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Aliases for BANP Gene

Aliases for BANP Gene

  • BTG3 Associated Nuclear Protein 2 3
  • SMAR1 3 4 6
  • Scaffold/Matrix-Associated Region-1-Binding Protein 3 4
  • BEN Domain-Containing Protein 1 3 4
  • BEND1 3 4
  • Btg3-Associated Nuclear Protein 4
  • BEN Domain Containing 1 2
  • Protein BANP 3
  • SMARBP1 3

External Ids for BANP Gene

Previous GeneCards Identifiers for BANP Gene

  • GC18M011860
  • GC16P089015
  • GC16P087725
  • GC16P087766
  • GC16P086542
  • GC16P073724

Summaries for BANP Gene

Entrez Gene Summary for BANP Gene

  • This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for BANP Gene

BANP (BTG3 Associated Nuclear Protein) is a Protein Coding gene. GO annotations related to this gene include p53 binding.

UniProtKB/Swiss-Prot for BANP Gene

  • Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 Ser-15 phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).

Gene Wiki entry for BANP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BANP Gene

Genomics for BANP Gene

Regulatory Elements for BANP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BANP Gene

Start:
87,949,244 bp from pter
End:
88,118,422 bp from pter
Size:
169,179 bases
Orientation:
Plus strand

Genomic View for BANP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BANP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BANP Gene

Proteins for BANP Gene

  • Protein details for BANP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9N5-BANP_HUMAN
    Recommended name:
    Protein BANP
    Protein Accession:
    Q8N9N5
    Secondary Accessions:
    • A8MU25
    • A8MX25
    • B2RCF7
    • B4DNJ9
    • F5GZM0
    • Q96GJ7
    • Q9NWY1

    Protein attributes for BANP Gene

    Size:
    519 amino acids
    Molecular mass:
    56494 Da
    Quaternary structure:
    • Interacts with TP53 and CUX1/CDP (By similarity). Interacts with HDAC1. Part of a corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2.
    SequenceCaution:
    • Sequence=BAC04296.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for BANP Gene

neXtProt entry for BANP Gene

Proteomics data for BANP Gene at MOPED

Post-translational modifications for BANP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BANP Gene

Domains for BANP Gene

Gene Families for BANP Gene

HGNC:
  • BEND :BEN domain containing

Protein Domains for BANP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N9N5

UniProtKB/Swiss-Prot:

BANP_HUMAN :
  • Q8N9N5
Domain:
  • Contains 1 BEN domain.
Family:
  • Belongs to the BANP/SMAR1 family.
genes like me logo Genes that share domains with BANP: view

Function for BANP Gene

Molecular function for BANP Gene

UniProtKB/Swiss-Prot Function: Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 Ser-15 phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).

Gene Ontology (GO) - Molecular Function for BANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with BANP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BANP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BANP Gene

Localization for BANP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BANP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BANP Gene COMPARTMENTS Subcellular localization image for BANP gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with BANP: view

Pathways for BANP Gene

SuperPathways for BANP Gene

No Data Available

Gene Ontology (GO) - Biological Process for BANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0007275 multicellular organismal development IEA --
GO:0016568 chromatin modification IEA --
genes like me logo Genes that share ontologies with BANP: view

No data available for Pathways by source for BANP Gene

Transcripts for BANP Gene

Unigene Clusters for BANP Gene

BTG3 associated nuclear protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BANP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BANP Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - - - - - - - - - - - -
SP2: -
SP3: - - -
SP4: - - - - - - -
SP5: -
SP6: - - - - - - - -
SP7:
SP8:
SP9:
SP10: -
SP11: -

ExUns: 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for BANP Gene

GeneLoc Exon Structure for
BANP
ECgene alternative splicing isoforms for
BANP

Expression for BANP Gene

mRNA expression in normal human tissues for BANP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BANP Gene

SOURCE GeneReport for Unigene cluster for BANP Gene Hs.461705

mRNA Expression by UniProt/SwissProt for BANP Gene

Q8N9N5-BANP_HUMAN
Tissue specificity: Down-regulated in breast cancer cell lines.
genes like me logo Genes that share expressions with BANP: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BANP Gene

Orthologs for BANP Gene

This gene was present in the common ancestor of chordates.

Orthologs for BANP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BANP 35
  • 99.16 (n)
  • 99.77 (a)
BANP 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BANP 35
  • 87.81 (n)
  • 95.03 (a)
BANP 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BANP 35
  • 87.29 (n)
  • 94.66 (a)
BANP 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Banp 35
  • 88.08 (n)
  • 96.25 (a)
Banp 16
Banp 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BANP 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BANP 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Banp 35
  • 87.15 (n)
  • 96.25 (a)
chicken
(Gallus gallus)
Aves BANP 35
  • 78.42 (n)
  • 87.52 (a)
BANP 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BANP 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16198 35
tropical clawed frog
(Silurana tropicalis)
Amphibia banp 35
  • 71.57 (n)
  • 79.32 (a)
MGC76079 35
zebrafish
(Danio rerio)
Actinopterygii banp 35
  • 70.1 (n)
  • 74.28 (a)
banp 36
  • 68 (a)
OneToOne
Species with no ortholog for BANP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BANP Gene

ENSEMBL:
Gene Tree for BANP (if available)
TreeFam:
Gene Tree for BANP (if available)

Paralogs for BANP Gene

Pseudogenes.org Pseudogenes for BANP Gene

genes like me logo Genes that share paralogs with BANP: view

No data available for Paralogs for BANP Gene

Variants for BANP Gene

Sequence variations from dbSNP and Humsavar for BANP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1574432 -- 87,977,679(+) GTTGA(C/T)GTGTA intron-variant
rs3815817 -- 87,983,761(+) AATAA(C/T)AACAT intron-variant
rs3815818 -- 87,983,913(+) TGGCT(C/G)ATAGC intron-variant
rs3815820 -- 87,984,203(+) CAGGT(C/T)CCCAT reference, synonymous-codon, utr-variant-5-prime
rs3890051 -- 88,044,304(+) GCACA(C/T)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BANP Gene

Variant ID Type Subtype PubMed ID
dgv36n68 CNV Loss 17160897
nsv907211 CNV Loss 21882294
dgv920e1 CNV Complex 17122850
nsv907213 CNV Loss 21882294
nsv1919 CNV Loss 18451855
nsv907214 CNV Loss 21882294
esv2714946 CNV Deletion 23290073
esv2714947 CNV Deletion 23290073
nsv907215 CNV Gain 21882294
nsv9472 CNV Loss 18304495
esv23831 CNV Loss 19812545
esv2714948 CNV Deletion 23290073
esv2672889 CNV Deletion 23128226
nsv1920 CNV Loss 18451855
esv2714949 CNV Deletion 23290073
esv2714950 CNV Deletion 23290073
nsv9473 CNV Loss 18304495
esv22847 CNV Loss 19812545
nsv821078 CNV Deletion 20802225
esv2714952 CNV Deletion 23290073
nsv103533 CNV Loss 16902084
nsv512450 CNV Loss 21212237
esv2714953 CNV Deletion 23290073
esv997568 CNV Deletion 20482838
esv1227822 CNV Deletion 17803354
nsv510431 CNV Loss 20534489
esv2714954 CNV Deletion 23290073
dgv2963n71 CNV Loss 21882294
esv2714955 CNV Deletion 23290073
nsv907218 CNV Loss 21882294
nsv907219 CNV Loss 21882294

Relevant External Links for BANP Gene

HapMap Linkage Disequilibrium report
BANP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BANP Gene

Disorders for BANP Gene

Relevant External Links for BANP

Genetic Association Database (GAD)
BANP
Human Genome Epidemiology (HuGE) Navigator
BANP
genes like me logo Genes that share disorders with BANP: view

No data available for UniProtKB/Swiss-Prot for BANP Gene

Publications for BANP Gene

  1. Identification and molecular analysis of BANP. (PMID: 10940556) Birot A.-M. … Rouault J.-P. (Gene 2000) 2 3 4 23
  2. SMAR1 forms a ternary complex with p53-MDM2 and negatively regulates p53-mediated transcription. (PMID: 19303885) Pavithra L. … Chattopadhyay S. (J. Mol. Biol. 2009) 3 23
  3. SMAR1, a novel, alternatively spliced gene product, binds the Scaffold/Matrix-associated region at the T cell receptor beta locus. (PMID: 10950932) Chattopadhyay S. … Chen J. (Genomics 2000) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex. (PMID: 16166625) Rampalli S. … Chattopadhyay S. (Mol. Cell. Biol. 2005) 3 4

Products for BANP Gene

Sources for BANP Gene

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