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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCAR1 Gene

protein-coding   GIFtS: 63
GCID: GC16M075262

Breast Cancer Anti-Estrogen Resistance 1
  23 related diseases
at
MalaCards
 

Aliases
for BCAR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Breast Cancer Anti-Estrogen Resistance 11 2     CAS12
Cas Scaffolding Protein Family Member 11 2 3     P130Cas2
CAS2 3 5     Breast Cancer Anti-Estrogen Resistance Protein 12
CRKAS2 3 5     Crk-Associated Substrate P130Cas2
CRK-Associated Substrate1 3     p130cas3
CASS12 3     

External Ids:    HGNC: 9711   Entrez Gene: 95642   Ensembl: ENSG000000508207   OMIM: 6029415   UniProtKB: P569453   

Export aliases for BCAR1 gene to outside databases

Previous GC identifers: GC16M066192 GC16M076223 GC16M075001 GC16M075042 GC16M073820 GC16M061013


Summaries
for BCAR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BCAR1 Gene:
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration,
survival, transformation, and invasion (Sawada et al., 2006 (PubMed 17129785)).(supplied by OMIM, May 2009)

GeneCards Summary for BCAR1 Gene: 
BCAR1 (breast cancer anti-estrogen resistance 1) is a protein-coding gene. Diseases associated with BCAR1 include cystic kidney, and differentiating neuroblastoma, and among its related super-pathways are Focal Adhesion and Regulation of actin cytoskeleton. GO annotations related to this gene include SH3 domain binding and protein kinase binding. An important paralog of this gene is NEDD9.

UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945
Function: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell
adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer
cells

Gene Wiki entry for BCAR1 Gene


Genomic Views
for BCAR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCAR1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   ATF-2   E2F-2   LCR-F1   E2F-1   E2F   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): BCAR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for BCAR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCAR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q22-q23

BCAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCAR1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M075262:  view genomic region     (about GC identifiers)

Start:
 75,262,928 bp from pter      End:
 75,301,951 bp from pter
Size:
 39,024 bases      Orientation:
 minus strand

Proteins
for BCAR1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945 (See protein sequence)
Recommended Name: Breast cancer anti-estrogen resistance protein 1  
Size: 870 amino acids; 93372 Da
Subunit: Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase. Can heterodimerize with NEDD9.
Interacts with BCAR3, the interaction regulates adhesion-dependent serine phosphorylation. Interacts with NPHP1 and
SH2D3C. Interacts with activated CSPG4. Interacts with BMX, INPPL1/SHIP2 and PEAK1. Part of a collagen-stimulated
complex involved in cell migration made of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with TNK2 via SH3 domains.
Interacts with PTK2B/PYK2
Subcellular location: Cell junction, focal adhesion. Cytoplasm. Note=Unphosphorylated form localizes in the cytoplasm
and can move to the membrane upon tyrosine phosphorylation (By similarity)
2 PDB 3D structures from and Proteopedia for BCAR1:
1WYX (3D)        3T6G (3D)    
Secondary accessions: B3KWD7 B4DEV4 B4DGB5 B4DIW5 B7Z7X7 E9PCL5 E9PCV2 F5GXA2 F5GXV6 F5H7Z0 F8WA69
Q6QEF7
Alternative splicing: 8 isoforms:  P56945-1   P56945-2   P56945-3   P56945-4   P56945-5   P56945-6   P56945-7   P56945-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BCAR1: NX_P56945

Explore proteomics data for BCAR1 at MOPED 

Post-translational modifications:

  • UniProtKB: PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC
    • family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine
    residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matrix
  • UniProtKB: Dephosphorylated by PTPN14 at Tyr-128
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P56945

    • BCAR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BCAR1 Protein Expression
    REFSEQ proteins (9 alternative transcripts): 
    NP_001164185.1  NP_001164186.1  NP_001164187.1  NP_001164188.1  NP_001164189.1  NP_001164190.1  NP_001164191.1  NP_001164192.1  
    NP_055382.2  

    ENSEMBL proteins: 
     ENSP00000162330   ENSP00000455166   ENSP00000377074   ENSP00000440370   ENSP00000443841  
     ENSP00000391669   ENSP00000440415   ENSP00000392708   ENSP00000377072   ENSP00000454702  
     ENSP00000456625   ENSP00000455810   ENSP00000456929   ENSP00000458088   ENSP00000457457  
     ENSP00000457097   ENSP00000457231   ENSP00000442161  
    Reactome Protein details: P56945
    Human Recombinant Protein Products for BCAR1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BCAR1
    OriGene Protein Over-expression Lysate for BCAR1
    OriGene MassSpec for BCAR1 
    OriGene Custom Protein Services for BCAR1
    GenScript Custom Purified and Recombinant Proteins Services for BCAR1
    Novus Biologicals BCAR1 Proteins
    Novus Biologicals BCAR1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BCAR1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA9472046
    GO:0005737cytoplasm IDA8070403
    GO:0005829cytosol TAS--
    GO:0005886colocalizes with plasma membrane IDA--
    GO:0005925focal adhesion ISS--

    BCAR1 for ontologies           About GeneDecksing



    BCAR1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BCAR1
    R&D Systems Antibodies for BCAR1 (p130Cas)
    Cell Signaling Technology (CST) Antibodies for BCAR1  (P130Cas)
    OriGene Antibodies for BCAR1
    OriGene Custom Antibody Services for BCAR1
    GenScript Custom Superior Antibodies Services for BCAR1
    Novus Biologicals BCAR1 Antibodies
    Abcam antibodies for BCAR1
    Cloud-Clone Corp. Antibodies for BCAR1 
    ThermoFisher Antibody for BCAR1
    LSBio Antibodies in human, mouse, rat for BCAR1 

    Assay Products for BCAR1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BCAR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BCAR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BCAR1 
    Cloud-Clone Corp. CLIAs for BCAR1

    Protein Domains /
    Families
    for BCAR1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    CASS: Cas scaffolding proteins

    4 InterPro protein domains:
     IPR013315 Spectrin_alpha_SH3
     IPR021901 CAS_DUF3513
     IPR014928 Serine_rich
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry P56945

    ProtoNet protein and cluster: P56945

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945
    Domain: Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal
    domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL1
    SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates
    heterodimerization with NEDD9 (By similarity)
    Domain: A serine-rich region promotes activation of the serum response element (SRE)
    Domain: The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one
    proline-rich region of PTK2/FAK11
    Similarity: Belongs to the CAS family
    Similarity: Contains 1 SH3 domain


    BCAR1 for domains           About GeneDecksing


    Function
    for BCAR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCAR1_HUMAN, P56945
    Function: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell
    adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer
    cells

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS8070403
    GO:0005515protein binding IPI10339567
    GO:0017124SH3 domain binding IEA--
    GO:0019901protein kinase binding IPI10026197
         
    BCAR1 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Bcar1):
     cardiovascular system  cellular  embryogenesis  growth/size  liver/biliary system 
     mortality/aging  muscle 

    BCAR1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Bcar1tm1Hhi for BCAR1
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BCAR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BCAR1

    miRNA
    Products:        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCAR1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate BCAR1:
    hsa-miR-148b* hsa-miR-3168 hsa-miR-3148 hsa-miR-105 hsa-miR-509-3p
    SwitchGear 3'UTR luciferase reporter plasmid: BCAR1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BCAR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCAR1
    Sirion Biotech Custom design and validation of potent shRNA sequences against BCAR1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for BCAR1
    Sirion Biotech Customized adenovirus for overexpression of BCAR1
                         Customized adenovirus for potent knockdown of BCAR1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for BCAR1 (see all 29)
    OriGene ORF clones in mouse, rat for BCAR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 9): BCAR1 (NM_001170714)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAR1

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for BCAR1
    Search LifeMap BioReagents cell lines for BCAR1
    Sirion Biotech Customized stable knockdown cell line services for BCAR1
                         Customized inducible knockdown cell line services for BCAR1
                         Customized stable overexpressing cell line services for BCAR1
                         Customized inducible overexpressing cell line services for BCAR1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR1


    Pathways & Interactions
    for BCAR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BCAR1 About   (see all 45)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    		Focal Adhesion0.64
    		Integrin-mediated cell adhesion0.38
    		Focal adhesion0.64
    2Regulation of Actin Cytoskeleton
    		Regulation of Actin Cytoskeleton0.57
    		Regulation of actin cytoskeleton0.57
    3Chemokine Signaling
    		Chemokine Signaling0.33
    		Chemokine signaling pathway0.33
    4Integrin Pathway
    		Integrin Pathway0.67
    		Transendothelial Migration of Leukocytes0.38
    		FAK1 Signaling0.67
    5Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics0.38
    		Epithelial Tight Junctions0.36
    		Germ Cell-Sertoli Cell Junction Dynamics0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for BCAR1 (see all 6)
        Development Angiotensin signaling via PYK2
    Cell adhesion Integrin-mediated cell adhesion and migration
    Chemotaxis CXCR4 signaling pathway
    Signal transduction PTEN pathway
    Cell adhesion PLAU signaling

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BCAR1 (see all 13)
        Chemokine Signaling
    MAPK Signaling
    Sertoli-Sertoli Cell Junction Dynamics
    Paxillin Interactions
    PTEN Pathway

    2 Cell Signaling Technology (CST) Pathways for BCAR1
        Tyrosine Kinases / Adaptors
    Adhesion

    5/6 GeneGo (Thomson Reuters) Pathways for BCAR1 (see all 6)
        Cell adhesion PLAU signaling
    Cell adhesion Integrin-mediated cell adhesion and migration
    Signal transduction PTEN pathway
    Cytoskeleton remodeling FAK signaling
    Development Angiotensin signaling via PYK2

    5/23 BioSystems Pathways for BCAR1 (see all 23)
        Focal Adhesion
    EGFR1 Signaling Pathway
    Integrin-mediated cell adhesion
    Regulation of Actin Cytoskeleton
    B Cell Receptor Signaling Pathway

    5/9        Reactome Pathways for BCAR1 (see all 9)
        Hemostasis
    Downstream signal transduction
    Integrin cell surface interactions
    Integrin alphaIIb beta3 signaling
    Signal Transduction

    1 PharmGKB Pathway for BCAR1
        Celecoxib Pathway, Pharmacodynamics

    5         Kegg Pathways  (Kegg details for BCAR1):
        Chemokine signaling pathway
    Focal adhesion
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells


    BCAR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCAR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/170 Interacting proteins for BCAR1 (P569451, 2, 3 ENSP000001623304) via UniProtKB, MINT, STRING, and/or I2D (see all 170)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461081, 2, 3, ENSP000003005744EBI-702093,EBI-886 MINT-6763936 MINT-7104340 MINT-7104448 I2D: score=7 STRING: ENSP00000300574
    CRKLP461092, 3, ENSP000003463004MINT-8432380 I2D: score=2 STRING: ENSP00000346300
    ACTBP607092, 3, ENSP000003499604MINT-6174734 I2D: score=1 STRING: ENSP00000349960
    TNS3Q68CZ21, 3, ENSP000003121434EBI-702093,EBI-1220488 I2D: score=1 STRING: ENSP00000312143
    SFNP319472, 3MINT-3974941 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth TAS11607844
    GO:0007015actin filament organization IDA16105984
    GO:0007155cell adhesion IEA--
    GO:0007173epidermal growth factor receptor signaling pathway ISS--
    GO:0007186G-protein coupled receptor signaling pathway NAS10092204

    BCAR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BCAR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BCAR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BCAR1

    10/27 Novoseek inferred chemical compound relationships for BCAR1 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 81.8 270 9748296 (7), 9648724 (6), 7541040 (6), 9575907 (5) (see all 99)
    cytochalasin d 65 8 7541040 (2), 7545676 (1), 9748296 (1), 12190987 (1) (see all 5)
    phosphotyrosine 57 10 9422981 (1), 10739664 (1), 9032297 (1), 15044442 (1) (see all 9)
    herbimycin a 47.8 6 9442079 (1)
    phosphatidylinositol 44.3 9 9748296 (2), 10842093 (1), 19330798 (1), 10339567 (1) (see all 7)
    k252a 34.4 2 10527630 (2)
    proline 30.8 1 16289152 (1)
    ganglioside 26.3 2 18078823 (1), 18538130 (1)
    tamoxifen 26.3 13 16849545 (5), 19330798 (3), 10896938 (2), 15277346 (1) (see all 5)
    calyculin a 24.9 5 9581808 (3), 11382927 (2)

    Search CenterWatch for drugs/clinical trials and news about BCAR1

    Transcripts
    for BCAR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BCAR1 gene (9 alternative transcripts): 
    NM_001170714.1  NM_001170715.1  NM_001170716.1  NM_001170717.1  NM_001170718.1  NM_001170719.1  NM_001170720.1  NM_001170721.1  
    NM_014567.3  

    Unigene Cluster for BCAR1:

    Breast cancer anti-estrogen resistance 1
    Hs.479747  [show with all ESTs]
    Unigene Representative Sequence: AK124526
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000162330(uc010vna.2 uc010cgu.3 uc002fdv.3 uc010vnd.2)
    ENST00000562556 ENST00000563038(uc002fdt.3) ENST00000566982(uc002fdu.3)
    ENST00000393422(uc002fdx.3) ENST00000535626(uc010vnc.2) ENST00000538440(uc002fdw.3)
    ENST00000418647(uc010vnb.2) ENST00000542031 ENST00000420641 ENST00000393420
    ENST00000569340 ENST00000564170 ENST00000568864 ENST00000564028 ENST00000566465
    ENST00000569006 ENST00000561970
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate BCAR1:
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    SwitchGear 3'UTR luciferase reporter plasmid: BCAR1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for BCAR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCAR1
    Sirion Biotech Custom design and validation of potent shRNA sequences against BCAR1
    Clone
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    OriGene ORF clones in mouse, rat for BCAR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 9): BCAR1 (NM_001170714)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAR1
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCAR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCAR1

    Additional mRNA sequence: 

    AB040024.1 AF218451.1 AJ242987.2 AK026121.1 AK027608.1 AK074958.1 AK124526.1 AK124815.1 
    AK124844.1 AK125719.1 AK293808.1 AK294513.1 AK295809.1 AK302617.1 AK314722.1 AY545071.1 
    BC014402.1 BC062556.1 

    20 DOTS entries:

    DT.100652053  DT.454557  DT.102840383  DT.95122178  DT.101984968  DT.100777466  DT.101984970  DT.86856714 
    DT.95079485  DT.207445  DT.100708641  DT.120680549  DT.120680602  DT.120680562  DT.95322529  DT.120680548 
    DT.120680552  DT.120680558  DT.120680563  DT.95090466 

    24/339 AceView cDNA sequences (see all 339):

    CN478831 BQ222109 BM461632 AW166472 BQ574381 BM680418 AK125719 BQ771939 
    AW516899 BQ688682 BQ447600 AI077504 BM468717 CF529831 BM792707 BU838220 
    T35098 AI983805 BF345455 BM798009 BM981125 CA418835 CB853295 CR622696 

    GeneLoc Exon Structure


    Expression
    for BCAR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCAR1 expression in normal human tissues (normalized intensities)      BCAR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCACGGGC
    BCAR1 Expression
    About this image


    BCAR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 27 entries
             Thalamus
             Septum
     
     Reproductive System (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn
     
     Thyroid (Endocrine System)    fully expand to see all 2 entries
             thyroid gland ; glandular cells
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             epididymis ; glandular cells

    See BCAR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCAR1

    SOURCE GeneReport for Unigene cluster: Hs.479747

    UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945
    Tissue specificity: Widely expressed with an abundant expression in the testis. Low level of expression seen in the
    liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line

        SABiosciences Expression via Pathway-Focused PCR Arrays including BCAR1: 
              Estrogen Receptor Signaling in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

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    Orthologs
    for BCAR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for BCAR1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Bcar11 , 5 breast cancer anti-estrogen resistance 11, 5 85.64(n)1
    91.22(a)1    		   8 (57.98 cM)5
    129271  NM_001198839.11  NP_001185768.11 
     1117104855 
    chicken
    (Gallus gallus)    		 Aves BCAR11 breast cancer anti-estrogen resistance 1 72.78(n)
    69.04(a)    		   415691  XM_414057.3  XP_414057.3 
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC684662 hypothetical protein MGC68466 74.29(n)    BC060334.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.47072 Transcribed sequence with weak similarity to protein more 79.62(n)    AA495304.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta p130CAS1 CG1212-PB 45.47(n)
    32.55(a)    		   38021  NM_001103986.3  NP_001097456.2 


    ENSEMBL Gene Tree for BCAR1 (if available)
    TreeFam Gene Tree for BCAR1 (if available)

    Paralogs
    for BCAR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BCAR1 gene
    NEDD92  CASS42  EFS2  
    3 SIMAP similar genes for BCAR1 using alignment to 14 protein entries:     BCAR1_HUMAN (see all proteins):
    SH3GL2    ARHGEF7    NEDD9

    BCAR1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for BCAR1
    PGOHUM00000246616 PGOHUM00000246633


    Genomic Variants
    for BCAR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1205 SNPs in BCAR1 are shown (see all 1205)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0357984
    		A breast cancer sample4--see VAR_0357982 S T mis40--------
    rs1404612831,2
    		--75262468(+) TTCCGC/GAGGCT 9 -- int10--------
    rs1444238081,2
    		--75262485(+) AGATTA/CTTTTA 9 -- int10--------
    rs1180395591,2
    		F--75262626(+) GGCAGC/TTCCCT 9 -- int11Minor allele frequency- T:0.03NA 120
    rs772763551,2
    		C--75262638(+) GGGTTG/ACAGGG 9 -- int14Minor allele frequency- A:0.10NA WA EA 360
    rs1169907731,2
    		C,F--75262639(+) GGTTGC/AAGGGG 9 -- int11Minor allele frequency- A:0.02NA 120
    rs1807859231,2
    		--75262662(+) TGTGCA/TTTCTG 9 -- int10--------
    rs1173885701,2
    		F--75262673(+) GGCCCC/TAGACC 9 -- int11Minor allele frequency- T:0.01NA 120
    rs1862056741,2
    		--75262765(+) CCCCGA/CCTCCA 9 -- int10--------
    rs1911765771,2
    		--75262868(+) CCCGGG/TTGCCT 9 -- int10--------

    HapMap Linkage Disequilibrium report for BCAR1 (75262928 - 75301951 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for BCAR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471095CNV Loss18288195
    nsv523405CNV Loss19592680
    dgv2912n71CNV Loss21882294
    nsv906911CNV Loss21882294
    nsv906913CNV Loss21882294
    nsv9459CNV Gain18304495
    nsv833282CNV Gain+Loss17160897
    nsv516504CNV Gain+Loss19592680
    nsv7286OTHER Inversion18451855
    nsv149OTHER Inversion15895083

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    Disorders / Diseases
    for BCAR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BCAR1 for disorders           About GeneDecksing

    OMIM gene information: 602941    OMIM disorders: --

    20/23 diseases for BCAR1 (see all 23):    About MalaCards
    cystic kidney    differentiating neuroblastoma    breast cancer    stomach cancer
    wiskott-aldrich syndrome    neuroblastoma    kaposi's sarcoma    colon cancer
    lung adenocarcinoma    oral cancer    peritonitis    astrocytoma
    kidney disease    endotheliitis    sarcoma    melanoma
    thyroiditis    adenocarcinoma    hepatocellular carcinoma    lung cancer

    10/13 Novoseek inferred disease relationships for BCAR1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nphp1 76.2 1 10739664 (1)
    cystic kidney disease 52.9 1 10739664 (1)
    breast cancer 32.9 39 15277346 (5), 15448007 (4), 10639512 (3), 19940159 (2) (see all 15)
    tumors 30.3 17 15448007 (3), 9927060 (1), 18842495 (1), 18845837 (1) (see all 12)
    metastasis 29.9 7 18842495 (2), 18845837 (1), 19909363 (1), 19937461 (1) (see all 5)
    colon cancer 21.6 2 14667936 (1), 18392556 (1)
    cancer 19 3 19909363 (1), 19937461 (1), 18256281 (1)
    melanoma 8.54 7 18078823 (2), 10587647 (2), 17185516 (1), 19937461 (1) (see all 5)
    breast carcinoma 0 3 15020686 (1), 11605729 (1), 19103205 (1)
    inflammation 0 1 12219172 (1)

    Genetic Association Database (GAD): BCAR1
    Human Genome Epidemiology (HuGE) Navigator: BCAR1 (1 document)

    Export disorders for BCAR1 gene to outside databases

    Publications
    for BCAR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BCAR1 gene, integrated from 9 sources (see all 399):
    (articles sorted by number of sources associating them with BCAR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. BCAR1, a human homologue of the adapter protein p130Cas, induces anti-estrogen resistance in breast cancer cells. (PubMed id 10639512)1, 2, 3, 9 Brinkman A.... Dorssers L.C.J. (2000)
    2. The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity. (PubMed id 15784259)1, 2, 9 Wisniewska M....Engh R.A. (2005)
    3. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. (PubMed id 10587647)1, 2, 9 Eisenmann K.M.... Iida J. (1999)
    4. Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. (PubMed id 19086031)1, 2, 9 Rufanova V.A....Sorokin A. (2009)
    5. NSP-Cas protein structures reveal a promiscuous inter action module in cell signaling. (PubMed id 22081014)1, 2 Mace P.D....Riedl S.J. (2011)
    6. Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (2010)
    7. Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. (PubMed id 17038317)1, 2 Modzelewska K....Keely P.J. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading. (PubMed id 11158326)1, 2 Prasad N.... Decker S.J. (2001)
    10. Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site. (PubMed id 8413311)1, 3 Dorssers L.C....Kok E.M. (1993)

    External Searches for BCAR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BCAR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9564 HGNC: 971 AceView: BCAR1 Ensembl:ENSG00000050820 euGenes: HUgn9564
    ECgene: BCAR1 Kegg: 9564 H-InvDB: BCAR1

    Other Databases showing BCAR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BCAR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BCAR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCAR1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for BCAR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BCAR1 gene:
    Search GeneIP for patents involving BCAR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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