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Aliases for BCAR4 Gene

Subcategory (RNA class) for BCAR4 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for BCAR4 Gene

  • Breast Cancer Anti-Estrogen Resistance 4 (Non-Protein Coding) 2 3
  • Breast Cancer Anti-Estrogen Resistance 4 2

External Ids for BCAR4 Gene

Previous GeneCards Identifiers for BCAR4 Gene

  • GC16U900561
  • GC16M011913
  • GC16M011830

Summaries for BCAR4 Gene

Entrez Gene Summary for BCAR4 Gene

  • This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2015]

GeneCards Summary for BCAR4 Gene

BCAR4 (Breast Cancer Anti-Estrogen Resistance 4 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with BCAR4 include estrogen resistance and breast cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAR4 Gene

Genomics for BCAR4 Gene

Regulatory Elements for BCAR4 Gene

Genomic Location for BCAR4 Gene

Chromosome:
16
Start:
11,819,829 bp from pter
End:
11,828,845 bp from pter
Size:
9,017 bases
Orientation:
Minus strand

Genomic View for BCAR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCAR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAR4 Gene

Proteins for BCAR4 Gene

  • Protein details for BCAR4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    D3DUG6
    Recommended name:
    Breast cancer antiestrogen resistance 4 protein
    Protein Accession:
    D3DUG6

    Protein attributes for BCAR4 Gene

    Size:
    121 amino acids
    Molecular mass:
    13174 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BCAR4 Gene

Proteomics data for BCAR4 Gene at MOPED

Post-translational modifications for BCAR4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for BCAR4 Gene

Domains & Families for BCAR4 Gene

Protein Domains for BCAR4 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BCAR4: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for BCAR4 Gene

Function for BCAR4 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BCAR4 Gene

Localization for BCAR4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for BCAR4 Gene

Pathways & Interactions for BCAR4 Gene

SuperPathways for BCAR4 Gene

No Data Available

Interacting Proteins for BCAR4 Gene

Gene Ontology (GO) - Biological Process for BCAR4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BCAR4 Gene

Drugs & Compounds for BCAR4 Gene

No Compound Related Data Available

Transcripts for BCAR4 Gene

Unigene Clusters for BCAR4 Gene

Breast cancer anti-estrogen resistance 4 (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCAR4 Gene

No ASD Table

Relevant External Links for BCAR4 Gene

GeneLoc Exon Structure for
BCAR4
ECgene alternative splicing isoforms for
BCAR4

Expression for BCAR4 Gene

mRNA expression in normal human tissues for BCAR4 Gene

SOURCE GeneReport for Unigene cluster for BCAR4 Gene Hs.24611

genes like me logo Genes that share expression patterns with BCAR4: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BCAR4 Gene

Orthologs for BCAR4 Gene

Evolution for BCAR4 Gene

ENSEMBL:
Gene Tree for BCAR4 (if available)
TreeFam:
Gene Tree for BCAR4 (if available)

No data available for Orthologs for BCAR4 Gene

Paralogs for BCAR4 Gene

No data available for Paralogs for BCAR4 Gene

Variants for BCAR4 Gene

Sequence variations from dbSNP and Humsavar for BCAR4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs718080 -- 11,828,657(-) TTATT(A/T)TTTTT nc-transcript-variant, intron-variant
rs718081 -- 11,828,206(-) TATAT(C/T)TTTTT intron-variant
rs846152 -- 11,827,651(-) ttctc(A/C)tgcct intron-variant
rs860134 -- 11,827,680(-) tgcaa(C/G)ctccg intron-variant
rs860135 -- 11,827,669(-) cctcc(C/T)gggtt intron-variant

Relevant External Links for BCAR4 Gene

HapMap Linkage Disequilibrium report
BCAR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for BCAR4 Gene

Disorders for BCAR4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BCAR4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
estrogen resistance
  • estrogen insensitivity
breast cancer
  • breast cancer, invasive ductal
- elite association
Search BCAR4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BCAR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCAR4
genes like me logo Genes that share disorders with BCAR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCAR4 Gene

Publications for BCAR4 Gene

  1. Breast-cancer anti-estrogen resistance 4 (BCAR4) encodes a novel maternal-effect protein in bovine and is expressed in the oocyte of humans and other non-rodent mammals. (PMID: 23202989) Angulo L. … Dalbies-Tran R. (Hum. Reprod. 2013) 2 67
  2. Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells. (PMID: 16778085) Meijer D. … Dorssers L.C. (Mol. Cancer Res. 2006) 2 67
  3. LncRNA BCAR4 wires up signaling transduction in breast cancer. (PMID: 26016563) Xing Z. … Yang L. (RNA Biol 2015) 67
  4. lncRNA directs cooperative epigenetic regulation downstream of chemokine signals. (PMID: 25416949) Xing Z. … Yang L. (Cell 2014) 67
  5. Protein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell lines. (PMID: 22328489) van Agthoven T. … Dorssers L.C. (Int. J. Cancer 2012) 67

Products for BCAR4 Gene

Sources for BCAR4 Gene

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