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Aliases for BASP1 Gene

Aliases for BASP1 Gene

  • Brain Abundant, Membrane Attached Signal Protein 1 2 3
  • NAP22 3 4 6
  • 22 KDa Neuronal Tissue-Enriched Acidic Protein 3 4
  • Neuronal Axonal Membrane Protein NAP-22 3 4
  • CAP23 3 6
  • Neuronal Tissue-Enriched Acidic Protein 3
  • Brain Acid Soluble Protein 1 3
  • Brain Acid-Soluble Protein 1 3
  • CAP-23 3
  • NAP-22 3

External Ids for BASP1 Gene

Previous GeneCards Identifiers for BASP1 Gene

  • GC05P017265
  • GC05P017495
  • GC05P017270
  • GC05P017217

Summaries for BASP1 Gene

Entrez Gene Summary for BASP1 Gene

  • This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-terminal myristoylation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2012]

GeneCards Summary for BASP1 Gene

BASP1 (Brain Abundant, Membrane Attached Signal Protein 1) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor activity and protein domain specific binding.

Gene Wiki entry for BASP1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BASP1 Gene

Genomics for BASP1 Gene

Regulatory Elements for BASP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BASP1 Gene

17,065,598 bp from pter
17,276,845 bp from pter
211,248 bases
Plus strand

Genomic View for BASP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BASP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BASP1 Gene

Proteins for BASP1 Gene

  • Protein details for BASP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Brain acid soluble protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DJA8
    • D3DTD5
    • O43596
    • Q5U0S0
    • Q9BWA5

    Protein attributes for BASP1 Gene

    227 amino acids
    Molecular mass:
    22693 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BASP1 Gene


neXtProt entry for BASP1 Gene

Proteomics data for BASP1 Gene at MOPED

Post-translational modifications for BASP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BASP1 Gene

Antibody Products

No data available for DME Specific Peptides for BASP1 Gene

Domains for BASP1 Gene

Protein Domains for BASP1 Gene


Suggested Antigen Peptide Sequences for BASP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P80723
  • Belongs to the BASP1 family.
genes like me logo Genes that share domains with BASP1: view

No data available for Gene Families for BASP1 Gene

Function for BASP1 Gene

Molecular function for BASP1 Gene

GENATLAS Biochemistry:
brain acid-soluble protein 1,myristoylated protein,abundantly expressed in various tissue at nerve endings,also expressed in testis,kidney,lymphoid organs

Gene Ontology (GO) - Molecular Function for BASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IMP 14701728
GO:0005515 protein binding IPI 19050011
GO:0019904 protein domain specific binding IPI 14701728
GO:0044212 transcription regulatory region DNA binding ISS --
genes like me logo Genes that share ontologies with BASP1: view
genes like me logo Genes that share phenotypes with BASP1: view

Animal Model Products

miRNA for BASP1 Gene

miRTarBase miRNAs that target BASP1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BASP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BASP1 Gene

Localization for BASP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BASP1 Gene

Cell membrane; Lipid-anchor. Cell projection, growth cone. Note=Associated with the membranes of growth cones that form the tips of elongating axons.

Subcellular locations from

Jensen Localization Image for BASP1 Gene COMPARTMENTS Subcellular localization image for BASP1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for BASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14701728
GO:0005737 cytoplasm IDA 14701728
GO:0005856 cytoskeleton TAS 9749536
GO:0005886 plasma membrane IDA --
GO:0008180 colocalizes_with COP9 signalosome IDA 18850735
genes like me logo Genes that share ontologies with BASP1: view

Pathways for BASP1 Gene

SuperPathways for BASP1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BASP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007356 thorax and anterior abdomen determination ISS --
GO:0008406 gonad development ISS --
GO:0021762 substantia nigra development IEP 22926577
GO:0045892 negative regulation of transcription, DNA-templated IMP 14701728
GO:0060231 mesenchymal to epithelial transition ISS --
genes like me logo Genes that share ontologies with BASP1: view

No data available for Pathways by source for BASP1 Gene

Compounds for BASP1 Gene

(5) Novoseek inferred chemical compound relationships for BASP1 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylethanolamine 52.9 4
phosphatidylcholine 40.5 2
cholesterol 39.7 19
lipid 29.7 4
phospholipid 19.3 1
genes like me logo Genes that share compounds with BASP1: view

Transcripts for BASP1 Gene

mRNA/cDNA for BASP1 Gene

Unigene Clusters for BASP1 Gene

Brain abundant, membrane attached signal protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BASP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BASP1 Gene

No ASD Table

Relevant External Links for BASP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BASP1 Gene

mRNA expression in normal human tissues for BASP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BASP1 Gene

This gene is overexpressed in Whole Blood (12.0), Brain - Frontal Cortex (BA9) (4.5), and Brain - Anterior cingulate cortex (BA24) (4.3).

Protein differential expression in normal tissues for BASP1 Gene

This gene is overexpressed in Nasal epithelium (10.7), Lavage (10.6), Frontal cortex (10.3), and Brain (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BASP1 Gene

SOURCE GeneReport for Unigene cluster for BASP1 Gene Hs.201641

mRNA Expression by UniProt/SwissProt for BASP1 Gene

Tissue specificity: Brain
genes like me logo Genes that share expressions with BASP1: view

Expression partners for BASP1 Gene

In Situ Assay Products

Orthologs for BASP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BASP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BASP1 35
  • 78.77 (n)
  • 74.53 (a)
(Canis familiaris)
Mammalia BASP1 35
  • 79.19 (n)
  • 73.83 (a)
BASP1 36
  • 62 (a)
(Mus musculus)
Mammalia Basp1 35
  • 72.89 (n)
  • 67.94 (a)
Basp1 16
Basp1 36
  • 71 (a)
(Pan troglodytes)
Mammalia BASP1 35
  • 99.41 (n)
  • 99.56 (a)
BASP1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC100910172 35
  • 66.35 (n)
  • 55.02 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
-- 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia BASP1 36
  • 79 (a)
(Gallus gallus)
Aves BASP1 36
  • 61 (a)
(Anolis carolinensis)
Reptilia BASP1 36
  • 60 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20894 35
Species with no ortholog for BASP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BASP1 Gene

Gene Tree for BASP1 (if available)
Gene Tree for BASP1 (if available)

Paralogs for BASP1 Gene

No data available for Paralogs for BASP1 Gene

Variants for BASP1 Gene

Sequence variations from dbSNP and Humsavar for BASP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs12666 -- 17,275,580(-) AGCAG(A/C)TTTGG reference, missense
rs167237 -- 17,269,253(+) GAACA(A/T)GATTT intron-variant
rs186145 -- 17,266,951(+) TTAAG(G/T)GGTTG intron-variant
rs212943 -- 17,245,854(-) TGGTT(C/T)TGAAT intron-variant
rs298523 -- 17,230,634(+) TCTCA(G/T)CTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BASP1 Gene

Variant ID Type Subtype PubMed ID
nsv880277 CNV Gain 21882294
nsv830218 CNV Loss 17160897
nsv4738 CNV Loss 18451855
nsv521697 CNV Loss 19592680
nsv823015 CNV Gain 20364138
esv2667347 CNV Deletion 23128226

Relevant External Links for BASP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BASP1 Gene

Disorders for BASP1 Gene

No disorders were found for BASP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for BASP1 Gene

Publications for BASP1 Gene

  1. The BASP1 family of myristoylated proteins abundant in axonal termini. Primary structure analysis and physico-chemical properties. (PMID: 9310187) Mosevitsky M.I. … Zakharov V.V. (Biochimie 1997) 2 3 4 23
  2. Characterization of bovine and human cDNAs encoding NAP-22 (22 kDa neuronal tissue-enriched acidic protein) homologs. (PMID: 9749536) Park S. … Yoon J. (Mol. Cells 1998) 2 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1. (PMID: 14701728) Carpenter B. … Roberts S.G. (Mol. Cell. Biol. 2004) 3 23
  5. Assignment of brain acid-soluble protein 1 (BASP1) to human chromosome 5p15.1-->p14, differential expression in human cancer cell lines as a result of alterations in gene dosage. (PMID: 10965107) Fitzgibbon J. … Gupta R.K. (Cytogenet. Cell Genet. 2000) 3 23

Products for BASP1 Gene

Sources for BASP1 Gene

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