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Aliases & Descriptions for BCAR3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KIAA0554 2 | | NSP2 1, 2, 3 | | OTTHUMP00000011959 2 | | OTTHUMP00000011960 2 | | OTTHUMP00000011961 2 | | SH2D3B 1, 2, 3 |
| | | Descriptions |
|---|
| Novel SH2-containing protein 2 3 | | SH2 domain-containing protein 3B 3 | | breast cancer anti-estrogen resistance 3 2 | | breast cancer antiestrogen resistance 3 2 | | dJ1033H22.2 (breast cancer anti-estrogen resistance 3) 2 |
|
| | Search outside databases for aliases for BCAR3 genePrevious GC identifers: GC01M094433 GC01M093233 GC01M093377 GC01M093499 |
Summaries for BCAR3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for BCAR3: Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. [provided by RefSeq] UniProtKB/Swiss-Prot: BCAR3_HUMAN, O75815Function: May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteinsGene Wiki entry for BCAR3 |
Genomic Location for BCAR3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the BCAR3 gene 
Entrez Gene cytogenetic band: 1p22.1 Ensembl cytogenetic band: 1p22.1 HGNC cytogenetic band: 1p22.1BCAR3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M093739:
(about GC identifiers)
Start:
|
93,799,936 bp from pter |
End:
|
94,085,294 bp from pter |
Size:
|
285,359 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_032977.8
| Proteins for BCAR3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: BCAR3_HUMAN, O75815 (See
protein sequence)Recommended Name: Breast cancer anti-estrogen resistance protein 3 Size: 825 amino acids; 92566 Da
Subunit: Interacts with BCAR1, NEDD9, PTK2 and PTPN1 (By similarity)
Secondary accessions: Q6UW40 Q9BR50Alternative splicing: 2 isoforms: O75815-1 O75815-2 Post-translational modifications:
Phosphorylated on tyrosine (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003558.1
ENSEMBL proteins: ENSP00000260502 ENSP00000359264 ENSP00000359263 ENSP00000359267
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- | About this table
Antibodies for BCAR3: Assays for BCAR3: | Protein
Domains/ Families for BCAR3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O75815
ProtoNet protein and cluster: O75815 2 Blocks protein families: IPB000980 SH2 domain signature IPB001895 Guanine-nucleotide dissociation stimulator CDC25
UniProtKB/Swiss-Prot: BCAR3_HUMAN, O75815Similarity: Contains 1 Ras-GEF domainSimilarity: Contains 1 SH2 domain | Gene Function for BCAR3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003567
Applied Biosystems Silencer® siRNAs for BCAR3
Sigma-Aldrich siRNA for BCAR3  Sigma-Aldrich shRNA for BCAR3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003567                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003567                                  untagged cDNA clones in CMV expression vector (see all 2): NM_003567 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003567
UniProtKB/Swiss-Prot: BCAR3_HUMAN, O75815Function: May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for BCAR3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for BCAR3 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for BCAR3 
5/18 Interacting proteins for BCAR3 (O758151 ENSP000002605023) via UniProtKB, MINT, and/or STRING (see all 18
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for BCAR3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for BCAR3
|
Transcripts for BCAR3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003567
Sigma-Aldrich siRNA for BCAR3  Sigma-Aldrich shRNA for BCAR3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003567 REFSEQ mRNAs for BCAR3 gene: NM_003567.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003567               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003567                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003567                                  untagged cDNA clones in CMV expression vector (see all 2): NM_003567  Additional cDNA sequence: AF124250.1 AK027785.1 AK055442.1 AK301570.1 AK310970.1 AL833121.1 AY358996.1 BC028477.1 BC039895.1 CR601884.1 U92715.1 16 DOTS entries: DT.75191686 DT.95248561 DT.99980444 DT.100784061 DT.92426182 DT.95116328 DT.97834718 DT.100667994 DT.121341346 DT.97824276 DT.121341372 DT.91670568 DT.95087753 DT.99949696 DT.91751875 DT.92426183 24/165 AceView cDNA sequences (see all 165
):AI613118 BQ015705 BU618526 BU628766 AK055442 BI824100 BQ889001 BM463861 BU609135 CB306590 AA112335 CB120196 BQ028469 BM849452 F01917 CB961995 BG110039 AF124250 BC039895 AI627302 CA502791 AI199821 CA442336 CA306476
highest scoring ESTs for BCAR3:U92715 AF124250 BC028477 BC039895 BG772336 BI553045 BQ217872 BQ897882 CB961995 AA099941 Unigene Cluster for BCAR3: Breast cancer anti-estrogen resistance 3 Hs.36958 [show with all ESTs]Unigene Representative Sequence: BC028477
GeneLoc Exon Structure
4 Ensembl transcripts including schematic representations: ENST00000260502
ENST00000370244
ENST00000370243
ENST00000370247
|
Expression for BCAR3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| BCAR3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for BCAR3
1 / 2 / 3 3 probe-sets matching BCAR3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AATGAAAATA
SOURCE GeneReport for Unigene cluster: Hs.36958
Expression variation in blood from EXPOLDB for BCAR3 UniProtKB/Swiss-Prot: BCAR3_HUMAN, O75815Tissue specificity: Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue |
Orthologs for BCAR3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BCAR3 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for BCAR3
ENSEMBL Gene Tree for BCAR3 | Paralogs for BCAR3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for BCAR3 gene
- SH2D3C2 SH2D3A2
|
SNPs/Variants for BCAR3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for BCAR3 (up to first 250kb)
|
Disorders & Mutations for BCAR3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604704
2 Novoseek disease relationships for BCAR3 gene
About this table
|
Medical News for BCAR3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for BCAR3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/29 PubMed articles for BCAR3 gene (see all 29
):- Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. (PubMed id 9582273)1, 2, 3, 4 van Agthoven T.... Dorssers L.C.J. (1998)
- NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway. (PubMed id 10187783)1, 3, 4 Lu Y.... Stewart T.A. (1999)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)3, 4 Beausoleil S.A.... Gygi S.P. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)3, 4 Clark H.F....Gray A. (2003)
- BCAR3 regulates EGF-induced DNA synthesis in normal human breast MCF-12A cells. (PubMed id 18722344)1, 3 Oh M.J....Jhun B.H. (2008)
- AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. (PubMed id 17427198)1, 3 Near R.I....Lerner A. (2007)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
|
Search for BCAR3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing BCAR3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing BCAR3
(According to HUGE)
About This Section
| |
Specialized Databases showing BCAR3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for BCAR3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for BCAR3:

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Incremental update: 13 Oct 2009
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