BAK1 Gene
protein-coding GIFtS: 66
GCID: GC06M033541
|
|
BCL2-antagonist/killer 1
(Previous symbol: CDN1)
| |
Aliases
for BAK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BCL2-Antagonist/Killer 11 2 | | BAK-LIKE2 | | BAK1 2 3 | | Bcl-2 Homologous Antagonist/Killer2 | | BCL2L71 2 3 | | Bcl2-L-73 | | CDN11 2 3 | | BCL2-Like 7 Protein2 | | Apoptosis Regulator BAK2 3 | | Pro-Apoptotic Protein BAK2 | | Bcl-2-Like Protein 72 3 | | Bcl2-L-73 |
Export aliases for BAK1 gene to outside databasesPrevious GC identifers: GC06M033542 GC06M033588 GC06M033489 GC06M033648 GC06M033281 |
Summaries
for BAK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BAK1:
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimersand act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This proteinlocalizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of themitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release ofcytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: BAK_HUMAN, Q16611Function: In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizingthe anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ionsinhibit the promotion of apoptosis
Gene Wiki entry for BAK1 (Bcl-2 homologous antagonist killer)
|
Genomic Views
for BAK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BAK1 gene promoter:
STAT5B STAT1 Pax-5 p53 Sp1 HSF1 (long) STAT1beta STAT1alpha HSF1short
Other transcription factors
Search SABiosciences Chromatin IP Primers for BAK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.31BAK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M033541: view genomic region
(about GC identifiers)
Start:
|
33,540,323 bp from pter |
End:
|
33,548,070 bp from pter |
Size:
|
7,748 bases |
Orientation:
|
minus strand |
|
Proteins
for BAK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BAK_HUMAN, Q16611 (See
protein sequence)Recommended Name: Bcl-2 homologous antagonist/killer Size: 211 amino acids; 23409 Da
Subunit: Interacts with BCL2A1 (By similarity). Homodimer. Formation of the homodimer is zinc-dependent. Formsheterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L). Interacts with myxoma virus protein M11L.Interacts with BOP/C22orf29
Subcellular location: Mitochondrion membrane; Single-pass membrane protein (Potential)
6/9 PDB 3D structures from  and Proteopedia  for BAK1 (see all 9):1BXL (3D)
2IMS (3D)
2IMT (3D)
2JBY (3D)
2JCN (3D)
2XPX (3D)
Secondary accessions: Q6I9T6 Q92533Explore the universe of human proteins at neXtProt for BAK1: NX_Q16611
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q16611
BAK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001179.1
ENSEMBL proteins: ENSP00000363591 ENSP00000353878 ENSP00000391258 Reactome Protein details: Q16611
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
BAK1 for ontologies About GeneDecksing
BAK1 Antibody Products:
Assay Products for BAK1: |
Protein
Domains /
Families
for BAK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BAK1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q16611ProtoNet protein and cluster: Q16611 1 Blocks protein family: IPB000712 Apoptosis regulator Bcl-2 protein
UniProtKB/Swiss-Prot: BAK_HUMAN, Q16611Domain: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for theirinteraction with anti-apoptotic members of the Bcl-2 familySimilarity: Belongs to the Bcl-2 family |
Function
for BAK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BAK_HUMAN, Q16611Function: In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizingthe anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ionsinhibit the promotion of apoptosis Genatlas biochemistry entry for BAK1:BCL2-antagonist/killer 1,BAX subfamily
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BAK1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BAK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BAK1 (NM_001188) | |  | Sino Biological Human cDNA Clone for BAK1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BAK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAK1 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
BAK1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for BAK1:
Animal Models:
Mouse knock-out Bak1tm1Thsn for BAK1
13 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Bak1):
BAK1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for BAK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | | | 2 | Apoptosis Modulation and Signaling | | | 3 | Apoptotic Pathways in Synovial Fibroblasts | | | 4 | Apoptosis and Autophagy | | | 5 | Integrated Breast Cancer Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for BAK1
1  R&D Systems Pathway for BAK1
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BAK1
1 
Cell Signaling Technology (CST) Pathway for BAK1
1  GeneGo (Thomson Reuters) Pathway for BAK1
5  BioSystems Pathways for BAK1
3 
Reactome Pathways for BAK1
1 
Kegg Pathway (Kegg details for BAK1):
BAK1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BAK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/46 Interacting proteins for BAK1 (Q166111, 2, 3 ENSP000003635914) via UniProtKB, MINT, STRING, and/or I2D (see all 46)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| BAX | Q078121, 2, 3, ENSP000002932884 | EBI-519866,EBI-516580 MINT-6740900 MINT-7306728 MINT-6740894 I2D:
score=5 STRING: ENSP00000293288 | | UBE3A | Q050862, 3, ENSP000003810454 | MINT-69611 MINT-69608 I2D:
score=1 STRING: ENSP00000381045 | | MFN1 | Q8IWA42, 3, ENSP000002639694 | MINT-8258771 I2D:
score=1 STRING: ENSP00000263969 | | DBN1 | Q166432, 3 | MINT-8249245 I2D:
score=2 | | MT-RNR2 | Q8IVG92, 3 | MINT-19416 I2D:
score=1 |
About this table
Gene Ontology (GO): 5/49 biological process terms (GO ID links to tree view) (see all 49): About this table
BAK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for BAK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
BAK1 for compounds About GeneDecksing
 Browse Tocris compounds for BAK1
10/53 Novoseek chemical compound relationships for BAK1 gene (see all 53) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| noxa |
81.6 |
9 |
18176116 (1), 17569614 (1), 18723481 (1), 17718901 (1) (see all 9) |
| phosphatidylserine |
54 |
1 |
19266285 (1) |
| bortezomib |
47.6 |
1 |
15767553 (1) |
| dutp |
45.9 |
1 |
12865785 (1) |
| perillyl alcohol |
41.7 |
6 |
12530055 (3), 9276644 (2) |
| etoposide |
39.8 |
4 |
9362454 (2), 18366759 (1), 16873896 (1) |
| sanguinarine |
35 |
2 |
16505117 (1), 17005319 (1) |
| gossypol |
34.3 |
1 |
15657349 (1) |
| camptothecin |
32 |
5 |
16794010 (2), 10692111 (1), 20223826 (1) |
| resveratrol |
31.6 |
6 |
16550006 (2), 12902349 (1), 17569614 (1), 17718901 (1) |
Search CenterWatch for drugs/clinical trials and news about BAK1 / BAK
|
Transcripts
for BAK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BAK1 gene: NM_001188.3 Unigene Cluster for BAK1: BCL2-antagonist/killer 1 Hs.485139 [show with all ESTs]Unigene Representative Sequence: CR6270203 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374467(uc003oer.3 uc003oes.3 uc003oet.3 uc010jvb.3 uc003oeu.3 uc011drj.1)
ENST00000360661 ENST00000442998
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BAK1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BAK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BAK1 (NM_001188) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BAK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAK1 |
Additional cDNA sequence: AK292093.1 AK293547.1 AK303422.1 BC004431.1 CR457419.1 CR627020.1 U16811.1 U23765.1 X84213.1 12 DOTS entries: DT.312432 DT.100853480 DT.101982299 DT.100810035 DT.95137351 DT.121304388 DT.100709501 DT.100810036 DT.121617957 DT.95137355 DT.97769031 DT.97846728 24/231 AceView cDNA sequences (see all 231): CR615881 AI197795 AL522403 BQ054099 BU849632 BM855203 BU848650 BE793110 CR615932 AU280497 BG696776 BQ963042 BX362974 BQ052127 AL536162 AL559269 CR608985 CA495326 BX385444 CF530051 BG752155 BI089592 CR600490 BU540950
GeneLoc Exon Structure
|
Expression
for BAK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BAK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCCTCACCT
About this image
See BAK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BAK1
SOURCE GeneReport for Unigene cluster: Hs.485139
UniProtKB/Swiss-Prot: BAK_HUMAN, Q16611Tissue specificity: Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle
SABiosciences Expression via Pathway-Focused PCR Arrays including BAK1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BAK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BAK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BAK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BAK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAK1 |
Orthologs
for BAK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BAK1 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for BAK1 (if available)
TreeFam Gene Tree for BAK1 (if available) |
Paralogs
for BAK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BAK1 gene
- BCL22 BCL2L22 BCL2L12 BAX2
2 SIMAP similar genes for BAK1 using alignment to 2 protein entries: BAK_HUMAN (see all proteins):DKFZp686D0345 BAK
BAK1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for BAK1
PGOHUM00000242541
|
Genomic Variants
for BAK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BAK1 (33540323 - 33548070 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BAK1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BAK1 |
|
Disorders
/ Diseases
for BAK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BAK1 for disorders About GeneDecksing
OMIM gene information: 600516
OMIM disorders: --
20/95  diseases for BAK1 (see all 95): About MalaCardsb-cell non-hodgkin lymphoma diffuse large b-cell lymphoma non-hodgkin lymphoma non-small cell lung carcinoma
b-cell lymphomas odontogenic myxoma abdominal aortic aneurysm benign mammary dysplasia
aortic aneurysm myxoma hodgkin's lymphoma keratoacanthoma
oral squamous cell carcinoma mantle cell lymphoma lymphocytic leukemia laryngitis
squamous cell carcinoma carcinoma female breast cancer subacute thyroiditis
1 disease from the University of Copenhagen DISEASES database for BAK1:Telangiectasis 10/61 Novoseek disease relationships for BAK1 gene (see all 61) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glaucoma absolute |
57.3 |
3 |
15638362 (2), 15510481 (1) |
| tumors |
49.8 |
75 |
10457328 (5), 17476972 (5), 8909234 (3), 16781827 (2) (see all 34) |
| cancer |
49 |
24 |
12120204 (3), 17047195 (2), 10706081 (2), 10969770 (2) (see all 15) |
| necrosis |
42 |
17 |
10488411 (2), 16528364 (1), 17047195 (1), 10491014 (1) (see all 12) |
| keratoacanthoma |
41.6 |
1 |
9415228 (1) |
| prostate cancer |
36.4 |
16 |
16794010 (4), 17062688 (3), 9815595 (1), 12479363 (1) (see all 8) |
| colon cancer |
33.2 |
3 |
15824729 (1), 16847458 (1), 10911913 (1) |
| nsclc |
28 |
10 |
17688235 (3), 16410245 (3), 10070896 (2), 14499626 (2) |
| lymphocytic leukemia chronic b-cell |
28 |
2 |
12176904 (2) |
| cancer lung |
27 |
12 |
18800351 (2), 19320642 (2), 19381065 (2), 10070896 (1) (see all 6) |
Human Genome Epidemiology (HuGE) Navigator: BAK1 (19 documents)
Export disorders for BAK1 gene to outside databases
|
Publications
for BAK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BAK1 gene, integrated from 9 sources (see all 611):
(articles sorted by number of sources associating them with BAK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. (PubMed id 7715731)1, 2, 3, 9 Kiefer M.C.... Barr P.J. (1995)
- Induction of apoptosis by the Bcl-2 homologue Bak. (PubMed id 7715730)1, 2, 3 Chittenden T.... Guild B.C. (1995)
- A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. (PubMed id 8521816)1, 2, 9 Chittenden T.... Lutz R.J. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. (PubMed id 9020082)1, 2 Sattler M.... Fesik S.W. (1997)
- Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. (PubMed id 7715729)1, 2 Farrow S.N.... Brown R. (1995)
- BAK overexpression mediates p53-independent apoptosis inducing effects on human gastric cancer cells. (PubMed id 15248898)1, 9 Tong Q.S....Qian W. (2004)
- Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak. (PubMed id 16794010)1, 9 Castilla C....Saez C. (2006)
- Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1. (PubMed id 16529740)1, 9 Ihrlund L.S....Shoshan M.C. (2006)
|
External Searches for BAK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BAK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BAK1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BAK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for BAK1 gene:
Search GeneIP for patents involving BAK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BAK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for BAK1 | | OriGene shRNA RFP for BAK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BAK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BAK1 | | | OriGene Protein Over-expression Lysate for BAK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BAK1 | | OriGene 3'-UTR Clone for BAK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BAK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BAK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BAK1 | | OriGene Custom Protein Services for BAK1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BAK1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BAK1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAK1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BAK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BAK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BAK1 |
| |
 |  |  |  | |
| | Antibodies & Assays for BAK1 |
| | | | Search Tocris compounds for BAK1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | BAK1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAK1 |
|  |  |  | | | | ThermoFisher Antibodies for BAK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAK1 |
|
|
|
|
