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Aliases for BARX2 Gene

Aliases for BARX2 Gene

  • BARX Homeobox 2 2 3
  • BarH-Like Homeobox 2 2

External Ids for BARX2 Gene

Summaries for BARX2 Gene

Entrez Gene Summary for BARX2 Gene

  • This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been shown to influence cellular processes that control cell adhesion and remodeling of the actin cytoskeleton in myoblast fusion and chondrogenesis. The encoded protein may also play a role in cancer progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for BARX2 Gene

BARX2 (BARX Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is DLX5.

UniProtKB/Swiss-Prot for BARX2 Gene

  • Transcription factor. Binds optimally to the DNA consensus sequence 5-YYTAATGRTTTTY-3. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BARX2 Gene

Genomics for BARX2 Gene

Genomic Location for BARX2 Gene

Start:
129,375,940 bp from pter
End:
129,452,279 bp from pter
Size:
76,340 bases
Orientation:
Plus strand

Genomic View for BARX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BARX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BARX2 Gene

Regulatory Elements for BARX2 Gene

Proteins for BARX2 Gene

  • Protein details for BARX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMQ3-BARX2_HUMAN
    Recommended name:
    Homeobox protein BarH-like 2
    Protein Accession:
    Q9UMQ3
    Secondary Accessions:
    • O43518
    • Q6NT51

    Protein attributes for BARX2 Gene

    Size:
    279 amino acids
    Molecular mass:
    31188 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC04705.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC04705.1; Type=Frameshift; Positions=11; Evidence={ECO:0000305}; Sequence=AAF09453.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF09453.1; Type=Frameshift; Positions=11; Evidence={ECO:0000305};

neXtProt entry for BARX2 Gene

Proteomics data for BARX2 Gene at MOPED

Post-translational modifications for BARX2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys23

Other Protein References for BARX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BARX2 Gene

Domains for BARX2 Gene

Gene Families for BARX2 Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

UniProtKB/Swiss-Prot:

BARX2_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • Q9UMQ3
Family:
  • Belongs to the BAR homeobox family.:
    • Q9UMQ3
genes like me logo Genes that share domains with BARX2: view

Function for BARX2 Gene

Molecular function for BARX2 Gene

GENATLAS Biochemistry: Bar H-like homeobox 2,expressed in craniofacial structures during development
UniProtKB/Swiss-Prot Function: Transcription factor. Binds optimally to the DNA consensus sequence 5-YYTAATGRTTTTY-3. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity).

Gene Ontology (GO) - Molecular Function for BARX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP 14744868
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP 14744868
GO:0003677 DNA binding IDA 10854790
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
genes like me logo Genes that share ontologies with BARX2: view
genes like me logo Genes that share phenotypes with BARX2: view

miRNA for BARX2 Gene

miRTarBase miRNAs that target BARX2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BARX2 Gene

Localization for BARX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BARX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BARX2 Gene COMPARTMENTS Subcellular localization image for BARX2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for BARX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion --
genes like me logo Genes that share ontologies with BARX2: view

Pathways for BARX2 Gene

SuperPathways for BARX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BARX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001502 cartilage condensation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0014902 myotube differentiation IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 14744868
genes like me logo Genes that share ontologies with BARX2: view

No data available for Pathways by source for BARX2 Gene

Transcripts for BARX2 Gene

mRNA/cDNA for BARX2 Gene

Unigene Clusters for BARX2 Gene

BARX homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BARX2 Gene

No ASD Table

Relevant External Links for BARX2 Gene

GeneLoc Exon Structure for
BARX2
ECgene alternative splicing isoforms for
BARX2

Expression for BARX2 Gene

mRNA expression in normal human tissues for BARX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BARX2 Gene

This gene is overexpressed in Esophagus - Mucosa (17.0), Minor Salivary Gland (11.1), Vagina (7.1), and Skin - Not Sun Exposed (Suprapubic) (4.2).

SOURCE GeneReport for Unigene cluster for BARX2 Gene Hs.591944

mRNA Expression by UniProt/SwissProt for BARX2 Gene

Q9UMQ3-BARX2_HUMAN
Tissue specificity: Highly expressed in adult salivary gland and at much lower levels in mammary gland, kidney and placenta
genes like me logo Genes that share expressions with BARX2: view

Orthologs for BARX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BARX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BARX2 36
  • 99.88 (n)
  • 100 (a)
BARX2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BARX2 36
  • 90.17 (n)
  • 88.13 (a)
BARX2 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BARX2 36
  • 90.8 (n)
  • 92.47 (a)
BARX2 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Barx2 36
  • 87.1 (n)
  • 88.53 (a)
Barx2 16
Barx2 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BARX2 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BARX2 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Barx2 36
  • 85.19 (n)
  • 88.89 (a)
chicken
(Gallus gallus)
Aves BARX2 36
  • 75.78 (n)
  • 80.47 (a)
BARX2B 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BARX2 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia barx2 36
  • 70.56 (n)
  • 77.82 (a)
zebrafish
(Danio rerio)
Actinopterygii barx2 36
  • 72.15 (n)
  • 76.62 (a)
barx2 37
  • 68 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
OneToMany
Species with no ortholog for BARX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BARX2 Gene

ENSEMBL:
Gene Tree for BARX2 (if available)
TreeFam:
Gene Tree for BARX2 (if available)

Paralogs for BARX2 Gene

Selected SIMAP similar genes for BARX2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BARX2: view

Variants for BARX2 Gene

Sequence variations from dbSNP and Humsavar for BARX2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs752271 -- 129,437,790(+) GGGAG(A/G)CTGAG intron-variant
rs752450 -- 129,397,586(-) TTTAA(C/T)GAACT intron-variant
rs871640 -- 129,389,523(-) TAGCG(C/T)TGACC intron-variant
rs871641 -- 129,389,408(-) AACAA(C/T)TCACA intron-variant
rs903095 -- 129,387,241(+) GCTGT(C/G)AATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BARX2 Gene

Variant ID Type Subtype PubMed ID
nsv546 CNV Insertion 18451855

Relevant External Links for BARX2 Gene

HapMap Linkage Disequilibrium report
BARX2

Disorders for BARX2 Gene

Relevant External Links for BARX2

Genetic Association Database (GAD)
BARX2
Human Genome Epidemiology (HuGE) Navigator
BARX2
genes like me logo Genes that share disorders with BARX2: view

No data available for UniProtKB/Swiss-Prot for BARX2 Gene

Publications for BARX2 Gene

  1. The human BARX2 gene: genomic structure, chromosomal localization, and single nucleotide polymorphisms. (PMID: 10644443) Hjalt T.A. … Murray J.C. (Genomics 1999) 2 3 4
  2. Cloning and chromosomal localization of the human BARX2 homeobox protein gene. (PMID: 10854790) Krasner A. … Nelkin B.D. (Gene 2000) 3 4
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 49
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. A genome-wide association search for type 2 diabetes genes in African Americans. (PMID: 22238593) Palmer N.D. … Sladek R. (PLoS ONE 2012) 3

Products for BARX2 Gene

Sources for BARX2 Gene

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