Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BATF2 Gene

protein-coding   GIFtS: 49
GCID: GC11M064755

Basic Leucine Zipper Transcription Factor, ATF-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Basic Leucine Zipper Transcription Factor, ATF-Like 21 2
Suppressor Of AP-1 Regulated By IFN2 3
B-ATF-22 3
SARI2 3
Basic Leucine Zipper Transcriptional Factor ATF-Like 22

External Ids:    HGNC: 251631   Entrez Gene: 1160712   Ensembl: ENSG000001680627   OMIM: 6149835   UniProtKB: Q8N1L93   

Export aliases for BATF2 gene to outside databases

Previous GC identifers: GC11M064512 GC11M061082


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for BATF2 Gene: 
BATF2 (basic leucine zipper transcription factor, ATF-like 2) is a protein-coding gene. Diseases associated with BATF2 include acute stress disorder, and constrictive pericarditis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is BATF3.

UniProtKB/Swiss-Prot: BATF2_HUMAN, Q8N1L9
Function: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the
immune system. Following infection, participates to the differentiation of CD8(+) thymic conventional dendritic
cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and
binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively
suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61
and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast
cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61
promoter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BATF2 gene promoter:
         RFX1   Spz1   MAZR   SREBP-1c   POU3F2   SREBP-1b   Egr-4   SREBP-1a   CP2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBATF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BATF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BATF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

BATF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BATF2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M064755:  view genomic region     (about GC identifiers)

Start:
64,755,415 bp from pter      End:
64,764,517 bp from pter
Size:
9,103 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BATF2_HUMAN, Q8N1L9 (See protein sequence)
Recommended Name: Basic leucine zipper transcriptional factor ATF-like 2  
Size: 274 amino acids; 29398 Da
Subunit: Heterodimer; heterodimerizes with JUN family proteins (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: D9IC56 Q8NAF4 Q8NAL8 Q96EH4
Alternative splicing: 2 isoforms:  Q8N1L9-1   Q8N1L9-2   

Explore the universe of human proteins at neXtProt for BATF2: NX_Q8N1L9

Explore proteomics data for BATF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N1L9

  • BATF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BATF2 Protein Expression
    REFSEQ proteins: NP_612465.3  
    ENSEMBL proteins: 
     ENSP00000301887   ENSP00000398911   ENSP00000434915   ENSP00000435640  

    Human Recombinant Protein Products for BATF2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for BATF2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for BATF2
    GenScript Custom Purified and Recombinant Proteins Services for BATF2
    Novus Biologicals BATF2 Protein
    Novus Biologicals BATF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BATF2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    BATF2 for ontologies           About GeneDecksing



    BATF2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for BATF2
    GenScript Custom Superior Antibodies Services for BATF2
    Novus Biologicals BATF2 Antibodies
    Abcam antibodies for BATF2
    Cloud-Clone Corp. Antibodies for BATF2 
    Search ThermoFisher Antibodies for BATF2
    LSBio Antibodies in human, mouse, rat for BATF2 

    Assay Products for BATF2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BATF2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BATF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BATF2 
    Cloud-Clone Corp. CLIAs for BATF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bZIP: basic leucine zipper proteins

    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q8N1L9

    ProtoNet protein and cluster: Q8N1L9

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: BATF2_HUMAN, Q8N1L9
    Similarity: Belongs to the bZIP family
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    BATF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BATF2_HUMAN, Q8N1L9
    Function: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the
    immune system. Following infection, participates to the differentiation of CD8(+) thymic conventional dendritic
    cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and
    binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively
    suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61
    and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast
    cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61
    promoter
    Induction: By type I interferon. Down-regulated in most hepatocellular carcinoma tumorous tissues (at protein
    level)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI16189514
    GO:0043565sequence-specific DNA binding IEA--
         
    BATF2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Batf2):
     immune system  mortality/aging 

    BATF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Batf2tm1Kmm for BATF2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BATF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BATF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BATF2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BATF2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BATF2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate BATF2:
    hsa-miR-516a-3p hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidBATF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BATF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BATF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BATF2
    Sirion Biotech Customized adenovirus for overexpression of BATF2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for BATF2 (see all 5)
    OriGene ORF clones in mouse, rat for BATF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BATF2 (NM_138456)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BATF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BATF2
    Sirion Biotech Customized lentivirus for stable overexpression of BATF2 
                         Customized lentivirus expression plasmids for stable overexpression of BATF2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BATF2
    Search LifeMap BioReagents cell lines for BATF2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BATF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BATF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for BATF2 (Q8N1L91, 2, 3 ENSP000003018874) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2878283 I2D: score=3 STRING: ENSP00000244769
    DAZAP2Q150381, 2, 3, ENSP000004049684EBI-742695,EBI-724310 MINT-66287 I2D: score=3 STRING: ENSP00000404968
    JUNBP172751, ENSP000003033154EBI-742695,EBI-748062 STRING: ENSP00000303315
    JUNENSP000003602664STRING: ENSP00000360266
    C2orf88ENSP000003451074STRING: ENSP00000345107
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0042832defense response to protozoan ISS--
    GO:0043011myeloid dendritic cell differentiation ISS--

    BATF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BATF2

    Search CenterWatch for drugs/clinical trials and news about BATF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BATF2 gene: 
    NM_138456.3  

    Unigene Cluster for BATF2:

    Basic leucine zipper transcription factor, ATF-like 2
    Hs.124840  [show with all ESTs]
    Unigene Representative Sequence: NM_138456
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301887(uc001ocf.1) ENST00000435842(uc001oce.1) ENST00000527454(uc021qlb.1)
    ENST00000527716 ENST00000534177
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BATF2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate BATF2:
    hsa-miR-516a-3p hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidBATF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BATF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BATF2
    Clone
    Products:
         
    OriGene clones in human, mouse for BATF2 (see all 5)
    OriGene ORF clones in mouse, rat for BATF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BATF2 (NM_138456)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BATF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BATF2
    Sirion Biotech Customized lentivirus for stable overexpression of BATF2 
                         Customized lentivirus expression plasmids for stable overexpression of BATF2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BATF2
    OriGene qSTAR qPCR primer pairs in human, mouse for BATF2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BATF2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BATF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BATF2

    Additional mRNA sequence: 

    AK092453.1 AK096702.1 AK300917.1 BC011931.2 BC012330.1 HM134154.1 

    3 DOTS entries:

    DT.106758  DT.95163046  DT.91755736 

    24/69 AceView cDNA sequences (see all 69):

    BF023604 AI298454 AK092453 AA857724 BX112905 AX747712 CK823507 CA432783 
    BI908638 CR612726 BP345318 NM_138456 BM967283 BM704163 AI308934 BX282043 
    AX747553 AI281204 BQ029227 AA875874 BC012330 BM665765 CD370349 AK096702 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for BATF2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:                    -                     
    SP2:                    -                     
    SP3:                                          


    ECgene alternative splicing isoforms for BATF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BATF2 expression in normal human tissues (normalized intensities)      BATF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCTCCCAG
    BATF2 Expression
    About this image


    BATF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier

    See BATF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BATF2

    SOURCE GeneReport for Unigene cluster: Hs.124840
        SABiosciences Custom PCR Arrays for BATF2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BATF2
    OriGene qSTAR qPCR primer pairs in human, mouse for BATF2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BATF2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BATF2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BATF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BATF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for BATF2 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Batf21 , 5 basic leucine zipper transcription factor, ATF-like more1, 5 72.79(n)1
    63.97(a)1
      19 (4.34 cM)5
    744811  NM_028967.11  NP_083243.11 
     61409835 


    ENSEMBL Gene Tree for BATF2 (if available)
    TreeFam Gene Tree for BATF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BATF2 gene
    BATF32  BATF2  
    2 SIMAP similar genes for BATF2 using alignment to 3 protein entries:     BATF2_HUMAN (see all proteins):
    BATF3    BATF

    BATF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/228 SNPs in BATF2 are shown (see all 228)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824917891,2
    --64754963(+) ACAGAA/GCGAGA 1 -- int10--------
    rs1432266061,2
    C--64755063(+) CTTGAA/GCCCGG 1 -- int10--------
    rs665660981,2
    C--64755143(+) ATCTC-/AAAAAA 1 -- int12Minor allele frequency- A:0.25NA 4
    rs1138118341,2
    C--64755166(+) AAAAAA/GAAATC 1 -- int10--------
    rs1129038261,2
    C--64755181(+) GTCTT-/CA    
       
    /CACA
    CACAC
    1 -- int11CSA 2
    rs2018490131,2
    --64755181(+) TGTCT-/TCAC  
            
    ACACA
    1 -- int10--------
    rs1383446921,2
    C--64755182(+) CACAC-/AC/CA 
            
    TCTAT
    1 -- int10--------
    rs714719641,2
    C--64755191(+) CACAC-/ACACACA 1 -- int11Minor allele frequency- AC:0.50NA 2
    rs79364741,2
    C--64755280(+) ctgagC/Actcag 1 -- int12Minor allele frequency- A:0.00NA 4
    rs1475289461,2
    --64755287(+) TCAGTC/TTCCTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for BATF2 (64755415 - 64764517 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BATF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2750762CNV Loss17666407
    nsv526181CNV Gain19592680
    esv32668CNV Gain17666407

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BATF2
    DNA2.0 Custom Variant and Variant Library Synthesis for BATF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614983    OMIM disorders: --

    9 diseases for BATF2:    About MalaCards
    acute stress disorder    constrictive pericarditis    impetigo    pericarditis
    malignant glioma    hepatocellular carcinoma    melanoma    leukemia
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for BATF2:
    Acute stress disorder

    BATF2 for disorders           About GeneDecksing


    Export disorders for BATF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BATF2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with BATF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Decreased expression of BATF2 is associated with a po or prognosis in hepatocellular carcinoma. (PubMed id 20473897)1, 2 Ma H....Xia J. (2011)
    2. Inhibition of AP-1 by SARI negatively regulates trans formation progression mediated by CCN1. (PubMed id 20531301)1, 2 Dash R....Fisher P.B. (2010)
    3. Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN). (PubMed id 19074269)1, 2 Su Z.Z....Fisher P.B. (2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Networks of bZIP protein-protein interactions diversif ied over a billion years of evolution. (PubMed id 23661758)1 Reinke A.W....Keating A.E. (2013)
    6. The function of SARI in modulating epithelial-mesenchy mal transition and lung adenocarcinoma metastasis. (PubMed id 23049725)1 Wang C....Hao X. (2012)
    7. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    8. Transcription suppression of SARI (suppressor of AP-1 , regulated by IFN) by BCR-ABL in human leukemia cells. (PubMed id 21892628)1 Huang Q....Huang S. (2011)
    9. [Influence of BCR-ABL inhibitor STI571 on SARI express ion in K562 cells]. (PubMed id 21867603)1 Huang Q....Huang S.A. (2011)
    10. An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116071 HGNC: 25163 AceView: MGC20410 Ensembl:ENSG00000168062 euGenes: HUgn116071
    ECgene: BATF2 H-InvDB: BATF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BATF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BATF2 gene:
    Search GeneIP for patents involving BATF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for BATF2  
     OriGene qPCR primer pairs and template standards for BATF2   OriGene Protein Over-expression Lysate for BATF2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for BATF2  
     OriGene qSTAR qPCR primer pairs in human, mouse for BATF2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for BATF2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BATF2   OriGene Custom Protein Services for BATF2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BATF2
     QIAGEN SeqTarget long-range PCR primers for resequencing BATF2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BATF2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BATF2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BATF2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BATF2
     GenScript Custom Purified and Recombinant Proteins Services for BATF2 GenScript cDNA clones with any tag delivered in your preferred vector for BATF2
     GenScript Custom Assay Services for BATF2 GenScript Custom Superior Antibodies Services for BATF2
     GenScript Custom overexpressing Cell Line Services for BATF2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in BATF2 promoter
     Search Chromatin IP Primers for BATF2
     RT2 qPCR Primer Assay in human, mouse, rat BATF2
     Search GNC Networks for BATF2
     SABiosciences Custom PCR Arrays for BATF2
     Search Tocris compounds for BATF2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BATF2 antibodies
     BATF2 proteins
     BATF2 lysates
     Antibodies for BATF2
     See all of Abcam's Antibodies, Kits and Proteins for BATF2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for BATF2
     Antibodies for BATF2
     ELISAs for BATF2
     CLIAs for BATF2
     Search LifeMap BioReagents cell lines for BATF2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BATF2
     SwitchGear 3'UTR luciferase reporter plasmids for BATF2
     SwitchGear Promoter luciferase reporter plasmids for BATF2
     Search ThermoFisher Antibodies for BATF2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BATF2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for BATF2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BATF2
    Customized:
     lentivirus for stable overexpression of BATF2
     lentivirus expression plasmids for stable overexpression of BATF2
     adenovirus for overexpression of BATF2
     LSBio Antibodies in human, mouse, rat for BATF2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BATF2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4