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Aliases for BANK1 Gene

Aliases for BANK1 Gene

  • B-Cell Scaffold Protein With Ankyrin Repeats 1 2 3 5
  • BANK 3

External Ids for BANK1 Gene

Previous GeneCards Identifiers for BANK1 Gene

  • GC04P103170
  • GC04P103069
  • GC04P102930
  • GC04P102711
  • GC04P102332
  • GC04P098449

Summaries for BANK1 Gene

Entrez Gene Summary for BANK1 Gene

  • The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for BANK1 Gene

BANK1 (B-Cell Scaffold Protein With Ankyrin Repeats 1) is a Protein Coding gene. Diseases associated with BANK1 include Multifocal Motor Neuropathy and Lupus Erythematosus. Among its related pathways are B Cell Receptor Signaling Pathway (WikiPathways). An important paralog of this gene is PIK3AP1.

UniProtKB/Swiss-Prot for BANK1 Gene

  • Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BANK1 Gene

Genomics for BANK1 Gene

Regulatory Elements for BANK1 Gene

Enhancers for BANK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BANK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BANK1 Gene

101,411,286 bp from pter
102,074,812 bp from pter
663,527 bases
Plus strand

Genomic View for BANK1 Gene

Genes around BANK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BANK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BANK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BANK1 Gene

Proteins for BANK1 Gene

  • Protein details for BANK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    B-cell scaffold protein with ankyrin repeats
    Protein Accession:
    Secondary Accessions:
    • A8K7W8
    • B0F3S2
    • Q8N5K8
    • Q8NB56
    • Q8WYN5
    • Q9NWP2

    Protein attributes for BANK1 Gene

    785 amino acids
    Molecular mass:
    89282 Da
    Quaternary structure:
    • Interacts with LYN, ITPR1 and ITPR2.
    • Sequence=BAA91337.1; Type=Frameshift; Positions=571, 681; Evidence={ECO:0000305};

    Alternative splice isoforms for BANK1 Gene


neXtProt entry for BANK1 Gene

Proteomics data for BANK1 Gene at MOPED

Post-translational modifications for BANK1 Gene

Other Protein References for BANK1 Gene

No data available for DME Specific Peptides for BANK1 Gene

Domains & Families for BANK1 Gene

Gene Families for BANK1 Gene

Protein Domains for BANK1 Gene

Suggested Antigen Peptide Sequences for BANK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DBB domain.
  • Contains 2 ANK repeats.
  • Contains 1 DBB domain.
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with BANK1: view

Function for BANK1 Gene

Molecular function for BANK1 Gene

UniProtKB/Swiss-Prot Function:
Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.

Phenotypes for BANK1 Gene

genes like me logo Genes that share phenotypes with BANK1: view

Animal Models for BANK1 Gene

MGI Knock Outs for BANK1:

Animal Model Products

miRNA for BANK1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BANK1 Gene

Localization for BANK1 Gene

Subcellular locations from

Jensen Localization Image for BANK1 Gene COMPARTMENTS Subcellular localization image for BANK1 gene
Compartment Confidence
cytosol 2
cytoskeleton 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BANK1 Gene

Pathways & Interactions for BANK1 Gene

genes like me logo Genes that share pathways with BANK1: view

Pathways by source for BANK1 Gene

1 BioSystems pathway for BANK1 Gene

Gene Ontology (GO) - Biological Process for BANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042113 B cell activation IEA --
GO:0045947 negative regulation of translational initiation IEA --
GO:0050869 negative regulation of B cell activation IEA --
GO:0051898 negative regulation of protein kinase B signaling IEA --
GO:1900165 negative regulation of interleukin-6 secretion IEA --
genes like me logo Genes that share ontologies with BANK1: view

No data available for SIGNOR curated interactions for BANK1 Gene

Drugs & Compounds for BANK1 Gene

No Compound Related Data Available

Transcripts for BANK1 Gene

Unigene Clusters for BANK1 Gene

B-cell scaffold protein with ankyrin repeats 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BANK1 Gene

No ASD Table

Relevant External Links for BANK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BANK1 Gene

mRNA expression in normal human tissues for BANK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BANK1 Gene

This gene is overexpressed in Spleen (x13.4), Small Intestine - Terminal Ileum (x8.0), and Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for BANK1 Gene

This gene is overexpressed in Blymphocyte (41.5) and Peripheral blood mononuclear cells (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BANK1 Gene

SOURCE GeneReport for Unigene cluster for BANK1 Gene Hs.480400

mRNA Expression by UniProt/SwissProt for BANK1 Gene

Tissue specificity: Expressed in B-cell but not T-cell or myeloid cell lines. Highest expression in CD19(+) B-cells, with very low expression in other cell populations.
genes like me logo Genes that share expression patterns with BANK1: view

Protein tissue co-expression partners for BANK1 Gene

- Elite partner

Primer Products

Orthologs for BANK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BANK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BANK1 35
  • 83.59 (n)
  • 74.74 (a)
BANK1 36
  • 79 (a)
(Canis familiaris)
Mammalia BANK1 35
  • 85.15 (n)
  • 77.72 (a)
BANK1 36
  • 76 (a)
(Mus musculus)
Mammalia Bank1 35
  • 77.1 (n)
  • 66.67 (a)
Bank1 16
Bank1 36
  • 64 (a)
(Pan troglodytes)
Mammalia BANK1 35
  • 99.26 (n)
  • 98.73 (a)
BANK1 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Bank1 35
  • 75.92 (n)
  • 66.37 (a)
(Monodelphis domestica)
Mammalia BANK1 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
-- 36
  • 50 (a)
(Gallus gallus)
Aves BANK1 35
  • 57.13 (n)
  • 43.21 (a)
BANK1 36
  • 39 (a)
(Anolis carolinensis)
Reptilia BANK1 36
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta stumps 36
  • 8 (a)
Species with no ortholog for BANK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BANK1 Gene

Gene Tree for BANK1 (if available)
Gene Tree for BANK1 (if available)

Paralogs for BANK1 Gene

Paralogs for BANK1 Gene

genes like me logo Genes that share paralogs with BANK1: view

Variants for BANK1 Gene

Sequence variations from dbSNP and Humsavar for BANK1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10516487 - 101,829,919(-) CCAAG(A/C/T)GATAT intron-variant, reference, missense
rs3733197 - 101,918,130(+) ACCCC(A/G)CACAT reference, missense
rs3113676 - 102,043,886(+) AGTTC(C/T)GTGGT reference, missense
rs976654 -- 101,977,413(-) ATTAG(G/T)GCTGT intron-variant
rs901406 -- 101,931,129(-) AAACT(A/G)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BANK1 Gene

Variant ID Type Subtype PubMed ID
nsv879681 CNV Loss 21882294
dgv1654e1 CNV Complex 17122850
esv2728054 CNV Deletion 23290073
esv2728055 CNV Deletion 23290073
esv2728056 CNV Deletion 23290073
nsv10540 CNV Gain 18304495
essv16616 CNV CNV 17122850
nsv513154 CNV Loss 21212237
esv2032362 CNV Deletion 18987734
esv2728057 CNV Deletion 23290073
esv8035 CNV Loss 19470904
esv271221 CNV Insertion 20981092
nsv879682 CNV Loss 21882294
nsv4440 CNV Insertion 18451855
esv2728058 CNV Deletion 23290073
nsv290436 CNV Insertion 16902084
nsv461596 CNV Gain 19166990
nsv4441 CNV Insertion 18451855
nsv461597 CNV Loss 19166990

Variation tolerance for BANK1 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.40; 90.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BANK1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BANK1 Gene

Disorders for BANK1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for BANK1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
multifocal motor neuropathy
  • mmn
lupus erythematosus
  • systemic lupus erythematosus
systemic lupus erythematosus
  • lupus nephritis
diffuse scleroderma
  • systemic scleroderma
diffuse cutaneous systemic sclerosis
  • diffuse scleroderma
- elite association - COSMIC cancer census association via MalaCards
Search BANK1 in MalaCards View complete list of genes associated with diseases


  • Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:18204447}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Relevant External Links for BANK1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BANK1: view

No data available for Genatlas for BANK1 Gene

Publications for BANK1 Gene

  1. Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus. (PMID: 18204447) Kozyrev S.V. … Alarcon-Riquelme M.E. (Nat. Genet. 2008) 3 4 48 67
  2. The association between BANK1 and TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis. (PMID: 21208380) Fan Y. … Ye D.Q. (Int. J. Immunogenet. 2011) 2 3
  3. C8orf13-BLK is a genetic risk locus for systemic sclerosis and has additive effects with BANK1: results from a large french cohort and meta-analysis. (PMID: 21480188) Coustet B. … Allanore Y. (Arthritis Rheum. 2011) 2 3
  4. BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor. (PMID: 11782428) Yokoyama K. … Yamamoto T. (EMBO J. 2002) 2 3
  5. A nonsynonymous SNP in BANK1 is associated with serum LDL cholesterol levels in three Korean populations. (PMID: 25608828) Hong K.W. … Kim Y. (J. Hum. Genet. 2015) 3

Products for BANK1 Gene

Sources for BANK1 Gene