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Aliases & Descriptions for BANP
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases BEND1 1 , 2 , 3 DKFZp761H172 1 , 2 FLJ10177 1 , 2 FLJ20538 1 , 2 SMAR1 1 , 2 , 3 , 5 SMARBP1 1 , 2
Descriptions BEN domain containing 1 2 BEN domain-containing protein 1 3 BTG3 associated nuclear protein 2 Btg3-associated nuclear protein 3 Scaffold/matrix-associated region-1-binding protein 2 , 3
Search outside databases for aliases for BANP genePrevious GC identifers: GC18M011860 GC16P089015 GC16P087725 GC16P087766
Summaries for BANP (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for BANP : This gene encodes a protein that binds to matrix attachment regions. The protein functions as atumor suppressor and cell cycle regulator. Alternate transcriptional splice variants, encodingdifferent isoforms, have been characterized. [provided by RefSeq] UniProtKB/Swiss-Prot: BANP_HUMAN, Q8N9N5 Function : Controls V(D)J recombination during T-cell development by repressing T-cell receptor(TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), anATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcriptionby recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels.Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest(By similarity)
Gene Wiki entry for BANP
Genomic Location for BANP
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the BANP gene Entrez Gene cytogenetic band: 16q24.2-q24.3 Ensembl cytogenetic band: 16q24.2 HGNC cytogenetic band: 16q24 BANP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16P086542:
(about GC identifiers )
Start:
86,542,539 bp from pter
End:
86,668,425 bp from pter
Size:
125,887 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000016.8 NT_010498.15 Proteins for BANP
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: BANP_HUMAN, Q8N9N5 (See
protein sequence )Recommended Name: Protein BANP Size : 519 amino acids; 56484 Da
Subunit : Interacts with TP53 and CUX1/CDP (By similarity). Interacts with HDAC1. Part of acorepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2
Subcellular location : Nucleus
Secondary accessions : A8MU25 Q96GJ7 Q9NWY1Alternative splicing : 3 isoforms : Q8N9N5-1 Q8N9N5-2 Q8N9N5-3
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_060339.2 NP_524576.2 ENSEMBL proteins: ENSP00000286122 ENSP00000347290 ENSP00000347125 ENSP00000376903 ENSP00000376902 ENSP00000313421 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: BANP 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
About this table Antibodies for BANP: Assays for BANP:
Protein
Domains/ Families for BANP(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q8N9N5 ProtoNet protein and cluster: Q8N9N5
UniProtKB/Swiss-Prot: BANP_HUMAN, Q8N9N5 Similarity : Belongs to the BANP/SMAR1 family
Gene Function for BANP
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_079837 Applied Biosystems Silencer ® siRNAs for BANP Sigma-Aldrich siRNA for BANP Sigma-Aldrich shRNA for BANP Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_017869                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_017869                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_017869  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_079837 UniProtKB/Swiss-Prot: BANP_HUMAN, Q8N9N5 Function : Controls V(D)J recombination during T-cell development by repressing T-cell receptor(TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), anATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcriptionby recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels.Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest(By similarity)
1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
IEA --
About this table
Pathways & Interactions for BANP
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for BANP 5/10 Interacting proteins for BANP (ENSP00000286122 3 ) via UniProtKB, MINT, and/or STRING (see all 10
)About this table 5 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006350 transcription
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0007275 multicellular organismal development
IEA -- GO:0016568 chromatin modification
IEA -- GO:0045786 negative regulation of cell cycle
IEA --
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Drugs & Compounds for BANP (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for BANP
Transcripts for BANP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_079837 Sigma-Aldrich siRNA for BANP Sigma-Aldrich shRNA for BANP Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_017869 NM_079837
REFSEQ mRNAs for BANP gene (2 alternative transcripts): NM_017869.3 NM_079837.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_017869 NM_079837
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_017869                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_017869                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_017869  
Additional cDNA sequence: AK001039.1 AK094158.1 AK125232.1 AK293472.1 AK297945.1 AK315089.1 AK315535.1 BC009424.1 BC018247.1
24 DOTS entries : DT.92425420 DT.100706645 DT.95378441 DT.95098443 DT.451949 DT.120686119 DT.100832434 DT.91817711 DT.95275274 DT.95295952 DT.120686201 DT.120686143 DT.95227137 DT.95275276 DT.100688898 DT.120686137 DT.100740200 DT.100761656 DT.100780216 DT.100780217 DT.100832432 DT.102829785 DT.120686187 DT.95153065
24/125 AceView cDNA sequences (see all 125
):NM_017869 CD673246 BX360845 BQ949742 AA902510 NM_079837 BE018428 BM839530 BX950991 AK001039 BQ940184 AA368530 AA354067 AW131241 CB961560 BQ650407 AK094158 AL549704 AI680137 BQ650135 BQ653123 BX341113 BQ677433 BQ067439
highest scoring ESTs for BANP :AI738764 AA063445 AI200727 AI362905 AI367317 AI799324 AI992221 AK125232 AL530460 AW137183
Unigene Cluster for BANP: BTG3 associated nuclear protein Hs.461705 [show with all ESTs ] Unigene Representative Sequence: AK125232 GeneLoc Exon Structure 5/11 Alternative Splicing Database (ASD) splice patterns (SP) for BANP (see all 11
) ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ SP1 :     -   -   -   -   -   -         -   -   -   -   -   -   -   -   -               SP2 :                               -                       SP3 :             -   -     -                                   SP4 :           -   -   -     -             -   -   -                   SP5 :                   -                                  
ExUns: 17 ^ 18 SP1 :     SP2 :     SP3 :     SP4 :     SP5 :    
About this scheme ECgene alternative splicing isoforms for BANP 6 Ensembl transcripts including schematic representations : ENST00000286122
ENST00000355163
ENST00000355022
ENST00000393208
ENST00000393207
ENST00000318224
Expression for BANP
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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BANP expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for BANP 1 / 2 / 3
8 probe-sets matching BANP gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AGGCAGGTGTSOURCE GeneReport for Unigene cluster: Hs.461705 UniProtKB/Swiss-Prot: BANP_HUMAN, Q8N9N5 Tissue specificity : Down-regulated in breast cancer cell lines
Orthologs for BANP
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for BANP gene from 5/9 species (see all 9
)
About this table Species with no ortholog for BANP ENSEMBL Gene Tree for BANP Paralogs for BANP (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for BANP gene ENSG00000158527 2
SNPs/Variants for BANP (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for BANP (up to first 250kb)
Disorders & Mutations for BANP
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 611564
Medical News for BANP (Possibly Related Articles in
Doctor's Guide )
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--
Publications for BANP (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/17 PubMed articles for BANP gene (see all 17
): Identification and molecular analysis of BANP. (PubMed id 10940556) 1, 2, 3, 4 Birot A.-M.... Rouault J.-P. (2000) Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex. (PubMed id 16166625) 3, 4 Rampalli S.... Chattopadhyay S. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) SMAR1, a novel, alternatively spliced gene product, binds the Scaffold/Matrix-associated region at the T cell receptor beta locus. (PubMed id 10950932) 2, 3 Chattopadhyay S....Chen J. (2000) Tumor suppressor SMAR1 represses IkappaBalpha expression and inhibits p65 transactivation through matrix attachment regions. (PubMed id 18981184) 3 Singh K....Chattopadhyay S. (2009) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 3 Kimura K.... Sugano S. (2006) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 3 Rual J.F....Vidal M. (2005) Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif. (PubMed id 15701641) 3 Jalota-Badhwar A....Chattopadhyay S. (2005) Abnormal V(D)J recombination of T cell receptor beta locus in SMAR1 transgenic mice. (PubMed id 15623522) 3 Kaul-Ghanekar R....Chattopadhyay S. (2005) SMAR1 and Cux/CDP modulate chromatin and act as negative regulators of the TCRbeta enhancer (Ebeta). (PubMed id 15371550) 3 Kaul-Ghanekar R....Chattopadhyay S. (2004)
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Genome Databases showing BANP
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing BANP
(According to HUGE )
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Specialized Databases showing BANP (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for BANP (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for BANP:
Recombinant Proteins (BANP ) Antibodies (BANP )
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