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Aliases for BAZ1A Gene

Aliases for BAZ1A Gene

  • Bromodomain Adjacent To Zinc Finger Domain, 1A 2 3
  • Williams Syndrome Transcription Factor-Related Chromatin-Remodeling Factor 180 3 4
  • ATP-Utilizing Chromatin Assembly And Remodeling Factor 1 3 4
  • ATP-Dependent Chromatin-Remodeling Protein 3 4
  • CHRAC Subunit ACF1 3 4
  • WCRF180 3 4
  • HWALp1 3 4
  • HACF1 3 4
  • ACF1 3 4
  • Bromodomain Adjacent To Zinc Finger Domain Protein 1A 3
  • ATP-Dependent Chromatin Remodeling Protein 3
  • WALp1 3

External Ids for BAZ1A Gene

Summaries for BAZ1A Gene

Entrez Gene Summary for BAZ1A Gene

  • The BAZ1A gene encodes the accessory subunit of the ATP-dependent chromatin assembly factor (ACF), a member of the ISWI ('imitation switch') family of chromatin remodeling complexes (summarized by Racki et al., 2009 [PubMed 20033039]).[supplied by OMIM, Apr 2010]

GeneCards Summary for BAZ1A Gene

BAZ1A (Bromodomain Adjacent To Zinc Finger Domain, 1A) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation. GO annotations related to this gene include histone acetyltransferase activity. An important paralog of this gene is KAT2A.

UniProtKB/Swiss-Prot for BAZ1A Gene

  • Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression

  • Component of the histone-fold protein complex CHRAC complex which faciliates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions

Gene Wiki entry for BAZ1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAZ1A Gene

Genomics for BAZ1A Gene

Genomic Location for BAZ1A Gene

Start:
34,752,731 bp from pter
End:
34,875,647 bp from pter
Size:
122,917 bases
Orientation:
Minus strand

Genomic View for BAZ1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAZ1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAZ1A Gene

Regulatory Elements for BAZ1A Gene

Proteins for BAZ1A Gene

  • Protein details for BAZ1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRL2-BAZ1A_HUMAN
    Recommended name:
    Bromodomain adjacent to zinc finger domain protein 1A
    Protein Accession:
    Q9NRL2
    Secondary Accessions:
    • Q9NZ15
    • Q9P065
    • Q9UIG1
    • Q9Y3V3

    Protein attributes for BAZ1A Gene

    Size:
    1556 amino acids
    Molecular mass:
    178702 Da
    Quaternary structure:
    • Component of the ACF chromatin remodeling complex that includes BAZ1A and SMARCA5. Additional this complex can form, together with CHRAC1 and POLE1, the histone-fold protein complex, CHRAC. Interacts with NCOR1 (via its RD1 domain); the interaction corepresses a number of NCOR1-regulated genes.
    Miscellaneous:
    • Stimulated by double-stranded DNA and nucleosomal DNA
    SequenceCaution:
    • Sequence=AAF28995.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for BAZ1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAZ1A Gene

Proteomics data for BAZ1A Gene at MOPED

Post-translational modifications for BAZ1A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys191, Lys570, and Lys973

Other Protein References for BAZ1A Gene

No data available for DME Specific Peptides for BAZ1A Gene

Domains for BAZ1A Gene

Gene Families for BAZ1A Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

UniProtKB/Swiss-Prot:

BAZ1A_HUMAN
Domain:
  • Contains 1 bromo domain.:
    • Q9NRL2
  • Contains 1 DDT domain.:
    • Q9NRL2
  • Contains 1 WAC domain.:
    • Q9NRL2
Family:
  • Belongs to the WAL family.:
    • Q9NRL2
Similarity:
  • Contains 1 PHD-type zinc finger.:
    • Q9NRL2
genes like me logo Genes that share domains with BAZ1A: view

Function for BAZ1A Gene

Molecular function for BAZ1A Gene

UniProtKB/Swiss-Prot Function: Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression
UniProtKB/Swiss-Prot Function: Component of the histone-fold protein complex CHRAC complex which faciliates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions

Gene Ontology (GO) - Molecular Function for BAZ1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 NOT histone acetyltransferase activity TAS 10662543
GO:0005515 protein binding IPI 17500595
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with BAZ1A: view

miRNA for BAZ1A Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BAZ1A Gene

Localization for BAZ1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAZ1A Gene

Nucleus. Note=May target the CHRAC complex to heterochromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAZ1A Gene COMPARTMENTS Subcellular localization image for BAZ1A gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for BAZ1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IEA --
GO:0008623 CHRAC IDA 10880450
GO:0016590 ACF complex TAS 10662543
genes like me logo Genes that share ontologies with BAZ1A: view

Pathways for BAZ1A Gene

genes like me logo Genes that share pathways with BAZ1A: view

Pathways by source for BAZ1A Gene

1 Cell Signaling Technology pathway for BAZ1A Gene

Gene Ontology (GO) - Biological Process for BAZ1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006261 DNA-dependent DNA replication IDA 12434153
GO:0006338 chromatin remodeling TAS 10662543
GO:0006351 transcription, DNA-templated NAS 10662543
GO:0006355 regulation of transcription, DNA-templated NAS 10662543
genes like me logo Genes that share ontologies with BAZ1A: view

Transcripts for BAZ1A Gene

Unigene Clusters for BAZ1A Gene

Bromodomain adjacent to zinc finger domain, 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BAZ1A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6:

ExUns: 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for BAZ1A Gene

GeneLoc Exon Structure for
BAZ1A
ECgene alternative splicing isoforms for
BAZ1A

Expression for BAZ1A Gene

mRNA expression in normal human tissues for BAZ1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BAZ1A Gene

This gene is overexpressed in Whole Blood (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAZ1A Gene

SOURCE GeneReport for Unigene cluster for BAZ1A Gene Hs.509140

mRNA Expression by UniProt/SwissProt for BAZ1A Gene

Q9NRL2-BAZ1A_HUMAN
Tissue specificity: Highly expressed in testis and at low or undetectable levels in other tissues analyzed
genes like me logo Genes that share expressions with BAZ1A: view

Orthologs for BAZ1A Gene

This gene was present in the common ancestor of animals.

Orthologs for BAZ1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAZ1A 36
  • 99.79 (n)
  • 99.61 (a)
BAZ1A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAZ1A 36
  • 93.1 (n)
  • 93.96 (a)
BAZ1A 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAZ1A 36
  • 93.96 (n)
  • 94.99 (a)
BAZ1A 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Baz1a 36
  • 86.31 (n)
  • 87.56 (a)
Baz1a 16
Baz1a 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BAZ1A 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAZ1A 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Baz1a 36
  • 87.24 (n)
  • 87.63 (a)
chicken
(Gallus gallus)
Aves BAZ1A 36
  • 78.05 (n)
  • 79.26 (a)
BAZ1A 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BAZ1A 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia baz1a 36
  • 65.83 (n)
  • 64.01 (a)
Str.17008 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
baz1a 36
  • 66.85 (n)
  • 69.96 (a)
baz1a 37
  • 69 (a)
OneToMany
BAZ1A (2 of 2) 37
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Acf1 37
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea athp-2 37
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToOne
Species with no ortholog for BAZ1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BAZ1A Gene

ENSEMBL:
Gene Tree for BAZ1A (if available)
TreeFam:
Gene Tree for BAZ1A (if available)

Paralogs for BAZ1A Gene

Paralogs for BAZ1A Gene

Selected SIMAP similar genes for BAZ1A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with BAZ1A: view

Variants for BAZ1A Gene

Sequence variations from dbSNP and Humsavar for BAZ1A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs15796 -- 34,800,365(+) TTTTC(C/T)CTTTT reference, synonymous-codon
rs761924 -- 34,864,077(+) ttcag(C/T)ctccc intron-variant
rs1013807 -- 34,847,383(+) TTGAG(A/G)AAAAA intron-variant
rs1044140 - 34,761,902(+) AATAA(A/T)ACACC missense, reference
rs1044149 -- 34,753,036(-) TTATA(A/T)CCTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BAZ1A Gene

Variant ID Type Subtype PubMed ID
nsv1238 CNV Insertion 18451855
nsv517328 CNV Loss 19592680
nsv523492 CNV Loss 19592680
esv268455 CNV Insertion 20981092
esv2661600 CNV Deletion 23128226
esv2667232 CNV Deletion 23128226
esv2506134 CNV Deletion 19546169
esv2382959 CNV Deletion 18987734
esv4428 CNV Deletion 18987735
esv2748588 CNV Deletion 23290073
nsv85433 CNV Loss 16902084
esv2441860 CNV Deletion 19546169
esv6430 CNV Loss 19470904
nsv85205 CNV Loss 16902084
nsv483012 CNV Complex 15286789
dgv369n67 CNV Gain 20364138
esv1006744 CNV Loss 20482838

Relevant External Links for BAZ1A Gene

HapMap Linkage Disequilibrium report
BAZ1A

Disorders for BAZ1A Gene

Relevant External Links for BAZ1A

Genetic Association Database (GAD)
BAZ1A
Human Genome Epidemiology (HuGE) Navigator
BAZ1A
genes like me logo Genes that share disorders with BAZ1A: view

No data available for UniProtKB/Swiss-Prot for BAZ1A Gene

Publications for BAZ1A Gene

  1. An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. (PMID: 12434153) Collins N. … Varga-Weisz P.D. (Nat. Genet. 2002) 3 4 23
  2. A novel family of bromodomain genes. (PMID: 10662543) Jones M.H. … Shimane M. (Genomics 2000) 2 3 4
  3. Novel regulatory role for human Acf1 in transcriptional repression of vitamin D3 receptor-regulated genes. (PMID: 17519354) Ewing A.K. … Chakravarti D. (Mol. Endocrinol. 2007) 3 4 23
  4. The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF. (PMID: 14759371) Kukimoto I. … Varga-Weisz P.D. (Mol. Cell 2004) 3 4
  5. HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. (PMID: 10880450) Poot R.A. … Varga-Weisz P.D. (EMBO J. 2000) 3 4

Products for BAZ1A Gene

Sources for BAZ1A Gene

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