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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BAZ2A Gene

protein-coding GIFtS: 54
GCID: GC12M056954

bromodomain adjacent to zinc finger domain, 2A

Explore 1 disease affiliated with
BAZ2A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Bromodomain Adjacent To Zinc Finger Domain, 2A¹ ²		HWALp3¹
TIP5¹ ² ³		TTF-I-Interacting Protein 5² ³
WALp3¹ ²		Bromodomain Adjacent To Zinc Finger Domain Protein 2A²
KIAA0314¹ ³		TTF-I Interacting Peptide 5²
Transcription Termination Factor I-Interacting Protein 5² ³		Tip5³

External Ids:	HGNC: 962¹	Entrez Gene: 11176²	Ensembl: ENSG00000076108⁷	OMIM: 605682⁵	UniProtKB: Q9UIF9³

Export aliases for BAZ2A gene to outside databases

Previous GC identifers: GC12M057214 GC12M056707 GC12M055275 GC12M054028

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: BAZ2A_HUMAN, Q9UIF9

Function: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of

a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin

formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by

targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to

rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac),

leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs

that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and

rDNA silencing (By similarity)

Gene Wiki entry for BAZ2A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BAZ2A gene promoter:
MAZR Sp1 Pax-5 STAT1beta Ik-3 STAT1alpha Evi-1 Gfi-1 C/EBPalpha CHOP-10
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BAZ2A promoter sequence

Search SABiosciences Chromatin IP Primers for BAZ2A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAZ2A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.3

BAZ2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAZ2A gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M056954: view genomic region (about GC identifiers)

Start:	56,989,380 bp from pter	End:	57,030,600 bp from pter
Size:	41,221 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BAZ2A_HUMAN, Q9UIF9 (See protein sequence)

Recommended Name: Bromodomain adjacent to zinc finger domain protein 2A

Size: 1905 amino acids; 211198 Da

Subunit: Component of the NoRC complex, at least composed of SMARCA5/SNF2H and BAZ2A/TIP5. Interacts with TTF1;

required for recruitment of the NoRC complex to rDNA. Interacts with DNMT1, DNM3B, HDAC1 and SIN3A (By similarity)

Subcellular location: Nucleus, nucleolus (By similarity). Note=Colocalizes with the basal RNA polymerase I

transcription factor UBF in the nucleolus (By similarity)

Sequence caution: Sequence=AAB60864.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence; Sequence=BAG51228.1; Type=Erroneous termination; Positions=168; Note=Translated as Tyr;

Secondary accessions: B3KN66 O00536 O15030 Q68DI8 Q96H26

Alternative splicing: 3 isoforms: Q9UIF9-1 Q9UIF9-2 Q9UIF9-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BAZ2A: NX_Q9UIF9

Post-translational modifications:

Acetylation at Lys-680 by KAT8/MOF promotes its dissociation from pRNA, affecting heterochromatin formation, nucleosome

positioning and rDNA silencing. Deacetylation by SIRT1 in late S phase enhances pRNA-binding, allowing de novo DNA

methylation and heterochromatin formation. Acetylation is high during S phase and declines to background levels in

late S phase when the silent copies of rRNA genes are replicated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UIF9

BAZ2A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_038477.2

ENSEMBL proteins:

ENSP00000368754 ENSP00000446880 ENSP00000448760 ENSP00000447941 ENSP00000447314

ENSP00000449473 ENSP00000447591 ENSP00000449496 ENSP00000447248 ENSP00000179765

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	Novus Biologicals BAZ2A Protein Novus Biologicals BAZ2A Lysate
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	Uscn Proteins for BAZ2A

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005677	chromatin silencing complex	ISS	--
GO:0005730	nucleolus	ISS	--
GO:0016585	chromatin remodeling complex	--	--
GO:0033553	rDNA heterochromatin	ISS	--

BAZ2A for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for BAZ2A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BAZ2A for domains About GeneDecksing

5/12 InterPro domains/families (see all 12):

IPR017956 AT_hook_DNA-bd_motif

IPR004022 DDT_dom

IPR001965 Znf_PHD

IPR018359 Bromodomain_CS

IPR001487 Bromodomain

Graphical View of Domain Structure for InterPro Entry Q9UIF9

ProtoNet protein and cluster: Q9UIF9

4 Blocks protein families:

IPB001487 Bromodomain signature

IPB001739 Methyl-CpG binding

IPB001965 Zn-finger-like

IPB004022 DDT domain

UniProtKB/Swiss-Prot: BAZ2A_HUMAN, Q9UIF9

Domain: The bromo domain and the PHD-type zinc finger recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac).

These 2 domains play a central role in the recritment of chromatin silencing proteins such as DNMT1, DNMT3B and HDAC1

Domain: The MBD (methyl-CpG-binding) domain, also named TAM domain, specifically recognizes and binds a conserved

stem-loop structure the association within pRNA. Binding to pRNA induces a conformational change of BAZ2A/TIP5 and is

essential for targeting the NoRC complex to the nucleolus (By similarity)

Similarity: Belongs to the WAL family

Similarity: Contains 4 A.T hook DNA-binding domains

Similarity: Contains 1 bromo domain

Similarity: Contains 1 DDT domain

Similarity: Contains 1 MBD (methyl-CpG-binding) domain

Similarity: Contains 1 PHD-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BAZ2A_HUMAN, Q9UIF9

Function: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of

a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin

formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by

targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to

rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac),

leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs

that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and

rDNA silencing (By similarity)

Genatlas biochemistry entry for BAZ2A:

bromodomain adjacent to zinc finger domain,2A,expressed in brain,>100kDa,related to p300/CBP associated factor P (CAF)

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		hsa-miR-194* hsa-miR-193a-3p hsa-miR-199a-3p hsa-miR-3921 hsa-miR-759 hsa-miR-1538 hsa-miR-3116 hsa-miR-4326

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAZ2A

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003723	RNA binding	ISS	--
GO:0005515	protein binding	IPI	17474147
GO:0008270	zinc ion binding	IEA	--
GO:0016922	ligand-dependent nuclear receptor binding	NAS	10662543

BAZ2A for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for BAZ2A:

Increased S DNA content

Lamellipodia cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BAZ2A

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/37 Interacting proteins for BAZ2A (Q9UIF9^{1, 2, 3} ENSP00000368754⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³, ENSP00000352980⁴	I2D: score=1 STRING: ENSP00000352980
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000183	chromatin silencing at rDNA	ISS	--
GO:0006306	DNA methylation	ISS	--
GO:0006338	chromatin remodeling	NAS	11532953
GO:0006351	transcription, DNA-dependent	NAS	10662543
GO:0006355	regulation of transcription, DNA-dependent	NAS	10662543

BAZ2A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BAZ2A
Search CenterWatch for drugs/clinical trials and news about BAZ2A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BAZ2A gene:

NM_013449.3

Unigene Cluster for BAZ2A:

Bromodomain adjacent to zinc finger domain, 2A

Hs.314263 [show with all ESTs]

Unigene Representative Sequence: NM_013449

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379441(uc001slo.1 uc009zov.1 uc009zow.1 uc001slp.1)

ENST00000551812(uc010sqr.1) ENST00000549787 ENST00000549884 ENST00000553222

ENST00000547453 ENST00000551759 ENST00000549763 ENST00000548578 ENST00000547650

ENST00000551996 ENST00000549327 ENST00000547647 ENST00000551959 ENST00000546695

ENST00000549506 ENST00000550730 ENST00000179765(uc001slq.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BAZ2A
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		hsa-miR-194* hsa-miR-193a-3p hsa-miR-199a-3p hsa-miR-3921 hsa-miR-759 hsa-miR-1538 hsa-miR-3116 hsa-miR-4326

		SwitchGear 3'UTR luciferase reporter plasmid: BAZ2A 3' UTR sequence

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Additional cDNA sequence:

AB002312.2 AF000422.1 AK023830.1 AK023842.1 AK127775.1 AK303327.1 BC008965.2 BC065914.1

CR749379.1

24/26 DOTS entries (see all 26):

DT.100661007 DT.95208438 DT.97862246 DT.95139532 DT.121178179 DT.92034330 DT.92042976 DT.97810162

DT.117346 DT.100672961 DT.70103562 DT.121178213 DT.92450913 DT.92450917 DT.95080922 DT.95139586

DT.95139588 DT.97815288 DT.121178174 DT.92450903 DT.92450920 DT.95139587 DT.97862248 DT.100661011

24/347 AceView cDNA sequences (see all 347):

BU178855 AA634514 BQ220672 AI697712 AI247092 BE550724 BX476786 AW501836

BQ688075 BQ648984 BF796445 AW500107 BQ685054 BC008965 BQ023429 BX490963

AI214564 CD370182 BC065914 CD671156 BQ678184 AA576957 F11948 AU130034

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for BAZ2A (see all 16) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	·	12c	^	13a	·	13b	^	14a	·	14b	^	15a	·	15b	^
SP1:					-												-												-														-		-
SP2:
SP3:
SP4:																									-				-
SP5:

ExUns:	16a	·	16b	^	17	^	18	^	19a	·	19b	^	20a	·	20b	·	20c	^	21a	·	21b	^	22a	·	22b	^	23a	·	23b	·	23c	^	24a	·	24b	·	24c	^	25a	·	25b	^	26a	·	26b	·	26c	^	27a	·	27b	^
SP1:													-																				-										-
SP2:													-						-														-										-
SP3:													-				-																-										-
SP4:
SP5:																																	-						-		-		-

ExUns:	28a	·	28b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for BAZ2A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BAZ2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGATGTTCCA

About this image

BAZ2A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Epithelial Tubule

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

See BAZ2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BAZ2A

SOURCE GeneReport for Unigene cluster: Hs.314263

UniProtKB/Swiss-Prot: BAZ2A_HUMAN, Q9UIF9

Tissue specificity: Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung,

skeletal muscle, kidney and pancreas

SABiosciences Expression via Pathway-Focused PCR Array including BAZ2A:

Epigenetic Chromatin Remodeling Factors in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for BAZ2A gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	BAZ2A⁶	--	55(a)	1 ↔ 1	2(92996058-93030778)
African clawed frog (Xenopus laevis)	Amphibia	LOC398712²	putative chromatin remodelling factor BAZ2A	72.64(n)		AY145834.1
zebrafish (Danio rerio)	Actinopterygii	Dr.19658²	Transcribed sequence with weak similarity to protein more	77.37(n)		AL920125.1
fruit fly (Drosophila melanogaster)	Insecta	tou⁶	toutatis	11(a)	1 → many	2R(7464990-7503550)
worm (Caenorhabditis elegans)	Secernentea	flt-1⁶	FLecTin family member (flt-1)	18(a)	1 → many	III(7650487-7655967)

ENSEMBL Gene Tree for BAZ2A (if available)
TreeFam Gene Tree for BAZ2A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BAZ2A gene

BAZ1A² BPTF² BAZ2B² CECR2² BAZ1B² KAT2A² KAT2B²

2 SIMAP similar genes for BAZ2A using alignment to 9 protein entries: BAZ2A_HUMAN (see all proteins):

BRDT BAZ2B

BAZ2A for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for BAZ2A
PGOHUM00000261818

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187426997^1,2		--	56990560(+)	`AAAAAA/GAATCT`	1	--	ut3¹		0	--	--	--	--
rs78470960^1,2	C,F,	--	56990746(+)	`GGCACC/TCNNNN`	1	--	ut3¹		1		NA	120
rs148399689^1,2		--	56990981(+)	`CCCTCC/TTCCCT`	1	--	ut3¹		0	--	--	--	--
rs189193634^1,2		--	56991010(+)	`GTCTCC/TGCTGC`	1	--	ut3¹		0	--	--	--	--
rs181604169^1,2		--	56991022(+)	`GGGGAA/GGGGGT`	1	--	ut3¹		0	--	--	--	--
rs185778274^1,2		--	56991041(+)	`ATGAAC/GTAAAT`	1	--	ut3¹		0	--	--	--	--
rs1064244^1,2	C,	--	56991062(-)	`CATTTA/GGTTGT`	1	--	ut3¹		5		MN NA EA	428
rs142527594^1,2		--	56991131(+)	`CCGAGA/GAGAGA`	1	--	ut3¹		0	--	--	--	--
rs190233546^1,2		--	56991216(+)	`TCTCCA/GGAGAA`	1	--	ut3¹		0	--	--	--	--
rs75648492^1,2		--	56991323(+)	`CTATCA/GAACAA`	1	--	ut3¹		2		NA	122

HapMap Linkage Disequilibrium report for BAZ2A (56989380 - 57030600 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for BAZ2A
1 CNV: 1913
1 Indel: 58581

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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BAZ2A for disorders           About GeneDecksing

OMIM gene information: 605682    OMIM disorders: --

1 disease for BAZ2A:    About MalaCards

amenorrhea

Export disorders for BAZ2A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BAZ2A gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with BAZ2A)

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A novel family of bromodomain genes. (PubMed id 10662543)^{1, 2, 3} Jones M.H.... Shimane M. (2000)
Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. (PubMed id 19578370)^{1, 2} Zhou Y.... Grummt I. (2009)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines. (PubMed id 11532953)^{1, 3} Strohner R....Grummt I. (2001)
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{1, 2} Nagase T.... Ohara O. (1997)
The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo. (PubMed id 15292447)^{1, 9} Nemeth A....Langst G. (2004)
The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription. (PubMed id 12198165)^{1, 9} Zhou Y....Grummt I. (2002)
Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)¹ Tsai Y.C....Cristea I.M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11176	HGNC: 962	AceView: BAZ2A	Ensembl:ENSG00000076108	euGenes: HUgn11176
ECgene: BAZ2A	H-InvDB: BAZ2A

(According to HUGE)
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HUGE: KIAA0314

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for BAZ2A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for BAZ2A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BAZ2A gene:
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bromodomain adjacent to zinc finger domain, 2A

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bromodomain adjacent to zinc finger domain, 2A

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