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Aliases for BAX Gene

Aliases for BAX Gene

  • BCL2 Associated X, Apoptosis Regulator 2 3 5
  • BCL2 Associated X Protein 2 3
  • Bcl-2-Like Protein 4 3 4
  • Bcl2-L-4 3 4
  • BCL2L4 3 4
  • BCL2-Associated X Protein Omega 3
  • BCL2-Associated X Protein 2
  • Apoptosis Regulator BAX 3
  • Baxdelta2G9omega 3
  • Baxdelta2omega 3
  • Baxdelta2G9 3

External Ids for BAX Gene

Previous GeneCards Identifiers for BAX Gene

  • GC19P050116
  • GC19P049826
  • GC19P054135
  • GC19P054149
  • GC19P049458
  • GC19P045835

Summaries for BAX Gene

Entrez Gene Summary for BAX Gene

  • The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAX Gene

BAX (BCL2 Associated X, Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BAX include Colorectal Cancer and Leukemia, Acute Lymphoblastic. Among its related pathways are Development IGF-1 receptor signaling and Development HGF signaling pathway. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot for BAX Gene

  • Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Tocris Summary for BAX Gene

  • Bcl-2 family proteins contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four Bcl-2 homology domains. Certain members (Bcl-2, Bcl-XL and Mcl-1) are antiapoptotic, whilst others (Bax, Bak, Bok) are proapoptotic.

Gene Wiki entry for BAX Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAX Gene

Genomics for BAX Gene

Regulatory Elements for BAX Gene

Enhancers for BAX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G048976 1.1 ENCODE dbSUPER 12.3 +21.6 21571 0.6 ATF1 CREB3L1 ARNT ZNF76 DEAF1 DMAP1 ZBTB40 ETS1 ZNF766 ZNF143 BAX DBP SEC1P GC19P048966 GC19P048967 GYS1 RUVBL2
GH19G048898 1.1 ENCODE 11.8 -54.6 -54574 3.8 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 NUCB1 TULP2 PPP1R15A PLEKHA4 BAX FTL DBP SEC1P IRF3 NUCB1-AS1
GH19G048983 0.9 ENCODE 11.8 +28.9 28864 0.1 ATF1 CREB3L1 ZNF76 DEAF1 GLI4 YY1 ETS1 ZNF335 ZNF121 ZNF143 BAX NUCB1-AS1 NUCB1 TULP2 BCAT2 RASIP1 IZUMO1 GYS1 RUVBL2 GC19P048967
GH19G048953 1.4 ENCODE dbSUPER 0.7 +0.5 473 2.7 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 PRR12 PIH1D1 GRWD1 SNORD35A PTOV1-AS2 KDELR1 SNORD35B CYTH2 RPS11 NUP62
GH19G048950 1.3 ENCODE dbSUPER 0.7 -3.8 -3762 1.4 PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF143 NUP62 GRWD1 BCL2L12 SNORD35A PRR12 KDELR1 PIH1D1 AKT1S1 PTOV1-AS2 PNKP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BAX on UCSC Golden Path with GeneCards custom track

Promoters for BAX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110807 185 1201 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1

Transcription factor binding sites by QIAGEN in the BAX gene promoter:

Genomic Location for BAX Gene

Chromosome:
19
Start:
48,954,815 bp from pter
End:
48,961,798 bp from pter
Size:
6,984 bases
Orientation:
Plus strand

Genomic View for BAX Gene

Genes around BAX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAX Gene

Proteins for BAX Gene

  • Protein details for BAX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07812-BAX_HUMAN
    Recommended name:
    Apoptosis regulator BAX
    Protein Accession:
    Q07812
    Secondary Accessions:
    • A8K4W1
    • P55269
    • Q07814
    • Q07815
    • Q8WZ49
    • Q9NR76
    • Q9NYG7
    • Q9UCZ6
    • Q9UCZ7
    • Q9UQD6

    Protein attributes for BAX Gene

    Size:
    192 amino acids
    Molecular mass:
    21184 Da
    Quaternary structure:
    • Homodimer. Forms higher oligomers under stress conditions. Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells. Interacts with FAIM2/LFG2. Interacts with human cytomegalovirus/HHV-5 protein vMIA/UL37. Interacts with BOP/C22orf29. Interacts (via a C-terminal 33 residues) with NOL3 (via CARD domain); inhibits BAX activation and translocation and consequently cytochrome c release from mitochondria.

    Three dimensional structures from OCA and Proteopedia for BAX Gene

    Alternative splice isoforms for BAX Gene

neXtProt entry for BAX Gene

Post-translational modifications for BAX Gene

  • Ubiquitination at posLast=2121
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BAX Gene

Domains & Families for BAX Gene

Gene Families for BAX Gene

Suggested Antigen Peptide Sequences for BAX Gene

Graphical View of Domain Structure for InterPro Entry

Q07812

UniProtKB/Swiss-Prot:

BAX_HUMAN :
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
  • Belongs to the Bcl-2 family.
Domain:
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BAX: view

Function for BAX Gene

Molecular function for BAX Gene

GENATLAS Biochemistry:
BCL2-associated X protein,promoting of apoptosis,21kDa,extensively homolog to BCL2,translocated and inserted into the mitochondrial membrane binding permeability transition pore and increasing the release of cytochrome c,leading to cell death after homodimerization with BCL2,modulating CDK2 activation during thymocyte apoptosis,mutated in gastric carcinomas and in endometrial atypical hyperplasia,determinant of chemo-sensitivity in tumor cell-lines,maybe involved in the tumorigenesis of HNPCC with microsatellite instability and in the uterine cancer,not mutated in acquired immunodeficiency syndrome-related non Hodgkin lymphoma
UniProtKB/Swiss-Prot Function:
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Gene Ontology (GO) - Molecular Function for BAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9027312
GO:0008289 lipid binding IDA 14522999
GO:0015267 channel activity IDA 9219694
GO:0030544 Hsp70 protein binding IEA --
GO:0042802 identical protein binding IPI 10620504
genes like me logo Genes that share ontologies with BAX: view
genes like me logo Genes that share phenotypes with BAX: view

Animal Models for BAX Gene

MGI Knock Outs for BAX:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BAX Gene

Localization for BAX Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAX Gene

Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane.
Isoform Beta: Cytoplasm.
Isoform Gamma: Cytoplasm.
Isoform Delta: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BAX gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IMP 15102863
GO:0005635 nuclear envelope IDA 12925958
GO:0005737 cytoplasm IDA,IEA 16302269
GO:0005739 mitochondrion IEA,IDA 11912183
genes like me logo Genes that share ontologies with BAX: view

Pathways & Interactions for BAX Gene

genes like me logo Genes that share pathways with BAX: view

Pathways by source for BAX Gene

SIGNOR curated interactions for BAX Gene

Gene Ontology (GO) - Biological Process for BAX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0001764 neuron migration IEA --
GO:0001776 leukocyte homeostasis IEA --
GO:0001777 T cell homeostatic proliferation IEA --
GO:0001782 B cell homeostasis IEA --
genes like me logo Genes that share ontologies with BAX: view

Drugs & Compounds for BAX Gene

(79) Drugs for BAX Gene - From: ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gossypol Pharma PAF inhibitor;anti-fertility and anti-cancer, Proapoptotic; downregulates Bcl-2 and Bcl-XL 24
Bax channel blocker Pharma Inhibitor of Bax-mediated mitochondrial cytochrome c release, Inhibits Bax-mediated mitochondrial cytochrome c release 0
AT-101 Pharma BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors 0
BAM7 Pharma BAX activator,direct and selective 0
Bax inhibitor peptide P5 Pharma Bax inhibitor 0

(70) Additional Compounds for BAX Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Maritoclax
1227962-62-0
SMBA 1
906440-37-7

(5) Tocris Compounds for BAX Gene

Compound Action Cas Number
Bax channel blocker Inhibits Bax-mediated mitochondrial cytochrome c release 329349-20-4
Gossypol Proapoptotic; downregulates Bcl-2 and Bcl-XL 303-45-7
Maritoclax Mcl-1 inhibitor; proapoptotic 1227962-62-0
MIM1 Mcl-1 inhibitor; proapoptotic
SMBA 1 High affinity and selective activator of Bax 906440-37-7

(8) ApexBio Compounds for BAX Gene

Compound Action Cas Number
AT-101 BH3-mimetic,gossypol enantiomer 90141-22-3
BAM7 BAX activator,direct and selective 331244-89-4
Bax channel blocker Inhibitor of Bax-mediated mitochondrial cytochrome c release 335165-68-9
Bax inhibitor peptide P5 Bax inhibitor 579492-83-4
Bax inhibitor peptide V5 Bax inhibitor 579492-81-2
Bax inhibitor peptide, negative control Peptide inhibit Bax translocation to mitochondria 1315378-74-5
Gossypol PAF inhibitor;anti-fertility and anti-cancer 303-45-7
PRIMA-1 BAX inhibitor 5608-24-2
genes like me logo Genes that share compounds with BAX: view

Drug Products

Transcripts for BAX Gene

Unigene Clusters for BAX Gene

BCL2-associated X protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAX Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: -
SP2: -
SP3:

Relevant External Links for BAX Gene

GeneLoc Exon Structure for
BAX
ECgene alternative splicing isoforms for
BAX

Expression for BAX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BAX Gene

mRNA differential expression in normal tissues according to GTEx for BAX Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for BAX Gene

This gene is overexpressed in Bone (24.6) and Tlymphocyte (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BAX Gene



Protein tissue co-expression partners for BAX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BAX Gene:

BAX

SOURCE GeneReport for Unigene cluster for BAX Gene:

Hs.624291

mRNA Expression by UniProt/SwissProt for BAX Gene:

Q07812-BAX_HUMAN
Tissue specificity: Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitts lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.

Evidence on tissue expression from TISSUES for BAX Gene

  • Nervous system(4.5)
  • Skin(4.4)
  • Intestine(2.7)
  • Muscle(2.7)
  • Blood(2.3)
  • Lung(2.3)
  • Stomach(2.3)
  • Kidney(2.2)
  • Liver(2.2)
  • Bone marrow(2.1)
  • Heart(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for BAX Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • reproductive
  • urinary
Organs:
Abdomen:
  • intestine
  • kidney
  • large intestine
  • stomach
Pelvis:
  • anus
  • rectum
  • ureter
  • urethra
  • urinary bladder
  • uterus
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with BAX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BAX Gene

Orthologs for BAX Gene

This gene was present in the common ancestor of chordates.

Orthologs for BAX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAX 34 35
  • 99.83 (n)
cow
(Bos Taurus)
Mammalia BAX 34 35
  • 94.44 (n)
dog
(Canis familiaris)
Mammalia BAX 34 35
  • 92.88 (n)
mouse
(Mus musculus)
Mammalia Bax 34 16 35
  • 89.58 (n)
rat
(Rattus norvegicus)
Mammalia Bax 34
  • 89.58 (n)
oppossum
(Monodelphis domestica)
Mammalia BAX 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia bax 34
  • 62.06 (n)
MGC76049 34
African clawed frog
(Xenopus laevis)
Amphibia bax-A 34
zebrafish
(Danio rerio)
Actinopterygii baxa 34 35 35
  • 58.97 (n)
BAX (3 of 5) 35
  • 27 (a)
OneToMany
BAX (5 of 5) 35
  • 20 (a)
OneToMany
baxb 35
  • 20 (a)
OneToMany
bax 34
Species where no ortholog for BAX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAX Gene

ENSEMBL:
Gene Tree for BAX (if available)
TreeFam:
Gene Tree for BAX (if available)

Paralogs for BAX Gene

(4) SIMAP similar genes for BAX Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with BAX: view

No data available for Paralogs for BAX Gene

Variants for BAX Gene

Sequence variations from dbSNP and Humsavar for BAX Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs398122513 Pathogenic, A T-cell acute lymphoblastic leukemia cell line 48,955,799(+) GCATC(A/G)GGGAC intron-variant, nc-transcript-variant, reference, missense
VAR_013576 A Burkitt lymphoma
rs398122840 Pathogenic 48,955,721(+) GGGGG(-/G)AGGCA intron-variant, nc-transcript-variant, reference, frameshift-variant
rs398122841 Pathogenic 48,955,721(+) GGGGG(-/G)AGGCA intron-variant, nc-transcript-variant, reference, frameshift-variant
rs398122842 Pathogenic 48,955,715(+) GAATG(-/GGGGGGG)AGGCA intron-variant, nc-transcript-variant, reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for BAX Gene

Variant ID Type Subtype PubMed ID
dgv3618n100 CNV gain 25217958
esv2665637 CNV deletion 23128226
esv2718694 CNV deletion 23290073
esv3556515 CNV deletion 23714750
nsv1114023 CNV deletion 24896259
nsv1130734 CNV deletion 24896259
nsv833856 CNV loss 17160897
nsv833857 CNV loss 17160897
nsv953598 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for BAX Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BAX Gene

Human Gene Mutation Database (HGMD)
BAX
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BAX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAX Gene

Disorders for BAX Gene

MalaCards: The human disease database

(38) MalaCards diseases for BAX Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
leukemia, acute lymphoblastic
  • leukemia, t-cell acute lymphocytic, somatic
colon adenocarcinoma
  • adenocarcinoma of colon
breast adenocarcinoma
  • adenocarcinoma of breast
malignant teratoma
  • immature teratoma
- elite association - COSMIC cancer census association via MalaCards
Search BAX in MalaCards View complete list of genes associated with diseases

Relevant External Links for BAX

Genetic Association Database (GAD)
BAX
Human Genome Epidemiology (HuGE) Navigator
BAX
Tumor Gene Database (TGDB):
BAX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BAX
genes like me logo Genes that share disorders with BAX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BAX Gene

Publications for BAX Gene

  1. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. (PMID: 20300062) Benard G. … Karbowski M. (EMBO J. 2010) 3 4 22 64
  2. Humanin peptide suppresses apoptosis by interfering with Bax activation. (PMID: 12732850) Guo B. … Reed J.C. (Nature 2003) 3 4 22 64
  3. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. (PMID: 8358790) Oltvai Z.N. … Korsmeyer S.J. (Cell 1993) 2 3 4 64
  4. Human Bop is a novel BH3-only member of the Bcl-2 protein family. (PMID: 23055042) Zhang X. … Tang H. (Protein Cell 2012) 3 4 64
  5. Mutation to Bax beyond the BH3 domain disrupts interactions with pro- survival proteins and promotes apoptosis. (PMID: 21199865) Czabotar P.E. … Colman P.M. (J. Biol. Chem. 2011) 3 4 64

Products for BAX Gene

  • Addgene plasmids for BAX

Sources for BAX Gene

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