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BCAM Gene

protein-coding   GIFtS: 60
GCID: GC19P045312

Basal Cell Adhesion Molecule (Lutheran Blood Group)

(Previous names: Lutheran blood group (Auberger b antigen included), basal...)
(Previous symbol: LU)
  See BCAM-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Basal Cell Adhesion Molecule (Lutheran Blood Group)1 2     CD2392
LU1 2 3 5     Antigen Identified By Monoclonal Antibody F82
Basal Cell Adhesion Molecule (Lu And Au Blood Groups)1 2     B-Cell Adhesion Molecule2
Auberger B Antigen2 3     Basal Cell Adhesion Molecule2
MSK192 3     Glycoprotein 95kDa2
B-CAM Cell Surface Glycoprotein2 3     CD239 Antigen3
F8/G253 Antigen2 3     Lutheran Antigen3
AU2 5     Lutheran Blood Group Glycoprotein3
Lutheran Blood Group (Auberger B Antigen Included)1     

External Ids:    HGNC: 67221   Entrez Gene: 40592   Ensembl: ENSG000001872447   OMIM: 6127735   UniProtKB: P508953   

Export aliases for BCAM gene to outside databases

Previous GC identifers: GC19P050005 GC19P041744


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BCAM Gene:
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for
the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a
single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial
cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define
some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene
result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, May 2012)

GeneCards Summary for BCAM Gene:
BCAM (basal cell adhesion molecule (Lutheran blood group)) is a protein-coding gene. Diseases associated with BCAM include testicular gonadoblastoma, and sickle cell disease. GO annotations related to this gene include transmembrane signaling receptor activity and laminin receptor activity. An important paralog of this gene is MCAM.

UniProtKB/Swiss-Prot: BCAM_HUMAN, P50895
Function: Laminin alpha-5 receptor. May mediate intracellular signaling

Gene Wiki entry for BCAM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the BCAM gene promoter:
         GR   Spz1   p53   ATF-2   NRSF form 1   NRSF form 2   E47   HNF-4alpha1   CRE-BP1   HEN1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BCAM promoter sequence
   Search Chromatin IP Primers for BCAM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BCAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q12-q13

BCAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCAM gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045312:  view genomic region     (about GC identifiers)

Start:
45,312,328 bp from pter      End:
45,324,678 bp from pter
Size:
12,351 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BCAM_HUMAN, P50895 (See protein sequence)
Recommended Name: Basal cell adhesion molecule precursor  
Size: 628 amino acids; 67405 Da
Developmental stage: Is under developmental control in liver and may also be regulated during differentiation in
other tissues. Up-regulated following malignant transformation in some cell types
Sequence caution: Sequence=EAW57297.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for BCAM:
2PET (3D)        2PF6 (3D)    
Secondary accessions: A8MYF9 A9YWT5 A9YWT6 Q86VC7

Explore the universe of human proteins at neXtProt for BCAM: NX_P50895

Explore proteomics data for BCAM at MOPED

Post-translational modifications: 

  • Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin1
  • Glycosylation2 at Asn321, Asn377, Asn383, Asn419, Asn439
  • Modification sites at PhosphoSitePlus

  • See BCAM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001013275.1  NP_005572.2  

    ENSEMBL proteins: 
     ENSP00000476710   ENSP00000270233   ENSP00000467100   ENSP00000468189  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    bloodgroup: Blood group antigens
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P50895

    ProtoNet protein and cluster: P50895

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: BCAM_HUMAN, P50895
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    Find genes that share domains with BCAM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BCAM_HUMAN, P50895
    Function: Laminin alpha-5 receptor. May mediate intracellular signaling

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS7777537
    GO:0005055laminin receptor activity IMP16236823
    GO:0005515protein binding ----
    GO:0043236laminin binding IMP16236823
         
    Find genes that share ontologies with BCAM           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for BCAM:
     Decreased Salmonella enterica   Decreased homologous recombina  Decreased viability of wild-ty  Increased cell number in G2M,  

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Bcam):
     cardiovascular system  digestive/alimentary  growth/size/body  mortality/aging  nervous system 
     normal  renal/urinary system  reproductive system 

    Find genes that share phenotypes with BCAM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BCAM: Bcamtm1Jhm Bcamtm1Ics

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    Selected qRT-PCR Assays for microRNAs that regulate BCAM (see all 24):
    hsa-miR-26a-2* hsa-miR-1321 hsa-miR-3125 hsa-miR-3916 hsa-miR-4314 hsa-miR-661 hsa-miR-637 hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidBCAM 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BCAM_HUMAN, P50895: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS9166867
    GO:0005887integral component of plasma membrane TAS7777537
    GO:0009897external side of plasma membrane IC16236823
    GO:0009986cell surface ----
    GO:0016020membrane ----

    Find genes that share ontologies with BCAM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BCAM
    Interactions:

        GeneGlobe Interaction Network for BCAM

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for BCAM (P508953 ENSP000002702334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LAMA5O152303, ENSP000002529994I2D: score=3 STRING: ENSP00000252999
    EPB41P111713, ENSP000002901004I2D: score=2 STRING: ENSP00000290100
    BCAT2ENSP000003229914STRING: ENSP00000322991
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS7954395
    GO:0007160cell-matrix adhesion IMP16236823
    GO:0007165signal transduction TAS7777537

    Find genes that share ontologies with BCAM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for BCAM



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BCAM gene (2 alternative transcripts): 
    NM_001013257.2  NM_005581.4  

    Unigene Cluster for BCAM:

    Basal cell adhesion molecule (Lutheran blood group)
    Hs.625725  [show with all ESTs]
    Unigene Representative Sequence: NM_001013257
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589651 ENST00000270233(uc002ozu.3) ENST00000588303 ENST00000591520
    ENST00000588603 ENST00000590108 ENST00000590196 ENST00000589558 ENST00000588714
    ENST00000590624
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    Selected qRT-PCR Assays for microRNAs that regulate BCAM (see all 24):
    hsa-miR-26a-2* hsa-miR-1321 hsa-miR-3125 hsa-miR-3916 hsa-miR-4314 hsa-miR-661 hsa-miR-637 hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidBCAM 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat BCAM

    Additional mRNA sequence: 

    BC036745.1 BC050450.1 BC128254.1 HE572749.1 X80026.1 X83425.1 

    18 DOTS entries:

    DT.450799  DT.95290922  DT.95228681  DT.100756826  DT.91907749  DT.95138373  DT.100029416  DT.436336 
    DT.92425637  DT.97775394  DT.100758289  DT.121502442  DT.40286229  DT.95108934  DT.40116159  DT.91760413 
    DT.95334997  DT.99962805 

    Selected AceView cDNA sequences (see all 406):

    BE712979 BE712863 BX403419 X83425 BU101548 BI963871 BF445784 BE712869 
    BI835471 AI499132 BE712909 BM721688 BE712985 BF876484 AI364586 BF876889 
    BQ721579 BE712921 AA290786 BI761966 BQ879357 AA433977 BX110850 AA410602 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BCAM (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
    SP1:                                -                 -                                         -                 -     -               
    SP2:              -                 -                                                                                                   
    SP3:                                                  -     -                                                                           
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for BCAM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BCAM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCGCCCCCG
    BCAM Expression
    About this image


    BCAM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)
             Mature brain microvascular endothelial cells
     
     Brain (Nervous System)
             Mature brain microvascular endothelial cells
     
     Kidney (Urinary System)
    BCAM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BCAM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.625725

    UniProtKB/Swiss-Prot: BCAM_HUMAN, P50895
    Tissue specificity: Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated
    with the basal layer of cells in epithelia and the endothelium of blood vessel walls

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BCAM gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bcam1 , 5 basal cell adhesion molecule1, 5 75.68(n)1
    73.43(a)1
      7 (9.94 cM)5
    572781  NM_020486.21  NP_065232.11 
     197561315 
    lizard
    (Anolis carolinensis)
    Reptilia BCAM6
    basal cell adhesion molecule (Lutheran blood group...
    34(a)
    1 ↔ 1
    GL344091.1(1862-79860)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bcam1 basal cell adhesion molecule (Lutheran blood group) 47.16(n)
    37.43(a)
      100036718  XM_002941038.2  XP_002941084.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005366981 basal cell adhesion molecule-like 49.38(n)
    38.62(a)
      100536698  XM_003201703.2  XP_003201751.2 


    ENSEMBL Gene Tree for BCAM (if available)
    TreeFam Gene Tree for BCAM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BCAM gene
    MCAM2  ALCAM2  
    1 SIMAP similar gene for BCAM using alignment to 3 protein entries:     BCAM_HUMAN (see all proteins):
    LU

    Find genes that share paralogs with BCAM           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    BCAM_HUMAN, P50895: BCAM is responsible for the Lutheran blood group system (LU) [MIM:111200]. Lutheran is a complex
    blood group system consisting of 19 antigens. Antigens Lu(a) and Lu(b) are defined by a polymorphism at position
    77: Lu(a) has His-77 and Lu(b) has Arg-77
    BCAM_HUMAN, P50895: Inactivating variants in BCAM are responsible for the recessive Lutheran null phenotype Lu(a-b-) of
    the Lutheran blood group [MIM:247420]. Autosomal recessive inheritance of the Lutheran null blood group phenotype
    is extremely rare. There is no obvious associated clinical or hematologic pathology, and all patients have been
    identified through identification of anti-Lu3 antibodies in their serum


    Selected SNPs for BCAM (see all 514)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs283996531,2,,4
    C,Fnon-pathogenic145505361(+) CCCCCG/ACCTAG 4 /H /R mis1 ese312Minor allele frequency- A:0.03NS NA EU 3042
    rs11350621,2,,4
    C,F,Hnon-pathogenic145512660(+) TCGGCA/GCCGGT 4 T A mis139Minor allele frequency- G:0.30NA NS EA CSA WA EU 8808
    rs38101411,2
    C,Fpathogenic145506720(-) GCGGCA/G/TCAGTG 4 * C stg1 ese37NS NA WA EU 5729
    rs283995981,2
    C,F--45311924(+) GCTTG-/GGGGGCC 2 -- us2k12Minor allele frequency- GG:0.04NS 94
    rs287395881,2
    C,F--45319297(+) AGGCCG/AGGCCC 2 -- int14Minor allele frequency- A:0.03NS NA 214
    rs1115487061,2
    C,F--45320386(+) GTACTT/CGGGAG 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs283996391,2
    C--45324564(+) CCCCC-/CTCACC 2 -- ut31 trp32Minor allele frequency- C:0.01NS 94
    rs29651611,2
    C,F,A--45500235(-) CCATCG/CCCCAC 2 -- us2k17Minor allele frequency- C:0.10NA NS CSA WA EA 338
    rs1384152701,2
    C--45500659(+) CCAGA-/GGGGGA 2 -- us2k10--------
    rs1870074751,2
    --45500999(+) GATTGC/TGCCCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for BCAM (45312328 - 45324678 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for BCAM:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3947n71CNV Loss21882294
    nsv912123CNV Loss21882294
    nsv912124CNV Loss21882294
    nsv912121CNV Loss21882294
    dgv3945n71CNV Gain21882294
    dgv3946n71CNV Gain21882294
    nsv912127CNV Gain21882294
    nsv912126CNV Gain+Loss21882294

    Human Gene Mutation Database (HGMD): BCAM
    Locus Specific Mutation Databases (LSDB): BCAM

    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BCAM
    DNA2.0 Custom Variant and Variant Library Synthesis for BCAM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 612773   
    OMIM disorders: 111200  247420  
    3 diseases for BCAM:    
    About MalaCards
    testicular gonadoblastoma    sickle cell disease    gonadoblastoma

    1 disease from the University of Copenhagen DISEASES database for BCAM:
    Testicular gonadoblastoma

    Find genes that share disorders with BCAM           About GenesLikeMe

    7 Novoseek inferred disease relationships for BCAM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma basal cell 47.5 3 10728810 (1), 15278364 (1), 11121140 (1)
    erythroleukemia 47.2 1 10630290 (1)
    skin tumor 44.9 3 11121140 (2), 15278364 (1)
    colon carcinoma 33.4 1 10542217 (1)
    carcinoma squamous cell 18.4 2 15278364 (1), 11121140 (1)
    cancer 9.22 3 16584446 (1), 7954395 (1), 10542217 (1)
    tumors 0 10 11121140 (3), 15278364 (2), 16584446 (1), 15923364 (1)

    Genetic Association Database (GAD): BCAM
    Human Genome Epidemiology (HuGE) Navigator: BCAM (6 documents)

    Export disorders for BCAM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for BCAM gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with BCAM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism. (PubMed id 9192786)1, 2, 9 El Nemer W....Le Van Kim C. (Blood 1997)
    2. Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily. (PubMed id 7954395)1, 2, 9 Campbell I.G....Rettig W.J. (Cancer Res. 1994)
    3. Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms. (PubMed id 9166867)1, 2, 9 Parsons S.F....Anstee D.J. (Blood 1997)
    4. Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data. (PubMed id 20370913)1, 4 Ma L....Da Y. (BMC Med. Genet. 2010)
    5. Polymorphic analysis of the Lutheran blood group system in Chinese. (PubMed id 19201739)1, 4 Zeng J.Q....Yu Q. (Ann. Clin. Lab. Sci. 2009)
    6. [Study on the gene polymorphism of Auberger antigens in Chinese population]. (PubMed id 19065527)1, 4 Zeng J....Yu Q. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)
    7. Introduction of a real-time-based blood-group genotyping approach. (PubMed id 18510579)1, 4 Polin H....Gabriel C. (Vox Sang. 2008)
    8. The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3. (PubMed id 17638854)1, 2 Mankelow T.J.... Anstee D.J. (Blood 2007)
    9. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4059 HGNC: 6722 AceView: LU Ensembl:ENSG00000187244 euGenes: HUgn4059
    ECgene: BCAM H-InvDB: BCAM

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BCAM Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=lutheran
    SeattleSNPshttp://pga.gs.washington.edu/data/lu/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BCAM gene:
    Search GeneIP for patents involving BCAM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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