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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCAR3 Gene

protein-coding   GIFtS: 56
GCID: GC01M094027

Breast Cancer Anti-Estrogen Resistance 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Breast Cancer Anti-Estrogen Resistance 31 2     SH2 Domain-Containing Protein 3B2 3
Novel SH2-Containing Protein 22 3     Breast Cancer Anti-Estrogen Resistance Protein 32
NSP22 3     Breast Cancer Antiestrogen Resistance 3 Protein2
SH2D3B2 3     DJ1033H22.2 (Breast Cancer Anti-Estrogen Resistance 3)2

External Ids:    HGNC: 9731   Entrez Gene: 84122   Ensembl: ENSG000001379367   OMIM: 6047045   UniProtKB: O758153   

Export aliases for BCAR3 gene to outside databases

Previous GC identifers: GC01M094433 GC01M093233 GC01M093377 GC01M093499 GC01M093739 GC01M093799 GC01M092148


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCAR3 Gene:
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by
anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast
cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of
estrogen resistance. The gene encodes a component of intracellular signal transduction that causes
estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2
(SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell
division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, May 2012)

GeneCards Summary for BCAR3 Gene: 
BCAR3 (breast cancer anti-estrogen resistance 3) is a protein-coding gene. Diseases associated with BCAR3 include breast cancer, and venezuelan equine encephalitis. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is SH2D3C.

UniProtKB/Swiss-Prot: BCAR3_HUMAN, O75815
Function: May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that
regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in
breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins

Gene Wiki entry for BCAR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCAR3 gene promoter:
         STAT5A   HNF-3beta   CBF-C   AREB6   Ik-2   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): BCAR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for BCAR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCAR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1   Ensembl cytogenetic band:  1p22.1   HGNC cytogenetic band: 1p22.1

BCAR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCAR3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M094027:  view genomic region     (about GC identifiers)

Start:
94,027,347 bp from pter      End:
94,312,706 bp from pter
Size:
285,360 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BCAR3_HUMAN, O75815 (See protein sequence)
Recommended Name: Breast cancer anti-estrogen resistance protein 3  
Size: 825 amino acids; 92566 Da
Subunit: Interacts with BCAR1, NEDD9, PTK2/FAK1 and PTPN1 (By similarity)
1 PDB 3D structure from and Proteopedia for BCAR3:
3T6A (3D)    
Secondary accessions: D3DT43 Q5TEW3 Q6UW40 Q9BR50
Alternative splicing: 3 isoforms:  O75815-1   O75815-2   O75815-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BCAR3: NX_O75815

Explore proteomics data for BCAR3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75815

  • BCAR3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BCAR3 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001248337.1  NP_001248338.1  NP_001248339.1  NP_003558.1  

    ENSEMBL proteins: 
     ENSP00000359267   ENSP00000260502   ENSP00000359264   ENSP00000359263   ENSP00000441343  

    Human Recombinant Protein Products for BCAR3: 
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    Novus Biologicals BCAR3 Lysates
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for BCAR3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    BCAR3 for ontologies           About GeneDecksing



    BCAR3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    3 InterPro protein domains:
     IPR000980 SH2
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25

    Graphical View of Domain Structure for InterPro Entry O75815

    ProtoNet protein and cluster: O75815

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: BCAR3_HUMAN, O75815
    Similarity: Contains 1 Ras-GEF domain
    Similarity: Contains 1 SH2 domain


    BCAR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCAR3_HUMAN, O75815
    Function: May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that
    regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in
    breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding IPI16273093
         
    BCAR3 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bcar3):
     nervous system  vision/eye 

    BCAR3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bcar3tm1Lern for BCAR3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BCAR3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BCAR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCAR3 
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate BCAR3 (see all 15):
    hsa-miR-595 hsa-miR-222* hsa-miR-1237 hsa-miR-199b-3p hsa-miR-186* hsa-miR-199a-3p hsa-miR-487a hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmidBCAR3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BCAR3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of CDC42 activity
    Regulation of CDC42 activity


    1 BioSystems Pathway for BCAR3
        Regulation of CDC42 activity


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCAR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/128 Interacting proteins for BCAR3 (O758153 ENSP000002605024) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEDD9Q145113, ENSP000003687594I2D: score=3 STRING: ENSP00000368759
    BCAR1P569453, ENSP000001623304I2D: score=2 STRING: ENSP00000162330
    IMPDH2P122683, ENSP000003215844I2D: score=2 STRING: ENSP00000321584
    PABPC1P119403, ENSP000003130074I2D: score=2 STRING: ENSP00000313007
    PPP2R1AP301533, ENSP000003248044I2D: score=2 STRING: ENSP00000324804
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9582273
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0042493response to drug TAS9582273

    BCAR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BCAR3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BCAR3

    1 Novoseek inferred chemical compound relationship for BCAR3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 14.7 3 18351453 (1), 19075277 (1)

    Search CenterWatch for drugs/clinical trials and news about BCAR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BCAR3 gene (4 alternative transcripts): 
    NM_001261408.1  NM_001261409.1  NM_001261410.1  NM_003567.3  

    Unigene Cluster for BCAR3:

    Breast cancer anti-estrogen resistance 3
    Hs.36958  [show with all ESTs]
    Unigene Representative Sequence: BC028477
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370247(uc001dpy.3) ENST00000260502(uc001dqa.3) ENST00000370244(uc001dqb.3)
    ENST00000370243(uc001dpz.3) ENST00000538653 ENST00000466632 ENST00000490377
    ENST00000479503 ENST00000469315 ENST00000539242(uc001dpx.4 uc009wdm.1)

    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate BCAR3 (see all 15):
    hsa-miR-595 hsa-miR-222* hsa-miR-1237 hsa-miR-199b-3p hsa-miR-186* hsa-miR-199a-3p hsa-miR-487a hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmidBCAR3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF124250.1 AK027785.1 AK055442.1 AK301570.1 AK310970.1 AL833121.1 AY358996.1 BC028477.1 
    BC039895.1 U92715.1 

    11 DOTS entries:

    DT.75191686  DT.95248561  DT.99980444  DT.100784061  DT.92426182  DT.95116328  DT.121341346  DT.121341372 
    DT.91670568  DT.99949696  DT.92426183 

    24/165 AceView cDNA sequences (see all 165):

    AI613118 BI253306 AY358996 BE043094 NM_003567 AA112335 CA454914 CA453969 
    BQ014234 CN483733 CB132451 BU618526 BP342697 BI824100 CB120196 AK027785 
    BQ217872 BC039895 AF124250 CA442336 CR601884 BM463861 BU609135 BM849452 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCAR3 expression in normal human tissues (normalized intensities)      BCAR3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGAAAATA
    BCAR3 Expression
    About this image


    BCAR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone

     -- (Gastrointestinal Tract)
             visceral organ/oral region/gland   

    See BCAR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCAR3

    SOURCE GeneReport for Unigene cluster: Hs.36958

    UniProtKB/Swiss-Prot: BCAR3_HUMAN, O75815
    Tissue specificity: Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast
    tissue

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BCAR3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcar31 , 5 breast cancer anti-estrogen resistance 31, 5 84.57(n)1
    86.08(a)1
      3 (53.41 cM)5
    298151  NM_013867.21  NP_038895.11 
     1224197805 
    chicken
    (Gallus gallus)
    Aves BCAR31 breast cancer anti-estrogen resistance 3 68.99(n)
    69.4(a)
      424494  XM_422334.3  XP_422334.2 
    lizard
    (Anolis carolinensis)
    Reptilia BCAR36
    breast cancer anti-estrogen resistance 3
    63(a)
    1 ↔ 1
    4(88400579-88558171)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX739959.12   -- 74.34(n)    BX739959.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bcar31 breast cancer anti-estrogen resistance 3 61.94(n)
    60.3(a)
      570610  NM_001113620.1  NP_001107092.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90983 SH3/SH2 adaptor protein 34(a)   26B3   --


    ENSEMBL Gene Tree for BCAR3 (if available)
    TreeFam Gene Tree for BCAR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BCAR3 gene
    SH2D3C2  SH2D3A2  
    2 SIMAP similar genes for BCAR3 using alignment to 1 protein entry:     BCAR3_HUMAN:
    SH2D3C    SH2D3A

    BCAR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5246 SNPs in BCAR3 are shown (see all 5246)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs741016671,2
    C,F--92270395(+) CACTTT/AAAAAA 1 -- us2k12Minor allele frequency- A:0.07WA 120
    rs1920498171,2
    --92270425(+) AAAAGC/TTAAAT 1 -- us2k10--------
    rs1449007821,2
    --92270484(+) ACAGAG/TATGTA 1 -- us2k10--------
    rs171100631,2
    C,F,H--94026861(+) TCCAAA/GTTTTG 4 -- ds500118Minor allele frequency- G:0.13NA NS EA WA 2106
    rs1439123421,2
    --94026946(+) AACCTA/GGAAAG 4 -- ds50010--------
    rs1885025411,2
    --94027187(+) ACTCTG/TCCTTT 4 -- ds50010--------
    rs617840711,2
    C,F--94027203(+) CAGGAG/ACATTA 4 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1402488651,2
    --94027208(+) ACATTA/GAATTT 4 -- ds50010--------
    rs1502928701,2
    --94027227(+) ACTTTA/CATTCA 4 -- ds50010--------
    rs1918728511,2
    --94027263(+) ACCTAA/GGGAAG 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for BCAR3 (94027347 - 94277347 bp, first 250kb of BCAR3)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BCAR3: --
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604704    OMIM disorders: --

    4 diseases for BCAR3:    About MalaCards
    breast cancer    venezuelan equine encephalitis    chikungunya    encephalitis


    BCAR3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for BCAR3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 45.4 8 17427198 (2), 14583477 (2), 18722344 (2), 18351453 (1) (see all 5)
    tumors 0 1 19075277 (1)

    Genetic Association Database (GAD): BCAR3
    Human Genome Epidemiology (HuGE) Navigator: BCAR3 (3 documents)

    Export disorders for BCAR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BCAR3 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with BCAR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. (PubMed id 9582273)1, 2, 3, 9 van Agthoven T.... Dorssers L.C.J. (1998)
    2. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway. (PubMed id 10187783)1, 2, 9 Lu Y.... Stewart T.A. (1999)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. BCAR3 regulates EGF-induced DNA synthesis in normal human breast MCF-12A cells. (PubMed id 18722344)1, 9 Oh M.J....Jhun B.H. (2008)
    9. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. (PubMed id 17427198)1, 9 Near R.I....Lerner A. (2007)
    10. Breast cancer anti-estrogen resistance 3 (BCAR3) prote in augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas ). (PubMed id 22711540)1 Makkinje A....Lerner A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8412 HGNC: 973 AceView: BCAR3 Ensembl:ENSG00000137936 euGenes: HUgn8412
    ECgene: BCAR3 H-InvDB: BCAR3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BCAR3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCAR3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BCAR3 gene:
    Search GeneIP for patents involving BCAR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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