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BAIAP2L1 Gene

protein-coding   GIFtS: 51

GC07M097760
BAI1-associated protein 2-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ42275 2
IRTKS 1, 2, 3, 5
Descriptions
BAI1-associated protein 2-like 1 2
BAI1-associated protein 2-like protein 1 3
Insulin receptor tyrosine kinase substrate 2, 3
brain-specific angiogenesis inhibitor 1-associated protein
2-like protein 1 2
External Ids
HGNC: 216491
Entrez Gene: 559712
UniProtKB: Q9UHR43
Ensembl: ENSG000000064537
Search outside databases for aliases for BAIAP2L1 gene

Previous GC identifer: GC07M097567

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: BI2L1_HUMAN, Q9UHR4
Function: May function as adapter protein (Potential). Involved in the formation of clusters of
actin bundles

Gene Wiki entry for BAIAP2L1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BAIAP2L1 gene  

Entrez Gene cytogenetic band: 7q21.3   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q22.1

BAIAP2L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M097760:     (about GC identifiers)

Start:
97,760,007 bp from pter
End:
97,868,316 bp from pter
Size:
108,310 bases
Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 97,247,421-97,353,984     
RefSeq DNA sequence:
NC_000007.12  NT_007933.14  NT_079595.2  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BI2L1_HUMAN, Q9UHR4 (See protein sequence)
Recommended Name: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1  
Size: 511 amino acids; 56883 Da
Subunit: Interacts with RAC1. Binds to F-actin
Sequence caution: Sequence=AAD20937.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D268 Q75L21 Q75L22 Q96CV4 Q9H5F5 Q9Y2M8

Post-translational modifications:

  • Phosphorylated on tyrosine in response to insulin1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_061330.2  

    ENSEMBL proteins: 
    ENSP00000005260 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (BAIAP2L1)
    Human Recombinant Proteins from Abnova (BAIAP2L1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575 cellular_component ND--
    About this table

    Antibodies for BAIAP2L1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for BAIAP2L1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (BAIAP2L1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (BAIAP2L1)
    Novus Biologicals Antibody for BAIAP2L1

    Assays for BAIAP2L1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR011511 SH3_2
     IPR001452 SH3_domain
     IPR013606 IRSp53/MIM_homology_IMD


       GeneDecks  BAIAP2L1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UHR4

    ProtoNet protein and cluster: Q9UHR4

    3 Blocks protein families:
    IPB001452 SH3 domain signature
    IPB011511 Variant SH3
    IPB013606 IRSp53/MIM homology domain


    UniProtKB/Swiss-Prot: BI2L1_HUMAN, Q9UHR4
    Domain: The IMD domain is predicted to have a helical structure. It may induce actin bundling and
    filopodia formation (By similarity)
    Similarity: Contains 1 IMD (IRSp53/MIM homology) domain
    Similarity: Contains 1 SH3 domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BAIAP2L1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BAIAP2L1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018842

                  Applied Biosystems Silencer® siRNAs for BAIAP2L1

                  Sigma-Aldrich siRNA and siRNA Panels for BAIAP2L1  
                         Sigma-Aldrich shRNA for BAIAP2L1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018842
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018842
                                     untagged cDNA clones in CMV expression vector (see all 2): AK074419 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_018842

    UniProtKB/Swiss-Prot: BI2L1_HUMAN, Q9UHR4
    Function: May function as adapter protein (Potential). Involved in the formation of clusters of
    actin bundles

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674 molecular_function ND--
    GO:0003779 actin binding IEA--
    GO:0008093 cytoskeletal adaptor activity IEA--
    GO:0017124 SH3 domain binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    4 Interacting proteins for BAIAP2L1 (ENSP000000052603) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHANK2ENSP000002940183STRING (score=.895)
    BAI1ENSP000003130463STRING (score=.835)
    CDC42P2ENSP000003144583STRING (score=.79)
    INSRENSP000003038303STRING (score=.721)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165 signal transduction IEA--
    GO:0008150 biological_process ND--
    GO:0046847 filopodium formation IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for BAIAP2L1
    10/18 Novoseek chemical compound relationships for BAIAP2L1 gene (see all 18 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 87.25 435 7686917 (5), 1688432 (4), 7927191 (4), 9518262 (4) (see all 99)
    phosphatidylinositol 65.63 22 1722393 (3), 1688432 (3), 8058065 (2), 7520748 (1) (see all 14)
    phosphotyrosine 63.05 3 7520748 (1), 8071374 (1), 7592686 (1)
    glucose 55.29 26 7927191 (2), 2043221 (1), 1619013 (1), 8263133 (1) (see all 21)
    vanadate 53.93 3 8893518 (1), 8071374 (1), 8131857 (1)
    glycogen 52.15 8 15691882 (1), 8349045 (1), 9374504 (1), 1532777 (1) (see all 8)
    threonine 50.99 6 7615833 (1), 10871198 (1), 10923637 (1), 16020478 (1) (see all 6)
    atp 41.19 5 9312016 (2), 8058065 (1), 11886082 (1), 9678585 (1)
    sphingosine 30.11 2 1651108 (2)
    mgatp 15.98 2 2157363 (2)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BAIAP2L1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BAIAP2L1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018842

                  Sigma-Aldrich siRNA and siRNA Panels for BAIAP2L1  
                         Sigma-Aldrich shRNA for BAIAP2L1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_018842  

    REFSEQ mRNAs for BAIAP2L1 gene: 

    NM_018842.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_018842  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018842
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018842
                                     untagged cDNA clones in CMV expression vector (see all 2): AK074419 

    Additional cDNA sequence: 

    AK027109.1 AK027142.1 AK074419.1 AK309936.1 BC013888.2 

    17 DOTS entries:

    DT.207771  DT.100036527  DT.443716  DT.100776359  DT.40219849  DT.91721714  DT.121050185  DT.91721710 
    DT.91721717  DT.92423453  DT.100776358  DT.100776363  DT.121050301  DT.121050357  DT.91986070  DT.92464422 
    DT.87014983 

    24/228 AceView cDNA sequences (see all 228 ):

    BQ233322 AA290961 AK074419 BF772783 BF732309 AI276862 BX095632 BC013888 
    BQ222513 BQ084262 CF528448 AA877610 BM810470 BQ011793 BE221334 BM551053 
    AA864398 AA283613 AI243179 AI382460 BM801655 AI272948 NM_018842 BG034422 

    highest scoring ESTs for BAIAP2L1:

    AI269306 AA195698 AA195732 AA227000 AA234954 AA235128 AA283613 AA290961 AA402490 AA427876 

    Unigene Cluster for BAIAP2L1:

    BAI1-associated protein 2-like 1
    Hs.656063  [show with all ESTs]
    Unigene Representative Sequence: AK027142


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000005260  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    BAIAP2L1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for BAIAP2L1

    1 / 2 / 3

    9 probe-sets matching BAIAP2L1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    59325_at2, 3 U95-C 1 1.00 1.00 0.91 1.13 AA628400 0.60 1.00 0.82 1
    65560_at2, 3 U95-C 1 1.00 1.00 0.92 1.01 N28444 0.60 1.00 0.82 1
    57084_s_at2, 3 U95-C 1 1.00 1.00 0.95 0.88 AW009817 0.60 1.00 0.82 1

    222675_s_at2, 3 U133-B 1 1.00 1.00 -- -- AA628400 0.60 1.00 0.82 1

    227371_at2, 3 U133-B 1 1.00 1.00 -- -- AA496034 0.60 1.00 0.82 1

    227372_s_at2, 3 U133-B 1 1.00 1.00 -- -- AA496034 0.60 1.00 0.82 1

    222675_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    227371_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    227372_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  BAIAP2L1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.656063
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for BAIAP2L1 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    BAIAP2L11   -- BAI1-associated protein 2-like 1 86.69(n)
    89.43(a)
    479748  XM_845195.1  XP_850288.1 
    chimpanzee
    (Pan troglodytes)
    BAIAP2L11   -- BAI1-associated protein 2-like 1 97.55(n)
    97.62(a)
    463559  XM_519222.2  XP_519222.2 
    rat
    (Rattus norvegicus)
    Baiap2l11   -- BAI1-associated protein 2-like 1 83.17(n)
    87.87(a)
    304282  NM_001034140.1  NP_001029312.1 
    mouse
    (Mus musculus)
    Baiap2l11, 5 55
    BAI1-associated protein 2-like 11, 5 84.09(n)1
    88.8(a)1
    668981  NM_025833.31  NP_080109.11 
     AI5858955  AK0049185  (see all 10)
    chicken
    (Gallus gallus)
    BAIAP2L11   -- BAI1-associated protein 2-like 1 70.97(n)
    71.83(a)
    416437  XM_414749.2  XP_414749.2 
    About this table        Species with no ortholog for BAIAP2L1

    ENSEMBL Gene Tree for BAIAP2L1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for BAIAP2L1 gene
    BAIAP2L22  BAIAP22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/667 NCBI SNPs in BAIAP2L1 are shown (see all 667 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 166)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 7 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs22699661,2
    C,F,H97771488(+) GGTGGA/TTGTCG 1 S/T mis18Minor allele frequency- T:0.06EA NA EU WA 2024
    rs128731,2
    A,C,F97760709(+) CAGGAT/CGCGCC 1 -- ut31 ese35Minor allele frequency- C:0.46MN NA 512
    rs10762721,2
    A,F,H97868941(+) GGCTGC/GCACTT 1 -- ng318Minor allele frequency- G:0.39NA EA MN EU WA 852
    rs47273911,2
    H97760125(+) CGGAGG/TAGATT 1 -- ng514Minor allele frequency- T:0.00EU EA WA 412
    --
    rs125339821,2
    C97868449(+) GCGGGA/GCCCGG 1 -- ng310--------
    --
    rs47273931,2
    C97870182(+) aatccC/Gagcac 1 -- ng310--------
    rs9581171,2
    H97777815(+) ATTTAG/AAAAGG 1 F/S mis15Minor allele frequency- A:0.00MN EU EA WA 602
    rs127281,2
    A,C,F,H97760787(+) GGTGCC/TGAGCG 1 S/S syn1 ese310Minor allele frequency- T:0.36MN NA EU EA WA 1002
    rs10459161,2
    A,C,F,H97771537(-) TGCTTA/GTCCAT 1 L/L syn1 ese312Minor allele frequency- G:0.34EA MN NA EU WA 2266
    rs130081,2
    A,C,F,H97760811(+) GTCGGG/ACGGAG 1 R/R syn1 ese314Minor allele frequency- A:0.24MN NA EU EA WA 1416
    About this table

    HapMap Linkage Disequilibrium images for BAIAP2L1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 611877

    10/14 Novoseek disease relationships for BAIAP2L1 gene (see all 14 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    leprechaunism 65.99 1 9003010 (1)
    insulin resistance 65.54 20 7686917 (4), 1316361 (1), 7895862 (1), 10389840 (1) (see all 16)
    insulin sensitivity 60.64 7 8897006 (2), 7926300 (1), 16968801 (1), 14502098 (1) (see all 6)
    niddm 60.54 23 7927191 (4), 7821730 (2), 1846830 (2), 8393956 (2) (see all 14)
    drpla 55.48 2 11514062 (1), 10332026 (1)
    insulin tolerance 50.22 1 8897006 (1)
    hyperinsulinemia 42.43 2 9388499 (2)
    hyperglycemia 37.12 4 7508912 (1), 7821730 (1), 11225657 (1), 8529791 (1)
    acanthosis nigricans 30.93 1 9578241 (1)
    diabetes gestational 30.25 2 10871198 (1), 8336874 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/265 PubMed articles for BAIAP2L1 gene (see all 265 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 55971 HGNC: 21649 AceView: LOC55971 Ensembl:ENSG00000006453 euGenes: HUgn55971
    ECgene: BAIAP2L1 H-InvDB: BAIAP2L1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for BAIAP2L1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for BAIAP2L1 Antibodies for BAIAP2L1
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