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Aliases & Descriptions for BAIAP2L1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ42275 2 | | IRTKS 1, 2, 3, 5 |
| | | Descriptions |
|---|
| BAI1-associated protein 2-like 1 2 | | BAI1-associated protein 2-like protein 1 3 | | Insulin receptor tyrosine kinase substrate 2, 3 | brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2 |
|
| | Search outside databases for aliases for BAIAP2L1 genePrevious GC identifer: GC07M097567 |
Summaries for BAIAP2L1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: BI2L1_HUMAN, Q9UHR4Function: May function as adapter protein (Potential). Involved in the formation of clusters of actin bundlesGene Wiki entry for BAIAP2L1 |
Genomic Location for BAIAP2L1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the BAIAP2L1 gene 
Entrez Gene cytogenetic band: 7q21.3 Ensembl cytogenetic band: 7q21.3 HGNC cytogenetic band: 7q22.1BAIAP2L1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M097760:
(about GC identifiers)
Start:
|
97,760,007 bp from pter |
End:
|
97,868,316 bp from pter |
Size:
|
108,310 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 97,247,421-97,353,984 |
RefSeq DNA sequence:- NC_000007.12 NT_007933.14 NT_079595.2
| Proteins for BAIAP2L1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: BI2L1_HUMAN, Q9UHR4 (See
protein sequence)Recommended Name: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 Size: 511 amino acids; 56883 Da
Subunit: Interacts with RAC1. Binds to F-actin
Sequence caution: Sequence=AAD20937.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D268 Q75L21 Q75L22 Q96CV4 Q9H5F5 Q9Y2M8Post-translational modifications:
Phosphorylated on tyrosine in response to insulin1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_061330.2
ENSEMBL proteins: ENSP00000005260
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | About this table
Antibodies for BAIAP2L1: Assays for BAIAP2L1: | Protein
Domains/ Families for BAIAP2L1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UHR4
ProtoNet protein and cluster: Q9UHR4 3 Blocks protein families: IPB001452 SH3 domain signature IPB011511 Variant SH3 IPB013606 IRSp53/MIM homology domain
UniProtKB/Swiss-Prot: BI2L1_HUMAN, Q9UHR4Domain: The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity)Similarity: Contains 1 IMD (IRSp53/MIM homology) domainSimilarity: Contains 1 SH3 domain | Gene Function for BAIAP2L1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018842
Applied Biosystems Silencer® siRNAs for BAIAP2L1
Sigma-Aldrich siRNA and siRNA Panels for BAIAP2L1  Sigma-Aldrich shRNA for BAIAP2L1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018842                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018842                                  untagged cDNA clones in CMV expression vector (see all 2): AK074419 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018842
UniProtKB/Swiss-Prot: BI2L1_HUMAN, Q9UHR4Function: May function as adapter protein (Potential). Involved in the formation of clusters of actin bundles4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for BAIAP2L1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for BAIAP2L1 (ENSP000000052603) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for BAIAP2L1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for BAIAP2L1 10/18 Novoseek chemical compound relationships for BAIAP2L1 gene (see all 18
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
87.25 |
435 |
7686917 (5), 1688432 (4), 7927191 (4), 9518262 (4) (see all 99) |
| phosphatidylinositol |
65.63 |
22 |
1722393 (3), 1688432 (3), 8058065 (2), 7520748 (1) (see all 14) |
| phosphotyrosine |
63.05 |
3 |
7520748 (1), 8071374 (1), 7592686 (1) |
| glucose |
55.29 |
26 |
7927191 (2), 2043221 (1), 1619013 (1), 8263133 (1) (see all 21) |
| vanadate |
53.93 |
3 |
8893518 (1), 8071374 (1), 8131857 (1) |
| glycogen |
52.15 |
8 |
15691882 (1), 8349045 (1), 9374504 (1), 1532777 (1) (see all 8) |
| threonine |
50.99 |
6 |
7615833 (1), 10871198 (1), 10923637 (1), 16020478 (1) (see all 6) |
| atp |
41.19 |
5 |
9312016 (2), 8058065 (1), 11886082 (1), 9678585 (1) |
| sphingosine |
30.11 |
2 |
1651108 (2) |
| mgatp |
15.98 |
2 |
2157363 (2) |
About this table
|
Transcripts for BAIAP2L1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018842
Sigma-Aldrich siRNA and siRNA Panels for BAIAP2L1  Sigma-Aldrich shRNA for BAIAP2L1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018842 REFSEQ mRNAs for BAIAP2L1 gene: NM_018842.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018842               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018842                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018842                                  untagged cDNA clones in CMV expression vector (see all 2): AK074419  Additional cDNA sequence: AK027109.1 AK027142.1 AK074419.1 AK309936.1 BC013888.2 17 DOTS entries: DT.207771 DT.100036527 DT.443716 DT.100776359 DT.40219849 DT.91721714 DT.121050185 DT.91721710 DT.91721717 DT.92423453 DT.100776358 DT.100776363 DT.121050301 DT.121050357 DT.91986070 DT.92464422 DT.87014983 24/228 AceView cDNA sequences (see all 228
):BQ233322 AA290961 AK074419 BF772783 BF732309 AI276862 BX095632 BC013888 BQ222513 BQ084262 CF528448 AA877610 BM810470 BQ011793 BE221334 BM551053 AA864398 AA283613 AI243179 AI382460 BM801655 AI272948 NM_018842 BG034422
highest scoring ESTs for BAIAP2L1:AI269306 AA195698 AA195732 AA227000 AA234954 AA235128 AA283613 AA290961 AA402490 AA427876 Unigene Cluster for BAIAP2L1: BAI1-associated protein 2-like 1 Hs.656063 [show with all ESTs]Unigene Representative Sequence: AK027142
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000005260
|
Expression for BAIAP2L1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| BAIAP2L1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for BAIAP2L1
1 / 2 / 3 9 probe-sets matching BAIAP2L1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.656063
|
Orthologs for BAIAP2L1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BAIAP2L1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for BAIAP2L1
ENSEMBL Gene Tree for BAIAP2L1 | Paralogs for BAIAP2L1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for BAIAP2L1 gene
- BAIAP2L22 BAIAP22
|
SNPs/Variants for BAIAP2L1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for BAIAP2L1 (up to first 250kb)
|
Disorders & Mutations for BAIAP2L1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611877
10/14 Novoseek disease relationships for BAIAP2L1 gene (see all 14
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leprechaunism |
65.99 |
1 |
9003010 (1) |
| insulin resistance |
65.54 |
20 |
7686917 (4), 1316361 (1), 7895862 (1), 10389840 (1) (see all 16) |
| insulin sensitivity |
60.64 |
7 |
8897006 (2), 7926300 (1), 16968801 (1), 14502098 (1) (see all 6) |
| niddm |
60.54 |
23 |
7927191 (4), 7821730 (2), 1846830 (2), 8393956 (2) (see all 14) |
| drpla |
55.48 |
2 |
11514062 (1), 10332026 (1) |
| insulin tolerance |
50.22 |
1 |
8897006 (1) |
| hyperinsulinemia |
42.43 |
2 |
9388499 (2) |
| hyperglycemia |
37.12 |
4 |
7508912 (1), 7821730 (1), 11225657 (1), 8529791 (1) |
| acanthosis nigricans |
30.93 |
1 |
9578241 (1) |
| diabetes gestational |
30.25 |
2 |
10871198 (1), 8336874 (1) |
About this table
|
Medical News for BAIAP2L1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for BAIAP2L1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/265 PubMed articles for BAIAP2L1 gene (see all 265
):- Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties. (PubMed id 17430976)1, 3, 4 Millard T.H....Machesky L.M. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)3, 4 Hillier L.W.... Wilson R.K. (2003)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)3, 4 Scherer S.W....Tsui L.C. (2003)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)3, 4 Hu R.-M.... Chen J.-L. (2000)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)4 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)4 Imami K.... Ishihama Y. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
|
Search for BAIAP2L1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing BAIAP2L1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing BAIAP2L1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BAIAP2L1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for BAIAP2L1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for BAIAP2L1:

|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|