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BAIAP2L2 Gene

protein-coding   GIFtS: 44

GC22M036806
BAI1-associated protein 2-like 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ22582 1, 2
OTTHUMP00000028513 2
Descriptions
BAI1-associated protein 2-like 2 2
BAI1-associated protein 2-like protein 2 3
External Ids
HGNC: 262031
Entrez Gene: 801152
UniProtKB: Q6UXY13
Ensembl: ENSG000001282987
Search outside databases for aliases for BAIAP2L2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: BI2L2_HUMAN, Q6UXY1
Function: May function as an adapter protein (Potential)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BAIAP2L2 gene  

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

BAIAP2L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M036806:     (about GC identifiers)

Start:
36,810,842 bp from pter
End:
36,836,622 bp from pter
Size:
25,781 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000022.9  NT_011520.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BI2L2_HUMAN, Q6UXY1 (See protein sequence)
Recommended Name: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2  
Size: 529 amino acids; 58987 Da
Secondary accessions: Q96BG7
Alternative splicing: 2 isoforms:  Q6UXY1-1   Q6UXY1-2   

REFSEQ proteins: NP_079321.3  

ENSEMBL proteins: 
ENSP00000384877 ENSP00000328876 ENSP00000371085 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (BAIAP2L2)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IDA18029348
GO:0005737 cytoplasm IDA18029348
GO:0005739 mitochondrion IDA18029348
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Antibodies for BAIAP2L2: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for BAIAP2L2
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for BAIAP2L2

Assays for BAIAP2L2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro domains/families:
 IPR011511 SH3_2
 IPR001452 SH3_domain
 IPR013606 IRSp53/MIM_homology_IMD


   GeneDecks  BAIAP2L2 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q6UXY1

ProtoNet protein and cluster: Q6UXY1

3 Blocks protein families:
IPB001452 SH3 domain signature
IPB011511 Variant SH3
IPB013606 IRSp53/MIM homology domain


UniProtKB/Swiss-Prot: BI2L2_HUMAN, Q6UXY1
Domain: The IMD domain is predicted to have a helical structure. It may induce actin bundling and
filopodia formation (By similarity)
Similarity: Contains 1 IMD (IRSp53/MIM homology) domain
Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (BAIAP2L2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025045

              Applied Biosystems Silencer® siRNAs for BAIAP2L2

              Sigma-Aldrich siRNA for BAIAP2L2  
                     Sigma-Aldrich shRNA for BAIAP2L2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for BAIAP2L2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_025045
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_025045
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_025045 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_025045

UniProtKB/Swiss-Prot: BI2L2_HUMAN, Q6UXY1
Function: May function as an adapter protein (Potential)

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008093 cytoskeletal adaptor activity IEA--
GO:0017124 SH3 domain binding IEA--
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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007165 signal transduction IEA--
GO:0046847 filopodium formation IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BAIAP2L2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (BAIAP2L2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025045

              Sigma-Aldrich siRNA for BAIAP2L2  
                     Sigma-Aldrich shRNA for BAIAP2L2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_025045  

REFSEQ mRNAs for BAIAP2L2 gene: 

NM_025045.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_025045  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_025045
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_025045
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_025045 

Additional cDNA sequence: 

AK026263.1 AY358164.1 BC015619.2 

6 DOTS entries:

DT.95158759  DT.410083  DT.97789625  DT.97837824  DT.97785799  DT.91881002 

24/46 AceView cDNA sequences (see all 46 ):

BM790083 AK026263 AY358164 AI732208 BM128573 BG576439 BI759003 AA974880 
AW661906 BQ948702 BM018178 BM050416 BU185166 BI819818 CK819409 AA570148 
BG030320 BX281686 AI679197 BI861483 BM793696 AI990949 NM_025045 BU740974 

highest scoring ESTs for BAIAP2L2:

AI732208 AY358164 BC015619 BG750736 BI759003 BM050416 BQ948702 BU185166 BX281686 AA502007 

Unigene Cluster for BAIAP2L2:

BAI1-associated protein 2-like 2
Hs.474822  [show with all ESTs]
Unigene Representative Sequence: NM_025045


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for BAIAP2L2

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1:                                                                                          
SP2:                                                                          -               
SP3:                                                                                          
SP4:                                                                                          

About this scheme

ECgene alternative splicing isoforms for BAIAP2L2

3 Ensembl transcripts including schematic representations:
ENST00000402500  ENST00000332536  ENST00000381669  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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BAIAP2L2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for BAIAP2L2

1 / 2 / 3

6 probe-sets matching BAIAP2L2 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
74042_g_at2, 3 U95-E 1 1.00 1.00 0.95 0.95 AI732208 0.80 1.00 0.91 1
74040_at2, 3 U95-E 1 1.00 1.00 0.91 1.06 AI732208 0.80 1.00 0.91 1

221178_at2, 3 U133-A 1 1.00 1.00 -- -- NM_025045 0.60 1.00 0.82 1

228876_at2, 3 U133-B 1 1.00 1.00 -- -- AA532851 0.40 1.00 0.76 1

221178_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

228876_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  BAIAP2L2 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CCCTCTCTGT

SOURCE GeneReport for Unigene cluster: Hs.474822
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for BAIAP2L2 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
BAIAP2L21   -- BAI1-associated protein 2-like 2 78.22(n)
79.8(a)
610178  XM_847607.1  XP_852700.1 
chimpanzee
(Pan troglodytes)
BAIAP2L21   -- BAI1-associated protein 2-like 2 98.99(n)
99.05(a)
743623  XM_001147630.1  XP_001147630.1 
rat
(Rattus norvegicus)
Baiap2l21   -- BAI1-associated protein 2-like 2 84.37(n)
88.28(a)
685357  XM_001063469.1  XP_001063469.1 
mouse
(Mus musculus)
Baiap2l21, 5 155
BAI1-associated protein 2-like 21, 5 89.12(n)1
92.71(a)1
2074951  NM_177580.31  NP_808248.11 
 AK1437835  BC0489375 
chicken
(Gallus gallus)
BAIAP2L21   -- BAI1-associated protein 2-like 2 69.57(n)
65.63(a)
418029  XM_416266.2  XP_416266.1 
About this table        Species with no ortholog for BAIAP2L2

ENSEMBL Gene Tree for BAIAP2L2
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for BAIAP2L2 gene
BAIAP22  BAIAP2L12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/200 NCBI SNPs in BAIAP2L2 are shown (see all 200 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 56)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 22 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs96227261,2
A,C,F,H36836634(+) AGGAGT/CGGCAG 1 -- ng315Minor allele frequency- C:0.27NS EU EA WA 580
rs119129701,2
C36811154(+) GGACCC/TGCTTC 1 -- ut310--------
rs37471681,2
C,F,H36813193(+) TTCACG/ATACGC 1 Y/Y syn1 ese36Minor allele frequency- A:0.04EA EU WA 1888
rs37471671,2
C,F,H36812372(+) TCATCG/AAGGCT 1 L/L syn13Minor allele frequency- A:0.03EA EU WA 1722
rs24134951,2
A,C,F,H36822829(+) CAAAGG/AAAGAA 1 -- int1 trp34Minor allele frequency- A:0.05EU EA WA 418
rs48217381,2
A,C,F,H36830426(+) acccgG/Taggtt 1 -- int14Minor allele frequency- T:0.39EU EA WA 416
rs42965271,2
A,C,F,H36832873(+) TGCGGC/TGCTCC 1 -- int13Minor allele frequency- T:0.35EA WA 298
rs1329291,2
A,C,F,H36816948(+) AACCCG/AAAGGC 1 -- int18Minor allele frequency- A:0.34EU EA WA 836
rs60010071,2
A,C,F,H36834619(+) TTGCAC/TGGGGA 1 -- int17Minor allele frequency- T:0.01EU EA WA NA 552
rs48217371,2
A,C,F,H36830328(+) gcatcC/Atcagc 1 -- int14Minor allele frequency- A:0.39EU EA WA 418
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HapMap Linkage Disequilibrium images for BAIAP2L2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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5 PubMed articles for BAIAP2L2 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 80115 HGNC: 26203 AceView: FLJ22582 Ensembl:ENSG00000128298 euGenes: HUgn80115
ECgene: BAIAP2L2 H-InvDB: BAIAP2L2
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for BAIAP2L2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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 Predesigned and custom siRNAs for BAIAP2L2 Antibodies for BAIAP2L2
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for BAIAP2L2 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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