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Aliases for BCAR3 Gene

Aliases for BCAR3 Gene

  • Breast Cancer Anti-Estrogen Resistance 3 2 3
  • SH2 Domain-Containing Protein 3B 3 4
  • Novel SH2-Containing Protein 2 3 4
  • SH2D3B 3 4
  • NSP2 3 4
  • DJ1033H22.2 (Breast Cancer Anti-Estrogen Resistance 3) 3
  • Breast Cancer Anti-Estrogen Resistance Protein 3 3
  • Breast Cancer Antiestrogen Resistance 3 Protein 3

External Ids for BCAR3 Gene

Previous GeneCards Identifiers for BCAR3 Gene

  • GC01M094433
  • GC01M093233
  • GC01M093377
  • GC01M093499
  • GC01M093739
  • GC01M093799
  • GC01M094027
  • GC01M092148

Summaries for BCAR3 Gene

Entrez Gene Summary for BCAR3 Gene

  • Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for BCAR3 Gene

BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) is a Protein Coding gene. Diseases associated with BCAR3 include venezuelan equine encephalitis and breast cancer. Among its related pathways are Regulation of CDC42 activity. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is SH2D3A.

UniProtKB/Swiss-Prot for BCAR3 Gene

  • May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.

Gene Wiki entry for BCAR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAR3 Gene

Genomics for BCAR3 Gene

Regulatory Elements for BCAR3 Gene

Genomic Location for BCAR3 Gene

Start:
93,561,786 bp from pter
End:
93,847,150 bp from pter
Size:
285,365 bases
Orientation:
Minus strand

Genomic View for BCAR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCAR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAR3 Gene

Proteins for BCAR3 Gene

  • Protein details for BCAR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75815-BCAR3_HUMAN
    Recommended name:
    Breast cancer anti-estrogen resistance protein 3
    Protein Accession:
    O75815
    Secondary Accessions:
    • D3DT43
    • Q5TEW3
    • Q6UW40
    • Q9BR50

    Protein attributes for BCAR3 Gene

    Size:
    825 amino acids
    Molecular mass:
    92566 Da
    Quaternary structure:
    • Interacts with BCAR1, NEDD9, PTK2/FAK1 and PTPN1.

    Three dimensional structures from OCA and Proteopedia for BCAR3 Gene

    Alternative splice isoforms for BCAR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCAR3 Gene

Proteomics data for BCAR3 Gene at MOPED

Post-translational modifications for BCAR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BCAR3 Gene

Domains for BCAR3 Gene

Gene Families for BCAR3 Gene

HGNC:
  • SH2D :SH2 domain containing

Suggested Antigen Peptide Sequences for BCAR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75815

UniProtKB/Swiss-Prot:

BCAR3_HUMAN :
  • O75815
Domain:
  • Contains 1 Ras-GEF domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with BCAR3: view

Function for BCAR3 Gene

Molecular function for BCAR3 Gene

UniProtKB/Swiss-Prot Function: May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.

Gene Ontology (GO) - Molecular Function for BCAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 16273093
genes like me logo Genes that share ontologies with BCAR3: view

Phenotypes for BCAR3 Gene

genes like me logo Genes that share phenotypes with BCAR3: view

Animal Models for BCAR3 Gene

MGI Knock Outs for BCAR3:

miRNA for BCAR3 Gene

miRTarBase miRNAs that target BCAR3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BCAR3 Gene

Localization for BCAR3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCAR3 Gene COMPARTMENTS Subcellular localization image for BCAR3 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BCAR3 Gene

Pathways for BCAR3 Gene

SuperPathways for BCAR3 Gene

genes like me logo Genes that share pathways with BCAR3: view

Pathways by source for BCAR3 Gene

1 BioSystems pathway for BCAR3 Gene

Gene Ontology (GO) - Biological Process for BCAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002089 lens morphogenesis in camera-type eye IEA --
GO:0007165 signal transduction TAS 9582273
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0033138 positive regulation of peptidyl-serine phosphorylation IEA --
GO:0042493 response to drug TAS 9582273
genes like me logo Genes that share ontologies with BCAR3: view

Compounds for BCAR3 Gene

(1) Novoseek inferred chemical compound relationships for BCAR3 Gene

Compound -log(P) Hits PubMed IDs
estrogen 14.7 2
genes like me logo Genes that share compounds with BCAR3: view

Transcripts for BCAR3 Gene

Unigene Clusters for BCAR3 Gene

Breast cancer anti-estrogen resistance 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCAR3 Gene

No ASD Table

Relevant External Links for BCAR3 Gene

GeneLoc Exon Structure for
BCAR3
ECgene alternative splicing isoforms for
BCAR3

Expression for BCAR3 Gene

mRNA expression in normal human tissues for BCAR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCAR3 Gene

SOURCE GeneReport for Unigene cluster for BCAR3 Gene Hs.36958

mRNA Expression by UniProt/SwissProt for BCAR3 Gene

O75815-BCAR3_HUMAN
Tissue specificity: Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue.
genes like me logo Genes that share expressions with BCAR3: view

No data available for mRNA differential expression in normal tissues for BCAR3 Gene

Orthologs for BCAR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BCAR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCAR3 35
  • 99.31 (n)
  • 99.03 (a)
BCAR3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BCAR3 35
  • 86.99 (n)
  • 86.67 (a)
BCAR3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCAR3 35
  • 86.91 (n)
  • 87.12 (a)
BCAR3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcar3 35
  • 84.57 (n)
  • 86.08 (a)
Bcar3 16
Bcar3 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCAR3 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
-- 36
  • 22 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Bcar3 35
  • 84.93 (n)
  • 85.94 (a)
chicken
(Gallus gallus)
Aves BCAR3 35
  • 68.67 (n)
  • 69.28 (a)
BCAR3 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCAR3 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcar3 35
  • 64.85 (n)
  • 65.26 (a)
zebrafish
(Danio rerio)
Actinopterygii bcar3 35
  • 61.9 (n)
  • 60.42 (a)
bcar3 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9098 36
  • 22 (a)
OneToMany
CG9098 37
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10354 36
  • 32 (a)
OneToMany
Species with no ortholog for BCAR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCAR3 Gene

ENSEMBL:
Gene Tree for BCAR3 (if available)
TreeFam:
Gene Tree for BCAR3 (if available)

Paralogs for BCAR3 Gene

Paralogs for BCAR3 Gene

Selected SIMAP similar genes for BCAR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BCAR3: view

Variants for BCAR3 Gene

Sequence variations from dbSNP and Humsavar for BCAR3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1848 -- 93,781,021(+) GGGCC(A/G)GTAGG intron-variant
rs1851 -- 93,781,043(+) AGCCA(C/G)CATGT intron-variant
rs1852 -- 93,781,055(+) TAGAG(C/T)TGTGG intron-variant
rs11683 -- 93,561,834(-) ATATG(A/G)AAAAT utr-variant-3-prime
rs23766 -- 93,566,540(-) CGGAT(C/T)TTTCT intron-variant

Relevant External Links for BCAR3 Gene

HapMap Linkage Disequilibrium report
BCAR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BCAR3 Gene

Disorders for BCAR3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for BCAR3 Gene including...

Search for BCAR3 Gene in MalaCards »

(2) Novoseek inferred disease relationships for BCAR3 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 45.4 8
tumors 0 1

Relevant External Links for BCAR3

Genetic Association Database (GAD)
BCAR3
Human Genome Epidemiology (HuGE) Navigator
BCAR3
genes like me logo Genes that share disorders with BCAR3: view

No data available for UniProtKB/Swiss-Prot for BCAR3 Gene

Publications for BCAR3 Gene

  1. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. (PMID: 9582273) van Agthoven T. … Dorssers L.C.J. (EMBO J. 1998) 2 3 4 23
  2. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway. (PMID: 10187783) Lu Y. … Stewart T.A. (J. Biol. Chem. 1999) 3 4 23
  3. BCAR3 regulates EGF-induced DNA synthesis in normal human breast MCF-12A cells. (PMID: 18722344) Oh M.J. … Jhun B.H. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. (PMID: 17427198) Near R.I. … Lerner A. (J. Cell. Physiol. 2007) 3 23
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for BCAR3 Gene

Sources for BCAR3 Gene

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