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BCAR1 Gene

protein-coding GIFtS: 59

GC16M073820

breast cancer anti-estrogen resistance 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CAS ^¹, ², ³, ⁵
CAS1 ^²
CASS1 ^¹, ², ³
CRKAS ^², ³, ⁵
Crkas ^¹
P130Cas ^¹, ²
p130cas ^³

Descriptions
CRK-associated substrate ^³
Cas scaffolding protein family member 1 ^², ³
Crk-associated substrate p130Cas ^²
breast cancer anti-estrogen resistance 1 ^²

External Ids
HGNC: 971¹
Entrez Gene: 9564²
UniProtKB: P56945³
Ensembl: ENSG00000050820⁷

Search outside databases for aliases for BCAR1 gene

Previous GC identifers: GC16M066192 GC16M076223 GC16M075001 GC16M075042

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BCAR1:

BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events,

including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed

17129785]).[supplied by OMIM]

UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945

Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based

signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression

confers antiestrogen resistance on breast cancer cells

Gene Wiki entry for BCAR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BCAR1 gene

Entrez Gene cytogenetic band: 16q22-q23 Ensembl cytogenetic band: 16q23.1 HGNC cytogenetic band: 16q22-q23

BCAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M073820: (about GC identifiers)

Start:	73,820,429 bp from pter
End:	73,859,452 bp from pter
Size:	39,024 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000016.8 NT_010498.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945 (See protein sequence)

Recommended Name: Breast cancer anti-estrogen resistance protein 1

Size: 870 amino acids; 93362 Da

Subunit: Forms complexes in vivo with focal adhesion kinase 1, adapter protein CRKL and LYN kinase.

Can heterodimerize with CASL. Interacts with BCAR3, NPHP1, PTK2B and SH2D3C (By similarity).

Interacts with activated CSPG4. Interacts with INPPL1/SHIP2

Subcellular location: Cell junction, focal adhesion (By similarity). Cytoplasm (By similarity).

Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine

phosphorylation (By similarity)

PDB structures from and Proteopedia :

1WYX (3D)

Post-translational modifications:

Focal adhesion kinase 1 phosphorylates the protein at the YDYVHL motif. SRC-family kinases are

recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine

phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055382.2

ENSEMBL proteins:

ENSP00000162330 ENSP00000377074 ENSP00000377072

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BCAR1)
	Human Recombinant Proteins from Abnova (BCAR1)

OriGene Purified Recombinant Human Protein: BCAR1

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IDA	9472046
GO:0005624	membrane fraction	IDA	8070403
GO:0005737	cytoplasm	IDA	8070403
GO:0005925	focal adhesion	ISS	--
GO:0030054	cell junction	IEA	--

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Antibodies for BCAR1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of BCAR1
	Sigma-Aldrich Antibody Arrays and Antibodies for BCAR1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for BCAR1 (p130cas)
	Antibodies from Abcam (BCAR1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for BCAR1

Assays for BCAR1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P56945

ProtoNet protein and cluster: P56945

1 Blocks protein family: IPB001452 SH3 domain signature

UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945

Domain: Contains a central domain (substrate domain) containing multiple potential SH2-binding

sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding

sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the

induction of pseudohyphal growth in yeast and mediates heterodimerization with CASL (By

similarity)

Domain: A serine-rich region promotes activation of the serum response element (SRE)

Domain: The SH3 domain is necessary for the localization of the protein to focal adhesions and

interacts with one proline-rich region of focal adhesion kinase 1

Similarity: Belongs to the CAS family

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BCAR1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BCAR1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014567

Applied Biosystems Silencer® siRNAs for BCAR1

Sigma-Aldrich siRNA and siRNA Panels for BCAR1

Sigma-Aldrich shRNA Panels and shRNA for BCAR1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BCAR1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014567
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014567
untagged cDNA clone in CMV expression vector: NM_014567

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014567

UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945

Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based

signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression

confers antiestrogen resistance on breast cancer cells

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Bcar1):

	cellular	embryogenesis	growth/size	lethality-prenatal/perinatal
liver/biliary system	muscle

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	TAS	8070403
GO:0005515	protein binding	IPI	9748234 10339567 10587647 11782456 14688263 16105984
GO:0017124	SH3 domain binding	IEA	--
GO:0019901	protein kinase binding	IPI	8070403 8649368 9020138 9472046 10026197 16245368
GO:0019903	protein phosphatase binding	IPI	9285683

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/10 Sigma-Aldrich "Your Favorite Gene" Pathways for BCAR1 (Your Favorite Gene powered by Ingenuity) (see all 10 )

Integrin Signaling
ERK/MAPK Signaling
Germ Cell-Sertoli Cell Junction Signaling
Actin Cytoskeleton Signaling
PTEN Signaling

GeneDecks BCAR1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for BCAR1

5/127 Interacting proteins for BCAR1 (ENSP00000162330³ P56945^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 127 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FYN	P06241¹	STRING (score=.991) EBI-702093, EBI-515315
PTPN1	P18031²	STRING (score=.999) MINT-6793484 MINT-6762444 MINT-6764626 MINT-6793467 MINT-6793403
PTPN12	Q05209²	STRING (score=.998) MINT-74926 MINT-74936 MINT-74927 MINT-74933
MMP14	P50281²	STRING (score=.745) MINT-6174781 MINT-6174763 MINT-6174753
ACTB	P60709²	STRING (score=.733) MINT-6174734

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5/15 Gene Ontology (GO) biological process terms (links to tree view) (see all 15 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	TAS	11607844
GO:0007015	actin filament organization	IDA	16105984
GO:0007155	cell adhesion	IEA	--
GO:0007173	epidermal growth factor receptor signaling pathway	ISS	--
GO:0007186	G-protein coupled receptor protein signaling pathway	NAS	10092204

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BCAR1
10/16 Novoseek chemical compound relationships for BCAR1 gene (see all 16 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	81.77	262	9748296 (7), 9648724 (6), 7541040 (6), 9575907 (5) (see all 99)
phosphotyrosine	55.88	9	9422981 (1), 10739664 (1), 9032297 (1), 15044442 (1) (see all 8)
phosphatidylinositol	45.84	9	9748296 (2), 10842093 (1), 19330798 (1), 10339567 (1) (see all 7)
proline	32.50	1	16289152 (1)
ganglioside	27.82	2	18078823 (1), 18538130 (1)
12-o-tetradecanoylphorbol 13-acetate	14.97	8	9442079 (3), 12694376 (1)
pd 98,059	14.90	1	10737896 (1)
threonine	11.40	7	11593413 (3), 9922457 (2), 9581808 (1)
okadaic acid	5.73	1	11593413 (1)
calcium	3.76	7	9648724 (3), 10093970 (1), 15841322 (1), 9575907 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BCAR1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BCAR1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014567

Sigma-Aldrich siRNA and siRNA Panels for BCAR1

Sigma-Aldrich shRNA Panels and shRNA for BCAR1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014567

REFSEQ mRNAs for BCAR1 gene:

NM_014567.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014567

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014567
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014567
                                 untagged cDNA clone in CMV expression vector: NM_014567

Additional cDNA sequence:

AB040024.1 AF218451.1 AJ242987.2 AK026121.1 AK027608.1 AK074958.1 AK124526.1 AK124815.1

AK124844.1 AK125719.1 AK127004.1 AK293808.1 AK294513.1 AK295809.1 AK302617.1 AK314722.1

AY545071.1 BC014402.1 BC062556.1 CR622696.1

19 DOTS entries:

DT.100652053 DT.102840383 DT.454557 DT.95122178 DT.101984968 DT.100777466 DT.86856714 DT.101984970

DT.95079485 DT.95322529 DT.100708641 DT.120680549 DT.120680602 DT.120680562 DT.95090466 DT.120680548

DT.120680552 DT.120680558 DT.120680563

24/339 AceView cDNA sequences (see all 339 ):

AA364512 BQ688682 CF132221 BG831538 BU542520 BQ447600 BU838220 BU786754

BF345455 BG387070 CA488735 BG775027 NM_014567 AI055829 BG775766 BM826658

BQ771939 CF529831 CF529919 CA418835 BM798009 BU541498 BU157529 AI369230

highest scoring ESTs for BCAR1:

AB040024 AF218451 AJ242987 AK027608 AK124526 AK124815 AL040801 AW001536 BG912589 BM545006

Unigene Cluster for BCAR1:

Breast cancer anti-estrogen resistance 1

Hs.479747 [show with all ESTs]

Unigene Representative Sequence: AK124526

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000162330 ENST00000393422 ENST00000393420

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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BCAR1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BCAR1

¹ / ² / ³

3 probe-sets matching BCAR1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
65885_at²^{, 3}	U95-C	1	1.00	1.00	1.00	1.00	AW001536	0.80	1.00	0.91	1
223116_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF218451	0.80	1.00	0.91	1
223116_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks BCAR1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CACCACGGGC

SOURCE GeneReport for Unigene cluster: Hs.479747
UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945
Tissue specificity: Widely expressed with an abundant expression in the testis. Low level of
expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been
detected in a B-cell line

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BCAR1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BCAR1¹	--	breast cancer anti-estrogen resistance 1	88.34(n) 92.82(a)	479648 XM_847859.1 XP_852952.1
chimpanzee (Pan troglodytes)	BCAR1¹	--	breast cancer anti-estrogen resistance 1	99.54(n) 99.65(a)	454246 XM_001140164.1 XP_001140164.1
cow (Bos taurus)	BCAR1¹	--	breast cancer anti-estrogen resistance 1	86.86(n) 89.55(a)	527550 XM_605943.3 XP_605943.3
rat (Rattus norvegicus)	Bcar1¹	--	breast cancer anti-estrogen resistance 1	85.8(n) 91.69(a)	25414 NM_012931.1 NP_037063.1
mouse (Mus musculus)	Bcar1^{1, 5}	8⁵	breast cancer anti-estrogen resistance 1^{1, 5}	85.64(n)¹ 91.22(a)¹	12927¹ NM_009954.2¹ NP_034084.2¹ AA050786⁵ AI385681⁵ (see all 32)

About this table Species with no ortholog for BCAR1

ENSEMBL Gene Tree for BCAR1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for BCAR1 gene

NEDD9² CASS4² EFS²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/147 NCBI SNPs in BCAR1 are shown (see all 147 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 82)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs5842^1,2	A,C,F,H,O	73820525(+)	`CCTGGA/TAAGGC`	1	--	ut3¹ ese³		10		MN EU EA WA NA	1006
	rs16957552^1,2	C,F,H	73826625(+)	`GACCAT/CGTGCC`	1	R/H	mis¹ ese³		7		NA EU EA WA	548
--	rs1035539^1,2	A,C,F	73834276(+)	`GCCGGA/GGCCAG`	1	P/S	mis¹		2		MN EA	1652
--	rs11640206^1,2	A,C	73820430(+)	`CAGCTA/GCTCTT`	1	--	ut3¹		0	--	--	--	--
	rs16957558^1,2	F,H	73826826(+)	`GGCTAC/AGCCAG`	1	L/R	mis¹ ese³		7		NA EU EA WA	562
	rs5005337^1,2	H	73834464(+)	`CATTGT/ACATAG`	1	V/D	mis¹		3		EA WA	250
	rs3743613^1,2	A,C,F,H	73827035(+)	`TCTGCT/CGGGGC`	1	P/P	syn¹ ese³		8		EA NA EU WA	2052
--	rs3169330^1,2	C,F,H,O	73826768(-)	`GCCGCC/TGTCCA`	1	A/A	syn¹ ese³		8		MN EU EA WA NA	716
	rs7190458^1,2	C,F,H	73821162(+)	`GCGCTG/AAGGAT`	1	L/L	syn¹ ese³		11		EU EA WA NA	980
	rs16957559^1,2	F,H	73826879(+)	`GCAACG/AGTGGC`	1	T/T	syn¹ ese³		7		NA EU EA WA	556

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HapMap Linkage Disequilibrium images for BCAR1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602941

10/13 Novoseek disease relationships for BCAR1 gene (see all 13 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
nphp1	77.23	1	10739664 (1)
cystic kidney disease	54.32	1	10739664 (1)
breast cancer	32.64	28	15277346 (5), 15448007 (4), 10639512 (3), 10896938 (2) (see all 13)
tumors	28.03	11	15448007 (3), 9927060 (1), 18842495 (1), 18845837 (1) (see all 9)
colon cancer	19.59	2	14667936 (1), 18392556 (1)
metastasis	18.72	5	18842495 (2), 18845837 (1), 18256281 (1)
melanoma	5.84	6	18078823 (2), 10587647 (2), 17185516 (1), 18538130 (1)
cancer	4.74	1	18256281 (1)
inflammation	0.00	1	12219172 (1)
hypertrophy	0.00	1	11514617 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/312 PubMed articles for BCAR1 gene (see all 312 ):

BCAR1, a human homologue of the adapter protein p130Cas, induces anti-estrogen resistance in breast cancer cells. (PubMed id 10639512)^{1, 2, 3, 4} Brinkman A.... Dorssers L.C.J. (2000)
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. (PubMed id 10587647)^{1, 3, 4} Eisenmann K.M.... Iida J. (1999)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC). (PubMed id 16212419)^{3, 4} Amanchy R.... Pandey A. (2005)
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)^{3, 4} Zhang Y.... White F.M. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading. (PubMed id 11158326)^{3, 4} Prasad N.... Decker S.J. (2001)
Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site. (PubMed id 8413311)^{2, 3} Dorssers L.C....Kok E.M. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9564	HGNC: 971	AceView: BCAR1	Ensembl:ENSG00000050820	euGenes: HUgn9564
ECgene: BCAR1	H-InvDB: BCAR1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for BCAR1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for BCAR1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BCAR1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BCAR1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BCAR1		Antibodies for BCAR1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BCAR1		Browse small molecules at Sigma-Aldrich
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Antibodies & Assays for BCAR1 (p130cas)

	Recombinant Proteins (BCAR1)
	Antibodies (BCAR1)

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Antibodies for BCAR1

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BCAR1 Gene at Home site.
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BCAR1 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for BCAR1

Summaries
for BCAR1

Genomic Location
for BCAR1

Proteins
for BCAR1

Protein Domains/
Families
for BCAR1

Gene Function
for BCAR1

Pathways & Interactions
for BCAR1

Drugs & Compounds
for BCAR1

Transcripts
for BCAR1

Expression
for BCAR1

Orthologs
for BCAR1

Paralogs
for BCAR1

SNPs/Variants
for BCAR1

Disorders & Mutations
for BCAR1

Medical News
for BCAR1

Publications
for BCAR1

Search for BCAR1

Genome Databases showing BCAR1

Other Databases showing BCAR1

Specialized Databases showing BCAR1

Licensable Technologies
for BCAR1

Services
for BCAR1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BCAR1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor BCAR1

Summariesfor BCAR1

Genomic Locationfor BCAR1

Proteinsfor BCAR1

Protein Domains/Familiesfor BCAR1

Gene Functionfor BCAR1

Pathways & Interactionsfor BCAR1

Drugs & Compoundsfor BCAR1

Transcriptsfor BCAR1

Expression for BCAR1

Orthologsfor BCAR1

Paralogsfor BCAR1

SNPs/Variantsfor BCAR1

Disorders & Mutationsfor BCAR1

Medical Newsfor BCAR1

Publicationsfor BCAR1

Search for BCAR1

Genome Databases showing BCAR1

Other Databases showing BCAR1

Specialized Databases showing BCAR1

Licensable Technologiesfor BCAR1

Servicesfor BCAR1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BCAR1

Summaries
for BCAR1

Genomic Location
for BCAR1

Proteins
for BCAR1

Protein Domains/
Families
for BCAR1

Gene Function
for BCAR1

Pathways & Interactions
for BCAR1

Drugs & Compounds
for BCAR1

Transcripts
for BCAR1

Expression
for BCAR1

Orthologs
for BCAR1

Paralogs
for BCAR1

SNPs/Variants
for BCAR1

Disorders & Mutations
for BCAR1

Medical News
for BCAR1

Publications
for BCAR1

Licensable Technologies
for BCAR1

Services
for BCAR1