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Set Analyses:

VarElect

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BCAR1 Gene

protein-coding GIFtS: 63
GCID: GC16M075262

Breast Cancer Anti-Estrogen Resistance 1

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Breast Cancer Anti-Estrogen Resistance 1¹ ²		CAS1²
Cas Scaffolding Protein Family Member 1¹ ² ³		P130Cas²
CAS² ³ ⁵		Breast Cancer Anti-Estrogen Resistance Protein 1²
CRKAS² ³ ⁵		Crk-Associated Substrate P130Cas²
CRK-Associated Substrate¹ ³		p130cas³
CASS1² ³

External Ids:	HGNC: 971¹	Entrez Gene: 9564²	Ensembl: ENSG00000050820⁷	OMIM: 602941⁵	UniProtKB: P56945³

Export aliases for BCAR1 gene to outside databases

Previous GC identifers: GC16M066192 GC16M076223 GC16M075001 GC16M075042 GC16M073820 GC16M061013

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BCAR1 Gene:

BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including

migration, survival, transformation, and invasion (Sawada et al., 2006 (PubMed 17129785)).(supplied by OMIM, May

2009)

GeneCards Summary for BCAR1 Gene:

BCAR1 (breast cancer anti-estrogen resistance 1) is a protein-coding gene. Diseases associated with BCAR1 include estrogen resistance, and cystic kidney. GO annotations related to this gene include SH3 domain binding and protein kinase binding. An important paralog of this gene is NEDD9.

UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945

Function: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to

cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on

breast cancer cells

Gene Wiki entry for BCAR1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000016.10 NT_010498.16 NC_018927.2

Regulatory elements:

Regulatory transcription factor binding sites in the BCAR1 gene promoter:
E2F-4 E2F-3a E2F-5 AP-1 ATF-2 E2F-2 LCR-F1 E2F-1 E2F c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): BCAR1 promoter sequence

Search Chromatin IP Primers for BCAR1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCAR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1 Ensembl cytogenetic band: 16q23.1 HGNC cytogenetic band: 16q22-q23

BCAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCAR1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M075262: view genomic region (about GC identifiers)

Start:	75,262,928 bp from pter	End:	75,301,951 bp from pter
Size:	39,024 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945 (See protein sequence)

Recommended Name: Breast cancer anti-estrogen resistance protein 1

Size: 870 amino acids; 93372 Da

Subunit: Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase. Can heterodimerize with

NEDD9. Interacts with BCAR3, the interaction regulates adhesion-dependent serine phosphorylation. Interacts with

NPHP1 and SH2D3C. Interacts with activated CSPG4. Interacts with BMX, INPPL1/SHIP2 and PEAK1. Part of a

collagen-stimulated complex involved in cell migration made of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with

TNK2 via SH3 domains. Interacts with PTK2B/PYK2

2 PDB 3D structures from and Proteopedia for BCAR1:

1WYX (3D)

3T6G (3D)

Secondary accessions: B3KWD7 B4DEV4 B4DGB5 B4DIW5 B7Z7X7 E9PCL5 E9PCV2 F5GXA2 F5GXV6 F5H7Z0

F8WA69 Q6QEF7

Alternative splicing: 8 isoforms: P56945-1 P56945-2 P56945-3 P56945-4 P56945-5 P56945-6 P56945-7 P56945-8

(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BCAR1: NX_P56945

Explore proteomics data for BCAR1 at MOPED

Post-translational modifications:

PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC

family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine

residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular

matrix¹

Dephosphorylated by PTPN14 at Tyr-128¹

Ubiquitination² at Lys702

Modification sites at PhosphoSitePlus

See BCAR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (9 alternative transcripts):

NP_001164185.1 NP_001164186.1 NP_001164187.1 NP_001164188.1 NP_001164189.1 NP_001164190.1 NP_001164191.1 NP_001164192.1

NP_055382.2

ENSEMBL proteins:

ENSP00000162330 ENSP00000455166 ENSP00000377074 ENSP00000440370 ENSP00000443841

ENSP00000391669 ENSP00000440415 ENSP00000392708 ENSP00000377072 ENSP00000454702

ENSP00000456625 ENSP00000455810 ENSP00000456929 ENSP00000458088 ENSP00000457457

ENSP00000457097 ENSP00000457231 ENSP00000442161

Reactome Protein details: P56945

BCAR1 Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for BCAR1 OriGene Protein Over-expression Lysate for BCAR1 OriGene MassSpec for BCAR1 OriGene Custom Protein Services for BCAR1
	GenScript Custom Purified and Recombinant Proteins Services for BCAR1
	Novus Biologicals BCAR1 Proteins Novus Biologicals BCAR1 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for BCAR1

BCAR1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of BCAR1
	R&D Systems Antibodies for BCAR1 (p130Cas)
	Cell Signaling Technology (CST) Antibodies for BCAR1 (P130Cas)
	OriGene Antibodies for BCAR1 OriGene Custom Antibody Services for BCAR1
	Novus Biologicals BCAR1 Antibodies
	Abcam antibodies for BCAR1
	Cloud-Clone Corp. Antibodies for BCAR1
	ThermoFisher Antibody for BCAR1
	LSBio Antibodies in human, mouse, rat for BCAR1

BCAR1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for BCAR1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for BCAR1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for BCAR1 Cloud-Clone Corp. CLIAs for BCAR1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

CASS: Cas scaffolding proteins

5 InterPro protein domains:

IPR014928 Serine_rich

IPR001452 SH3_domain

IPR028848 BCAR1

IPR013315 Spectrin_alpha_SH3

IPR021901 CAS_DUF3513

Graphical View of Domain Structure for InterPro Entry P56945

ProtoNet protein and cluster: P56945

1 Blocks protein domain: IPB001452 SH3 domain signature

UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945

Domain: Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a

C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK,

NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast

and mediates heterodimerization with NEDD9 (By similarity)

Domain: A serine-rich region promotes activation of the serum response element (SRE)

Domain: The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one

proline-rich region of PTK2/FAK11

Similarity: Belongs to the CAS family

Similarity: Contains 1 SH3 domain

BCAR1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: BCAR1_HUMAN, P56945

Function: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to

cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on

breast cancer cells

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	IEA	--
GO:0005515	protein binding	IPI	10339567
GO:0017124	SH3 domain binding	IEA	--
GO:0019901	protein kinase binding	IPI	10026197

BCAR1 for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Bcar1):

cardiovascular system	cellular	embryogenesis	growth/size/body	liver/biliary system
mortality/aging	muscle

BCAR1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Bcar1^tm1Hhi for BCAR1

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCAR1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCAR1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCAR1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCAR1

miRNA Products:		Block miRNA regulation of human, mouse, rat BCAR1 using miScript Target Protectors
		5 qRT-PCR Assays for microRNAs that regulate BCAR1:
		hsa-miR-148b* hsa-miR-3168 hsa-miR-3148 hsa-miR-105 hsa-miR-509-3p
		SwitchGear 3'UTR luciferase reporter plasmid: BCAR1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for BCAR1
		Predesigned siRNA for gene silencing in human, mouse, rat BCAR1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for BCAR1

Clone Products:		OriGene clones in human, mouse for BCAR1 (see all 41) OriGene ORF clones in mouse, rat for BCAR1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 9): BCAR1 (NM_001170714)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAR1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAR1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BCAR1
		Browse ESI BIO Cell Lines and PureStem Progenitors for BCAR1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

BCAR1_HUMAN, P56945: Cell junction, focal adhesion. Cytoplasm. Note=Unphosphorylated form localizes in the

cytoplasm and can move to the membrane upon tyrosine phosphorylation (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	4
plasma membrane	3
cytoskeleton	2
nucleus	2
mitochondrion	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IDA	9472046
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0005886	colocalizes with plasma membrane	IDA	--

BCAR1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for BCAR1 About (see all 44)

See pathways by source

SuperPath

Contained pathways About

Focal adhesion

	Focal adhesion	0.65			Integrin-mediated cell adhesion	0.38
	Focal Adhesion	0.65

Regulation of actin cytoskeleton

Regulation of actin cytoskeleton

0.57

Regulation of Actin Cytoskeleton

0.57

Chemokine Signaling

Chemokine signaling pathway

0.33

Chemokine Signaling

0.33

Integrin alphaIIb beta3 signaling

	Integrin alphaIIb beta3 signaling	0.73			p130Cas linkage to MAPK signaling for integrins	0.00
	Platelet Aggregation (Plug Formation)	0.73

Integrin Pathway

	FAK1 Signaling	0.67			Transendothelial Migration of Leukocytes	0.38
	Integrin Pathway	0.67

Pathways by source See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BCAR1 (see all 13)

	Chemokine Signaling
	MAPK Signaling
	Sertoli-Sertoli Cell Junction Dynamics
	Paxillin Interactions
	PTEN Pathway

2 Cell Signaling Technology (CST) Pathways for BCAR1

	Tyrosine Kinases / Adaptors
	Adhesion

Selected GeneGo (Thomson Reuters) Pathways for BCAR1 (see all 6)

	Cell adhesion PLAU signaling
	Cell adhesion Integrin-mediated cell adhesion and migration
	Signal transduction PTEN pathway
	Cytoskeleton remodeling FAK signaling
	Development Angiotensin signaling via PYK2

Selected BioSystems Pathways for BCAR1 (see all 23)

	Focal Adhesion
	Integrin-mediated cell adhesion
	EGFR1 Signaling Pathway
	Regulation of Actin Cytoskeleton
	B Cell Receptor Signaling Pathway

2 Reactome Pathways for BCAR1

	Downstream signal transduction
	p130Cas linkage to MAPK signaling for integrins

1 PharmGKB Pathway for BCAR1

Celecoxib Pathway, Pharmacodynamics

Selected Kegg Pathways (Kegg details for BCAR1) (see all 6):

	Rap1 signaling pathway
	Chemokine signaling pathway
	Focal adhesion
	Leukocyte transendothelial migration
	Regulation of actin cytoskeleton

BCAR1 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including BCAR1:

Estrogen Receptor Signaling in human mouse rat

EGF / PDGF Signaling Pathway in human mouse rat

Focal Adhesions in human mouse rat

Cell Motility in human mouse rat

Interactions:

GeneGlobe Interaction Network for BCAR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for BCAR1 (P56945^{1, 2, 3} ENSP00000162330⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 173)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRK	P46108¹^,²^,³, ENSP00000300574⁴	EBI-702093,EBI-886 MINT-6763936 MINT-7104340 MINT-7104448 I2D: score=7 STRING: ENSP00000300574
CRKL	P46109²^,³, ENSP00000346300⁴	MINT-8432380 I2D: score=2 STRING: ENSP00000346300
ACTB	P60709²^,³, ENSP00000349960⁴	MINT-6174734 I2D: score=1 STRING: ENSP00000349960
TNS3	Q68CZ2¹^,³, ENSP00000312143⁴	EBI-702093,EBI-1220488 I2D: score=1 STRING: ENSP00000312143
SFN	P31947²^,³	MINT-3974941 I2D: score=2

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Gene Ontology (GO): Selected biological process terms (see all 24): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	TAS	11607844
GO:0007015	actin filament organization	IDA	16105984
GO:0007155	cell adhesion	IEA	--
GO:0007173	epidermal growth factor receptor signaling pathway	ISS	--
GO:0007186	G-protein coupled receptor signaling pathway	NAS	10092204

BCAR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for BCAR1

Selected Novoseek inferred chemical compound relationships for BCAR1 gene (see all 27) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	81.8	270	9748296 (7), 9648724 (6), 7541040 (6), 9575907 (5) (see all 99)
cytochalasin d	65	8	7541040 (2), 7545676 (1), 9748296 (1), 12190987 (1) (see all 5)
phosphotyrosine	57	10	9422981 (1), 10739664 (1), 9032297 (1), 15044442 (1) (see all 9)
herbimycin a	47.8	6	9442079 (1)
phosphatidylinositol	44.3	9	9748296 (2), 10842093 (1), 19330798 (1), 10339567 (1) (see all 7)
k252a	34.4	2	10527630 (2)
proline	30.8	1	16289152 (1)
ganglioside	26.3	2	18078823 (1), 18538130 (1)
tamoxifen	26.3	13	16849545 (5), 19330798 (3), 10896938 (2), 15277346 (1) (see all 5)
calyculin a	24.9	5	9581808 (3), 11382927 (2)

BCAR1 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for BCAR1 gene (9 alternative transcripts):

NM_001170714.1 NM_001170715.1 NM_001170716.1 NM_001170717.1 NM_001170718.1 NM_001170719.1 NM_001170720.1 NM_001170721.1

NM_014567.3

Unigene Cluster for BCAR1:

Breast cancer anti-estrogen resistance 1

Hs.479747 [show with all ESTs]

Unigene Representative Sequence: AK124526

Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000162330(uc010vna.2 uc010cgu.3 uc002fdv.3 uc010vnd.2)

ENST00000562556 ENST00000563038(uc002fdt.3) ENST00000566982(uc002fdu.3)

ENST00000393422(uc002fdx.3) ENST00000535626(uc010vnc.2) ENST00000538440(uc002fdw.3)

ENST00000418647(uc010vnb.2) ENST00000542031 ENST00000420641 ENST00000393420

ENST00000569340 ENST00000564170 ENST00000568864 ENST00000564028 ENST00000566465

ENST00000569006 ENST00000561970

miRNA Products:		Block miRNA regulation of human, mouse, rat BCAR1 using miScript Target Protectors
		5 qRT-PCR Assays for microRNAs that regulate BCAR1:
		hsa-miR-148b* hsa-miR-3168 hsa-miR-3148 hsa-miR-105 hsa-miR-509-3p
		SwitchGear 3'UTR luciferase reporter plasmid: BCAR1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for BCAR1
		Predesigned siRNA for gene silencing in human, mouse, rat BCAR1

Clone Products:		OriGene clones in human, mouse for BCAR1 (see all 41) OriGene ORF clones in mouse, rat for BCAR1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 9): BCAR1 (NM_001170714)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAR1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAR1

Primer Products:		OriGene qPCR primer pairs and template standards for BCAR1 OriGene qSTAR qPCR primer pairs in human, mouse for BCAR1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat BCAR1
		QuantiTect SYBR Green Assays in human, mouse, rat BCAR1
		QuantiFast Probe-based Assays in human, mouse, rat BCAR1

Additional mRNA sequence:

AB040024.1 AF218451.1 AJ242987.2 AK026121.1 AK027608.1 AK074958.1 AK124526.1 AK124815.1

AK124844.1 AK125719.1 AK293808.1 AK294513.1 AK295809.1 AK302617.1 AK314722.1 AY545071.1

BC014402.1 BC062556.1

20 DOTS entries:

DT.100652053 DT.454557 DT.102840383 DT.95122178 DT.101984968 DT.100777466 DT.101984970 DT.86856714

DT.95079485 DT.207445 DT.100708641 DT.120680549 DT.120680602 DT.120680562 DT.95322529 DT.120680548

DT.120680552 DT.120680558 DT.120680563 DT.95090466

Selected AceView cDNA sequences (see all 339):

AI493518 BU541175 CB853295 AI077504 T35098 CF529919 AI983805 CF132221

BQ678580 BU538302 BG775027 BQ688682 BU157529 BM789120 BU542520 BM981125

AW166472 BM720377 BU838220 BM680418 BM468717 AI369230 BM700048 BF345455

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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BCAR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CACCACGGGC

About this image

BCAR1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Brain (Nervous System) fully expand to see all 3 entries
Cerebellum

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Ovary (Reproductive System)
Oviduct

BCAR1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

BCAR1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.479747

UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945

Tissue specificity: Widely expressed with an abundant expression in the testis. Low level of expression seen in

the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line

Pathway & Disease-focused RT² Profiler PCR Arrays including BCAR1:

Estrogen Receptor Signaling in human mouse rat

EGF / PDGF Signaling Pathway in human mouse rat

Focal Adhesions in human mouse rat

Cell Motility in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for BCAR1 OriGene qSTAR qPCR primer pairs in human, mouse for BCAR1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat BCAR1
		QuantiTect SYBR Green Assays in human, mouse, rat BCAR1
		QuantiFast Probe-based Assays in human, mouse, rat BCAR1

In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for BCAR1 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Bcar1^{1 , 5}	breast cancer anti-estrogen resistance 1^{1, 5}	85.22(n)¹ 90.18(a)¹		8 (57.98 cM)⁵ 12927¹ NM_009954.3¹ NP_034084.2¹ 111710485⁵
chicken (Gallus gallus)	Aves	BCAR1¹	breast cancer anti-estrogen resistance 1	72.39(n) 68.22(a)		415691 XM_414057.4 XP_414057.3
African clawed frog (Xenopus laevis)	Amphibia	MGC68466²	hypothetical protein MGC68466	74.29(n)		BC060334.1
zebrafish (Danio rerio)	Actinopterygii	Dr.4707²	Transcribed sequence with weak similarity to protein more	79.62(n)		AA495304.1
fruit fly (Drosophila melanogaster)	Insecta	p130CAS⁶	p130CAS	27(a)	1 → many	3L(152884-174517)

ENSEMBL Gene Tree for BCAR1 (if available)
TreeFam Gene Tree for BCAR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for BCAR1 gene

NEDD9² CASS4² EFS²

3 SIMAP similar genes for BCAR1 using alignment to 14 protein entries: BCAR1_HUMAN (see all proteins):

SH3GL2 ARHGEF7 NEDD9

BCAR1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for BCAR1
PGOHUM00000246616 PGOHUM00000246633

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_035798⁴		A breast cancer sample⁴	--	see VAR_035798	2	S T	mis⁴		0	--	--	--	--
rs140461283^1,2		--	75262468(+)	`TTCCGC/GAGGCT`	9	--	int¹		0	--	--	--	--
rs144423808^1,2		--	75262485(+)	`AGATTA/CTTTTA`	9	--	int¹		0	--	--	--	--
rs118039559^1,2	F	--	75262626(+)	`GGCAGC/TTCCCT`	9	--	int¹		1		NA	120
rs77276355^1,2	C	--	75262638(+)	`GGGTTG/ACAGGG`	9	--	int¹		4		NA WA EA	360
rs116990773^1,2	C,F	--	75262639(+)	`GGTTGC/AAGGGG`	9	--	int¹		1		NA	120
rs180785923^1,2		--	75262662(+)	`TGTGCA/TTTCTG`	9	--	int¹		0	--	--	--	--
rs117388570^1,2	F	--	75262673(+)	`GGCCCC/TAGACC`	9	--	int¹		1		NA	120
rs186205674^1,2		--	75262765(+)	`CCCCGA/CCTCCA`	9	--	int¹		0	--	--	--	--
rs191176577^1,2		--	75262868(+)	`CCCGGG/TTGCCT`	9	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BCAR1 (75262928 - 75301951 bp)

Structural Variations
Database of Genomic Variants (DGV) 10 variations for BCAR1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv471095	CNV	Loss	18288195
nsv523405	CNV	Loss	19592680
dgv2912n71	CNV	Loss	21882294
nsv906911	CNV	Loss	21882294
nsv906913	CNV	Loss	21882294
nsv9459	CNV	Gain	18304495
nsv833282	CNV	Gain+Loss	17160897
nsv516504	CNV	Gain+Loss	19592680
nsv7286	OTHER	Inversion	18451855
nsv149	OTHER	Inversion	15895083

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602941 OMIM disorders: --

Selected diseases for BCAR1 (see all 30):
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estrogen resistance cystic kidney differentiating neuroblastoma breast cancer

stomach cancer wiskott-aldrich syndrome neuroblastoma kidney disease

oral cancer kaposi's sarcoma lung adenocarcinoma peritonitis

astrocytoma coronary artery disease melanoma breast and colorectal cancer

endotheliitis sarcoma crohn's disease adenocarcinoma

BCAR1 for disorders About GeneDecksing

Selected Novoseek inferred disease relationships for BCAR1 gene (see all 13) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nphp1	76.2	1	10739664 (1)
cystic kidney disease	52.9	1	10739664 (1)
breast cancer	32.9	39	15277346 (5), 15448007 (4), 10639512 (3), 19940159 (2) (see all 15)
tumors	30.3	17	15448007 (3), 9927060 (1), 18842495 (1), 18845837 (1) (see all 12)
metastasis	29.9	7	18842495 (2), 18845837 (1), 19909363 (1), 19937461 (1) (see all 5)
colon cancer	21.6	2	14667936 (1), 18392556 (1)
cancer	19	3	19909363 (1), 19937461 (1), 18256281 (1)
melanoma	8.54	7	18078823 (2), 10587647 (2), 17185516 (1), 19937461 (1) (see all 5)
breast carcinoma	0	3	15020686 (1), 11605729 (1), 19103205 (1)
inflammation	0	1	12219172 (1)

Genetic Association Database (GAD): BCAR1
Human Genome Epidemiology (HuGE) Navigator: BCAR1 (1 document)

Export disorders for BCAR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BCAR1 gene, integrated from 10 sources (see all 402):
(articles sorted by number of sources associating them with BCAR1)

Utopia: connect your pdf to the dynamic
world of online information

BCAR1, a human homologue of the adapter protein p130Cas, induces anti-estrogen resistance in breast cancer cells. (PubMed id 10639512)^{1, 2, 3, 9} Brinkman A.... Dorssers L.C.J. (J. Natl. Cancer Inst. 2000)
The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity. (PubMed id 15784259)^{1, 2, 9} Wisniewska M.... Engh R.A. (J. Mol. Biol. 2005)
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. (PubMed id 10587647)^{1, 2, 9} Eisenmann K.M.... Iida J. (Nat. Cell Biol. 1999)
Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. (PubMed id 19086031)^{1, 2, 9} Rufanova V.A.... Sorokin A. (J. Cell. Physiol. 2009)
NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. (PubMed id 22081014)^{1, 2} Mace P.D.... Riedl S.J. (Nat. Struct. Mol. Biol. 2011)
Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PubMed id 19844255)^{1, 4} Dastani Z....Genest J. (Eur. J. Hum. Genet. 2010)
Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. (PubMed id 17038317)^{1, 2} Modzelewska K.... Keely P.J. (J. Biol. Chem. 2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading. (PubMed id 11158326)^{1, 2} Prasad N.... Decker S.J. (Mol. Cell. Biol. 2001)
Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site. (PubMed id 8413311)^{1, 3} Dorssers L.C....Kok E.M. (Mol. Endocrinol. 1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9564	HGNC: 971	AceView: BCAR1	Ensembl:ENSG00000050820	euGenes: HUgn9564
ECgene: BCAR1	Kegg: 9564	H-InvDB: BCAR1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for BCAR1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BCAR1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for BCAR1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BCAR1 gene:
Search GeneIP for patents involving BCAR1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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