BCAM Gene

Aliases
for BCAM gene

Previous GC identifers: GC19P050005 GC19P041744

Summaries
for BCAM gene

Genomic Views
for BCAM gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmids (see all 2): BCAM promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCAM

BCAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045312:  view genomic region     (about GC identifiers)

Proteins
for BCAM gene

2 PDB 3D structures from and Proteopedia for BCAM:

2PET (3D)        2PF6 (3D)    

Explore the universe of human proteins at neXtProt for BCAM: NX_P50895

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for BCAM
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: BCAM OriGene Protein Over-expression Lysate: BCAM OriGene Custom Protein Services for BCAM
	GenScript Custom Purified and Recombinant Proteins Services for BCAM
	Novus Biologicals BCAM Protein Novus Biologicals BCAM Lysate
	Sino Biological Recombinant Protein for BCAM
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for BCAM

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

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	R&D Systems Antibodies for BCAM
	OriGene Antibodies (see all 2): BCAM OriGene Custom Antibody Services for BCAM
	GenScript Custom Superior Antibodies Services for BCAM
	Novus Biologicals BCAM Antibodies
	Abcam antibodies for BCAM
	Uscn Antibodies for BCAM
	Search ThermoFisher Antibodies for BCAM

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for BCAM         (see all)
	GenScript Custom Assay Services for BCAM
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for BCAM

Protein Domains /
Families
for BCAM gene

ProtoNet protein and cluster: P50895

Function
for BCAM gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): BCAM Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BCAM
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate BCAM (see all 24):
		hsa-miR-26a-2* hsa-miR-1321 hsa-miR-3125 hsa-miR-3916 hsa-miR-4314 hsa-miR-661 hsa-miR-637 hsa-miR-508-5p
		SwitchGear 3'UTR luciferase reporter plasmid: BCAM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BCAM (see all 7) OriGene shRNA RFP: BCAM OriGene siRNA: BCAM
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BCAM

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for BCAM

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BCAM (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BCAM (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): BCAM (NM_005581)
		Sino Biological Human cDNA Clone for BCAM
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BCAM
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BCAM

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BCAM
		Search LifeMap BioReagents cell lines for BCAM

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAM

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Bcam)

Pathways & Interactions
for BCAM gene

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for BCAM gene

Transcripts
for BCAM gene

Expression
for BCAM gene

BCAM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCGCCCCCG

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Mature brain microvascular endothelial cells (Derivation of blood-...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BCAM Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BCAM
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BCAM
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BCAM

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCAM

Orthologs
for BCAM gene

Paralogs
for BCAM gene

Paralogs for BCAM gene

MCAM²  AGER²  ALCAM²  

1 SIMAP similar gene for BCAM using alignment to 3 protein entries:     BCAM_HUMAN (see all proteins):

LU

BCAM for paralogs           About GeneDecksing

Genomic Variants
for BCAM gene

10/383 NCBI SNPs in BCAM are shown (see all 383)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs283996531,2	C,F,	non-pathogenic	41746575(+)	CCCCCG/ACCTAG	4	/H /R	mis1 ese3		12		NS NA EU	3042
rs11350621,2	C,F,H,	non-pathogenic	41753852(+)	TCGGCA/GCCGGT	4	T A	mis1		39		NA NS EA CSA WA EU	8808
rs38101411,2	C,F,	pathogenic	41747934(-)	GCGGCA/G/TCAGTG	6	* C	stg1 syn1 ese3		7		NS NA WA EU	5729
rs29651611,2	C,F,A,	--	41741449(-)	CCATCG/CCCCAC	2	--	us2k1		7		NA NS CSA WA EA	338
rs730482581,2	C,F,	--	41742274(+)	ACAAAC/AAAAAA	2	--	us2k1		1		NA	120
rs790604561,2		--	41742402(+)	AGGGCA/TACCTC	2	--	us2k1		0	--	--	--	--
rs29274781,2	C,F,A,H,	--	41742653(-)	GGCCAG/AAGCAG	2	--	us2k1		20		NS EA NA CSA WA	2280
rs81131711,2	C,F,	--	41742877(+)	TAAGAG/CATTAA	2	--	us2k1		12		NS NA WA EA	1112
rs29676711,2	C,F,A,H,	--	41743166(+)	CGAGTC/GCCCAA	2	--	us2k1		12		NS EA NA CSA WA	754
rs124626301,2	H	--	41743295(+)	GACAGA/CTCTAG	2	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for BCAM (45312328 - 45324678 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for BCAM: --
Human Gene Mutation Database (HGMD): BCAM

Locus Specific Mutation Databases (LSDB): BCAM
Blood Group Antigen Gene Mutation Database (BGMUT) blood group system

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BCAM

DNA2.0 Custom Variant and Variant Library Synthesis for BCAM

Disorders / Diseases
for BCAM gene

9 diseases for BCAM

7 Novoseek disease relationships for BCAM gene    About this table

Publications
for BCAM gene

PubMed articles for BCAM gene, integrated from 9 sources (see all 63): (articles sorted by number of sources associating them with BCAM)

Utopia: connect your pdf to the dynamic world of online information

1. Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism. (PubMed id 9192786)^{1, 2, 9} El Nemer W....Le Van Kim C. (1997)
2. Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily. (PubMed id 7954395)^{1, 2, 9} Campbell I.G....Rettig W.J. (1994)
3. Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms. (PubMed id 9166867)^{1, 2, 9} Parsons S.F....Anstee D.J. (1997)
4. The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3. (PubMed id 17638854)^{1, 2} Mankelow T.J....Anstee D.J. (2007)
5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)^{1, 2} Zhang H.... Aebersold R. (2003)
8. The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver. (PubMed id 7777537)^{1, 2} Parsons S.F.... Anstee D.J. (1995)
9. A unique gene encodes spliceoforms of the B-cell adhesion molecule cell surface glycoprotein of epithelial cancer and of the Lutheran blood group glycoprotein. (PubMed id 8781446)^{1, 9} Rahuel C....Colin Y. (1996)
10. Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer. (PubMed id 15278364)^{1, 9} Drewniok C....Schon M.P. (2004)

External Searches for BCAM gene

Genome Databases showing BCAM gene

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Specialized Databases showing BCAM gene

Products
for BCAM gene