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Aliases for BANP Gene

Aliases for BANP Gene

  • BTG3 Associated Nuclear Protein 2 3 5
  • Scaffold/Matrix-Associated Region-1-Binding Protein 3 4
  • BEN Domain-Containing Protein 1 3 4
  • BEND1 3 4
  • SMAR1 3 4
  • Btg3-Associated Nuclear Protein 4
  • BEN Domain Containing 1 2
  • Protein BANP 3
  • SMARBP1 3

External Ids for BANP Gene

Previous GeneCards Identifiers for BANP Gene

  • GC18M011860
  • GC16P089015
  • GC16P087725
  • GC16P087766
  • GC16P086542
  • GC16P073724

Summaries for BANP Gene

Entrez Gene Summary for BANP Gene

  • This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for BANP Gene

BANP (BTG3 Associated Nuclear Protein) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity and Gene Expression. GO annotations related to this gene include p53 binding.

UniProtKB/Swiss-Prot for BANP Gene

  • Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 Ser-15 phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).

Gene Wiki entry for BANP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BANP Gene

Genomics for BANP Gene

Regulatory Elements for BANP Gene

Enhancers for BANP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F087947 1.6 FANTOM5 ENCODE 34.2 +3.7 3728 10.5 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC BANP CTU2 LOC100289580 LOC400553 ZCCHC14 SLC7A5 PIR49178
GH16F087982 1.3 FANTOM5 Ensembl ENCODE 23.7 +35.9 35870 5.1 CTCF PKNOX1 ZNF48 RAD21 YY1 GATA3 FOXK2 NCOR1 SMC3 MTA2 BANP LOC400553 ZCCHC14 PIR49178
GH16F087841 1.8 FANTOM5 Ensembl ENCODE 14.6 -96.7 -96679 22.9 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 BANP SLC7A5 FBXO31 LOC400553 ZCCHC14 APRT MAP1LC3B CA5A KLHDC4 PIR45032
GH16F087944 1.3 FANTOM5 ENCODE 18.8 -3.2 -3183 2.4 ATF1 PKNOX1 SIN3A ZBTB40 RAD21 GLIS2 ELK1 SCRT2 ZNF207 RCOR1 BANP ZCCHC14 ENSG00000260443
GH16F087893 1.5 FANTOM5 Ensembl ENCODE 14 -53.2 -53172 5.2 HDAC1 PKNOX1 RAD21 EGR1 CREM EGR2 PAF1 ZNF654 ZEB2 REST CA5A BANP PIEZO1 ENSG00000260121 KLHDC4 ENSG00000260603 PIR40099
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BANP on UCSC Golden Path with GeneCards custom track

Genomic Location for BANP Gene

Chromosome:
16
Start:
87,949,172 bp from pter
End:
88,077,318 bp from pter
Size:
128,147 bases
Orientation:
Plus strand

Genomic View for BANP Gene

Genes around BANP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BANP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BANP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BANP Gene

Proteins for BANP Gene

  • Protein details for BANP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9N5-BANP_HUMAN
    Recommended name:
    Protein BANP
    Protein Accession:
    Q8N9N5
    Secondary Accessions:
    • A8MU25
    • A8MX25
    • B2RCF7
    • B4DNJ9
    • F5GZM0
    • Q96GJ7
    • Q9NWY1

    Protein attributes for BANP Gene

    Size:
    519 amino acids
    Molecular mass:
    56494 Da
    Quaternary structure:
    • Interacts with TP53 and CUX1/CDP (By similarity). Interacts with HDAC1. Part of a corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2.
    SequenceCaution:
    • Sequence=BAC04296.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for BANP Gene

neXtProt entry for BANP Gene

Post-translational modifications for BANP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BANP Gene

Domains & Families for BANP Gene

Gene Families for BANP Gene

Protein Domains for BANP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N9N5

UniProtKB/Swiss-Prot:

BANP_HUMAN :
  • Contains 1 BEN domain.
  • Belongs to the BANP/SMAR1 family.
Domain:
  • Contains 1 BEN domain.
Family:
  • Belongs to the BANP/SMAR1 family.
genes like me logo Genes that share domains with BANP: view

Function for BANP Gene

Molecular function for BANP Gene

UniProtKB/Swiss-Prot Function:
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 Ser-15 phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).

Gene Ontology (GO) - Molecular Function for BANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with BANP: view
genes like me logo Genes that share phenotypes with BANP: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BANP Gene

Localization for BANP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BANP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BANP gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with BANP: view

Pathways & Interactions for BANP Gene

genes like me logo Genes that share pathways with BANP: view

Gene Ontology (GO) - Biological Process for BANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0007275 multicellular organism development IEA --
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with BANP: view

No data available for SIGNOR curated interactions for BANP Gene

Transcripts for BANP Gene

Unigene Clusters for BANP Gene

BTG3 associated nuclear protein:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BANP Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - - - - - - - - - - - -
SP2: -
SP3: - - -
SP4: - - - - - - -
SP5: -
SP6: - - - - - - - -
SP7:
SP8:
SP9:
SP10: -
SP11: -

ExUns: 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for BANP Gene

GeneLoc Exon Structure for
BANP
ECgene alternative splicing isoforms for
BANP

Expression for BANP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BANP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BANP Gene

This gene is overexpressed in Retina (15.2), Blymphocyte (15.0), NK cells (12.6), Testis (6.9), CD8 Tcells (6.8), and Ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BANP Gene



Protein tissue co-expression partners for BANP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BANP Gene:

BANP

SOURCE GeneReport for Unigene cluster for BANP Gene:

Hs.461705

mRNA Expression by UniProt/SwissProt for BANP Gene:

Q8N9N5-BANP_HUMAN
Tissue specificity: Down-regulated in breast cancer cell lines.
genes like me logo Genes that share expression patterns with BANP: view

No data available for mRNA differential expression in normal tissues for BANP Gene

Orthologs for BANP Gene

This gene was present in the common ancestor of chordates.

Orthologs for BANP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BANP 34 35
  • 99.16 (n)
mouse
(Mus musculus)
Mammalia Banp 34 16 35
  • 88.08 (n)
cow
(Bos Taurus)
Mammalia BANP 34 35
  • 87.81 (n)
dog
(Canis familiaris)
Mammalia BANP 34 35
  • 87.29 (n)
rat
(Rattus norvegicus)
Mammalia Banp 34
  • 87.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BANP 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BANP 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves BANP 34 35
  • 78.42 (n)
lizard
(Anolis carolinensis)
Reptilia BANP 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia banp 34
  • 71.57 (n)
MGC76079 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16198 34
zebrafish
(Danio rerio)
Actinopterygii banp 34 35
  • 70.1 (n)
Species where no ortholog for BANP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BANP Gene

ENSEMBL:
Gene Tree for BANP (if available)
TreeFam:
Gene Tree for BANP (if available)

Paralogs for BANP Gene

Pseudogenes.org Pseudogenes for BANP Gene

genes like me logo Genes that share paralogs with BANP: view

No data available for Paralogs for BANP Gene

Variants for BANP Gene

Sequence variations from dbSNP and Humsavar for BANP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10438597 -- 88,040,334(+) TCCTC(C/T)GGGCT intron-variant
rs10438598 -- 88,040,575(+) TCACA(C/T)GGCCC intron-variant
rs10534156 -- 88,067,061(+) ACTCG(-/CTCT)CTTTT intron-variant
rs10580939 -- 87,986,567(+) TAGTT(-/TAAGA)TAAGA intron-variant
rs10624509 -- 87,971,016(+) ATCTC(-/AA/AAA)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BANP Gene

Variant ID Type Subtype PubMed ID
nsv978010 CNV duplication 23825009
nsv978008 CNV duplication 23825009
nsv9473 CNV loss 18304495
nsv9472 CNV loss 18304495
nsv821078 CNV deletion 20802225
nsv512450 CNV loss 21212237
nsv510431 OTHER sequence alteration 20534489
nsv1920 CNV deletion 18451855
nsv1919 CNV deletion 18451855
nsv1132444 CNV duplication 24896259
nsv1123082 CNV deletion 24896259
nsv1077833 CNV duplication 25765185
nsv1066924 CNV loss 25217958
nsv1062946 CNV gain 25217958
nsv1059786 CNV gain 25217958
nsv1058708 CNV gain 25217958
nsv1058465 CNV gain 25217958
nsv103533 CNV deletion 16902084
esv997568 CNV deletion 20482838
esv3892935 CNV loss 25118596
esv3364175 CNV duplication 20981092
esv2758668 CNV loss 17122850
esv2714955 CNV deletion 23290073
esv2714954 CNV deletion 23290073
esv2714953 CNV deletion 23290073
esv2714952 CNV deletion 23290073
esv2714950 CNV deletion 23290073
esv2714949 CNV deletion 23290073
esv2714948 CNV deletion 23290073
esv2714947 CNV deletion 23290073
esv2714946 CNV deletion 23290073
esv2672889 CNV deletion 23128226
esv23831 CNV loss 19812545
esv22847 CNV loss 19812545
esv1227822 CNV deletion 17803354
dgv36n68 CNV loss 17160897

Variation tolerance for BANP Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BANP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BANP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BANP Gene

Disorders for BANP Gene

Relevant External Links for BANP

Genetic Association Database (GAD)
BANP
Human Genome Epidemiology (HuGE) Navigator
BANP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BANP

No disorders were found for BANP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BANP Gene

Publications for BANP Gene

  1. Identification and molecular analysis of BANP. (PMID: 10940556) Birot A.-M. … Rouault J.-P. (Gene 2000) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8. (PMID: 20719862) Vitart V. … Wright A. (Hum. Mol. Genet. 2010) 3 46 64
  4. SMAR1 forms a ternary complex with p53-MDM2 and negatively regulates p53-mediated transcription. (PMID: 19303885) Pavithra L. … Chattopadhyay S. (J. Mol. Biol. 2009) 3 22 64
  5. Loci at chromosomes 13, 19 and 20 influence age at natural menopause. (PMID: 19448619) Stolk L. … Uitterlinden A.G. (Nat. Genet. 2009) 3 46 64

Products for BANP Gene

Sources for BANP Gene

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