BASP1 Gene
protein-coding GIFtS: 53
GCID: GC05P017217
|
|
brain abundant, membrane attached signal protein 1
| |
Aliases
for BASP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Brain Abundant, Membrane Attached Signal Protein 11 2 | | Neuronal Axonal Membrane Protein NAP-222 3 | | NAP221 2 3 5 | | 22 KDa Neuronal Tissue-Enriched Acidic Protein2 3 | | CAP231 2 5 | | Brain Acid Soluble Protein 12 | | CAP-231 2 | | Brain Acid-Soluble Protein 12 | | NAP-221 2 | | Neuronal Tissue-Enriched Acidic Protein2 |
Export aliases for BASP1 gene to outside databasesPrevious GC identifers: GC05P017265 GC05P017495 GC05P017270 |
Summaries
for BASP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BASP1:
This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservationof proteins with PEST sequences among different species supports their functional significance. PEST sequencestypically occur in proteins with high turnover rates. Immunological characteristics of this protein are speciesspecific. This protein also undergoes N-terminal myristoylation. Alternative splicing results in multiple transcriptvariants that encode the same protein. (provided by RefSeq, Oct 2012)
Gene Wiki entry for BASP1
|
Genomic Views
for BASP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006576.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BASP1 gene promoter:
c-Fos C/EBPbeta Sox5 AP-1 RREB-1 ATF-2 GATA-6 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for BASP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BASP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p15.1 Ensembl cytogenetic band: 5p15.1 HGNC cytogenetic band: 5p15.1BASP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P017217: view genomic region
(about GC identifiers)
Start:
|
17,217,669 bp from pter |
End:
|
17,276,943 bp from pter |
Size:
|
59,275 bases |
Orientation:
|
plus strand |
|
Proteins
for BASP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BASP1_HUMAN, P80723 (See
protein sequence)Recommended Name: Brain acid soluble protein 1 Size: 227 amino acids; 22693 Da
Subcellular location: Cell membrane; Lipid-anchor. Cell projection, growth cone. Note=Associated with the membranes ofgrowth cones that form the tips of elongating axons
Mass spectrometry: Mass=22780; Method=Electrospray; Range=2-227; Source=PubMed:9310187;
Secondary accessions: B4DJA8 D3DTD5 O43596 Q5U0S0 Q9BWA5Alternative splicing: 2 isoforms: P80723-1 P80723-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for BASP1: NX_P80723
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P80723
BASP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001258535.1 NP_006308.3
ENSEMBL proteins: ENSP00000319281
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
BASP1 for ontologies About GeneDecksing
BASP1 Antibody Products:
Assay Products for BASP1: |
Protein
Domains /
Families
for BASP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BASP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P80723ProtoNet protein and cluster: P80723 1 Blocks protein family: IPB008408 Brain acid soluble protein 1
UniProtKB/Swiss-Prot: BASP1_HUMAN, P80723Similarity: Belongs to the BASP1 family |
Function
for BASP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for BASP1:brain acid-soluble protein 1,myristoylated protein,abundantly expressed in various tissue at nerve endings,alsoexpressed in testis,kidney,lymphoid organs
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BASP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BASP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BASP1 (NM_006317) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BASP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BASP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BASP1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
BASP1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for BASP1:
Animal Models:
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Basp1):
BASP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for BASP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BASP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/7 Interacting proteins for BASP1 (P807232, 3 ENSP000003192814) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007356 | thorax and anterior abdomen determination |
ISS | -- | | GO:0008406 | gonad development |
ISS | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
IMP | 14701728 | | GO:0060231 | mesenchymal to epithelial transition |
ISS | -- | | GO:0060421 | positive regulation of heart growth |
ISS | -- |
BASP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for BASP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
BASP1 for compounds About GeneDecksing
 Browse Tocris compounds for BASP1
5 Novoseek chemical compound relationships for BASP1 gene About this table
Search CenterWatch for drugs/clinical trials and news about BASP1
|
Transcripts
for BASP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BASP1 gene (2 alternative transcripts): NM_001271606.1 NM_006317.4 Unigene Clusters for BASP1: Brain abundant, membrane attached signal protein 1 Hs.201641 [show with all ESTs], Hs.744329 [show with all ESTs]Unigene Representative Sequences: NM_006317, BT0193411 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000322611(uc003jfx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BASP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BASP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BASP1 (NM_006317) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BASP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BASP1 |
Additional cDNA sequence: BT019340.1 BT019341.1 14 DOTS entries: DT.75140733 DT.100008434 DT.86994075 DT.100838975 DT.120864208 DT.97846240 DT.99974098 DT.100838974 DT.40116895 DT.100037262 DT.100838966 DT.100838968 DT.100838971 DT.92440002 24/312 AceView cDNA sequences (see all 312): NM_006317 AI972825 BC000518 AI168203 BQ959037 AA340213 CB052939 BQ918780 BM560987 AW075252 BQ672186 AI816042 AA321448 AW590743 AI355907 BU149333 BM423670 AI391550 BE675194 BM810035 AI418023 BU738876 AJ705304 BQ942001
GeneLoc Exon Structure
|
Expression
for BASP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BASP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCGTGGTTG
About this image
See BASP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BASP1
SOURCE GeneReport for Unigene clusters: Hs.201641 Hs.744329
UniProtKB/Swiss-Prot: BASP1_HUMAN, P80723Tissue specificity: Brain
SABiosciences Expression via Pathway-Focused PCR Array including BASP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BASP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BASP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BASP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BASP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BASP1 |
Orthologs
for BASP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for BASP1 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for BASP1 (if available)
TreeFam Gene Tree for BASP1 (if available) |
Paralogs
for BASP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BASP1 gene
- GAP432
BASP1 for paralogs About GeneDecksing
|
Genomic Variants
for BASP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BASP1 (17217669 - 17276943 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BASP1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BASP1 |
|
Disorders
/ Diseases
for BASP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BASP1 for disorders About GeneDecksing
OMIM gene information: 605940
OMIM disorders: --
8  diseases for BASP1: About MalaCardsneuronitis wilms tumor bipolar disorder parkinson's disease
hepatocellular carcinoma cholesterol schizophrenia carcinoma
Export disorders for BASP1 gene to outside databases
|
Publications
for BASP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BASP1 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with BASP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The BASP1 family of myristoylated proteins abundant in axonal termini. Primary structure analysis and physico-chemical properties. (PubMed id 9310187)1, 2, 3, 9 Mosevitsky M.I.... Zakharov V.V. (1997)
- Characterization of bovine and human cDNAs encoding NAP-22 (22 kDa neuronal tissue-enriched acidic protein) homologs. (PubMed id 9749536)1, 2, 3, 9 Park S.... Yoon J. (1998)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation. (PubMed id 19050011)1, 9 Green L.M....Roberts S.G. (2009)
- BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1. (PubMed id 14701728)1, 9 Carpenter B....Roberts S.G. (2004)
- Assignment of brain acid-soluble protein 1 (BASP1) to human chromosome 5p15.1-->p14, differential expression in human cancer cell lines as a result of alterations in gene dosage. (PubMed id 10965107)1, 9 Fitzgibbon J....Gupta R.K. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for BASP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BASP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BASP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BASP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BASP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BASP1 gene:
Search GeneIP for patents involving BASP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BASP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BASP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BASP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BASP1 | | | OriGene Protein Over-expression Lysate for BASP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BASP1 | | OriGene 3'-UTR Clone for BASP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BASP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BASP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BASP1 | | OriGene Custom Protein Services for BASP1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BASP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BASP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BASP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BASP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BASP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BASP1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for BASP1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | BASP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BASP1 |
|  |  |  | | | | ThermoFisher Antibodies for BASP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BASP1 |
|
|
|
|
