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Aliases for BATF Gene

Aliases for BATF Gene

  • Basic Leucine Zipper Transcription Factor, ATF-Like 2 3
  • B-Cell-Activating Transcription Factor 3 4
  • Activating Transcription Factor B 2 3
  • SF-HT-Activated Gene 2 Protein 3 4
  • BATF1 3 6
  • B-ATF 3 4
  • SFA-2 3 4
  • SFA2 3 6
  • Basic Leucine Zipper Transcriptional Factor ATF-Like 3
  • SF-HT-Activated Gene 2 2

External Ids for BATF Gene

Previous GeneCards Identifiers for BATF Gene

  • GC14P073494
  • GC14P069805
  • GC14P073978
  • GC14P075058
  • GC14P075988
  • GC14P056156

Summaries for BATF Gene

Entrez Gene Summary for BATF Gene

  • The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]

GeneCards Summary for BATF Gene

BATF (Basic Leucine Zipper Transcription Factor, ATF-Like) is a Protein Coding gene. Among its related pathways are MAPK targets/ Nuclear events mediated by MAP kinases and Lymphocyte Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is BATF2.

UniProtKB/Swiss-Prot for BATF Gene

  • AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5-TGA[CG]TCA-3. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5-TGAnTCA/GAAA-3), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).

Gene Wiki entry for BATF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BATF Gene

Genomics for BATF Gene

Regulatory Elements for BATF Gene

Genomic Location for BATF Gene

Start:
75,522,425 bp from pter
End:
75,547,015 bp from pter
Size:
24,591 bases
Orientation:
Plus strand

Genomic View for BATF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BATF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BATF Gene

Proteins for BATF Gene

  • Protein details for BATF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16520-BATF_HUMAN
    Recommended name:
    Basic leucine zipper transcriptional factor ATF-like
    Protein Accession:
    Q16520
    Secondary Accessions:

    Protein attributes for BATF Gene

    Size:
    125 amino acids
    Molecular mass:
    14120 Da
    Quaternary structure:
    • Heterodimer; mainly heterodimerizes with JUNB. The BATF-JUNB heterodimer interacts with IRF4 and IRF8. Interacts (via bZIP domain) with IRF4 and IRF8; the interaction is direct (By similarity). Also forms heterodimers with JUN and JUND. Also interacts with IFI35.

neXtProt entry for BATF Gene

Proteomics data for BATF Gene at MOPED

Post-translational modifications for BATF Gene

  • Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription (By similarity).
  • Phosphorylated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BATF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BATF Gene

Domains for BATF Gene

Gene Families for BATF Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for BATF Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BATF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16520

UniProtKB/Swiss-Prot:

BATF_HUMAN :
  • Q16520
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with BATF: view

Function for BATF Gene

Molecular function for BATF Gene

GENATLAS Biochemistry: activation transcription factor expressed on B and T cells after induction respectively by EB virus and HTLV1,ATF/AP-1 family
UniProtKB/Swiss-Prot Function: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5-TGA[CG]TCA-3. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5-TGAnTCA/GAAA-3), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated by PDCD1 following infection by HIV-1 virus, leading to inhibit T-cell functions and exhaust T-cells. Up-regulated by Epstein-Barr virus (EBV) protein EBNA2 following infection by EBV.

Gene Ontology (GO) - Molecular Function for BATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity ISS --
GO:0005515 protein binding IPI 18692475
GO:0043565 sequence-specific DNA binding ISS --
genes like me logo Genes that share ontologies with BATF: view

Phenotypes for BATF Gene

genes like me logo Genes that share phenotypes with BATF: view

Animal Models for BATF Gene

MGI Knock Outs for BATF:

miRNA for BATF Gene

miRTarBase miRNAs that target BATF
Targeting motifs for BATF Gene
HOMER Transcription Factor Regulatory Elements motif BATF
  • Consensus sequence: DATGASTCAT Submotif: canonical Cell Type: Th17 GeoId: GSE39756

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for BATF Gene

Localization for BATF Gene

Subcellular locations from UniProtKB/Swiss-Prot for BATF Gene

Nucleus. Cytoplasm. Note=Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BATF Gene COMPARTMENTS Subcellular localization image for BATF gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for BATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with BATF: view

Pathways for BATF Gene

genes like me logo Genes that share pathways with BATF: view

Pathways by source for BATF Gene

2 Cell Signaling Technology pathways for BATF Gene
1 PharmGKB pathway for BATF Gene

Gene Ontology (GO) - Biological Process for BATF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production ISS --
GO:0002320 lymphoid progenitor cell differentiation ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with BATF: view

Compounds for BATF Gene

(1) HMDB Compounds for BATF Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(2) Novoseek inferred chemical compound relationships for BATF Gene

Compound -log(P) Hits PubMed IDs
leucine 45.3 3
serine 30.9 2
genes like me logo Genes that share compounds with BATF: view

Transcripts for BATF Gene

mRNA/cDNA for BATF Gene

(43) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BATF Gene

Basic leucine zipper transcription factor, ATF-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BATF Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for BATF Gene

GeneLoc Exon Structure for
BATF
ECgene alternative splicing isoforms for
BATF

Expression for BATF Gene

mRNA expression in normal human tissues for BATF Gene

mRNA differential expression in normal tissues according to GTEx for BATF Gene

This gene is overexpressed in Whole Blood (13.4) and Spleen (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BATF Gene

SOURCE GeneReport for Unigene cluster for BATF Gene Hs.509964

mRNA Expression by UniProt/SwissProt for BATF Gene

Q16520-BATF_HUMAN
Tissue specificity: Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitts lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow (PubMed:10777209).
genes like me logo Genes that share expressions with BATF: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BATF Gene

Orthologs for BATF Gene

This gene was present in the common ancestor of chordates.

Orthologs for BATF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BATF 35
  • 99.73 (n)
  • 100 (a)
BATF 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BATF 35
  • 91.59 (n)
  • 93.46 (a)
BATF 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BATF 35
  • 92.21 (n)
  • 96.26 (a)
BATF 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Batf 35
  • 88.47 (n)
  • 95.33 (a)
Batf 16
Batf 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BATF 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Batf 35
  • 88.79 (n)
  • 95.33 (a)
chicken
(Gallus gallus)
Aves BATF 35
  • 79.68 (n)
  • 83.81 (a)
BATF 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BATF 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia batf 35
  • 65.25 (n)
  • 68.09 (a)
zebrafish
(Danio rerio)
Actinopterygii batf 35
  • 69.18 (n)
  • 69.89 (a)
batf 36
  • 63 (a)
OneToOne
Species with no ortholog for BATF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BATF Gene

ENSEMBL:
Gene Tree for BATF (if available)
TreeFam:
Gene Tree for BATF (if available)

Paralogs for BATF Gene

Paralogs for BATF Gene

Selected SIMAP similar genes for BATF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BATF: view

Variants for BATF Gene

Sequence variations from dbSNP and Humsavar for BATF Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs10091 -- 75,546,758(+) TCCAC(A/C)TGGAG utr-variant-3-prime
rs175720 -- 75,521,043(+) ctctg(A/G)tatcc upstream-variant-2KB
rs175721 -- 75,521,788(+) TTTCT(C/G)CATTC upstream-variant-2KB
rs175722 -- 75,522,943(+) ATTCT(G/T)CCAAA intron-variant
rs175723 -- 75,523,234(+) AGAAG(A/G)AGAGG intron-variant

Relevant External Links for BATF Gene

HapMap Linkage Disequilibrium report
BATF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BATF Gene

Disorders for BATF Gene

Relevant External Links for BATF

Genetic Association Database (GAD)
BATF
genes like me logo Genes that share disorders with BATF: view

No data available for UniProtKB/Swiss-Prot for BATF Gene

Publications for BATF Gene

  1. B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. (PMID: 8570175) Dorsey M.J. … Taparowsky E.J. (Oncogene 1995) 2 3 4 23
  2. SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes. (PMID: 8630063) Hasegawa H. … Fujita S. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23
  3. B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos. (PMID: 10777209) Echlin D.R. … Taparowsky E.J. (Oncogene 2000) 3 4 23
  4. EBNA2 and activated Notch induce expression of BATF. (PMID: 12719594) Johansen L.M. … Taparowsky E.J. (J. Virol. 2003) 3 4 23
  5. Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation. (PMID: 12809553) Deppmann C.D. … Taparowsky E.J. (Biochem. J. 2003) 3 23

Products for BATF Gene

Sources for BATF Gene

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