Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BAZ2A Gene

Aliases for BAZ2A Gene

  • Bromodomain Adjacent To Zinc Finger Domain, 2A 2 3
  • Transcription Termination Factor I-Interacting Protein 5 3 4
  • TTF-I Interacting Peptide 5 2 3
  • TTF-I-Interacting Protein 5 3 4
  • TIP5 3 4
  • Bromodomain Adjacent To Zinc Finger Domain Protein 2A 3
  • KIAA0314 4
  • HWALp3 4
  • WALp3 3

External Ids for BAZ2A Gene

Previous GeneCards Identifiers for BAZ2A Gene

  • GC12M056954
  • GC12M057214
  • GC12M056707
  • GC12M055275
  • GC12M054028

Summaries for BAZ2A Gene

GeneCards Summary for BAZ2A Gene

BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A) is a Protein Coding gene. GO annotations related to this gene include RNA binding and lysine-acetylated histone binding. An important paralog of this gene is KAT2A.

UniProtKB/Swiss-Prot for BAZ2A Gene

  • Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on Lys-16 (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).

Gene Wiki entry for BAZ2A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAZ2A Gene

Genomics for BAZ2A Gene

Regulatory Elements for BAZ2A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BAZ2A Gene

Start:
56,595,596 bp from pter
End:
56,636,816 bp from pter
Size:
41,221 bases
Orientation:
Minus strand

Genomic View for BAZ2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAZ2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAZ2A Gene

Proteins for BAZ2A Gene

  • Protein details for BAZ2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIF9-BAZ2A_HUMAN
    Recommended name:
    Bromodomain adjacent to zinc finger domain protein 2A
    Protein Accession:
    Q9UIF9
    Secondary Accessions:
    • B3KN66
    • O00536
    • O15030
    • Q68DI8
    • Q96H26

    Protein attributes for BAZ2A Gene

    Size:
    1905 amino acids
    Molecular mass:
    211198 Da
    Quaternary structure:
    • Component of the NoRC complex, at least composed of SMARCA5/SNF2H and BAZ2A/TIP5. Interacts with TTF1; required for recruitment of the NoRC complex to rDNA. Interacts with DNMT1, DNM3B, HDAC1 and SIN3A (By similarity).
    SequenceCaution:
    • Sequence=AAB60864.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAG51228.1; Type=Erroneous termination; Positions=168; Note=Translated as Tyr.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BAZ2A Gene

    Alternative splice isoforms for BAZ2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAZ2A Gene

Proteomics data for BAZ2A Gene at MOPED

Post-translational modifications for BAZ2A Gene

  • Acetylation at Lys-680 by KAT8/MOF promotes its dissociation from pRNA, affecting heterochromatin formation, nucleosome positioning and rDNA silencing. Deacetylation by SIRT1 in late S phase enhances pRNA-binding, allowing de novo DNA methylation and heterochromatin formation. Acetylation is high during S phase and declines to background levels in late S phase when the silent copies of rRNA genes are replicated (By similarity).
  • Ubiquitination at Lys1676
  • Modification sites at PhosphoSitePlus

Other Protein References for BAZ2A Gene

No data available for DME Specific Peptides for BAZ2A Gene

Domains for BAZ2A Gene

Gene Families for BAZ2A Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

Suggested Antigen Peptide Sequences for BAZ2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIF9

UniProtKB/Swiss-Prot:

BAZ2A_HUMAN :
  • Q9UIF9
Domain:
  • The bromo domain and the PHD-type zinc finger recognize and bind histone H4 acetylated on Lys-16 (H4K16ac). These 2 domains play a central role in the recritment of chromatin silencing proteins such as DNMT1, DNMT3B and HDAC1
  • The MBD (methyl-CpG-binding) domain, also named TAM domain, specifically recognizes and binds a conserved stem-loop structure the association within pRNA. Binding to pRNA induces a conformational change of BAZ2A/TIP5 and is essential for targeting the NoRC complex to the nucleolus (By similarity).
  • Contains 4 A.T hook DNA-binding domains.
  • Contains 1 bromo domain.
  • Contains 1 DDT domain.
  • Contains 1 MBD (methyl-CpG-binding) domain.
Family:
  • Belongs to the WAL family.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with BAZ2A: view

Function for BAZ2A Gene

Molecular function for BAZ2A Gene

GENATLAS Biochemistry: bromodomain adjacent to zinc finger domain,2A,expressed in brain,>100kDa,related to p300/CBP associated factor P (CAF)
UniProtKB/Swiss-Prot Function: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on Lys-16 (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).

Gene Ontology (GO) - Molecular Function for BAZ2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding ISS --
GO:0005515 protein binding IPI 17474147
GO:0008270 zinc ion binding IEA --
GO:0016922 ligand-dependent nuclear receptor binding NAS 10662543
genes like me logo Genes that share ontologies with BAZ2A: view

Phenotypes for BAZ2A Gene

GenomeRNAi human phenotypes for BAZ2A:
genes like me logo Genes that share phenotypes with BAZ2A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BAZ2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BAZ2A Gene

Localization for BAZ2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAZ2A Gene

Nucleus, nucleolus. Note=Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAZ2A Gene COMPARTMENTS Subcellular localization image for BAZ2A gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for BAZ2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005677 chromatin silencing complex ISS --
GO:0005730 nucleolus ISS --
GO:0033553 rDNA heterochromatin ISS --
genes like me logo Genes that share ontologies with BAZ2A: view

Pathways for BAZ2A Gene

SuperPathways for BAZ2A Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat

Gene Ontology (GO) - Biological Process for BAZ2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA ISS --
GO:0006306 DNA methylation ISS --
GO:0006338 chromatin remodeling NAS 11532953
GO:0006351 transcription, DNA-templated NAS 10662543
GO:0006355 regulation of transcription, DNA-templated NAS 10662543
genes like me logo Genes that share ontologies with BAZ2A: view

No data available for Pathways by source for BAZ2A Gene

Transcripts for BAZ2A Gene

Unigene Clusters for BAZ2A Gene

Bromodomain adjacent to zinc finger domain, 2A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BAZ2A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for BAZ2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAZ2A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^
SP1: - - - - -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b · 26c ^ 27a · 27b ^
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: - - - -
SP6: - -
SP7: -
SP8: -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 28a · 28b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for BAZ2A Gene

GeneLoc Exon Structure for
BAZ2A
ECgene alternative splicing isoforms for
BAZ2A

Expression for BAZ2A Gene

mRNA expression in normal human tissues for BAZ2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAZ2A Gene

SOURCE GeneReport for Unigene cluster for BAZ2A Gene Hs.314263

mRNA Expression by UniProt/SwissProt for BAZ2A Gene

Q9UIF9-BAZ2A_HUMAN
Tissue specificity: Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney and pancreas
genes like me logo Genes that share expressions with BAZ2A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BAZ2A Gene

Orthologs for BAZ2A Gene

This gene was present in the common ancestor of animals.

Orthologs for BAZ2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAZ2A 35
  • 99.45 (n)
  • 99.6 (a)
BAZ2A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAZ2A 35
  • 90.84 (n)
  • 91.61 (a)
BAZ2A 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAZ2A 35
  • 90.97 (n)
  • 91.94 (a)
BAZ2A 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Baz2a 35
  • 85.73 (n)
  • 84.84 (a)
Baz2a 16
Baz2a 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAZ2A 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Baz2a 35
  • 84.79 (n)
  • 82.9 (a)
chicken
(Gallus gallus)
Aves BAZ2A 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BAZ2A 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398712 35
tropical clawed frog
(Silurana tropicalis)
Amphibia baz2a 35
  • 56.29 (n)
  • 52.77 (a)
Str.1531 35
zebrafish
(Danio rerio)
Actinopterygii baz2a 36
  • 49 (a)
OneToOne
Dr.19658 35
fruit fly
(Drosophila melanogaster)
Insecta tou 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea flt-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for BAZ2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BAZ2A Gene

ENSEMBL:
Gene Tree for BAZ2A (if available)
TreeFam:
Gene Tree for BAZ2A (if available)

Paralogs for BAZ2A Gene

Paralogs for BAZ2A Gene

Selected SIMAP similar genes for BAZ2A Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for BAZ2A Gene

genes like me logo Genes that share paralogs with BAZ2A: view

Variants for BAZ2A Gene

Sequence variations from dbSNP and Humsavar for BAZ2A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs941207 -- 56,629,500(+) CCTAT(C/G)AACCT intron-variant
rs941210 -- 56,602,931(+) ATATC(A/G)GAGAA intron-variant
rs1064244 -- 56,597,278(-) CATTT(A/G)GTTGT utr-variant-3-prime
rs1107479 -- 56,636,902(-) TGCCT(A/G)TGACG upstream-variant-2KB
rs1465080 -- 56,616,896(+) TGAAC(C/T)TCTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BAZ2A Gene

Variant ID Type Subtype PubMed ID
nsv899106 CNV Gain 21882294
nsv820140 CNV Loss 19587683
nsv525202 CNV Loss 19592680
nsv438212 CNV Loss 16468122

Relevant External Links for BAZ2A Gene

HapMap Linkage Disequilibrium report
BAZ2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAZ2A Gene

Disorders for BAZ2A Gene

Relevant External Links for BAZ2A

Genetic Association Database (GAD)
BAZ2A
genes like me logo Genes that share disorders with BAZ2A: view

No data available for UniProtKB/Swiss-Prot for BAZ2A Gene

Publications for BAZ2A Gene

  1. A novel family of bromodomain genes. (PMID: 10662543) Jones M.H. … Shimane M. (Genomics 2000) 2 3 4
  2. NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines. (PMID: 11532953) Strohner R. … Grummt I. (EMBO J. 2001) 2 3
  3. The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription. (PMID: 12198165) Zhou Y. … Grummt I. (EMBO J. 2002) 3 23
  4. The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo. (PMID: 15292447) NAcmeth A. … LAongst G. (Nucleic Acids Res. 2004) 3 23
  5. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4

Products for BAZ2A Gene

Sources for BAZ2A Gene

Back to Top

Content