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BBX Gene

protein-coding   GIFtS: 50
GCID: GC03P107241

Bobby Sox Homolog (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bobby Sox Homolog (Drosophila)1 2     HSPC3392
X 001 Protein1 2     MDS0012
HBP22 3     Ag Recognized By Treg Cells 12
HMG Box-Containing Protein 22 3     HMG Box Transcription Factor BBX2
ARTC12     Bobby Sox Homolog3

External Ids:    HGNC: 144221   Entrez Gene: 569872   Ensembl: ENSG000001144397   UniProtKB: Q8WY363   

Export aliases for BBX gene to outside databases

Previous GC identifers: GC03P103845 GC03P106769 GC03P108523 GC03P108562 GC03P108724 GC03P104615


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BBX Gene:
BBX (bobby sox homolog (Drosophila)) is a protein-coding gene. Diseases associated with BBX include lymphocytic gastritis, and gastritis. An important paralog of this gene is CIC.

UniProtKB/Swiss-Prot: BBX_HUMAN, Q8WY36
Function: Transcription factor that is necessary for cell cycle progression from G1 to S phase

Gene Wiki entry for BBX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BBX gene promoter:
         E2F-3a   E2F-4   Oct-B1   E2F-5   oct-B2   E2F-2   SRY   E2F-1   E2F   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBBX promoter sequence
   Search Chromatin IP Primers for BBX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BBX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.1   Ensembl cytogenetic band:  3q13.12   HGNC cytogenetic band: 3q13.1

BBX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BBX gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P107241:  view genomic region     (about GC identifiers)

Start:
107,241,783 bp from pter      End:
107,530,171 bp from pter
Size:
288,389 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BBX_HUMAN, Q8WY36 (See protein sequence)
Recommended Name: HMG box transcription factor BBX  
Size: 941 amino acids; 105130 Da
Sequence caution: Sequence=AAI10904.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q2TAJ1 Q7L3J8 Q7LBY8 Q8NDB0 Q8WY35 Q9H0J6
Alternative splicing: 2 isoforms:  Q8WY36-1   Q8WY36-2   

Explore the universe of human proteins at neXtProt for BBX: NX_Q8WY36

Explore proteomics data for BBX at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BBX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001136040.1  NP_001263215.1  NP_064620.2  

    ENSEMBL proteins: 
     ENSP00000408358   ENSP00000385317   ENSP00000319974   ENSP00000413320   ENSP00000403860  
     ENSP00000396373   ENSP00000392230   ENSP00000408297   ENSP00000400543   ENSP00000404654  
     ENSP00000413274   ENSP00000385518   ENSP00000385530   ENSP00000403806   ENSP00000406554  
     ENSP00000412390   ENSP00000407662   ENSP00000404943   ENSP00000414673   ENSP00000402372  
     ENSP00000401524  

    BBX Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for BBX
    OriGene Custom MassSpec
    OriGene Custom Protein Services for BBX
    GenScript Custom Purified and Recombinant Proteins Services for BBX
    Novus Biologicals BBX Protein
    Novus Biologicals BBX Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BBX

    BBX Antibody Products:

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    Novus Biologicals BBX Antibodies
    Abcam antibodies for BBX (Q8WY36, A2RRM7)
    Cloud-Clone Corp. Antibodies for BBX
    Search ThermoFisher Antibodies for BBX
    LSBio Antibodies in human, mouse, rat for BBX

    BBX Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BBX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BBX
    Cloud-Clone Corp. CLIAs for BBX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR009071 HMG_box_dom
     IPR019102 TF_HMG_box_BBX_DUF2028

    Graphical View of Domain Structure for InterPro Entry Q8WY36

    ProtoNet protein and cluster: Q8WY36

    UniProtKB/Swiss-Prot: BBX_HUMAN, Q8WY36
    Similarity: Contains 1 HMG box DNA-binding domain


    BBX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BBX_HUMAN, Q8WY36
    Function: Transcription factor that is necessary for cell cycle progression from G1 to S phase

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    BBX for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bbx):
     cardiovascular system  cellular  craniofacial  growth/size/body  hematopoietic system 
     immune system  skeleton 

    BBX for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BBX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BBX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BBX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BBX

    miRNA
    Products:
        
    miRTarBase miRNAs that target BBX:
    hsa-mir-26a-5p (MIRT050155), hsa-mir-92a-3p (MIRT049573), hsa-mir-484 (MIRT042364), hsa-mir-92b-3p (MIRT040700), hsa-mir-335-5p (MIRT016947)

    Block miRNA regulation of human, mouse, rat BBX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BBX (see all 116):
    hsa-miR-106a hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93 hsa-miR-298 hsa-miR-2113 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidBBX 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BBX
    Predesigned siRNA for gene silencing in human, mouse, rat BBX

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for BBX

    Clone
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    OriGene clones in human, mouse for BBX (see all 13)
    OriGene ORF clones in mouse, rat for BBX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BBX (NM_020235)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BBX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BBX

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for BBX
    Browse ESI BIO Cell Lines and PureStem Progenitors for BBX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BBX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BBX_HUMAN, Q8WY36: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    chloroplast1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    BBX for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BBX
    Interactions:

        Search GeneGlobe Interaction Network for BBX

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for BBX (ENSP000003199744) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO2ENSP000004059654STRING: ENSP00000405965
    NFKBIAENSP000002167974STRING: ENSP00000216797
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0060348bone development IEA--

    BBX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BBX



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BBX gene (3 alternative transcripts): 
    NM_001142568.2  NM_001276286.1  NM_020235.6  

    Unigene Cluster for BBX:

    Bobby sox homolog (Drosophila)
    Hs.124366  [show with all ESTs]
    Unigene Representative Sequence: NM_001142568
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000415149(uc010hpr.3 uc003dwk.4 uc003dwl.4 uc003dwm.4 uc003dwo.4)
    ENST00000402543 ENST00000325805 ENST00000474137 ENST00000485939 ENST00000427402
    ENST00000416476 ENST00000454540 ENST00000431630 ENST00000449335 ENST00000456817
    ENST00000458458 ENST00000456419 ENST00000402163 ENST00000406780(uc010hps.1)
    ENST00000413213 ENST00000449271 ENST00000425868
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BBX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BBX (see all 116):
    hsa-miR-106a hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93 hsa-miR-298 hsa-miR-2113 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidBBX 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BBX
    Predesigned siRNA for gene silencing in human, mouse, rat BBX
    Clone
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    OriGene clones in human, mouse for BBX (see all 13)
    OriGene ORF clones in mouse, rat for BBX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BBX (NM_020235)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BBX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BBX
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for BBX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BBX
      QuantiTect SYBR Green Assays in human, mouse, rat BBX
      QuantiFast Probe-based Assays in human, mouse, rat BBX

    Additional mRNA sequence: 

    AF052174.1 AF161457.1 AF168718.1 AF276948.1 AF276949.1 AF283775.2 AF454941.1 AF454942.1 
    AK025944.1 AK026082.1 AK057010.1 AK130627.1 AK291757.1 AK307668.1 AK314434.1 AL136769.1 
    AL834307.1 AY527413.1 BC012837.1 BC110903.1 BC131718.1 

    18 DOTS entries:

    DT.95198155  DT.448789  DT.445965  DT.97859057  DT.97809187  DT.101982460  DT.101955606  DT.91749119 
    DT.99936899  DT.214889  DT.75112285  DT.92438454  DT.95198150  DT.120907155  DT.120907175  DT.86858826 
    DT.91650632  DT.92438444 

    Selected AceView cDNA sequences (see all 378):

    AI479510 AK057010 AI475419 BE670770 H89112 BF941693 NM_020235 BU154965 
    AA993671 AA349050 AL834307 CA439590 BE878574 BP337148 BM464277 AV725266 
    AI635689 BQ775790 AI075868 H99053 H88496 AA258231 CB123872 CA334817 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BBX    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                    -                                                                                                               
    SP2:                                                                                                                                    
    SP3:                                                                                                        -                           
    SP4:                                                                                                                                    


    ECgene alternative splicing isoforms for BBX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BBX expression in normal human tissues (normalized intensities)      BBX embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAAAGTACT
    BBX Expression
    About this image


    BBX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
    BBX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BBX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.124366
        Custom PCR Arrays for BBX
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for BBX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BBX
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    QuantiFast Probe-based Assays in human, mouse, rat BBX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BBX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BBX gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bbx1 , 5 bobby sox homolog (Drosophila)1, 5 88.31(n)1
    87.98(a)1
      16 (31.35 cM)5
    705081  NM_027444.31  NP_081720.21 
     501918445 
    chicken
    (Gallus gallus)
    Aves BBX1 bobby sox homolog (Drosophila) 75.51(n)
    73.7(a)
      418407  XM_004938284.1  XP_004938341.1 
    lizard
    (Anolis carolinensis)
    Reptilia BBX6
    bobby sox homolog (Drosophila)
    60(a)
    1 ↔ 1
    3(169769084-169923636)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043817.12   -- 76.62(n)    BC043817.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000055401 HMG box transcription factor BBX-like 60.52(n)
    60.47(a)
      100005540  XM_005172698.1  XP_005172755.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bbx6
    cic6
    capicua
    8(a)
    6(a)
    many ↔ many
    many ↔ many
    X(21234055-21244175)
    3R(16078492-16128194)
    worm
    (Caenorhabditis elegans)
    Secernentea gei-36
    Protein GEI-3, isoform a
    8(a)
    1 → many
    X(12795216-12813947) WBGene00001560


    ENSEMBL Gene Tree for BBX (if available)
    TreeFam Gene Tree for BBX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BBX gene
    CIC2  
    3 SIMAP similar genes for BBX using alignment to 20 protein entries:     BBX_HUMAN (see all proteins):
    CIC    SRY    soxB

    BBX for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BBX (see all 4941)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs622633431,2
    C,F--107239783(+) GCTGGG/AATTAC 3 -- us2k12Minor allele frequency- A:0.22NA 122
    rs788606031,2
    C--107239840(+) CGGGGG/TTTTCA 3 -- us2k10--------
    rs6948531,2
    C,F,A--107239867(-) agttcG/Aagacc 3 -- us2k13Minor allele frequency- A:0.50NA 6
    rs1831069601,2
    --107240161(+) AGCTTA/CCTCGG 3 -- us2k10--------
    rs2016473171,2
    --107240230(+) TCACG-/CCATTG 3 -- us2k10--------
    rs1874016571,2
    --107240240(+) GAACTC/TCAGCC 3 -- us2k10--------
    rs1408135141,2
    C--107240299(+) TTTTT-/TATATA 3 -- us2k10--------
    rs560918291,2
    C,F--107240451(+) CATACA/GCTCTT 3 -- us2k12Minor allele frequency- G:0.02WA 120
    rs1923312811,2
    C--107240502(+) CATCAA/GGGAAA 3 -- us2k10--------
    rs1836506531,2
    --107240908(+) CTGTCC/TCATAT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for BBX (107241783 - 107491783 bp, first 250kb of BBX)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for BBX:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656585CNV Deletion23128226
    esv2673634CNV Deletion23128226
    esv2670666CNV Deletion23128226
    esv27545CNV Loss19812545
    nsv877321CNV Loss21882294
    nsv829655CNV Gain17160897
    nsv829654CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for BBX:    About MalaCards
    lymphocytic gastritis    gastritis

    1 disease from the University of Copenhagen DISEASES database for BBX:
    Lymphocytic gastritis

    BBX for disorders           About GeneDecksing

    Genetic Association Database (GAD): BBX
    Human Genome Epidemiology (HuGE) Navigator: BBX (1 document)

    Export disorders for BBX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BBX gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with BBX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex. (PubMed id 11680820)1, 2, 3 Sanchez-Diaz A.... Moreno S. (Curr. Genet. 2001)
    2. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PubMed id 19247474)1, 4 Caporaso N....Bergen A.W. (PLoS ONE 2009)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    7. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56987 HGNC: 14422 AceView: BBX Ensembl:ENSG00000114439 euGenes: HUgn56987
    ECgene: BBX H-InvDB: BBX

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BBX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BBX gene:
    Search GeneIP for patents involving BBX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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