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BAMBI Gene

protein-coding   GIFtS: 57

GC10P029006
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
NMA 1, 2, 3, 5
OTTHUMP00000019384 2
Descriptions
BMP and activin membrane-bound inhibitor 2
BMP and activin membrane-bound inhibitor homolog (Xenopus
laevis) 2
Non-metastatic gene A protein 2, 3
Putative transmembrane protein NMA 3
putative transmembrane protein 2
External Ids
HGNC: 302511
Entrez Gene: 258052
UniProtKB: Q131453
Ensembl: ENSG000000957397
Search outside databases for aliases for BAMBI gene

Previous GC identifer: GC10P028970

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for BAMBI:
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming
growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in
many developmental and pathological processes. The encoded protein however is a pseudoreceptor,
lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins
in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the
suggestion that the encoded protein may function to limit the signaling range of the TGF-beta
family during early embryogenesis. [provided by RefSeq]

UniProtKB/Swiss-Prot: BAMBI_HUMAN, Q13145
Function: Negatively regulates TGF-beta signaling

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BAMBI gene  

Entrez Gene cytogenetic band: 10p12.3-p11.2   Ensembl cytogenetic band:  10p11.23   HGNC cytogenetic band: 10p12.3-p11.2

BAMBI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P029006:     (about GC identifiers)

Start:
29,006,430 bp from pter
End:
29,011,874 bp from pter
Size:
5,445 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000010.9  NT_008705.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BAMBI_HUMAN, Q13145 (See protein sequence)
Recommended Name: BMP and activin membrane-bound inhibitor homolog precursor  
Size: 260 amino acids; 29108 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Developmental stage: Expression in poorly metastatic human melanoma cell lines; no expression in
highly metastatic human melanoma cell lines

REFSEQ proteins: NP_036474.1  

ENSEMBL proteins: 
ENSP00000364683 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (BAMBI)
Human Recombinant Proteins from Abnova (BAMBI)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IDA10942595
GO:0016020 membrane IEA--
GO:0016021 integral to membrane TAS8621228
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Antibodies for BAMBI: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for BAMBI
R&D Systems Antibodies for BAMBI (BAMBI/NMA)
Antibodies from Abcam (BAMBI), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (BAMBI)
Novus Biologicals Antibody for BAMBI

Assays for BAMBI: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR009345 BAMBI


   GeneDecks  BAMBI for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q13145

ProtoNet protein and cluster: Q13145

1 Blocks protein family: IPB009345 BMP and activin membrane-bound inhibitor

UniProtKB/Swiss-Prot: BAMBI_HUMAN, Q13145
Similarity: Belongs to the BAMBI family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (BAMBI)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (BAMBI)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012342

              Applied Biosystems Silencer® siRNAs for BAMBI

              Sigma-Aldrich siRNA for BAMBI  
                     Sigma-Aldrich shRNA for BAMBI  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for BAMBI
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012342
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012342
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_012342 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_012342

UniProtKB/Swiss-Prot: BAMBI_HUMAN, Q13145
Function: Negatively regulates TGF-beta signaling

5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Bambi):

craniofacialgrowth/sizelimbs/digits/tailnormalskeleton

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Millipore Pathway for BAMBI
 Signal transduction Activin A signaling regulation

   GeneDecks  BAMBI for the pathways selected above  
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 Gene Network CentralTM Interacting Genes and Proteins Network for  BAMBI 


5/37 Interacting proteins for BAMBI (Q131452 ENSP000003646833) via UniProtKB, MINT, and/or STRING (see all 37 )
InteractantInteraction Details
GeneCardExternal ID(s)
SOX30O949932MINT-66314
BMPR1AENSP000003611073STRING (score=.967)
BMPR1BENSP000002645683STRING (score=.967)
BMPR2ENSP000003637083STRING (score=.967)
BMP4ENSP000002454513STRING (score=.966)
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BAMBI
2 Novoseek chemical compound relationships for BAMBI gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
tungsten 61.70 2 10679252 (1), 10739754 (1)
tyrosine 0.00 2 8954911 (1), 10068471 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (BAMBI)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (BAMBI)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012342

              Sigma-Aldrich siRNA for BAMBI  
                     Sigma-Aldrich shRNA for BAMBI  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_012342  

REFSEQ mRNAs for BAMBI gene: 

NM_012342.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_012342  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012342
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012342
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_012342 

Additional cDNA sequence: 

AK223065.1 AK290639.1 BC019252.1 BT006820.1 CR592169.1 CR592969.1 CR598096.1 CR598415.1 
CR605506.1 CR616386.1 CR617546.1 U23070.1 

10 DOTS entries:

DT.315386  DT.95289042  DT.100777678  DT.100726383  DT.100777669  DT.100777677  DT.121254370  DT.95289040 
DT.95289076  DT.95289044 

24/235 AceView cDNA sequences (see all 235 ):

CA454944 AA459954 BX335397 BM761955 AW949368 AA317353 BQ434899 CR598096 
CN482969 BM718610 BM708847 CR598415 BQ426042 BM661838 BU733078 BQ425142 
BQ640107 AI634158 BM691702 BI495550 CD676688 Z39158 CR606572 CA413611 

highest scoring ESTs for BAMBI:

U23070 AA307268 AA460043 AA687447 AA933689 AI004343 AI018637 AI081652 AI147162 AI220785 

Unigene Cluster for BAMBI:

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
Hs.533336  [show with all ESTs]
Unigene Representative Sequence: NM_012342


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000375533  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BAMBI expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for BAMBI

1 / 2 / 3

3 probe-sets matching BAMBI gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
37678_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U23070 1.00 1.00 1.00 1

203304_at2, 3 U133-A 1 1.00 1.00 -- -- NM_012342 0.60 1.00 0.82 1

203304_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  BAMBI for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TACAGTGGGC

SOURCE GeneReport for Unigene cluster: Hs.533336

Expression variation in blood from EXPOLDB for BAMBI

UniProtKB/Swiss-Prot: BAMBI_HUMAN, Q13145
Tissue specificity: High expression in kidney medulla, placenta and spleen; low in kidney cortex,
liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3
out of 11 melanoma metastases tested

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for BAMBI gene from 5/10 species (see all 10 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
BAMBI1   -- BMP and activin membrane-bound inhibitor homolog (Xenopus more 92.05(n)
96.54(a)
487081  XM_544209.2  XP_544209.1 
chimpanzee
(Pan troglodytes)
BAMBI1   -- BMP and activin membrane-bound inhibitor homolog (Xenopus more 99.02(n)
98.73(a)
745034  XM_001150397.1  XP_001150397.1 
cow
(Bos taurus)
BAMBI1   -- BMP and activin membrane-bound inhibitor homolog (Xenopus more 87.56(n)
94.62(a)
530147  NM_001046309.1  NP_001039774.1 
rat
(Rattus norvegicus)
Bambi1   -- BMP and activin membrane-bound inhibitor, homolog (Xenopus more 88.85(n)
95.77(a)
83837  NM_139082.2  NP_620782.1 
mouse
(Mus musculus)
Bambi1, 5 185
BMP and activin membrane-bound inhibitor, homolog (Xenopus more1, 5 88.33(n)1
93.08(a)1
680101  NM_026505.21  NP_080781.11 
 AA1628075  AF1534405  (see all 14)
About this table        Species with no ortholog for BAMBI

ENSEMBL Gene Tree for BAMBI
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


8 NCBI SNPs in BAMBI are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs37583651,2
A,C,F,H29005779(+) TAGCCC/GGCTAC 1 -- ng516Minor allele frequency- G:0.30MN EA EU WA 768
rs6108201,2
A,C,F29005651(+) TGATCT/AGGGTC 1 -- ng517Minor allele frequency- A:0.49EA NA MN 594
rs37583621,2
F,H29005411(+) GCTCTG/CGCAGA 1 -- ng514Minor allele frequency- C:0.04EU EA WA 416
rs37583641,2
F29005672(+) TTTGCC/TAGCCA 1 -- ng511Minor allele frequency- T:0.00EA 1504
--
rs79189811,2
--29005477(+) GAGAGA/GATAAA 1 -- ng51 trp30--------
--
rs723372271,2
--29004852(+) AAAAA-/AAAAAAA 1 -- ng510--------
--
rs115963621,2
--29004817(+) ccagcC/Ttgggc 1 -- ng510--------
--
rs344813091,2
--29004868(+) AAAAG-/AAATCTTG 1 -- ng510--------
About this table
The following additional 32 SNP(s) have been found in Applied Biosystems data source:
(Click for Applied Biosystems TaqMan ® Genotyping Assay)


 rs675558 rs17832472 rs56281747 rs17832466 rs663378 rs11007192 rs12570151
 rs17753457 rs10826489 rs655766 rs624032 rs12411558 rs12355072 rs608083
 rs1050581 rs4749334 rs1153 rs1888085 rs34535452 rs1085557 rs813095
 rs61729233 rs12251330 rs660371 rs10826491 rs17686247 rs10826490 rs12219636
 rs9663912 rs4747626 rs11007191 rs619155

HapMap Linkage Disequilibrium images for BAMBI (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604444

8 Novoseek disease relationships for BAMBI gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
wolfram syndrome 80.92 2 10679252 (1), 10739754 (1)
optic atrophy 66.63 1 10679252 (1)
batten disease 60.89 1 11590129 (1)
neurodegenerative diseases 48.63 1 11590129 (1)
diabetes mellitus 25.08 1 10679252 (1)
melanoma 0.00 9 8621228 (3), 8170938 (1)
tumors 0.00 4 8170938 (1), 15893603 (1), 18838381 (1)
metastasis 0.00 1 8621228 (1)
About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/75 PubMed articles for BAMBI gene (see all 75 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 25805 HGNC: 30251 AceView: BAMBI Ensembl:ENSG00000095739 euGenes: HUgn25805
ECgene: BAMBI H-InvDB: BAMBI
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for BAMBI Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for BAMBI:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for BAMBI-related products

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 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for BAMBI Antibodies for BAMBI
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for BAMBI Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

 Recombinant Proteins (BAMBI)
 Antibodies (BAMBI)
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 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
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 Recombinant Proteins
(BAMBI)
 Antibodies (BAMBI)
 Search OriGene for BAMBI
 Search Tocris compounds for BAMBI




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for BAMBI

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