Aliases for BCAR1 Gene
External Ids for BCAR1 Gene
Previous GeneCards Identifiers for BCAR1 Gene
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]
GeneCards Summary for BCAR1 Gene
BCAR1 (BCAR1, Cas Family Scaffolding Protein) is a Protein Coding gene. Diseases associated with BCAR1 include Estrogen Resistance and Breast Cancer. Among its related pathways are Integrin alphaIIb beta3 signaling and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein kinase binding and SH3 domain binding. An important paralog of this gene is NEDD9.
UniProtKB/Swiss-Prot for BCAR1 Gene
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.