V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

BAIAP3 Gene

protein-coding   GIFtS: 57

GC16P001324
BAI1-associated protein 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
BAP3 1, 2, 3, 5
KIAA0734 1, 2, 3
MGC138334 2
Descriptions
BAI-associated protein 3 2
BAI1-associated protein 3 2
External Ids
HGNC: 9481
Entrez Gene: 89382
UniProtKB: O948123
Ensembl: ENSG000000075167
Search outside databases for aliases for BAIAP3 gene

Previous GC identifer: GC16P001400

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BAIAP3:
This p53-target gene encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span
transmembrane protein and a member of the secretin receptor family. It interacts with the
cytoplasmic region of brain-specific angiogenesis inhibitor 1. This protein also contains two C2
domains, which are often found in proteins involved in signal transduction or membrane
trafficking. Its expression pattern and similarity to other proteins suggest that it may be
involved in synaptic functions. [provided by RefSeq]

Gene Wiki entry for BAIAP3
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BAIAP3 gene  

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

BAIAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P001324:     (about GC identifiers)

Start:
1,323,655 bp from pter
End:
1,339,443 bp from pter
Size:
15,789 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000016.8  NT_037887.4  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BAIP3_HUMAN, O94812 (See protein sequence)
Recommended Name: BAI1-associated protein 3  
Size: 1187 amino acids; 131901 Da
Subunit: Interacts with BAI1
Secondary accessions: B2RCD7 O94839 Q2M226 Q658J2 Q76N05 Q96RZ3 Q9UJK1
Alternative splicing: 2 isoforms:  O94812-1   O94812-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_003924.2  

    ENSEMBL proteins: 
    ENSP00000380625 ENSP00000380626 ENSP00000324510 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (BAIAP3)
    Human Recombinant Proteins from Abnova (BAIAP3)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for BAIAP3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for BAIAP3
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (BAIAP3), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (BAIAP3)
    Search Novus for antibodies for BAIAP3

    Assays for BAIAP3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR014772 Munc13_dom-2
     IPR010439 DUF1041
     IPR019558 Munc13_subgr_dom-2
     IPR014770 Munc13_1
     IPR018029 C2_membr_targeting


       GeneDecks  BAIAP3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O94812

    ProtoNet protein and cluster: O94812

    2 Blocks protein families:
    IPB000008 C2 domain
    IPB010439 Protein of unknown function DUF1041


    UniProtKB/Swiss-Prot: BAIP3_HUMAN, O94812
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 MHD1 (MUNC13 homology domain 1) domain
    Similarity: Contains 1 MHD2 (MUNC13 homology domain 2) domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BAIAP3)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003933

                  Applied Biosystems Silencer® siRNAs for BAIAP3

                  Sigma-Aldrich siRNA for BAIAP3  
                         Sigma-Aldrich shRNA for BAIAP3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003933
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003933
                                     untagged cDNA clone in CMV expression vector: NM_003933 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003933

    Genatlas biochemistry entry for BAIAP3:
    brain-specific angiogenesis inhibitor (BAI1)-associated protein 3,predominantly expressed in
    brain,homolog to synaptotagmin,potentially regulating the release of neurotransmitters

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008022 protein C-terminus binding TAS9790924
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  BAIAP3 


    5 Interacting proteins for BAIAP3 (ENSP000003245103 O948121) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAI1O145141STRING (score=.927) EBI-1995203, EBI-1995178
    FYNENSP000003576563STRING (score=.899)
    MAPK14ENSP000002297943STRING (score=.899)
    SCTRENSP000000191033STRING (score=.784)
    --ENSP000003707953STRING (score=.899)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007269 neurotransmitter secretion TAS9790924
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for BAIAP3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BAIAP3)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003933

                  Sigma-Aldrich siRNA for BAIAP3  
                         Sigma-Aldrich shRNA for BAIAP3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_003933  

    REFSEQ mRNAs for BAIAP3 gene: 

    NM_003933.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_003933  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003933
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003933
                                     untagged cDNA clone in CMV expression vector: NM_003933 

    Additional cDNA sequence: 

    AB018277.2 AF038191.1 AK294491.1 AK294576.1 AK294744.1 AK295645.1 AK299309.1 AK299358.1 
    AK315059.1 AL834321.1 BC104966.1 BC112129.1 

    10 DOTS entries:

    DT.75118306  DT.100815748  DT.100815756  DT.95161516  DT.92435001  DT.120662077  DT.120662127  DT.449556 
    DT.92434995  DT.91706459 

    24/87 AceView cDNA sequences (see all 87 ):

    AB018277 CB148214 AI564977 BF448577 BI771405 NM_003933 BM981388 BP348862 
    AI696810 CB153038 BM827931 CD106045 CB155761 CD251629 BQ425972 BQ277755 
    F13300 BI831797 BG707986 BU948670 BE869971 BI914498 BI755009 AL041517 

    highest scoring ESTs for BAIAP3:

    AB018277 AA078749 AA079823 AA682952 AA782001 AI358964 AI537389 AI564977 AI696810 AI816746 

    Unigene Cluster for BAIAP3:

    BAI1-associated protein 3
    Hs.458427  [show with all ESTs]
    Unigene Representative Sequence: AL834321


    GeneLoc Exon Structure

    5/24 Alternative Splicing Database (ASD) splice patterns (SP) for BAIAP3 (see all 24 )

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 15a · 15b · 15c · 15d ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b ^
    SP1:                                            -                                                                                                               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 28a · 28b · 28c ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33a · 33b ^ 34
    SP1:                                                                  
    SP2:  -                                                               
    SP3:                                                                  
    SP4:  -     -                                                         
    SP5:  -                                                               

    About this scheme

    ECgene alternative splicing isoforms for BAIAP3

    3 Ensembl transcripts including schematic representations:
    ENST00000397488  ENST00000397489  ENST00000324385  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    BAIAP3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for BAIAP3

    1 / 2 / 3

    5 probe-sets matching BAIAP3 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    41115_s_at2, 3 U95-A 2 0.62 0.91 1.00 1.00 AB018277 1.00 1.00 1.00 1

    216356_x_at2, 3 U133-A 1 1.00 1.00 -- -- AB018277 1.00 1.00 1.00 1

    204874_x_at2, 3 U133-A 1 0.73 1.00 -- -- NM_003933 0.60 1.00 0.82 1

    216356_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    204874_x_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    GeneDecks  BAIAP3 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.458427

    Expression variation in blood from EXPOLDB for BAIAP3

    UniProtKB/Swiss-Prot: BAIP3_HUMAN, O94812
    Tissue specificity: Predominantly expressed in brain

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for BAIAP3 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    BAIAP31   -- BAI1-associated protein 3 83.5(n)
    83.78(a)
    490079  XM_547199.2  XP_547199.2 
    chimpanzee
    (Pan troglodytes)
    BAIAP31   -- BAI1-associated protein 3 97.7(n)
    97.64(a)
    749977  XM_001172572.1  XP_001172572.1 
    cow
    (Bos taurus)
    BAIAP31   -- BAI1-associated protein 3 86.33(n)
    88.86(a)
    531686  XM_610186.3  XP_610186.3 
    rat
    (Rattus norvegicus)
    LOC6852971   -- similar to BAI1-associated protein 3 (BAP3) 84.86(n)
    89.38(a)
    685297  XM_001061609.1  XP_001061609.1 
    mouse
    (Mus musculus)
    Baiap35 17 BAI1-associated protein 3   -- BC158116 
    About this table        Species with no ortholog for BAIAP3

    ENSEMBL Gene Tree for BAIAP3
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for BAIAP3 gene
    UNC13D2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/114 NCBI SNPs in BAIAP3 are shown (see all 114 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 71)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs11323561,2
    C,F,H1334508(+) GAATGC/ACAAGA 1 A/D mis14Minor allele frequency- A:0.04EU EA WA 420
    rs121033121,2
    F,H1338603(+) GTGACG/ATGTGT 1 -- ut31 ese34Minor allele frequency- A:0.07EU EA WA 418
    rs360745091,2
    C,F1336481(-) AGAGAC/ATGATG 1 I/S mis11Minor allele frequency- A:0.03NA 76
    --
    rs49848121,2
    C1323912(+) CGACGC/TCCCCT 1 -- ng510--------
    --
    rs71856351,2
    A1323328(+) TCCCTA/GGGGTC 1 -- ng510--------
    rs49848131,2
    A1324221(+) CCTTTA/GGTCCC 1 -- ng510--------
    rs116421181,2
    C1328619(+) CCGCCA/GCAGGA 1 R/H mis1 ese30--------
    rs11323581,2
    C,F,H1337816(+) CTGGAC/TGCCAA 1 D/D syn19Minor allele frequency- T:0.29EU EA WA NA 802
    rs118666351,2
    C,F1331133(+) CAGGCC/TCCCAC 1 A/A syn1 ese31Minor allele frequency- T:0.14NA 76
    rs22356311,2
    F,H1332237(+) CCCACC/TGAGGA 1 T/T syn1 ese35Minor allele frequency- T:0.03EA EU WA 1884
    About this table

    HapMap Linkage Disequilibrium images for BAIAP3 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 604009

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/15 PubMed articles for BAIAP3 gene (see all 15 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 8938 HGNC: 948 AceView: BAIAP3 Ensembl:ENSG00000007516 euGenes: HUgn8938
    ECgene: BAIAP3 H-InvDB: BAIAP3
    (According to HUGE)
    About This Section

    HUGE: KIAA0734
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for BAIAP3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for BAIAP3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for BAIAP3 Antibodies for BAIAP3
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for BAIAP3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (BAIAP3)
     Antibodies (BAIAP3)
     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (BAIAP3)
     Antibodies (BAIAP3)
     Search OriGene for BAIAP3
     Search Tocris compounds for BAIAP3




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for BAIAP3

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    BAIAP3 Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com