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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BATF Gene

protein-coding   GIFtS: 55
GCID: GC14P075988

Basic Leucine Zipper Transcription Factor, ATF-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Basic Leucine Zipper Transcription Factor, ATF-Like1 2     SF-HT-Activated Gene 2 Protein2 3
Activating Transcription Factor B1 2     BATF12 5
B-ATF2 3     SFA22 5
SFA-22 3     SF-HT-Activated Gene 21
B-Cell-Activating Transcription Factor2 3     Basic Leucine Zipper Transcriptional Factor ATF-Like2

External Ids:    HGNC: 9581   Entrez Gene: 105382   Ensembl: ENSG000001561277   OMIM: 6124765   UniProtKB: Q165203   

Export aliases for BATF gene to outside databases

Previous GC identifers: GC14P073494 GC14P069805 GC14P073978 GC14P075058 GC14P056156


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BATF Gene:
The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF
superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of
the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional
events. (provided by RefSeq, Jul 2008)

GeneCards Summary for BATF Gene: 
BATF (basic leucine zipper transcription factor, ATF-like) is a protein-coding gene. Diseases associated with BATF include burkitt's lymphoma, and t-cell leukemia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is BATF2.

UniProtKB/Swiss-Prot: BATF_HUMAN, Q16520
Function: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the
immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells
(TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a
heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also
forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence
(5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or
IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells)
by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and
RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells
(TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by
controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and
constant heavy-chain region (I(H)-C(H)). Following infection, can participate to CD8(+) dendritic cell
differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector
CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation
checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to
differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity)

Gene Wiki entry for BATF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BATF gene promoter:
         STAT1   AP-1   ATF-2   STAT1beta   STAT1alpha   STAT2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBATF promoter sequence
   Search SABiosciences Chromatin IP Primers for BATF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BATF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24

BATF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BATF gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P075988:  view genomic region     (about GC identifiers)

Start:
75,988,768 bp from pter      End:
76,013,358 bp from pter
Size:
24,591 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BATF_HUMAN, Q16520 (See protein sequence)
Recommended Name: Basic leucine zipper transcriptional factor ATF-like  
Size: 125 amino acids; 14120 Da
Subunit: Heterodimer; mainly heterodimerizes with JUNB. The BATF-JUNB heterodimer interacts with IRF4 and IRF8.
Interacts (via bZIP domain) with IRF4 and IRF8; the interaction is direct (By similarity). Also forms
heterodimers with JUN and JUND. Also interacts with IFI35
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Note=Present in the nucleus and
cytoplasm, but shows increased nuclear translocation after activation of T-cells (By similarity)

Explore the universe of human proteins at neXtProt for BATF: NX_Q16520

Explore proteomics data for BATF at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43
    inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription (By
    similarity)
  • UniProtKB: Phosphorylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16520

  • BATF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BATF Protein Expression
    REFSEQ proteins: NP_006390.1  
    ENSEMBL proteins: 
     ENSP00000286639   ENSP00000450486  

    Human Recombinant Protein Products for BATF: 
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    OriGene MassSpec for BATF 
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    Novus Biologicals BATF Proteins
    Novus Biologicals BATF Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for BATF
    Cloud-Clone Corp. Proteins for BATF 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--

    BATF for ontologies           About GeneDecksing



    BATF Antibody Products: 
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    Cloud-Clone Corp. Antibodies for BATF 
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    LSBio Antibodies in human, mouse, rat for BATF 

    Assay Products for BATF: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BATF 
    Cloud-Clone Corp. CLIAs for BATF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bZIP: basic leucine zipper proteins

    2 InterPro protein domains:
     IPR004827 bZIP
     IPR000837 Leuzip_Fos

    Graphical View of Domain Structure for InterPro Entry Q16520

    ProtoNet protein and cluster: Q16520

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: BATF_HUMAN, Q16520
    Similarity: Belongs to the bZIP family
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    BATF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BATF_HUMAN, Q16520
    Function: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the
    immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells
    (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a
    heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also
    forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence
    (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or
    IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells)
    by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and
    RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells
    (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by
    controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and
    constant heavy-chain region (I(H)-C(H)). Following infection, can participate to CD8(+) dendritic cell
    differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector
    CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation
    checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to
    differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity)
    Induction: Up-regulated by PDCD1 following infection by HIV-1 virus, leading to inhibit T-cell functions and
    exhaust T-cells. Up-regulated by Epstein-Barr virus (EBV) protein EBNA2 following infection by EBV

         Genatlas biochemistry entry for BATF:
    activation transcription factor expressed on B and T cells after induction respectively by EB virus and
    HTLV1,ATF/AP-1 family

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ISS--
    GO:0005515protein binding IPI8954125
    GO:0043565sequence-specific DNA binding ISS--
         
    BATF for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Batf):
     cellular  hematopoietic system  immune system 

    BATF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BATF: Batftm1.1Ejt Batftm1.1Kmm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BATF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BATF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BATF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BATF 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BATF
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    SwitchGear 3'UTR luciferase reporter plasmidBATF 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of BATF

    Clone
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    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of BATF 

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    Search LifeMap BioReagents cell lines for BATF
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BATF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BATF About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    2MAP Kinase Signaling
    MAP Kinase Signaling
    3Lymphocyte Signaling
    Lymphocyte Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for BATF
        MAP Kinase Signaling
    Lymphocyte Signaling

    1 PharmGKB Pathway for BATF
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics


    BATF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BATF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/27 Interacting proteins for BATF (Q165202, 3 ENSP000002866394) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNAPC5O759712, 3, ENSP000003195974MINT-67538 I2D: score=5 STRING: ENSP00000319597
    DDIT3P356382, 3, ENSP000003406714MINT-68453 I2D: score=6 STRING: ENSP00000340671
    JUNBP172753, ENSP000003033154I2D: score=7 STRING: ENSP00000303315
    JUNP054123, ENSP000003602664I2D: score=3 STRING: ENSP00000360266
    JUNDP175353, ENSP000002528184I2D: score=3 STRING: ENSP00000252818
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production ISS--
    GO:0002320lymphoid progenitor cell differentiation ISS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006974response to DNA damage stimulus ISS--

    BATF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BATF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BATF

    1 HMDB Compound for BATF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    2 Novoseek inferred chemical compound relationships for BATF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 45.3 4 10777209 (2), 8570175 (1)
    serine 30.9 2 8630063 (1), 12809553 (1)

    Search CenterWatch for drugs/clinical trials and news about BATF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BATF gene: 
    NM_006399.3  

    Unigene Cluster for BATF:

    Basic leucine zipper transcription factor, ATF-like
    Hs.509964  [show with all ESTs]
    Unigene Representative Sequence: BQ053419
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286639(uc001xrr.3) ENST00000555795 ENST00000555504
    miRNA
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    Inhib. RNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BATF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BATF

    Additional mRNA sequence: 

    BC032294.1 D42106.1 U15460.1 

    2 DOTS entries:

    DT.111181  DT.75101496 

    24/43 AceView cDNA sequences (see all 43):

    BQ447098 BQ446291 D42106 CD743175 BQ053419 BM821174 CA308932 BM794048 
    BM978956 NM_006399 AI668791 U15460 AI339276 BE730289 BG236313 BU595472 
    AI313510 AA879469 BC032294 BM851019 AI923546 CB853440 BQ052152 BU838942 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for BATF    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:        -                     
    SP2:                              


    ECgene alternative splicing isoforms for BATF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BATF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACAGAGCA
    BATF Expression
    About this image


    See BATF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BATF

    SOURCE GeneReport for Unigene cluster: Hs.509964

    UniProtKB/Swiss-Prot: BATF_HUMAN, Q16520
    Tissue specificity: Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen,
    and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines,
    including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate
    levels in lymph node and appendix and at low levels in thymus and bone marrow (PubMed:10777209)

        SABiosciences Custom PCR Arrays for BATF
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BATF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BATF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BATF gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Batf1 , 5 basic leucine zipper transcription factor, ATF-like1, 5 90.13(n)1
    96(a)1
      12 (39.78 cM)5
    533141  NM_016767.21  NP_058047.11 
     856866695 
    chicken
    (Gallus gallus)
    Aves BATF1 basic leucine zipper transcription factor, ATF-like 79.57(n)
    83.87(a)
      423364  XM_421279.3  XP_421279.2 
    lizard
    (Anolis carolinensis)
    Reptilia BATF6
    Uncharacterized protein
    72(a)
    1 ↔ 1
    1(22314264-22330979)
    zebrafish
    (Danio rerio)
    Actinopterygii batf1 basic leucine zipper transcription factor, ATF-like 69.18(n)
    69.89(a)
      564589  NM_001045059.1  NP_001038524.1 


    ENSEMBL Gene Tree for BATF (if available)
    TreeFam Gene Tree for BATF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BATF gene
    BATF22  BATF32  
    7 SIMAP similar genes for BATF using alignment to 2 protein entries:     BATF_HUMAN (see all proteins):
    BATF3    BATF2    FOSL2    FOSB    JDP2    ATF3
    FOS

    BATF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/628 SNPs in BATF are shown (see all 628)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871075781,2
    --75986793(+) GTGGAA/GGAGAA 1 -- us2k10--------
    rs1905549001,2
    --75986827(+) GACCAG/TTCAAT 1 -- us2k10--------
    rs727236151,2
    --75986843(+) GCCAAC/TCTACC 1 -- us2k10--------
    rs101488481,2
    C--75986848(+) cctacC/Tagctg 1 -- us2k10--------
    rs1473482421,2
    --75986871(+) TGACCC/GAGCCT 1 -- us2k10--------
    rs1176070791,2
    F--75986880(+) CTAGCC/TGAGAT 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1810925901,2
    --75986965(+) TCATCA/GAAGTT 1 -- us2k10--------
    rs1854795251,2
    --75986991(+) GGCAGC/TGAACA 1 -- us2k10--------
    rs790872741,2
    C,F--75987087(+) TGCACC/TATGAA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs791813661,2
    C,F--75987093(+) ATGAAC/TGTTTG 1 -- us2k11Minor allele frequency- T:0.09WA 118

    HapMap Linkage Disequilibrium report for BATF (75988768 - 76013358 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BATF: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BATF
    DNA2.0 Custom Variant and Variant Library Synthesis for BATF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612476    OMIM disorders: --

    7 diseases for BATF:    About MalaCards
    burkitt's lymphoma    t-cell leukemia    rheumatoid arthritis    arthritis
    colorectal cancer    multiple sclerosis    leukemia


    BATF for disorders           About GeneDecksing

    Genetic Association Database (GAD): BATF

    Export disorders for BATF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BATF gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with BATF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. (PubMed id 8570175)1, 2, 3, 9 Dorsey M.J.... Taparowsky E.J. (1995)
    2. SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes. (PubMed id 8630063)1, 2, 3, 9 Hasegawa H....Fujita S. (1996)
    3. B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos. (PubMed id 10777209)1, 2, 9 Echlin D.R.... Taparowsky E.J. (2000)
    4. EBNA2 and activated Notch induce expression of BATF. (PubMed id 12719594)1, 2, 9 Johansen L.M....Taparowsky E.J. (2003)
    5. Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (2011)
    6. Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF. (PubMed id 20890291)1, 2 Quigley M....Haining W.N. (2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    9. Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1. (PubMed id 9745044)1, 2 Meyer N.P....Taparowsky E.J. (1998)
    10. IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors. (PubMed id 8954125)1, 2 Wang X.... Taparowsky E.J. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10538 HGNC: 958 AceView: BATF Ensembl:ENSG00000156127 euGenes: HUgn10538
    ECgene: BATF H-InvDB: BATF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BATF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BATF gene:
    Search GeneIP for patents involving BATF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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