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Aliases for BATF2 Gene

Aliases for BATF2 Gene

  • Basic Leucine Zipper Transcription Factor, ATF-Like 2 2 3
  • SARI 3 4 6
  • Suppressor Of AP-1 Regulated By IFN 3 4
  • B-ATF-2 3 4
  • Basic Leucine Zipper Transcriptional Factor ATF-Like 2 3

External Ids for BATF2 Gene

Previous GeneCards Identifiers for BATF2 Gene

  • GC11M064512
  • GC11M064755
  • GC11M061082

Summaries for BATF2 Gene

GeneCards Summary for BATF2 Gene

BATF2 (Basic Leucine Zipper Transcription Factor, ATF-Like 2) is a Protein Coding gene. Diseases associated with BATF2 include acute stress disorder. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is BATF.

UniProtKB/Swiss-Prot for BATF2 Gene

  • AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5-TGA[CG]TCA-3 and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BATF2 Gene

Genomics for BATF2 Gene

Regulatory Elements for BATF2 Gene

Genomic Location for BATF2 Gene

Start:
64,987,943 bp from pter
End:
64,997,045 bp from pter
Size:
9,103 bases
Orientation:
Minus strand

Genomic View for BATF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BATF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BATF2 Gene

Proteins for BATF2 Gene

  • Protein details for BATF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1L9-BATF2_HUMAN
    Recommended name:
    Basic leucine zipper transcriptional factor ATF-like 2
    Protein Accession:
    Q8N1L9
    Secondary Accessions:
    • D9IC56
    • Q8NAF4
    • Q8NAL8
    • Q96EH4

    Protein attributes for BATF2 Gene

    Size:
    274 amino acids
    Molecular mass:
    29398 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with JUN family proteins.

    Alternative splice isoforms for BATF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BATF2 Gene

Proteomics data for BATF2 Gene at MOPED

Post-translational modifications for BATF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BATF2 Gene

Antibody Products

No data available for DME Specific Peptides for BATF2 Gene

Domains for BATF2 Gene

Gene Families for BATF2 Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for BATF2 Gene

Suggested Antigen Peptide Sequences for BATF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1L9

UniProtKB/Swiss-Prot:

BATF2_HUMAN :
  • Q8N1L9
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with BATF2: view

Function for BATF2 Gene

Molecular function for BATF2 Gene

UniProtKB/Swiss-Prot Function:
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5-TGA[CG]TCA-3 and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.
UniProtKB/Swiss-Prot Induction:
By type I interferon. Down-regulated in most hepatocellular carcinoma tumorous tissues (at protein level).

Gene Ontology (GO) - Molecular Function for BATF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with BATF2: view

Phenotypes for BATF2 Gene

genes like me logo Genes that share phenotypes with BATF2: view

Animal Models for BATF2 Gene

MGI Knock Outs for BATF2:

Animal Model Products

miRNA for BATF2 Gene

miRTarBase miRNAs that target BATF2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BATF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BATF2 Gene

Localization for BATF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BATF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BATF2 Gene COMPARTMENTS Subcellular localization image for BATF2 gene
Compartment Confidence
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BATF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with BATF2: view

Pathways for BATF2 Gene

SuperPathways for BATF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BATF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0042832 defense response to protozoan ISS --
GO:0043011 myeloid dendritic cell differentiation ISS --
genes like me logo Genes that share ontologies with BATF2: view

No data available for Pathways by source for BATF2 Gene

Transcripts for BATF2 Gene

Unigene Clusters for BATF2 Gene

Basic leucine zipper transcription factor, ATF-like 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BATF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BATF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: -
SP3:

Relevant External Links for BATF2 Gene

GeneLoc Exon Structure for
BATF2
ECgene alternative splicing isoforms for
BATF2

Expression for BATF2 Gene

mRNA expression in normal human tissues for BATF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BATF2 Gene

This gene is overexpressed in Spleen (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BATF2 Gene

SOURCE GeneReport for Unigene cluster for BATF2 Gene Hs.124840

genes like me logo Genes that share expressions with BATF2: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for BATF2 Gene

Orthologs for BATF2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BATF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BATF2 35
  • 79.93 (n)
  • 70.44 (a)
BATF2 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BATF2 35
  • 78.8 (n)
  • 67.28 (a)
BATF2 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Batf2 35
  • 73.46 (n)
  • 65.56 (a)
Batf2 16
Batf2 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BATF2 35
  • 99.03 (n)
  • 97.81 (a)
BATF2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Batf2 35
  • 72.64 (n)
  • 64.93 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia BATF2 36
  • 39 (a)
OneToOne
Species with no ortholog for BATF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BATF2 Gene

ENSEMBL:
Gene Tree for BATF2 (if available)
TreeFam:
Gene Tree for BATF2 (if available)

Paralogs for BATF2 Gene

Paralogs for BATF2 Gene

Selected SIMAP similar genes for BATF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BATF2: view

Variants for BATF2 Gene

Sequence variations from dbSNP and Humsavar for BATF2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs574381 -- 64,990,032(-) GATGA(C/G)AGCAG intron-variant
rs626670 -- 64,994,307(-) AAAGG(A/G)TCCTG intron-variant
rs674981 -- 64,992,438(-) acaca(C/T)aaatt intron-variant
rs1196903 -- 64,991,538(-) TGACT(C/T)CGTTC upstream-variant-2KB, intron-variant
rs3178436 -- 64,987,945(-) ATCTT(A/T)TCTGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BATF2 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
esv32668 CNV Gain 17666407
esv2750762 CNV Loss 17666407

Relevant External Links for BATF2 Gene

HapMap Linkage Disequilibrium report
BATF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BATF2 Gene

Disorders for BATF2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BATF2 Gene in MalaCards »

(1) Diseases for BATF2 Gene including...

(1) University of Copenhagen DISEASES for BATF2 Gene

genes like me logo Genes that share disorders with BATF2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for BATF2 Gene

Publications for BATF2 Gene

  1. Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN). (PMID: 19074269) Su Z.Z. … Fisher P.B. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4
  2. Decreased expression of BATF2 is associated with a poor prognosis in hepatocellular carcinoma. (PMID: 20473897) Ma H. … Xia J. (Int. J. Cancer 2011) 3 4
  3. Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1. (PMID: 20531301) Dash R. … Fisher P.B. (Oncogene 2010) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for BATF2 Gene

Sources for BATF2 Gene

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