BCAR3 Gene

Aliases
for BCAR3 gene

Previous GC identifers: GC01M094433 GC01M093233 GC01M093377 GC01M093499 GC01M093739 GC01M093799 GC01M092148

Summaries
for BCAR3 gene

Genomic Views
for BCAR3 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_032977.9  

SwitchGear Promoter luciferase reporter plasmids (see all 5): BCAR3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCAR3

BCAR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M094027:  view genomic region     (about GC identifiers)

Proteins
for BCAR3 gene

1 PDB 3D structure from and Proteopedia for BCAR3:

3T6A (3D)    

Explore the universe of human proteins at neXtProt for BCAR3: NX_O75815

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: BCAR3 OriGene Protein Over-expression Lysate: BCAR3 OriGene Custom Protein Services for BCAR3
	GenScript Custom Purified and Recombinant Proteins Services for BCAR3
	Novus Biologicals BCAR3 Protein Novus Biologicals BCAR3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for BCAR3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: BCAR3 OriGene Custom Antibody Services for BCAR3
	GenScript Custom Superior Antibodies Services for BCAR3
	Novus Biologicals BCAR3 Antibodies
	Search for Antibodies for BCAR3 at Abcam
	Uscn Antibodies for BCAR3
	ThermoFisher Antibodies for BCAR3

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for BCAR3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for BCAR3

Protein Domains /
Families
for BCAR3 gene

ProtoNet protein and cluster: O75815

Function
for BCAR3 gene

miRNA Products:		OriGene 3'-UTR Clone: BCAR3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCAR3
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate BCAR3 (see all 15):
		hsa-miR-595 hsa-miR-222* hsa-miR-1237 hsa-miR-199b-3p hsa-miR-186* hsa-miR-199a-3p hsa-miR-487a hsa-miR-3129-5p
		SwitchGear 3'UTR luciferase reporter plasmid: BCAR3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCAR3 (see all 7) OriGene shRNA RFP: BCAR3 OriGene siRNA: BCAR3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCAR3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for BCAR3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCAR3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCAR3 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: BCAR3 (NM_003567)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAR3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAR3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BCAR3
		Search LifeMap BioReagents cell lines for BCAR3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Bcar3)

Pathways & Interactions
for BCAR3 gene

	Super-pathway	contained gene-specific pathways
1	Regulation of CDC42 activity	Regulation of CDC42 activity 1.00

1 BioSystems Pathway for BCAR3

Regulation of CDC42 activity

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for BCAR3 gene

Transcripts
for BCAR3 gene

Expression
for BCAR3 gene

BCAR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGAAAATA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Neural TubeMesencephalic Ventricular Zone			Neural Tube
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Definitive endoderm-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCAR3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCAR3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCAR3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCAR3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR3

Orthologs
for BCAR3 gene

Paralogs
for BCAR3 gene

Paralogs for BCAR3 gene

SH2D3C²  SH2D3A²  

3 SIMAP similar genes for BCAR3 using alignment to 2 protein entries:     BCAR3_HUMAN (see all proteins):

SHC3    SH2D3C    SH2D3A

BCAR3 for paralogs           About GeneDecksing

Genomic Variants
for BCAR3 gene

10/4740 NCBI SNPs in BCAR3 are shown (see all 4740)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs741016671,2	C,	--	92270395(+)	CACTTT/AAAAAA	1	--	us2k1		2		WA	120
rs1128105671,2	C,	--	92339569(+)	GCATAC/TGGTAT	1	--	ds5001		1		WA	2
rs796596081,2	F,	--	92339646(+)	CTGAGC/TTCTGT	1	--	ds5001		1		NA	120
rs66982421,2	C,F,H,	--	92339657(+)	GACATT/GTGTGA	1	--	ds5001		5		NS EA WA	500
rs45422181,2	C,F,A,H,	--	92339693(+)	CAGGAC/TGTTGG	1	--	ds5001		10		EA NS NA WA CSA	548
rs1134859481,2		--	92339980(+)	CAGTGA/CTAAGT	1	--	nc-transcript-variant		1		CSA	1
rs66814891,2	C,H,	--	92340108(+)	GTCTTG/ATCTCT	1	--	nc-transcript-variant		5		NS EA WA	536
rs741016961,2	C,	--	92340830(+)	ACACAC/TACACA	1	--	us2k1		1		WA	2
rs118078451,2	C,F,H,	--	92341189(+)	ACTGCT/CCAGTC	1	--	us2k1		2		NA WA	122
rs780474271,2	F,	--	92341992(+)	CTAATC/TGTGTG	1	--	us2k1		1		WA	118

HapMap Linkage Disequilibrium report for BCAR3 (94027347 - 94277347 bp, first 250kb of BCAR3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for BCAR3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCAR3

DNA2.0 Custom Variant and Variant Library Synthesis for BCAR3

Disorders / Diseases
for BCAR3 gene

5 diseases for BCAR3

2 Novoseek disease relationships for BCAR3 gene    About this table

Publications
for BCAR3 gene

PubMed articles for BCAR3 gene, integrated from 9 sources (see all 39): (articles sorted by number of sources associating them with BCAR3)

Utopia: connect your pdf to the dynamic world of online information

1. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. (PubMed id 9582273)^{1, 2, 3, 9} van Agthoven T.... Dorssers L.C.J. (1998)
2. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway. (PubMed id 10187783)^{1, 2, 9} Lu Y.... Stewart T.A. (1999)
3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
7. BCAR3 regulates EGF-induced DNA synthesis in normal human breast MCF-12A cells. (PubMed id 18722344)^{1, 9} Oh M.J....Jhun B.H. (2008)
8. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. (PubMed id 17427198)^{1, 9} Near R.I....Lerner A. (2007)
9. Breast cancer anti-estrogen resistance 3 (BCAR3) prote in augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas ). (PubMed id 22711540)¹ Makkinje A....Lerner A. (2012)
10. BCAR3/AND-34 can signal independent of complex format ion with CAS family members or the presence of p130Cas. (PubMed id 21262352)¹ Vanden Borre P....Lerner A. (2011)

External Searches for BCAR3 gene

Genome Databases showing BCAR3 gene

Other Databases showing BCAR3 gene

Specialized Databases showing BCAR3 gene

Products
for BCAR3 gene