Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BCAR3 Gene

protein-coding   GIFtS: 56
GCID: GC01M094027

Breast Cancer Anti-Estrogen Resistance 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Breast Cancer Anti-Estrogen Resistance 31 2     SH2 Domain-Containing Protein 3B2 3
Novel SH2-Containing Protein 22 3     Breast Cancer Anti-Estrogen Resistance Protein 32
NSP22 3     Breast Cancer Antiestrogen Resistance 3 Protein2
SH2D3B2 3     DJ1033H22.2 (Breast Cancer Anti-Estrogen Resistance 3)2

External Ids:    HGNC: 9731   Entrez Gene: 84122   Ensembl: ENSG000001379367   OMIM: 6047045   UniProtKB: O758153   

Export aliases for BCAR3 gene to outside databases

Previous GC identifers: GC01M094433 GC01M093233 GC01M093377 GC01M093499 GC01M093739 GC01M093799 GC01M092148


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for BCAR3 Gene:
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by
anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast
cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of
estrogen resistance. The gene encodes a component of intracellular signal transduction that causes
estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2
(SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell
division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, May 2012)

GeneCards Summary for BCAR3 Gene:
BCAR3 (breast cancer anti-estrogen resistance 3) is a protein-coding gene. Diseases associated with BCAR3 include estrogen resistance, and venezuelan equine encephalitis. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is SH2D3C.

UniProtKB/Swiss-Prot: BCAR3_HUMAN, O75815
Function: May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that
regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in
breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins

Gene Wiki entry for BCAR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the BCAR3 gene promoter:
         STAT5A   HNF-3beta   CBF-C   AREB6   Ik-2   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): BCAR3 promoter sequence
   Search Chromatin IP Primers for BCAR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCAR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1   Ensembl cytogenetic band:  1p22.1   HGNC cytogenetic band: 1p22.1

BCAR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCAR3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M094027:  view genomic region     (about GC identifiers)

Start:
94,027,347 bp from pter      End:
94,312,706 bp from pter
Size:
285,360 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BCAR3_HUMAN, O75815 (See protein sequence)
Recommended Name: Breast cancer anti-estrogen resistance protein 3  
Size: 825 amino acids; 92566 Da
Subunit: Interacts with BCAR1, NEDD9, PTK2/FAK1 and PTPN1 (By similarity)
1 PDB 3D structure from and Proteopedia for BCAR3:
3T6A (3D)    
Secondary accessions: D3DT43 Q5TEW3 Q6UW40 Q9BR50
Alternative splicing: 3 isoforms:  O75815-1   O75815-2   O75815-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BCAR3: NX_O75815

Explore proteomics data for BCAR3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BCAR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001248337.1  NP_001248338.1  NP_001248339.1  NP_003558.1  

    ENSEMBL proteins: 
     ENSP00000359267   ENSP00000260502   ENSP00000359264   ENSP00000359263   ENSP00000441343  

    BCAR3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BCAR3
    OriGene Protein Over-expression Lysate for BCAR3
    OriGene MassSpec for BCAR3
    OriGene Custom Protein Services for BCAR3
    GenScript Custom Purified and Recombinant Proteins Services for BCAR3
    Novus Biologicals BCAR3 Protein
    Novus Biologicals BCAR3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BCAR3

    BCAR3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BCAR3
    Browse R&D Systems for Antibodies
    OriGene Antibodies for BCAR3
    OriGene Custom Antibody Services for BCAR3
    Novus Biologicals BCAR3 Antibodies
    Abcam antibodies for BCAR3
    Cloud-Clone Corp. Antibodies for BCAR3
    ThermoFisher Antibodies for BCAR3
    LSBio Antibodies in human, mouse, rat for BCAR3

    BCAR3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BCAR3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BCAR3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BCAR3
    Cloud-Clone Corp. CLIAs for BCAR3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SH2D: SH2 domain containing

    4 InterPro protein domains:
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25
     IPR000980 SH2
     IPR028849 BCAR3

    Graphical View of Domain Structure for InterPro Entry O75815

    ProtoNet protein and cluster: O75815

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: BCAR3_HUMAN, O75815
    Similarity: Contains 1 Ras-GEF domain
    Similarity: Contains 1 SH2 domain


    BCAR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCAR3_HUMAN, O75815
    Function: May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that
    regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in
    breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding IPI16273093
         
    BCAR3 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bcar3):
     nervous system  vision/eye 

    BCAR3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bcar3tm1Lern for BCAR3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCAR3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCAR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCAR3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCAR3

    miRNA
    Products:
        
    miRTarBase miRNAs that target BCAR3:
    hsa-mir-196b-5p (MIRT042690)

    Block miRNA regulation of human, mouse, rat BCAR3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BCAR3 (see all 15):
    hsa-miR-595 hsa-miR-222* hsa-miR-1237 hsa-miR-199b-3p hsa-miR-186* hsa-miR-199a-3p hsa-miR-487a hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmidBCAR3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BCAR3
    Predesigned siRNA for gene silencing in human, mouse, rat BCAR3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BCAR3

    Clone
    Products:
         
    OriGene clones in human, mouse for BCAR3 (see all 8)
    OriGene ORF clones in mouse, rat for BCAR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BCAR3 (NM_003567)
    Sino Biological Human cDNA Clone for BCAR3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAR3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BCAR3
    Browse ESI BIO Cell Lines and PureStem Progenitors for BCAR3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    BCAR3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for BCAR3 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of CDC42 activity
    Regulation of CDC42 activity


    1 BioSystems Pathway for BCAR3
        Regulation of CDC42 activity



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BCAR3
    Interactions:

        GeneGlobe Interaction Network for BCAR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BCAR3 (O758151, 3 ENSP000002605024) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 3, ENSP000002695714EBI-702336,EBI-641062 I2D: score=1 STRING: ENSP00000269571
    NEDD9Q145113, ENSP000003687594I2D: score=3 STRING: ENSP00000368759
    BCAR1P569453, ENSP000001623304I2D: score=2 STRING: ENSP00000162330
    IMPDH2P122683, ENSP000003215844I2D: score=2 STRING: ENSP00000321584
    PABPC1P119403, ENSP000003130074I2D: score=2 STRING: ENSP00000313007
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9582273
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0042493response to drug TAS9582273

    BCAR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BCAR3

    1 Novoseek inferred chemical compound relationship for BCAR3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 14.7 3 18351453 (1), 19075277 (1)



    BCAR3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BCAR3 gene (4 alternative transcripts): 
    NM_001261408.1  NM_001261409.1  NM_001261410.1  NM_003567.3  

    Unigene Cluster for BCAR3:

    Breast cancer anti-estrogen resistance 3
    Hs.36958  [show with all ESTs]
    Unigene Representative Sequence: BC028477
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370247(uc001dpy.3) ENST00000260502(uc001dqa.3) ENST00000370244(uc001dqb.3)
    ENST00000370243(uc001dpz.3) ENST00000538653 ENST00000466632 ENST00000490377
    ENST00000479503 ENST00000469315 ENST00000539242(uc001dpx.4 uc009wdm.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BCAR3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BCAR3 (see all 15):
    hsa-miR-595 hsa-miR-222* hsa-miR-1237 hsa-miR-199b-3p hsa-miR-186* hsa-miR-199a-3p hsa-miR-487a hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmidBCAR3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BCAR3
    Predesigned siRNA for gene silencing in human, mouse, rat BCAR3
    Clone
    Products:
         
    OriGene clones in human, mouse for BCAR3 (see all 8)
    OriGene ORF clones in mouse, rat for BCAR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BCAR3 (NM_003567)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAR3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BCAR3
    OriGene qSTAR qPCR primer pairs in human, mouse for BCAR3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCAR3
      QuantiTect SYBR Green Assays in human, mouse, rat BCAR3
      QuantiFast Probe-based Assays in human, mouse, rat BCAR3

    Additional mRNA sequence: 

    AF124250.1 AK027785.1 AK055442.1 AK301570.1 AK310970.1 AL833121.1 AY358996.1 BC028477.1 
    BC039895.1 U92715.1 

    11 DOTS entries:

    DT.75191686  DT.95248561  DT.99980444  DT.100784061  DT.92426182  DT.95116328  DT.121341346  DT.121341372 
    DT.91670568  DT.99949696  DT.92426183 

    Selected AceView cDNA sequences (see all 165):

    CB132451 AF124250 CB306590 AI627302 BQ014234 CA454914 BF940335 CA442336 
    AK055442 BG110039 BE043094 BQ217872 BC039895 CA502791 CA446369 CB120196 
    BQ028469 BQ889001 BI253306 AI613118 CA306476 BM463861 AY358996 BU628766 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BCAR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGAAAATA
    BCAR3 Expression
    About this image


    BCAR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Adipose (Muscoskeletal System)
             Visceral White Adipocytes Visceral White Adipose
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone
     
     Fibroblasts (Uncategorized)
    BCAR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCAR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.36958

    UniProtKB/Swiss-Prot: BCAR3_HUMAN, O75815
    Tissue specificity: Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast
    tissue

        Custom PCR Arrays for BCAR3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BCAR3
    OriGene qSTAR qPCR primer pairs in human, mouse for BCAR3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCAR3
    QuantiTect SYBR Green Assays in human, mouse, rat BCAR3
    QuantiFast Probe-based Assays in human, mouse, rat BCAR3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for BCAR3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcar31 , 5 breast cancer anti-estrogen resistance 31, 5 84.57(n)1
    86.08(a)1
      3 (53.41 cM)5
    298151  NM_013867.21  NP_038895.11 
     1224197805 
    chicken
    (Gallus gallus)
    Aves BCAR31 breast cancer anti-estrogen resistance 3 68.67(n)
    69.28(a)
      424494  XM_422334.4  XP_422334.3 
    lizard
    (Anolis carolinensis)
    Reptilia BCAR36
    breast cancer anti-estrogen resistance 3
    63(a)
    1 ↔ 1
    4(88400579-88558171)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX739959.12   -- 74.34(n)    BX739959.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bcar31 breast cancer anti-estrogen resistance 3 61.9(n)
    60.42(a)
      570610  NM_001113620.1  NP_001107092.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90983 SH3/SH2 adaptor protein 34(a)   26B3   --


    ENSEMBL Gene Tree for BCAR3 (if available)
    TreeFam Gene Tree for BCAR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for BCAR3 gene
    SH2D3C2  SH2D3A2  
    2 SIMAP similar genes for BCAR3 using alignment to 1 protein entry:     BCAR3_HUMAN:
    SH2D3C    SH2D3A

    BCAR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BCAR3 (see all 5246)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs741016671,2
    C,F--92270395(+) CACTTT/AAAAAA 1 -- us2k12Minor allele frequency- A:0.07WA 120
    rs1920498171,2
    --92270425(+) AAAAGC/TTAAAT 1 -- us2k10--------
    rs1449007821,2
    --92270484(+) ACAGAG/TATGTA 1 -- us2k10--------
    rs171100631,2
    C,F,H--94026861(+) TCCAAA/GTTTTG 4 -- ds500118Minor allele frequency- G:0.13NA NS EA WA 2106
    rs1439123421,2
    --94026946(+) AACCTA/GGAAAG 4 -- ds50010--------
    rs1885025411,2
    --94027187(+) ACTCTG/TCCTTT 4 -- ds50010--------
    rs617840711,2
    C,F--94027203(+) CAGGAG/ACATTA 4 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1402488651,2
    --94027208(+) ACATTA/GAATTT 4 -- ds50010--------
    rs1502928701,2
    --94027227(+) ACTTTA/CATTCA 4 -- ds50010--------
    rs1918728511,2
    --94027263(+) ACCTAA/GGGAAG 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for BCAR3 (94027347 - 94277347 bp, first 250kb of BCAR3)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BCAR3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BCAR3
    DNA2.0 Custom Variant and Variant Library Synthesis for BCAR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604704    OMIM disorders: --

    5 diseases for BCAR3:    
    About MalaCards
    estrogen resistance    venezuelan equine encephalitis    chikungunya    breast cancer
    encephalitis


    BCAR3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for BCAR3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 45.4 8 17427198 (2), 14583477 (2), 18722344 (2), 18351453 (1) (see all 5)
    tumors 0 1 19075277 (1)

    Genetic Association Database (GAD): BCAR3
    Human Genome Epidemiology (HuGE) Navigator: BCAR3 (3 documents)

    Export disorders for BCAR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BCAR3 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with BCAR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. (PubMed id 9582273)1, 2, 3, 9 van Agthoven T.... Dorssers L.C.J. (EMBO J. 1998)
    2. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway. (PubMed id 10187783)1, 2, 9 Lu Y.... Stewart T.A. (J. Biol. Chem. 1999)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. BCAR3 regulates EGF-induced DNA synthesis in normal human breast MCF-12A cells. (PubMed id 18722344)1, 9 Oh M.J....Jhun B.H. (Biochem. Biophys. Res. Commun. 2008)
    9. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. (PubMed id 17427198)1, 9 Near R.I....Lerner A. (J. Cell. Physiol. 2007)
    10. Breast cancer antiestrogen resistance 3 (BCAR3) promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells. (PubMed id 23762409)1 Wilson A.L....Bouton A.H. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8412 HGNC: 973 AceView: BCAR3 Ensembl:ENSG00000137936 euGenes: HUgn8412
    ECgene: BCAR3 H-InvDB: BCAR3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BCAR3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCAR3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BCAR3 gene:
    Search GeneIP for patents involving BCAR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of BCAR3
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for BCAR3   OriGene RNAi products in human, mouse, rat for BCAR3  
     OriGene qPCR primer pairs and template standards for BCAR3   OriGene Protein Over-expression Lysate for BCAR3  
     OriGene MassSpec something-or-other for BCAR3   OriGene clones in human, mouse for BCAR3  
     OriGene qSTAR qPCR primer pairs in human, mouse for BCAR3   OriGene Purified Protein for BCAR3  
     OriGene ORF clones in mouse, rat for BCAR3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BCAR3   OriGene Custom Protein Services for BCAR3  

     
     
     Block miRNA regulation of human, mouse, rat BCAR3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BCAR3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCAR3 Predesigned siRNA for gene silencing in human, mouse, rat BCAR3
     QuantiFast Probe-based Assays in human, mouse, rat BCAR3 QuantiTect SYBR Green Assays in human, mouse, rat BCAR3
     Custom PCR Arrays for BCAR3 Search Chromatin IP Primers for BCAR3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCAR3  GeneGlobe Interaction Network for BCAR3
     Regulatory tfbs in BCAR3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for BCAR3 GenScript cDNA clones with any tag delivered in your preferred vector for BCAR3
     GenScript Custom Assay Services for BCAR3 GenScript Custom overexpressing Cell Line Services for BCAR3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for BCAR3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for BCAR3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BCAR3 antibodies
     BCAR3 proteins
     BCAR3 lysates
     Antibodies for BCAR3
     See all of Abcam's Antibodies, Kits and Proteins for BCAR3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for BCAR3
     Antibodies for BCAR3
     ELISAs for BCAR3
     CLIAs for BCAR3



     Browse ESI BIO Cell Lines and PureStem Progenitors for BCAR3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR3
     SwitchGear 3'UTR luciferase reporter plasmids for BCAR3
     SwitchGear Promoter luciferase reporter plasmids for BCAR3
     ThermoFisher Antibodies for BCAR3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAR3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCAR3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCAR3
     LSBio Antibodies in human, mouse, rat for BCAR3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BCAR3 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4