Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BARX2 Gene

protein-coding   GIFtS: 51
GCID: GC11P129279

BARX Homeobox 2

(Previous name: BarH-like homeobox 2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
BARX Homeobox 21 2
BarH-Like Homeobox 21 2
Homeobox Protein BarH-Like 22

External Ids:    HGNC: 9561   Entrez Gene: 85382   Ensembl: ENSG000000430397   OMIM: 6048235   UniProtKB: Q9UMQ33   

Export aliases for BARX2 gene to outside databases

Previous GC identifers: GC11P131246 GC11P130758 GC11P128783 GC11P128751 GC11P125197


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for BARX2 Gene:
This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been
shown to influence cellular processes that control cell adhesion and remodeling of the actin cytoskeleton in
myoblast fusion and chondrogenesis. The encoded protein may also play a role in cancer progression. (provided by
RefSeq, Jul 2008)

GeneCards Summary for BARX2 Gene:
BARX2 (BARX homeobox 2) is a protein-coding gene. Diseases associated with BARX2 include breast cancer. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DLX2.

UniProtKB/Swiss-Prot: BARX2_HUMAN, Q9UMQ3
Function: Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the
expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and
peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the BARX2 gene promoter:
         SRF   SRF (504 AA)   SEF-1 (1)   MyoD   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBARX2 promoter sequence
   Search Chromatin IP Primers for BARX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BARX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q25   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q24.3

BARX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BARX2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P129279:  view genomic region     (about GC identifiers)

Start:
129,245,835 bp from pter      End:
129,322,174 bp from pter
Size:
76,340 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BARX2_HUMAN, Q9UMQ3 (See protein sequence)
Recommended Name: Homeobox protein BarH-like 2  
Size: 279 amino acids; 31188 Da
Sequence caution: Sequence=AAC04705.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAC04705.1; Type=Frameshift; Positions=11; Sequence=AAF09453.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=AAF09453.1; Type=Frameshift; Positions=11;
Secondary accessions: O43518 Q6NT51

Explore the universe of human proteins at neXtProt for BARX2: NX_Q9UMQ3

Explore proteomics data for BARX2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys23
  • Modification sites at PhosphoSitePlus

  • See BARX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003649.2  
    ENSEMBL proteins: 
     ENSP00000281437   ENSP00000451113   ENSP00000450418  

    BARX2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for BARX2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for BARX2
    GenScript Custom Purified and Recombinant Proteins Services for BARX2
    Novus Biologicals BARX2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BARX2

    BARX2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for BARX2
    Novus Biologicals BARX2 Antibodies
    Search for Antibodies for BARX2 at Abcam
    Cloud-Clone Corp. Antibodies for BARX2
    ThermoFisher Antibodies for BARX2
    LSBio Antibodies in human, mouse, rat for BARX2

    BARX2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BARX2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BARX2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BARX2
    Cloud-Clone Corp. CLIAs for BARX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    NKL: Homeoboxes / ANTP class : NKL subclass

    5 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9UMQ3

    ProtoNet protein and cluster: Q9UMQ3

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: BARX2_HUMAN, Q9UMQ3
    Similarity: Belongs to the BAR homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    BARX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BARX2_HUMAN, Q9UMQ3
    Function: Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the
    expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and
    peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By
    similarity)

         Genatlas biochemistry entry for BARX2:
    Bar H-like homeobox 2,expressed in craniofacial structures during development

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding IDA10854790
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
         
    BARX2 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Barx2):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  integument  mortality/aging 
     muscle  pigmentation  skeleton  vision/eye 

    BARX2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BARX2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BARX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BARX2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BARX2

    miRNA
    Products:
        
    miRTarBase miRNAs that target BARX2:
    hsa-mir-769-5p (MIRT039194), hsa-mir-335-5p (MIRT017365)

    Block miRNA regulation of human, mouse, rat BARX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BARX2 (see all 34):
    hsa-miR-302d hsa-miR-520e hsa-miR-1321 hsa-miR-519a hsa-miR-105 hsa-miR-124 hsa-miR-372 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidBARX2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BARX2
    Predesigned siRNA for gene silencing in human, mouse, rat BARX2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BARX2

    Clone
    Products:
         
    OriGene clones in human, mouse for BARX2 (see all 6)
    OriGene ORF clones in mouse, rat for BARX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BARX2 (NM_003658)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BARX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BARX2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BARX2
    Browse ESI BIO Cell Lines and PureStem Progenitors for BARX2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BARX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    BARX2_HUMAN, Q9UMQ3: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--

    BARX2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BARX2
    Interactions:

        Search GeneGlobe Interaction Network for BARX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for BARX2 (Q9UMQ33 ENSP000002814374) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    SRFP118313, ENSP000002653544I2D: score=2 STRING: ENSP00000265354
    ATF2P153363, ENSP000002641104I2D: score=2 STRING: ENSP00000264110
    CREB1P162203, ENSP000003876994I2D: score=3 STRING: ENSP00000387699
    FOSP011003, ENSP000003062454I2D: score=2 STRING: ENSP00000306245
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001502cartilage condensation IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0014902myotube differentiation IEA--

    BARX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BARX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BARX2 gene: 
    NM_003658.4  

    Unigene Cluster for BARX2:

    BARX homeobox 2
    Hs.591944  [show with all ESTs]
    Unigene Representative Sequence: NM_003658
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281437(uc001qfc.4) ENST00000605151 ENST00000526127 ENST00000531946

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BARX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BARX2 (see all 34):
    hsa-miR-302d hsa-miR-520e hsa-miR-1321 hsa-miR-519a hsa-miR-105 hsa-miR-124 hsa-miR-372 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidBARX2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BARX2
    Predesigned siRNA for gene silencing in human, mouse, rat BARX2
    Clone
    Products:
         
    OriGene clones in human, mouse for BARX2 (see all 6)
    OriGene ORF clones in mouse, rat for BARX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BARX2 (NM_003658)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BARX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BARX2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for BARX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BARX2
      QuantiTect SYBR Green Assays in human, mouse, rat BARX2
      QuantiFast Probe-based Assays in human, mouse, rat BARX2

    Additional mRNA sequence: 

    AF031924.1 AJ243512.1 BC069378.1 BC111432.1 BC111572.1 

    2 DOTS entries:

    DT.40127734  DT.91818059 

    21 AceView cDNA sequences:

    AI823489 NM_003658 AI696665 AI370544 BC069378 BG679733 AI733496 AF031924 
    AK022187 AI675861 AU121450 AJ243512 CD722863 BX096859 AI915798 BF476388 
    AA991537 AI792204 BF510404 BF511228 AU147258 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BARX2 expression in normal human tissues (normalized intensities)      BARX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTAGGGTTC
    BARX2 Expression
    About this image


    BARX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Limb (Muscoskeletal System)
             Autopod
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Esophagus (Gastrointestinal Tract)
     
     Larynx (Respiratory System)
    BARX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BARX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591944

    UniProtKB/Swiss-Prot: BARX2_HUMAN, Q9UMQ3
    Tissue specificity: Highly expressed in adult salivary gland and at much lower levels in mammary gland, kidney and
    placenta

        Custom PCR Arrays for BARX2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for BARX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BARX2
    QuantiTect SYBR Green Assays in human, mouse, rat BARX2
    QuantiFast Probe-based Assays in human, mouse, rat BARX2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BARX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for BARX2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Barx21 , 5 BarH-like homeobox 21, 5 87.1(n)1
    88.53(a)1
      9 (17.25 cM)5
    120231  NM_013800.21  NP_038828.21 
     318460975 
    chicken
    (Gallus gallus)
    Aves BARX21 BARX homeobox 2 75.78(n)
    80.47(a)
      395714  NM_204896.1  NP_990227.1 
    lizard
    (Anolis carolinensis)
    Reptilia BARX26
    BARX homeobox 2
    72(a)
    1 ↔ 1
    GL343197.1(3831135-3845558)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia barx21 BARX homeobox 2 70.56(n)
    77.82(a)
      100488405  XM_002934879.2  XP_002934925.2 
    zebrafish
    (Danio rerio)
    Actinopterygii barx21 BarH-like homeobox 2 72.15(n)
    76.62(a)
      100002200  XM_001342008.4  XP_001342044.1 


    ENSEMBL Gene Tree for BARX2 (if available)
    TreeFam Gene Tree for BARX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for BARX2 gene
    DLX22  BARX12  GBX12  NKX1-12  VENTX2  GBX22  BARHL12  BARHL22  
    MNX12  DLX12  DLX32  LBX22  NKX1-22  BSX2  DLX52  DLX62  
    DLX42  LBX12  MSX22  MSX12  
    9 SIMAP similar genes for BARX2 using alignment to 3 protein entries:     BARX2_HUMAN (see all proteins):
    NKX2-5    HOXA4    BARX1    HMX2    MNX1    HOXB1
    HLX    DLX1    DLX6

    BARX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BARX2 (see all 1603)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846398791,2
    --125195594(+) CTCGGC/GAGACT 1 -- us2k10--------
    rs3710310721,2
    C--125195624(+) AACCT-/GGGGGG 1 -- us2k10--------
    rs785298481,2
    C--125195641(+) TTGCAA/GTGAGG 1 -- us2k10--------
    rs30863101,2
    F--125204193(+) GCTGG-/AATATGG
    T
    /TTAGAGGG
    TAGAG
    1 -- int14EU NA MN 380
    rs730249111,2
    C--129243975(+) GGCGTA/GTCCCT 1 -- us2k10--------
    rs1814864261,2
    --129244032(+) CCGCGC/GCCACC 1 -- us2k10--------
    rs1162307841,2
    C,F--129244287(+) GCTGCC/TGGAGG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1381292961,2
    --129244606(+) GTTTTC/TATAAA 1 -- us2k10--------
    rs2001814491,2
    --129244616(+) CAATG-/TTTTTA 1 -- us2k10--------
    rs1411483541,2
    C--129244620(+) AAAAA-/ACCGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BARX2 (129245835 - 129322174 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BARX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv546CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BARX2
    DNA2.0 Custom Variant and Variant Library Synthesis for BARX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604823    OMIM disorders: --

    1 disease for BARX2:    About MalaCards
    breast cancer


    BARX2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BARX2
    Human Genome Epidemiology (HuGE) Navigator: BARX2 (1 document)

    Export disorders for BARX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BARX2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with BARX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human BARX2 gene: genomic structure, chromosomal localization, and single nucleotide polymorphisms. (PubMed id 10644443)1, 2, 3 Hjalt T.A. and Murray J.C. (Genomics 1999)
    2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    3. Cloning and chromosomal localization of the human BARX2 homeobox protein gene. (PubMed id 10854790)1, 2 Krasner A.... Nelkin B.D. (Gene 2000)
    4. A genome-wide association search for type 2 diabetes genes in African Americans. (PubMed id 22238593)1 Palmer N.D....Sladek R. (PLoS ONE 2012)
    5. Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer. (PubMed id 22383897)1 Long J....Zheng W. (PLoS Genet. 2012)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Identification of novel binding elements and gene targets for the homeodomain protein BARX2. (PubMed id 14744868)1 Stevens T.A....Meech R. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8538 HGNC: 956 AceView: BARX2 Ensembl:ENSG00000043039 euGenes: HUgn8538
    ECgene: BARX2 H-InvDB: BARX2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BARX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BARX2 gene:
    Search GeneIP for patents involving BARX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for BARX2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for BARX2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for BARX2  
     OriGene qSTAR qPCR primer pairs in human, mouse for BARX2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for BARX2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BARX2   OriGene Custom Protein Services for BARX2  

     
     
     Block miRNA regulation of human, mouse, rat BARX2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BARX2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BARX2 Predesigned siRNA for gene silencing in human, mouse, rat BARX2
     QuantiFast Probe-based Assays in human, mouse, rat BARX2 QuantiTect SYBR Green Assays in human, mouse, rat BARX2
     Custom PCR Arrays for BARX2 Search Chromatin IP Primers for BARX2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BARX2  Search GeneGlobe Interaction Network for BARX2
     Regulatory tfbs in BARX2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for BARX2 GenScript cDNA clones with any tag delivered in your preferred vector for BARX2
     GenScript Custom Assay Services for BARX2 GenScript Custom overexpressing Cell Line Services for BARX2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for BARX2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BARX2 antibodies
     BARX2 proteins
     Search for Antibodies for BARX2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for BARX2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for BARX2
     Antibodies for BARX2
     ELISAs for BARX2
     CLIAs for BARX2



     Browse ESI BIO Cell Lines and PureStem Progenitors for BARX2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BARX2
     SwitchGear 3'UTR luciferase reporter plasmids for BARX2
     SwitchGear Promoter luciferase reporter plasmids for BARX2
     ThermoFisher Antibodies for BARX2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BARX2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BARX2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BARX2
     LSBio Antibodies in human, mouse, rat for BARX2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BARX2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4