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Aliases for BAMBI Gene

Aliases for BAMBI Gene

  • BMP And Activin Membrane-Bound Inhibitor 2 3
  • NMA 3 4 6
  • Putative Transmembrane Protein NMA 3 4
  • Non-Metastatic Gene A Protein 3 4
  • BMP And Activin Membrane-Bound Inhibitor Homolog (Xenopus Laevis) 2
  • BMP And Activin Membrane-Bound Inhibitor Homolog 3

External Ids for BAMBI Gene

Summaries for BAMBI Gene

Entrez Gene Summary for BAMBI Gene

  • This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAMBI Gene

BAMBI (BMP And Activin Membrane-Bound Inhibitor) is a Protein Coding gene. Diseases associated with BAMBI include gnathodiaphyseal dysplasia and cohen syndrome. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include frizzled binding and type II transforming growth factor beta receptor binding.

UniProtKB/Swiss-Prot for BAMBI Gene

  • Negatively regulates TGF-beta signaling

Gene Wiki entry for BAMBI Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAMBI Gene

Genomics for BAMBI Gene

Genomic Location for BAMBI Gene

Start:
28,677,342 bp from pter
End:
28,682,939 bp from pter
Size:
5,598 bases
Orientation:
Plus strand

Genomic View for BAMBI Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAMBI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAMBI Gene

Regulatory Elements for BAMBI Gene

Proteins for BAMBI Gene

  • Protein details for BAMBI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13145-BAMBI_HUMAN
    Recommended name:
    BMP and activin membrane-bound inhibitor homolog
    Protein Accession:
    Q13145
    Secondary Accessions:

    Protein attributes for BAMBI Gene

    Size:
    260 amino acids
    Molecular mass:
    29108 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BAMBI Gene

Proteomics data for BAMBI Gene at MOPED

Post-translational modifications for BAMBI Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys241
  • Glycosylation at Asn87 and Ser114

Other Protein References for BAMBI Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for BAMBI Gene

Domains for BAMBI Gene

Protein Domains for BAMBI Gene

UniProtKB/Swiss-Prot:

BAMBI_HUMAN
Family:
  • Belongs to the BAMBI family.:
    • Q13145
genes like me logo Genes that share domains with BAMBI: view

No data available for Gene Families for BAMBI Gene

Function for BAMBI Gene

Molecular function for BAMBI Gene

UniProtKB/Swiss-Prot Function: Negatively regulates TGF-beta signaling

Gene Ontology (GO) - Molecular Function for BAMBI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004675 transmembrane receptor protein serine/threonine kinase activity --
GO:0005024 transforming growth factor beta-activated receptor activity --
GO:0005109 frizzled binding IPI 18838381
GO:0005114 type II transforming growth factor beta receptor binding TAS 18756595
genes like me logo Genes that share ontologies with BAMBI: view
genes like me logo Genes that share phenotypes with BAMBI: view

Animal Models for BAMBI Gene

MGI Knock Outs for BAMBI:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BAMBI Gene

Localization for BAMBI Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAMBI Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAMBI Gene COMPARTMENTS Subcellular localization image for BAMBI gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for BAMBI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10942595
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BAMBI: view

Pathways for BAMBI Gene

genes like me logo Genes that share pathways with BAMBI: view

Pathways by source for BAMBI Gene

1 Sino Biological pathway for BAMBI Gene
1 GeneGo (Thomson Reuters Life Sciences Research) pathway for BAMBI Gene

Gene Ontology (GO) - Biological Process for BAMBI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0008284 positive regulation of cell proliferation IMP 18838381
GO:0008360 regulation of cell shape IMP 19328798
GO:0010718 positive regulation of epithelial to mesenchymal transition IMP 19328798
GO:0016477 cell migration IDA 19328798
genes like me logo Genes that share ontologies with BAMBI: view

Compounds for BAMBI Gene

(2) Novoseek inferred chemical compound relationships for BAMBI Gene

Compound -log(P) Hits PubMed IDs
tungsten 60.2 2
tyrosine 0 2
genes like me logo Genes that share compounds with BAMBI: view

Transcripts for BAMBI Gene

mRNA/cDNA for BAMBI Gene

Unigene Clusters for BAMBI Gene

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BAMBI Gene

No ASD Table

Relevant External Links for BAMBI Gene

GeneLoc Exon Structure for
BAMBI
ECgene alternative splicing isoforms for
BAMBI

Expression for BAMBI Gene

mRNA expression in normal human tissues for BAMBI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BAMBI Gene

This gene is overexpressed in Ovary (5.7) and Heart - Atrial Appendage (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BAMBI Gene

SOURCE GeneReport for Unigene cluster for BAMBI Gene Hs.533336

mRNA Expression by UniProt/SwissProt for BAMBI Gene

Q13145-BAMBI_HUMAN
Tissue specificity: High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested
genes like me logo Genes that share expressions with BAMBI: view

Orthologs for BAMBI Gene

This gene was present in the common ancestor of chordates.

Orthologs for BAMBI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAMBI 36
  • 99.02 (n)
  • 98.73 (a)
BAMBI 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAMBI 36
  • 87.56 (n)
  • 94.62 (a)
BAMBI 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAMBI 36
  • 92.05 (n)
  • 96.54 (a)
BAMBI 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bambi 36
  • 88.33 (n)
  • 93.08 (a)
Bambi 16
Bambi 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BAMBI 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAMBI 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bambi 36
  • 88.85 (n)
  • 95.77 (a)
chicken
(Gallus gallus)
Aves BAMBI 36
  • 85.97 (n)
  • 93.44 (a)
BAMBI 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BAMBI 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bambi 36
  • 75.9 (n)
  • 84.23 (a)
Str.6638 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5360 36
zebrafish
(Danio rerio)
Actinopterygii bambi 36
bambia 36
  • 70.12 (n)
  • 77.29 (a)
bambia 37
  • 75 (a)
OneToMany
bambib 37
  • 68 (a)
OneToMany
Species with no ortholog for BAMBI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAMBI Gene

ENSEMBL:
Gene Tree for BAMBI (if available)
TreeFam:
Gene Tree for BAMBI (if available)

Paralogs for BAMBI Gene

Selected SIMAP similar genes for BAMBI Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BAMBI: view

No data available for Paralogs for BAMBI Gene

Variants for BAMBI Gene

Sequence variations from dbSNP and Humsavar for BAMBI Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1153 -- 28,682,600(-) ATTTT(A/T)AAAGC utr-variant-3-prime
rs610820 -- 28,676,716(+) TGATC(A/T)GGGTC upstream-variant-2KB
rs675558 -- 28,679,377(+) AGGGG(A/G)CAGAA intron-variant
rs786873 -- 28,677,702(+) ACCGG(A/G)AAACT utr-variant-5-prime
rs813095 -- 28,677,687(+) GGCCG(A/C)CGACG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for BAMBI Gene

Variant ID Type Subtype PubMed ID
esv2734606 CNV Deletion 23290073
nsv894990 CNV Loss 21882294

Relevant External Links for BAMBI Gene

HapMap Linkage Disequilibrium report
BAMBI

Disorders for BAMBI Gene

(8) Novoseek inferred disease relationships for BAMBI Gene

Disease -log(P) Hits PubMed IDs
wolfram syndrome 80.3 2
optic atrophy 65.7 1
batten disease 60.2 1
neurodegenerative diseases 46.5 1
diabetes mellitus 23.4 1

Relevant External Links for BAMBI

Genetic Association Database (GAD)
BAMBI
Human Genome Epidemiology (HuGE) Navigator
BAMBI
genes like me logo Genes that share disorders with BAMBI: view

No data available for UniProtKB/Swiss-Prot for BAMBI Gene

Publications for BAMBI Gene

  1. Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts. (PMID: 8621228) Degen W.G.J. … Bloemers H.P.J. (Int. J. Cancer 1996) 2 3 4 23
  2. Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. (PMID: 19758997) Yan X. … Chen Y.G. (J. Biol. Chem. 2009) 2 3 23
  3. Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling. (PMID: 15240101) Sekiya T. … Akiyama T. (Biochem. Biophys. Res. Commun. 2004) 3 23
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 49
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4

Products for BAMBI Gene

Sources for BAMBI Gene

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