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Aliases for BARHL2 Gene

Aliases for BARHL2 Gene

  • BarH Like Homeobox 2 2 3
  • BarH-Like Homeobox 2 2 5
  • BarH (Drosophila)-Like 2 2

External Ids for BARHL2 Gene

Previous GeneCards Identifiers for BARHL2 Gene

  • GC01U990337
  • GC01M090353
  • GC01M090514
  • GC01M090889
  • GC01M091177
  • GC01M089296

Summaries for BARHL2 Gene

GeneCards Summary for BARHL2 Gene

BARHL2 (BarH Like Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is BARX2.

UniProtKB/Swiss-Prot for BARHL2 Gene

  • Potential regulator of neural basic helix-loop-helix genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BARHL2 Gene

Genomics for BARHL2 Gene

Regulatory Elements for BARHL2 Gene

Genomic Location for BARHL2 Gene

Chromosome:
1
Start:
90,711,539 bp from pter
End:
90,717,237 bp from pter
Size:
5,699 bases
Orientation:
Minus strand

Genomic View for BARHL2 Gene

Genes around BARHL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BARHL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BARHL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BARHL2 Gene

Proteins for BARHL2 Gene

  • Protein details for BARHL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY43-BARH2_HUMAN
    Recommended name:
    BarH-like 2 homeobox protein
    Protein Accession:
    Q9NY43
    Secondary Accessions:
    • A0AVP2
    • Q7Z4N7

    Protein attributes for BARHL2 Gene

    Size:
    387 amino acids
    Molecular mass:
    41981 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BARHL2 Gene

Proteomics data for BARHL2 Gene at MOPED

Post-translational modifications for BARHL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BARHL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BARHL2 Gene

Domains & Families for BARHL2 Gene

Gene Families for BARHL2 Gene

Suggested Antigen Peptide Sequences for BARHL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NY43

UniProtKB/Swiss-Prot:

BARH2_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the BAR homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the BAR homeobox family.
genes like me logo Genes that share domains with BARHL2: view

Function for BARHL2 Gene

Molecular function for BARHL2 Gene

UniProtKB/Swiss-Prot Function:
Potential regulator of neural basic helix-loop-helix genes.

Gene Ontology (GO) - Molecular Function for BARHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BARHL2: view
genes like me logo Genes that share phenotypes with BARHL2: view

Animal Models for BARHL2 Gene

MGI Knock Outs for BARHL2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BARHL2 Gene

Localization for BARHL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BARHL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BARHL2 Gene COMPARTMENTS Subcellular localization image for BARHL2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for BARHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with BARHL2: view

Pathways & Interactions for BARHL2 Gene

SuperPathways for BARHL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BARHL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030182 neuron differentiation IEA --
GO:0030516 regulation of axon extension IEA --
GO:0045165 cell fate commitment IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with BARHL2: view

No data available for Pathways by source and SIGNOR curated interactions for BARHL2 Gene

Drugs & Compounds for BARHL2 Gene

No Compound Related Data Available

Transcripts for BARHL2 Gene

mRNA/cDNA for BARHL2 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BARHL2 Gene

No ASD Table

Relevant External Links for BARHL2 Gene

GeneLoc Exon Structure for
BARHL2
ECgene alternative splicing isoforms for
BARHL2

Expression for BARHL2 Gene

mRNA expression in normal human tissues for BARHL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BARHL2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x25.1) and Brain - Cerebellum (x24.3).

SOURCE GeneReport for Unigene cluster for BARHL2 Gene Hs.451956

genes like me logo Genes that share expression patterns with BARHL2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BARHL2 Gene

Orthologs for BARHL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BARHL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BARHL2 35
  • 90.44 (n)
  • 94.21 (a)
BARHL2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BARHL2 35
  • 92.69 (n)
  • 97.69 (a)
BARHL2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Barhl2 35
  • 88.98 (n)
  • 93.18 (a)
Barhl2 16
Barhl2 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BARHL2 35
  • 97.42 (n)
  • 96.12 (a)
BARHL2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Barhl2 35
  • 89.41 (n)
  • 93.18 (a)
oppossum
(Monodelphis domestica)
Mammalia BARHL2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BARHL2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia barhl2 35
  • 75.05 (n)
  • 84 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398182 35
zebrafish
(Danio rerio)
Actinopterygii barhl2 35
  • 71.99 (n)
  • 81.82 (a)
Dr.16934 35
barhl2 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11085 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-30 36
  • 35 (a)
ManyToMany
ceh-31 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for BARHL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BARHL2 Gene

ENSEMBL:
Gene Tree for BARHL2 (if available)
TreeFam:
Gene Tree for BARHL2 (if available)

Paralogs for BARHL2 Gene

Paralogs for BARHL2 Gene

(2) SIMAP similar genes for BARHL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BARHL2: view

Variants for BARHL2 Gene

Sequence variations from dbSNP and Humsavar for BARHL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs915396 -- 90,711,905(+) CTGCC(A/T)GTGCT downstream-variant-500B
rs915397 -- 90,713,450(+) AGGAA(C/T)GCAGG intron-variant
rs1342785 -- 90,713,093(+) AAACC(A/G)TAAAC intron-variant
rs1335726 -- 90,714,733(+) AATCT(A/C)CCGGT reference, stop-gained
rs2390606 -- 90,712,090(+) GGGAG(A/C)TTTCC utr-variant-3-prime

Variation tolerance for BARHL2 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BARHL2 Gene

HapMap Linkage Disequilibrium report
BARHL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BARHL2 Gene

Disorders for BARHL2 Gene

Relevant External Links for BARHL2

Genetic Association Database (GAD)
BARHL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BARHL2

No disorders were found for BARHL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BARHL2 Gene

Publications for BARHL2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Role of the Barhl2 homeobox gene in the specification of glycinergic amacrine cells. (PMID: 14998930) Mo Z. … Xiang M. (Development 2004) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS. (PMID: 10814725) Bulfone A. … Banfi S. (Hum. Mol. Genet. 2000) 3

Products for BARHL2 Gene

Sources for BARHL2 Gene

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