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Aliases for BARX2 Gene

Aliases for BARX2 Gene

  • BARX Homeobox 2 2 3 5
  • BarH-Like Homeobox 2 2

External Ids for BARX2 Gene

Previous GeneCards Identifiers for BARX2 Gene

  • GC11P131246
  • GC11P130758
  • GC11P128783
  • GC11P128751
  • GC11P125197

Summaries for BARX2 Gene

Entrez Gene Summary for BARX2 Gene

  • This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been shown to influence cellular processes that control cell adhesion and remodeling of the actin cytoskeleton in myoblast fusion and chondrogenesis. The encoded protein may also play a role in cancer progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for BARX2 Gene

BARX2 (BARX Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is BARX1.

UniProtKB/Swiss-Prot for BARX2 Gene

  • Transcription factor. Binds optimally to the DNA consensus sequence 5-YYTAATGRTTTTY-3. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BARX2 Gene

Genomics for BARX2 Gene

Regulatory Elements for BARX2 Gene

Enhancers for BARX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F129374 1.4 FANTOM5 Ensembl ENCODE 20.7 +0.3 266 2.8 PKNOX1 ZNF48 ZNF2 RAD21 GLIS2 ZNF391 ZNF263 ZNF654 ZEB2 CBX8 BARX2 LOC646383 PIR38227
GH11F129380 0.9 FANTOM5 ENCODE 25.9 +5.2 5164 0.7 ZNF263 INSM2 FEZF1 ZNF843 OSR2 GATA3 ZNF366 FOS SP7 ZXDB BARX2 GC11M129375 GC11M129422
GH11F129636 1.2 FANTOM5 ENCODE 12.2 +265.2 265208 7.9 PKNOX1 ZFP64 INSM2 RAD21 ZNF366 SCRT2 ZNF391 FOS SP3 CEBPB BARX2 NFRKB LINC01395 GC11P129694
GH11F129750 1.2 Ensembl ENCODE 11 +375.6 375558 1.0 ELF3 ATF1 CBX3 FEZF1 ZNF48 RAD21 ZNF143 ZNF207 CREM MIXL1 BARX2 ARHGAP32 PIR39152 GC11M129755
GH11F129695 1.1 Ensembl ENCODE 11.3 +320.6 320616 1.3 CTCF ESRRA ZIC2 RAD21 ZFHX2 GATA3 GLIS2 CTBP1 ZBTB48 SCRT2 BARX2 GC11P129694 GC11P129702
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BARX2 on UCSC Golden Path with GeneCards custom track

Promoters for BARX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001773616 562 801 ELF3 PKNOX1 ZNF48 ZNF2 RAD21 GLIS2 ZNF263 ZNF654 ZEB2 GLIS1

Genomic Location for BARX2 Gene

Chromosome:
11
Start:
129,375,238 bp from pter
End:
129,452,279 bp from pter
Size:
77,042 bases
Orientation:
Plus strand

Genomic View for BARX2 Gene

Genes around BARX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BARX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BARX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BARX2 Gene

Proteins for BARX2 Gene

  • Protein details for BARX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMQ3-BARX2_HUMAN
    Recommended name:
    Homeobox protein BarH-like 2
    Protein Accession:
    Q9UMQ3
    Secondary Accessions:
    • O43518
    • Q6NT51

    Protein attributes for BARX2 Gene

    Size:
    279 amino acids
    Molecular mass:
    31188 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC04705.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC04705.1; Type=Frameshift; Positions=11; Evidence={ECO:0000305}; Sequence=AAF09453.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF09453.1; Type=Frameshift; Positions=11; Evidence={ECO:0000305};

neXtProt entry for BARX2 Gene

Post-translational modifications for BARX2 Gene

  • Ubiquitination at Lys 23
  • Modification sites at PhosphoSitePlus

Other Protein References for BARX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for BARX2

No data available for DME Specific Peptides for BARX2 Gene

Domains & Families for BARX2 Gene

Gene Families for BARX2 Gene

Suggested Antigen Peptide Sequences for BARX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UMQ3

UniProtKB/Swiss-Prot:

BARX2_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the BAR homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the BAR homeobox family.
genes like me logo Genes that share domains with BARX2: view

Function for BARX2 Gene

Molecular function for BARX2 Gene

GENATLAS Biochemistry:
Bar H-like homeobox 2,expressed in craniofacial structures during development
UniProtKB/Swiss-Prot Function:
Transcription factor. Binds optimally to the DNA consensus sequence 5-YYTAATGRTTTTY-3. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity).

Gene Ontology (GO) - Molecular Function for BARX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP 14744868
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IMP 14744868
GO:0003677 DNA binding IDA 10854790
GO:0003682 chromatin binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with BARX2: view
genes like me logo Genes that share phenotypes with BARX2: view

Animal Models for BARX2 Gene

MGI Knock Outs for BARX2:

Animal Model Products

miRNA for BARX2 Gene

miRTarBase miRNAs that target BARX2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BARX2 Gene

Localization for BARX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BARX2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BARX2 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for BARX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with BARX2: view

Pathways & Interactions for BARX2 Gene

SuperPathways for BARX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BARX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001502 cartilage condensation IEA,IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with BARX2: view

No data available for Pathways by source and SIGNOR curated interactions for BARX2 Gene

Transcripts for BARX2 Gene

mRNA/cDNA for BARX2 Gene

Unigene Clusters for BARX2 Gene

BARX homeobox 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BARX2 Gene

No ASD Table

Relevant External Links for BARX2 Gene

GeneLoc Exon Structure for
BARX2
ECgene alternative splicing isoforms for
BARX2

Expression for BARX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BARX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BARX2 Gene

This gene is overexpressed in Esophagus - Mucosa (x17.0), Minor Salivary Gland (x11.1), Vagina (x7.1), and Skin - Not Sun Exposed (Suprapubic) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of BARX2 Gene:

BARX2

SOURCE GeneReport for Unigene cluster for BARX2 Gene:

Hs.591944

mRNA Expression by UniProt/SwissProt for BARX2 Gene:

Q9UMQ3-BARX2_HUMAN
Tissue specificity: Highly expressed in adult salivary gland and at much lower levels in mammary gland, kidney and placenta.
genes like me logo Genes that share expression patterns with BARX2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BARX2 Gene

Orthologs for BARX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BARX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BARX2 34 35
  • 99.88 (n)
dog
(Canis familiaris)
Mammalia BARX2 34 35
  • 90.8 (n)
cow
(Bos Taurus)
Mammalia BARX2 34 35
  • 90.17 (n)
mouse
(Mus musculus)
Mammalia Barx2 34 16 35
  • 87.1 (n)
rat
(Rattus norvegicus)
Mammalia Barx2 34
  • 85.19 (n)
oppossum
(Monodelphis domestica)
Mammalia BARX2 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BARX2 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves BARX2 34
  • 75.78 (n)
BARX2B 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BARX2 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia barx2 34
  • 70.56 (n)
zebrafish
(Danio rerio)
Actinopterygii barx2 34 35
  • 72.15 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
Species where no ortholog for BARX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BARX2 Gene

ENSEMBL:
Gene Tree for BARX2 (if available)
TreeFam:
Gene Tree for BARX2 (if available)

Paralogs for BARX2 Gene

Paralogs for BARX2 Gene

(9) SIMAP similar genes for BARX2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BARX2: view

Variants for BARX2 Gene

Sequence variations from dbSNP and Humsavar for BARX2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10160233 -- 129,407,005(+) CCTAC(C/T)ACGGG intron-variant
rs1032441 -- 129,378,166(+) GCTCC(A/G)TTATT intron-variant
rs10596885 -- 129,426,801(+) GTGGA(-/T)TTTTT intron-variant
rs10694005 -- 129,439,913(+) GAGAA(-/TT/TTT)TTTTT intron-variant
rs10736575 -- 129,443,943(+) CCAAA(C/T)GTTAG intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for BARX2 Gene

Variant ID Type Subtype PubMed ID
nsv952761 CNV deletion 24416366
nsv546 CNV insertion 18451855
nsv475507 CNV novel sequence insertion 20440878
nsv1046731 CNV gain 25217958
nsv1036787 CNV gain 25217958
esv3579967 CNV loss 25503493

Variation tolerance for BARX2 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BARX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BARX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BARX2 Gene

Disorders for BARX2 Gene

Relevant External Links for BARX2

Genetic Association Database (GAD)
BARX2
Human Genome Epidemiology (HuGE) Navigator
BARX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BARX2

No disorders were found for BARX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BARX2 Gene

Publications for BARX2 Gene

  1. The human BARX2 gene: genomic structure, chromosomal localization, and single nucleotide polymorphisms. (PMID: 10644443) Hjalt T.A. … Murray J.C. (Genomics 1999) 2 3 4 64
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
  3. Cloning and chromosomal localization of the human BARX2 homeobox protein gene. (PMID: 10854790) Krasner A. … Nelkin B.D. (Gene 2000) 3 4 64
  4. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey M.L. … Hieter P. (Genetics 2015) 3 64
  5. A genome-wide association search for type 2 diabetes genes in African Americans. (PMID: 22238593) Palmer N.D. … Sladek R. (PLoS ONE 2012) 3 64

Products for BARX2 Gene

Sources for BARX2 Gene

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