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Aliases & Descriptions for BAMBI
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| NMA 1, 2, 3, 5 | | OTTHUMP00000019384 2 |
| | | Descriptions |
|---|
| BMP and activin membrane-bound inhibitor 2 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) 2 | | Non-metastatic gene A protein 2, 3 | | Putative transmembrane protein NMA 3 | | putative transmembrane protein 2 |
|
| | Search outside databases for aliases for BAMBI genePrevious GC identifer: GC10P028970 |
Summaries for BAMBI(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for BAMBI: This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq] UniProtKB/Swiss-Prot: BAMBI_HUMAN, Q13145Function: Negatively regulates TGF-beta signaling |
Genomic Location for BAMBI
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the BAMBI gene 
Entrez Gene cytogenetic band: 10p12.3-p11.2 Ensembl cytogenetic band: 10p11.23 HGNC cytogenetic band: 10p12.3-p11.2BAMBI Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P029006:
(about GC identifiers)
Start:
|
29,006,430 bp from pter |
End:
|
29,011,874 bp from pter |
Size:
|
5,445 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_008705.15
| Proteins for BAMBI
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: BAMBI_HUMAN, Q13145 (See
protein sequence)Recommended Name: BMP and activin membrane-bound inhibitor homolog precursor Size: 260 amino acids; 29108 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Developmental stage: Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell linesREFSEQ proteins: NP_036474.1
ENSEMBL proteins: ENSP00000364683
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for BAMBI: Assays for BAMBI: | Protein
Domains/ Families for BAMBI(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q13145
ProtoNet protein and cluster: Q13145 1 Blocks protein family: IPB009345 BMP and activin membrane-bound inhibitor
UniProtKB/Swiss-Prot: BAMBI_HUMAN, Q13145Similarity: Belongs to the BAMBI family | Gene Function for BAMBI
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012342
Applied Biosystems Silencer® siRNAs for BAMBI
Sigma-Aldrich siRNA for BAMBI  Sigma-Aldrich shRNA for BAMBI  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012342                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012342                                  untagged cDNA clones in CMV expression vector (see all 2): NM_012342 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_012342
UniProtKB/Swiss-Prot: BAMBI_HUMAN, Q13145Function: Negatively regulates TGF-beta signaling5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Bambi):
| Pathways & Interactions for BAMBI
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for BAMBI 
5/37 Interacting proteins for BAMBI (Q131452 ENSP000003646833) via UniProtKB, MINT, and/or STRING (see all 37
)About this table
|
Drugs & Compounds for BAMBI(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for BAMBI 2 Novoseek chemical compound relationships for BAMBI gene
About this table
|
Transcripts for BAMBI(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012342
Sigma-Aldrich siRNA for BAMBI  Sigma-Aldrich shRNA for BAMBI  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_012342 REFSEQ mRNAs for BAMBI gene: NM_012342.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_012342               OriGene GFP tagged cDNA clone in CMV expression vector: NM_012342                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_012342                                  untagged cDNA clones in CMV expression vector (see all 2): NM_012342  Additional cDNA sequence: AK223065.1 AK290639.1 BC019252.1 BT006820.1 CR592169.1 CR592969.1 CR598096.1 CR598415.1 CR605506.1 CR616386.1 CR617546.1 U23070.1 10 DOTS entries: DT.315386 DT.95289042 DT.100777678 DT.100726383 DT.100777669 DT.100777677 DT.121254370 DT.95289040 DT.95289076 DT.95289044 24/235 AceView cDNA sequences (see all 235
):CA454944 AA459954 BX335397 BM761955 AW949368 AA317353 BQ434899 CR598096 CN482969 BM718610 BM708847 CR598415 BQ426042 BM661838 BU733078 BQ425142 BQ640107 AI634158 BM691702 BI495550 CD676688 Z39158 CR606572 CA413611
highest scoring ESTs for BAMBI:U23070 AA307268 AA460043 AA687447 AA933689 AI004343 AI018637 AI081652 AI147162 AI220785 Unigene Cluster for BAMBI: BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) Hs.533336 [show with all ESTs]Unigene Representative Sequence: NM_012342
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000375533
|
Expression for BAMBI
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| BAMBI expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for BAMBI
1 / 2 / 3 3 probe-sets matching BAMBI gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TACAGTGGGC
SOURCE GeneReport for Unigene cluster: Hs.533336
Expression variation in blood from EXPOLDB for BAMBI UniProtKB/Swiss-Prot: BAMBI_HUMAN, Q13145Tissue specificity: High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested |
Orthologs for BAMBI
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BAMBI gene from 5/10 species (see all 10
)
About this table Species with no ortholog for BAMBI
ENSEMBL Gene Tree for BAMBI | Paralogs for BAMBI(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for BAMBI(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
The following additional 32 SNP(s) have been
found in Applied Biosystems data source: (Click
for
Applied Biosystems TaqMan ® Genotyping Assay)
HapMap Linkage Disequilibrium images for BAMBI (up to first 250kb)
|
Disorders & Mutations for BAMBI
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604444
8 Novoseek disease relationships for BAMBI gene
About this table
|
Medical News for BAMBI(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for BAMBI (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/75 PubMed articles for BAMBI gene (see all 75
):- Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts. (PubMed id 8621228)1, 2, 3, 4 Degen W.G.J.... Bloemers H.P.J. (1996)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)3, 4 Zhang Z. and Henzel W.J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)3, 4 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling. (PubMed id 15240101)1, 3 Sekiya T....Akiyama T. (2004)
- The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling. (PubMed id 18838381)1, 3 Lin Z....Chen Y.G. (2008)
- Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. (PubMed id 18756595)3 Togo N....Akiyama T. (2008)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)3 Rual J.F....Vidal M. (2005)
- Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. (PubMed id 14660579)3 Sekiya T....Akiyama T. (2004)
- Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PubMed id 12107411)3 Wistow G.... Peterson K. (2002)
|
Search for BAMBI
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing BAMBI
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing BAMBI
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BAMBI(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for BAMBI(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for BAMBI:

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Incremental update: 13 Oct 2009
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