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Aliases for BCAR4 Gene

Subcategory (RNA class) for BCAR4 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for BCAR4 Gene

  • Breast Cancer Anti-Estrogen Resistance 4 (Non-Protein Coding) 2 3 5
  • Breast Cancer Anti-Estrogen Resistance 4 2

External Ids for BCAR4 Gene

Previous GeneCards Identifiers for BCAR4 Gene

  • GC16U900561
  • GC16M011913
  • GC16M011830

Summaries for BCAR4 Gene

Entrez Gene Summary for BCAR4 Gene

  • This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2015]

GeneCards Summary for BCAR4 Gene

BCAR4 (Breast Cancer Anti-Estrogen Resistance 4 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with BCAR4 include Estrogen Resistance and Breast Cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAR4 Gene

Genomics for BCAR4 Gene

Regulatory Elements for BCAR4 Gene

Enhancers for BCAR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F011825 0.7 ENCODE 0.8 +3.1 3147 0.2 HMG20B TEAD1 CEBPG TEAD3 ZNF121 ZFHX2 HDAC2 CEBPA ZBTB33 SMAD4 BCAR4 PIR45623
GH16F011822 1.4 Ensembl ENCODE 0.4 +5.1 5071 3.1 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 RSL1D1 COX6CP1 NPIPB2 BCAR4 PIR45623
GH16F011833 1.2 Ensembl ENCODE 0.4 -7.1 -7146 4.2 PKNOX1 ARID4B FEZF1 YY1 FOS KLF7 PAF1 REST TSHZ1 KAT8 GSPT1 NPIPB2 RSL1D1 ENSG00000261560 BCAR4 LOC105371084
GH16F011819 0.9 ENCODE 0.4 +8.9 8867 0.2 HDAC1 PKNOX1 ATF1 FEZF1 ZNF2 CREM EGR2 YY2 NCOA1 ELF1 BCAR4 PIR45623
GH16F011809 1.2 Ensembl ENCODE 0.3 +18.6 18572 1.7 ELF3 TBP MLX ARID4B DMAP1 ZSCAN9 DNMT3B SLC30A9 ZNF121 ZNF143 ZC3H7A LOC105371089 PIR45623 BCAR4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BCAR4 on UCSC Golden Path with GeneCards custom track

Genomic Location for BCAR4 Gene

Chromosome:
16
Start:
11,819,829 bp from pter
End:
11,828,845 bp from pter
Size:
9,017 bases
Orientation:
Minus strand

Genomic View for BCAR4 Gene

Genes around BCAR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCAR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCAR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAR4 Gene

Proteins for BCAR4 Gene

  • Protein details for BCAR4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    D3DUG6
    Recommended name:
    Breast cancer antiestrogen resistance 4 protein
    Protein Accession:
    D3DUG6

    Protein attributes for BCAR4 Gene

    Size:
    121 amino acids
    Molecular mass:
    13174 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BCAR4 Gene

Post-translational modifications for BCAR4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for BCAR4 Gene

Domains & Families for BCAR4 Gene

Protein Domains for BCAR4 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BCAR4: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for BCAR4 Gene

Function for BCAR4 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BCAR4 Gene

Localization for BCAR4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for BCAR4 Gene

Pathways & Interactions for BCAR4 Gene

SuperPathways for BCAR4 Gene

No Data Available

Interacting Proteins for BCAR4 Gene

Gene Ontology (GO) - Biological Process for BCAR4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BCAR4 Gene

Transcripts for BCAR4 Gene

Unigene Clusters for BCAR4 Gene

Breast cancer anti-estrogen resistance 4 (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCAR4 Gene

No ASD Table

Relevant External Links for BCAR4 Gene

GeneLoc Exon Structure for
BCAR4
ECgene alternative splicing isoforms for
BCAR4

Expression for BCAR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BCAR4 Gene

NURSA nuclear receptor signaling pathways regulating expression of BCAR4 Gene:

BCAR4

SOURCE GeneReport for Unigene cluster for BCAR4 Gene:

Hs.24611
genes like me logo Genes that share expression patterns with BCAR4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for BCAR4 Gene

Orthologs for BCAR4 Gene

Evolution for BCAR4 Gene

ENSEMBL:
Gene Tree for BCAR4 (if available)
TreeFam:
Gene Tree for BCAR4 (if available)

No data available for Orthologs for BCAR4 Gene

Paralogs for BCAR4 Gene

No data available for Paralogs for BCAR4 Gene

Variants for BCAR4 Gene

Sequence variations from dbSNP and Humsavar for BCAR4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10744977 -- 11,829,179(+) AGGCG(C/G)GTGGA upstream-variant-2KB
rs10852340 -- 11,823,489(+) cgtgg(C/T)ggcac intron-variant
rs10852341 -- 11,823,592(+) gtact(C/G)cagct intron-variant
rs11075021 -- 11,819,526(+) TTATG(C/T)TTTAG downstream-variant-500B
rs11075022 -- 11,827,406(+) GTTTT(C/T)TCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCAR4 Gene

Variant ID Type Subtype PubMed ID
nsv1120318 CNV tandem duplication 24896259
nsv1043909 CNV gain 25217958
esv3637941 CNV loss 21293372
esv3637940 CNV loss 21293372

Relevant External Links for BCAR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCAR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for BCAR4 Gene

Disorders for BCAR4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BCAR4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
estrogen resistance
  • estrogen insensitivity
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search BCAR4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BCAR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCAR4
genes like me logo Genes that share disorders with BCAR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCAR4 Gene

Publications for BCAR4 Gene

  1. Breast-cancer anti-estrogen resistance 4 (BCAR4) encodes a novel maternal-effect protein in bovine and is expressed in the oocyte of humans and other non-rodent mammals. (PMID: 23202989) Angulo L. … Dalbies-Tran R. (Hum. Reprod. 2013) 2 3 64
  2. Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells. (PMID: 16778085) Meijer D. … Dorssers L.C. (Mol. Cancer Res. 2006) 2 3 64
  3. LncRNA BCAR4 wires up signaling transduction in breast cancer. (PMID: 26016563) Xing Z. … Yang L. (RNA Biol 2015) 3 64
  4. Breast Cancer Anti-Estrogen Resistance 4 (BCAR4) Drives Proliferation of IPH-926 lobular Carcinoma Cells. (PMID: 26317614) van Agthoven T. … Christgen M. (PLoS ONE 2015) 3 64
  5. lncRNA directs cooperative epigenetic regulation downstream of chemokine signals. (PMID: 25416949) Xing Z. … Yang L. (Cell 2014) 3 64

Products for BCAR4 Gene

Sources for BCAR4 Gene

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