BCAR1 Gene

Aliases
for BCAR1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC16M066192 GC16M076223 GC16M075001 GC16M075042 GC16M073820 GC16M061013

Summaries
for BCAR1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for BCAR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000016.9  NT_010498.16  NC_018927.2  

SwitchGear Promoter luciferase reporter plasmids (see all 10): BCAR1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCAR1

BCAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M075262:  view genomic region     (about GC identifiers)

Proteins
for BCAR1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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2 PDB 3D structures from and Proteopedia for BCAR1:

1WYX (3D)        3T6G (3D)    

Explore the universe of human proteins at neXtProt for BCAR1: NX_P56945

Explore proteomics data for BCAR1 at MOPED

Post-translational modifications: 

BCAR1 Human Recombinant Protein Products:

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	antibodies-online proteins for BCAR1 (4 products)
	antibodies-online peptides for BCAR1

BCAR1 Antibody Products:

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	ThermoFisher Antibody for BCAR1
	antibodies-online antibodies for BCAR1 (170 products)

BCAR1 Assay Products:

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	Cloud-Clone Corp. ELISAs for BCAR1 Cloud-Clone Corp. CLIAs for BCAR1
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	antibodies-online kits for BCAR1 (16 products)

Domains /
Families
for BCAR1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P56945

Find genes that share domains with BCAR1           About GenesLikeMe

Function
for BCAR1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 4 molecular function terms:    About this table

(inferred from 2 alleles) (MGI details for Bcar1)

genOway: Develop your customized and physiologically relevant rodent model for BCAR1

miRNA Products:		Block miRNA regulation of human, mouse, rat BCAR1 using miScript Target Protectors
		5 qRT-PCR Assays for microRNAs that regulate BCAR1:
		hsa-miR-148b* hsa-miR-3168 hsa-miR-3148 hsa-miR-105 hsa-miR-509-3p
		SwitchGear 3'UTR luciferase reporter plasmid: BCAR1 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat BCAR1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for BCAR1

Clone Products:		OriGene clones in human, mouse for BCAR1 (see all 41) OriGene ORF clones in mouse, rat for BCAR1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 9): BCAR1 (NM_001170714)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAR1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAR1

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		Browse ESI BIO Cell Lines and PureStem Progenitors for BCAR1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR1

Localization
for BCAR1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	4
plasma membrane	3
cytoskeleton	2
nucleus	2
mitochondrion	1

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Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

Pathways & Interactions
for BCAR1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for BCAR1 About   (see all 44)   See pathways by source

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	SuperPath	Contained pathways About
1	Focal adhesion	Focal Adhesion 0.65 Integrin-mediated cell adhesion 0.38 Focal adhesion 0.65
2	Regulation of actin cytoskeleton	Regulation of Actin Cytoskeleton 0.57 Regulation of actin cytoskeleton 0.57
3	Chemokine Signaling	Chemokine Signaling 0.33 Chemokine signaling pathway 0.33
4	Integrin alphaIIb beta3 signaling	Integrin alphaIIb beta3 signaling 0.73 p130Cas linkage to MAPK signaling for integrins 0.00 Platelet Aggregation (Plug Formation) 0.73
5	Integrin Pathway	FAK1 Signaling 0.67 Transendothelial Migration of Leukocytes 0.38 Integrin Pathway 0.67

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BCAR1

	Chemokine Signaling
	MAPK Signaling
	Sertoli-Sertoli Cell Junction Dynamics
	Paxillin Interactions
	PTEN Pathway

2 Cell Signaling Technology (CST) Pathways for BCAR1

	Tyrosine Kinases / Adaptors
	Adhesion

Selected GeneGo (Thomson Reuters) Pathways for BCAR1

	Cell adhesion PLAU signaling
	Cell adhesion Integrin-mediated cell adhesion and migration
	Signal transduction PTEN pathway
	Cytoskeleton remodeling FAK signaling
	Development Angiotensin signaling via PYK2

Selected BioSystems Pathways for BCAR1

	Focal Adhesion
	Integrin-mediated cell adhesion
	EGFR1 Signaling Pathway
	Regulation of Actin Cytoskeleton
	B Cell Receptor Signaling Pathway

2 Reactome Pathways for BCAR1

	Downstream signal transduction
	p130Cas linkage to MAPK signaling for integrins

1 PharmGKB Pathway for BCAR1

Celecoxib Pathway, Pharmacodynamics

Selected Kegg Pathways  (Kegg details for BCAR1)

	Rap1 signaling pathway
	Chemokine signaling pathway
	Focal adhesion
	Leukocyte transendothelial migration
	Regulation of actin cytoskeleton

Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

Drugs & Compounds
for BCAR1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for BCAR1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for BCAR1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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BCAR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CACCACGGGC

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Brain (Nervous System)    fully expand to see all 3 entries
Cerebellum
Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast
Ovary (Reproductive System)
Oviduct

Primer Products:		OriGene qPCR primer pairs and template standards for BCAR1 OriGene qSTAR qPCR primer pairs in human, mouse for BCAR1
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCAR1
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		QuantiFast Probe-based Assays in human, mouse, rat BCAR1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR1

Orthologs
for BCAR1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for BCAR1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for BCAR1 gene

NEDD9²  CASS4²  EFS²  

3 SIMAP similar genes for BCAR1 using alignment to 14 protein entries:     BCAR1_HUMAN (see all proteins):

SH3GL2    ARHGEF7    NEDD9

Find genes that share paralogs with BCAR1           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for BCAR1
PGOHUM00000246616 PGOHUM00000246633

Genomic Variants
for BCAR1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for BCAR1 (see all 1205)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
VAR_0357984		A breast cancer sample4	--	see VAR_035798	2	S T	mis4		0	--	--	--	--
rs1404612831,2		--	75262468(+)	TTCCGC/GAGGCT	9	--	int1		0	--	--	--	--
rs1444238081,2		--	75262485(+)	AGATTA/CTTTTA	9	--	int1		0	--	--	--	--
rs1180395591,2	F	--	75262626(+)	GGCAGC/TTCCCT	9	--	int1		1		NA	120
rs772763551,2	C	--	75262638(+)	GGGTTG/ACAGGG	9	--	int1		4		NA WA EA	360
rs1169907731,2	C,F	--	75262639(+)	GGTTGC/AAGGGG	9	--	int1		1		NA	120
rs1807859231,2		--	75262662(+)	TGTGCA/TTTCTG	9	--	int1		0	--	--	--	--
rs1173885701,2	F	--	75262673(+)	GGCCCC/TAGACC	9	--	int1		1		NA	120
rs1862056741,2		--	75262765(+)	CCCCGA/CCTCCA	9	--	int1		0	--	--	--	--
rs1911765771,2		--	75262868(+)	CCCGGG/TTGCCT	9	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for BCAR1 (75262928 - 75301951 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for BCAR1:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv471095	CNV	Loss	18288195
nsv523405	CNV	Loss	19592680
dgv2912n71	CNV	Loss	21882294
nsv906911	CNV	Loss	21882294
nsv906913	CNV	Loss	21882294
nsv9459	CNV	Gain	18304495
nsv833282	CNV	Gain+Loss	17160897
nsv516504	CNV	Gain+Loss	19592680
nsv7286	OTHER	Inversion	18451855
nsv149	OTHER	Inversion	15895083

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing BCAR1

DNA2.0 Custom Variant and Variant Library Synthesis for BCAR1

Disorders / Diseases
for BCAR1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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2 diseases for BCAR1

Selected Novoseek inferred disease relationships for BCAR1 gene (see all 13)    About this table

Publications
for BCAR1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. BCAR1, a human homologue of the adapter protein p130Cas, induces anti-estrogen resistance in breast cancer cells. (PubMed id 10639512)^{1, 2, 3, 9} Brinkman A.... Dorssers L.C.J. (J. Natl. Cancer Inst. 2000)
2. The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity. (PubMed id 15784259)^{1, 2, 9} Wisniewska M.... Engh R.A. (J. Mol. Biol. 2005)
3. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. (PubMed id 10587647)^{1, 2, 9} Eisenmann K.M.... Iida J. (Nat. Cell Biol. 1999)
4. Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. (PubMed id 19086031)^{1, 2, 9} Rufanova V.A.... Sorokin A. (J. Cell. Physiol. 2009)
5. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. (PubMed id 22081014)^{1, 2} Mace P.D.... Riedl S.J. (Nat. Struct. Mol. Biol. 2011)
6. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PubMed id 19844255)^{1, 4} Dastani Z....Genest J. (Eur. J. Hum. Genet. 2010)
7. Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. (PubMed id 17038317)^{1, 2} Modzelewska K.... Keely P.J. (J. Biol. Chem. 2006)
8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
9. SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading. (PubMed id 11158326)^{1, 2} Prasad N.... Decker S.J. (Mol. Cell. Biol. 2001)
10. Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site. (PubMed id 8413311)^{1, 3} Dorssers L.C....Kok E.M. (Mol. Endocrinol. 1993)

External Searches for BCAR1 gene

Genome Databases showing BCAR1 gene

Other Databases showing BCAR1 gene

Specialized Databases showing BCAR1 gene

Products
for BCAR1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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