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Aliases for BCAS1 Gene

Aliases for BCAS1 Gene

  • Breast Carcinoma Amplified Sequence 1 2 3
  • NABC1 3 4 6
  • Amplified And Overexpressed In Breast Cancer 3 4
  • Novel Amplified In Breast Cancer 1 3 4
  • AIBC1 3 4
  • Breast Carcinoma-Amplified Sequence 1 3

External Ids for BCAS1 Gene

Summaries for BCAS1 Gene

Entrez Gene Summary for BCAS1 Gene

  • This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCAS1 Gene

BCAS1 (Breast Carcinoma Amplified Sequence 1) is a Protein Coding gene. Diseases associated with BCAS1 include breast cancer.

Gene Wiki entry for BCAS1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAS1 Gene

Genomics for BCAS1 Gene

Genomic Location for BCAS1 Gene

Start:
53,936,777 bp from pter
End:
54,070,765 bp from pter
Size:
133,989 bases
Orientation:
Minus strand

Genomic View for BCAS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAS1 Gene

Regulatory Elements for BCAS1 Gene

Proteins for BCAS1 Gene

  • Protein details for BCAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75363-BCAS1_HUMAN
    Recommended name:
    Breast carcinoma-amplified sequence 1
    Protein Accession:
    O75363
    Secondary Accessions:
    • A0AVG5
    • Q68CZ3

    Protein attributes for BCAS1 Gene

    Size:
    584 amino acids
    Molecular mass:
    61709 Da
    Quaternary structure:
    • Homodimer. May interact with DYNLL1 and DYNLL2 (By similarity).

    Alternative splice isoforms for BCAS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCAS1 Gene

Proteomics data for BCAS1 Gene at MOPED

Post-translational modifications for BCAS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCAS1 Gene

No data available for DME Specific Peptides for BCAS1 Gene

Domains for BCAS1 Gene

Protein Domains for BCAS1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with BCAS1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BCAS1 Gene

Function for BCAS1 Gene

Molecular function for BCAS1 Gene

GENATLAS Biochemistry: novel sequence amplified and overexpressed in breast cancer

Phenotypes for BCAS1 Gene

genes like me logo Genes that share phenotypes with BCAS1: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BCAS1 Gene

Localization for BCAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCAS1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCAS1 Gene COMPARTMENTS Subcellular localization image for BCAS1 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for BCAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with BCAS1: view

Pathways for BCAS1 Gene

SuperPathways for BCAS1 Gene

No Data Available

Interacting Proteins for BCAS1 Gene

Gene Ontology (GO) - Biological Process for BCAS1 Gene

None

No data available for Pathways by source for BCAS1 Gene

Transcripts for BCAS1 Gene

Unigene Clusters for BCAS1 Gene

Breast carcinoma amplified sequence 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCAS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5:
SP6:
SP7:

Relevant External Links for BCAS1 Gene

GeneLoc Exon Structure for
BCAS1
ECgene alternative splicing isoforms for
BCAS1

Expression for BCAS1 Gene

mRNA expression in normal human tissues for BCAS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCAS1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (16.3), Brain - Substantia nigra (6.5), Brain - Putamen (basal ganglia) (4.7), Brain - Amygdala (4.5), and Brain - Hippocampus (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCAS1 Gene

SOURCE GeneReport for Unigene cluster for BCAS1 Gene Hs.400556

mRNA Expression by UniProt/SwissProt for BCAS1 Gene

O75363-BCAS1_HUMAN
Tissue specificity: Expressed in brain and prostate, and at lower levels in testis, intestine and colon. Overexpressed in most breast cancer cell lines and down-regulated in some colorectal tumors.
genes like me logo Genes that share expressions with BCAS1: view

Orthologs for BCAS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCAS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCAS1 36
  • 99.37 (n)
  • 99.32 (a)
BCAS1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BCAS1 36
  • 80.2 (n)
  • 76.14 (a)
BCAS1 37
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCAS1 36
  • 83.63 (n)
  • 75.7 (a)
BCAS1 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcas1 36
  • 75.51 (n)
  • 64.57 (a)
Bcas1 16
Bcas1 37
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCAS1 37
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCAS1 37
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcas1 36
  • 76.4 (n)
  • 66.15 (a)
chicken
(Gallus gallus)
Aves BCAS1 36
  • 57.65 (n)
  • 43.92 (a)
BCAS1 37
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCAS1 37
  • 32 (a)
OneToOne
Species with no ortholog for BCAS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BCAS1 Gene

ENSEMBL:
Gene Tree for BCAS1 (if available)
TreeFam:
Gene Tree for BCAS1 (if available)

Paralogs for BCAS1 Gene

No data available for Paralogs for BCAS1 Gene

Variants for BCAS1 Gene

Sequence variations from dbSNP and Humsavar for BCAS1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1952 -- 53,944,104(+) AACAA(C/T)GCTTA utr-variant-3-prime
rs11247 -- 53,943,626(-) ATGTA(A/T)TTCAA utr-variant-3-prime, downstream-variant-500B
rs71623 -- 54,044,556(-) CCGGC(C/T)GGAAA intron-variant
rs81484 -- 54,057,749(+) gacat(A/G)catag intron-variant
rs103926 -- 54,067,762(-) CCCCT(C/T)CCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCAS1 Gene

Variant ID Type Subtype PubMed ID
esv34060 CNV Loss 18971310
dgv66n68 CNV Loss 17160897
nsv820262 CNV Loss 19587683
esv25594 CNV Loss 19812545
nsv3419 CNV Loss 18451855
esv2465974 CNV Insertion 19546169
esv268120 CNV Insertion 20981092
esv2663008 CNV Deletion 23128226
nsv437187 CNV Loss 16327808
nsv527711 CNV Loss 19592680
dgv4579n71 CNV Loss 21882294
nsv517164 CNV Gain+Loss 19592680
esv2663949 CNV Deletion 23128226
esv2722548 CNV Deletion 23290073
esv23291 CNV Loss 19812545
nsv514943 CNV Loss 21397061
esv2421391 CNV Deletion 20811451
nsv442485 CNV CNV 18776908
dgv513n27 CNV Loss 19166990
nsv817899 CNV Loss 17921354
nsv433324 CNV Loss 18776910
nsv179659 CNV Loss 16902084
dgv1335e1 CNV Complex 17122850
nsv912944 CNV Loss 21882294

Relevant External Links for BCAS1 Gene

HapMap Linkage Disequilibrium report
BCAS1

Disorders for BCAS1 Gene

(1) MalaCards Diseases for BCAS1 Gene

Search for BCAS1 Gene in MalaCards »

Relevant External Links for BCAS1

Genetic Association Database (GAD)
BCAS1
Human Genome Epidemiology (HuGE) Navigator
BCAS1
genes like me logo Genes that share disorders with BCAS1: view

No data available for UniProtKB/Swiss-Prot for BCAS1 Gene

Publications for BCAS1 Gene

  1. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. (PMID: 9671742) Collins C. … Gray J.W. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  2. Characterization of the novel amplified in breast cancer-1 (NABC1) gene product. (PMID: 14567997) Beardsley D.I. … Brown K.D. (Exp. Cell Res. 2003) 3 4 23
  3. NABC1 (BCAS1): alternative splicing and downregulation in colorectal tumors. (PMID: 10857754) Correa R.G. … de Souza S.J. (Genomics 2000) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for BCAS1 Gene

Sources for BCAS1 Gene

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