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BCAR1 Gene

protein-coding   GIFtS: 63
GCID: GC16M075262

Breast Cancer Anti-Estrogen Resistance 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Breast Cancer Anti-Estrogen Resistance 11 2     CAS12
Cas Scaffolding Protein Family Member 11 2 3     P130Cas2
CAS2 3 5     Breast Cancer Anti-Estrogen Resistance Protein 12
CRKAS2 3 5     Crk-Associated Substrate P130Cas2
CRK-Associated Substrate1 3     p130cas3
CASS12 3     

External Ids:    HGNC: 9711   Entrez Gene: 95642   Ensembl: ENSG000000508207   OMIM: 6029415   UniProtKB: P569453   

Export aliases for BCAR1 gene to outside databases

Previous GC identifers: GC16M066192 GC16M076223 GC16M075001 GC16M075042 GC16M073820 GC16M061013


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BCAR1 Gene:
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including
migration, survival, transformation, and invasion (Sawada et al., 2006 (PubMed 17129785)).(supplied by OMIM, May
2009)

GeneCards Summary for BCAR1 Gene:
BCAR1 (breast cancer anti-estrogen resistance 1) is a protein-coding gene. Diseases associated with BCAR1 include estrogen resistance, and cystic kidney. GO annotations related to this gene include SH3 domain binding and protein kinase binding. An important paralog of this gene is NEDD9.

UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945
Function: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to
cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on
breast cancer cells

Gene Wiki entry for BCAR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BCAR1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   ATF-2   E2F-2   LCR-F1   E2F-1   E2F   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): BCAR1 promoter sequence
   Search Chromatin IP Primers for BCAR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCAR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q22-q23

BCAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCAR1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M075262:  view genomic region     (about GC identifiers)

Start:
75,262,928 bp from pter      End:
75,301,951 bp from pter
Size:
39,024 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945 (See protein sequence)
Recommended Name: Breast cancer anti-estrogen resistance protein 1  
Size: 870 amino acids; 93372 Da
Subunit: Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase. Can heterodimerize with
NEDD9. Interacts with BCAR3, the interaction regulates adhesion-dependent serine phosphorylation. Interacts with
NPHP1 and SH2D3C. Interacts with activated CSPG4. Interacts with BMX, INPPL1/SHIP2 and PEAK1. Part of a
collagen-stimulated complex involved in cell migration made of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with
TNK2 via SH3 domains. Interacts with PTK2B/PYK2
2 PDB 3D structures from and Proteopedia for BCAR1:
1WYX (3D)        3T6G (3D)    
Secondary accessions: B3KWD7 B4DEV4 B4DGB5 B4DIW5 B7Z7X7 E9PCL5 E9PCV2 F5GXA2 F5GXV6 F5H7Z0
F8WA69 Q6QEF7
Alternative splicing: 8 isoforms:  P56945-1   P56945-2   P56945-3   P56945-4   P56945-5   P56945-6   P56945-7   P56945-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BCAR1: NX_P56945

Explore proteomics data for BCAR1 at MOPED

Post-translational modifications: 

  • PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC
    family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine
    residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular
    matrix1
  • Dephosphorylated by PTPN14 at Tyr-1281
  • Ubiquitination2 at Lys702
  • Modification sites at PhosphoSitePlus

  • See BCAR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001164185.1  NP_001164186.1  NP_001164187.1  NP_001164188.1  NP_001164189.1  NP_001164190.1  NP_001164191.1  NP_001164192.1  
    NP_055382.2  

    ENSEMBL proteins: 
     ENSP00000162330   ENSP00000455166   ENSP00000377074   ENSP00000440370   ENSP00000443841  
     ENSP00000391669   ENSP00000440415   ENSP00000392708   ENSP00000377072   ENSP00000454702  
     ENSP00000456625   ENSP00000455810   ENSP00000456929   ENSP00000458088   ENSP00000457457  
     ENSP00000457097   ENSP00000457231   ENSP00000442161  
    Reactome Protein details: P56945

    BCAR1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BCAR1
    OriGene Protein Over-expression Lysate for BCAR1
    OriGene MassSpec for BCAR1
    OriGene Custom Protein Services for BCAR1
    GenScript Custom Purified and Recombinant Proteins Services for BCAR1
    Novus Biologicals BCAR1 Proteins
    Novus Biologicals BCAR1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BCAR1

    BCAR1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BCAR1
    R&D Systems Antibodies for BCAR1 (p130Cas)
    Cell Signaling Technology (CST) Antibodies for BCAR1  (P130Cas)
    OriGene Antibodies for BCAR1
    OriGene Custom Antibody Services for BCAR1
    Novus Biologicals BCAR1 Antibodies
    Abcam antibodies for BCAR1
    Cloud-Clone Corp. Antibodies for BCAR1
    ThermoFisher Antibody for BCAR1
    LSBio Antibodies in human, mouse, rat for BCAR1

    BCAR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BCAR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BCAR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BCAR1
    Cloud-Clone Corp. CLIAs for BCAR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CASS: Cas scaffolding proteins

    5 InterPro protein domains:
     IPR014928 Serine_rich
     IPR001452 SH3_domain
     IPR028848 BCAR1
     IPR013315 Spectrin_alpha_SH3
     IPR021901 CAS_DUF3513

    Graphical View of Domain Structure for InterPro Entry P56945

    ProtoNet protein and cluster: P56945

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945
    Domain: Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a
    C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK,
    NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast
    and mediates heterodimerization with NEDD9 (By similarity)
    Domain: A serine-rich region promotes activation of the serum response element (SRE)
    Domain: The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one
    proline-rich region of PTK2/FAK11
    Similarity: Belongs to the CAS family
    Similarity: Contains 1 SH3 domain


    BCAR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCAR1_HUMAN, P56945
    Function: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to
    cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on
    breast cancer cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI10339567
    GO:0017124SH3 domain binding IEA--
    GO:0019901protein kinase binding IPI10026197
         
    BCAR1 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bcar1):
     cardiovascular system  cellular  embryogenesis  growth/size/body  liver/biliary system 
     mortality/aging  muscle 

    BCAR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bcar1tm1Hhi for BCAR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCAR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BCAR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCAR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCAR1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat BCAR1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate BCAR1:
    hsa-miR-148b* hsa-miR-3168 hsa-miR-3148 hsa-miR-105 hsa-miR-509-3p
    SwitchGear 3'UTR luciferase reporter plasmidBCAR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BCAR1
    Predesigned siRNA for gene silencing in human, mouse, rat BCAR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BCAR1

    Clone
    Products:
         
    OriGene clones in human, mouse for BCAR1 (see all 41)
    OriGene ORF clones in mouse, rat for BCAR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 9): BCAR1 (NM_001170714)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAR1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BCAR1
    Browse ESI BIO Cell Lines and PureStem Progenitors for BCAR1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BCAR1_HUMAN, P56945: Cell junction, focal adhesion. Cytoplasm. Note=Unphosphorylated form localizes in the
    cytoplasm and can move to the membrane upon tyrosine phosphorylation (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane3
    cytoskeleton2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA9472046
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886colocalizes with plasma membrane IDA--

    BCAR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BCAR1 About   (see all 44)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    4Integrin alphaIIb beta3 signaling
    Integrin alphaIIb beta3 signaling0.73
    p130Cas linkage to MAPK signaling for integrins0.00
    Platelet Aggregation (Plug Formation)0.73
    5Integrin Pathway
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    Integrin Pathway0.67

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BCAR1 (see all 13)
        Chemokine Signaling
    MAPK Signaling
    Sertoli-Sertoli Cell Junction Dynamics
    Paxillin Interactions
    PTEN Pathway

    2 Cell Signaling Technology (CST) Pathways for BCAR1
        Tyrosine Kinases / Adaptors
    Adhesion

    Selected GeneGo (Thomson Reuters) Pathways for BCAR1 (see all 6)
        Cell adhesion PLAU signaling
    Cell adhesion Integrin-mediated cell adhesion and migration
    Signal transduction PTEN pathway
    Cytoskeleton remodeling FAK signaling
    Development Angiotensin signaling via PYK2

    Selected BioSystems Pathways for BCAR1 (see all 23)
        Focal Adhesion
    Integrin-mediated cell adhesion
    EGFR1 Signaling Pathway
    Regulation of Actin Cytoskeleton
    B Cell Receptor Signaling Pathway

    2 Reactome Pathways for BCAR1
        Downstream signal transduction
    p130Cas linkage to MAPK signaling for integrins

    1 PharmGKB Pathway for BCAR1
        Celecoxib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for BCAR1) (see all 6):
        Rap1 signaling pathway
    Chemokine signaling pathway
    Focal adhesion
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton


    BCAR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BCAR1: 
              Estrogen Receptor Signaling in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BCAR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BCAR1 (P569451, 2, 3 ENSP000001623304) via UniProtKB, MINT, STRING, and/or I2D (see all 173)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461081, 2, 3, ENSP000003005744EBI-702093,EBI-886 MINT-6763936 MINT-7104340 MINT-7104448 I2D: score=7 STRING: ENSP00000300574
    CRKLP461092, 3, ENSP000003463004MINT-8432380 I2D: score=2 STRING: ENSP00000346300
    ACTBP607092, 3, ENSP000003499604MINT-6174734 I2D: score=1 STRING: ENSP00000349960
    TNS3Q68CZ21, 3, ENSP000003121434EBI-702093,EBI-1220488 I2D: score=1 STRING: ENSP00000312143
    SFNP319472, 3MINT-3974941 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth TAS11607844
    GO:0007015actin filament organization IDA16105984
    GO:0007155cell adhesion IEA--
    GO:0007173epidermal growth factor receptor signaling pathway ISS--
    GO:0007186G-protein coupled receptor signaling pathway NAS10092204

    BCAR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BCAR1

    Selected Novoseek inferred chemical compound relationships for BCAR1 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 81.8 270 9748296 (7), 9648724 (6), 7541040 (6), 9575907 (5) (see all 99)
    cytochalasin d 65 8 7541040 (2), 7545676 (1), 9748296 (1), 12190987 (1) (see all 5)
    phosphotyrosine 57 10 9422981 (1), 10739664 (1), 9032297 (1), 15044442 (1) (see all 9)
    herbimycin a 47.8 6 9442079 (1)
    phosphatidylinositol 44.3 9 9748296 (2), 10842093 (1), 19330798 (1), 10339567 (1) (see all 7)
    k252a 34.4 2 10527630 (2)
    proline 30.8 1 16289152 (1)
    ganglioside 26.3 2 18078823 (1), 18538130 (1)
    tamoxifen 26.3 13 16849545 (5), 19330798 (3), 10896938 (2), 15277346 (1) (see all 5)
    calyculin a 24.9 5 9581808 (3), 11382927 (2)



    BCAR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BCAR1 gene (9 alternative transcripts): 
    NM_001170714.1  NM_001170715.1  NM_001170716.1  NM_001170717.1  NM_001170718.1  NM_001170719.1  NM_001170720.1  NM_001170721.1  
    NM_014567.3  

    Unigene Cluster for BCAR1:

    Breast cancer anti-estrogen resistance 1
    Hs.479747  [show with all ESTs]
    Unigene Representative Sequence: AK124526
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000162330(uc010vna.2 uc010cgu.3 uc002fdv.3 uc010vnd.2)
    ENST00000562556 ENST00000563038(uc002fdt.3) ENST00000566982(uc002fdu.3)
    ENST00000393422(uc002fdx.3) ENST00000535626(uc010vnc.2) ENST00000538440(uc002fdw.3)
    ENST00000418647(uc010vnb.2) ENST00000542031 ENST00000420641 ENST00000393420
    ENST00000569340 ENST00000564170 ENST00000568864 ENST00000564028 ENST00000566465
    ENST00000569006 ENST00000561970
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate BCAR1:
    hsa-miR-148b* hsa-miR-3168 hsa-miR-3148 hsa-miR-105 hsa-miR-509-3p
    SwitchGear 3'UTR luciferase reporter plasmidBCAR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BCAR1
    Clone
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    OriGene ORF clones in mouse, rat for BCAR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 9): BCAR1 (NM_001170714)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAR1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BCAR1
    OriGene qSTAR qPCR primer pairs in human, mouse for BCAR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCAR1
      QuantiTect SYBR Green Assays in human, mouse, rat BCAR1
      QuantiFast Probe-based Assays in human, mouse, rat BCAR1

    Additional mRNA sequence: 

    AB040024.1 AF218451.1 AJ242987.2 AK026121.1 AK027608.1 AK074958.1 AK124526.1 AK124815.1 
    AK124844.1 AK125719.1 AK293808.1 AK294513.1 AK295809.1 AK302617.1 AK314722.1 AY545071.1 
    BC014402.1 BC062556.1 

    20 DOTS entries:

    DT.100652053  DT.454557  DT.102840383  DT.95122178  DT.101984968  DT.100777466  DT.101984970  DT.86856714 
    DT.95079485  DT.207445  DT.100708641  DT.120680549  DT.120680602  DT.120680562  DT.95322529  DT.120680548 
    DT.120680552  DT.120680558  DT.120680563  DT.95090466 

    Selected AceView cDNA sequences (see all 339):

    AI493518 BU541175 CB853295 AI077504 T35098 CF529919 AI983805 CF132221 
    BQ678580 BU538302 BG775027 BQ688682 BU157529 BM789120 BU542520 BM981125 
    AW166472 BM720377 BU838220 BM680418 BM468717 AI369230 BM700048 BF345455 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BCAR1 expression in normal human tissues (normalized intensities)      BCAR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCACGGGC
    BCAR1 Expression
    About this image


    BCAR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    BCAR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCAR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479747

    UniProtKB/Swiss-Prot: BCAR1_HUMAN, P56945
    Tissue specificity: Widely expressed with an abundant expression in the testis. Low level of expression seen in
    the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BCAR1: 
              Estrogen Receptor Signaling in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BCAR1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcar11 , 5 breast cancer anti-estrogen resistance 11, 5 85.22(n)1
    90.18(a)1
      8 (57.98 cM)5
    129271  NM_009954.31  NP_034084.21 
     1117104855 
    chicken
    (Gallus gallus)
    Aves BCAR11 breast cancer anti-estrogen resistance 1 72.39(n)
    68.22(a)
      415691  XM_414057.4  XP_414057.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684662 hypothetical protein MGC68466 74.29(n)    BC060334.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.47072 Transcribed sequence with weak similarity to protein more 79.62(n)    AA495304.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p130CAS6
    p130CAS
    27(a)
    1 → many
    3L(152884-174517)


    ENSEMBL Gene Tree for BCAR1 (if available)
    TreeFam Gene Tree for BCAR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BCAR1 gene
    NEDD92  CASS42  EFS2  
    3 SIMAP similar genes for BCAR1 using alignment to 14 protein entries:     BCAR1_HUMAN (see all proteins):
    SH3GL2    ARHGEF7    NEDD9

    BCAR1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for BCAR1
    PGOHUM00000246616 PGOHUM00000246633


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BCAR1 (see all 1205)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357984
    A breast cancer sample4--see VAR_0357982 S T mis40--------
    rs1404612831,2
    --75262468(+) TTCCGC/GAGGCT 9 -- int10--------
    rs1444238081,2
    --75262485(+) AGATTA/CTTTTA 9 -- int10--------
    rs1180395591,2
    F--75262626(+) GGCAGC/TTCCCT 9 -- int11Minor allele frequency- T:0.03NA 120
    rs772763551,2
    C--75262638(+) GGGTTG/ACAGGG 9 -- int14Minor allele frequency- A:0.10NA WA EA 360
    rs1169907731,2
    C,F--75262639(+) GGTTGC/AAGGGG 9 -- int11Minor allele frequency- A:0.02NA 120
    rs1807859231,2
    --75262662(+) TGTGCA/TTTCTG 9 -- int10--------
    rs1173885701,2
    F--75262673(+) GGCCCC/TAGACC 9 -- int11Minor allele frequency- T:0.01NA 120
    rs1862056741,2
    --75262765(+) CCCCGA/CCTCCA 9 -- int10--------
    rs1911765771,2
    --75262868(+) CCCGGG/TTGCCT 9 -- int10--------

    HapMap Linkage Disequilibrium report for BCAR1 (75262928 - 75301951 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for BCAR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471095CNV Loss18288195
    nsv523405CNV Loss19592680
    dgv2912n71CNV Loss21882294
    nsv906911CNV Loss21882294
    nsv906913CNV Loss21882294
    nsv9459CNV Gain18304495
    nsv833282CNV Gain+Loss17160897
    nsv516504CNV Gain+Loss19592680
    nsv7286OTHER Inversion18451855
    nsv149OTHER Inversion15895083

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602941    OMIM disorders: --

    Selected diseases for BCAR1 (see all 30):    About MalaCards
    estrogen resistance    cystic kidney    differentiating neuroblastoma    breast cancer
    stomach cancer    wiskott-aldrich syndrome    neuroblastoma    kidney disease
    oral cancer    kaposi's sarcoma    lung adenocarcinoma    peritonitis
    astrocytoma    coronary artery disease    melanoma    breast and colorectal cancer
    endotheliitis    sarcoma    crohn's disease    adenocarcinoma


    BCAR1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for BCAR1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nphp1 76.2 1 10739664 (1)
    cystic kidney disease 52.9 1 10739664 (1)
    breast cancer 32.9 39 15277346 (5), 15448007 (4), 10639512 (3), 19940159 (2) (see all 15)
    tumors 30.3 17 15448007 (3), 9927060 (1), 18842495 (1), 18845837 (1) (see all 12)
    metastasis 29.9 7 18842495 (2), 18845837 (1), 19909363 (1), 19937461 (1) (see all 5)
    colon cancer 21.6 2 14667936 (1), 18392556 (1)
    cancer 19 3 19909363 (1), 19937461 (1), 18256281 (1)
    melanoma 8.54 7 18078823 (2), 10587647 (2), 17185516 (1), 19937461 (1) (see all 5)
    breast carcinoma 0 3 15020686 (1), 11605729 (1), 19103205 (1)
    inflammation 0 1 12219172 (1)

    Genetic Association Database (GAD): BCAR1
    Human Genome Epidemiology (HuGE) Navigator: BCAR1 (1 document)

    Export disorders for BCAR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BCAR1 gene, integrated from 10 sources (see all 402):
    (articles sorted by number of sources associating them with BCAR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BCAR1, a human homologue of the adapter protein p130Cas, induces anti-estrogen resistance in breast cancer cells. (PubMed id 10639512)1, 2, 3, 9 Brinkman A.... Dorssers L.C.J. (J. Natl. Cancer Inst. 2000)
    2. The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity. (PubMed id 15784259)1, 2, 9 Wisniewska M.... Engh R.A. (J. Mol. Biol. 2005)
    3. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. (PubMed id 10587647)1, 2, 9 Eisenmann K.M.... Iida J. (Nat. Cell Biol. 1999)
    4. Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. (PubMed id 19086031)1, 2, 9 Rufanova V.A.... Sorokin A. (J. Cell. Physiol. 2009)
    5. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. (PubMed id 22081014)1, 2 Mace P.D.... Riedl S.J. (Nat. Struct. Mol. Biol. 2011)
    6. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (Eur. J. Hum. Genet. 2010)
    7. Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. (PubMed id 17038317)1, 2 Modzelewska K.... Keely P.J. (J. Biol. Chem. 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading. (PubMed id 11158326)1, 2 Prasad N.... Decker S.J. (Mol. Cell. Biol. 2001)
    10. Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site. (PubMed id 8413311)1, 3 Dorssers L.C....Kok E.M. (Mol. Endocrinol. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9564 HGNC: 971 AceView: BCAR1 Ensembl:ENSG00000050820 euGenes: HUgn9564
    ECgene: BCAR1 Kegg: 9564 H-InvDB: BCAR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BCAR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BCAR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BCAR1 gene:
    Search GeneIP for patents involving BCAR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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