Aliases for BCAR1 Gene
External Ids for BCAR1 Gene
Previous GeneCards Identifiers for BCAR1 Gene
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]
GeneCards Summary for BCAR1 Gene
BCAR1 (Breast Cancer Anti-Estrogen Resistance 1) is a Protein Coding gene. Diseases associated with BCAR1 include differentiating neuroblastoma and breast cancer. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein kinase binding and SH3 domain binding. An important paralog of this gene is NEDD9.
UniProtKB/Swiss-Prot for BCAR1 Gene
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.