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BCAN Gene

protein-coding   GIFtS: 63
GCID: GC01P156611

Brevican

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
brevican1 2     CSPG72 3
Chondroitin Sulfate Proteoglycan 71 2 3     Brevican Proteoglycan1
Brain-Enriched Hyaluronan-Binding Protein2 3     Brevican Core Protein2
BEHAB2 3     Chondroitin Sulfate Proteoglycan BEHAB2

External Ids:    HGNC: 230591   Entrez Gene: 638272   Ensembl: ENSG000001326927   OMIM: 6003475   UniProtKB: Q96GW73   

Export aliases for BCAN gene to outside databases

Previous GC identifers: GC01P154481 GC01P152377 GC01P153390 GC01P153828 GC01P153424 GC01P154878 GC01P127969


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BCAN Gene:
This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically
expressed in the central nervous system. This protein is developmentally regulated and may function in the
formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the
growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants.
(provided by RefSeq, Sep 2011)

GeneCards Summary for BCAN Gene:
BCAN (brevican) is a protein-coding gene. Diseases associated with BCAN include morquio syndrome b, and sly syndrome. GO annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is HAPLN4.

UniProtKB/Swiss-Prot: PGCB_HUMAN, Q96GW7
Function: May play a role in the terminally differentiating and the adult nervous system during postnatal
development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans

Gene Wiki entry for BCAN (Brevican) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the BCAN gene promoter:
         AhR   p53   p300   NRSF form 1   STAT5A   NRSF form 2   YY1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BCAN promoter sequence
   Search Chromatin IP Primers for BCAN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCAN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q31

BCAN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCAN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156611:  view genomic region     (about GC identifiers)

Start:
156,611,182 bp from pter      End:
156,629,324 bp from pter
Size:
18,143 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PGCB_HUMAN, Q96GW7 (See protein sequence)
Recommended Name: Brevican core protein precursor  
Size: 911 amino acids; 99118 Da
Subunit: Interacts with TNR (By similarity)
Developmental stage: Isoform 1 is highly expressed from birth through 8 years of age and is down-regulated by 20
years of age to low levels that are maintained in the normal adult cortex. Isoform 2 is expressed at uniformly
low levels throughout development
Secondary accessions: D3DVC2 Q5SZ10 Q5T3I5 Q8TBB9 Q9HBK1 Q9HBK4
Alternative splicing: 2 isoforms:  Q96GW7-1   Q96GW7-2   (GPI-anchor amidated asparagine on Asn-649 (Potential))

Explore the universe of human proteins at neXtProt for BCAN: NX_Q96GW7

Explore proteomics data for BCAN at MOPED

Post-translational modifications: 

  • Contains mostly chondroitin sulfate (By similarity). O-glycosylated with a core 1 or possibly core 8 glycan1
  • Glycosylation2 at Asn130, Asn337, Thr540, Thr542, Ser905, Ser906
  • Modification sites at PhosphoSitePlus

  • See BCAN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_068767.3  NP_940819.1  

    ENSEMBL proteins: 
     ENSP00000392731   ENSP00000331210   ENSP00000389898   ENSP00000401709   ENSP00000476509  
     ENSP00000354925   ENSP00000476259  
    Reactome Protein details: Q96GW7

    BCAN Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for BCAN (Brevican)
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    OriGene Protein Over-expression Lysate for BCAN
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    Novus Biologicals BCAN Proteins
    Novus Biologicals BCAN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BCAN

    BCAN Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for BCAN (Brevican)
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    Novus Biologicals BCAN Antibodies
    Search for Antibodies for BCAN at Abcam
    Cloud-Clone Corp. Antibodies for BCAN
    ThermoFisher Antibody for BCAN
    LSBio Antibodies in human, mouse, rat for BCAN

    BCAN Assay Products:

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    Cloud-Clone Corp. ELISAs for BCAN
    Cloud-Clone Corp. CLIAs for BCAN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VSET: Immunoglobulin superfamily / V-set domain containing
    HYALECTAN: Proteoglycans / Extracellular Matrix : Hyalectans

    Selected InterPro protein domains (see all 13):
     IPR000742 EG-like_dom
     IPR003596 Ig_V-set_subgr
     IPR000436 Sushi_SCR_CCP
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q96GW7

    ProtoNet protein and cluster: Q96GW7

    4 Blocks protein domains:
    IPB000436 Sushi domain/SCR domain/CCP module
    IPB000538 Link domain
    IPB002353 Type II antifreeze protein signature
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: PGCB_HUMAN, Q96GW7
    Similarity: Belongs to the aggrecan/versican proteoglycan family
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain
    Similarity: Contains 2 Link domains
    Similarity: Contains 1 Sushi (CCP/SCR) domain


    BCAN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGCB_HUMAN, Q96GW7
    Function: May play a role in the terminally differentiating and the adult nervous system during postnatal
    development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005540hyaluronic acid binding IEA--
    GO:0030246carbohydrate binding IEA--
         
    BCAN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BCAN:
     Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bcan):
     behavior/neurological  nervous system 

    BCAN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BCAN
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCAN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCAN

    miRNA
    Products:
        
    miRTarBase miRNAs that target BCAN:
    hsa-mir-133a-3p (MIRT021697)

    Block miRNA regulation of human, mouse, rat BCAN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BCAN (see all 19):
    hsa-miR-125a-5p hsa-miR-520d-5p hsa-miR-1914* hsa-miR-513a-5p hsa-miR-132 hsa-miR-1304 hsa-miR-633 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidBCAN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BCAN
    Predesigned siRNA for gene silencing in human, mouse, rat BCAN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BCAN

    Clone
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    OriGene clones in human, mouse for BCAN (see all 12)
    OriGene ORF clones in mouse, rat for BCAN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BCAN (NM_021948)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAN

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for BCAN 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PGCB_HUMAN, Q96GW7: Isoform 1: Secreted, extracellular space, extracellular matrix
    PGCB_HUMAN, Q96GW7: Isoform 2: Membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus4
    lysosome4
    vacuole4
    plasma membrane3
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005796Golgi lumen TAS--
    GO:0031225anchored component of membrane IEA--
    GO:0043202lysosomal lumen TAS--

    BCAN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BCAN About   (see all 9)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    CS/DS degradation0.00
    A tetrasaccharide linker sequence is required for GAG synthesis0.51
    Dermatan sulfate biosynthesis0.00
    Chondroitin sulfate biosynthesis0.41
    3Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    4Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    5Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for BCAN
        Cell adhesion Cell-matrix glycoconjugates

    1 BioSystems Pathway for BCAN
        Spinal Cord Injury

    Selected Reactome Pathways for BCAN (see all 6)
        Dermatan sulfate biosynthesis
    ECM proteoglycans
    Degradation of the extracellular matrix
    CS/DS degradation
    A tetrasaccharide linker sequence is required for GAG synthesis



    BCAN for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BCAN
    Interactions:

        GeneGlobe Interaction Network for BCAN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BCAN (Q96GW72, 3 ENSP000003312104) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBLN2P980953, ENSP000003841694I2D: score=2 STRING: ENSP00000384169
    MMP1P039563, ENSP000003227884I2D: score=2 STRING: ENSP00000322788
    MMP13P454523, ENSP000002603024I2D: score=2 STRING: ENSP00000260302
    MMP2P082533, ENSP000002190704I2D: score=2 STRING: ENSP00000219070
    MMP7P092373, ENSP000002602274I2D: score=2 STRING: ENSP00000260227
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007155cell adhesion IEA--
    GO:0021766hippocampus development IEA--
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--

    BCAN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BCAN (PGCB)

    1 HMDB Compound for BCAN    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronic acidhyaluronic acid 9004-61-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BCAN gene (2 alternative transcripts): 
    NM_021948.4  NM_198427.1  

    Unigene Cluster for BCAN:

    Brevican
    Hs.516904  [show with all ESTs]
    Unigene Representative Sequence: AY358372
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441358 ENST00000329117(uc001fpp.3) ENST00000457777 ENST00000424639
    ENST00000479949 ENST00000361588(uc001fpo.3) ENST00000491823 ENST00000496038

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BCAN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BCAN (see all 19):
    hsa-miR-125a-5p hsa-miR-520d-5p hsa-miR-1914* hsa-miR-513a-5p hsa-miR-132 hsa-miR-1304 hsa-miR-633 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidBCAN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BCAN
    Predesigned siRNA for gene silencing in human, mouse, rat BCAN
    Clone
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    OriGene clones in human, mouse for BCAN (see all 12)
    OriGene ORF clones in mouse, rat for BCAN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BCAN (NM_021948)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAN
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for BCAN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BCAN
      QuantiTect SYBR Green Assays in human, mouse, rat BCAN
      QuantiFast Probe-based Assays in human, mouse, rat BCAN

    Additional mRNA sequence: 

    AB209570.1 AF228710.1 AF229053.1 AK289759.1 AL137504.1 AY007241.1 AY358372.1 BC009117.1 
    BC013234.1 BC022938.1 BC023209.1 BC027971.1 BC029313.1 BC029348.1 BC035457.1 

    21 DOTS entries:

    DT.110521  DT.101984636  DT.86846012  DT.121406541  DT.101984634  DT.100806730  DT.436076  DT.92457078 
    DT.92457091  DT.92457086  DT.92457087  DT.95088684  DT.100030847  DT.100806732  DT.75186146  DT.92457081 
    DT.95088681  DT.95142948  DT.95209711  DT.91705336  DT.95254987 

    Selected AceView cDNA sequences (see all 394):

    BG818851 BF527689 BG818856 CD673033 BM693513 BG910211 BF528870 BC029348 
    BC022938 BF338679 BC013234 AI272375 CB153236 CB152153 BM708927 NM_198427 
    BX445051 BF526392 BF345818 BG818218 BG818928 BG911420 CB153420 AW291404 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BCAN (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
    SP1:                                            -     -     -                                                                                                   
    SP2:                                                  -                                                                                                         
    SP3:                                                                                                                                -                           
    SP4:                          -                       -                                                                                                         
    SP5:                                                  -                                                                                                         

    ExUns: 18a · 18b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for BCAN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BCAN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGAGGGGTG
    BCAN Expression
    About this image


    BCAN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             Oligodendrocyte-like cells
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Adult Endothelial Cells Blood Brain Barrier
             Endothelial-like cells
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Sertoli cells Seminiferous Tubules
             Seminiferous Tubules
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
    BCAN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCAN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516904
        Custom PCR Arrays for BCAN
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BCAN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcan1 , 5 brevican1, 5 83.37(n)1
    84.35(a)1
      3 (38.78 cM)5
    120321  NM_007529.21  NP_031555.21 
     879875315 
    chicken
    (Gallus gallus)
    Aves BCAN1 brevican 70.81(n)
    66.83(a)
      425976  XM_423655.4  XP_423655.4 
    lizard
    (Anolis carolinensis)
    Reptilia BCAN6
    brevican
    38(a)
    1 ↔ 1
    AAWZ02037112(2066-18007)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF325324.12   -- 75.02(n)    AF325324.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bcan1 brevican 59.01(n)
    55.74(a)
      334113  NM_001083813.1  NP_001077282.1 
    worm
    (Caenorhabditis elegans)
    Secernentea clec-1496
    Protein CLEC-149 (clec-149) mRNA, complete cds
    23(a)
    1 → many
    III(823222-826412) WBGene00019328


    ENSEMBL Gene Tree for BCAN (if available)
    TreeFam Gene Tree for BCAN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BCAN gene
    HAPLN42  HAPLN12  HAPLN32  ACAN2  CLEC19A2  NCAN2  HAPLN22  VCAN2  
    9 SIMAP similar genes for BCAN using alignment to 7 protein entries:     PGCB_HUMAN (see all proteins):
    DKFZp761L191    HABP2    VCAN    ACAN    HAPLN3    HAPLN2
    HAPLN1    HAPLN4    CSPG3 variant protein

    BCAN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BCAN (see all 536)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57420881,2
    C--156610207(+) TTTTT-/TTTT  
            
    GAGAG
    2 -- us2k11Minor allele frequency- TTTT:0.00NA 2
    rs2001542011,2
    C--156610207(+) TTTTC-/TTTT  
            
    TTTTT
    2 -- us2k10--------
    rs57779961,2
    C--156614964(+) CCCCC-/CTTAGT 2 -- int1 trp30--------
    rs32160431,2
    C--156621690(-) TGCAAG/-GCATC 2 -- int13Minor allele frequency- -:0.00NA CSA 6
    rs75297351,2
    C,F,H--163108394(+) CAAGAA/GCTGTG 2 -- us2k16Minor allele frequency- G:0.01NS EA WA 620
    rs1483127611,2
    C--163108436(+) TCAGCC/TGCTTG 2 -- us2k10--------
    rs1873566951,2
    --163108499(+) TAGGCC/TGGACA 2 -- us2k10--------
    rs1172985411,2
    F--163108532(+) CCTGAG/AGAAGG 2 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1166087471,2
    F--163108705(+) ATTCAA/GTTCAA 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1908267201,2
    --163108730(+) ACGAAA/GTAAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for BCAN (156611182 - 156629324 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BCAN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521552CNV Loss19592680
    nsv521401CNV Loss19592680
    nsv872473CNV Loss21882294
    nsv523181CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BCAN
    DNA2.0 Custom Variant and Variant Library Synthesis for BCAN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600347    OMIM disorders: --

    11 diseases for BCAN:    
    About MalaCards
    morquio syndrome b    sly syndrome    mucopolysaccharidoses    spinal cord injury
    malignant glioma    astrocytoma    schizophrenia    cerebritis
    endotheliitis    neuronitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for BCAN:
    Malignant glioma

    BCAN for disorders           About GeneDecksing

    Genetic Association Database (GAD): BCAN
    Human Genome Epidemiology (HuGE) Navigator: BCAN (2 documents)

    Export disorders for BCAN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BCAN gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with BCAN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma. (PubMed id 11054543)1, 2, 3 Gary S.C.... Hockfield S. (Gene 2000)
    2. Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23. (PubMed id 11873941)1, 3, 9 Nomoto H....Ninomiya Y. (Acta Med. Okayama 2002)
    3. Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke. (PubMed id 19910543)1, 4 Ding H....Wang D.W. ( a journal of cerebral circulation 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma. (PubMed id 21997179)1 Varga I....Klekner A. (Pathol. Oncol. Res. 2012)
    8. Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis. (PubMed id 22930747)1 Faryna M....Gerhauser C. (FASEB J. 2012)
    9. Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area. (PubMed id 20950796)1 KAohler A.K....Andreassen O.A. (Biol. Psychiatry 2011)
    10. Enrichment of glycopeptides for glycan structure and attachment site identification. (PubMed id 19838169)2 Nilsson J.... Larson G. (Nat. Methods 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63827 HGNC: 23059 AceView: BCAN Ensembl:ENSG00000132692 euGenes: HUgn63827
    ECgene: BCAN H-InvDB: BCAN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BCAN Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_212

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BCAN gene:
    Search GeneIP for patents involving BCAN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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