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Aliases for BATF3 Gene

Aliases for BATF3 Gene

  • Basic Leucine Zipper ATF-Like Transcription Factor 3 2 3 5
  • Basic Leucine Zipper Transcription Factor, ATF-Like 3 2 3
  • 21 KDa Small Nuclear Factor Isolated From T-Cells 3 4
  • Jun Dimerization Protein P21SNFT 3 4
  • Jun Dimerization Protein 1 2 3
  • B-ATF-3 3 4
  • SNFT 3 4
  • Basic Leucine Zipper Transcriptional Factor ATF-Like 3 3
  • 21-KD Small Nuclear Factor Isolated From T Cells 3
  • JUNDM1 3
  • JDP1 3

External Ids for BATF3 Gene

Previous GeneCards Identifiers for BATF3 Gene

  • GC01M210927
  • GC01M212859
  • GC01M183536

Summaries for BATF3 Gene

Entrez Gene Summary for BATF3 Gene

  • This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]

GeneCards Summary for BATF3 Gene

BATF3 (Basic Leucine Zipper ATF-Like Transcription Factor 3) is a Protein Coding gene. Among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Dendritic Cells Developmental Lineage Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is BATF.

UniProtKB/Swiss-Prot for BATF3 Gene

  • AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5-TGA[CG]TCA-3 and regulates expression of target genes.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BATF3 Gene

Genomics for BATF3 Gene

Regulatory Elements for BATF3 Gene

Enhancers for BATF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G212691 0.7 FANTOM5 40 +8.2 8171 0.6 PKNOX1 MTA2 BHLHE40 NR2F1 JUNB BMI1 EBF1 DPF2 TBX21 IKZF1 BATF3 GC01P212693 LOC102723761
GH01G212670 1.4 FANTOM5 Ensembl ENCODE 18 +28.4 28436 1.3 KLF17 GLIS2 EGR1 ZNF366 FOS EGR2 ZNF174 CEBPB ZEB2 ZNF398 BATF3 ATF3 RPS6KC1 LOC102723761 GC01P212693
GH01G212977 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.9 -280.2 -280164 5.6 HDAC1 TBP FOXA2 CBX3 TBL1XR1 WRNIP1 BMI1 EGR1 ZNF207 RELB RPS6KC1 VASH2 BATF3 ANGEL2 TATDN3
GH01G212481 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +214.1 214069 8.2 PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 ZNF766 FOS DEK SP3 LOC105372907 ATF3 ANGEL2 BATF3 LOC105372908
GH01G212490 2 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +208.6 208586 1.3 HDGF ARID4B SIN3A ZNF2 ZNF143 ZNF207 ZNF548 ZNF263 SP3 REST LOC105372907 ATF3 BATF3 LOC105372908
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BATF3 on UCSC Golden Path with GeneCards custom track

Promoters for BATF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000019755 85 1401 HDGF PKNOX1 CREB3L1 ZFP64 SIN3A FEZF1 ZNF2 CBX5 ZNF143 ZNF207

Genomic Location for BATF3 Gene

Chromosome:
1
Start:
212,686,417 bp from pter
End:
212,699,985 bp from pter
Size:
13,569 bases
Orientation:
Minus strand

Genomic View for BATF3 Gene

Genes around BATF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BATF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BATF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BATF3 Gene

Proteins for BATF3 Gene

  • Protein details for BATF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR55-BATF3_HUMAN
    Recommended name:
    Basic leucine zipper transcriptional factor ATF-like 3
    Protein Accession:
    Q9NR55

    Protein attributes for BATF3 Gene

    Size:
    127 amino acids
    Molecular mass:
    14468 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.

neXtProt entry for BATF3 Gene

Post-translational modifications for BATF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BATF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for BATF3

No data available for DME Specific Peptides for BATF3 Gene

Domains & Families for BATF3 Gene

Gene Families for BATF3 Gene

Protein Domains for BATF3 Gene

Suggested Antigen Peptide Sequences for BATF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NR55

UniProtKB/Swiss-Prot:

BATF3_HUMAN :
  • Belongs to the bZIP family.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with BATF3: view

Function for BATF3 Gene

Molecular function for BATF3 Gene

UniProtKB/Swiss-Prot Function:
AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5-TGA[CG]TCA-3 and regulates expression of target genes.

Gene Ontology (GO) - Molecular Function for BATF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 15467742
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 15467742
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 10878360
GO:0003714 transcription corepressor activity TAS 10878360
genes like me logo Genes that share ontologies with BATF3: view
genes like me logo Genes that share phenotypes with BATF3: view

Animal Models for BATF3 Gene

MGI Knock Outs for BATF3:

Animal Model Products

CRISPR Products

miRNA for BATF3 Gene

miRTarBase miRNAs that target BATF3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BATF3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BATF3 Gene

Localization for BATF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BATF3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BATF3 gene
Compartment Confidence
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for BATF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS --
genes like me logo Genes that share ontologies with BATF3: view

Pathways & Interactions for BATF3 Gene

genes like me logo Genes that share pathways with BATF3: view

Gene Ontology (GO) - Biological Process for BATF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15467742
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 10878360
genes like me logo Genes that share ontologies with BATF3: view

No data available for SIGNOR curated interactions for BATF3 Gene

Transcripts for BATF3 Gene

mRNA/cDNA for BATF3 Gene

Unigene Clusters for BATF3 Gene

Basic leucine zipper transcription factor, ATF-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BATF3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BATF3 Gene

No ASD Table

Relevant External Links for BATF3 Gene

GeneLoc Exon Structure for
BATF3
ECgene alternative splicing isoforms for
BATF3

Expression for BATF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BATF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BATF3 Gene



Protein tissue co-expression partners for BATF3 Gene

NURSA nuclear receptor signaling pathways regulating expression of BATF3 Gene:

BATF3

SOURCE GeneReport for Unigene cluster for BATF3 Gene:

Hs.62919

Evidence on tissue expression from TISSUES for BATF3 Gene

  • Lung(4.2)
  • Spleen(3.1)
  • Lymph node(2.7)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with BATF3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BATF3 Gene

Orthologs for BATF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BATF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BATF3 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia BATF3 34 35
  • 91.41 (n)
cow
(Bos Taurus)
Mammalia BATF3 34 35
  • 90.48 (n)
rat
(Rattus norvegicus)
Mammalia Batf3 34
  • 87.5 (n)
mouse
(Mus musculus)
Mammalia Batf3 34 16 35
  • 84.18 (n)
oppossum
(Monodelphis domestica)
Mammalia BATF3 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BATF3 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves BATF3 34 35
  • 70.94 (n)
lizard
(Anolis carolinensis)
Reptilia BATF3 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia batf3 34
  • 66.4 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33771 34
zebrafish
(Danio rerio)
Actinopterygii batf3 34 35
  • 65 (n)
Species where no ortholog for BATF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BATF3 Gene

ENSEMBL:
Gene Tree for BATF3 (if available)
TreeFam:
Gene Tree for BATF3 (if available)

Paralogs for BATF3 Gene

Paralogs for BATF3 Gene

(5) SIMAP similar genes for BATF3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BATF3: view

Variants for BATF3 Gene

Sequence variations from dbSNP and Humsavar for BATF3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000156045 -- 212,685,979(+) TACCC(A/G)AATAT downstream-variant-500B
rs1000207982 -- 212,686,263(+) GCCTA(A/G)AAGTG downstream-variant-500B
rs1000236003 -- 212,689,988(+) GTCAT(-/ACAC)ACATA intron-variant
rs1000338125 -- 212,692,626(+) GGAGA(C/T)GGGGT intron-variant
rs1000494757 -- 212,687,344(+) GATCT(C/G)TATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BATF3 Gene

Variant ID Type Subtype PubMed ID
nsv4465 CNV insertion 18451855
nsv549139 CNV gain 21841781

Variation tolerance for BATF3 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.75; 83.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BATF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BATF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BATF3 Gene

Disorders for BATF3 Gene

Relevant External Links for BATF3

Human Genome Epidemiology (HuGE) Navigator
BATF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BATF3

No disorders were found for BATF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BATF3 Gene

Publications for BATF3 Gene

  1. Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions. (PMID: 12087103) Bower K.E. … McGuire K.L. (J. Biol. Chem. 2002) 2 3 4 64
  2. Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein. (PMID: 10878360) Iacobelli M. … McGuire K.L. (J. Immunol. 2000) 2 3 4 64
  3. Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells. (PMID: 15467742) Bower K.E. … McGuire K.L. (Oncogene 2004) 3 4 64
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  5. Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. (PMID: 25642632) Liu H. … Zhang F. (Nat. Genet. 2015) 3 64

Products for BATF3 Gene

Sources for BATF3 Gene

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