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Aliases for BATF Gene

Aliases for BATF Gene

  • Basic Leucine Zipper ATF-Like Transcription Factor 2 3
  • Basic Leucine Zipper Transcription Factor, ATF-Like 2 3 5
  • B-Cell-Activating Transcription Factor 3 4
  • Activating Transcription Factor B 2 3
  • SF-HT-Activated Gene 2 Protein 3 4
  • B-ATF 3 4
  • SFA-2 3 4
  • SF-HT-Activated Gene 2 2
  • BATF1 3
  • SFA2 3

External Ids for BATF Gene

Previous GeneCards Identifiers for BATF Gene

  • GC14P073494
  • GC14P069805
  • GC14P073978
  • GC14P075058
  • GC14P075988
  • GC14P056156

Summaries for BATF Gene

Entrez Gene Summary for BATF Gene

  • The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]

GeneCards Summary for BATF Gene

BATF (Basic Leucine Zipper ATF-Like Transcription Factor) is a Protein Coding gene. Among its related pathways are NF-kappaB Signaling and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is BATF2.

UniProtKB/Swiss-Prot for BATF Gene

  • AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5-TGA[CG]TCA-3. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5-TGAnTCA/GAAA-3), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).

Gene Wiki entry for BATF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BATF Gene

Genomics for BATF Gene

Regulatory Elements for BATF Gene

Enhancers for BATF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BATF on UCSC Golden Path with GeneCards custom track

Promoters for BATF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BATF on UCSC Golden Path with GeneCards custom track

Genomic Location for BATF Gene

Chromosome:
14
Start:
75,522,425 bp from pter
End:
75,547,015 bp from pter
Size:
24,591 bases
Orientation:
Plus strand

Genomic View for BATF Gene

Genes around BATF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BATF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BATF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BATF Gene

Proteins for BATF Gene

  • Protein details for BATF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16520-BATF_HUMAN
    Recommended name:
    Basic leucine zipper transcriptional factor ATF-like
    Protein Accession:
    Q16520

    Protein attributes for BATF Gene

    Size:
    125 amino acids
    Molecular mass:
    14120 Da
    Quaternary structure:
    • Heterodimer; mainly heterodimerizes with JUNB. The BATF-JUNB heterodimer interacts with IRF4 and IRF8. Interacts (via bZIP domain) with IRF4 and IRF8; the interaction is direct (By similarity). Also forms heterodimers with JUN and JUND. Also interacts with IFI35.

neXtProt entry for BATF Gene

Proteomics data for BATF Gene at MOPED

Post-translational modifications for BATF Gene

  • Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription (By similarity).
  • Phosphorylated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BATF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BATF (BATF)

No data available for DME Specific Peptides for BATF Gene

Domains & Families for BATF Gene

Gene Families for BATF Gene

Protein Domains for BATF Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BATF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16520

UniProtKB/Swiss-Prot:

BATF_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with BATF: view

Function for BATF Gene

Molecular function for BATF Gene

GENATLAS Biochemistry:
activation transcription factor expressed on B and T cells after induction respectively by EB virus and HTLV1,ATF/AP-1 family
UniProtKB/Swiss-Prot Function:
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5-TGA[CG]TCA-3. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5-TGAnTCA/GAAA-3), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by PDCD1 following infection by HIV-1 virus, leading to inhibit T-cell functions and exhaust T-cells. Up-regulated by Epstein-Barr virus (EBV) protein EBNA2 following infection by EBV.

Gene Ontology (GO) - Molecular Function for BATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 8954125
genes like me logo Genes that share ontologies with BATF: view
genes like me logo Genes that share phenotypes with BATF: view

Animal Models for BATF Gene

MGI Knock Outs for BATF:

Animal Model Products

miRNA for BATF Gene

miRTarBase miRNAs that target BATF
Targeted motifs for BATF Gene
HOMER Transcription Factor Regulatory Elements motif BATF
  • Consensus sequence: DATGASTCAT Submotif: canonical Cell Type: Th17 GEO ID: GSE39756

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for BATF Gene

Localization for BATF Gene

Subcellular locations from UniProtKB/Swiss-Prot for BATF Gene

Nucleus. Cytoplasm. Note=Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BATF Gene COMPARTMENTS Subcellular localization image for BATF gene
Compartment Confidence
nucleus 5
chloroplast 1

No data available for Gene Ontology (GO) - Cellular Components for BATF Gene

Pathways & Interactions for BATF Gene

genes like me logo Genes that share pathways with BATF: view

Pathways by source for BATF Gene

2 Cell Signaling Technology pathways for BATF Gene
1 PharmGKB pathway for BATF Gene

Gene Ontology (GO) - Biological Process for BATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA,ISS --
GO:0002320 lymphoid progenitor cell differentiation IEA,ISS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006974 cellular response to DNA damage stimulus IEA,ISS --
GO:0030330 DNA damage response, signal transduction by p53 class mediator IEA,ISS --
genes like me logo Genes that share ontologies with BATF: view

No data available for SIGNOR curated interactions for BATF Gene

Drugs & Compounds for BATF Gene

(3) Drugs for BATF Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with BATF: view

Transcripts for BATF Gene

mRNA/cDNA for BATF Gene

Unigene Clusters for BATF Gene

Basic leucine zipper transcription factor, ATF-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BATF Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for BATF Gene

GeneLoc Exon Structure for
BATF
ECgene alternative splicing isoforms for
BATF

Expression for BATF Gene

mRNA expression in normal human tissues for BATF Gene

mRNA differential expression in normal tissues according to GTEx for BATF Gene

This gene is overexpressed in Whole Blood (x13.4) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for BATF Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BATF Gene



SOURCE GeneReport for Unigene cluster for BATF Gene Hs.509964

mRNA Expression by UniProt/SwissProt for BATF Gene

Q16520-BATF_HUMAN
Tissue specificity: Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitts lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow (PubMed:10777209).
genes like me logo Genes that share expression patterns with BATF: view

Protein tissue co-expression partners for BATF Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BATF Gene

Orthologs for BATF Gene

This gene was present in the common ancestor of chordates.

Orthologs for BATF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BATF 35
  • 91.59 (n)
  • 93.46 (a)
BATF 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BATF 35
  • 92.21 (n)
  • 96.26 (a)
BATF 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Batf 35
  • 88.47 (n)
  • 95.33 (a)
Batf 16
Batf 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BATF 35
  • 99.73 (n)
  • 100 (a)
BATF 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Batf 35
  • 88.79 (n)
  • 95.33 (a)
oppossum
(Monodelphis domestica)
Mammalia BATF 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves BATF 35
  • 79.68 (n)
  • 83.81 (a)
BATF 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BATF 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia batf 35
  • 65.25 (n)
  • 68.09 (a)
zebrafish
(Danio rerio)
Actinopterygii batf 35
  • 69.18 (n)
  • 69.89 (a)
batf 36
  • 63 (a)
OneToOne
Species with no ortholog for BATF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BATF Gene

ENSEMBL:
Gene Tree for BATF (if available)
TreeFam:
Gene Tree for BATF (if available)

Paralogs for BATF Gene

Paralogs for BATF Gene

(7) SIMAP similar genes for BATF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BATF: view

Variants for BATF Gene

Sequence variations from dbSNP and Humsavar for BATF Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10091 -- 75,546,758(+) TCCAC(A/C)TGGAG utr-variant-3-prime
rs175720 -- 75,521,043(+) ctctg(A/G)tatcc upstream-variant-2KB
rs175721 -- 75,521,788(+) TTTCT(C/G)CATTC upstream-variant-2KB
rs175722 -- 75,522,943(+) ATTCT(G/T)CCAAA intron-variant
rs175723 -- 75,523,234(+) AGAAG(A/G)AGAGG intron-variant

Variation tolerance for BATF Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for BATF Gene

Disorders for BATF Gene

Relevant External Links for BATF

Genetic Association Database (GAD)
BATF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BATF

No disorders were found for BATF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BATF Gene

Publications for BATF Gene

  1. B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. (PMID: 8570175) Dorsey M.J. … Taparowsky E.J. (Oncogene 1995) 2 3 4 23 67
  2. SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes. (PMID: 8630063) Hasegawa H. … Fujita S. (Biochem. Biophys. Res. Commun. 1996) 2 3 23
  3. EBNA2 and activated Notch induce expression of BATF. (PMID: 12719594) Johansen L.M. … Taparowsky E.J. (J. Virol. 2003) 3 23
  4. Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation. (PMID: 12809553) Deppmann C.D. … Taparowsky E.J. (Biochem. J. 2003) 3 23
  5. B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos. (PMID: 10777209) Echlin D.R. … Taparowsky E.J. (Oncogene 2000) 3 23

Products for BATF Gene

Sources for BATF Gene

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