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Aliases for BAIAP2L2 Gene

Aliases for BAIAP2L2 Gene

  • BAI1 Associated Protein 2 Like 2 2 3 5
  • Planar Intestinal- And Kidney-Specific BAR Domain Protein 2 3 4
  • BAI1-Associated Protein 2-Like Protein 2 3 4
  • Pinkbar 3 4
  • Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2-Like Protein 2 3
  • BAI1-Associated Protein 2-Like 2 2

External Ids for BAIAP2L2 Gene

Previous GeneCards Identifiers for BAIAP2L2 Gene

  • GC22M036806
  • GC22M038480
  • GC22M021445
  • GC22M038394
  • GC22M038517
  • GC22M038828

Summaries for BAIAP2L2 Gene

Entrez Gene Summary for BAIAP2L2 Gene

  • The protein encoded by this gene binds phosphoinositides and promotes the formation of planar or curved membrane structures. The encoded protein is found in RAB13-positive vesicles and at intercellular contacts with the plasma membrane. [provided by RefSeq, Dec 2012]

GeneCards Summary for BAIAP2L2 Gene

BAIAP2L2 (BAI1 Associated Protein 2 Like 2) is a Protein Coding gene. GO annotations related to this gene include SH3 domain binding and cytoskeletal adaptor activity. An important paralog of this gene is BAIAP2.

UniProtKB/Swiss-Prot for BAIAP2L2 Gene

  • Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAIAP2L2 Gene

Genomics for BAIAP2L2 Gene

Regulatory Elements for BAIAP2L2 Gene

Enhancers for BAIAP2L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around BAIAP2L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BAIAP2L2 Gene

Chromosome:
22
Start:
38,084,883 bp from pter
End:
38,111,304 bp from pter
Size:
26,422 bases
Orientation:
Minus strand

Genomic View for BAIAP2L2 Gene

Genes around BAIAP2L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAIAP2L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAIAP2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAIAP2L2 Gene

Proteins for BAIAP2L2 Gene

  • Protein details for BAIAP2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXY1-BI2L2_HUMAN
    Recommended name:
    Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
    Protein Accession:
    Q6UXY1
    Secondary Accessions:
    • B0QYE2
    • Q96BG7

    Protein attributes for BAIAP2L2 Gene

    Size:
    529 amino acids
    Molecular mass:
    58987 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BAIAP2L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAIAP2L2 Gene

Post-translational modifications for BAIAP2L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BAIAP2L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BAIAP2L2 Gene

Domains & Families for BAIAP2L2 Gene

Gene Families for BAIAP2L2 Gene

Suggested Antigen Peptide Sequences for BAIAP2L2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UXY1

UniProtKB/Swiss-Prot:

BI2L2_HUMAN :
  • The IMD domain consisting of an antiparallel dimer of three-helix bundles, featuring on one side a positively charged. The N-terminal alpha-helix inserts into the lipid bilayer. Also forms homodimers and homooligomers. The residue Trp-141 is essential for oligomer formation (By similarity).
Domain:
  • The IMD domain consisting of an antiparallel dimer of three-helix bundles, featuring on one side a positively charged. The N-terminal alpha-helix inserts into the lipid bilayer. Also forms homodimers and homooligomers. The residue Trp-141 is essential for oligomer formation (By similarity).
  • Contains 1 IMD (IRSp53/MIM homology) domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with BAIAP2L2: view

Function for BAIAP2L2 Gene

Molecular function for BAIAP2L2 Gene

UniProtKB/Swiss-Prot Function:
Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity).

Gene Ontology (GO) - Molecular Function for BAIAP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005543 phospholipid binding ISS --
GO:0008093 cytoskeletal adaptor activity IBA --
genes like me logo Genes that share ontologies with BAIAP2L2: view
genes like me logo Genes that share phenotypes with BAIAP2L2: view

Animal Models for BAIAP2L2 Gene

MGI Knock Outs for BAIAP2L2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for BAIAP2L2 Gene

Localization for BAIAP2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAIAP2L2 Gene

Cell membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane. Note=Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAIAP2L2 Gene COMPARTMENTS Subcellular localization image for BAIAP2L2 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for BAIAP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0005886 plasma membrane IEA --
GO:0012506 vesicle membrane IDA 21743456
GO:0015629 actin cytoskeleton IBA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with BAIAP2L2: view

Pathways & Interactions for BAIAP2L2 Gene

SuperPathways for BAIAP2L2 Gene

No Data Available

Interacting Proteins for BAIAP2L2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371085%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000302967%0d%0a
Selected Interacting proteins: ENSP00000371085 Q6UXY1-BI2L2_HUMAN for BAIAP2L2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for BAIAP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007009 plasma membrane organization IEA --
GO:0008286 insulin receptor signaling pathway IBA --
GO:0030838 positive regulation of actin filament polymerization IBA --
GO:0051017 actin filament bundle assembly IBA --
GO:0051764 actin crosslink formation IBA --
genes like me logo Genes that share ontologies with BAIAP2L2: view

No data available for Pathways by source and SIGNOR curated interactions for BAIAP2L2 Gene

Drugs & Compounds for BAIAP2L2 Gene

No Compound Related Data Available

Transcripts for BAIAP2L2 Gene

Unigene Clusters for BAIAP2L2 Gene

BAI1-associated protein 2-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAIAP2L2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for BAIAP2L2 Gene

GeneLoc Exon Structure for
BAIAP2L2
ECgene alternative splicing isoforms for
BAIAP2L2

Expression for BAIAP2L2 Gene

mRNA expression in normal human tissues for BAIAP2L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BAIAP2L2 Gene

This gene is overexpressed in Colon - Transverse (x10.9), Small Intestine - Terminal Ileum (x10.2), and Kidney - Cortex (x8.7).

Protein differential expression in normal tissues from HIPED for BAIAP2L2 Gene

This gene is overexpressed in Heart (46.3) and Adipocyte (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BAIAP2L2 Gene



Protein tissue co-expression partners for BAIAP2L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of BAIAP2L2 Gene:

BAIAP2L2

SOURCE GeneReport for Unigene cluster for BAIAP2L2 Gene:

Hs.474822

mRNA Expression by UniProt/SwissProt for BAIAP2L2 Gene:

Q6UXY1-BI2L2_HUMAN
Tissue specificity: Expressed in the epithelial layer of the intestine (at protein level).
genes like me logo Genes that share expression patterns with BAIAP2L2: view

Primer Products

Orthologs for BAIAP2L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAIAP2L2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia BAIAP2L2 34
  • 89.15 (n)
  • 91.16 (a)
BAIAP2L2 35
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Baiap2l2 34
  • 88.61 (n)
  • 92.13 (a)
Baiap2l2 16
Baiap2l2 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BAIAP2L2 34
  • 99.05 (n)
  • 99.05 (a)
BAIAP2L2 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Baiap2l2 34
  • 86.47 (n)
  • 89.42 (a)
cow
(Bos Taurus)
Mammalia BAIAP2L2 35
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BAIAP2L2 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAIAP2L2 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves BAIAP2L2 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BAIAP2L2 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia baiap2l2 34
  • 59.19 (n)
  • 57.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19687 34
zebrafish
(Danio rerio)
Actinopterygii baiap2l2 34
  • 52.09 (n)
  • 48.91 (a)
baiap2l2 35
  • 35 (a)
OneToMany
BAIAP2L2 (1 of 2) 35
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32082 35
  • 11 (a)
OneToMany
Species where no ortholog for BAIAP2L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAIAP2L2 Gene

ENSEMBL:
Gene Tree for BAIAP2L2 (if available)
TreeFam:
Gene Tree for BAIAP2L2 (if available)

Paralogs for BAIAP2L2 Gene

Paralogs for BAIAP2L2 Gene

(2) SIMAP similar genes for BAIAP2L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BAIAP2L2: view

Variants for BAIAP2L2 Gene

Sequence variations from dbSNP and Humsavar for BAIAP2L2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs738316 -- 38,102,978(+) gaggc(A/G)gagct intron-variant
rs5995535 -- 38,101,712(+) AGCCG(A/G)GCATG intron-variant
rs5995536 -- 38,104,820(+) AGAGT(A/G)AAACC intron-variant
rs6000994 -- 38,091,708(+) TTTTT(A/G)TATAG intron-variant
rs6000996 -- 38,095,758(+) AGTTG(G/T)CATTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BAIAP2L2 Gene

Variant ID Type Subtype PubMed ID
esv1386806 CNV insertion 17803354
esv2724223 CNV deletion 23290073
esv3345707 CNV duplication 20981092
esv996111 CNV insertion 20482838
nsv3623 CNV insertion 18451855
nsv471198 CNV loss 18288195
nsv508732 CNV insertion 20534489
nsv513591 CNV insertion 21212237
nsv589008 CNV loss 21841781
nsv829205 CNV loss 20364138
nsv829206 CNV gain 20364138
nsv834193 CNV loss 17160897
nsv834194 CNV loss 17160897

Variation tolerance for BAIAP2L2 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.92; 98.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BAIAP2L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BAIAP2L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAIAP2L2 Gene

Disorders for BAIAP2L2 Gene

Relevant External Links for BAIAP2L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BAIAP2L2

No disorders were found for BAIAP2L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BAIAP2L2 Gene

Publications for BAIAP2L2 Gene

  1. Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. (PMID: 21743456) Pykalainen A. … Lappalainen P. (Nat. Struct. Mol. Biol. 2011) 2 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 65
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 65
  5. Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis. (PMID: 21401524) Veltman D.M. … Insall R.H. (Biochem. J. 2011) 3 65

Products for BAIAP2L2 Gene

Sources for BAIAP2L2 Gene

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