Aliases for BCAR3 Gene
External Ids for BCAR3 Gene
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for BCAR3 Gene
BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) is a Protein Coding gene. Diseases associated with BCAR3 include breast cancer and venezuelan equine encephalitis. Among its related pathways are Regulation of CDC42 activity. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is SH2D3A.
UniProtKB/Swiss-Prot for BCAR3 Gene
May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.