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BAK1 Gene

protein-coding GIFtS: 68

GC06M033648

BCL2-antagonist/killer 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CDN1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BAK ^¹, ², ³
BAK-LIKE ^²
BCL2L7 ^¹, ², ³
Bcl2-L-7 ^³
CDN1 ^², ³
MGC117255 ^²
MGC3887 ^²
OTTHUMP00000016211 ^²
OTTHUMP00000039620 ^²

Descriptions
Apoptosis regulator BAK ^², ³
BCL2-antagonist/killer 1 ^²
BCL2-like 7 protein ^²
Bcl-2 homologous antagonist/killer ^²
Bcl-2-like protein 7 ^³
pro-apoptotic protein BAK ^²

External Ids
HGNC: 949¹
Entrez Gene: 578²
UniProtKB: Q16611³
Ensembl: ENSG00000030110⁷

Search outside databases for aliases for BAK1 gene

Previous GC identifers: GC06M033542 GC06M033588 GC06M033489

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for BAK1:

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form

oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide

variety of cellular activities. This protein localizes to mitochondria, and functions to induce

apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent

anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This

protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by

RefSeq]

UniProtKB/Swiss-Prot: BAK_HUMAN, Q16611

Function: In the presence of an appropriate stimulus, accelerates programmed cell death by binding

to, and antagonizing the a. repressor BCL2 or its adenovirus homolog E1B 19k protein. Low

micromolar levels of zinc ions inhibit the promotion of apoptosis

Gene Wiki entry for BAK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BAK1 gene

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.31

BAK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M033648: (about GC identifiers)

Start:	33,648,301 bp from pter
End:	33,656,048 bp from pter
Size:	7,748 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BAK_HUMAN, Q16611 (See protein sequence)

Recommended Name: Bcl-2 homologous antagonist/killer

Size: 211 amino acids; 23409 Da

Subunit: Interacts with BCL2A1 (By similarity). Homodimer. Formation of the homodimer is

zinc-dependent. Forms heterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L)

Subcellular location: Membrane; Single-pass membrane protein (Potential)

PDB structures from and Proteopedia :

1BXL (3D)

2IMS (3D)

2IMT (3D)

2JCN (3D)

2YV6 (3D)

Secondary accessions: Q92533

REFSEQ proteins: NP_001179.1

ENSEMBL proteins:

ENSP00000363591 ENSP00000353878 ENSP00000363584

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for BAK1 (BAK)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Bak)
	Human Recombinant Proteins from Abnova (BAK1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	9843949
GO:0005741	mitochondrial outer membrane	EXP	10950869 12721291
GO:0016020	membrane	IEA	--
GO:0046930	pore complex	IDA	9843949

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Antibodies for BAK1:

	Invitrogen Antibodies for BAK1
	Millipore Mono- and Polyclonal Antibodies for the study of BAK1
	Sigma-Aldrich Antibody Arrays and Antibodies for BAK1
	R&D Systems Antibodies for BAK1 (BAK)
	Cell Signaling Technology (CST) Antibodies for BAK1 (Bak)
	Antibodies from Abcam (Bak), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BAK1)
	Novus Biologicals Antibodies for BAK1

Assays for BAK1:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of BAK1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q16611

ProtoNet protein and cluster: Q16611

1 Blocks protein family: IPB000712 Apoptosis regulator Bcl-2 protein

UniProtKB/Swiss-Prot: BAK_HUMAN, Q16611

Domain: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity

and for their interaction with anti-apoptotic members of the Bcl-2 family

Similarity: Belongs to the Bcl-2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001188

Applied Biosystems Silencer® siRNAs for BAK1

Sigma-Aldrich siRNA and siRNA Panels for BAK1

Sigma-Aldrich shRNA Panels and shRNA for BAK1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BAK1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001188
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001188
untagged cDNA clone in CMV expression vector: NM_001188

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001188

UniProtKB/Swiss-Prot: BAK_HUMAN, Q16611

Function: In the presence of an appropriate stimulus, accelerates programmed cell death by binding

to, and antagonizing the a. repressor BCL2 or its adenovirus homolog E1B 19k protein. Low

micromolar levels of zinc ions inhibit the promotion of apoptosis

Genatlas biochemistry entry for BAK1:

BCL2-antagonist/killer 1,BAX subfamily

14 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Bak1):

behavior/neurological	cellular	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	nervous system
normal	renal/urinary system	reproductive system	skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--
GO:0042802	identical protein binding	IPI	15901672
GO:0046872	metal ion binding	IEA	--
GO:0046982	protein heterodimerization activity	IPI	10837489

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for BAK1 (Your Favorite Gene powered by Ingenuity)

Induction of Apoptosis by HIV1
Apoptosis Signaling
Molecular Mechanisms of Cancer

GeneDecks BAK1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BAK1

5/94 Interacting proteins for BAK1 (Q16611^{1, 2} ENSP00000353878³) via UniProtKB, MINT, and/or STRING (see all 94 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VDAC1	P21796², ENSP00000265333³	MINT-15123 MINT-15124 STRING (score=.985)
UBE3A	Q05086², ENSP00000232165³	MINT-69611 MINT-69608 STRING (score=.955)
BCL2	P10415¹, ENSP00000329623³	EBI-519866, EBI-77694 STRING (score=.996)
BID	P55957¹, ENSP00000318822³	EBI-519866, EBI-519672 STRING (score=.996)
MCL1	Q07820¹, ENSP00000358022³	EBI-519866, EBI-1003422 STRING (score=.996)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001836	release of cytochrome c from mitochondria	IDA	9843949
GO:0006917	induction of apoptosis	TAS	10381623
GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	IDA	9843949
GO:0042981	regulation of apoptosis	IEA	--
GO:0043496	regulation of protein homodimerization activity	IDA	9111042

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for BAK1 available from Tocris Bioscience
10/13 Novoseek chemical compound relationships for BAK1 gene (see all 13 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
noxa	73.94	6	18176116 (1), 17569614 (1), 18723481 (1), 17718901 (1) (see all 6)
dutp	44.89	1	12865785 (1)
phosphatidylinositol	22.56	2	9843689 (1)
oxygen	21.75	9	14598320 (1), 17047195 (1), 9592040 (1), 17121941 (1) (see all 9)
tyrosine	8.67	3	10201527 (1), 16116473 (1)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide	3.55	1	18803351 (1)
calcium	1.90	4	16455754 (1), 10210783 (1), 10668461 (1), 11964315 (1)
ceramide	1.76	1	10668461 (1)
glucose	0.54	1	17047195 (1)
estradiol	0.00	2	10800077 (1)

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1 PharmGKB drug compound relationship for BAK1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
doxorubicin	FA	11313874

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001188

Sigma-Aldrich siRNA and siRNA Panels for BAK1

Sigma-Aldrich shRNA Panels and shRNA for BAK1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001188

REFSEQ mRNAs for BAK1 gene:

NM_001188.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001188

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001188
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001188
                                 untagged cDNA clone in CMV expression vector: NM_001188

Additional cDNA sequence:

AK292093.1 AK293547.1 AK303422.1 BC004431.1 CR457419.1 CR600490.1 CR608985.1 CR610168.1

CR615881.1 CR627020.1 U16811.1 U23765.1 X84213.1

11 DOTS entries:

DT.312432 DT.100853480 DT.101982299 DT.100810035 DT.95137351 DT.121304388 DT.100709501 DT.100810036

DT.95137355 DT.97769031 DT.97846728

24/231 AceView cDNA sequences (see all 231 ):

AL559269 BC032789 AU280497 CR600490 CB151540 BQ963042 CA489558 CR608985

BI089592 BX362974 BU543017 BX385444 BU540950 BQ054099 CR615881 AU076473

CD610886 CF530051 BE793110 BU848927 AL522403 BG315161 BQ059009 CR615932

highest scoring ESTs for BAK1:

X84213 BI460835 BI909012 BI911660 BX335068 U16811 U23765 BC004431 AA421826 AA582473

Unigene Cluster for BAK1:

BCL2-antagonist/killer 1

Hs.485139 [show with all ESTs]

Unigene Representative Sequence: CR627020

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000374467 ENST00000360661 ENST00000374460

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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BAK1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BAK1

¹ / ² / ³

4 probe-sets matching BAK1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
846_s_at²^{, 3}	U95-A	1	1.00	1.00	0.90	1.03	U16811	0.80	1.00	0.91	1
1687_s_at²^{, 3}	U95-A	3	1.00	0.46	0.74	1.00	X84213	1.00	0.90	0.95	1
203728_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001188	0.40	0.67	0.55	1
203728_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTCCTCACCT

SOURCE GeneReport for Unigene cluster: Hs.485139
Expression variation in blood from EXPOLDB for BAK1
UniProtKB/Swiss-Prot: BAK_HUMAN, Q16611
Tissue specificity: Expressed in a wide variety of tissues, with highest levels in the heart and
skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BAK1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	Bak1¹	--	BCL2-antagonist/killer 1	89.73(n) 91.94(a)	481744 NM_001020808.1 NP_001018644.1
chimpanzee (Pan troglodytes)	BAK1¹	--	BCL2-antagonist/killer 1	99.37(n) 99.53(a)	462616 XM_518407.2 XP_518407.2
cow (Bos taurus)	BAK1¹	--	BCL2-antagonist/killer 1	86.89(n) 86.26(a)	514090 XM_001253779.1 XP_001253780.1
rat (Rattus norvegicus)	Bak1¹	--	BCL2-antagonist/killer 1	79.43(n) 77.03(a)	116502 NM_053812.1 NP_446264.1
mouse (Mus musculus)	Bak1^{1, 5}	17⁵	BCL2-antagonist/killer 1^{1, 5}	80.22(n)¹ 77.51(a)¹	12018¹ NM_007523.2¹ NP_031549.2¹ AF402616⁵ AF402617⁵ (see all 12)

About this table Species with no ortholog for BAK1

ENSEMBL Gene Tree for BAK1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BAK1 gene

BCL2L2² BCL2² BCL2L1² BAX²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/108 NCBI SNPs in BAK1 are shown (see all 108 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 80)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs5745597^1,2	A,C,F,H	33649316(-)	`CCCTCA/GGCTCT`	1	--	ut3¹ ese³		8		NS EU EA WA NA	730
	rs5745568^1,2	A,C,F,H	33656372(-)	`CCCAGC/ATGAGC`	1	--	ng3¹		15		NS EU EA WA	1650
	rs210134^1,2	C,F,H,O	33648187(+)	`ATTCTG/AGAGGC`	1	--	ng5¹		22		EA NS NA EU WA	3476
--	rs511515^1,2	A,C,F	33649485(+)	`AGGGAG/ACAGAG`	1	--	ut3¹ ese³		5		MN NS NA	360
	rs5745571^1,2	C,F,H	33656144(-)	`ACAGCC/TGCCCT`	1	--	ng3¹		11		NS EU EA WA	1182
	rs4987115^1,2	C,F,H	33651671(-)	`GGTAGC/TCCAGG`	1	A/V	mis¹ ese³		17		MN CSAM EA NS EU WA NA	1564
--	rs8180574^1,2	C,H	33649466(+)	`TTGAGG/AGGGGA`	1	--	ut3¹ ese³		4		EU EA WA	416
--	rs9357161^1,2	A,C	33657381(+)	`ttgagC/Tccagg`	1	--	ng3¹		0	--	--	--	--
--	rs4713635^1,2	A,C	33648458(+)	`GCACTC/GTCACC`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs5745564^1,2	C,F	33656674(-)	`TTTTT-/TGAGAT`	1	--	ng3¹ tfbs³		1		NS	178

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HapMap Linkage Disequilibrium images for BAK1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600516

10/59 Novoseek disease relationships for BAK1 gene (see all 59 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glaucoma absolute	58.11	3	15638362 (2), 15510481 (1)
tumors	48.87	64	10457328 (5), 17476972 (5), 8909234 (3), 16781827 (2) (see all 33)
cancer	48.12	24	12120204 (3), 17047195 (2), 10706081 (2), 10969770 (2) (see all 15)
keratoacanthoma	43.37	1	9415228 (1)
necrosis	41.44	12	10488411 (2), 16528364 (1), 17047195 (1), 10491014 (1) (see all 11)
prostate cancer	37.89	16	16794010 (4), 17062688 (3), 9815595 (1), 12479363 (1) (see all 8)
colon cancer	31.80	3	15824729 (1), 16847458 (1), 10911913 (1)
lymphocytic leukemia chronic b-cell	29.76	2	12176904 (2)
carcinoma squamous cell	27.58	6	11342901 (3), 12579274 (2), 9415228 (1)
melanoma	26.77	6	17302609 (2), 12690298 (1), 15382061 (1), 16529740 (1) (see all 5)

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Human Genome Epidemiology Navigator: BAK1 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/490 PubMed articles for BAK1 gene (see all 490 ):

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. (PubMed id 7715731)^{1, 2, 3, 4} Kiefer M.C....Barr P.J. (1995)
Induction of apoptosis by the Bcl-2 homologue Bak. (PubMed id 7715730)^{2, 3, 4} Chittenden T.... Guild B.C. (1995)
A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. (PubMed id 8521816)^{1, 3, 4} Chittenden T.... Lutz R.J. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. (PubMed id 9020082)^{3, 4} Sattler M.... Fesik S.W. (1997)
Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. (PubMed id 7715729)^{3, 4} Farrow S.N.... Brown R. (1995)
BAK overexpression mediates p53-independent apoptosis inducing effects on human gastric cancer cells. (PubMed id 15248898)^{1, 3} Tong Q.S....Qian W. (2004)
Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak. (PubMed id 16794010)^{1, 3} Castilla C....Saez C. (2006)
Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1. (PubMed id 16529740)^{1, 3} Ihrlund L.S....Shoshan M.C. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 578	HGNC: 949	AceView: BAK1	Ensembl:ENSG00000030110	euGenes: HUgn578
ECgene: BAK1	H-InvDB: BAK1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BAK1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/bak1/

Licensable Technologies for BAK1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BAK1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BAK1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BAK1		Antibodies for BAK1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BAK1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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Antibodies & Assays for BAK1 (Bak)

	Recombinant Proteins (Bak)
	Antibodies (Bak)

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Tocris compounds for BAK1

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Antibodies for BAK1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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BAK1 Gene at Home site.
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BAK1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for BAK1

Summaries
for BAK1

Genomic Location
for BAK1

Proteins
for BAK1

Protein Domains/
Families
for BAK1

Gene Function
for BAK1

Pathways & Interactions
for BAK1

Drugs & Compounds
for BAK1

Transcripts
for BAK1

Expression
for BAK1

Orthologs
for BAK1

Paralogs
for BAK1

SNPs/Variants
for BAK1

Disorders & Mutations
for BAK1

Medical News
for BAK1

Publications
for BAK1

Search for BAK1

Genome Databases showing BAK1

Other Databases showing BAK1

Specialized Databases showing BAK1

Licensable Technologies
for BAK1

Services
for BAK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BAK1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor BAK1

Summariesfor BAK1

Genomic Locationfor BAK1

Proteinsfor BAK1

Protein Domains/Familiesfor BAK1

Gene Functionfor BAK1

Pathways & Interactionsfor BAK1

Drugs & Compoundsfor BAK1

Transcriptsfor BAK1

Expression for BAK1

Orthologsfor BAK1

Paralogsfor BAK1

SNPs/Variantsfor BAK1

Disorders & Mutationsfor BAK1

Medical Newsfor BAK1

Publicationsfor BAK1

Search for BAK1

Genome Databases showing BAK1

Other Databases showing BAK1

Specialized Databases showing BAK1

Licensable Technologiesfor BAK1

Servicesfor BAK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BAK1

Summaries
for BAK1

Genomic Location
for BAK1

Proteins
for BAK1

Protein Domains/
Families
for BAK1

Gene Function
for BAK1

Pathways & Interactions
for BAK1

Drugs & Compounds
for BAK1

Transcripts
for BAK1

Expression
for BAK1

Orthologs
for BAK1

Paralogs
for BAK1

SNPs/Variants
for BAK1

Disorders & Mutations
for BAK1

Medical News
for BAK1

Publications
for BAK1

Licensable Technologies
for BAK1

Services
for BAK1