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BAZ2A Gene

protein-coding   GIFtS: 59
GCID: GC12M056954

Bromodomain Adjacent To Zinc Finger Domain, 2A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Bromodomain Adjacent To Zinc Finger Domain, 2A1 2     TTF-I-Interacting Protein 52 3
TTF-I Interacting Peptide 51 2     WALp32
Transcription Termination Factor I-Interacting Protein 52 3     Bromodomain Adjacent To Zinc Finger Domain Protein 2A2
TIP52 3     KIAA03143
hWALp32 3     Tip53

External Ids:    HGNC: 9621   Entrez Gene: 111762   Ensembl: ENSG000000761087   OMIM: 6056825   UniProtKB: Q9UIF93   
ORGUL members:         

Export aliases for BAZ2A gene to outside databases

Previous GC identifers: GC12M057214 GC12M056707 GC12M055275 GC12M054028


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BAZ2A Gene:
BAZ2A (bromodomain adjacent to zinc finger domain, 2A) is a protein-coding gene. GO annotations related to this gene include histone acetyl-lysine binding and RNA binding. An important paralog of this gene is BAZ1A.

UniProtKB/Swiss-Prot: BAZ2A_HUMAN, Q9UIF9
Function: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates
silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to
heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being
recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I
transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4
acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac.
Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter;
pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity)

Gene Wiki entry for BAZ2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BAZ2A gene promoter:
         MAZR   Sp1   Pax-5   STAT1beta   Ik-3   STAT1alpha   Evi-1   Gfi-1   C/EBPalpha   CHOP-10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BAZ2A promoter sequence
   Search Chromatin IP Primers for BAZ2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BAZ2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

BAZ2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAZ2A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M056954:  view genomic region     (about GC identifiers)

Start:
56,989,380 bp from pter      End:
57,030,600 bp from pter
Size:
41,221 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BAZ2A_HUMAN, Q9UIF9 (See protein sequence)
Recommended Name: Bromodomain adjacent to zinc finger domain protein 2A  
Size: 1905 amino acids; 211198 Da
Subunit: Component of the NoRC complex, at least composed of SMARCA5/SNF2H and BAZ2A/TIP5. Interacts with TTF1;
required for recruitment of the NoRC complex to rDNA. Interacts with DNMT1, DNM3B, HDAC1 and SIN3A (By
similarity)
Sequence caution: Sequence=AAB60864.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAG51228.1; Type=Erroneous termination; Positions=168; Note=Translated as Tyr;
1 PDB 3D structure from and Proteopedia for BAZ2A:
4LZ2 (3D)    
Secondary accessions: B3KN66 O00536 O15030 Q68DI8 Q96H26
Alternative splicing: 3 isoforms:  Q9UIF9-1   Q9UIF9-2   Q9UIF9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BAZ2A: NX_Q9UIF9

Explore proteomics data for BAZ2A at MOPED

Post-translational modifications: 

  • Acetylation at Lys-680 by KAT8/MOF promotes its dissociation from pRNA, affecting heterochromatin formation,
    nucleosome positioning and rDNA silencing. Deacetylation by SIRT1 in late S phase enhances pRNA-binding, allowing
    de novo DNA methylation and heterochromatin formation. Acetylation is high during S phase and declines to
    background levels in late S phase when the silent copies of rRNA genes are replicated (By similarity)1
  • Ubiquitination2 at Lys1676
  • Modification sites at PhosphoSitePlus

  • See BAZ2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_038477.2  
    ENSEMBL proteins: 
     ENSP00000368754   ENSP00000446880   ENSP00000448760   ENSP00000447941   ENSP00000447314  
     ENSP00000449473   ENSP00000447591   ENSP00000449496   ENSP00000447248   ENSP00000179765  
    Reactome Protein details: Q9UIF9

    BAZ2A Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for BAZ2A
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    Novus Biologicals BAZ2A Protein
    Novus Biologicals BAZ2A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BAZ2A

     
    Search eBioscience for Proteins for BAZ2A 

    BAZ2A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for BAZ2A
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    Search ThermoFisher Antibodies for BAZ2A
    LSBio Antibodies in human, mouse, rat for BAZ2A

    BAZ2A Assay Products:

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    Cloud-Clone Corp. ELISAs for BAZ2A
    Cloud-Clone Corp. CLIAs for BAZ2A
    Search eBioscience for ELISAs for BAZ2A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 12):
     IPR017956 AT_hook_DNA-bd_motif
     IPR001965 Znf_PHD
     IPR018501 DDT_dom_superfamily
     IPR013083 Znf_RING/FYVE/PHD
     IPR001739 Methyl_CpG_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9UIF9

    ProtoNet protein and cluster: Q9UIF9

    4 Blocks protein domains:
    IPB001487 Bromodomain signature
    IPB001739 Methyl-CpG binding
    IPB001965 Zn-finger-like
    IPB004022 DDT domain


    UniProtKB/Swiss-Prot: BAZ2A_HUMAN, Q9UIF9
    Domain: The bromo domain and the PHD-type zinc finger recognize and bind histone H4 acetylated on 'Lys-16'
    (H4K16ac). These 2 domains play a central role in the recritment of chromatin silencing proteins such as DNMT1,
    DNMT3B and HDAC1
    Domain: The MBD (methyl-CpG-binding) domain, also named TAM domain, specifically recognizes and binds a conserved
    stem-loop structure the association within pRNA. Binding to pRNA induces a conformational change of BAZ2A/TIP5
    and is essential for targeting the NoRC complex to the nucleolus (By similarity)
    Similarity: Belongs to the WAL family
    Similarity: Contains 4 A.T hook DNA-binding domains
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 DDT domain
    Similarity: Contains 1 MBD (methyl-CpG-binding) domain
    Similarity: Contains 1 PHD-type zinc finger


    Find genes that share domains with BAZ2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BAZ2A_HUMAN, Q9UIF9
    Function: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates
    silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to
    heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being
    recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I
    transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4
    acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac.
    Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter;
    pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity)

         Genatlas biochemistry entry for BAZ2A:
    bromodomain adjacent to zinc finger domain,2A,expressed in brain,>100kDa,related to p300/CBP associated factor P
    (CAF)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding ISS--
    GO:0005515protein binding IPI17474147
    GO:0008270zinc ion binding IEA--
    GO:0016922ligand-dependent nuclear receptor binding NAS10662543
         
    Find genes that share ontologies with BAZ2A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BAZ2A:
     Increased S DNA content  Lamellipodia cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BAZ2A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BAZ2A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BAZ2A

    miRNA
    Products:
        
    miRTarBase miRNAs that target BAZ2A:
    hsa-let-7a-5p (MIRT052394), hsa-mir-27b-3p (MIRT046228), hsa-mir-484 (MIRT042071), hsa-mir-425-5p (MIRT039339), hsa-mir-877-3p (MIRT037164), hsa-mir-671-5p (MIRT039284), hsa-mir-17-5p (MIRT051012), hsa-mir-328-3p (MIRT043809), hsa-mir-93-5p (MIRT048749), hsa-let-7b-5p (MIRT051904), hsa-mir-23a-3p (MIRT050400), hsa-mir-1180-3p (MIRT035918)

    Block miRNA regulation of human, mouse, rat BAZ2A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BAZ2A (see all 158):
    hsa-miR-194* hsa-miR-193a-3p hsa-miR-199a-3p hsa-miR-3921 hsa-miR-759 hsa-miR-1538 hsa-miR-3116 hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidBAZ2A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BAZ2A
    Predesigned siRNA for gene silencing in human, mouse, rat BAZ2A

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: BAZ2A (NM_013449)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BAZ2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAZ2A

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAZ2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BAZ2A_HUMAN, Q9UIF9: Nucleus, nucleolus (By similarity). Note=Colocalizes with the basal RNA polymerase I
    transcription factor UBF in the nucleolus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005677chromatin silencing complex ISS--
    GO:0005730nucleolus ISS--
    GO:0033553rDNA heterochromatin ISS--

    Find genes that share ontologies with BAZ2A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Find genes that share SuperPaths with BAZ2A           About GenesLikeMe

    Pathways by sourceSee SuperPaths
    Show all pathways


    1 Reactome Pathway for BAZ2A
        NoRC negatively regulates rRNA expression


        Pathway & Disease-focused RT2 Profiler PCR Array including BAZ2A: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BAZ2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BAZ2A (Q9UIF91, 2, 3 ENSP000003687544) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000183chromatin silencing at rDNA ISS--
    GO:0006306DNA methylation ISS--
    GO:0006338chromatin remodeling NAS11532953
    GO:0006351transcription, DNA-templated NAS10662543
    GO:0006355regulation of transcription, DNA-templated NAS10662543

    Find genes that share ontologies with BAZ2A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BAZ2A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BAZ2A gene: 
    NM_013449.3  

    Unigene Cluster for BAZ2A:

    Bromodomain adjacent to zinc finger domain, 2A
    Hs.314263  [show with all ESTs]
    Unigene Representative Sequence: NM_013449
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379441(uc001slo.1 uc009zov.1 uc009zow.1 uc001slp.1)
    ENST00000551812(uc010sqr.1) ENST00000549787 ENST00000549884 ENST00000553222
    ENST00000547453 ENST00000551759 ENST00000549763 ENST00000548578 ENST00000547650
    ENST00000551996 ENST00000549327 ENST00000547647 ENST00000551959 ENST00000546695
    ENST00000549506 ENST00000550730 ENST00000179765(uc001slq.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat BAZ2A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BAZ2A (see all 158):
    hsa-miR-194* hsa-miR-193a-3p hsa-miR-199a-3p hsa-miR-3921 hsa-miR-759 hsa-miR-1538 hsa-miR-3116 hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidBAZ2A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BAZ2A
    Clone
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    OriGene ORF clones in mouse, rat for BAZ2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BAZ2A (NM_013449)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BAZ2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAZ2A
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BAZ2A
      QuantiTect SYBR Green Assays in human, mouse, rat BAZ2A
      QuantiFast Probe-based Assays in human, mouse, rat BAZ2A

    Additional mRNA sequence: 

    AB002312.2 AF000422.1 AK023830.1 AK023842.1 AK127775.1 AK303327.1 BC008965.2 BC065914.1 
    CR749379.1 

    Selected DOTS entries (see all 26):

    DT.100661007  DT.95208438  DT.97862246  DT.95139532  DT.121178179  DT.92034330  DT.92042976  DT.97810162 
    DT.117346  DT.100672961  DT.70103562  DT.121178213  DT.92450913  DT.92450917  DT.95080922  DT.95139586 
    DT.95139588  DT.97815288  DT.121178174  DT.92450903  DT.92450920  DT.95139587  DT.97862248  DT.100661011 

    Selected AceView cDNA sequences (see all 347):

    AF000422 BQ641770 BQ023429 BU541076 AL044290 AW500107 CD671156 AL704059 
    AW516342 CB045090 BX476786 BE268989 AK023830 BQ688075 BQ066071 BX490963 
    BM457630 AW016810 AU185398 BE550724 AI804640 AW502018 BQ648984 AA653219 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BAZ2A (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^
    SP1:              -                                   -                                   -                                         -     -                     
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                          -           -                                                                     
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b · 26c ^ 27a · 27b ^
    SP1:                                      -                                                           -                             -                           
    SP2:                                      -                 -                                         -                             -                           
    SP3:                                      -           -                                               -                             -                           
    SP4:                                                                                                                                                            
    SP5:                                                                                                  -                 -     -     -                           

    ExUns: 28a · 28b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for BAZ2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BAZ2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATGTTCCA
    BAZ2A Expression
    About this image


    BAZ2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Kidney (Urinary System)
             Epithelial Tubule
     
     Testis (Reproductive System)
    BAZ2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BAZ2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.314263

    UniProtKB/Swiss-Prot: BAZ2A_HUMAN, Q9UIF9
    Tissue specificity: Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung,
    skeletal muscle, kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including BAZ2A: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BAZ2A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Baz2a1 , 5 bromodomain adjacent to zinc finger domain, 2A1, 5 85.73(n)1
    84.84(a)1
      10 (76.40 cM)5
    1168481  NM_054078.21  NP_473419.21 
     1280927835 
    chicken
    (Gallus gallus)
    Aves BAZ2A6
    bromodomain adjacent to zinc finger domain, 2A
    64(a)
    1 ↔ 1
    AADN03019662.1(600-5151)
    lizard
    (Anolis carolinensis)
    Reptilia BAZ2A6
    bromodomain adjacent to zinc finger domain, 2A
    60(a)
    1 ↔ 1
    2(92962518-93030784)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3987122 putative chromatin remodelling factor BAZ2A 72.64(n)    AY145834.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.196582 Transcribed sequence with weak similarity to protein more 77.37(n)    AL920125.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tou6
    toutatis
    15(a)
    1 → many
    2R(7464990-7503550)
    worm
    (Caenorhabditis elegans)
    Secernentea flt-16
    Protein FLT-1 (flt-1) mRNA, complete cds
    23(a)
    1 → many
    III(7650552-7656032) WBGene00001470


    ENSEMBL Gene Tree for BAZ2A (if available)
    TreeFam Gene Tree for BAZ2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BAZ2A gene
    BAZ1A2  BPTF2  BAZ2B2  CECR22  BAZ1B2  KAT2A2  KAT2B2  
    2 SIMAP similar genes for BAZ2A using alignment to 9 protein entries:     BAZ2A_HUMAN (see all proteins):
    BRDT    BAZ2B

    Find genes that share paralogs with BAZ2A           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for BAZ2A
    PGOHUM00000261818


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BAZ2A (see all 800)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1874269971,2
    --56990560(+) AAAAAA/GAATCT 1 -- ut310--------
    rs784709601,2
    C,F--56990746(+) GGCACC/TCCCAC 1 -- ut311Minor allele frequency- T:0.02NA 120
    rs1483996891,2
    C--56990981(+) CCCTCC/TTCCCT 1 -- ut310--------
    rs1891936341,2
    --56991010(+) GTCTCC/TGCTGC 1 -- ut310--------
    rs1816041691,2
    --56991022(+) GGGGAA/GGGGGT 1 -- ut310--------
    rs1857782741,2
    --56991041(+) ATGAAC/GTAAAT 1 -- ut310--------
    rs10642441,2
    C--56991062(-) CATTTA/GGTTGT 1 -- ut315Minor allele frequency- G:0.06MN NA EA 428
    rs1425275941,2
    C--56991131(+) CCGAGA/GAGAGA 1 -- ut310--------
    rs1902335461,2
    --56991216(+) TCTCCA/GGAGAA 1 -- ut310--------
    rs756484921,2
    C,F--56991323(+) CTATCA/GAACAA 1 -- ut312Minor allele frequency- G:0.04NA 122

    HapMap Linkage Disequilibrium report for BAZ2A (56989380 - 57030600 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BAZ2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525202CNV Loss19592680
    nsv438212CNV Loss16468122
    nsv820140CNV Loss19587683
    nsv899106CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605682    OMIM disorders: --


    Find genes that share disorders with BAZ2A           About GenesLikeMe

    Genetic Association Database (GAD): BAZ2A

    Export disorders for BAZ2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BAZ2A gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with BAZ2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel family of bromodomain genes. (PubMed id 10662543)1, 2, 3 Jones M.H.... Shimane M. (Genomics 2000)
    2. New gene functions in megakaryopoiesis and platelet formation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (Nature 2011)
    3. Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. (PubMed id 19578370)1, 2 Zhou Y.... Grummt I. (Nat. Cell Biol. 2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines. (PubMed id 11532953)1, 3 Strohner R....Grummt I. (EMBO J. 2001)
    8. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (DNA Res. 1997)
    9. The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo. (PubMed id 15292447)1, 9 NAcmeth A....LAongst G. (Nucleic Acids Res. 2004)
    10. The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription. (PubMed id 12198165)1, 9 Zhou Y....Grummt I. (EMBO J. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11176 HGNC: 962 AceView: BAZ2A Ensembl:ENSG00000076108 euGenes: HUgn11176
    ECgene: BAZ2A H-InvDB: BAZ2A

    (According to HUGE)
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    HUGE: KIAA0314

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BAZ2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BAZ2A gene:
    Search GeneIP for patents involving BAZ2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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