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BANF2 Gene

protein-coding   GIFtS: 41

GC20P017630
barrier to autointegration factor 2
(Previous name: chromosome 20 open reading frame 179 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C20orf179)
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Aliases &
Descriptions
for BANF2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
BAF-L 1, 2, 3
BAF2 1, 2
BAFL 1, 2, 3
C20orf179 2, 3
MGC62093 2
MGC72082 2
OTTHUMP00000040745 2
OTTHUMP00000040746 2
dJ803K15.1 1
Descriptions
Barrier-to-autointegration factor 2 3
barrier to autointegration factor 2 2
barrier-to-autointegration factor-like 2
chromosome 20 open reading frame 179 1
External Ids
HGNC: 161721
Entrez Gene: 1408362
UniProtKB: Q9H5033
Ensembl: ENSG000001258887
Search outside databases for aliases for BANF2 gene

Summaries
for BANF2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: BAFL_HUMAN, Q9H503
Function: May play a role in BANF1 regulation and influence tissue-specific roles of BANF1

Genomic Location
for BANF2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12.1   Ensembl cytogenetic band:  20p12.1   HGNC cytogenetic band: 20p12.1

BANF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P017630:     (about GC identifiers)

Start:
 17,628,593 bp from pter
End:
 17,664,517 bp from pter
Size:
 35,925 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000020.9  NT_011387.8  

Proteins
for BANF2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: BAFL_HUMAN, Q9H503 (See protein sequence)
Recommended Name: Barrier-to-autointegration factor-like protein  
Size: 90 amino acids; 10309 Da
Subunit: Homodimer. Heterodimerizes with BANF1
Subcellular location: Nucleus. Cytoplasm
Caution: In contrast to BANF1, it does not seems to bind DNA
Secondary accessions: Q7Z4M6

REFSEQ proteins (3 alternative transcripts): 
NP_001014977.2  NP_001152967.1  NP_848572.3  


ENSEMBL proteins: 
ENSP00000367036 ENSP00000246090 


Human Recombinant Proteins 
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Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
GO:0005737 cytoplasm IEA--
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Antibodies for BANF2: 
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for BANF2

Assays for BANF2: 
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Protein Domains/
Families
for BANF2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR004122 BAF_prot


   GeneDecks  BANF2 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9H503

ProtoNet protein and cluster: Q9H503

1 Blocks protein family: IPB004122 Barrier to autointegration factor

UniProtKB/Swiss-Prot: BAFL_HUMAN, Q9H503
Similarity: Belongs to the BAF family

Gene Function
for BANF2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (BANF2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (C20orf179)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001014977

              Applied Biosystems Silencer® siRNAs for BANF2

              Sigma-Aldrich siRNA and siRNA Panels for BANF2  
                     Sigma-Aldrich shRNA for BANF2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for BANF2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001014977
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001014977
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001014977 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001014977

UniProtKB/Swiss-Prot: BAFL_HUMAN, Q9H503
Function: May play a role in BANF1 regulation and influence tissue-specific roles of BANF1

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding IEA--
About this table

Pathways & Interactions
for BANF2

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for BANF2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BANF2

Transcripts
for BANF2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (BANF2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (C20orf179)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001014977

              Sigma-Aldrich siRNA and siRNA Panels for BANF2  
                     Sigma-Aldrich shRNA for BANF2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001014977  NM_178477  

REFSEQ mRNAs for BANF2 gene (3 alternative transcripts): 

NM_001014977.3   NM_001159495.1   NM_178477.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001014977  NM_178477  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001014977
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001014977
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001014977 

Additional cDNA sequence: 

BC054871.1 BC062735.1 

2 DOTS entries:

DT.309388  DT.87046979 

19 AceView cDNA sequences:

AA397912 AW022487 NM_178477 BC062735 AI150321 AA442269 BC054871 BV205077 
AA862555 AI066604 AA629341 AA382909 AI075928 AI204602 BU561046 AA394107 
BG459855 BU853192 BQ428794 

Unigene Cluster for BANF2:

Barrier to autointegration factor 2
Hs.115366  [show with all ESTs]
Unigene Representative Sequence: BQ428794


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for BANF2

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:              -                           
SP2:              -     -                     
SP3:                                          

About this scheme

ECgene alternative splicing isoforms for BANF2

2 Ensembl transcripts including schematic representations:
ENST00000377805  ENST00000246090  

Expression
for BANF2

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BANF2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for BANF2

1 / 2

3 probe-sets matching BANF2 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
88552_at2 U95-E 1 1.00 1.00 1.00 1.00 -- -- -- -- --

232766_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

232766_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  BANF2 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.115366

UniProtKB/Swiss-Prot: BAFL_HUMAN, Q9H503
Tissue specificity: Expressed strongly in testis and pancreas. Also detected in brain, colon,
liver, lung, ovary, placenta, prostate, small intestine, spleen and thymus. Not detected in heart,
kidney and skeletal muscle

Orthologs
for BANF2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for BANF2 gene from 5 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 BANF21   -- barrier to autointegration factor 2 88.89(n)
90(a)		 485755  XM_542878.2  XP_542878.2 
chimpanzee
(Pan troglodytes)		 BANF21   -- barrier to autointegration factor 2 99.26(n)
98.89(a)		 470011  XM_001139094.1  XP_001139094.1 
cow
(Bos taurus)		 BANF21   -- barrier to autointegration factor 2 84.07(n)
85.56(a)		 538599  NM_001040559.1  NP_001035649.1 
rat
(Rattus norvegicus)		 Banf21   -- barrier to autointegration factor 2 85.93(n)
87.78(a)		 296198  XM_215865.4  XP_215865.3 
mouse
(Mus musculus)		 Banf21, 5 25
 barrier to autointegration factor 21, 5 85.93(n)1
88.89(a)1		 4031711  NM_207275.11  NP_997158.11 
 AA0889525  AK0768635  (see all 7)
About this table        Species with no ortholog for BANF2

ENSEMBL Gene Tree for BANF2

Paralogs
for BANF2

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for BANF2 gene
BANF12  

SNPs/Variants
for BANF2

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/299 NCBI SNPs in BANF2 are shown (see all 299 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 123)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 20 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs22778681,2
A,C,F,H17628544(-) AGGTCA/GGGGGT 2 -- ng514Minor allele frequency- G:0.31EU EA WA 392
rs10539931,2
A,C,F,H17664416(+) GCAGAC/GTTCTC 2 T/S mis1 ese314Minor allele frequency- G:0.40MN EU EA WA NA 1454
--
rs9134571,2
A,C,F,H17664657(+) aatccT/Ccttag 2 -- ng313Minor allele frequency- C:0.38EU EA 300
rs61361691,2
A,C,F,H17627400(+) GACAAT/CGTCAG 2 -- ng518Minor allele frequency- C:0.46EU EA WA 834
rs31945511,2
A,C,F,H17628672(+) CTGCCG/AGCTGC 2 -- ut51 ese34Minor allele frequency- A:0.31EU EA WA 376
rs48146401,2
A,C,F,H17653677(+) TGGACG/AACATG 2 N/D mis112Minor allele frequency- A:0.04EU EA WA NA 1052
rs9134581,2
C,F,H17664827(+) tgctaT/Cctcac 2 -- ng318Minor allele frequency- C:0.07EU EA WA 838
rs60807851,2
C,F,H17627998(+) CCAACA/GATGGA 2 -- ng517Minor allele frequency- G:0.08EU EA WA NA 560
--
rs10753471,2
A17664759(-) atgacC/Taatac 2 -- ng310--------
rs60449591,2
H17627342(+) AGTCAG/AATTAC 2 -- ng514Minor allele frequency- A:0.00EU EA WA 420
About this table

HapMap Linkage Disequilibrium images for BANF2 (up to first 250kb)

Disorders & Mutations
for BANF2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for BANF2

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for BANF2

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

5 PubMed articles for BANF2 gene:

Search for BANF2

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing BANF2

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 140836 HGNC: 16172 AceView: C20orf179 Ensembl:ENSG00000125888 euGenes: HUgn140836
ECgene: BANF2 H-InvDB: BANF2

Other Databases showing BANF2

(According to HUGE)
About This Section

   --

Specialized Databases showing BANF2

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for BANF2

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for BANF2

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for BANF2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Search Novus for antibodies for BANF2

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