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BANP Gene

protein-coding   GIFtS: 53

GC16P086542
BTG3 associated nuclear protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
BEND1 1, 2, 3
DKFZp761H172 1, 2
FLJ10177 1, 2
FLJ20538 1, 2
SMAR1 1, 2, 3, 5
SMARBP1 1, 2
Descriptions
BEN domain containing 1 2
BEN domain-containing protein 1 3
BTG3 associated nuclear protein 2
Btg3-associated nuclear protein 3
Scaffold/matrix-associated region-1-binding protein 2, 3
External Ids
HGNC: 134501
Entrez Gene: 549712
UniProtKB: Q8N9N53
Ensembl: ENSG000001725307
Search outside databases for aliases for BANP gene

Previous GC identifers: GC18M011860 GC16P089015 GC16P087725 GC16P087766

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BANP:
This gene encodes a protein that binds to matrix attachment regions. The protein functions as a
tumor suppressor and cell cycle regulator. Alternate transcriptional splice variants, encoding
different isoforms, have been characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: BANP_HUMAN, Q8N9N5
Function: Controls V(D)J recombination during T-cell development by repressing T-cell receptor
(TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an
ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription
by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels.
Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest
(By similarity)

Gene Wiki entry for BANP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BANP gene  

Entrez Gene cytogenetic band: 16q24.2-q24.3   Ensembl cytogenetic band:  16q24.2   HGNC cytogenetic band: 16q24

BANP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P086542:     (about GC identifiers)

Start:
86,542,539 bp from pter
End:
86,668,425 bp from pter
Size:
125,887 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000016.8  NT_010498.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BANP_HUMAN, Q8N9N5 (See protein sequence)
Recommended Name: Protein BANP  
Size: 519 amino acids; 56484 Da
Subunit: Interacts with TP53 and CUX1/CDP (By similarity). Interacts with HDAC1. Part of a
corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2
Subcellular location: Nucleus
Secondary accessions: A8MU25 Q96GJ7 Q9NWY1
Alternative splicing: 3 isoforms:  Q8N9N5-1   Q8N9N5-2   Q8N9N5-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_060339.2  NP_524576.2  


    ENSEMBL proteins: 
    ENSP00000286122 ENSP00000347290 ENSP00000347125 ENSP00000376903 ENSP00000376902 ENSP00000313421 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (BANP)
    Human Recombinant Proteins from Abnova (BANP)
                  OriGene Purified Recombinant Human Protein: BANP 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for BANP: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for BANP
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (BANP), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (BANP)
    Novus Biologicals Antibodies for BANP

    Assays for BANP: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR018379 BEN_domain


       GeneDecks  BANP for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8N9N5

    ProtoNet protein and cluster: Q8N9N5

    UniProtKB/Swiss-Prot: BANP_HUMAN, Q8N9N5
    Similarity: Belongs to the BANP/SMAR1 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BANP)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_079837

                  Applied Biosystems Silencer® siRNAs for BANP

                  Sigma-Aldrich siRNA for BANP  
                         Sigma-Aldrich shRNA for BANP  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for BANP
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_017869
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_017869
                                     untagged cDNA clones in CMV expression vector (see all 5): NM_017869 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_079837

    UniProtKB/Swiss-Prot: BANP_HUMAN, Q8N9N5
    Function: Controls V(D)J recombination during T-cell development by repressing T-cell receptor
    (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an
    ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription
    by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels.
    Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest
    (By similarity)

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  BANP 


    5/10 Interacting proteins for BANP (ENSP000002861223) via UniProtKB, MINT, and/or STRING (see all 10 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53ENSP000002693053STRING (score=.981)
    CCND1ENSP000002275073STRING (score=.948)
    BTG3ENSP000003446093STRING (score=.938)
    KRT8ENSP000002933083STRING (score=.904)
    NFKBIAENSP000002167973STRING (score=.877)
    About this table

    5 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0007275 multicellular organismal development IEA--
    GO:0016568 chromatin modification IEA--
    GO:0045786 negative regulation of cell cycle IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for BANP

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BANP)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_079837

                  Sigma-Aldrich siRNA for BANP  
                         Sigma-Aldrich shRNA for BANP  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_017869  NM_079837  

    REFSEQ mRNAs for BANP gene (2 alternative transcripts): 

    NM_017869.3   NM_079837.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_017869  NM_079837  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_017869
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_017869
                                     untagged cDNA clones in CMV expression vector (see all 5): NM_017869 

    Additional cDNA sequence: 

    AK001039.1 AK094158.1 AK125232.1 AK293472.1 AK297945.1 AK315089.1 AK315535.1 BC009424.1 
    BC018247.1 

    24 DOTS entries:

    DT.92425420  DT.100706645  DT.95378441  DT.95098443  DT.451949  DT.120686119  DT.100832434  DT.91817711 
    DT.95275274  DT.95295952  DT.120686201  DT.120686143  DT.95227137  DT.95275276  DT.100688898  DT.120686137 
    DT.100740200  DT.100761656  DT.100780216  DT.100780217  DT.100832432  DT.102829785  DT.120686187  DT.95153065 

    24/125 AceView cDNA sequences (see all 125 ):

    NM_017869 CD673246 BX360845 BQ949742 AA902510 NM_079837 BE018428 BM839530 
    BX950991 AK001039 BQ940184 AA368530 AA354067 AW131241 CB961560 BQ650407 
    AK094158 AL549704 AI680137 BQ650135 BQ653123 BX341113 BQ677433 BQ067439 

    highest scoring ESTs for BANP:

    AI738764 AA063445 AI200727 AI362905 AI367317 AI799324 AI992221 AK125232 AL530460 AW137183 

    Unigene Cluster for BANP:

    BTG3 associated nuclear protein
    Hs.461705  [show with all ESTs]
    Unigene Representative Sequence: AK125232


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for BANP (see all 11 )

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
    SP1:              -     -     -     -     -     -                       -     -     -     -     -     -     -     -     -                                       
    SP2:                                                                                            -                                                               
    SP3:                                      -     -           -                                                                                                   
    SP4:                                -     -     -           -                                   -     -     -                                                   
    SP5:                                                        -                                                                                                   

    ExUns: 17 ^ 18
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            

    About this scheme

    ECgene alternative splicing isoforms for BANP

    6 Ensembl transcripts including schematic representations:
    ENST00000286122  ENST00000355163  ENST00000355022  ENST00000393208  ENST00000393207  ENST00000318224  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    BANP expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for BANP

    1 / 2 / 3

    8 probe-sets matching BANP gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    73242_at2, 3 U95-E 1 1.00 1.00 0.98 0.77 AI373509 0.80 0.88 0.84 1

    50761_at2, 3 U95-B 1 1.00 1.00 0.85 1.24 AI738764 1.00 0.90 0.95 1

    233186_s_at2, 3 U133-B 1 1.00 1.00 -- -- AK001039 0.60 1.00 0.82 1

    219966_x_at2, 3 U133-A 1 1.00 1.00 -- -- NM_017869 0.60 1.00 0.82 1

    228928_x_at2, 3 U133-B 1 1.00 1.00 -- -- AL157429 0.60 1.00 0.82 1

    233186_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    219966_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    228928_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  BANP for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AGGCAGGTGT

    SOURCE GeneReport for Unigene cluster: Hs.461705

    UniProtKB/Swiss-Prot: BANP_HUMAN, Q8N9N5
    Tissue specificity: Down-regulated in breast cancer cell lines

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for BANP gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    BANP1   -- BTG3 associated nuclear protein 86.64(n)
    95.26(a)
    479618  XM_536755.2  XP_536755.2 
    chimpanzee
    (Pan troglodytes)
    BANP1   -- BTG3 associated nuclear protein 98.74(n)
    99.49(a)
    454354  XM_511203.2  XP_511203.2 
    cow
    (Bos taurus)
    BANP1   -- BTG3 associated nuclear protein 87.36(n)
    95.69(a)
    513446  NM_001075620.1  NP_001069088.1 
    rat
    (Rattus norvegicus)
    Banp1   -- Btg3 associated nuclear protein 86.18(n)
    96.11(a)
    292064  XM_214701.4  XP_214701.4 
    mouse
    (Mus musculus)
    Banp1, 5 8 (66.00 cM)5
    BTG3 associated nuclear protein1, 5 87.22(n)1
    96.15(a)1
    533251  NM_016812.21  NP_058092.21 
     AA4081585  AA5616215  (see all 30)
    About this table        Species with no ortholog for BANP

    ENSEMBL Gene Tree for BANP
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for BANP gene
    ENSG000001585272  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1173 NCBI SNPs in BANP are shown (see all 1173 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 140)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs75008631,2
    A,C,F,H86668552(+) GGCACG/CCCGGG 2 -- ng314Minor allele frequency- C:0.46EU EA WA 416
    rs74999591,2
    A,C,F,H86667923(+) CCTATC/GAACTG 2 -- ut313Minor allele frequency- G:0.29EU EA 300
    --
    rs72007291,2
    C,F,H86540556(+) CTGTGT/GCAGCT 2 -- ng513Minor allele frequency- G:0.15EU EA 300
    --
    rs65401191,2
    A,C86541978(+) ATGTCA/TGGGAA 2 -- ng510--------
    rs43123091,2
    A,C86542098(-) GCACCA/GAGGGT 2 -- ng510--------
    --
    rs71994541,2
    A86541130(+) caggcA/Gcctgc 2 -- ng510--------
    --
    rs111173591,2
    C86668809(+) CCTGGA/CCTGCT 2 -- ng310--------
    --
    rs72008531,2
    A86541211(+) gatctC/Gctgac 2 -- ng510--------
    --
    rs74998141,2
    A,C,F,H86609662(+) GCGCTA/CACGCT 2 L/L syn1 ese33Minor allele frequency- C:0.36EU EA 300
    rs80502091,2
    A,C,F86663226(+) GCGGCA/GGCGGG 2 A/A syn1 ese31Minor allele frequency- G:0.37NA 46
    About this table

    HapMap Linkage Disequilibrium images for BANP (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 611564

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/17 PubMed articles for BANP gene (see all 17 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 54971 HGNC: 13450 AceView: BANP Ensembl:ENSG00000172530 euGenes: HUgn54971
    ECgene: BANP H-InvDB: BANP
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for BANP:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for BANP-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for BANP Antibodies for BANP
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for BANP Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Recombinant Proteins
    (BANP)
     Antibodies (BANP)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for BANP




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for BANP

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