breast cancer anti-estrogen resistance 4 (non-protein coding) breast cancer anti-estrogen resistance 4 )
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Aliasesfor BCAR4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Subcategory (RNA class): lncRNAQuality score for this RNA gene is 3 Aliases Breast Cancer Anti-Estrogen Resistance 4 (Non-Protein Coding) 1 2 Breast Cancer Anti-Estrogen Resistance 41 HCG1814062, Isoform CRA_a4
External Ids: HGNC: 22170 1 Entrez Gene: 400500 2 Ensembl: ENSG00000262117 7 OMIM: 613746 5 UniProtKB: D3DUG6 4 ORGUL members: NONCODE:n379755 n406537
Export aliases for BCAR4 gene to outside databases Previous GC identifers: GC16U900561 GC16M011830
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Summariesfor BCAR4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section
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Genomic Viewsfor BCAR4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010393.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the BCAR4 gene promoter:GR ISGF-3 HOXA3 GR-beta CUTL1 GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for BCAR4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCAR4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16p13.13 Ensembl cytogenetic band: 16p13.13 HGNC cytogenetic band: 16p13.13 BCAR4 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16M011913: view genomic region
(about GC identifiers )
Start: 11,913,686 bp from pter End:
11,922,702 bp from pter
Size: 9,017 bases Orientation:
minus strand
ORGUL member locations:Legend (see complete legend)
11913691 11918190 11922689 chr16
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Proteinsfor BCAR4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/TrEMBL: D3DUG6 See
protein sequence )Recommended Name: Size : 121 amino acids; 13174 Da
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Protein
Domains /for BCAR4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: D3DUG6
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Functionfor BCAR4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR4
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Pathways & Interactionsfor BCAR4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BCAR4
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Drugs & Compoundsfor BCAR4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for BCAR4 BCAR4
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Transcriptsfor BCAR4 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section Unigene Cluster for BCAR4:
Breast cancer anti-estrogen resistance 4 (non-protein coding) Hs.24611 [show with all ESTs ] Unigene Representative Sequence: NR_024049 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000571259(lincRNA) ENST00000573037(lincRNA) (uc010uyv.2 ) ENST00000571158(lincRNA) ENST00000573319(lincRNA) ENST00000574028(lincRNA) ENST00000577041(lincRNA) Additional cDNA sequence: HE601934.1 NR_024049.1 NR_024050.1
8 DOTS entries : DT.113598 DT.120680629 DT.113599 DT.91662130 DT.100745614 DT.100772727 DT.91662141 DT.91662143
24/35 AceView cDNA sequences (see all 35 ):
H03972 CR606007 BX107175 BF435983 BF435666 AI089255 N30806 H03167 CR622966 BG622954 AA203647 BG619556 BG572420 BX336046 N32860 R79710 R70627 BG571125 N41814 BG573316 BX338041 R78073 BX338040 N41580 GeneLoc Exon Structure
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Expression for BCAR4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section Expression evidence for BCAR4:none See probesets specificity/sensitivity at GeneAnnot CGAP TAG: -- BCAR4 expression in embryonic tissues and stem cells About this table
1 LifeMap In Vivo Development Anatomical Compartment/CellTissue Category (developmental path) Ovary Antral Follicle Secondary Oocyte Female Gametocytes, Germ Cells Expression: Experimental details:
In-situ hybridization
Genevestigator expression for BCAR4 SOURCE GeneReport for Unigene cluster: Hs.24611 SABiosciences Custom PCR Arrays for BCAR4 Primer Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR4
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Orthologsfor BCAR4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
ENSEMBL Gene Tree for BCAR4 (if available)TreeFam Gene Tree for BCAR4 (if available)
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Paralogsfor BCAR4 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section
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Genomic Variantsfor BCAR4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 16 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for BCAR4 (11913686 - 11922702 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for BCAR4: --
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor BCAR4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 613746
OMIM disorders : --2 : About MalaCards estrogen resistance breast cancer Export disorders for BCAR4 gene to outside databases
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Publicationsfor BCAR4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for BCAR4 gene integrated from 9 sources :(articles sorted by number of sources associating them with BCAR4) Utopia : connect your pdf to the dynamic
Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells. (PubMed id 16778085) 1 , 3(2006) Characterization of BCAR4, a novel oncogene causing e ndocrine resistance in human breast cancer cells. (PubMed id 21506106) 1 (2011) Relevance of BCAR4 in tamoxifen resistance and tumour aggressiveness of human breast cancer. (PubMed id 20859285) 1 (2010)
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External Searches for BCAR4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing BCAR4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing BCAR4 gene
(According to HUGE )
About This Section --
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Specialized Databases showing BCAR4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for BCAR4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for BCAR4 gene: BCAR4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor BCAR4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BCAR4 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCAR4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCAR4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for BCAR4
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR4
Search ThermoFisher Antibodies for BCAR4
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BCAR4
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