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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BATF2 Gene

protein-coding   GIFtS: 50
GCID: GC11M064755

basic leucine zipper transcription factor, ATF-like 2

 Explore 7 diseases affiliated with
BATF2 via our new
 Human Malady Compendium 
Biological research products
for BATF2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Basic Leucine Zipper Transcription Factor, ATF-Like 21 2
Suppressor Of AP-1 Regulated By IFN2 3
B-ATF-22 3
SARI2 3
MGC204101
Basic Leucine Zipper Transcriptional Factor ATF-Like 22

External Ids:    HGNC: 251631   Entrez Gene: 1160712   Ensembl: ENSG000001680627   OMIM: 6149835   UniProtKB: Q8N1L93   

Export aliases for BATF2 gene to outside databases

Previous GC identifers: GC11M064512 GC11M061082


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: BATF2_HUMAN, Q8N1L9
Function: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune
system. Following infection, participates to the differentiation of CD8(+) thymic conventional dendritic cells in the
immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence
5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1
transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced
anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and
metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BATF2 gene promoter:
         RFX1   Spz1   MAZR   SREBP-1c   POU3F2   SREBP-1b   Egr-4   SREBP-1a   CP2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBATF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BATF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BATF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

BATF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BATF2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M064755:  view genomic region     (about GC identifiers)

Start:
64,755,415 bp from pter      End:
64,764,517 bp from pter
Size:
9,103 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BATF2_HUMAN, Q8N1L9 (See protein sequence)
Recommended Name: Basic leucine zipper transcriptional factor ATF-like 2  
Size: 274 amino acids; 29398 Da
Subunit: Heterodimer; heterodimerizes with JUN family proteins (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: D9IC56 Q8NAF4 Q8NAL8 Q96EH4
Alternative splicing: 2 isoforms:  Q8N1L9-1   Q8N1L9-2   

Explore the universe of human proteins at neXtProt for BATF2: NX_Q8N1L9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N1L9

  • BATF2 Protein expression data from MOPED and PaxDb:    About this image 
    BATF2 Protein Expression
    REFSEQ proteins: NP_612465.3  
    ENSEMBL proteins: 
     ENSP00000301887   ENSP00000398911   ENSP00000434915   ENSP00000435640  

    Human Recombinant Protein Products for BATF2: 
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    Novus Biologicals BATF2 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BATF2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    BATF2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for BATF2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    BATF2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q8N1L9

    ProtoNet protein and cluster: Q8N1L9

    1 Blocks protein family: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: BATF2_HUMAN, Q8N1L9
    Similarity: Belongs to the bZIP family
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BATF2_HUMAN, Q8N1L9
    Function: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune
    system. Following infection, participates to the differentiation of CD8(+) thymic conventional dendritic cells in the
    immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence
    5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1
    transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced
    anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and
    metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter
    Induction: By type I interferon. Down-regulated in most hepatocellular carcinoma tumorous tissues (at protein level)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046983protein dimerization activity ----
         
    BATF2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Batf2):
     immune system  mortality/aging 

    BATF2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Batf2tm1Kmm for BATF2
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for BATF2 

    miRNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BATF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BATF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for BATF2 (Q8N1L91, 2, 3 ENSP000003018874) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2878283 I2D: score=3 STRING: ENSP00000244769
    DAZAP2Q150381, 2, 3, ENSP000004049684EBI-945729,EBI-724310 MINT-66287 I2D: score=3 STRING: ENSP00000404968
    JUNBP172751, ENSP000003033154EBI-945729,EBI-748062 STRING: ENSP00000303315
    JUNENSP000003602664STRING: ENSP00000360266
    C2orf88ENSP000003451074STRING: ENSP00000345107
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0042832defense response to protozoan ISS--
    GO:0043011myeloid dendritic cell differentiation ISS--

    BATF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BATF2
    Search CenterWatch for drugs/clinical trials and news about BATF2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BATF2 gene: 
    NM_138456.3  

    Unigene Cluster for BATF2:

    Basic leucine zipper transcription factor, ATF-like 2
    Hs.124840  [show with all ESTs]
    Unigene Representative Sequence: NM_138456
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301887(uc001ocf.1) ENST00000435842(uc001oce.1) ENST00000527454(uc021qlb.1)
    ENST00000527716 ENST00000534177

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BATF2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate BATF2:
    hsa-miR-516a-3p hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidBATF2 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Custom design and validation of potent shRNA sequences against BATF2 
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    Additional cDNA sequence: 

    AK092453.1 AK096702.1 AK300917.1 BC011931.2 BC012330.1 HM134154.1 

    3 DOTS entries:

    DT.106758  DT.95163046  DT.91755736 

    24/69 AceView cDNA sequences (see all 69):

    BX112905 AK092453 BM967283 BX282043 BM704163 AK096702 AI298454 CK823507 
    BC011931 AK092761 BC012330 BF023604 BI908638 CA432783 AX747712 BP345318 
    AI281204 CD370349 AA875874 BQ029227 AX747553 AI308934 BM665765 NM_138456 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for BATF2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:                    -                     
    SP2:                    -                     
    SP3:                                          


    ECgene alternative splicing isoforms for BATF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BATF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTCTCCCAG
    BATF2 Expression
    About this image

    BATF2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BATF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BATF2

    SOURCE GeneReport for Unigene cluster: Hs.124840
        SABiosciences Custom PCR Arrays for BATF2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BATF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for BATF2 (if available)
    TreeFam Gene Tree for BATF2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BATF2 gene
    BATF32  BATF2  
    2 SIMAP similar genes for BATF2 using alignment to 3 protein entries:     BATF2_HUMAN (see all proteins):
    BATF3    BATF

    BATF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/185 NCBI SNPs in BATF2 are shown (see all 185    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824917891,2
    --64754963(+) ACAGAA/GCGAGA 1 -- int10--------
    rs1432266061,2
    --64755063(+) CTTGAA/GCCCGG 1 -- int10--------
    rs665660981,2
    C--64755143(+) ATCTC-/AAAAAA 1 -- int12Minor allele frequency- A:0.25NA 4
    rs1138118341,2
    C--64755166(+) AAAAAA/GAAATC 1 -- int10--------
    rs2018490131,2
    --64755181(+) TGTCT-/TCAC  
            
    ACACA
    1 -- int10--------
    rs1383446921,2
    C--64755182(+) GTCTT-/CACACAC 1 -- int10--------
    rs714719641,2
    C--64755183(+) CACAC-/ACACACA 1 -- int11Minor allele frequency- AC:0.50NA 2
    rs79364741,2
    C--64755280(+) CTGAGC/ACTCAG 1 -- int12Minor allele frequency- A:0.00NA 4
    rs1475289461,2
    --64755287(+) TCAGTC/TTCCTC 1 -- int10--------
    rs1401938181,2
    --64755308(+) TTGGAA/GGGAGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for BATF2 (64755415 - 64764517 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for BATF2
         1 CNV: 6934

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    BATF2 for disorders           About GeneDecksing

    OMIM gene information: 614983    OMIM disorders: --

    7 diseases for BATF2:    About MalaCards
    constrictive pericarditis    pericarditis    impetigo    hepatocellular carcinoma
    ataxia    carcinoma    leukemia

    1 disease from the University of Copenhagen DISEASES database for BATF2:
    Acute stress disorder

    Export disorders for BATF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BATF2 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with BATF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Decreased expression of BATF2 is associated with a po or prognosis in hepatocellular carcinoma. (PubMed id 20473897)1, 2 Ma H....Xia J. (2011)
    2. Inhibition of AP-1 by SARI negatively regulates trans formation progression mediated by CCN1. (PubMed id 20531301)1, 2 Dash R....Fisher P.B. (2010)
    3. Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN). (PubMed id 19074269)1, 2 Su Z.Z....Fisher P.B. (2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Transcription suppression of SARI (suppressor of AP-1 , regulated by IFN) by BCR-ABL in human leukemia cells. (PubMed id 21892628)1 Huang Q....Huang S. (2011)
    6. [Influence of BCR-ABL inhibitor STI571 on SARI express ion in K562 cells]. (PubMed id 21867603)1 Huang Q....Huang S.A. (2011)
    7. An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
    8. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116071 HGNC: 25163 AceView: MGC20410 Ensembl:ENSG00000168062 euGenes: HUgn116071
    ECgene: BATF2 H-InvDB: BATF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BATF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BATF2 gene:
    Search GeneIP for patents involving BATF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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    VWF
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    von Willebrand factor
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