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Aliases for BASP1 Gene

Aliases for BASP1 Gene

  • Brain Abundant Membrane Attached Signal Protein 1 2 3
  • Brain Abundant, Membrane Attached Signal Protein 1 2 3 5
  • 22 KDa Neuronal Tissue-Enriched Acidic Protein 3 4
  • Neuronal Axonal Membrane Protein NAP-22 3 4
  • NAP22 3 4
  • Neuronal Tissue-Enriched Acidic Protein 3
  • Brain Acid-Soluble Protein 1 3
  • CAP-23 3
  • NAP-22 3
  • CAP23 3

External Ids for BASP1 Gene

Previous GeneCards Identifiers for BASP1 Gene

  • GC05P017265
  • GC05P017495
  • GC05P017270
  • GC05P017217

Summaries for BASP1 Gene

Entrez Gene Summary for BASP1 Gene

  • This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-terminal myristoylation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2012]

GeneCards Summary for BASP1 Gene

BASP1 (Brain Abundant Membrane Attached Signal Protein 1) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding and transcription corepressor activity.

Gene Wiki entry for BASP1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BASP1 Gene

Genomics for BASP1 Gene

Regulatory Elements for BASP1 Gene

Enhancers for BASP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BASP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BASP1 Gene

17,065,598 bp from pter
17,276,845 bp from pter
211,248 bases
Plus strand

Genomic View for BASP1 Gene

Genes around BASP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BASP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BASP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BASP1 Gene

Proteins for BASP1 Gene

  • Protein details for BASP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Brain acid soluble protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DJA8
    • D3DTD5
    • O43596
    • Q5U0S0
    • Q9BWA5

    Protein attributes for BASP1 Gene

    227 amino acids
    Molecular mass:
    22693 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BASP1 Gene


neXtProt entry for BASP1 Gene

Proteomics data for BASP1 Gene at MOPED

Post-translational modifications for BASP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BASP1 Gene

Antibody Products

No data available for DME Specific Peptides for BASP1 Gene

Domains & Families for BASP1 Gene

Protein Domains for BASP1 Gene


Suggested Antigen Peptide Sequences for BASP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BASP1 family.
  • Belongs to the BASP1 family.
genes like me logo Genes that share domains with BASP1: view

No data available for Gene Families for BASP1 Gene

Function for BASP1 Gene

Molecular function for BASP1 Gene

GENATLAS Biochemistry:
brain acid-soluble protein 1,myristoylated protein,abundantly expressed in various tissue at nerve endings,also expressed in testis,kidney,lymphoid organs
genes like me logo Genes that share phenotypes with BASP1: view

Animal Models for BASP1 Gene

MGI Knock Outs for BASP1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BASP1 Gene

Localization for BASP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BASP1 Gene

Cell membrane; Lipid-anchor. Cell projection, growth cone. Note=Associated with the membranes of growth cones that form the tips of elongating axons.

Subcellular locations from

Jensen Localization Image for BASP1 Gene COMPARTMENTS Subcellular localization image for BASP1 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for BASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 14701728
GO:0016607 nuclear speck ISS --
GO:0031982 vesicle IDA 19190083
genes like me logo Genes that share ontologies with BASP1: view

Pathways & Interactions for BASP1 Gene

SuperPathways for BASP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008406 gonad development ISS --
GO:2001076 positive regulation of metanephric ureteric bud development ISS --
genes like me logo Genes that share ontologies with BASP1: view

No data available for Pathways by source and SIGNOR curated interactions for BASP1 Gene

Drugs & Compounds for BASP1 Gene

(2) Drugs for BASP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for BASP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BASP1: view

Transcripts for BASP1 Gene

Unigene Clusters for BASP1 Gene

Brain abundant, membrane attached signal protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BASP1 Gene

No ASD Table

Relevant External Links for BASP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BASP1 Gene

mRNA expression in normal human tissues for BASP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BASP1 Gene

This gene is overexpressed in Whole Blood (x12.0), Brain - Frontal Cortex (BA9) (x4.5), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Protein differential expression in normal tissues from HIPED for BASP1 Gene

This gene is overexpressed in Nasal epithelium (10.7), Lavage (10.6), Frontal cortex (10.3), and Brain (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BASP1 Gene

SOURCE GeneReport for Unigene cluster for BASP1 Gene Hs.201641

mRNA Expression by UniProt/SwissProt for BASP1 Gene

Tissue specificity: Brain.
genes like me logo Genes that share expression patterns with BASP1: view

Protein tissue co-expression partners for BASP1 Gene

Primer Products

Orthologs for BASP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BASP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BASP1 35
  • 78.77 (n)
  • 74.53 (a)
(Canis familiaris)
Mammalia BASP1 35
  • 79.19 (n)
  • 73.83 (a)
BASP1 36
  • 62 (a)
(Mus musculus)
Mammalia Basp1 35
  • 72.89 (n)
  • 67.94 (a)
Basp1 16
Basp1 36
  • 71 (a)
(Pan troglodytes)
Mammalia BASP1 35
  • 99.41 (n)
  • 99.56 (a)
BASP1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC100910172 35
  • 66.35 (n)
  • 55.02 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
-- 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia BASP1 36
  • 79 (a)
(Gallus gallus)
Aves BASP1 36
  • 61 (a)
(Anolis carolinensis)
Reptilia BASP1 36
  • 60 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20894 35
Species with no ortholog for BASP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BASP1 Gene

Gene Tree for BASP1 (if available)
Gene Tree for BASP1 (if available)

Paralogs for BASP1 Gene

No data available for Paralogs for BASP1 Gene

Variants for BASP1 Gene

Sequence variations from dbSNP and Humsavar for BASP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3733748 - 17,275,443(-) CAGCC(A/G)CCGCG reference, missense
rs12666 -- 17,275,580(-) AGCAG(A/C)TTTGG reference, missense
rs2624415 -- 17,221,527(+) CTTTC(C/T)CTTCT intron-variant
rs904862 -- 17,234,110(+) TGCAC(A/G)ACAGA intron-variant
rs2650929 -- 17,266,923(+) AATGG(G/T)GATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BASP1 Gene

Variant ID Type Subtype PubMed ID
nsv880277 CNV Gain 21882294
nsv830218 CNV Loss 17160897
nsv4738 CNV Loss 18451855
nsv521697 CNV Loss 19592680
nsv823015 CNV Gain 20364138
esv2667347 CNV Deletion 23128226

Variation tolerance for BASP1 Gene

Residual Variation Intolerance Score: 78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BASP1 Gene

Disorders for BASP1 Gene

Relevant External Links for BASP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BASP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BASP1 Gene

Publications for BASP1 Gene

  1. The BASP1 family of myristoylated proteins abundant in axonal termini. Primary structure analysis and physico-chemical properties. (PMID: 9310187) Mosevitsky M.I. … Zakharov V.V. (Biochimie 1997) 2 3 4 23 67
  2. Characterization of bovine and human cDNAs encoding NAP-22 (22 kDa neuronal tissue-enriched acidic protein) homologs. (PMID: 9749536) Park S. … Yoon J. (Mol. Cells 1998) 2 3 23
  3. Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation. (PMID: 19050011) Green L.M. … Roberts S.G. (Nucleic Acids Res. 2009) 3 23
  4. BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1. (PMID: 14701728) Carpenter B. … Roberts S.G. (Mol. Cell. Biol. 2004) 3 23
  5. Assignment of brain acid-soluble protein 1 (BASP1) to human chromosome 5p15.1-->p14, differential expression in human cancer cell lines as a result of alterations in gene dosage. (PMID: 10965107) Fitzgibbon J. … Gupta R.K. (Cytogenet. Cell Genet. 2000) 3 23

Products for BASP1 Gene

Sources for BASP1 Gene