Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BCAR1 Gene

Aliases for BCAR1 Gene

  • BCAR1, Cas Family Scaffolding Protein 2 3 5
  • Cas Scaffolding Protein Family Member 1 2 3 4
  • Breast Cancer Anti-Estrogen Resistance 1 2 3
  • Crk-Associated Substrate 2 4
  • P130Cas 3 4
  • CASS1 3 4
  • CRKAS 3 4
  • CAS 3 4
  • Breast Cancer Anti-Estrogen Resistance Protein 1 3
  • Crk-Associated Substrate P130Cas 3
  • CAS1 3

External Ids for BCAR1 Gene

Previous GeneCards Identifiers for BCAR1 Gene

  • GC16M066192
  • GC16M076223
  • GC16M075001
  • GC16M075042
  • GC16M073820
  • GC16M075262
  • GC16M061013

Summaries for BCAR1 Gene

Entrez Gene Summary for BCAR1 Gene

  • BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]

GeneCards Summary for BCAR1 Gene

BCAR1 (BCAR1, Cas Family Scaffolding Protein) is a Protein Coding gene. Diseases associated with BCAR1 include Estrogen Resistance and Differentiating Neuroblastoma. Among its related pathways are Phospholipase-C Pathway and Plasma membrane estrogen receptor signaling. GO annotations related to this gene include protein kinase binding and SH3 domain binding. An important paralog of this gene is NEDD9.

UniProtKB/Swiss-Prot for BCAR1 Gene

  • Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

Gene Wiki entry for BCAR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAR1 Gene

Genomics for BCAR1 Gene

Regulatory Elements for BCAR1 Gene

Enhancers for BCAR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G075260 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.8 +3.3 3320 7.9 HDGF PKNOX1 MLX ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 YY1 BCAR1 ENSG00000259972 CTRB2 ENSG00000261783 TMEM170A TERF2IP LOC105371344
GH16G075233 1.3 ENCODE dbSUPER 26.5 +33.8 33770 1.7 HDGF PKNOX1 ATF1 MLX CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 BCAR1 CTRB2 ENSG00000261783 LOC100506281 ENSG00000280152
GH16G075303 1.6 Ensembl ENCODE dbSUPER 16.5 -39.4 -39423 7.9 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000261783 BCAR1 CFDP1 RNU6-758P ENSG00000259999
GH16G075241 1.8 FANTOM5 ENCODE dbSUPER 14.2 +17.6 17597 17.5 HNRNPUL1 HDGF PKNOX1 MLX ARNT CREB3L1 AGO1 ZFP64 ARID4B SIN3A BCAR1 ENSG00000261783 FA2H CHST6 ENSG00000280152 LOC105371344
GH16G075229 0.9 dbSUPER 26.6 +37.7 37745 1.9 ELF3 NFIB ZFP64 ZNF76 ARID4B SIN3A DMAP1 RAD21 ZSCAN9 ZNF48 BCAR1 CTRB2 ENSG00000252122 TMEM170A LOC100506281 ENSG00000280152
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BCAR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BCAR1 Gene

Chromosome:
16
Start:
75,228,187 bp from pter
End:
75,268,053 bp from pter
Size:
39,867 bases
Orientation:
Minus strand

Genomic View for BCAR1 Gene

Genes around BCAR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCAR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAR1 Gene

Proteins for BCAR1 Gene

  • Protein details for BCAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56945-BCAR1_HUMAN
    Recommended name:
    Breast cancer anti-estrogen resistance protein 1
    Protein Accession:
    P56945
    Secondary Accessions:
    • B3KWD7
    • B4DEV4
    • B4DGB5
    • B4DIW5
    • B7Z7X7
    • E9PCL5
    • E9PCV2
    • F5GXA2
    • F5GXV6
    • F5H7Z0
    • F8WA69
    • Q6QEF7

    Protein attributes for BCAR1 Gene

    Size:
    870 amino acids
    Molecular mass:
    93372 Da
    Quaternary structure:
    • Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase. Can heterodimerize with NEDD9. Interacts with BCAR3, the interaction regulates adhesion-dependent serine phosphorylation. Interacts with NPHP1 and SH2D3C. Interacts with activated CSPG4. Interacts with BMX, INPPL1/SHIP2 and PEAK1. Part of a collagen-stimulated complex involved in cell migration made of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with TNK2 via SH3 domains. Interacts with PTK2B/PYK2.

    Three dimensional structures from OCA and Proteopedia for BCAR1 Gene

    Alternative splice isoforms for BCAR1 Gene

neXtProt entry for BCAR1 Gene

Post-translational modifications for BCAR1 Gene

  • Dephosphorylated by PTPN14 at Tyr-128.
  • PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matrix.
  • Ubiquitination at Lys702
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BCAR1 (P130Cas)
  • Cloud-Clone Corp. Antibodies for BCAR1

No data available for DME Specific Peptides for BCAR1 Gene

Domains & Families for BCAR1 Gene

Gene Families for BCAR1 Gene

Graphical View of Domain Structure for InterPro Entry

P56945

UniProtKB/Swiss-Prot:

BCAR1_HUMAN :
  • Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9 (By similarity).
  • Belongs to the CAS family.
Domain:
  • Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9 (By similarity).
  • A serine-rich region promotes activation of the serum response element (SRE).
  • The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of PTK2/FAK11.
Family:
  • Belongs to the CAS family.
genes like me logo Genes that share domains with BCAR1: view

Function for BCAR1 Gene

Molecular function for BCAR1 Gene

UniProtKB/Swiss-Prot Function:
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

Gene Ontology (GO) - Molecular Function for BCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding IPI 9285683
GO:0017124 SH3 domain binding IEA --
GO:0019901 protein kinase binding IPI 8070403
genes like me logo Genes that share ontologies with BCAR1: view
genes like me logo Genes that share phenotypes with BCAR1: view

Animal Models for BCAR1 Gene

MGI Knock Outs for BCAR1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCAR1 Gene

Localization for BCAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCAR1 Gene

Cell junction, focal adhesion. Cytoplasm. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCAR1 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
plasma membrane 3
extracellular 2
endoplasmic reticulum 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 9472046
GO:0005737 cytoplasm IDA,IEA 8070403
GO:0005829 cytosol TAS --
GO:0005886 colocalizes_with plasma membrane IDA 21245381
GO:0005925 focal adhesion IDA,ISS --
genes like me logo Genes that share ontologies with BCAR1: view

Pathways & Interactions for BCAR1 Gene

genes like me logo Genes that share pathways with BCAR1: view

SIGNOR curated interactions for BCAR1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth TAS 11607844
GO:0007015 actin filament organization IDA 16105984
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction IEA --
GO:0007173 epidermal growth factor receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with BCAR1: view

Drugs & Compounds for BCAR1 Gene

(16) Drugs for BCAR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for BCAR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BCAR1: view

Transcripts for BCAR1 Gene

Unigene Clusters for BCAR1 Gene

Breast cancer anti-estrogen resistance 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCAR1 Gene

No ASD Table

Relevant External Links for BCAR1 Gene

GeneLoc Exon Structure for
BCAR1
ECgene alternative splicing isoforms for
BCAR1

Expression for BCAR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BCAR1 Gene

This gene is overexpressed in Testis (9.6), Plasma (9.5), Islet of Langerhans (9.1), Fetal Brain (7.3), Placenta (7.2), and Pancreas (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCAR1 Gene



Protein tissue co-expression partners for BCAR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BCAR1 Gene:

BCAR1

SOURCE GeneReport for Unigene cluster for BCAR1 Gene:

Hs.479747

mRNA Expression by UniProt/SwissProt for BCAR1 Gene:

P56945-BCAR1_HUMAN
Tissue specificity: Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.

Evidence on tissue expression from TISSUES for BCAR1 Gene

  • Eye(4.9)
  • Nervous system(4.9)
  • Bone(4.8)
  • Lung(4.7)
  • Skin(4.7)
  • Muscle(4.6)
  • Pancreas(4.3)
  • Kidney(4.1)
  • Intestine(3.9)
  • Blood(3.5)
  • Heart(3)
  • Liver(2.5)
genes like me logo Genes that share expression patterns with BCAR1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCAR1 Gene

Orthologs for BCAR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BCAR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCAR1 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia BCAR1 34 35
  • 88.34 (n)
cow
(Bos Taurus)
Mammalia BCAR1 34 35
  • 86.7 (n)
rat
(Rattus norvegicus)
Mammalia Bcar1 34
  • 85.31 (n)
mouse
(Mus musculus)
Mammalia Bcar1 34 16 35
  • 85.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BCAR1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves BCAR1 34 35
  • 72.39 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia bcar1 34
  • 59.58 (n)
Str.15275 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68466 34
zebrafish
(Danio rerio)
Actinopterygii bcar1 34 35
  • 65.18 (n)
Dr.4707 34
fruit fly
(Drosophila melanogaster)
Insecta p130CAS 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6681 35
  • 30 (a)
OneToMany
Species where no ortholog for BCAR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCAR1 Gene

ENSEMBL:
Gene Tree for BCAR1 (if available)
TreeFam:
Gene Tree for BCAR1 (if available)

Paralogs for BCAR1 Gene

Paralogs for BCAR1 Gene

Pseudogenes.org Pseudogenes for BCAR1 Gene

genes like me logo Genes that share paralogs with BCAR1: view

Variants for BCAR1 Gene

Sequence variations from dbSNP and Humsavar for BCAR1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_035798 A breast cancer sample
rs1000000831 -- 75,257,991(+) TAAAT(A/G)TACCC intron-variant
rs1000001749 -- 75,231,099(+) TAATC(C/T)TTTTT intron-variant
rs1000052574 -- 75,255,295(+) CTCTG(A/G)GAGCG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000105045 -- 75,259,902(+) AATAA(A/T)GCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCAR1 Gene

Variant ID Type Subtype PubMed ID
esv3582321 CNV loss 25503493
esv3582322 CNV loss 25503493
nsv149 OTHER inversion 15895083
nsv471095 CNV loss 18288195
nsv516504 CNV gain+loss 19592680
nsv523405 CNV loss 19592680
nsv7286 OTHER inversion 18451855
nsv833282 CNV gain+loss 17160897
nsv9459 CNV gain 18304495
nsv978002 CNV duplication 23825009

Variation tolerance for BCAR1 Gene

Residual Variation Intolerance Score: 75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.52; 71.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCAR1 Gene

Human Gene Mutation Database (HGMD)
BCAR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCAR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCAR1 Gene

Disorders for BCAR1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for BCAR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
estrogen resistance
  • estrogen insensitivity
differentiating neuroblastoma
breast cancer
  • breast cancer, invasive ductal
cerebral hypoxia
  • brain hypoxia
nephronophthisis 1, juvenile
  • nephronophthisis 1
- elite association - COSMIC cancer census association via MalaCards
Search BCAR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BCAR1

Genetic Association Database (GAD)
BCAR1
Human Genome Epidemiology (HuGE) Navigator
BCAR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCAR1
genes like me logo Genes that share disorders with BCAR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCAR1 Gene

Publications for BCAR1 Gene

  1. BCAR1, a human homologue of the adapter protein p130Cas, induces anti-estrogen resistance in breast cancer cells. (PMID: 10639512) Brinkman A. … Dorssers L.C.J. (J. Natl. Cancer Inst. 2000) 2 3 4 22 64
  2. The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity. (PMID: 15784259) Wisniewska M. … Engh R.A. (J. Mol. Biol. 2005) 3 4 22 64
  3. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. (PMID: 10587647) Eisenmann K.M. … Iida J. (Nat. Cell Biol. 1999) 3 4 22 64
  4. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. (PMID: 22081014) Mace P.D. … Riedl S.J. (Nat. Struct. Mol. Biol. 2011) 3 4 64
  5. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression. (PMID: 20534451) Wang Y. … Klemke R.L. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 64

Products for BCAR1 Gene

Sources for BCAR1 Gene

Content
Loading form....