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Aliases for BATF2 Gene

Aliases for BATF2 Gene

  • Basic Leucine Zipper ATF-Like Transcription Factor 2 2 3 5
  • Basic Leucine Zipper Transcription Factor, ATF-Like 2 2 3
  • Suppressor Of AP-1 Regulated By IFN 3 4
  • B-ATF-2 3 4
  • SARI 3 4
  • Basic Leucine Zipper Transcriptional Factor ATF-Like 2 3

External Ids for BATF2 Gene

Previous GeneCards Identifiers for BATF2 Gene

  • GC11M064512
  • GC11M064755
  • GC11M061082

Summaries for BATF2 Gene

GeneCards Summary for BATF2 Gene

BATF2 (Basic Leucine Zipper ATF-Like Transcription Factor 2) is a Protein Coding gene. Diseases associated with BATF2 include Cercarial Dermatitis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is BATF3.

UniProtKB/Swiss-Prot for BATF2 Gene

  • AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5-TGA[CG]TCA-3 and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BATF2 Gene

Genomics for BATF2 Gene

Regulatory Elements for BATF2 Gene

Enhancers for BATF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065307 1.6 FANTOM5 Ensembl ENCODE 21.5 -312.3 -312348 4.8 BRCA1 RAD21 RFX5 ZNF121 GLIS2 ZNF143 RCOR1 DEK SMAD5 CEBPB LOC728975 POLA2 EHD1 BATF2 DPF2 RELA CDC42EP2 EHBP1L1 AP5B1 SPDYC
GH11F065414 1.4 FANTOM5 ENCODE 9.3 -426.5 -426529 18.8 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 NEAT1 ZFPL1 KAT5 EIF1AD LOC105369352 POLA2 MUS81 PCNX3 FRMD8 ENSG00000255320
GH11F064659 0.9 FANTOM5 ENCODE 7.3 +337.1 337134 3.0 HDGF HDAC1 PKNOX1 CBX3 ATF1 ARNT NFRKB RAD21 GATA2 FOS NRXN2 BATF2 ENSG00000237410
GH11F065288 1.1 FANTOM5 Ensembl ENCODE 6.9 -298.1 -298145 14.5 HDGF PKNOX1 ARID4B DMAP1 YY1 SLC30A9 FOS ZNF263 SP5 JUNB POLA2 EHD1 LOC728975 SLC25A45 DPF2 FRMD8 ENSG00000255478 SPDYC CAPN1 PGAM1P8
GH11F064934 0.9 Ensembl ENCODE 4.5 +62.2 62245 1.6 ELF3 TBP ARID4B DMAP1 ZNF48 RAD21 THAP11 SP5 MXD4 KAT8 EEF1A1P18 GPHA2 BATF2 PPP2R5B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BATF2 on UCSC Golden Path with GeneCards custom track

Promoters for BATF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000685582 953 1001 HDGF CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GLIS2

Genomic Location for BATF2 Gene

Chromosome:
11
Start:
64,987,943 bp from pter
End:
64,997,653 bp from pter
Size:
9,711 bases
Orientation:
Minus strand

Genomic View for BATF2 Gene

Genes around BATF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BATF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BATF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BATF2 Gene

Proteins for BATF2 Gene

  • Protein details for BATF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1L9-BATF2_HUMAN
    Recommended name:
    Basic leucine zipper transcriptional factor ATF-like 2
    Protein Accession:
    Q8N1L9
    Secondary Accessions:
    • D9IC56
    • Q8NAF4
    • Q8NAL8
    • Q96EH4

    Protein attributes for BATF2 Gene

    Size:
    274 amino acids
    Molecular mass:
    29398 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with JUN family proteins.

    Alternative splice isoforms for BATF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BATF2 Gene

Post-translational modifications for BATF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BATF2 Gene

No data available for DME Specific Peptides for BATF2 Gene

Domains & Families for BATF2 Gene

Gene Families for BATF2 Gene

Protein Domains for BATF2 Gene

Suggested Antigen Peptide Sequences for BATF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1L9

UniProtKB/Swiss-Prot:

BATF2_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with BATF2: view

Function for BATF2 Gene

Molecular function for BATF2 Gene

UniProtKB/Swiss-Prot Function:
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5-TGA[CG]TCA-3 and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.
UniProtKB/Swiss-Prot Induction:
By type I interferon. Down-regulated in most hepatocellular carcinoma tumorous tissues (at protein level).

Gene Ontology (GO) - Molecular Function for BATF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with BATF2: view
genes like me logo Genes that share phenotypes with BATF2: view

Animal Models for BATF2 Gene

MGI Knock Outs for BATF2:

Animal Model Products

miRNA for BATF2 Gene

miRTarBase miRNAs that target BATF2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BATF2 Gene

Localization for BATF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BATF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BATF2 Gene COMPARTMENTS Subcellular localization image for BATF2 gene
Compartment Confidence
nucleus 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BATF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with BATF2: view

Pathways & Interactions for BATF2 Gene

SuperPathways for BATF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BATF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0030154 cell differentiation IEA --
GO:0042832 defense response to protozoan ISS --
genes like me logo Genes that share ontologies with BATF2: view

No data available for Pathways by source and SIGNOR curated interactions for BATF2 Gene

Transcripts for BATF2 Gene

Unigene Clusters for BATF2 Gene

Basic leucine zipper transcription factor, ATF-like 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BATF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: -
SP3:

Relevant External Links for BATF2 Gene

GeneLoc Exon Structure for
BATF2
ECgene alternative splicing isoforms for
BATF2

Expression for BATF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BATF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BATF2 Gene

This gene is overexpressed in Spleen (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of BATF2 Gene:

BATF2

SOURCE GeneReport for Unigene cluster for BATF2 Gene:

Hs.124840
genes like me logo Genes that share expression patterns with BATF2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for BATF2 Gene

Orthologs for BATF2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BATF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BATF2 34 35
  • 99.03 (n)
cow
(Bos Taurus)
Mammalia BATF2 34 35
  • 79.93 (n)
dog
(Canis familiaris)
Mammalia BATF2 34 35
  • 78.8 (n)
mouse
(Mus musculus)
Mammalia Batf2 34 16 35
  • 73.46 (n)
rat
(Rattus norvegicus)
Mammalia Batf2 34
  • 72.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BATF2 35
  • 39 (a)
OneToOne
Species where no ortholog for BATF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BATF2 Gene

ENSEMBL:
Gene Tree for BATF2 (if available)
TreeFam:
Gene Tree for BATF2 (if available)

Paralogs for BATF2 Gene

Paralogs for BATF2 Gene

(2) SIMAP similar genes for BATF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BATF2: view

Variants for BATF2 Gene

Sequence variations from dbSNP and Humsavar for BATF2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10897540 -- 64,990,024(+) AGATC(C/T)GCCTG intron-variant
rs10897541 -- 64,993,315(+) AGTGG(C/T)GCCAC intron-variant
rs111375653 -- 64,989,001(+) TTTTC(A/G)ACTGT utr-variant-3-prime
rs111395969 -- 64,989,069(+) AGGCC(C/T)GTGTG utr-variant-3-prime
rs111870129 -- 64,995,151(+) CACCG(C/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BATF2 Gene

Variant ID Type Subtype PubMed ID
esv2750762 CNV loss 17666407
esv32668 CNV gain 17666407
nsv526181 CNV gain 19592680
nsv555208 CNV loss 21841781

Variation tolerance for BATF2 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BATF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BATF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BATF2 Gene

Disorders for BATF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BATF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cercarial dermatitis
  • cutaneous schistosomiasis
- elite association - COSMIC cancer census association via MalaCards
Search BATF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BATF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BATF2
genes like me logo Genes that share disorders with BATF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BATF2 Gene

Publications for BATF2 Gene

  1. Decreased expression of BATF2 is associated with a poor prognosis in hepatocellular carcinoma. (PMID: 20473897) Ma H. … Xia J. (Int. J. Cancer 2011) 3 4 64
  2. Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1. (PMID: 20531301) Dash R. … Fisher P.B. (Oncogene 2010) 3 4 64
  3. Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN). (PMID: 19074269) Su Z.Z. … Fisher P.B. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. SARI, a novel target gene of glucocorticoid receptor, plays an important role in dexamethasone-mediated killing of B lymphoma cells. (PMID: 26808579) Huang Y. … He F. (Cancer Lett. 2016) 3 64

Products for BATF2 Gene

Sources for BATF2 Gene

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