Aliases for BAMBI Gene
External Ids for BAMBI Gene
Previous GeneCards Identifiers for BAMBI Gene
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for BAMBI Gene
BAMBI (BMP And Activin Membrane-Bound Inhibitor) is a Protein Coding gene. Diseases associated with BAMBI include cohen syndrome and gnathodiaphyseal dysplasia. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include frizzled binding and type II transforming growth factor beta receptor binding.
UniProtKB/Swiss-Prot for BAMBI Gene
Negatively regulates TGF-beta signaling