Aliases for BATF3 Gene
External Ids for BATF3 Gene
Previous GeneCards Identifiers for BATF3 Gene
This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]
GeneCards Summary for BATF3 Gene
BATF3 (Basic Leucine Zipper ATF-Like Transcription Factor 3) is a Protein Coding gene. Among its related pathways are Dendritic Cells Developmental Lineage Pathway and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is BATF2.
UniProtKB/Swiss-Prot for BATF3 Gene
AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5-TGA[CG]TCA-3 and regulates expression of target genes.