplified sequence 2,possible homolog of C elegans T12A2.7 protein,spliceosome associated protein
UniProtKB/Swiss-Prot Function: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

Gene Ontology (GO) - Molecular Function for BCAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20176811
genes like me logo Genes that share ontologies with BCAS2: view

Phenotypes for BCAS2 Gene

genes like me logo Genes that share phenotypes with BCAS2: view

miRNA for BCAS2 Gene

miRTarBase miRNAs that target BCAS2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BCAS2 Gene

Localization for BCAS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCAS2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCAS2 Gene COMPARTMENTS Subcellular localization image for BCAS2 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for BCAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005662 colocalizes_with DNA replication factor A complex IDA 24332808
GO:0005681 spliceosomal complex IDA 12169396
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with BCAS2: view

Pathways for BCAS2 Gene

SuperPathways for BCAS2 Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with BCAS2: view

Pathways by source for BCAS2 Gene

1 KEGG pathway for BCAS2 Gene

Gene Ontology (GO) - Biological Process for BCAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions TAS 9731529
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing --
GO:0008380 RNA splicing TAS 9731529
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with BCAS2: view

Transcripts for BCAS2 Gene

mRNA/cDNA for BCAS2 Gene

Unigene Clusters for BCAS2 Gene

Breast carcinoma amplified sequence 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCAS2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2:
SP3: -
SP4: - -
SP5: -

Relevant External Links for BCAS2 Gene

GeneLoc Exon Structure for
BCAS2
ECgene alternative splicing isoforms for
BCAS2

Expression for BCAS2 Gene

mRNA expression in normal human tissues for BCAS2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCAS2 Gene

SOURCE GeneReport for Unigene cluster for BCAS2 Gene Hs.22960

mRNA Expression by UniProt/SwissProt for BCAS2 Gene

O75934-SPF27_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with BCAS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BCAS2 Gene

Orthologs for BCAS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BCAS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCAS2 35
  • 99.85 (n)
  • 100 (a)
BCAS2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 97 (a)
OneToMany
BCAS2 35
  • 92.3 (n)
  • 98.22 (a)
BCAS2 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia BCAS2 35
  • 92.89 (n)
  • 98.67 (a)
BCAS2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcas2 35
  • 89.04 (n)
  • 100 (a)
Bcas2 16
Bcas2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCAS2 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCAS2 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcas2 35
  • 88.74 (n)
  • 99.11 (a)
chicken
(Gallus gallus)
Aves BCAS2 35
  • 76.59 (n)
  • 93.78 (a)
BCAS2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCAS2 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25686 35
tropical clawed frog
(Silurana tropicalis)
Amphibia bcas2 35
  • 74.55 (n)
  • 87.27 (a)
MGC75758 35
zebrafish
(Danio rerio)
Actinopterygii bcas2 35
bcas2 35
  • 73.33 (n)
  • 82.67 (a)
bcas2 36
  • 83 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002305 35
  • 59.55 (n)
  • 60.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4980 35
  • 56.63 (n)
  • 59.71 (a)
CG4980 36
  • 45 (a)
OneToOne
CG4980 37
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea T12A2.7 35
  • 50.41 (n)
  • 39.41 (a)
T12A2.7 36
  • 33 (a)
OneToOne
T12A2.7 37
  • 39 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MOS4 35
  • 44.5 (n)
  • 31.1 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4859 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9332 36
  • 66 (a)
OneToOne
Species with no ortholog for BCAS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BCAS2 Gene

ENSEMBL:
Gene Tree for BCAS2 (if available)
TreeFam:
Gene Tree for BCAS2 (if available)

Paralogs for BCAS2 Gene

Pseudogenes.org Pseudogenes for BCAS2 Gene

genes like me logo Genes that share paralogs with BCAS2: view

No data available for Paralogs for BCAS2 Gene

Variants for BCAS2 Gene

Sequence variations from dbSNP and Humsavar for BCAS2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8128 -- 114,568,062(-) GAACT(G/T)TGAAG utr-variant-3-prime
rs10251 -- 114,583,179(-) GTTAA(G/T)CAGGT upstream-variant-2KB
rs1238890 -- 114,573,160(-) AGGTA(A/G)AGGCC intron-variant
rs1564824 -- 114,581,126(-) TCTTA(C/T)TCTAA intron-variant
rs1801890 -- 114,581,326(-) TACCT(A/G)ACAGC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for BCAS2 Gene

Variant ID Type Subtype PubMed ID
esv28734 CNV Loss 19812545
nsv831104 CNV Loss 17160897

Relevant External Links for BCAS2 Gene

HapMap Linkage Disequilibrium report
BCAS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCAS2 Gene

Disorders for BCAS2 Gene

(1) MalaCards Diseases for BCAS2 Gene

Search for BCAS2 Gene in MalaCards »
genes like me logo Genes that share disorders with BCAS2: view

No data available for UniProtKB/Swiss-Prot for BCAS2 Gene

Publications for BCAS2 Gene

  1. Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. (PMID: 9731529) Neubauer G. … Mann M. (Nat. Genet. 1998) 2 3 4
  2. Identification of a novel gene, DAM1, amplified at chromosome 1p13.3- 21 region in human breast cancer cell lines. (PMID: 10403562) Nagasaki K. … Yamaguchi K. (Cancer Lett. 1999) 2 3 4
  3. Amplification of the BCAS2 gene at chromosome 1p13.3-21 in human primary breast cancer. (PMID: 12169396) Maass N. … Nagasaki K. (Cancer Lett. 2002) 3 4
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for BCAS2 Gene

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