Aliases for BATF2 Gene
External Ids for BATF2 Gene
GeneCards Summary for BATF2 Gene
BATF2 (Basic Leucine Zipper Transcription Factor, ATF-Like 2) is a Protein Coding gene. Diseases associated with BATF2 include acute stress disorder. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is BATF.
UniProtKB/Swiss-Prot for BATF2 Gene
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5-TGA[CG]TCA-3 and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.