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Aliases for BARHL2 Gene

Aliases for BARHL2 Gene

  • BarH-Like Homeobox 2 2 3
  • BarH (Drosophila)-Like 2 2

External Ids for BARHL2 Gene

Summaries for BARHL2 Gene

GeneCards Summary for BARHL2 Gene

BARHL2 (BarH-Like Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is DLX5.

UniProtKB/Swiss-Prot for BARHL2 Gene

  • Potential regulator of neural basic helix-loop-helix genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BARHL2 Gene

Genomics for BARHL2 Gene

Genomic Location for BARHL2 Gene

Start:
90,711,539 bp from pter
End:
90,717,237 bp from pter
Size:
5,699 bases
Orientation:
Minus strand

Genomic View for BARHL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BARHL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BARHL2 Gene

Regulatory Elements for BARHL2 Gene

Proteins for BARHL2 Gene

  • Protein details for BARHL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY43-BARH2_HUMAN
    Recommended name:
    BarH-like 2 homeobox protein
    Protein Accession:
    Q9NY43
    Secondary Accessions:
    • A0AVP2
    • Q7Z4N7

    Protein attributes for BARHL2 Gene

    Size:
    387 amino acids
    Molecular mass:
    41981 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BARHL2 Gene

Proteomics data for BARHL2 Gene at MOPED

Post-translational modifications for BARHL2 Gene

No Post-translational modifications

Other Protein References for BARHL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BARHL2 Gene

Domains for BARHL2 Gene

Gene Families for BARHL2 Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

Suggested Antigen Peptide Sequences for BARHL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NY43

UniProtKB/Swiss-Prot:

BARH2_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • Q9NY43
Family:
  • Belongs to the BAR homeobox family.:
    • Q9NY43
genes like me logo Genes that share domains with BARHL2: view

Function for BARHL2 Gene

Molecular function for BARHL2 Gene

UniProtKB/Swiss-Prot Function: Potential regulator of neural basic helix-loop-helix genes.

Gene Ontology (GO) - Molecular Function for BARHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with BARHL2: view
genes like me logo Genes that share phenotypes with BARHL2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BARHL2 Gene

Localization for BARHL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BARHL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BARHL2 Gene COMPARTMENTS Subcellular localization image for BARHL2 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for BARHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with BARHL2: view

Pathways for BARHL2 Gene

SuperPathways for BARHL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BARHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001709 cell fate determination IEA --
GO:0001764 neuron migration IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0007399 nervous system development --
genes like me logo Genes that share ontologies with BARHL2: view

No data available for Pathways by source for BARHL2 Gene

Transcripts for BARHL2 Gene

mRNA/cDNA for BARHL2 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BARHL2 Gene

No ASD Table

Relevant External Links for BARHL2 Gene

GeneLoc Exon Structure for
BARHL2
ECgene alternative splicing isoforms for
BARHL2

Expression for BARHL2 Gene

mRNA expression in normal human tissues for BARHL2 Gene

mRNA differential expression in normal tissues according to GTEx for BARHL2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (25.1) and Brain - Cerebellum (24.3).

SOURCE GeneReport for Unigene cluster for BARHL2 Gene Hs.451956

genes like me logo Genes that share expressions with BARHL2: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for BARHL2 Gene

Orthologs for BARHL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BARHL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BARHL2 35
  • 97.42 (n)
  • 96.12 (a)
BARHL2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BARHL2 35
  • 90.44 (n)
  • 94.21 (a)
BARHL2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BARHL2 35
  • 92.69 (n)
  • 97.69 (a)
BARHL2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Barhl2 35
  • 88.98 (n)
  • 93.18 (a)
Barhl2 16
Barhl2 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BARHL2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BARHL2 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Barhl2 35
  • 89.41 (n)
  • 93.18 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC398182 35
tropical clawed frog
(Silurana tropicalis)
Amphibia barhl2 35
  • 75.05 (n)
  • 84 (a)
zebrafish
(Danio rerio)
Actinopterygii barhl2 35
  • 71.99 (n)
  • 81.82 (a)
barhl2 36
  • 84 (a)
OneToOne
Dr.16934 35
fruit fly
(Drosophila melanogaster)
Insecta CG11085 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-30 36
  • 35 (a)
ManyToMany
ceh-31 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for BARHL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BARHL2 Gene

ENSEMBL:
Gene Tree for BARHL2 (if available)
TreeFam:
Gene Tree for BARHL2 (if available)

Paralogs for BARHL2 Gene

Selected SIMAP similar genes for BARHL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BARHL2: view

Variants for BARHL2 Gene

Sequence variations from dbSNP and Humsavar for BARHL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs915396 -- 90,711,905(+) CTGCC(A/T)GTGCT downstream-variant-500B
rs915397 -- 90,713,450(+) AGGAA(C/T)GCAGG intron-variant
rs1335726 -- 90,714,733(+) AATCT(A/C)CCGGT reference, stop-gained
rs1342785 -- 90,713,093(+) AAACC(A/G)TAAAC intron-variant
rs2390606 -- 90,712,090(+) GGGAG(A/C)TTTCC utr-variant-3-prime

Relevant External Links for BARHL2 Gene

HapMap Linkage Disequilibrium report
BARHL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BARHL2 Gene

Disorders for BARHL2 Gene

Relevant External Links for BARHL2

Genetic Association Database (GAD)
BARHL2
genes like me logo Genes that share disorders with BARHL2: view

No data available for UniProtKB/Swiss-Prot for BARHL2 Gene

Publications for BARHL2 Gene

  1. Role of the Barhl2 homeobox gene in the specification of glycinergic amacrine cells. (PMID: 14998930) Mo Z. … Xiang M. (Development 2004) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS. (PMID: 10814725) Bulfone A. … Banfi S. (Hum. Mol. Genet. 2000) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for BARHL2 Gene

Sources for BARHL2 Gene

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