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Aliases for BAIAP2L2 Gene

Aliases for BAIAP2L2 Gene

  • BAI1-Associated Protein 2-Like 2 2 3
  • Planar Intestinal- And Kidney-Specific BAR Domain Protein 3 4
  • BAI1-Associated Protein 2-Like Protein 2 3 4
  • Pinkbar 3 4
  • Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2-Like Protein 2 3

External Ids for BAIAP2L2 Gene

Previous GeneCards Identifiers for BAIAP2L2 Gene

  • GC22M036806
  • GC22M038480
  • GC22M021445

Summaries for BAIAP2L2 Gene

Entrez Gene Summary for BAIAP2L2 Gene

  • The protein encoded by this gene binds phosphoinositides and promotes the formation of planar or curved membrane structures. The encoded protein is found in RAB13-positive vesicles and at intercellular contacts with the plasma membrane. [provided by RefSeq, Dec 2012]

GeneCards Summary for BAIAP2L2 Gene

BAIAP2L2 (BAI1-Associated Protein 2-Like 2) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding and cytoskeletal adaptor activity. An important paralog of this gene is BAIAP2.

UniProtKB/Swiss-Prot for BAIAP2L2 Gene

  • Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAIAP2L2 Gene

Genomics for BAIAP2L2 Gene

Regulatory Elements for BAIAP2L2 Gene

Genomic Location for BAIAP2L2 Gene

38,084,883 bp from pter
38,110,964 bp from pter
26,082 bases
Minus strand

Genomic View for BAIAP2L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAIAP2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAIAP2L2 Gene

Proteins for BAIAP2L2 Gene

  • Protein details for BAIAP2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B0QYE2
    • Q96BG7

    Protein attributes for BAIAP2L2 Gene

    529 amino acids
    Molecular mass:
    58987 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BAIAP2L2 Gene


neXtProt entry for BAIAP2L2 Gene

Proteomics data for BAIAP2L2 Gene at MOPED

Post-translational modifications for BAIAP2L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BAIAP2L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BAIAP2L2 Gene

Domains for BAIAP2L2 Gene

Suggested Antigen Peptide Sequences for BAIAP2L2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6UXY1
  • The IMD domain consisting of an antiparallel dimer of three-helix bundles, featuring on one side a positively charged. The N-terminal alpha-helix inserts into the lipid bilayer. Also forms homodimers and homooligomers. The residue Trp-141 is essential for oligomer formation (By similarity).
  • Contains 1 IMD (IRSp53/MIM homology) domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with BAIAP2L2: view

No data available for Gene Families for BAIAP2L2 Gene

Function for BAIAP2L2 Gene

Molecular function for BAIAP2L2 Gene

UniProtKB/Swiss-Prot Function: Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity).

Gene Ontology (GO) - Molecular Function for BAIAP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005543 phospholipid binding ISS --
GO:0008093 cytoskeletal adaptor activity IBA --
GO:0017124 SH3 domain binding --
genes like me logo Genes that share ontologies with BAIAP2L2: view

Phenotypes for BAIAP2L2 Gene

GenomeRNAi human phenotypes for BAIAP2L2:
genes like me logo Genes that share phenotypes with BAIAP2L2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BAIAP2L2 Gene

Localization for BAIAP2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAIAP2L2 Gene

Cell membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane. Note=Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts.

Subcellular locations from

Jensen Localization Image for BAIAP2L2 Gene COMPARTMENTS Subcellular localization image for BAIAP2L2 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BAIAP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IBA --
GO:0005829 cytosol IBA --
GO:0005886 plasma membrane IEA --
GO:0012506 vesicle membrane IDA 21743456
GO:0015629 actin cytoskeleton IBA --
genes like me logo Genes that share ontologies with BAIAP2L2: view

Pathways for BAIAP2L2 Gene

SuperPathways for BAIAP2L2 Gene

No Data Available

Interacting Proteins for BAIAP2L2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000371085 for BAIAP2L2 Gene via STRING

Gene Ontology (GO) - Biological Process for BAIAP2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007009 plasma membrane organization IEA --
GO:0007165 signal transduction --
GO:0008286 insulin receptor signaling pathway IBA --
GO:0030838 positive regulation of actin filament polymerization IBA --
GO:0032956 regulation of actin cytoskeleton organization --
genes like me logo Genes that share ontologies with BAIAP2L2: view

No data available for Pathways by source for BAIAP2L2 Gene

Transcripts for BAIAP2L2 Gene

Unigene Clusters for BAIAP2L2 Gene

BAI1-associated protein 2-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BAIAP2L2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP2: -

Relevant External Links for BAIAP2L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BAIAP2L2 Gene

mRNA expression in normal human tissues for BAIAP2L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BAIAP2L2 Gene

This gene is overexpressed in Colon - Transverse (10.9), Small Intestine - Terminal Ileum (10.2), and Kidney - Cortex (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAIAP2L2 Gene

SOURCE GeneReport for Unigene cluster for BAIAP2L2 Gene Hs.474822

mRNA Expression by UniProt/SwissProt for BAIAP2L2 Gene

Tissue specificity: Expressed in the epithelial layer of the intestine (at protein level).
genes like me logo Genes that share expressions with BAIAP2L2: view

Orthologs for BAIAP2L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAIAP2L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BAIAP2L2 35
  • 99.05 (n)
  • 99.05 (a)
  • 99 (a)
(Bos Taurus)
Mammalia BAIAP2L2 36
  • 90 (a)
(Canis familiaris)
Mammalia BAIAP2L2 35
  • 89.15 (n)
  • 91.16 (a)
  • 79 (a)
(Mus musculus)
Mammalia Baiap2l2 35
  • 88.61 (n)
  • 92.13 (a)
Baiap2l2 16
Baiap2l2 36
  • 92 (a)
(Monodelphis domestica)
Mammalia BAIAP2L2 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia BAIAP2L2 36
  • 71 (a)
(Rattus norvegicus)
Mammalia Baiap2l2 35
  • 86.47 (n)
  • 89.42 (a)
(Gallus gallus)
Aves BAIAP2L2 36
  • 53 (a)
(Anolis carolinensis)
Reptilia BAIAP2L2 36
  • 62 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19687 35
tropical clawed frog
(Silurana tropicalis)
Amphibia baiap2l2 35
  • 59.19 (n)
  • 57.95 (a)
(Danio rerio)
Actinopterygii baiap2l2 35
  • 52.09 (n)
  • 48.91 (a)
baiap2l2 36
  • 35 (a)
BAIAP2L2 (1 of 2) 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32082 36
  • 11 (a)
Species with no ortholog for BAIAP2L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAIAP2L2 Gene

Gene Tree for BAIAP2L2 (if available)
Gene Tree for BAIAP2L2 (if available)

Paralogs for BAIAP2L2 Gene

Paralogs for BAIAP2L2 Gene

Selected SIMAP similar genes for BAIAP2L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BAIAP2L2: view

Variants for BAIAP2L2 Gene

Sequence variations from dbSNP and Humsavar for BAIAP2L2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs132927 -- 38,090,518(+) CTCTT(-/CTT)TTCAA intron-variant
rs132928 -- 38,090,731(+) GTGAC(C/G/T)GGCTC intron-variant
rs132929 -- 38,090,995(+) AACCC(A/G)AAGGC intron-variant
rs132930 -- 38,091,022(+) CAGAG(A/G)CATAA intron-variant
rs132931 -- 38,091,519(+) CTACT(A/G)TGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAIAP2L2 Gene

Variant ID Type Subtype PubMed ID
nsv915035 CNV Loss 21882294
nsv915053 CNV Loss 21882294
nsv834193 CNV Loss 17160897
dgv4968n71 CNV Loss 21882294
nsv471198 CNV Loss 18288195
dgv4969n71 CNV Loss 21882294
nsv834194 CNV Loss 17160897
esv2724223 CNV Deletion 23290073
nsv829205 CNV Loss 20364138
nsv829206 CNV Gain 20364138
nsv508732 CNV Insertion 20534489
nsv3623 CNV Insertion 18451855
esv996111 CNV Insertion 20482838
nsv513591 CNV Insertion 21212237
esv1386806 CNV Insertion 17803354

Relevant External Links for BAIAP2L2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAIAP2L2 Gene

Disorders for BAIAP2L2 Gene

No disorders were found for BAIAP2L2 Gene.

No data available for UniProtKB/Swiss-Prot for BAIAP2L2 Gene

Publications for BAIAP2L2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  4. Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. (PMID: 21743456) Pykalainen A. … Lappalainen P. (Nat. Struct. Mol. Biol. 2011) 3 4
  5. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3

Products for BAIAP2L2 Gene

Sources for BAIAP2L2 Gene

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