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Aliases for BCAR3 Gene

Aliases for BCAR3 Gene

  • Breast Cancer Anti-Estrogen Resistance 3 2 3 5
  • SH2 Domain-Containing Protein 3B 3 4
  • Novel SH2-Containing Protein 2 3 4
  • SH2D3B 3 4
  • NSP2 3 4
  • DJ1033H22.2 (Breast Cancer Anti-Estrogen Resistance 3) 3
  • Breast Cancer Anti-Estrogen Resistance Protein 3 3
  • Breast Cancer Antiestrogen Resistance 3 Protein 3

External Ids for BCAR3 Gene

Previous GeneCards Identifiers for BCAR3 Gene

  • GC01M094433
  • GC01M093233
  • GC01M093377
  • GC01M093499
  • GC01M093739
  • GC01M093799
  • GC01M094027
  • GC01M092148

Summaries for BCAR3 Gene

Entrez Gene Summary for BCAR3 Gene

  • Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for BCAR3 Gene

BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) is a Protein Coding gene. Diseases associated with BCAR3 include Estrogen Resistance and Breast Cancer. Among its related pathways are Regulation of CDC42 activity and Tyrosine Kinases / Adaptors. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is SH2D3C.

UniProtKB/Swiss-Prot for BCAR3 Gene

  • May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.

Gene Wiki entry for BCAR3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAR3 Gene

Genomics for BCAR3 Gene

Regulatory Elements for BCAR3 Gene

Enhancers for BCAR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G093773 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +69.0 69045 9.5 FOXA2 ARID4B SIN3A DMAP1 FEZF1 ZNF416 FOS ZNF263 SP3 SP5 ENSG00000230439 TRR-TCT1-1 BCAR3 LOC100129046 GCLM ARHGAP29 FNBP1L GC01M093783
GH01G093565 1.3 ENCODE dbSUPER 22.4 +280.2 280224 3.0 HDGF PKNOX1 CREB3L1 ARNT SIN3A ARID4B ZNF766 CBX5 FOS SP5 BCAR3 LOC100129046 CCDC18-AS1 DR1 SNORD21 SNORA66 GC01M093557
GH01G093621 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.7 +222.9 222876 5.8 PKNOX1 SAP130 JUN ZNF140 SIN3A CEBPG FEZF1 BMI1 RAD21 RARA BCAR3 MIR760 LOC100129046 GCLM DR1 GC01M093613 GC01M093588
GH01G093612 1.6 Ensembl ENCODE dbSUPER 17.7 +230.8 230844 8.3 FOXA2 MLX ZFP64 ARID4B DMAP1 FEZF1 YY1 FOS SP5 ZHX2 BCAR3 LOC100129046 MIR760 GCLM CCDC18-AS1 GC01M093588 GC01M093613
GH01G093749 1.5 Ensembl ENCODE dbSUPER 15.2 +93.8 93795 7.9 PKNOX1 FOXA2 ATF1 BRCA1 YY1 GATA2 FOS PPARG TBX21 KAT8 ENSG00000230439 BCAR3 MIR760 GCLM TRR-TCT1-1 GC01P093728
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BCAR3 on UCSC Golden Path with GeneCards custom track

Promoters for BCAR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000010020 -150 2600 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZNF610 GLIS1 RCOR2

Genomic Location for BCAR3 Gene

Chromosome:
1
Start:
93,561,786 bp from pter
End:
93,847,150 bp from pter
Size:
285,365 bases
Orientation:
Minus strand

Genomic View for BCAR3 Gene

Genes around BCAR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCAR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCAR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAR3 Gene

Proteins for BCAR3 Gene

  • Protein details for BCAR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75815-BCAR3_HUMAN
    Recommended name:
    Breast cancer anti-estrogen resistance protein 3
    Protein Accession:
    O75815
    Secondary Accessions:
    • D3DT43
    • Q5TEW3
    • Q6UW40
    • Q9BR50

    Protein attributes for BCAR3 Gene

    Size:
    825 amino acids
    Molecular mass:
    92566 Da
    Quaternary structure:
    • Interacts with BCAR1, NEDD9, PTK2/FAK1 and PTPN1.

    Three dimensional structures from OCA and Proteopedia for BCAR3 Gene

    Alternative splice isoforms for BCAR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCAR3 Gene

Post-translational modifications for BCAR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BCAR3 (BCAR3)
  • Cloud-Clone Corp. Antibodies for BCAR3
  • Santa Cruz Biotechnology (SCBT) Antibodies for BCAR3

No data available for DME Specific Peptides for BCAR3 Gene

Domains & Families for BCAR3 Gene

Gene Families for BCAR3 Gene

Suggested Antigen Peptide Sequences for BCAR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BCAR3: view

No data available for UniProtKB/Swiss-Prot for BCAR3 Gene

Function for BCAR3 Gene

Molecular function for BCAR3 Gene

UniProtKB/Swiss-Prot Function:
May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.

Gene Ontology (GO) - Molecular Function for BCAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IBA --
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 16273093
genes like me logo Genes that share ontologies with BCAR3: view
genes like me logo Genes that share phenotypes with BCAR3: view

Animal Models for BCAR3 Gene

MGI Knock Outs for BCAR3:

Animal Model Products

CRISPR Products

miRNA for BCAR3 Gene

miRTarBase miRNAs that target BCAR3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCAR3 Gene

Localization for BCAR3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCAR3 gene
Compartment Confidence
cytosol 4
plasma membrane 2
cytoskeleton 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BCAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with BCAR3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BCAR3 Gene

Pathways & Interactions for BCAR3 Gene

genes like me logo Genes that share pathways with BCAR3: view

Pathways by source for BCAR3 Gene

1 Cell Signaling Technology pathway for BCAR3 Gene
1 BioSystems pathway for BCAR3 Gene

Gene Ontology (GO) - Biological Process for BCAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002089 lens morphogenesis in camera-type eye IEA --
GO:0007165 signal transduction TAS 9582273
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0033138 positive regulation of peptidyl-serine phosphorylation IEA --
genes like me logo Genes that share ontologies with BCAR3: view

No data available for SIGNOR curated interactions for BCAR3 Gene

Drugs & Compounds for BCAR3 Gene

(1) Drugs for BCAR3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with BCAR3: view

Transcripts for BCAR3 Gene

Unigene Clusters for BCAR3 Gene

Breast cancer anti-estrogen resistance 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCAR3 Gene

No ASD Table

Relevant External Links for BCAR3 Gene

GeneLoc Exon Structure for
BCAR3
ECgene alternative splicing isoforms for
BCAR3

Expression for BCAR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCAR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BCAR3 Gene

This gene is overexpressed in Placenta (42.6) and Testis (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCAR3 Gene



Protein tissue co-expression partners for BCAR3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BCAR3 Gene:

BCAR3

SOURCE GeneReport for Unigene cluster for BCAR3 Gene:

Hs.36958

mRNA Expression by UniProt/SwissProt for BCAR3 Gene:

O75815-BCAR3_HUMAN
Tissue specificity: Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue.

Evidence on tissue expression from TISSUES for BCAR3 Gene

  • Heart(4.2)
  • Kidney(4.2)
  • Liver(4.2)
  • Lung(4.2)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with BCAR3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCAR3 Gene

Orthologs for BCAR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BCAR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCAR3 34 35
  • 99.31 (n)
cow
(Bos Taurus)
Mammalia BCAR3 34 35
  • 86.99 (n)
dog
(Canis familiaris)
Mammalia BCAR3 34 35
  • 86.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
-- 35
  • 22 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Bcar3 34
  • 84.93 (n)
mouse
(Mus musculus)
Mammalia Bcar3 34 16 35
  • 84.57 (n)
oppossum
(Monodelphis domestica)
Mammalia BCAR3 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves BCAR3 34 35
  • 68.67 (n)
lizard
(Anolis carolinensis)
Reptilia BCAR3 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcar3 34
  • 64.85 (n)
zebrafish
(Danio rerio)
Actinopterygii bcar3 34 35
  • 61.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9098 36 35
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10354 35
  • 32 (a)
OneToMany
Species where no ortholog for BCAR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCAR3 Gene

ENSEMBL:
Gene Tree for BCAR3 (if available)
TreeFam:
Gene Tree for BCAR3 (if available)

Paralogs for BCAR3 Gene

Paralogs for BCAR3 Gene

(2) SIMAP similar genes for BCAR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BCAR3: view

Variants for BCAR3 Gene

Sequence variations from dbSNP and Humsavar for BCAR3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000001650 -- 93,796,809(+) GGGAC(-/AG)AACAA intron-variant
rs1000014221 -- 93,748,190(+) AGAGA(C/G)ATAGC intron-variant
rs1000014862 -- 93,705,219(+) ATGTA(A/G)GCATC intron-variant
rs1000043970 -- 93,741,049(+) TGCTC(A/G)GCTGA intron-variant
rs1000044965 -- 93,690,855(+) CTAGG(C/G)CATTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BCAR3 Gene

Variant ID Type Subtype PubMed ID
dgv127n106 CNV deletion 24896259
dgv368n54 CNV gain+loss 21841781
dgv369n54 CNV loss 21841781
dgv370n54 CNV loss 21841781
dgv371n54 CNV loss 21841781
dgv372n54 CNV gain 21841781
dgv373n54 CNV loss 21841781
dgv374n54 CNV loss 21841781
dgv4e180 CNV loss 20482838
dgv56n67 CNV loss 20364138
esv1003322 CNV deletion 20482838
esv1005153 CNV deletion 20482838
esv1011314 CNV deletion 20482838
esv1112742 CNV deletion 17803354
esv2062392 CNV deletion 18987734
esv2442893 CNV deletion 19546169
esv2595696 CNV deletion 19546169
esv2657590 CNV deletion 23128226
esv2660297 CNV deletion 23128226
esv2676089 CNV deletion 23128226
esv2714884 CNV deletion 23290073
esv2714895 CNV deletion 23290073
esv27447 CNV gain+loss 19812545
esv27510 CNV loss 19812545
esv2850902 CNV deletion 24192839
esv33428 CNV loss 17666407
esv33739 CNV gain+loss 17666407
esv3565915 CNV deletion 23714750
esv3565926 CNV deletion 23714750
esv3586831 CNV loss 21293372
esv3586832 CNV loss 21293372
esv3586833 CNV loss 21293372
esv5334 CNV loss 18987735
esv8088 CNV loss 19470904
esv8503 CNV gain 19470904
nsv1011853 CNV loss 25217958
nsv1133879 CNV deletion 24896259
nsv1146358 CNV deletion 26484159
nsv160444 CNV deletion 16902084
nsv1877 CNV deletion 18451855
nsv508415 CNV deletion 20534489
nsv546822 CNV gain 21841781
nsv546829 CNV gain+loss 21841781
nsv546830 CNV loss 21841781
nsv821520 CNV deletion 20802225
nsv955753 CNV deletion 24416366
nsv998755 CNV loss 25217958

Variation tolerance for BCAR3 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 67.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCAR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCAR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCAR3 Gene

Disorders for BCAR3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BCAR3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
estrogen resistance
  • estrogen insensitivity
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search BCAR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BCAR3

Genetic Association Database (GAD)
BCAR3
Human Genome Epidemiology (HuGE) Navigator
BCAR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCAR3
genes like me logo Genes that share disorders with BCAR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCAR3 Gene

Publications for BCAR3 Gene

  1. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. (PMID: 9582273) van Agthoven T. … Dorssers L.C.J. (EMBO J. 1998) 2 3 4 22 64
  2. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway. (PMID: 10187783) Lu Y. … Stewart T.A. (J. Biol. Chem. 1999) 3 4 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. BCAR3 regulates EGF-induced DNA synthesis in normal human breast MCF-12A cells. (PMID: 18722344) Oh M.J. … Jhun B.H. (Biochem. Biophys. Res. Commun. 2008) 3 22 64
  5. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. (PMID: 17427198) Near R.I. … Lerner A. (J. Cell. Physiol. 2007) 3 22 64

Products for BCAR3 Gene

Sources for BCAR3 Gene

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