Aliases for BCAR1 Gene
Aliases for BCAR1 Gene
External Ids for BCAR1 Gene
- HGNC: 971
- Entrez Gene: 9564
- Ensembl: ENSG00000050820
- OMIM: 602941
- UniProtKB: P56945
Previous GeneCards Identifiers for BCAR1 Gene
- GC16M066192
- GC16M076223
- GC16M075001
- GC16M075042
- GC16M073820
- GC16M075262
- GC16M061013
Summaries for BCAR1 Gene
-
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]
GeneCards Summary for BCAR1 Gene
BCAR1 (BCAR1, Cas Family Scaffolding Protein) is a Protein Coding gene. Diseases associated with BCAR1 include Estrogen Resistance and Differentiating Neuroblastoma. Among its related pathways are Phospholipase-C Pathway and Plasma membrane estrogen receptor signaling. GO annotations related to this gene include protein kinase binding and SH3 domain binding. An important paralog of this gene is NEDD9.
UniProtKB/Swiss-Prot for BCAR1 Gene
-
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAR1 Gene
Genomics for BCAR1 Gene
Regulatory Elements for BCAR1 Gene
Enhancers for BCAR1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around BCAR1 on UCSC Golden Path with GeneCards custom track
Genomic Location for BCAR1 Gene
- Chromosome:
- 16
- Start:
- 75,228,187 bp from pter
- End:
- 75,268,053 bp from pter
- Size:
- 39,867 bases
- Orientation:
- Minus strand
Genomic View for BCAR1 Gene
Genes around BCAR1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q23.1 by Ensembl
- 16q23.1 by Entrez Gene
- 16q23.1 by HGNC
BCAR1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCAR1 Gene
Proteins for BCAR1 Gene
-
Protein details for BCAR1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P56945-BCAR1_HUMAN
- Recommended name:
- Breast cancer anti-estrogen resistance protein 1
- Protein Accession:
- P56945
- B3KWD7
- B4DEV4
- B4DGB5
- B4DIW5
- B7Z7X7
- E9PCL5
- E9PCV2
- F5GXA2
- F5GXV6
- F5H7Z0
- F8WA69
- Q6QEF7
Protein attributes for BCAR1 Gene
- Size:
- 870 amino acids
- Molecular mass:
- 93372 Da
- Quaternary structure:
-
- Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase. Can heterodimerize with NEDD9. Interacts with BCAR3, the interaction regulates adhesion-dependent serine phosphorylation. Interacts with NPHP1 and SH2D3C. Interacts with activated CSPG4. Interacts with BMX, INPPL1/SHIP2 and PEAK1. Part of a collagen-stimulated complex involved in cell migration made of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with TNK2 via SH3 domains. Interacts with PTK2B/PYK2.
Protein Expression for BCAR1 Gene
Post-translational modifications for BCAR1 Gene
- Dephosphorylated by PTPN14 at Tyr-128.
- PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matrix.
- Ubiquitination at Lys702
- Modification sites at PhosphoSitePlus
Other Protein References for BCAR1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for BCAR1 (p130Cas)
- Cell Signaling Technology (CST) Antibodies for BCAR1 (P130Cas)
- Novus Biologicals Antibodies for BCAR1
-
Cloud-Clone Corp. Antibodies for BCAR1
- Invitrogen Antibodies for BCAR1
- antibodies-online Antibodies for BCAR1: See all 187
- GeneTex BCAR1 antibody for BCAR1
-
Santa Cruz Biotechnology (SCBT) Antibodies for BCAR1
Protein Products
-
OriGene Purified Proteins for BCAR1
- Search Origene for MassSpec and Protein Over-expression Lysates for BCAR1
- Origene Custom Protein Services for BCAR1
- ProSpec Recombinant Proteins for BCAR1
-
Cloud-Clone Corp. Proteins for BCAR1
- antibodies-online Proteins for BCAR1: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for BCAR1
No data available for DME Specific Peptides for BCAR1 Gene
Domains & Families for BCAR1 Gene
Gene Families for BCAR1 Gene
Protein Domains for BCAR1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for BCAR1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ42535 fis, clone BRACE3003595, highly similar to Breast cancer anti-estrogen resistance protein 1 (B3KW85_HUMAN)
- cDNA FLJ55515, highly similar to Breast cancer anti-estrogen resistanceprotein 1 (B4DIW5_HUMAN)
- p130cas (BCAR1_HUMAN)
- Breast cancer anti-estrogen resistance 1, isoform CRA_a (D3DUK1_HUMAN)
- Breast cancer anti-estrogen resistance 1 (Q6P5Z4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P56945UniProtKB/Swiss-Prot:
BCAR1_HUMAN :- Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9 (By similarity).
- Belongs to the CAS family.
- Domain:
-
- Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9 (By similarity).
- A serine-rich region promotes activation of the serum response element (SRE).
- The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of PTK2/FAK11.
- Family:
-
- Belongs to the CAS family.
Function for BCAR1 Gene
Molecular function for BCAR1 Gene
- UniProtKB/Swiss-Prot Function:
- Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004871 | signal transducer activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 9285683 |
| GO:0017124 | SH3 domain binding | IEA | -- |
| GO:0019901 | protein kinase binding | IPI | 8070403 |
Phenotypes for BCAR1 Gene
- MGI mutant phenotypes for BCAR1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for BCAR1:
-
- Increased vaccinia virus (VACV) infection
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased cell migration
- Increased cell migration
- Decreased viability
Animal Models for BCAR1 Gene
- MGI Knock Outs for BCAR1:
-
- Bcar1 tm1Hhi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BCAR1
-
- Search ViGene Biosciences for BCAR1
CRISPR Products
-
OriGene CRISPR knockouts for BCAR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCAR1
- GenScript: Design CRISPR guide RNA sequences for BCAR1
miRNA for BCAR1 Gene
- miRTarBase miRNAs that target BCAR1
-
- hsa-mir-3978 (MIRT697045)
- hsa-mir-139-3p (MIRT697046)
- hsa-mir-6124 (MIRT697047)
- hsa-mir-3148 (MIRT697048)
- hsa-mir-509-3p (MIRT697049)
- hsa-mir-7853-5p (MIRT697050)
- hsa-mir-105-5p (MIRT697051)
- hsa-mir-580-5p (MIRT697052)
- hsa-mir-522-3p (MIRT697053)
- hsa-mir-224-3p (MIRT697054)
- hsa-mir-4694-3p (MIRT697055)
- hsa-mir-548t-3p (MIRT697056)
- hsa-mir-548ap-3p (MIRT697057)
- hsa-mir-548aa (MIRT697058)
miRNA Products
- Search ViGene Biosciences for BCAR1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for BCAR1
- Browse OriGene Inhibitory RNA Products For BCAR1
Clone Products
-
OriGene ORF clones in human for BCAR1
- RC230582
- RC230582L1
- RC230582L2
- RG230582
- RC230560
- RG209133
- RC209133L2
- RC209133L1
- RC209133
- RG230404
- RC230404L2
- RC230404L1
- RC230404
- RG230457
- RC230457L2
- RC230457L1
- RC230457
- RG230550
- RC230550L2
- RC230550L1
- RC230550
- RG230552
- RC230552L2
- RC230552L1
- RC230552
- RG230562
- RC230562L2
- RC230562L1
- RC230562
- RG230561
- RC230561L2
- RC230561L1
- RC230561
- RG230560
- RC230560L2
- RC230560L1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for BCAR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCAR1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for BCAR1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCAR1 Gene
Localization for BCAR1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BCAR1 Gene
- Cell junction, focal adhesion. Cytoplasm. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| cytoskeleton | 4 |
| nucleus | 4 |
| plasma membrane | 3 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | IDA | 9472046 |
| GO:0005737 | cytoplasm | IDA,IEA | 8070403 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | colocalizes_with plasma membrane | IDA | 21245381 |
| GO:0005925 | focal adhesion | IDA,ISS | -- |
Pathways & Interactions for BCAR1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling | ||
| 2 | Focal Adhesion |
.62
.62
|
|
| 3 | Sertoli-Sertoli Cell Junction Dynamics | ||
| 4 | Integrin Pathway |
.67
.67
|
|
| 5 | Integrin alphaIIb beta3 signaling | ||
Pathways by source for BCAR1 Gene
2 Cell Signaling Technology pathways for BCAR1 Gene
23 BioSystems pathways for BCAR1 Gene
12 Reactome pathways for BCAR1 Gene
1 PharmGKB pathway for BCAR1 Gene
6 KEGG pathways for BCAR1 Gene
6 GeneGo (Thomson Reuters) pathways for BCAR1 Gene
13 Qiagen pathways for BCAR1 Gene
Interacting Proteins for BCAR1 Gene
Selected Interacting proteins:
P56945-BCAR1_HUMAN
ENSP00000391669
for BCAR1 Gene via
IID
STRING
UniProtKB
MINT
SIGNOR curated interactions for BCAR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | TAS | 11607844 |
| GO:0007015 | actin filament organization | IDA | 16105984 |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007173 | epidermal growth factor receptor signaling pathway | ISS | -- |
Transcripts for BCAR1 Gene
mRNA/cDNA for BCAR1 Gene
- (16) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (339) Selected AceView cDNA sequences:
- (22) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for BCAR1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for BCAR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCAR1
- GenScript: Design CRISPR guide RNA sequences for BCAR1
miRNA Products
- Search ViGene Biosciences for BCAR1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for BCAR1
- Browse OriGene Inhibitory RNA Products For BCAR1
Clone Products
-
OriGene ORF clones in human for BCAR1
- RC230582
- RC230582L1
- RC230582L2
- RG230582
- RC230560
- RG209133
- RC209133L2
- RC209133L1
- RC209133
- RG230404
- RC230404L2
- RC230404L1
- RC230404
- RG230457
- RC230457L2
- RC230457L1
- RC230457
- RG230550
- RC230550L2
- RC230550L1
- RC230550
- RG230552
- RC230552L2
- RC230552L1
- RC230552
- RG230562
- RC230562L2
- RC230562L1
- RC230562
- RG230561
- RC230561L2
- RC230561L1
- RC230561
- RG230560
- RC230560L2
- RC230560L1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for BCAR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCAR1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for BCAR1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Testis (9.6), Plasma (9.5), Islet of Langerhans (9.1), Fetal Brain (7.3), Placenta (7.2), and Pancreas (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCAR1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of BCAR1 Gene:
BCAR1SOURCE GeneReport for Unigene cluster for BCAR1 Gene:
Hs.479747mRNA Expression by UniProt/SwissProt for BCAR1 Gene:
P56945-BCAR1_HUMAN
Tissue specificity:
Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.
Evidence on tissue expression from TISSUES for BCAR1 Gene
- Eye(4.9)
- Nervous system(4.9)
- Bone(4.8)
- Lung(4.7)
- Skin(4.7)
- Muscle(4.6)
- Pancreas(4.3)
- Kidney(4.1)
- Intestine(3.9)
- Blood(3.5)
- Heart(3)
- Liver(2.5)
Primer Products
-
OriGene qPCR primer pairs for BCAR1
-
OriGene qPCR primer pairs and template standards for BCAR1
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCAR1 Gene
Orthologs for BCAR1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BCAR1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | BCAR1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | BCAR1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bcar1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Bcar1 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | BCAR1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BCAR1 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bcar1 34 |
|
||
| Str.15275 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68466 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | bcar1 34 35 |
|
||
| Dr.4707 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | p130CAS 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6681 35 |
|
OneToMany |
- Species where no ortholog for BCAR1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for BCAR1 Gene
(3) SIMAP similar genes for BCAR1 Gene using alignment to 14 proteins:
Pseudogenes.org Pseudogenes for BCAR1 Gene
Variants for BCAR1 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035798 | A breast cancer sample | ||||
| rs1000000831 | -- | 75,257,991(+) | TAAAT(A/G)TACCC | intron-variant | |
| rs1000001749 | -- | 75,231,099(+) | TAATC(C/T)TTTTT | intron-variant | |
| rs1000052574 | -- | 75,255,295(+) | CTCTG(A/G)GAGCG | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000105045 | -- | 75,259,902(+) | AATAA(A/T)GCCAG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3582321 | CNV | loss | 25503493 |
| esv3582322 | CNV | loss | 25503493 |
| nsv149 | OTHER | inversion | 15895083 |
| nsv471095 | CNV | loss | 18288195 |
| nsv516504 | CNV | gain+loss | 19592680 |
| nsv523405 | CNV | loss | 19592680 |
| nsv7286 | OTHER | inversion | 18451855 |
| nsv833282 | CNV | gain+loss | 17160897 |
| nsv9459 | CNV | gain | 18304495 |
| nsv978002 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.52;
71.95% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for BCAR1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCAR1 Gene
Disorders for BCAR1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| estrogen resistance |
|
|
| differentiating neuroblastoma |
|
|
| breast cancer |
|
|
| cerebral hypoxia |
|
|
| nephronophthisis 1, juvenile |
|
Search BCAR1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for BCAR1
No data available for UniProtKB/Swiss-Prot and Genatlas for BCAR1 Gene
Publications for BCAR1 Gene
- BCAR1, a human homologue of the adapter protein p130Cas, induces anti-estrogen resistance in breast cancer cells. (PMID: 10639512) Brinkman A. … Dorssers L.C.J. (J. Natl. Cancer Inst. 2000) 2 3 4 22 64
- The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity. (PMID: 15784259) Wisniewska M. … Engh R.A. (J. Mol. Biol. 2005) 3 4 22 64
- Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. (PMID: 10587647) Eisenmann K.M. … Iida J. (Nat. Cell Biol. 1999) 3 4 22 64
- NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. (PMID: 22081014) Mace P.D. … Riedl S.J. (Nat. Struct. Mol. Biol. 2011) 3 4 64
- Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression. (PMID: 20534451) Wang Y. … Klemke R.L. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 64
Products for BCAR1 Gene
- R&D Systems Antibodies for BCAR1 (p130Cas)
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- Custom Antibody ServicesOriGene Antibodies for BCAR1
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for BCAR1
- Browse OriGene Inhibitory RNA Products For BCAR1
- OriGene qPCR primer pairs and template standards for BCAR1
- OriGene qPCR primer pairs for BCAR1
- OriGene CRISPR knockouts for BCAR1
- OriGene ORF clones in human for BCAR1
- RC230582
- RC230582L1
- RC230582L2
- RG230582
- RC230560
- RC230560L1
- RC230560L2
- RG230560
- RC230561
- RC230561L1
- RC230561L2
- RG230561
- RC230562
- RC230562L1
- RC230562L2
- RG230562
- RC230552
- RC230552L1
- RC230552L2
- RG230552
- RC230550
- RC230550L1
- RC230550L2
- RG230550
- RC230457
- RC230457L1
- RC230457L2
- RG230457
- RC230404
- RC230404L1
- RC230404L2
- RG230404
- RC209133
- RC209133L1
- RC209133L2
- RG209133
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for BCAR1
- Novus Biologicals proteins and lysates for BCAR1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for BCAR1
- Cloud-Clone Corp. Antibodies for BCAR1
- Cloud-Clone Corp. Proteins for BCAR1
- Cloud-Clone Corp Assay Kits for BCAR1
- Invitrogen Antibodies for BCAR1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for BCAR1: See all 187
- antibodies-online Kits for BCAR1: See all 17
- antibodies-online Proteins for BCAR1: See all 6
- Search antibodies-online for peptides
- GeneTex BCAR1 antibody for BCAR1
- Search GeneTex for Proteins for BCAR1
- Search ViGene Biosciences for BCAR1
- Santa Cruz Biotechnology (SCBT) Antibodies for BCAR1
- Search Santa Cruz Biotechnology (SCBT) for BCAR1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BCAR1
- Horizon Cell Lines for BCAR1
- Cyagen custom Knockout/knockin (KOKI) mouse models for BCAR1
- VectorBuilder custom plasmid, inducible vectors for BCAR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCAR1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for BCAR1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer