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Aliases for BAIAP3 Gene

Aliases for BAIAP3 Gene

  • BAI1 Associated Protein 3 2 3 5
  • BAI1-Associated Protein 3 2 3
  • BAP3 3 4
  • BAI-Associated Protein 3 3
  • KIAA0734 4

External Ids for BAIAP3 Gene

Previous GeneCards Identifiers for BAIAP3 Gene

  • GC16P001400
  • GC16P001324
  • GC16P001383

Summaries for BAIAP3 Gene

Entrez Gene Summary for BAIAP3 Gene

  • This p53-target gene encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. It interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. This protein also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for BAIAP3 Gene

BAIAP3 (BAI1 Associated Protein 3) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include protein C-terminus binding. An important paralog of this gene is UNC13D.

Gene Wiki entry for BAIAP3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAIAP3 Gene

Genomics for BAIAP3 Gene

Regulatory Elements for BAIAP3 Gene

Enhancers for BAIAP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F001331 1.3 FANTOM5 ENCODE 23.3 -1.6 -1551 2.1 ELF3 TBP HDAC1 PKNOX1 ARID4B BMI1 DNMT3B ZBTB40 ETS1 SCRT2 BAIAP3 UBE2I MAPK8IP3 UNKL SPSB3 EME2 RPS20P2
GH16F001296 1.4 Ensembl ENCODE 17.2 -34.4 -34418 5.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YY1 ZNF143 FOS KLF13 ZNF263 ENSG00000261505 ENSG00000260954 JMJD8 ENSG00000226890 BAIAP3 ENSG00000200059 PRSS29P ENSG00000261240 ZNF598 UBE2I
GH16F001350 1.1 ENCODE 14.5 +18.0 18010 2.4 ATF1 CREB3L1 MLX ARID4B SIN3A ETS1 YY1 ELK1 ZNF207 ZNF143 BAIAP3 JMJD8 TMEM204 TPSG1 ENSG00000260954 GNPTG LOC102724014
GH16F001291 1.1 FANTOM5 ENCODE 14.4 -42.4 -42410 0.4 SAP130 ARID4B YY1 E2F1 HIC1 SCRT2 NR2F6 ZNF687 NFIA L3MBTL2 BAIAP3 TPSD1 RPS20P2 GNPTG TSR3 UBE2I CACNA1H TPSP2 ENSG00000260710
GH16F001271 1.3 Ensembl ENCODE 11.9 -61.8 -61775 1.6 PKNOX1 FEZF1 ZNF2 ZNF302 ZNF416 SP3 REST ZNF592 ZNF610 ZNF585B HN1L ENSG00000261505 ENSG00000260051 ENSG00000260954 JMJD8 RHOT2 SNORA64 ENSG00000255513 LOC105371038 IFT140
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BAIAP3 on UCSC Golden Path with GeneCards custom track

Promoters for BAIAP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001798934 99 1001 PHF8 ZBTB2 HINFP MTA2 RNF2 ZBTB7A OSR2 ZFHX2 GLIS2 ZNF692

Genomic Location for BAIAP3 Gene

Chromosome:
16
Start:
1,333,601 bp from pter
End:
1,349,441 bp from pter
Size:
15,841 bases
Orientation:
Plus strand

Genomic View for BAIAP3 Gene

Genes around BAIAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAIAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAIAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAIAP3 Gene

Proteins for BAIAP3 Gene

  • Protein details for BAIAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94812-BAIP3_HUMAN
    Recommended name:
    BAI1-associated protein 3
    Protein Accession:
    O94812
    Secondary Accessions:
    • A2A2B2
    • B2RCD7
    • B4DGS5
    • B4DIK3
    • B4DRK9
    • B4DRP1
    • E7EUB9
    • H3BUH8
    • H3BVI3
    • H7C2Q1
    • O94839
    • Q2M226
    • Q658J2
    • Q76N05
    • Q96RZ3
    • Q9UJK1

    Protein attributes for BAIAP3 Gene

    Size:
    1187 amino acids
    Molecular mass:
    131901 Da
    Quaternary structure:
    • Interacts with BAI1.
    SequenceCaution:
    • Sequence=BAA34454.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG57886.1; Type=Erroneous termination; Positions=717; Note=Translated as Gly.; Evidence={ECO:0000305};

    Alternative splice isoforms for BAIAP3 Gene

neXtProt entry for BAIAP3 Gene

Post-translational modifications for BAIAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BAIAP3 Gene

Domains & Families for BAIAP3 Gene

Gene Families for BAIAP3 Gene

Suggested Antigen Peptide Sequences for BAIAP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94812

UniProtKB/Swiss-Prot:

BAIP3_HUMAN :
  • Contains 2 C2 domains.
Domain:
  • Contains 2 C2 domains.
  • Contains 1 MHD1 (MUNC13 homology domain 1) domain.
  • Contains 1 MHD2 (MUNC13 homology domain 2) domain.
genes like me logo Genes that share domains with BAIAP3: view

Function for BAIAP3 Gene

Molecular function for BAIAP3 Gene

GENATLAS Biochemistry:
brain-specific angiogenesis inhibitor (BAI1)-associated protein 3,predominantly expressed in brain,homolog to synaptotagmin,potentially regulating the release of neurotransmitters

Gene Ontology (GO) - Molecular Function for BAIAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008022 protein C-terminus binding TAS 9790924
genes like me logo Genes that share ontologies with BAIAP3: view
genes like me logo Genes that share phenotypes with BAIAP3: view

Animal Models for BAIAP3 Gene

MGI Knock Outs for BAIAP3:

Animal Model Products

miRNA for BAIAP3 Gene

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BAIAP3 Gene

Localization for BAIAP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BAIAP3 gene
Compartment Confidence
endoplasmic reticulum 3
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for BAIAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098793 presynapse IEA --
genes like me logo Genes that share ontologies with BAIAP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BAIAP3 Gene

Pathways & Interactions for BAIAP3 Gene

genes like me logo Genes that share pathways with BAIAP3: view

Pathways by source for BAIAP3 Gene

1 KEGG pathway for BAIAP3 Gene

Interacting Proteins for BAIAP3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000324510%0d%0a9606.ENSP00000313046%0d%0a
Selected Interacting proteins: O94812-BAIP3_HUMAN ENSP00000324510 for BAIAP3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for BAIAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IPI 9790924
GO:0007269 neurotransmitter secretion TAS 9790924
genes like me logo Genes that share ontologies with BAIAP3: view

No data available for SIGNOR curated interactions for BAIAP3 Gene

Transcripts for BAIAP3 Gene

Unigene Clusters for BAIAP3 Gene

BAI1-associated protein 3:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAIAP3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12: - -
SP13: -
SP14: - -
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: - -
SP23:
SP24: -

ExUns: 15a · 15b · 15c · 15d ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

ExUns: 28a · 28b · 28c ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33a · 33b ^ 34
SP1:
SP2: -
SP3:
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: - - -
SP24:

Relevant External Links for BAIAP3 Gene

GeneLoc Exon Structure for
BAIAP3
ECgene alternative splicing isoforms for
BAIAP3

Expression for BAIAP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BAIAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BAIAP3 Gene

This gene is overexpressed in Pituitary (x22.4) and Brain - Hypothalamus (x5.6).

Protein differential expression in normal tissues from HIPED for BAIAP3 Gene

This gene is overexpressed in Frontal cortex (26.3), Liver (21.1), Brain (12.2), and Peripheral blood mononuclear cells (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BAIAP3 Gene



Protein tissue co-expression partners for BAIAP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of BAIAP3 Gene:

BAIAP3

SOURCE GeneReport for Unigene cluster for BAIAP3 Gene:

Hs.458427

mRNA Expression by UniProt/SwissProt for BAIAP3 Gene:

O94812-BAIP3_HUMAN
Tissue specificity: Predominantly expressed in brain.
genes like me logo Genes that share expression patterns with BAIAP3: view

Primer Products

Orthologs for BAIAP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAIAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAIAP3 34 35
  • 97.7 (n)
cow
(Bos Taurus)
Mammalia BAIAP3 34 35
  • 86.42 (n)
dog
(Canis familiaris)
Mammalia BAIAP3 34 35
  • 85.25 (n)
mouse
(Mus musculus)
Mammalia Baiap3 34 16 35
  • 85.12 (n)
oppossum
(Monodelphis domestica)
Mammalia BAIAP3 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAIAP3 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia baiap3 34
  • 58.68 (n)
Str.19005 34
zebrafish
(Danio rerio)
Actinopterygii baiap3 34 35
  • 57.73 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005816 34
  • 50.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta unc-13-4A 36 34 35
  • 48.41 (n)
CG11819 36
  • 22 (a)
CG34349 35
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F54G2.1 36 34 35
  • 43.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for BAIAP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BAIAP3 Gene

ENSEMBL:
Gene Tree for BAIAP3 (if available)
TreeFam:
Gene Tree for BAIAP3 (if available)

Paralogs for BAIAP3 Gene

Paralogs for BAIAP3 Gene

(1) SIMAP similar genes for BAIAP3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with BAIAP3: view

Variants for BAIAP3 Gene

Sequence variations from dbSNP and Humsavar for BAIAP3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs796052185 Likely benign 1,346,605(+) CGCAG(C/G)CCGTG reference, missense
rs10903006 -- 1,331,706(+) ACTCA(A/G)CCTAT upstream-variant-2KB
rs111164744 -- 1,340,004(+) GCACA(C/G)GCACA intron-variant
rs111164745 -- 1,340,187(+) CACAC(A/G)GACAC intron-variant
rs111173893 -- 1,340,132(+) GCACA(C/G)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAIAP3 Gene

Variant ID Type Subtype PubMed ID
nsv974746 CNV duplication 23825009
nsv952899 CNV deletion 24416366
nsv471066 CNV loss 18288195
nsv428316 CNV gain+loss 18775914
nsv1148565 CNV insertion 26484159
nsv1138405 CNV deletion 24896259
nsv1125107 CNV deletion 24896259
nsv1117153 CNV tandem duplication 24896259
nsv1046314 CNV loss 25217958
esv3637613 CNV loss 21293372
esv2762143 CNV gain 21179565
esv2750326 CNV deletion 23290073
esv2750325 CNV deletion 23290073
esv2422427 CNV duplication 17116639
dgv2692n100 CNV gain 25217958
dgv1483e59 CNV duplication 20981092

Variation tolerance for BAIAP3 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.32; 70.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BAIAP3 Gene

Human Gene Mutation Database (HGMD)
BAIAP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BAIAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAIAP3 Gene

Disorders for BAIAP3 Gene

Relevant External Links for BAIAP3

Genetic Association Database (GAD)
BAIAP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BAIAP3

No disorders were found for BAIAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BAIAP3 Gene

Publications for BAIAP3 Gene

  1. Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1. (PMID: 9790924) Shiratsuchi T. … Nakamura Y. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64
  5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4 64

Products for BAIAP3 Gene

Sources for BAIAP3 Gene

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