Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BAMBI Gene

protein-coding   GIFtS: 61
GCID: GC10P029006

BMP And Activin Membrane-Bound Inhibitor

(Previous name: BMP and activin membrane-bound inhibitor homolog (Xenopus...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BMP And Activin Membrane-Bound Inhibitor1 2
NMA2 3 5
Non-Metastatic Gene A Protein2 3
Putative Transmembrane Protein NMA2 3
BMP And Activin Membrane-Bound Inhibitor Homolog (Xenopus Laevis)1
BMP And Activin Membrane-Bound Inhibitor Homolog2

External Ids:    HGNC: 302511   Entrez Gene: 258052   Ensembl: ENSG000000957397   OMIM: 6044445   UniProtKB: Q131453   

Export aliases for BAMBI gene to outside databases

Previous GC identifers: GC10P028970 GC10P028685


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BAMBI Gene:
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth
factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental
and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular
serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as
negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit
the signaling range of the TGF-beta family during early embryogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for BAMBI Gene: 
BAMBI (BMP and activin membrane-bound inhibitor) is a protein-coding gene. Diseases associated with BAMBI include cohen syndrome, and gnathodiaphyseal dysplasia, and among its related super-pathways are Downregulation of TGF-beta receptor signaling and Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer. GO annotations related to this gene include type II transforming growth factor beta receptor binding and frizzled binding.

UniProtKB/Swiss-Prot: BAMBI_HUMAN, Q13145
Function: Negatively regulates TGF-beta signaling

Gene Wiki entry for BAMBI Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BAMBI gene promoter:
         AhR   TBP   USF1   Arnt   POU2F1   POU2F1b   USF-1   POU2F1a   Sox9   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBAMBI promoter sequence
   Search SABiosciences Chromatin IP Primers for BAMBI

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAMBI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.3-p11.2   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12.3-p11.2

BAMBI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAMBI gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P029006:  view genomic region     (about GC identifiers)

Start:
28,966,271 bp from pter      End:
28,971,868 bp from pter
Size:
5,598 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BAMBI_HUMAN, Q13145 (See protein sequence)
Recommended Name: BMP and activin membrane-bound inhibitor homolog precursor  
Size: 260 amino acids; 29108 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Developmental stage: Expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic
human melanoma cell lines

Explore the universe of human proteins at neXtProt for BAMBI: NX_Q13145

Explore proteomics data for BAMBI at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13145

  • BAMBI Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BAMBI Protein Expression
    REFSEQ proteins: NP_036474.1  
    ENSEMBL proteins: 
     ENSP00000364683  
    Reactome Protein details: Q13145
    Human Recombinant Protein Products for BAMBI: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BAMBI (BAMBI/NMA)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for BAMBI
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for BAMBI
    GenScript Custom Purified and Recombinant Proteins Services for BAMBI
    Novus Biologicals BAMBI Protein
    Novus Biologicals BAMBI Lysate
    Sino Biological Recombinant Protein for BAMBI
    Sino Biological Cell Lysate for BAMBI 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BAMBI 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10942595
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    BAMBI for ontologies           About GeneDecksing



    BAMBI Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for BAMBI (BAMBI/NMA)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for BAMBI
    GenScript Custom Superior Antibodies Services for BAMBI
    Novus Biologicals BAMBI Antibodies
    Abcam antibodies for BAMBI
    Cloud-Clone Corp. Antibodies for BAMBI 
    Search ThermoFisher Antibodies for BAMBI
    Search LSBio for Antibodies for BAMBI 

    Assay Products for BAMBI: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BAMBI
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BAMBI
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BAMBI 
    Cloud-Clone Corp. CLIAs for BAMBI


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009345 BMP/activin_membr-bound_inhib

    Graphical View of Domain Structure for InterPro Entry Q13145

    ProtoNet protein and cluster: Q13145

    1 Blocks protein domain: IPB009345 BMP and activin membrane-bound inhibitor

    UniProtKB/Swiss-Prot: BAMBI_HUMAN, Q13145
    Similarity: Belongs to the BAMBI family


    BAMBI for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BAMBI_HUMAN, Q13145
    Function: Negatively regulates TGF-beta signaling

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004675transmembrane receptor protein serine/threonine kinase activity ----
    GO:0005024transforming growth factor beta-activated receptor activity ----
    GO:0005109frizzled binding IPI18838381
    GO:0005114type II transforming growth factor beta receptor binding TAS18756595
         
    BAMBI for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Bambi):
     behavior/neurological  craniofacial  growth/size  integument  limbs/digits/tail 
     normal  skeleton 

    BAMBI for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BAMBI: Bambitm1Mahu Bambitm1.1Jian

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BAMBI 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BAMBI

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BAMBI 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BAMBI 

    miRNA
    Products:
        
    miRTarBase miRNAs that target BAMBI:
    hsa-mir-20b (MIRT004121)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BAMBI
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate BAMBI (see all 32):
    hsa-miR-3678-3p hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-500a hsa-miR-3142 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidBAMBI 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BAMBI
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BAMBI

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BAMBI
    Sirion Biotech Customized adenovirus for overexpression of BAMBI

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for BAMBI (see all 8)
    OriGene ORF clones in mouse, rat for BAMBI
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BAMBI (NM_012342)
    Sino Biological Human cDNA Clone for BAMBI
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BAMBI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAMBI
    Sirion Biotech Customized lentivirus for stable overexpression of BAMBI 
                         Customized lentivirus expression plasmids for stable overexpression of BAMBI 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BAMBI
    Search LifeMap BioReagents cell lines for BAMBI
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAMBI


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BAMBI About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TGF-beta receptor signaling activates SMADs
    Downregulation of TGF-beta receptor signaling0.90
    TGF-beta receptor signaling activates SMADs0.90
    2Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Signaling by TGF-beta Receptor Complex0.61
    3Signaling by GPCR
    Signal Transduction0.55
    4Wnt signaling pathway
    Wnt signaling pathway0.40
    5Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for BAMBI
        Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for BAMBI
        Signal transduction Activin A signaling regulation

    3 BioSystems Pathways for BAMBI
        TGF Beta Signaling Pathway
    TGF-beta receptor signaling
    BMP receptor signaling

    1 Sino Biological Pathway for BAMBI 
        TGF-beta Signaling Pathway

    4        Reactome Pathways for BAMBI
        Signaling by TGF-beta Receptor Complex
    TGF-beta receptor signaling activates SMADs
    Signal Transduction
    Downregulation of TGF-beta receptor signaling


    2         Kegg Pathways  (Kegg details for BAMBI):
        Wnt signaling pathway
    TGF-beta signaling pathway


    BAMBI for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BAMBI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/23 Interacting proteins for BAMBI (Q131452, 3 ENSP000003646834) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SOX30O949932, 3, ENSP000002650074MINT-66314 I2D: score=5 STRING: ENSP00000265007
    SEP15O606132, 3, ENSP000003287294MINT-8270077 I2D: score=2 STRING: ENSP00000328729
    AHSGENSP000003938874STRING: ENSP00000393887
    BMP2ENSP000003681044STRING: ENSP00000368104
    BMP4ENSP000002454514STRING: ENSP00000245451
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0008284positive regulation of cell proliferation IMP18838381
    GO:0008360regulation of cell shape IMP19328798
    GO:0010718positive regulation of epithelial to mesenchymal transition IMP19328798
    GO:0016477cell migration IDA19328798

    BAMBI for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BAMBI for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BAMBI

    2 Novoseek inferred chemical compound relationships for BAMBI gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tungsten 60.2 2 10679252 (1), 10739754 (1)
    tyrosine 0 2 8954911 (1), 10068471 (1)

    Search CenterWatch for drugs/clinical trials and news about BAMBI

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BAMBI gene: 
    NM_012342.2  

    Unigene Cluster for BAMBI:

    BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
    Hs.533336  [show with all ESTs]
    Unigene Representative Sequence: NM_012342
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375533(uc001iuj.1) ENST00000497699
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BAMBI
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate BAMBI (see all 32):
    hsa-miR-3678-3p hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-500a hsa-miR-3142 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidBAMBI 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BAMBI
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BAMBI
    Clone
    Products:
         
    OriGene clones in human, mouse for BAMBI (see all 8)
    OriGene ORF clones in mouse, rat for BAMBI
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BAMBI (NM_012342)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BAMBI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAMBI
    Sirion Biotech Customized lentivirus for stable overexpression of BAMBI 
                         Customized lentivirus expression plasmids for stable overexpression of BAMBI 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BAMBI
    OriGene qSTAR qPCR primer pairs in human, mouse for BAMBI
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BAMBI
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BAMBI
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BAMBI

    Additional mRNA sequence: 

    AK223065.1 AK290639.1 BC019252.1 BT006820.1 U23070.1 

    9 DOTS entries:

    DT.315386  DT.95289042  DT.100777678  DT.100726383  DT.100777669  DT.100777677  DT.95289040  DT.95289044 
    DT.95289076 

    24/235 AceView cDNA sequences (see all 235):

    BI766347 BQ434899 CR605506 AA460043 CR616386 CR617546 AI634158 Z39158 
    BX335397 BQ416921 BU172405 BQ425142 BM661838 BC019252 AI651225 BI495550 
    BQ426042 CR606572 CN482969 CA454944 AA459954 CR592969 BM708847 BM694208 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BAMBI expression in normal human tissues (normalized intensities)      BAMBI embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGTGGGC
    BAMBI Expression
    About this image


    BAMBI expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 9 entries
             Membranous Facial Bones
             HyStem+BMP4-induced MEL2 cells
             skeleton/cranium/chondrocranium   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 6 entries
             Ureter
             visceral organ/bladder/detrusor muscle of bladder   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             Meckel's Cartilage
             HyStem+BMP4-induced E15 cells
             skeleton/cranium/chondrocranium   
     
     Tooth
             visceral organ/oral region/upper jaw   
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Heart Tube
             Human Cardiac Myocytes-adult (HCM-a)   
             heart/atrium   

    See BAMBI Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BAMBI

    SOURCE GeneReport for Unigene cluster: Hs.533336

    UniProtKB/Swiss-Prot: BAMBI_HUMAN, Q13145
    Tissue specificity: High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate
    and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases
    tested

        SABiosciences Expression via Pathway-Focused PCR Array including BAMBI: 
              TGFB/BMP Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BAMBI
    OriGene qSTAR qPCR primer pairs in human, mouse for BAMBI
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BAMBI
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BAMBI
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BAMBI
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAMBI

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BAMBI gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bambi1 , 5 BMP and activin membrane-bound inhibitor, homolog (Xenopus more1, 5 88.33(n)1
    93.08(a)1
      18 (2.30 cM)5
    680101  NM_026505.21  NP_080781.11 
     35079575 
    chicken
    (Gallus gallus)
    Aves BAMBI1 BMP and activin membrane-bound inhibitor homolog (Xenopus more 85.97(n)
    93.44(a)
      428413  NM_001195401.1  NP_001182330.1 
    lizard
    (Anolis carolinensis)
    Reptilia BAMBI6
    BMP and activin membrane-bound inhibitor homolog
    86(a)
    1 ↔ 1
    6(13786022-13790949)
    African clawed frog
    (Xenopus laevis)
    Amphibia AJ243576.12   -- 82.11(n)    AJ243576.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bambi2 BMP and activin membrane-bound inhibitor (Xenopus laevis) more 77.03(n)   83496  BC059419.1 


    ENSEMBL Gene Tree for BAMBI (if available)
    TreeFam Gene Tree for BAMBI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BAMBI gene
    1 SIMAP similar gene for BAMBI using alignment to 1 protein entry:     BAMBI_HUMAN:
    nma

    BAMBI for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/242 SNPs in BAMBI are shown (see all 242)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1497378811,2
    --28964470(+) AGGCCA/GGGTTG 1 -- us2k10--------
    rs1456279491,2
    C--28964484(+) TAACAC/TACCCT 1 -- us2k10--------
    rs3771818741,2
    C--28964499(+) GTTTCC/GTTTAG 1 -- us2k10--------
    rs1488127761,2
    --28964502(+) TCCTTC/TTAGCT 1 -- us2k10--------
    rs1876228061,2
    --28964540(+) TCATTA/GCATAA 1 -- us2k10--------
    rs1920571241,2
    --28964708(+) GACAGA/GTGCCT 1 -- us2k10--------
    rs115963621,2
    H--28964811(+) ccagcC/Ttgggc 1 -- us2k10--------
    rs760007151,2
    C,F--28964838(+) TCTCAG/AAAAAA 1 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs92996071,2
    C,F--28964861(+) aaaaa-/A/AA/ 
    AAA
    /AAAA
    GTCTT
    2 -- us2k1 cds1 trp32NA 4
    rs1452317501,2
    C--28964911(+) TCTAGG/TAGCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BAMBI (28966271 - 28971868 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BAMBI:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734606CNV Deletion23290073
    nsv894990CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BAMBI
    DNA2.0 Custom Variant and Variant Library Synthesis for BAMBI

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604444    OMIM disorders: --

    20/37 diseases for BAMBI (see all 37):    About MalaCards
    cohen syndrome    gnathodiaphyseal dysplasia    wolfram syndrome    megalencephalic leukoencephalopathy with subcortical cysts
    neuronal ceroid-lipofuscinoses    batten disease    optic atrophy    pendred syndrome
    neuronal ceroid lipofuscinosis    friedreich ataxia    temporal lobe epilepsy    retinal disease
    polycystic kidney disease    influenza    neuroendocrine tumor    kidney disease
    paraplegia    kaposi's sarcoma    meningitis    spasticity


    BAMBI for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    8 Novoseek inferred disease relationships for BAMBI gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wolfram syndrome 80.3 2 10679252 (1), 10739754 (1)
    optic atrophy 65.7 1 10679252 (1)
    batten disease 60.2 1 11590129 (1)
    neurodegenerative diseases 46.5 1 11590129 (1)
    diabetes mellitus 23.4 1 10679252 (1)
    metastasis 0 1 8621228 (1)
    tumors 0 4 8170938 (1), 15893603 (1), 18838381 (1)
    melanoma 0 9 8621228 (3), 8170938 (1)

    Genetic Association Database (GAD): BAMBI
    Human Genome Epidemiology (HuGE) Navigator: BAMBI (2 documents)

    Export disorders for BAMBI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BAMBI gene, integrated from 9 sources (see all 90):
    (articles sorted by number of sources associating them with BAMBI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts. (PubMed id 8621228)1, 2, 3, 9 Degen W.G.J.... Bloemers H.P.J. (1996)
    2. Human BAMBI cooperates with Smad7 to inhibit transfor ming growth factor-beta signaling. (PubMed id 19758997)1, 3, 9 Yan X....Chen Y.G. (2009)
    3. Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression. (PubMed id 19998449)1, 4 FAPrsti A....Lenner P. (2010)
    4. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling. (PubMed id 15240101)1, 9 Sekiya T....Akiyama T. (2004)
    9. The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling. (PubMed id 18838381)1, 9 Lin Z....Chen Y.G. (2008)
    10. Genome-Wide Association Study of Pre-Eclampsia Detects Novel Maternal Single Nucleotide Polymorphisms and Copy-Number Variants in Subs ets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cohort. (PubMed id 23551011)1 Zhao L....Dewan A.T. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25805 HGNC: 30251 AceView: BAMBI Ensembl:ENSG00000095739 euGenes: HUgn25805
    ECgene: BAMBI Kegg: 25805 H-InvDB: BAMBI

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BAMBI Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BAMBI Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BAMBI gene:
    Search GeneIP for patents involving BAMBI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for BAMBI (BAMBI/NMA)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for BAMBI (BAMBI/NMA)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for BAMBI  
     OriGene qPCR primer pairs and template standards for BAMBI   OriGene Protein Over-expression Lysate for BAMBI  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for BAMBI  
     OriGene qSTAR qPCR primer pairs in human, mouse for BAMBI   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for BAMBI   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BAMBI   OriGene Custom Protein Services for BAMBI  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BAMBI
     QIAGEN SeqTarget long-range PCR primers for resequencing BAMBI
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAMBI
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BAMBI
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BAMBI
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BAMBI
     GenScript Custom Purified and Recombinant Proteins Services for BAMBI GenScript cDNA clones with any tag delivered in your preferred vector for BAMBI
     GenScript Custom Assay Services for BAMBI GenScript Custom Superior Antibodies Services for BAMBI
     GenScript Custom overexpressing Cell Line Services for BAMBI CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in BAMBI promoter
     Search Chromatin IP Primers for BAMBI
     RT2 qPCR Primer Assay in human, mouse, rat BAMBI
     GNC Network for BAMBI
     SABiosciences PCR Arrays including human, mouse, rat BAMBI
     Search Tocris compounds for BAMBI
     Proteins and Antibodies for BAMBI
     Cell Lysates for BAMBI
     cDNA Clones for BAMBI
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BAMBI antibodies
     BAMBI proteins
     BAMBI lysates
     Antibodies for BAMBI
     See all of Abcam's Antibodies, Kits and Proteins for BAMBI
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for BAMBI
     Antibodies for BAMBI
     ELISAs for BAMBI
     CLIAs for BAMBI
     Search LifeMap BioReagents cell lines for BAMBI
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAMBI
     SwitchGear 3'UTR luciferase reporter plasmids for BAMBI
     SwitchGear Promoter luciferase reporter plasmids for BAMBI
     Search ThermoFisher Antibodies for BAMBI
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAMBI
     inGenious Targeting Laboratory - Custom generated mouse model solutions for BAMBI
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BAMBI
    Customized:
     lentivirus for stable overexpression of BAMBI
     lentivirus expression plasmids for stable overexpression of BAMBI
     adenovirus for overexpression of BAMBI
     Search LSBio for Antibodies for BAMBI
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BAMBI gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4