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Aliases for BAK1 Gene

Aliases for BAK1 Gene

  • BCL2-Antagonist/Killer 1 2 3
  • Apoptosis Regulator BAK 3 4
  • Bcl-2-Like Protein 7 3 4
  • Bcl2-L-7 3 4
  • BCL2L7 3 4
  • CDN1 3 4
  • BAK 3 4
  • Bcl-2 Homologous Antagonist/Killer 3
  • Pro-Apoptotic Protein BAK 3
  • BCL2-Like 7 Protein 3
  • BAK-LIKE 3

External Ids for BAK1 Gene

Previous Symbols for BAK1 Gene

  • CDN1

Summaries for BAK1 Gene

Entrez Gene Summary for BAK1 Gene

  • The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAK1 Gene

BAK1 (BCL2-Antagonist/Killer 1) is a Protein Coding gene. Diseases associated with BAK1 include benign mammary dysplasia and telangiectasis. Among its related pathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BCL2L2.

UniProtKB/Swiss-Prot for BAK1 Gene

  • In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.

Gene Wiki entry for BAK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAK1 Gene

Genomics for BAK1 Gene

Genomic Location for BAK1 Gene

Start:
33,572,546 bp from pter
End:
33,580,296 bp from pter
Size:
7,751 bases
Orientation:
Minus strand

Genomic View for BAK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAK1 Gene

Regulatory Elements for BAK1 Gene

Proteins for BAK1 Gene

  • Protein details for BAK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16611-BAK_HUMAN
    Recommended name:
    Bcl-2 homologous antagonist/killer
    Protein Accession:
    Q16611
    Secondary Accessions:
    • C0H5Y7
    • Q6I9T6
    • Q92533

    Protein attributes for BAK1 Gene

    Size:
    211 amino acids
    Molecular mass:
    23409 Da
    Quaternary structure:
    • Interacts with BCL2A1 (By similarity). Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L). Interacts with myxoma virus protein M11L. Interacts with BOP/C22orf29.

    Three dimensional structures from OCA and Proteopedia for BAK1 Gene

    Alternative splice isoforms for BAK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAK1 Gene

Proteomics data for BAK1 Gene at MOPED

Post-translational modifications for BAK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BAK1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for BAK1 Gene

Domains for BAK1 Gene

Suggested Antigen Peptide Sequences for BAK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16611

UniProtKB/Swiss-Prot:

BAK_HUMAN
Domain:
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family:
    • Q16611
Family:
  • Belongs to the Bcl-2 family.:
    • Q16611
genes like me logo Genes that share domains with BAK1: view

No data available for Gene Families for BAK1 Gene

Function for BAK1 Gene

Molecular function for BAK1 Gene

GENATLAS Biochemistry: BCL2-antagonist/killer 1,BAX subfamily
UniProtKB/Swiss-Prot Function: In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.

Gene Ontology (GO) - Molecular Function for BAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10381623
GO:0031072 heat shock protein binding IEA --
GO:0042802 identical protein binding IPI 15901672
GO:0042803 protein homodimerization activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with BAK1: view
genes like me logo Genes that share phenotypes with BAK1: view

Animal Models for BAK1 Gene

MGI Knock Outs for BAK1:

miRNA for BAK1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BAK1 Gene

Localization for BAK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAK1 Gene

Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAK1 Gene COMPARTMENTS Subcellular localization image for BAK1 gene
Compartment Confidence
mitochondrion 5
cytosol 3
endoplasmic reticulum 2
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion IDA 9843949
GO:0005741 mitochondrial outer membrane TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with BAK1: view

Pathways for BAK1 Gene

genes like me logo Genes that share pathways with BAK1: view

Gene Ontology (GO) - Biological Process for BAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001776 leukocyte homeostasis --
GO:0001782 B cell homeostasis IEA --
GO:0001783 B cell apoptotic process IEA --
GO:0001836 release of cytochrome c from mitochondria IGI 21041309
GO:0001974 blood vessel remodeling IEA --
genes like me logo Genes that share ontologies with BAK1: view

Compounds for BAK1 Gene

(19) ApexBio Compounds for BAK1 Gene

Compound Action Cas Number
2,3-DCPE hydrochloride Selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. [418788-90-6]
ABT-199 Selective Bcl-2 inhibitor [1257044-40-8]
ABT-263 (Navitoclax) orally sellecitive inhibitor of Bcl-2 family proteins [923564-51-6]
ABT-737 novel and potent inhibitor of BCL-2 family proteins [852808-04-9]
Apogossypolone (ApoG2) pan Bcl-2 inhibitor [886578-07-0]
AT-101 R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 [90141-22-3]
Bax channel blocker Potent inhibitor of Bax-mediated mitochondrial cytochrome c release. [335165-68-9]
Bax inhibitor peptide P5 Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria [579492-83-4]
Bax inhibitor peptide V5 Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria [579492-81-2]
Bax inhibitor peptide, negative control Negative control peptide for the Bax inhibitor peptides V5 and P5 [1315378-74-5]
BM-1074 potent and efficacious Bcl-2/Bcl-xL inhibitor [1391108-10-3]
Gambogic Acid activates caspases with EC50 of 0.78-1.64 uM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 [2752-65-0]
HA14-1 non-peptidic ligand of a Bcl-2 [65673-63-4]
Marinopyrrole A novel and specific Mcl-1 inhibitor [1227962-62-0]
MIM1 Inhibitor of Mcl-1
Obatoclax mesylate (GX15-070) potently inhibits BCL-2 family [803712-79-0]
Sabutoclax pan-Bcl-2 inhibitor [1228108-65-3]
TW-37 potent small-molecule inhibitor of BCL-2 [877877-35-5]
WEHI-539 high affinity (subnanomolar) and selectivity for BCL-XL [1431866-33-9]

(53) Novoseek inferred chemical compound relationships for BAK1 Gene

Compound -log(P) Hits PubMed IDs
noxa 81.6 9
phosphatidylserine 54 1
bortezomib 47.6 1
dutp 45.9 1
perillyl alcohol 41.7 5
genes like me logo Genes that share compounds with BAK1: view

Transcripts for BAK1 Gene

Unigene Clusters for BAK1 Gene

BCL2-antagonist/killer 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BAK1 Gene

No ASD Table

Relevant External Links for BAK1 Gene

GeneLoc Exon Structure for
BAK1
ECgene alternative splicing isoforms for
BAK1

Expression for BAK1 Gene

mRNA expression in normal human tissues for BAK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BAK1 Gene

SOURCE GeneReport for Unigene cluster for BAK1 Gene Hs.485139

mRNA Expression by UniProt/SwissProt for BAK1 Gene

Q16611-BAK_HUMAN
Tissue specificity: Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle
genes like me logo Genes that share expressions with BAK1: view

No data available for mRNA differential expression in normal tissues for BAK1 Gene

Orthologs for BAK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BAK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAK1 35
  • 99.37 (n)
  • 99.53 (a)
BAK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAK1 35
  • 86.73 (n)
  • 86.26 (a)
BAK1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAK1 36
  • 77 (a)
OneToOne
LOC481744 35
  • 89.73 (n)
  • 91.94 (a)
mouse
(Mus musculus)
Mammalia Bak1 35
  • 80.22 (n)
  • 77.51 (a)
Bak1 16
Bak1 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BAK1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bak1 35
  • 79.43 (n)
  • 77.03 (a)
chicken
(Gallus gallus)
Aves BAK1 35
  • 69.08 (n)
  • 61.84 (a)
lizard
(Anolis carolinensis)
Reptilia BAK1 36
  • 62 (a)
OneToOne
Species with no ortholog for BAK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BAK1 Gene

ENSEMBL:
Gene Tree for BAK1 (if available)
TreeFam:
Gene Tree for BAK1 (if available)

Paralogs for BAK1 Gene

Paralogs for BAK1 Gene

Selected SIMAP similar genes for BAK1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for BAK1 Gene

genes like me logo Genes that share paralogs with BAK1: view

Variants for BAK1 Gene

Sequence variations from dbSNP and Humsavar for BAK1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs210134 -- 33,572,432(+) ATTCT(A/G)GAGGC downstream-variant-500B
rs210136 -- 33,574,395(+) GAGAA(A/T)GCTCA intron-variant
rs210137 -- 33,574,701(+) TACTC(C/T)GACAC intron-variant
rs210138 -- 33,574,761(+) ACACT(A/G)ATCTA intron-variant
rs210139 -- 33,575,632(+) GATAC(A/C)AGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAK1 Gene

Variant ID Type Subtype PubMed ID
nsv519079 CNV Loss 19592680
nsv885770 CNV Loss 21882294

Relevant External Links for BAK1 Gene

HapMap Linkage Disequilibrium report
BAK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAK1 Gene

Disorders for BAK1 Gene

(1) University of Copenhagen DISEASES for BAK1 Gene

(61) Novoseek inferred disease relationships for BAK1 Gene

Disease -log(P) Hits PubMed IDs
glaucoma absolute 57.3 3
tumors 49.8 51
cancer 49 20
necrosis 42 13
keratoacanthoma 41.6 1

Relevant External Links for BAK1

Genetic Association Database (GAD)
BAK1
Human Genome Epidemiology (HuGE) Navigator
BAK1
genes like me logo Genes that share disorders with BAK1: view

No data available for UniProtKB/Swiss-Prot for BAK1 Gene

Publications for BAK1 Gene

  1. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. (PMID: 7715731) Kiefer M.C. … Barr P.J. (Nature 1995) 2 3 4 23
  2. BAK, BAX, and NBK/BIK proapoptotic gene alterations in Iranian patients with ataxia telangiectasia. (PMID: 19898928) Isaian A. … Sanati M.H. (J. Clin. Immunol. 2010) 3 23 48
  3. Induction of apoptosis by the Bcl-2 homologue Bak. (PMID: 7715730) Chittenden T. … Guild B.C. (Nature 1995) 2 3 4
  4. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. (PMID: 8521816) Chittenden T. … Lutz R.J. (EMBO J. 1995) 3 4
  5. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PMID: 18636124) Skibola C.F. … Smith M.T. (PLoS ONE 2008) 3 48

Products for BAK1 Gene

  • Addgene plasmids for BAK1

Sources for BAK1 Gene

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