Subcategory (RNA class) for BCAR4 Gene
Quality Score for this RNA gene is
Aliases for BCAR4 Gene
Previous GeneCards Identifiers for BCAR4 Gene
This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2015]
GeneCards Summary for BCAR4 Gene
BCAR4 (Breast Cancer Anti-Estrogen Resistance 4 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with BCAR4 include estrogen resistance and breast cancer.