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Aliases for BCAN Gene

Aliases for BCAN Gene

  • Brevican 2 3 5
  • Chondroitin Sulfate Proteoglycan 7 2 3 4
  • Brain-Enriched Hyaluronan-Binding Protein 3 4
  • BEHAB 3 4
  • CSPG7 3 4
  • Chondroitin Sulfate Proteoglycan BEHAB 3
  • Brevican Proteoglycan 2
  • Brevican Core Protein 3

External Ids for BCAN Gene

Previous GeneCards Identifiers for BCAN Gene

  • GC01P154481
  • GC01P152377
  • GC01P153390
  • GC01P153828
  • GC01P153424
  • GC01P154878
  • GC01P156611
  • GC01P127969

Summaries for BCAN Gene

Entrez Gene Summary for BCAN Gene

  • This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

GeneCards Summary for BCAN Gene

BCAN (Brevican) is a Protein Coding gene. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates and Metabolism. GO annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is ACAN.

UniProtKB/Swiss-Prot for BCAN Gene

  • May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

Gene Wiki entry for BCAN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAN Gene

Genomics for BCAN Gene

Regulatory Elements for BCAN Gene

Enhancers for BCAN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F156689 0.7 FANTOM5 ENCODE 12.4 +50.7 50664 5.9 MLX CREB3L1 ZFP64 DMAP1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 MCM3 KIAA0907 RRNAD1 LOC105371453 BCAN LOC246784 ISG20L2 HDGF PRCC MSTO2P NAXE
GH01F156486 1.5 FANTOM5 Ensembl ENCODE 12.1 -142.5 -142527 25.4 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 RRNAD1 KIAA0907 LOC246784 ENSG00000271267 SSR2 GLMP MEF2D ENSG00000229961 DAP3P1 TSACC
GH01F156453 0.5 Ensembl 10.8 -188.0 -187990 0.4 ZBTB48 CEBPB FOS MIR9-1 HAPLN2 RHBG CCT3 BCAN NAXE TSACC ENSG00000236947 C1orf61
GH01F156450 0.2 ENCODE 10.8 -189.5 -189540 1.7 ATF1 CREB3L1 SIN3A GLIS2 ZNF548 KDM4B ZNF263 SP3 YY2 NFYC KIAA0907 RRNAD1 MSTO2P LOC246784 MIR9-1 ENSG00000271267 HAPLN2 CCT3 RHBG BCAN
GH01F156569 0.9 FANTOM5 ENCODE 10.7 -69.8 -69847 3.3 ATF1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 GLI4 ZNF2 ETS1 ZNF143 NAXE PEAR1 MEF2D MSTO2P BCAN CCT3 TSACC GPATCH4 TTC24 IQGAP3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BCAN on UCSC Golden Path with GeneCards custom track

Promoters for BCAN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001750530 610 401 ZNF263 CTCF MAZ SUZ12 CBX2 ZBTB8A GLIS2 POLR2A KLF9 ZBTB33

Genomic Location for BCAN Gene

Chromosome:
1
Start:
156,641,390 bp from pter
End:
156,659,532 bp from pter
Size:
18,143 bases
Orientation:
Plus strand

Genomic View for BCAN Gene

Genes around BCAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAN Gene

Proteins for BCAN Gene

  • Protein details for BCAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GW7-PGCB_HUMAN
    Recommended name:
    Brevican core protein
    Protein Accession:
    Q96GW7
    Secondary Accessions:
    • D3DVC2
    • Q5SZ10
    • Q5T3I5
    • Q8TBB9
    • Q9HBK1
    • Q9HBK4

    Protein attributes for BCAN Gene

    Size:
    911 amino acids
    Molecular mass:
    99118 Da
    Quaternary structure:
    • Interacts with TNR.

    Alternative splice isoforms for BCAN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCAN Gene

Post-translational modifications for BCAN Gene

  • Contains mostly chondroitin sulfate (By similarity). O-glycosylated with a core 1 or possibly core 8 glycan.
  • Glycosylation at Asn 130, Asn 337, Thr 540, Ser 905, and Ser 906
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for BCAN Gene

Domains & Families for BCAN Gene

Suggested Antigen Peptide Sequences for BCAN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96GW7

UniProtKB/Swiss-Prot:

PGCB_HUMAN :
  • Contains 1 C-type lectin domain.
  • Belongs to the aggrecan/versican proteoglycan family.
Domain:
  • Contains 1 C-type lectin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Contains 2 Link domains.
  • Contains 1 Sushi (CCP/SCR) domain.
Family:
  • Belongs to the aggrecan/versican proteoglycan family.
genes like me logo Genes that share domains with BCAN: view

Function for BCAN Gene

Molecular function for BCAN Gene

UniProtKB/Swiss-Prot Function:
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

Gene Ontology (GO) - Molecular Function for BCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent IBA --
GO:0005540 hyaluronic acid binding IBA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with BCAN: view
genes like me logo Genes that share phenotypes with BCAN: view

Animal Models for BCAN Gene

MGI Knock Outs for BCAN:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCAN Gene

Localization for BCAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCAN Gene

Isoform 1: Secreted, extracellular space, extracellular matrix.
Isoform 2: Membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCAN Gene COMPARTMENTS Subcellular localization image for BCAN gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
golgi apparatus 4
plasma membrane 3
cytosol 2
mitochondrion 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for BCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA,IBA --
GO:0005796 Golgi lumen TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with BCAN: view

Pathways & Interactions for BCAN Gene

genes like me logo Genes that share pathways with BCAN: view

Gene Ontology (GO) - Biological Process for BCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IBA --
GO:0007155 cell adhesion IBA --
GO:0007417 central nervous system development IBA --
GO:0021766 hippocampus development IEA --
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with BCAN: view

No data available for SIGNOR curated interactions for BCAN Gene

Drugs & Compounds for BCAN Gene

(1) Drugs for BCAN Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma 439
genes like me logo Genes that share compounds with BCAN: view

Transcripts for BCAN Gene

Unigene Clusters for BCAN Gene

Brevican:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCAN Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
SP1: - - -
SP2: -
SP3: -
SP4: - -
SP5: -
SP6: -
SP7:
SP8: -
SP9:
SP10: - - - - - - - - -
SP11: - - - -
SP12:

ExUns: 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for BCAN Gene

GeneLoc Exon Structure for
BCAN
ECgene alternative splicing isoforms for
BCAN

Expression for BCAN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BCAN Gene

mRNA differential expression in normal tissues according to GTEx for BCAN Gene

This gene is overexpressed in Brain - Amygdala (x7.3), Brain - Caudate (basal ganglia) (x5.2), Brain - Hippocampus (x5.2), Brain - Putamen (basal ganglia) (x5.1), Brain - Nucleus accumbens (basal ganglia) (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.1), and Brain - Substantia nigra (x4.0).

Protein differential expression in normal tissues from HIPED for BCAN Gene

This gene is overexpressed in Frontal cortex (30.7), Brain (19.6), and Cerebrospinal fluid (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BCAN Gene



Protein tissue co-expression partners for BCAN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BCAN Gene:

BCAN

SOURCE GeneReport for Unigene cluster for BCAN Gene:

Hs.516904
genes like me logo Genes that share expression patterns with BCAN: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for BCAN Gene

Orthologs for BCAN Gene

This gene was present in the common ancestor of animals.

Orthologs for BCAN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCAN 34 35
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia BCAN 34 35
  • 89.27 (n)
dog
(Canis familiaris)
Mammalia BCAN 34 35
  • 87.78 (n)
rat
(Rattus norvegicus)
Mammalia Bcan 34
  • 83.49 (n)
mouse
(Mus musculus)
Mammalia Bcan 34 16 35
  • 83.37 (n)
oppossum
(Monodelphis domestica)
Mammalia BCAN 35
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 52 (a)
ManyToMany
chicken
(Gallus gallus)
Aves BCAN 34 35
  • 70.81 (n)
lizard
(Anolis carolinensis)
Reptilia BCAN 35
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486298 34
  • 58.77 (n)
zebrafish
(Danio rerio)
Actinopterygii bcan 34 35
  • 59.01 (n)
worm
(Caenorhabditis elegans)
Secernentea clec-149 35
  • 23 (a)
OneToMany
Species where no ortholog for BCAN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BCAN Gene

ENSEMBL:
Gene Tree for BCAN (if available)
TreeFam:
Gene Tree for BCAN (if available)

Paralogs for BCAN Gene

Paralogs for BCAN Gene

genes like me logo Genes that share paralogs with BCAN: view

Variants for BCAN Gene

Sequence variations from dbSNP and Humsavar for BCAN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1016423 -- 156,644,500(+) CAATG(C/T)CTGGA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1056695 -- 156,652,460(+) AGGAG(A/G)AGTCA intron-variant, reference, missense
rs10796963 -- 156,655,780(+) AATCC(C/T)TCTGT intron-variant
rs10908513 -- 156,653,833(+) CAGCC(C/T)GGAGT intron-variant, downstream-variant-500B
rs1105300 -- 156,640,685(+) ATGCT(A/G)GGATT nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BCAN Gene

Variant ID Type Subtype PubMed ID
nsv521401 CNV loss 19592680
nsv521552 CNV loss 19592680
nsv523181 CNV loss 19592680

Variation tolerance for BCAN Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.82; 86.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCAN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCAN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCAN Gene

Disorders for BCAN Gene

Relevant External Links for BCAN

Genetic Association Database (GAD)
BCAN
Human Genome Epidemiology (HuGE) Navigator
BCAN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCAN

No disorders were found for BCAN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCAN Gene

Publications for BCAN Gene

  1. Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23. (PMID: 11873941) Nomoto H. … Ninomiya Y. (Acta Med. Okayama 2002) 2 3 22 64
  2. cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma. (PMID: 11054543) Gary S.C. … Hockfield S. (Gene 2000) 2 3 4 64
  3. Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke. (PMID: 19910543) Ding H. … Wang D.W. (Stroke 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for BCAN Gene

Sources for BCAN Gene

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