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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BCAN Gene

protein-coding GIFtS: 60
GCID: GC01P156611

brevican

Explore 4 diseases affiliated with
BCAN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Brevican¹		Chondroitin Sulfate Proteoglycan 7² ³
BEHAB¹ ² ³		MGC13038¹
CSPG7¹ ² ³		Brevican Core Protein²
Brain-Enriched Hyaluronan-Binding Protein² ³		Chondroitin Sulfate Proteoglycan BEHAB²

External Ids:	HGNC: 23059¹	Entrez Gene: 63827²	Ensembl: ENSG00000132692⁷	OMIM: 600347⁵	UniProtKB: Q96GW7³

Export aliases for BCAN gene to outside databases

Previous GC identifers: GC01P154481 GC01P152377 GC01P153390 GC01P153828 GC01P153424 GC01P154878 GC01P127969

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCAN:

This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed

in the central nervous system. This protein is developmentally regulated and may function in the formation of the

brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility

of brain tumor cells. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: PGCB_HUMAN, Q96GW7

Function: May play a role in the terminally differentiating and the adult nervous system during postnatal development.

Could stabilize interactions between hyaluronan (HA) and brain proteoglycans

Gene Wiki entry for BCAN (Brevican)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BCAN gene promoter:
AhR p53 p300 NRSF form 1 STAT5A NRSF form 2 YY1 Arnt
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BCAN promoter sequence

Search SABiosciences Chromatin IP Primers for BCAN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCAN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q31

BCAN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCAN gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P156611: view genomic region (about GC identifiers)

Start:	156,611,182 bp from pter	End:	156,629,324 bp from pter
Size:	18,143 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PGCB_HUMAN, Q96GW7 (See protein sequence)

Recommended Name: Brevican core protein precursor

Size: 911 amino acids; 99118 Da

Subunit: Interacts with TNR (By similarity)

Subcellular location: Isoform 1: Secreted, extracellular space, extracellular matrix

Subcellular location: Isoform 2: Membrane; Lipid-anchor, GPI-anchor

Developmental stage: Isoform 1 is highly expressed from birth through 8 years of age and is down-regulated by 20 years

of age to low levels that are maintained in the normal adult cortex. Isoform 2 is expressed at uniformly low levels

throughout development

Secondary accessions: D3DVC2 Q5SZ10 Q5T3I5 Q8TBB9 Q9HBK1 Q9HBK4

Alternative splicing: 2 isoforms: Q96GW7-1 Q96GW7-2 (GPI-anchor amidated asparagine on Asn-649 (Potential))

Explore the universe of human proteins at neXtProt for BCAN: NX_Q96GW7

Post-translational modifications:

Contains mostly chondroitin sulfate (By similarity). O-glycosylated with a core 1 or possibly core 8 glycan¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96GW7

BCAN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_068767.3 NP_940819.1

ENSEMBL proteins:

ENSP00000392731 ENSP00000331210 ENSP00000389898 ENSP00000401709 ENSP00000354925

Reactome Protein details: Q96GW7
Human Recombinant Protein Products:

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	R&D Systems Recombinant & Natural Proteins for BCAN (Brevican)
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	Novus Biologicals BCAN Proteins Novus Biologicals BCAN Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for BCAN

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	--	--
GO:0005624	membrane fraction	--	--
GO:0005796	Golgi lumen	TAS	--

BCAN for ontologies About GeneDecksing

BCAN Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for BCAN (Brevican)
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	GenScript Custom Superior Antibodies Services for BCAN
	Novus Biologicals BCAN Antibodies
	Search for Antibodies for BCAN at Abcam
	Uscn Antibodies for BCAN
	ThermoFisher Antibody for BCAN

Assay Products for BCAN:

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	GenScript Custom Assay Services for BCAN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for BCAN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BCAN for domains About GeneDecksing

5/13 InterPro domains/families (see all 13):

IPR007110 Ig-like_dom

IPR016187 C-type_lectin_fold

IPR003006 Ig/MHC_CS

IPR000742 EG-like_dom

IPR018378 C-type_lectin_CS

Graphical View of Domain Structure for InterPro Entry Q96GW7

ProtoNet protein and cluster: Q96GW7

4 Blocks protein families:

IPB000436 Sushi domain/SCR domain/CCP module

IPB000538 Link domain

IPB002353 Type II antifreeze protein signature

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: PGCB_HUMAN, Q96GW7

Similarity: Belongs to the aggrecan/versican proteoglycan family

Similarity: Contains 1 C-type lectin domain

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

Similarity: Contains 2 Link domains

Similarity: Contains 1 Sushi (CCP/SCR) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PGCB_HUMAN, Q96GW7

Function: May play a role in the terminally differentiating and the adult nervous system during postnatal development.

Could stabilize interactions between hyaluronan (HA) and brain proteoglycans

miRNA Products:		OriGene 3'-UTR Clone (see all 2): BCAN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCAN
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate BCAN (see all 19):
		hsa-miR-125a-5p hsa-miR-520d-5p hsa-miR-1914* hsa-miR-513a-5p hsa-miR-132 hsa-miR-1304 hsa-miR-633 hsa-miR-125b

		SwitchGear 3'UTR luciferase reporter plasmid: BCAN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCAN (see all 7) OriGene shRNA RFP: BCAN OriGene siRNA: BCAN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCAN

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for BCAN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCAN (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCAN (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): BCAN (NM_021948)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BCAN
		Search LifeMap BioReagents cell lines for BCAN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAN

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005540	hyaluronic acid binding	IEA	--
GO:0030246	carbohydrate binding	IEA	--

BCAN for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for BCAN:

Increased HPV18 LCR reporter a

Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Bcan):

behavior/neurological

nervous system

BCAN for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/15 pathways (see all 15)
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIID - Sanfilippo syndrome D	1.00
MPS I - Hurler syndrome	1.00	MPS IX - Natowicz syndrome	1.00
Mucopolysaccharidoses	1.00	MPS II - Hunter syndrome	1.00
MPS IV - Morquio syndrome A	1.00	Glycosaminoglycan metabolism	1.00

DSPGs are secreted

DSPG and CSPG translocate to the lysosome for degradation	1.00	CSPG is secreted	1.00
DSPGs are secreted	1.00	Dermatan sulfate biosynthesis	0.70
CS is cleaved from its proteoglycan	1.00	CS/DS degradation	0.54
DS is cleaved from its proteoglycan	1.00

Cell adhesion_Cell-matrix glycoconjugates

Cell adhesion_Cell-matrix glycoconjugates

1.00

Cell adhesion Cell-matrix glycoconjugates

0.97

A tetrasaccharide linker sequence is required for GAG synthesis

A tetrasaccharide linker sequence is required for GAG synthesis

1.00

Chondroitin sulfate/dermatan sulfate metabolism

0.54

Disease

Disease

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for BCAN

Cell adhesion Cell-matrix glycoconjugates

1 GeneGo (Thomson Reuters) Pathway for BCAN

Cell adhesion Cell-matrix glycoconjugates

5/27 Reactome Pathways for BCAN (see all 27)

	Chondroitin sulfate/dermatan sulfate metabolism
	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	DSPG and CSPG translocate to the lysosome for degradation
	Disease

BCAN for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BCAN

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/49 Interacting proteins for BCAN (Q96GW7^{2, 3} ENSP00000331210⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 49)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FBLN2	P98095³, ENSP00000384169⁴	I2D: score=2 STRING: ENSP00000384169
MMP1	P03956³, ENSP00000322788⁴	I2D: score=2 STRING: ENSP00000322788
MMP13	P45452³, ENSP00000260302⁴	I2D: score=2 STRING: ENSP00000260302
MMP2	P08253³, ENSP00000219070⁴	I2D: score=2 STRING: ENSP00000219070
MMP7	P09237³, ENSP00000260227⁴	I2D: score=2 STRING: ENSP00000260227

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0007155	cell adhesion	IEA	--
GO:0021766	hippocampus development	IEA	--
GO:0030203	glycosaminoglycan metabolic process	TAS	--
GO:0030204	chondroitin sulfate metabolic process	TAS	--

BCAN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BCAN

1 HMDB Compound for BCAN About this table

Compound	Synonyms	CAS #	PubMed Ids
Hyaluronic acid	hyaluronic acid	9004-61-9	--

Search CenterWatch for drugs/clinical trials and news about BCAN / PGCB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BCAN gene (2 alternative transcripts):

NM_021948.4 NM_198427.1

Unigene Cluster for BCAN:

Brevican

Hs.516904 [show with all ESTs]

Unigene Representative Sequence: AY358372

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000441358 ENST00000329117(uc001fpp.3) ENST00000457777 ENST00000424639

ENST00000479949 ENST00000361588(uc001fpo.3) ENST00000491823 ENST00000496038

miRNA Products:		OriGene 3'-UTR Clone (see all 2): BCAN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCAN
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate BCAN (see all 19):
		hsa-miR-125a-5p hsa-miR-520d-5p hsa-miR-1914* hsa-miR-513a-5p hsa-miR-132 hsa-miR-1304 hsa-miR-633 hsa-miR-125b

		SwitchGear 3'UTR luciferase reporter plasmid: BCAN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCAN (see all 7) OriGene shRNA RFP: BCAN OriGene siRNA: BCAN
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCAN (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCAN (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): BCAN (NM_021948)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCAN Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCAN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCAN

Additional cDNA sequence:

AB209570.1 AF228710.1 AF229053.1 AK289759.1 AL137504.1 AY007241.1 AY358372.1 BC009117.1

BC013234.1 BC022938.1 BC023209.1 BC027971.1 BC029313.1 BC029348.1 BC035457.1

21 DOTS entries:

DT.110521 DT.101984636 DT.86846012 DT.121406541 DT.101984634 DT.100806730 DT.436076 DT.92457078

DT.92457091 DT.92457086 DT.92457087 DT.95088684 DT.100806732 DT.75186146 DT.92457081 DT.95088681

DT.95142948 DT.95209711 DT.100030847 DT.91705336 DT.95254987

24/394 AceView cDNA sequences (see all 394):

BF528870 AW298823 BF348230 BF527689 BG913406 NM_021948 BG910211 BF526392

BI554160 BM708927 BG818928 AW296993 BG818856 CB153314 BG818851 AW291404

BG819108 BC035457 CD673033 BF527186 BC029348 CB153420 BM693513 BC027971

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for BCAN (see all 12) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17	^
SP1:															-		-		-
SP2:																	-
SP3:																																											-
SP4:									-								-
SP5:																	-

ExUns:	18a	·	18b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for BCAN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BCAN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGAGGGGTG

About this image

BCAN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Ovary

Ovary

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Testis

Brain

Brain

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)

Bone, Cartilage, Limb

See BCAN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BCAN

SOURCE GeneReport for Unigene cluster: Hs.516904

SABiosciences Custom PCR Arrays for BCAN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCAN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat BCAN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCAN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCAN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BCAN gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BCAN¹	brevican	64.31(n) 57.64(a)		425976 XM_423655.3 XP_423655.3
lizard (Anolis carolinensis)	Reptilia	BCAN⁶	--	38(a)	1 ↔ 1	AAWZ02037112(2211-18007)
African clawed frog (Xenopus laevis)	Amphibia	AF325324.1²	--	75.02(n)		AF325324.1
zebrafish (Danio rerio)	Actinopterygii	bcan¹	brevican	58.66(n) 55.26(a)		334113 NM_001083813.1 NP_001077282.1

ENSEMBL Gene Tree for BCAN (if available)
TreeFam Gene Tree for BCAN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BCAN gene

HAPLN1² HAPLN4² HAPLN3² ACAN² NCAN² VCAN² HAPLN2²

9 SIMAP similar genes for BCAN using alignment to 5 protein entries: PGCB_HUMAN (see all proteins):

DKFZp761L191 HABP2 VCAN ACAN HAPLN3 HAPLN2

HAPLN1 HAPLN4 CSPG3 variant protein

BCAN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2005506^1,2		--	127968001(+)	`gtttcG/Actatg`	2	--	us2k¹		2		NA WA	120
rs73000708^1,2	C,	--	127968091(+)	`GACACC/TGCACC`	2	--	us2k¹		2		WA	120
rs116702814^1,2	C,F,	--	127968685(+)	`CGCTGA/CGGAGT`	2	--	us2k¹		1		WA	118
rs59938816^1,2	C,	--	127968718(+)	`GCCCAG/CCCCCT`	2	--	us2k¹		1		WA	2
rs3795735^1,2	C,F,H,	--	127968977(+)	`CACAGG/AAGCCA`	2	--	us2k¹		8		NS EA NA	726
rs12139785^1,2	C,H	--	127969314(+)	`TGAACG/CATGTC`	2	--	us2k¹		4		NS EA	418
rs113194954^1,2		--	127969750(+)	`GTCAGC/TCCTTG`	2	--	int¹		2		CSA WA	120
rs12567353^1,2	C,F,H	--	127970023(+)	`GTCCTT/CGCCTC`	2	--	int¹		5		NS EA NA	412
rs76795137^1,2		--	127970869(+)	`TTGTGC/TCTCCC`	2	--	int¹		0	--	--	--	--
rs111583294^1,2	C,	--	127970909(+)	`TTCCTA/GTGGGA`	2	--	int¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for BCAN (156611182 - 156629324 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BCAN: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCAN

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BCAN for disorders           About GeneDecksing

OMIM gene information: 600347    OMIM disorders: --

4 diseases for BCAN:    About MalaCards

malignant glioma glioblastoma schizophrenia neuronitis

1 disease from the University of Copenhagen DISEASES database for BCAN:

Malignant glioma

Human Genome Epidemiology (HuGE) Navigator: BCAN (2 documents)

Export disorders for BCAN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BCAN gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with BCAN)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma. (PubMed id 11054543)^{1, 2, 3} Gary S.C.... Hockfield S. (2000)
Human BRAL1 and BCAN genes that belong to the link-mo dule superfamily are tandemly arranged on chromosome 1q21-23. (PubMed id 11873941)^{1, 3, 9} Nomoto H....Ninomiya Y. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma. (PubMed id 21997179)¹ Varga I....Klekner A. (2012)
Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associa ted with disease risk and cortical surface area. (PubMed id 20950796)¹ KAohler A.K....Andreassen O.A. (2011)
Confirmation of genomewide association signals in Chi nese Han population reveals risk loci for ischemic stroke. (PubMed id 19910543)¹ Ding H....Wang D.W. (2010)
Enrichment of glycopeptides for glycan structure and attachment site identification. (PubMed id 19838169)² Nilsson J.... Larson G. (2009)
The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility. (PubMed id 18611854)¹ Hu B....Viapiano M.S. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 63827	HGNC: 23059	AceView: BCAN	Ensembl:ENSG00000132692	euGenes: HUgn63827
ECgene: BCAN	H-InvDB: BCAN

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BCAN	Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_212

Intellectual Property for BCAN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for BCAN gene:
Search GeneIP for patents involving BCAN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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