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Aliases for BANK1 Gene

Aliases for BANK1 Gene

  • B-Cell Scaffold Protein With Ankyrin Repeats 1 2 3
  • BANK 3 6
  • B-Cell Scaffold Protein With Ankyrin Repeats 3
  • FLJ20706 6

External Ids for BANK1 Gene

Previous GeneCards Identifiers for BANK1 Gene

  • GC04P103170
  • GC04P103069
  • GC04P102930
  • GC04P102711
  • GC04P102332
  • GC04P098449

Summaries for BANK1 Gene

Entrez Gene Summary for BANK1 Gene

  • The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for BANK1 Gene

BANK1 (B-Cell Scaffold Protein With Ankyrin Repeats 1) is a Protein Coding gene. Diseases associated with BANK1 include systemic lupus erythematosus and multifocal motor neuropathy. Among its related pathways are B Cell Receptor Signaling Pathway (WikiPathways). An important paralog of this gene is PIK3AP1.

UniProtKB/Swiss-Prot for BANK1 Gene

  • Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BANK1 Gene

Genomics for BANK1 Gene

Regulatory Elements for BANK1 Gene

Genomic Location for BANK1 Gene

Start:
101,411,286 bp from pter
End:
102,074,812 bp from pter
Size:
663,527 bases
Orientation:
Plus strand

Genomic View for BANK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BANK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BANK1 Gene

Proteins for BANK1 Gene

  • Protein details for BANK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDB2-BANK1_HUMAN
    Recommended name:
    B-cell scaffold protein with ankyrin repeats
    Protein Accession:
    Q8NDB2
    Secondary Accessions:
    • A8K7W8
    • B0F3S2
    • Q8N5K8
    • Q8NB56
    • Q8WYN5
    • Q9NWP2

    Protein attributes for BANK1 Gene

    Size:
    785 amino acids
    Molecular mass:
    89282 Da
    Quaternary structure:
    • Interacts with LYN, ITPR1 and ITPR2.
    SequenceCaution:
    • Sequence=BAA91337.1; Type=Frameshift; Positions=571, 681; Evidence={ECO:0000305};

    Alternative splice isoforms for BANK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BANK1 Gene

Proteomics data for BANK1 Gene at MOPED

Post-translational modifications for BANK1 Gene

Other Protein References for BANK1 Gene

No data available for DME Specific Peptides for BANK1 Gene

Domains for BANK1 Gene

Gene Families for BANK1 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for BANK1 Gene

Suggested Antigen Peptide Sequences for BANK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDB2

UniProtKB/Swiss-Prot:

BANK1_HUMAN :
  • Q8NDB2
Domain:
  • Contains 1 DBB domain.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with BANK1: view

Function for BANK1 Gene

Molecular function for BANK1 Gene

UniProtKB/Swiss-Prot Function: Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.

Gene Ontology (GO) - Molecular Function for BANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with BANK1: view

Phenotypes for BANK1 Gene

genes like me logo Genes that share phenotypes with BANK1: view

Animal Models for BANK1 Gene

MGI Knock Outs for BANK1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BANK1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for BANK1 Gene

Localization for BANK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BANK1 Gene COMPARTMENTS Subcellular localization image for BANK1 gene
Compartment Confidence
cytosol 2
cytoskeleton 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BANK1 Gene

Pathways for BANK1 Gene

genes like me logo Genes that share pathways with BANK1: view

Pathways by source for BANK1 Gene

1 BioSystems pathway for BANK1 Gene

Gene Ontology (GO) - Biological Process for BANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042113 B cell activation IEA --
GO:0043410 positive regulation of MAPK cascade IEA --
GO:0045947 negative regulation of translational initiation IEA --
GO:0050869 negative regulation of B cell activation IEA --
GO:0051898 negative regulation of protein kinase B signaling IEA --
genes like me logo Genes that share ontologies with BANK1: view

Transcripts for BANK1 Gene

Unigene Clusters for BANK1 Gene

B-cell scaffold protein with ankyrin repeats 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BANK1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BANK1 Gene

No ASD Table

Relevant External Links for BANK1 Gene

GeneLoc Exon Structure for
BANK1
ECgene alternative splicing isoforms for
BANK1

Expression for BANK1 Gene

mRNA expression in normal human tissues for BANK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BANK1 Gene

This gene is overexpressed in Spleen (13.4), Small Intestine - Terminal Ileum (8.0), and Whole Blood (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for BANK1 Gene

SOURCE GeneReport for Unigene cluster for BANK1 Gene Hs.480400

mRNA Expression by UniProt/SwissProt for BANK1 Gene

Q8NDB2-BANK1_HUMAN
Tissue specificity: Expressed in B-cell but not T-cell or myeloid cell lines. Highest expression in CD19(+) B-cells, with very low expression in other cell populations.
genes like me logo Genes that share expressions with BANK1: view

In Situ Assay Products

Orthologs for BANK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BANK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BANK1 35
  • 99.26 (n)
  • 98.73 (a)
BANK1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BANK1 35
  • 83.59 (n)
  • 74.74 (a)
BANK1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BANK1 35
  • 85.15 (n)
  • 77.72 (a)
BANK1 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bank1 35
  • 77.1 (n)
  • 66.67 (a)
Bank1 16
Bank1 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BANK1 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Bank1 35
  • 75.92 (n)
  • 66.37 (a)
chicken
(Gallus gallus)
Aves BANK1 35
  • 57.13 (n)
  • 43.21 (a)
BANK1 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BANK1 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta stumps 36
  • 8 (a)
OneToMany
Species with no ortholog for BANK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BANK1 Gene

ENSEMBL:
Gene Tree for BANK1 (if available)
TreeFam:
Gene Tree for BANK1 (if available)

Paralogs for BANK1 Gene

Paralogs for BANK1 Gene

genes like me logo Genes that share paralogs with BANK1: view

Variants for BANK1 Gene

Sequence variations from dbSNP and Humsavar for BANK1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs727085 -- 101,960,349(+) TTGAT(A/G)ACGTA intron-variant
rs727086 -- 101,960,400(+) AGAGA(C/T)TTTTG intron-variant
rs767052 -- 102,037,267(-) gttat(G/T)gggct intron-variant
rs901406 -- 101,931,129(-) AAACT(A/G)TGGCA intron-variant
rs918363 -- 101,931,782(+) GTTTG(C/T)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BANK1 Gene

Variant ID Type Subtype PubMed ID
nsv879681 CNV Loss 21882294
dgv1654e1 CNV Complex 17122850
esv2728054 CNV Deletion 23290073
esv2728055 CNV Deletion 23290073
esv2728056 CNV Deletion 23290073
nsv10540 CNV Gain 18304495
essv16616 CNV CNV 17122850
nsv513154 CNV Loss 21212237
esv2032362 CNV Deletion 18987734
esv2728057 CNV Deletion 23290073
esv8035 CNV Loss 19470904
esv271221 CNV Insertion 20981092
nsv879682 CNV Loss 21882294
nsv4440 CNV Insertion 18451855
esv2728058 CNV Deletion 23290073
nsv290436 CNV Insertion 16902084
nsv461596 CNV Gain 19166990
nsv4441 CNV Insertion 18451855
nsv461597 CNV Loss 19166990

Relevant External Links for BANK1 Gene

HapMap Linkage Disequilibrium report
BANK1
Human Gene Mutation Database (HGMD)
BANK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BANK1 Gene

Disorders for BANK1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for BANK1 Gene including...

Search for BANK1 Gene in MalaCards »

(1) OMIM Diseases for BANK1 Gene (610292)

UniProtKB/Swiss-Prot

BANK1_HUMAN
  • Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for BANK1 Gene

Relevant External Links for BANK1

Genetic Association Database (GAD)
BANK1
Human Genome Epidemiology (HuGE) Navigator
BANK1
genes like me logo Genes that share disorders with BANK1: view

Publications for BANK1 Gene

  1. Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus. (PMID: 18204447) Kozyrev S.V. … Alarcon-Riquelme M.E. (Nat. Genet. 2008) 3 4 48
  2. BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor. (PMID: 11782428) Yokoyama K. … Yamamoto T. (EMBO J. 2002) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus. (PMID: 20848568) Sanchez E. … AlarcA^n-Riquelme M.E. (Arthritis Rheum. 2010) 3 48

Products for BANK1 Gene

Sources for BANK1 Gene

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