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BARX1 Gene

protein-coding   GIFtS: 55
GCID: GC09M096713

BARX Homeobox 1

(Previous name: BarH-like homeobox 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BARX Homeobox 11 2
BarH-Like Homeobox 11 2
Homeobox Protein BarH-Like 12

External Ids:    HGNC: 9551   Entrez Gene: 560332   Ensembl: ENSG000001316687   OMIM: 6032605   UniProtKB: Q9HBU13   

Export aliases for BARX1 gene to outside databases

Previous GC identifers: GC09M087540 GC09M088441 GC09M090013 GC09M092055 GC09M093793 GC09M095753 GC09M066390


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BARX1 Gene:
This gene encodes a member of the Bar subclass of homeobox transcription factors. Studies of the mouse and chick
homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural
crest origin. The protein may also be associated with differentiation of stomach epithelia. (provided by RefSeq,
Jul 2008)

GeneCards Summary for BARX1 Gene:
BARX1 (BARX homeobox 1) is a protein-coding gene. Diseases associated with BARX1 include iridogoniodysgenesis syndrome, and hard palate cancer. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DLX2.

UniProtKB/Swiss-Prot: BARX1_HUMAN, Q9HBU1
Function: Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach
organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing
endodermal Wnt activity (By similarity). Binds to a regulatory module of the NCAM promoter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the BARX1 gene promoter:
         Max1   RP58   NF-1/L   NF-1   STAT5A   IRF-1   Nkx2-5   AP-2gamma   AREB6   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for BARX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BARX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q12   Ensembl cytogenetic band:  9q22.32   HGNC cytogenetic band: 9q22.32

BARX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BARX1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M096713:  view genomic region     (about GC identifiers)

Start:
96,713,905 bp from pter      End:
96,717,654 bp from pter
Size:
3,750 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BARX1_HUMAN, Q9HBU1 (See protein sequence)
Recommended Name: Homeobox protein BarH-like 1  
Size: 254 amino acids; 27298 Da
Sequence caution: Sequence=AAG23738.1; Type=Frameshift; Positions=Several;
1 PDB 3D structure from and Proteopedia for BARX1:
2DMT (3D)    
Secondary accessions: Q6P2R4 Q96GH8
Alternative splicing: 2 isoforms:  Q9HBU1-1   Q9HBU1-2   

Explore the universe of human proteins at neXtProt for BARX1: NX_Q9HBU1

Explore proteomics data for BARX1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BARX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067545.3  
    ENSEMBL proteins: 
     ENSP00000253968   ENSP00000385613  

    BARX1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for BARX1
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    Novus Biologicals BARX1 Protein
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    Cloud-Clone Corp. Proteins for BARX1

    BARX1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for BARX1

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    Cloud-Clone Corp. ELISAs for BARX1
    Cloud-Clone Corp. CLIAs for BARX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NKL: Homeoboxes / ANTP class : NKL subclass

    5 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9HBU1

    ProtoNet protein and cluster: Q9HBU1

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: BARX1_HUMAN, Q9HBU1
    Similarity: Belongs to the BAR homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    BARX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BARX1_HUMAN, Q9HBU1
    Function: Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach
    organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing
    endodermal Wnt activity (By similarity). Binds to a regulatory module of the NCAM promoter

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10995576
    GO:0043565sequence-specific DNA binding ----
         
    BARX1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BARX1:
     Decreased homologous recombina 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Barx1):
     cellular  craniofacial  digestive/alimentary  mortality/aging 

    BARX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Barx1tm1Shiv for BARX1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BARX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BARX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BARX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BARX1

    miRNA
    Products:
        
    miRTarBase miRNAs that target BARX1:
    hsa-mir-124-3p (MIRT022812)

    Block miRNA regulation of human, mouse, rat BARX1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate BARX1:
    hsa-miR-3163 hsa-miR-550a hsa-miR-597 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidBARX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BARX1
    Predesigned siRNA for gene silencing in human, mouse, rat BARX1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: BARX1 (NM_021570)
    Sino Biological Human cDNA Clone for BARX1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BARX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BARX1

    Cell Line
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    ESI BIO PureStem Progenitors for BARX1: 
    PureStem 4D20.8, NCr-fac Progenitor, PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BARX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BARX1_HUMAN, Q9HBU1: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228nuclear chromosome ----
    GO:0005634nucleus IEA--

    BARX1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including BARX1: 
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for BARX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for BARX1 (Q9HBU12, 3 ENSP000002539684) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8260757 I2D: score=2 
    RPS6KA3P518122, 3, ENSP000003688844MINT-8269516 I2D: score=2 STRING: ENSP00000368884
    ZNF641Q96N773, ENSP000003010424I2D: score=1 STRING: ENSP00000301042
    SFRP1Q8N4743, ENSP000002207724I2D: score=1 STRING: ENSP00000220772
    SFRP2Q96HF13, ENSP000002740634I2D: score=1 STRING: ENSP00000274063
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007267cell-cell signaling IEA--
    GO:0007275multicellular organismal development ----
    GO:0009888tissue development ----

    BARX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BARX1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BARX1 gene: 
    NM_021570.3  

    Unigene Cluster for BARX1:

    BARX homeobox 1
    Hs.164960  [show with all ESTs]
    Unigene Representative Sequence: BM563421
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253968(uc010mrh.3) ENST00000401724(uc004aud.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BARX1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate BARX1:
    hsa-miR-3163 hsa-miR-550a hsa-miR-597 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidBARX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BARX1
    Predesigned siRNA for gene silencing in human, mouse, rat BARX1
    Clone
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    OriGene clones in human, mouse for BARX1 (see all 7)
    OriGene ORF clones in mouse, rat for BARX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BARX1 (NM_021570)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BARX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BARX1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BARX1
    OriGene qSTAR qPCR primer pairs in human, mouse for BARX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BARX1
      QuantiTect SYBR Green Assays in human, mouse, rat BARX1
      QuantiFast Probe-based Assays in human, mouse, rat BARX1

    Additional mRNA sequence: 

    AF213356.1 BC009458.1 BC064363.1 

    2 DOTS entries:

    DT.100016619  DT.303297 

    Selected AceView cDNA sequences (see all 34):

    AI623151 BE464546 AW514391 CR592249 BC064363 AI445581 BE883480 BM738686 
    BM453164 AI459280 BX094328 BG829554 BF981618 AW130310 AI440279 BC009458 
    AI292221 BU624499 AL577926 AA442582 AA506079 BE266464 NM_021570 BG896578 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BARX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGAGGCC
    BARX1 Expression
    About this image


    BARX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 4 entries
             Cranial Neural Crest Cells Branchial Arch 2
             PureStem 4D20.8, NCr-fac Progenitor
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 4 entries
             Cranial Neural Crest Cells Branchial Arch 2
             Branchial Arch 1
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Maxillary Process
             TGFbeta3+BMP7-induced chondrocytes
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Tooth
             Odontoblasts Dentin
    BARX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BARX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.164960

    UniProtKB/Swiss-Prot: BARX1_HUMAN, Q9HBU1
    Tissue specificity: Widely expressed. Expressed at higher levels in testis and heart. Detected in craniofacial
    tissue and adult iris, but not in lymphocytes, fibroblasts, choroid retina, retinal pigment epithelium, kidney,
    or fetal liver

        Pathway & Disease-focused RT2 Profiler PCR Array including BARX1: 
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BARX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BARX1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Barx11 , 5 BarH-like homeobox 11, 5 88.06(n)1
    95.67(a)1
      13 (24.90 cM)5
    120221  NM_007526.41  NP_031552.21 
     486629985 
    chicken
    (Gallus gallus)
    Aves BARX11 BARX homeobox 1 80.43(n)
    82.19(a)
      374017  NM_204193.1  NP_989524.1 
    lizard
    (Anolis carolinensis)
    Reptilia BARX16
    BARX homeobox 1
    73(a)
    1 ↔ 1
    GL343225.1(878069-897333)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004917511 homeobox protein BarH-like 1b-like 69.1(n)
    76.52(a)
      100491751  XM_004914825.1  XP_004914882.1 
    zebrafish
    (Danio rerio)
    Actinopterygii barx11 BarH-like homeobox 1 65.8(n)
    72.73(a)
      553644  NM_001024949.1  NP_001020120.1 


    ENSEMBL Gene Tree for BARX1 (if available)
    TreeFam Gene Tree for BARX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BARX1 gene
    DLX22  GBX12  NKX1-12  VENTX2  GBX22  BARHL12  BARHL22  MNX12  
    BARX22  DLX12  DLX32  LBX22  NKX1-22  BSX2  DLX52  DLX62  
    DLX42  LBX12  MSX22  MSX12  
    8 SIMAP similar genes for BARX1 using alignment to 1 protein entry:     BARX1_HUMAN:
    HOXA4    BARX2    HMX2    DLX6    HLX    DLX1
    HOXB1    DLX3

    BARX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    BARX1_HUMAN, Q9HBU1: The polymorphism is not associated with Axenfeld-Reiger syndrome (ARS), iridogoniodysgenesis
    syndrome (IGDS) or related ocular malformations


    Selected SNPs for BARX1 (see all 91)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs117933241,2
    C,F,H--96713690(+) GGCCCC/TTCACG 1 -- ds500120Minor allele frequency- T:0.18NS EA NA CSA WA 2330
    rs574835691,2
    C,F--96713749(+) CCGTGC/TCTAGC 1 -- ds50013Minor allele frequency- T:0.05WA CSA 122
    rs1168600241,2
    C,F--96714028(+) GCAATC/TTCAGG 1 -- ut311Minor allele frequency- T:0.07NA 120
    rs10577151,2
    C,F--96714119(-) TCTGGG/AGCCTG 1 -- ut316Minor allele frequency- A:0.13MN NA WA EA 546
    rs10577131,2
    C,F,A,H--96714161(-) ACGCGT/CATTCA 1 -- ut31 ese323Minor allele frequency- C:0.33MN NS EA NA WA CSA 2534
    rs1825997081,2
    --96714162(+) GAATAA/CGCGTG 1 -- ut310--------
    rs1880096891,2
    --96714251(+) CAGAAA/GCGCGC 1 -- ut310--------
    rs593971231,2
    C--96714338(+) AAAGGC/TTTAGG 1 -- ut315Minor allele frequency- T:0.09WA CSA NA EA 361
    rs22978351,2
    C,F--96714429(+) GGCCCC/AGCACC 1 -- ut31 ese35Minor allele frequency- A:0.07EA NA CSA EU 2099
    rs1995273591,2
    C--96714454(+) GTCCTC/TGCGGC 2 K E mis10--------

    HapMap Linkage Disequilibrium report for BARX1 (96713905 - 96717654 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BARX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509312CNV Insertion20534489
    nsv893590CNV Loss21882294
    nsv893589CNV Gain21882294
    nsv824993CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BARX1
    DNA2.0 Custom Variant and Variant Library Synthesis for BARX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603260    OMIM disorders: --

    5 diseases for BARX1:    
    About MalaCards
    iridogoniodysgenesis syndrome    hard palate cancer    cleft lip    choroiditis
    retinitis

    1 disease from the University of Copenhagen DISEASES database for BARX1:
    Hard palate cancer

    BARX1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BARX1
    Human Genome Epidemiology (HuGE) Navigator: BARX1 (2 documents)

    Export disorders for BARX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BARX1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with BARX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, characterization, localization, and mutational screening of the human BARX1 gene. (PubMed id 10995576)1, 2, 9 Gould D.B. and Walter M.A. (Genomics 2000)
    2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    5. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Barx1, growth factors and apoptosis in facial tissue of children with clefts. (PubMed id 18708738)1 Krivicka-Uzkurele B....Akota I. (quot 2008)
    8. Absence of PITX2, BARX1, and FOXC1 mutations in De Hauwere syndrome (Axenfeld-Rieger anomaly, hydrocephaly, hearing loss): a 25-year follow up. (PubMed id 17486624)1 Lowry R.B....Savage P.R. (Am. J. Med. Genet. A 2007)
    9. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56033 HGNC: 955 AceView: BARX1 Ensembl:ENSG00000131668 euGenes: HUgn56033
    ECgene: BARX1 H-InvDB: BARX1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BARX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BARX1 gene:
    Search GeneIP for patents involving BARX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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