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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BCAN Gene

protein-coding   GIFtS: 62
GCID: GC01P156611

Brevican

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
brevican1 2     CSPG72 3
Chondroitin Sulfate Proteoglycan 71 2 3     Brevican Proteoglycan1
Brain-Enriched Hyaluronan-Binding Protein2 3     Brevican Core Protein2
BEHAB2 3     Chondroitin Sulfate Proteoglycan BEHAB2

External Ids:    HGNC: 230591   Entrez Gene: 638272   Ensembl: ENSG000001326927   OMIM: 6003475   UniProtKB: Q96GW73   

Export aliases for BCAN gene to outside databases

Previous GC identifers: GC01P154481 GC01P152377 GC01P153390 GC01P153828 GC01P153424 GC01P154878 GC01P127969


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCAN Gene:
This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically
expressed in the central nervous system. This protein is developmentally regulated and may function in the
formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the
growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants.
(provided by RefSeq, Sep 2011)

GeneCards Summary for BCAN Gene: 
BCAN (brevican) is a protein-coding gene. Diseases associated with BCAN include morquio syndrome b, and malignant glioma, and among its related super-pathways are Metabolism of carbohydrates and Chondroitin sulfate/dermatan sulfate metabolism. GO annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is HAPLN4.

UniProtKB/Swiss-Prot: PGCB_HUMAN, Q96GW7
Function: May play a role in the terminally differentiating and the adult nervous system during postnatal
development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans

Gene Wiki entry for BCAN (Brevican) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BCAN gene promoter:
         AhR   p53   p300   NRSF form 1   STAT5A   NRSF form 2   YY1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BCAN promoter sequence
   Search SABiosciences Chromatin IP Primers for BCAN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCAN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q31

BCAN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCAN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156611:  view genomic region     (about GC identifiers)

Start:
156,611,182 bp from pter      End:
156,629,324 bp from pter
Size:
18,143 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PGCB_HUMAN, Q96GW7 (See protein sequence)
Recommended Name: Brevican core protein precursor  
Size: 911 amino acids; 99118 Da
Subunit: Interacts with TNR (By similarity)
Subcellular location: Isoform 1: Secreted, extracellular space, extracellular matrix
Subcellular location: Isoform 2: Membrane; Lipid-anchor, GPI-anchor
Developmental stage: Isoform 1 is highly expressed from birth through 8 years of age and is down-regulated by 20
years of age to low levels that are maintained in the normal adult cortex. Isoform 2 is expressed at uniformly
low levels throughout development
Secondary accessions: D3DVC2 Q5SZ10 Q5T3I5 Q8TBB9 Q9HBK1 Q9HBK4
Alternative splicing: 2 isoforms:  Q96GW7-1   Q96GW7-2   (GPI-anchor amidated asparagine on Asn-649 (Potential))

Explore the universe of human proteins at neXtProt for BCAN: NX_Q96GW7

Explore proteomics data for BCAN at MOPED 

Post-translational modifications:

  • UniProtKB: Contains mostly chondroitin sulfate (By similarity). O-glycosylated with a core 1 or possibly core 8 glycan
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96GW7

  • BCAN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BCAN Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_068767.3  NP_940819.1  

    ENSEMBL proteins: 
     ENSP00000392731   ENSP00000331210   ENSP00000389898   ENSP00000401709   ENSP00000354925  
    Reactome Protein details: Q96GW7
    Human Recombinant Protein Products for BCAN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BCAN (Brevican)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for BCAN
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    Novus Biologicals BCAN Proteins
    Novus Biologicals BCAN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BCAN 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005796Golgi lumen TAS--
    GO:0031225anchored to membrane IEA--
    GO:0043202lysosomal lumen TAS--

    BCAN for ontologies           About GeneDecksing



    BCAN Antibody Products: 
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    Novus Biologicals BCAN Antibodies
    Abcam antibodies for BCAN
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    ThermoFisher Antibody for BCAN
    LSBio Antibodies in human, mouse, rat for BCAN 

    Assay Products for BCAN: 
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    Cloud-Clone Corp. ELISAs for BCAN 
    Cloud-Clone Corp. CLIAs for BCAN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    VSET: Immunoglobulin superfamily / V-set domain containing
    HYALECTAN: Proteoglycans / Extracellular Matrix : Hyalectans

    5/13 InterPro protein domains (see all 13):
     IPR007110 Ig-like_dom
     IPR016187 C-type_lectin_fold
     IPR003006 Ig/MHC_CS
     IPR000742 EG-like_dom
     IPR018378 C-type_lectin_CS

    Graphical View of Domain Structure for InterPro Entry Q96GW7

    ProtoNet protein and cluster: Q96GW7

    4 Blocks protein domains:
    IPB000436 Sushi domain/SCR domain/CCP module
    IPB000538 Link domain
    IPB002353 Type II antifreeze protein signature
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: PGCB_HUMAN, Q96GW7
    Similarity: Belongs to the aggrecan/versican proteoglycan family
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain
    Similarity: Contains 2 Link domains
    Similarity: Contains 1 Sushi (CCP/SCR) domain


    BCAN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGCB_HUMAN, Q96GW7
    Function: May play a role in the terminally differentiating and the adult nervous system during postnatal
    development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005540hyaluronic acid binding IEA--
    GO:0030246carbohydrate binding IEA--
         
    BCAN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BCAN:
     Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bcan):
     behavior/neurological  nervous system 

    BCAN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BCAN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BCAN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BCAN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BCAN 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCAN
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate BCAN (see all 19):
    hsa-miR-125a-5p hsa-miR-520d-5p hsa-miR-1914* hsa-miR-513a-5p hsa-miR-132 hsa-miR-1304 hsa-miR-633 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidBCAN 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BCAN (NM_021948)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAN
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                         Customized lentivirus expression plasmids for stable overexpression of BCAN 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BCAN About   (see all 11)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    2A tetrasaccharide linker sequence is required for GAG synthesis
    Chondroitin sulfate/dermatan sulfate metabolism0.54
    A tetrasaccharide linker sequence is required for GAG synthesis0.54
    3CS/DS degradation
    Dermatan sulfate biosynthesis0.44
    CS/DS degradation0.44
    4Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion Cell-matrix glycoconjugates0.97
    5Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for BCAN
        Cell adhesion Cell-matrix glycoconjugates


    1 GeneGo (Thomson Reuters) Pathway for BCAN
        Cell adhesion Cell-matrix glycoconjugates

    1 BioSystems Pathway for BCAN
        Spinal Cord Injury

    5/24        Reactome Pathways for BCAN (see all 24)
        Chondroitin sulfate/dermatan sulfate metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Dermatan sulfate biosynthesis



    BCAN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BCAN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for BCAN (Q96GW72, 3 ENSP000003312104) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBLN2P980953, ENSP000003841694I2D: score=2 STRING: ENSP00000384169
    MMP1P039563, ENSP000003227884I2D: score=2 STRING: ENSP00000322788
    MMP13P454523, ENSP000002603024I2D: score=2 STRING: ENSP00000260302
    MMP2P082533, ENSP000002190704I2D: score=2 STRING: ENSP00000219070
    MMP7P092373, ENSP000002602274I2D: score=2 STRING: ENSP00000260227
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007155cell adhesion IEA--
    GO:0021766hippocampus development IEA--
    GO:0030198extracellular matrix organization TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--

    BCAN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BCAN (PGCB)

    1 HMDB Compound for BCAN    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronic acidhyaluronic acid 9004-61-9--

    Search CenterWatch for drugs/clinical trials and news about BCAN / PGCB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BCAN gene (2 alternative transcripts): 
    NM_021948.4  NM_198427.1  

    Unigene Cluster for BCAN:

    Brevican
    Hs.516904  [show with all ESTs]
    Unigene Representative Sequence: AY358372
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441358 ENST00000329117(uc001fpp.3) ENST00000457777 ENST00000424639
    ENST00000479949 ENST00000361588(uc001fpo.3) ENST00000491823 ENST00000496038

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCAN
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate BCAN (see all 19):
    hsa-miR-125a-5p hsa-miR-520d-5p hsa-miR-1914* hsa-miR-513a-5p hsa-miR-132 hsa-miR-1304 hsa-miR-633 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidBCAN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BCAN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCAN
    Clone
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    OriGene clones in human, mouse for BCAN (see all 12)
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    GenScript: all cDNA clones in your preferred vector (see all 2): BCAN (NM_021948)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAN
    Sirion Biotech Customized lentivirus for stable overexpression of BCAN 
                         Customized lentivirus expression plasmids for stable overexpression of BCAN 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCAN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCAN

    Additional mRNA sequence: 

    AB209570.1 AF228710.1 AF229053.1 AK289759.1 AL137504.1 AY007241.1 AY358372.1 BC009117.1 
    BC013234.1 BC022938.1 BC023209.1 BC027971.1 BC029313.1 BC029348.1 BC035457.1 

    21 DOTS entries:

    DT.110521  DT.101984636  DT.86846012  DT.121406541  DT.101984634  DT.100806730  DT.436076  DT.92457078 
    DT.92457091  DT.92457086  DT.92457087  DT.95088684  DT.100030847  DT.100806732  DT.75186146  DT.92457081 
    DT.95088681  DT.95142948  DT.95209711  DT.91705336  DT.95254987 

    24/394 AceView cDNA sequences (see all 394):

    CB153236 NM_198427 BX445051 BF530989 BG910211 BF346969 BG819108 AW291404 
    BF347021 BG818851 CB155742 BG818856 CB152378 BC023209 AL538295 BF526392 
    T07293 CB153420 AF268002 BC029348 BF527186 BC027971 CB152153 BG913406 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for BCAN (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
    SP1:                                            -     -     -                                                                                                   
    SP2:                                                  -                                                                                                         
    SP3:                                                                                                                                -                           
    SP4:                          -                       -                                                                                                         
    SP5:                                                  -                                                                                                         

    ExUns: 18a · 18b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for BCAN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BCAN expression in normal human tissues (normalized intensities)      BCAN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGAGGGGTG
    BCAN Expression
    About this image


    BCAN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Adult Endothelial Cells Blood Brain Barrier
             Thalamus
             Fetal Neuronal Stem Cells (NSC)   
             brain/forebrain/telencephalon   
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Telencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Adult Endothelial Cells Blood Brain Barrier
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Melanocytes (Integumentary System)    fully expand to see all 3 entries
             Human EpiDermal Melanocytes-dark (HEM-dark)   

    See BCAN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BCAN

    SOURCE GeneReport for Unigene cluster: Hs.516904
        SABiosciences Custom PCR Arrays for BCAN
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCAN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BCAN gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcan1 , 5 brevican1, 5 83.11(n)1
    84.17(a)1
      3 (38.78 cM)5
    120321  NM_007529.21  NP_031555.21 
     879875315 
    chicken
    (Gallus gallus)
    Aves BCAN1 brevican 64.31(n)
    57.64(a)
      425976  XM_423655.3  XP_423655.3 
    lizard
    (Anolis carolinensis)
    Reptilia BCAN6
    Uncharacterized protein
    33(a)
    1 ↔ 1
    AAWZ02037112(2066-18007)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF325324.12   -- 75.02(n)    AF325324.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bcan1 brevican 58.66(n)
    55.26(a)
      334113  NM_001083813.1  NP_001077282.1 


    ENSEMBL Gene Tree for BCAN (if available)
    TreeFam Gene Tree for BCAN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BCAN gene
    HAPLN42  HAPLN12  HAPLN32  ACAN2  NCAN2  VCAN2  HAPLN22  
    9 SIMAP similar genes for BCAN using alignment to 5 protein entries:     PGCB_HUMAN (see all proteins):
    DKFZp761L191    HABP2    VCAN    ACAN    HAPLN3    HAPLN2
    HAPLN1    HAPLN4    CSPG3 variant protein

    BCAN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/536 SNPs in BCAN are shown (see all 536)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57420881,2
    C--156610207(+) TTTTT-/TTTT  
            
    GAGAG
    2 -- us2k11Minor allele frequency- TTTT:0.00NA 2
    rs2001542011,2
    C--156610207(+) TTTTC-/TTTT  
            
    TTTTT
    2 -- us2k10--------
    rs57779961,2
    C--156614964(+) CCCCC-/CTTAGT 2 -- int1 trp30--------
    rs32160431,2
    C--156621690(-) TGCAAG/-GCATC 2 -- int13Minor allele frequency- -:0.00NA CSA 6
    rs75297351,2
    C,F,H--163108394(+) CAAGAA/GCTGTG 2 -- us2k16Minor allele frequency- G:0.01NS EA WA 620
    rs1483127611,2
    C--163108436(+) TCAGCC/TGCTTG 2 -- us2k10--------
    rs1873566951,2
    --163108499(+) TAGGCC/TGGACA 2 -- us2k10--------
    rs1172985411,2
    F--163108532(+) CCTGAG/AGAAGG 2 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1166087471,2
    F--163108705(+) ATTCAA/GTTCAA 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1908267201,2
    --163108730(+) ACGAAA/GTAAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for BCAN (156611182 - 156629324 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BCAN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv521552CNV Loss19592680
    nsv521401CNV Loss19592680
    nsv872473CNV Loss21882294
    nsv523181CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600347    OMIM disorders: --

    6 diseases for BCAN:    About MalaCards
    morquio syndrome b    malignant glioma    glioblastoma    schizophrenia
    astrocytoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for BCAN:
    Malignant glioma

    BCAN for disorders           About GeneDecksing

    Genetic Association Database (GAD): BCAN
    Human Genome Epidemiology (HuGE) Navigator: BCAN (2 documents)

    Export disorders for BCAN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BCAN gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with BCAN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma. (PubMed id 11054543)1, 2, 3 Gary S.C.... Hockfield S. (2000)
    2. Human BRAL1 and BCAN genes that belong to the link-mo dule superfamily are tandemly arranged on chromosome 1q21-23. (PubMed id 11873941)1, 3, 9 Nomoto H....Ninomiya Y. (2002)
    3. Confirmation of genomewide association signals in Chi nese Han population reveals risk loci for ischemic stroke. (PubMed id 19910543)1, 4 Ding H....Wang D.W. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma. (PubMed id 21997179)1 Varga I....Klekner A. (2012)
    7. Genome-wide methylation screen in low-grade breast can cer identifies novel epigenetically altered genes as potential biomarkers for tu mor diagnosis. (PubMed id 22930747)1 Faryna M....Gerhauser C. (2012)
    8. Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associa ted with disease risk and cortical surface area. (PubMed id 20950796)1 KAohler A.K....Andreassen O.A. (2011)
    9. Enrichment of glycopeptides for glycan structure and attachment site identification. (PubMed id 19838169)2 Nilsson J.... Larson G. (2009)
    10. The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility. (PubMed id 18611854)1 Hu B....Viapiano M.S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 63827 HGNC: 23059 AceView: BCAN Ensembl:ENSG00000132692 euGenes: HUgn63827
    ECgene: BCAN H-InvDB: BCAN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BCAN Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_212

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BCAN gene:
    Search GeneIP for patents involving BCAN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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