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Aliases for BCAS1 Gene

Aliases for BCAS1 Gene

  • Breast Carcinoma Amplified Sequence 1 2 3 5
  • Amplified And Overexpressed In Breast Cancer 3 4
  • Novel Amplified In Breast Cancer 1 3 4
  • AIBC1 3 4
  • NABC1 3 4

External Ids for BCAS1 Gene

Previous GeneCards Identifiers for BCAS1 Gene

  • GC20M052288
  • GC20M053198
  • GC20M053245
  • GC20M051993
  • GC20M052553
  • GC20M049306

Summaries for BCAS1 Gene

Entrez Gene Summary for BCAS1 Gene

  • This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene. [provided by RefSeq, Apr 2016]

GeneCards Summary for BCAS1 Gene

BCAS1 (Breast Carcinoma Amplified Sequence 1) is a Protein Coding gene. Diseases associated with BCAS1 include Breast Cancer.

Gene Wiki entry for BCAS1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAS1 Gene

Genomics for BCAS1 Gene

Regulatory Elements for BCAS1 Gene

Enhancers for BCAS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BCAS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BCAS1 Gene

53,936,777 bp from pter
54,070,765 bp from pter
133,989 bases
Minus strand

Genomic View for BCAS1 Gene

Genes around BCAS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCAS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAS1 Gene

Proteins for BCAS1 Gene

  • Protein details for BCAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Breast carcinoma-amplified sequence 1
    Protein Accession:
    Secondary Accessions:
    • A0AVG5
    • Q68CZ3

    Protein attributes for BCAS1 Gene

    584 amino acids
    Molecular mass:
    61709 Da
    Quaternary structure:
    • Homodimer. May interact with DYNLL1 and DYNLL2 (By similarity).

    Alternative splice isoforms for BCAS1 Gene


neXtProt entry for BCAS1 Gene

Proteomics data for BCAS1 Gene at MOPED

Post-translational modifications for BCAS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCAS1 Gene

Antibody Products

  • Abcam antibodies for NABC1

No data available for DME Specific Peptides for BCAS1 Gene

Domains & Families for BCAS1 Gene

Protein Domains for BCAS1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BCAS1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BCAS1 Gene

Function for BCAS1 Gene

Molecular function for BCAS1 Gene

GENATLAS Biochemistry:
novel sequence amplified and overexpressed in breast cancer
genes like me logo Genes that share phenotypes with BCAS1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCAS1 Gene

Localization for BCAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCAS1 Gene


Subcellular locations from

Jensen Localization Image for BCAS1 Gene COMPARTMENTS Subcellular localization image for BCAS1 gene
Compartment Confidence
extracellular 5
cytosol 2
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for BCAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with BCAS1: view

Pathways & Interactions for BCAS1 Gene

SuperPathways for BCAS1 Gene

No Data Available

Interacting Proteins for BCAS1 Gene

Gene Ontology (GO) - Biological Process for BCAS1 Gene


No data available for Pathways by source and SIGNOR curated interactions for BCAS1 Gene

Drugs & Compounds for BCAS1 Gene

No Compound Related Data Available

Transcripts for BCAS1 Gene

Unigene Clusters for BCAS1 Gene

Breast carcinoma amplified sequence 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCAS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: -

Relevant External Links for BCAS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCAS1 Gene

mRNA expression in normal human tissues for BCAS1 Gene

mRNA differential expression in normal tissues according to GTEx for BCAS1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x16.3), Brain - Substantia nigra (x6.5), Brain - Putamen (basal ganglia) (x4.7), Brain - Amygdala (x4.5), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for BCAS1 Gene

This gene is overexpressed in Nasal epithelium (41.0), Spinal cord (13.9), and Frontal cortex (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BCAS1 Gene

SOURCE GeneReport for Unigene cluster for BCAS1 Gene Hs.400556

mRNA Expression by UniProt/SwissProt for BCAS1 Gene

Tissue specificity: Expressed in brain and prostate, and at lower levels in testis, intestine and colon. Overexpressed in most breast cancer cell lines and down-regulated in some colorectal tumors.
genes like me logo Genes that share expression patterns with BCAS1: view

Primer Products

No data available for Protein tissue co-expression partners for BCAS1 Gene

Orthologs for BCAS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCAS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BCAS1 35
  • 80.2 (n)
  • 76.14 (a)
BCAS1 36
  • 64 (a)
(Canis familiaris)
Mammalia BCAS1 35
  • 83.63 (n)
  • 75.7 (a)
BCAS1 36
  • 77 (a)
(Mus musculus)
Mammalia Bcas1 35
  • 75.51 (n)
  • 64.57 (a)
Bcas1 16
Bcas1 36
  • 57 (a)
(Pan troglodytes)
Mammalia BCAS1 35
  • 99.37 (n)
  • 99.32 (a)
BCAS1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Bcas1 35
  • 76.4 (n)
  • 66.15 (a)
(Monodelphis domestica)
Mammalia BCAS1 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia BCAS1 36
  • 46 (a)
(Gallus gallus)
Aves BCAS1 35
  • 57.65 (n)
  • 43.92 (a)
BCAS1 36
  • 37 (a)
(Anolis carolinensis)
Reptilia BCAS1 36
  • 32 (a)
Species with no ortholog for BCAS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCAS1 Gene

Gene Tree for BCAS1 (if available)
Gene Tree for BCAS1 (if available)

Paralogs for BCAS1 Gene

No data available for Paralogs for BCAS1 Gene

Variants for BCAS1 Gene

Sequence variations from dbSNP and Humsavar for BCAS1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6022903 - 53,996,010(+) CAGTT(C/T)CAAGT reference, missense
rs394732 - 54,058,649(+) TACCT(C/G/T)GTAAG reference, missense
rs158551 - 54,028,627(-) CAAGG(C/T)CCTCT reference, missense
rs1055246 - 53,944,930(-) GCAAA(C/T)CCAAG reference, missense
rs35575210 - 53,957,432(-) TGCCA(A/C)GTAAG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for BCAS1 Gene

Variant ID Type Subtype PubMed ID
esv34060 CNV Loss 18971310
dgv66n68 CNV Loss 17160897
nsv820262 CNV Loss 19587683
esv25594 CNV Loss 19812545
nsv3419 CNV Loss 18451855
esv2465974 CNV Insertion 19546169
esv268120 CNV Insertion 20981092
esv2663008 CNV Deletion 23128226
nsv437187 CNV Loss 16327808
nsv527711 CNV Loss 19592680
dgv4579n71 CNV Loss 21882294
nsv517164 CNV Gain+Loss 19592680
esv2663949 CNV Deletion 23128226
esv2722548 CNV Deletion 23290073
esv23291 CNV Loss 19812545
nsv514943 CNV Loss 21397061
esv2421391 CNV Deletion 20811451
nsv442485 CNV CNV 18776908
dgv513n27 CNV Loss 19166990
nsv817899 CNV Loss 17921354
nsv433324 CNV Loss 18776910
nsv179659 CNV Loss 16902084
dgv1335e1 CNV Complex 17122850
nsv912944 CNV Loss 21882294

Variation tolerance for BCAS1 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.61; 89.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BCAS1 Gene

Disorders for BCAS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BCAS1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search BCAS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BCAS1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BCAS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCAS1 Gene

Publications for BCAS1 Gene

  1. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. (PMID: 9671742) Collins C. … Gray J.W. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23 67
  2. Characterization of the novel amplified in breast cancer-1 (NABC1) gene product. (PMID: 14567997) Beardsley D.I. … Brown K.D. (Exp. Cell Res. 2003) 3 23
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 3

Products for BCAS1 Gene

Sources for BCAS1 Gene