Aliases for BAZ2A Gene
External Ids for BAZ2A Gene
Previous GeneCards Identifiers for BAZ2A Gene
GeneCards Summary for BAZ2A Gene
BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A) is a Protein Coding gene. GO annotations related to this gene include RNA binding and lysine-acetylated histone binding. An important paralog of this gene is KAT2A.
UniProtKB/Swiss-Prot for BAZ2A Gene
Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on Lys-16 (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).