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Aliases & Descriptions for BANK1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases BANK 1 , 2 , 5 FLJ20706 1 , 2 , 5 FLJ34204 2
Descriptions B-cell scaffold protein with ankyrin repeats 1 2
Search outside databases for aliases for BANK1 genePrevious GC identifers: GC04P103170 GC04P103069
Summaries for BANK1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for BANK1 : BANK1 is a B-cell-specific scaffold protein and LYN (MIM 165120) tyrosine kinase substrate thatpromotes tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors (see ITPR1; MIM147265) (Yokoyama et al., 2002 [PubMed 11782428]).[supplied by OMIM] UniProtKB/Swiss-Prot: BANK1_HUMAN, Q8NDB2 Function : Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores.Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2
Genomic Location for BANK1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the BANK1 gene Entrez Gene cytogenetic band: 4q24 Ensembl cytogenetic band: 4q24 HGNC cytogenetic band: 4q23 BANK1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P102930:
(about GC identifiers )
Start:
102,930,787 bp from pter
End:
103,214,992 bp from pter
Size:
284,206 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000004.10 NT_016354.18 Proteins for BANK1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: BANK1_HUMAN, Q8NDB2 (See
protein sequence )Recommended Name: B-cell scaffold protein with ankyrin repeats Size : 785 amino acids; 89335 Da
Subunit : Interacts with LYN, ITPR1 and ITPR2
Sequence caution : Sequence=BAA91337.1; Type=Frameshift; Positions=571, 681;
Secondary accessions : A8K7W8 B0F3S2 Q8N5K8 Q8NB56 Q8WYN5 Q9NWP2Alternative splicing : 4 isoforms : Q8NDB2-1 Q8NDB2-2 Q8NDB2-3 Q8NDB2-4
Post-translational modifications:
Phosphorylated on tyrosines upon BCR activation1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_001077376.1 NP_001120979.1 NP_060405.3 ENSEMBL proteins: ENSP00000320509 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for BANK1: Assays for BANK1:
Protein
Domains/ Families for BANK1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q8NDB2 ProtoNet protein and cluster: Q8NDB2
UniProtKB/Swiss-Prot: BANK1_HUMAN, Q8NDB2 Similarity : Contains 2 ANK repeatsSimilarity : Contains 1 DBB domain
Gene Function for BANK1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001127507 Applied Biosystems Silencer ® siRNAs for BANK1 Sigma-Aldrich siRNA for BANK1 Sigma-Aldrich shRNA Panels and shRNA for BANK1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001083907                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001083907                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001083907  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_017935 UniProtKB/Swiss-Prot: BANK1_HUMAN, Q8NDB2 Function : Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores.Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Bank1) : Pathways & Interactions for BANK1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for BANK1 4 Interacting proteins for BANK1 (ENSP00000320509 3 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0042113 B cell activation
IEA --
About this table
Drugs & Compounds for BANK1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for BANK1
Transcripts for BANK1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001127507 Sigma-Aldrich siRNA for BANK1 Sigma-Aldrich shRNA Panels and shRNA for BANK1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001083907 NM_001127507 NM_017935
REFSEQ mRNAs for BANK1 gene (3 alternative transcripts): NM_001083907.1 NM_001127507.1 NM_017935.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001083907 NM_001127507 NM_017935
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001083907                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001083907                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001083907  
Additional cDNA sequence: AB063170.1 AK093024.1 AK292133.1 AK301936.1 AL834291.1 BC032241.1 EU051376.1
5 DOTS entries : DT.440743 DT.100018970 DT.100746931 DT.99933693 DT.100746932
24/65 AceView cDNA sequences (see all 65
):AI018164 BF222011 BX282056 AA809784 AW769825 BF514276 AW574859 AA876117 BF508911 AA732383 AA814890 AA804427 NM_017935 AI864790 AI684654 BE882221 BU188057 BE247533 AI707899 AX747038 AI656515 BG611146 AW408429 AK093024
highest scoring ESTs for BANK1 :AI684654 AA412105 AA804427 AA809784 AA814890 AA827109 AA836191 AI218241 AI692787 AI693674
Unigene Cluster for BANK1: B-cell scaffold protein with ankyrin repeats 1 Hs.480400 [show with all ESTs ] Unigene Representative Sequence: NM_017935 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000322953
Expression for BANK1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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BANK1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for BANK1 1 / 2 / 3
7 probe-sets matching BANK1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TACAAATGCCSOURCE GeneReport for Unigene cluster: Hs.480400 UniProtKB/Swiss-Prot: BANK1_HUMAN, Q8NDB2 Tissue specificity : Expressed in B-cell but not T-cell or myeloid cell lines. Highest expression inCD19(+) B-cells, with very low expression in other cell populations
Orthologs for BANK1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for BANK1 gene from 5 species
About this table Species with no ortholog for BANK1 ENSEMBL Gene Tree for BANK1 Paralogs for BANK1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for BANK1 gene PIK3AP1 2
SNPs/Variants for BANK1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for BANK1 (up to first 250kb)
Disorders & Mutations for BANK1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 610292 disorders : 152700 UniProtKB/Swiss-Prot: BANK1_HUMAN, Q8NDB2
Genetic variations in BANK1 influence susceptibility to systemic lupus erythematosus (SLE)[MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder ofconnective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It isthought to represent a failure of the regulatory mechanisms of the autoimmune system
Human Gene Mutation Database : BANK1 Human Genome Epidemiology Navigator: BANK1 (6 documents)
Medical News for BANK1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for BANK1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/12 PubMed articles for BANK1 gene (see all 12
):
Search for BANK1
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing BANK1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing BANK1
(According to HUGE )
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--
Specialized Databases showing BANK1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for BANK1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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