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Aliases for BCAM Gene

Aliases for BCAM Gene

  • Basal Cell Adhesion Molecule (Lutheran Blood Group) 2 3
  • LU 3 4 6
  • Basal Cell Adhesion Molecule (Lu And Au Blood Groups) 2 3
  • B-CAM Cell Surface Glycoprotein 3 4
  • Auberger B Antigen 3 4
  • F8/G253 Antigen 3 4
  • MSK19 3 4
  • Lutheran Blood Group (Auberger B Antigen Included) 2
  • Antigen Identified By Monoclonal Antibody F8 3
  • Lutheran Blood Group Glycoprotein 4
  • Basal Cell Adhesion Molecule 3
  • B-Cell Adhesion Molecule 3
  • Glycoprotein 95kDa 3
  • Lutheran Antigen 4
  • CD239 Antigen 4
  • CD239 3
  • AU, 6
  • AU 3

External Ids for BCAM Gene

Previous HGNC Symbols for BCAM Gene

  • LU

Previous GeneCards Identifiers for BCAM Gene

  • GC19P050005
  • GC19P045312
  • GC19P041744

Summaries for BCAM Gene

Entrez Gene Summary for BCAM Gene

  • This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for BCAM Gene

BCAM (Basal Cell Adhesion Molecule (Lutheran Blood Group)) is a Protein Coding gene. Diseases associated with BCAM include testicular gonadoblastoma and sickle cell disease. GO annotations related to this gene include transmembrane signaling receptor activity and laminin receptor activity. An important paralog of this gene is ALCAM.

UniProtKB/Swiss-Prot for BCAM Gene

  • Laminin alpha-5 receptor. May mediate intracellular signaling.

Gene Wiki entry for BCAM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAM Gene

Genomics for BCAM Gene

Regulatory Elements for BCAM Gene

Genomic Location for BCAM Gene

44,809,059 bp from pter
44,821,421 bp from pter
12,363 bases
Plus strand

Genomic View for BCAM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAM Gene

Proteins for BCAM Gene

  • Protein details for BCAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Basal cell adhesion molecule
    Protein Accession:
    Secondary Accessions:
    • A8MYF9
    • A9YWT5
    • A9YWT6
    • Q86VC7

    Protein attributes for BCAM Gene

    628 amino acids
    Molecular mass:
    67405 Da
    Quaternary structure:
    No Data Available
    • Sequence=EAW57297.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCAM Gene

neXtProt entry for BCAM Gene

Proteomics data for BCAM Gene at MOPED

Post-translational modifications for BCAM Gene

  • Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin.
  • Glycosylation at Asn321, Asn377, Asn383, Asn419, and Asn439
  • Modification sites at PhosphoSitePlus

Other Protein References for BCAM Gene

Antibody Products

No data available for DME Specific Peptides for BCAM Gene

Domains for BCAM Gene

Gene Families for BCAM Gene

  • C2SET :Immunoglobulin superfamily / C2-set domain containing
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • bloodgroup :Blood group antigens

Suggested Antigen Peptide Sequences for BCAM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P50895
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with BCAM: view

Function for BCAM Gene

Molecular function for BCAM Gene

UniProtKB/Swiss-Prot Function:
Laminin alpha-5 receptor. May mediate intracellular signaling.

Gene Ontology (GO) - Molecular Function for BCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 7777537
GO:0005055 laminin receptor activity IMP 16236823
GO:0005515 protein binding IPI 25416956
GO:0008022 protein C-terminus binding IDA 24453976
GO:0043236 laminin binding IMP 16236823
genes like me logo Genes that share ontologies with BCAM: view
genes like me logo Genes that share phenotypes with BCAM: view

Animal Models for BCAM Gene

MGI Knock Outs for BCAM:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCAM

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for BCAM Gene

Localization for BCAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCAM Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for BCAM Gene COMPARTMENTS Subcellular localization image for BCAM gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 9166867
GO:0005887 integral component of plasma membrane TAS 7777537
GO:0009897 external side of plasma membrane IC 16236823
GO:0009986 cell surface --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with BCAM: view

Pathways for BCAM Gene

SuperPathways for BCAM Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 7954395
GO:0007160 cell-matrix adhesion IMP 16236823
GO:0007165 signal transduction TAS 7777537
genes like me logo Genes that share ontologies with BCAM: view

No data available for Pathways by source for BCAM Gene

Transcripts for BCAM Gene

Unigene Clusters for BCAM Gene

Basal cell adhesion molecule (Lutheran blood group):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCAM

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCAM Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: - - - - -
SP2: - -
SP3: - -

Relevant External Links for BCAM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCAM Gene

mRNA expression in normal human tissues for BCAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCAM Gene

This gene is overexpressed in Kidney - Cortex (5.3) and Artery - Tibial (5.0).

Protein differential expression in normal tissues for BCAM Gene

This gene is overexpressed in Lung (12.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCAM Gene

SOURCE GeneReport for Unigene cluster for BCAM Gene Hs.625725

mRNA Expression by UniProt/SwissProt for BCAM Gene

Tissue specificity: Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls
genes like me logo Genes that share expressions with BCAM: view

Expression partners for BCAM Gene

In Situ Assay Products

Orthologs for BCAM Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCAM Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BCAM 35
  • 82.27 (n)
  • 77.39 (a)
  • 77 (a)
(Canis familiaris)
Mammalia BCAM 35
  • 84.18 (n)
  • 80.41 (a)
  • 80 (a)
(Mus musculus)
Mammalia Bcam 35
  • 75.68 (n)
  • 73.43 (a)
Bcam 16
Bcam 36
  • 71 (a)
(Pan troglodytes)
Mammalia BCAM 35
  • 99.38 (n)
  • 98.96 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Bcam 35
  • 76.26 (n)
  • 73.63 (a)
(Ornithorhynchus anatinus)
Mammalia BCAM 36
  • 48 (a)
(Anolis carolinensis)
Reptilia BCAM 36
  • 34 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bcam 35
  • 47.16 (n)
  • 37.43 (a)
(Danio rerio)
Actinopterygii LOC100536698 35
  • 49.38 (n)
  • 38.62 (a)
bcam 36
  • 30 (a)
BCAM (1 of 2) 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
Species with no ortholog for BCAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCAM Gene

Gene Tree for BCAM (if available)
Gene Tree for BCAM (if available)

Paralogs for BCAM Gene

Paralogs for BCAM Gene

Selected SIMAP similar genes for BCAM Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BCAM: view

Variants for BCAM Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for BCAM Gene

BCAM is responsible for the Lutheran blood group system (LU) [MIM:111200]. Lutheran is a complex blood group system consisting of 19 antigens. Antigens Lu(a) and Lu(b) are defined by a polymorphism at position 77: Lu(a) has His-77 and Lu(b) has Arg-77

Sequence variations from dbSNP and Humsavar for BCAM Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3669 -- 44,819,816(+) ACATC(C/T)TATCC utr-variant-3-prime, intron-variant
rs7026 -- 44,821,259(+) CTCCC(C/T)TGCTG utr-variant-3-prime
rs922385 -- 44,812,075(-) gctcc(G/T)tgctc intron-variant
rs922387 -- 44,808,857(-) ACCAG(C/T)GTAGC upstream-variant-2KB
rs936517 -- 44,813,151(-) CCGGG(A/C)TCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCAM Gene

Variant ID Type Subtype PubMed ID
dgv3945n71 CNV Gain 21882294
dgv3946n71 CNV Gain 21882294
nsv912121 CNV Loss 21882294
nsv912123 CNV Loss 21882294
nsv912124 CNV Loss 21882294
dgv3947n71 CNV Loss 21882294
nsv912126 CNV Gain+Loss 21882294
nsv912127 CNV Gain 21882294

Relevant External Links for BCAM Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group

Disorders for BCAM Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BCAM Gene in MalaCards »

(3) Diseases for BCAM Gene including...

(2) OMIM Diseases for BCAM Gene (612773)

(1) University of Copenhagen DISEASES for BCAM Gene

(7) Novoseek inferred disease relationships for BCAM Gene

Disease -log(P) Hits PubMed IDs
carcinoma basal cell 47.5 3
erythroleukemia 47.2 1
skin tumor 44.9 3
colon carcinoma 33.4 1
carcinoma squamous cell 18.4 2

Relevant External Links for BCAM

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BCAM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCAM Gene

Publications for BCAM Gene

  1. Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms. (PMID: 9166867) Parsons S.F. … Anstee D.J. (Blood 1997) 3 4 23
  2. Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism. (PMID: 9192786) El Nemer W. … Le Van Kim C. (Blood 1997) 3 4 23
  3. Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily. (PMID: 7954395) Campbell I.G. … Rettig W.J. (Cancer Res. 1994) 3 4 23
  4. Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity. (PMID: 11133776) Parsons S.F. … Chasis J.A. (Blood 2001) 3 23
  5. Characterization of the laminin binding domains of the Lutheran blood group glycoprotein. (PMID: 11319237) El Nemer W. … Van Kim C.L. (J. Biol. Chem. 2001) 3 23

Products for BCAM Gene

Sources for BCAM Gene

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