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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BAIAP2L1 Gene

protein-coding   GIFtS: 51
GCID: GC07M097920

BAI1-associated protein 2-like 1
 Explore 24 diseases affiliated with
BAIAP2L1 via
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Biological research products
for BAIAP2L1    

Aliases
for BAIAP2L1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
BAI1-Associated Protein 2-Like 11 2
IRTKS1 2 3 5
Insulin Receptor Tyrosine Kinase Substrate2 3
BAI1-Associated Protein 2-Like Protein 12 3
Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2-Like Protein 12

External Ids:    HGNC: 216491   Entrez Gene: 559712   Ensembl: ENSG000000064537   OMIM: 6118775   UniProtKB: Q9UHR43   

Export aliases for BAIAP2L1 gene to outside databases

Previous GC identifers: GC07M097567 GC07M097760 GC07M092521


Summaries
for BAIAP2L1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BAIAP2L1:
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in
two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The
protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a
canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for
insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways
that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly
and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin
assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: BI2L1_HUMAN, Q9UHR4
Function: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the
reorganization of the actin cytoskeleton in response to bacterial infection

Gene Wiki entry for BAIAP2L1


Genomic Views
for BAIAP2L1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BAIAP2L1 gene promoter:
         NF-AT4   NF-AT2   p53   POU3F1   NF-AT3   AP-2alpha   AP-2alphaA   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BAIAP2L1 promoter sequence
   Search SABiosciences Chromatin IP Primers for BAIAP2L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAIAP2L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

BAIAP2L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAIAP2L1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M097920:  view genomic region     (about GC identifiers)

Start:
 97,920,962 bp from pter      End:
 98,030,427 bp from pter
Size:
 109,466 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 97,245,828-97,354,031     

Proteins
for BAIAP2L1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BI2L1_HUMAN, Q9UHR4 (See protein sequence)
Recommended Name: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1  
Size: 511 amino acids; 56883 Da
Subunit: Interacts with RAC1. Binds to F-actin. Interacts with FASLG. Interacts (via SH3 domain) with E.coli effector
protein EspF(U) (via PXXP motifs). Identified in a complex containing at least WASL, BAIAP2L1 and E.coli EspF(U).
Interacts with E.coli intimin receptor Tir
Subcellular location: Cytoplasm, cytoskeleton. Note=Recruited to actin pedestals that are formed upon infection by
bacteria at bacterial attachment sites
Sequence caution: Sequence=AAD20937.1; Type=Erroneous gene model prediction; Sequence=AAS07549.1; Type=Erroneous
initiation; Sequence=BAB15671.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for BAIAP2L1:
2KXC (3D)        2LNH (3D)    
Secondary accessions: A4D268 Q75L21 Q75L22 Q96CV4 Q9H5F5 Q9Y2M8

Explore the universe of human proteins at neXtProt for BAIAP2L1: NX_Q9UHR4

Post-translational modifications:

  • Phosphorylated on tyrosine in response to insulin1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UHR4

    • BAIAP2L1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061330.2  
    ENSEMBL proteins: 
     ENSP00000005260  

    Human Recombinant Protein Products: 
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    Novus Biologicals BAIAP2L1 Proteins
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    Uscn Proteins for BAIAP2L1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA19366662
    GO:0005886plasma membrane IDA--


    BAIAP2L1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for BAIAP2L1

    Protein Domains /
    Families
    for BAIAP2L1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BAIAP2L1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011511 SH3_2
     IPR001452 SH3_domain
     IPR013606 IRSp53/MIM_homology_IMD

    Graphical View of Domain Structure for InterPro Entry Q9UHR4

    ProtoNet protein and cluster: Q9UHR4

    3 Blocks protein families:
    IPB001452 SH3 domain signature
    IPB011511 Variant SH3
    IPB013606 IRSp53/MIM homology domain


    UniProtKB/Swiss-Prot: BI2L1_HUMAN, Q9UHR4
    Domain: The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation
    (By similarity)
    Similarity: Contains 1 IMD (IRSp53/MIM homology) domain
    Similarity: Contains 1 SH3 domain


    Function
    for BAIAP2L1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BI2L1_HUMAN, Q9UHR4
    Function: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the
    reorganization of the actin cytoskeleton in response to bacterial infection

    miRNA
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    hsa-miR-3163 hsa-miR-137 hsa-miR-188-5p hsa-miR-548e hsa-miR-340 hsa-miR-764 hsa-miR-548a-3p hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: BAIAP2L1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0008093cytoskeletal adaptor activity IEA--
    GO:0017124SH3 domain binding IEA--
    GO:0070064proline-rich region binding IDA--


    BAIAP2L1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for BAIAP2L1:
     Decreased POU5F1-GFP protein e  Synthetic lethal with c-Myc af 


    Pathways & Interactions
    for BAIAP2L1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BAIAP2L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/21 Interacting proteins for BAIAP2L1 (Q9UHR43 ENSP000000052604) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAA2P546463, ENSP000003602904I2D: score=3 STRING: ENSP00000360290
    PRKAB2O437413, ENSP000002541014I2D: score=3 STRING: ENSP00000254101
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    TERF1P542743, ENSP000002766034I2D: score=1 STRING: ENSP00000276603
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0009617response to bacterium IDA19366662
    GO:0030838positive regulation of actin filament polymerization IDA--
    GO:0046847filopodium assembly IEA--
    GO:2000251positive regulation of actin cytoskeleton reorganization IMP19366662


    BAIAP2L1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BAIAP2L1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BAIAP2L1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BAIAP2L1
    10/26 Novoseek chemical compound relationships for BAIAP2L1 gene (see all 26)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 87 437 7686917 (5), 1688432 (4), 7927191 (4), 9518262 (4) (see all 99)
    phosphatidylinositol 65 22 1722393 (3), 1688432 (3), 8058065 (2), 7520748 (1) (see all 14)
    phosphotyrosine 62.7 3 7520748 (1), 8071374 (1), 7592686 (1)
    glucose 54.3 26 7927191 (2), 2043221 (1), 1619013 (1), 8263133 (1) (see all 21)
    vanadate 53.7 3 8893518 (1), 8071374 (1), 8131857 (1)
    serine 53.6 13 7818531 (1), 8948451 (1), 7615833 (1), 10871198 (1) (see all 10)
    glycogen 51.3 8 15691882 (1), 8349045 (1), 9374504 (1), 1532777 (1) (see all 8)
    metformin 51.1 10 8529763 (3), 19237574 (1), 15135305 (1), 17953367 (1) (see all 5)
    phenylarsine oxide 51.1 2 1848858 (1)
    threonine 50.3 6 7615833 (1), 10871198 (1), 10923637 (1), 16020478 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about BAIAP2L1 / BI2L1 

    Transcripts
    for BAIAP2L1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BAIAP2L1 gene: 
    NM_018842.4  

    Unigene Cluster for BAIAP2L1:

    BAI1-associated protein 2-like 1
    Hs.656063  [show with all ESTs]
    Unigene Representative Sequence: NM_018842
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000005260(uc003upj.3) ENST00000480580 ENST00000462558 ENST00000473569
    ENST00000479789

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate BAIAP2L1 (see all 12):
    hsa-miR-3163 hsa-miR-137 hsa-miR-188-5p hsa-miR-548e hsa-miR-340 hsa-miR-764 hsa-miR-548a-3p hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: BAIAP2L1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BAIAP2L1 (see all 6)
    OriGene siRNA: BAIAP2L1
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF119666.2 AK027109.1 AK027142.1 AK074419.1 AK309936.1 BC013888.2 

    17 DOTS entries:

    DT.207771  DT.100036527  DT.443716  DT.100776359  DT.91721714  DT.121050185  DT.40219849  DT.91721710 
    DT.92423453  DT.100776358  DT.100776363  DT.121050301  DT.121050357  DT.91721717  DT.91986070  DT.92464422 
    DT.87014983 

    24/228 AceView cDNA sequences (see all 228):

    BC013888 BM810470 BM852920 AA290961 BM796385 AI628595 AI382460 AI961555 
    BQ084262 AA427876 BF818966 BF772783 CF528448 BF817094 BF732309 BQ233322 
    AI269306 BQ222513 BE221334 BQ011793 AI272948 BG682313 AI818554 AK074419 

    GeneLoc Exon Structure


    Expression
    for BAIAP2L1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BAIAP2L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCTGGTCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BAIAP2L1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    LiverLiver LobulePeriportal HepatocytesLiver
    BrainChoroid PlexusBrain
    BrainMedulla OblongataBrain
    Gut TubeMidgutGut Tube
    Neural TubeDiencephalic Roof PlateNeural Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

    See BAIAP2L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BAIAP2L1

    SOURCE GeneReport for Unigene cluster: Hs.656063
        SABiosciences Custom PCR Arrays for BAIAP2L1
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAIAP2L1

    Orthologs
    for BAIAP2L1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for BAIAP2L1 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BAIAP2L11 BAI1-associated protein 2-like 1 70.97(n)
    71.83(a)    		   416437  XM_414749.3  XP_414749.2 
    lizard
    (Anolis carolinensis)    		 Reptilia BAIAP2L16
    		 --
    		 66(a)
    		 1 ↔ 1
    		 GL344247.1(861-23524)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC688222 hypothetical protein MGC68822 74.7(n)    BC061676.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii loc559712 insulin receptor tyrosine kinase substrate homolog more 72.62(n)   387261  AY398378.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG320826
    		 --
    		 9(a)
    		 1 → many
    		 3L(11129149-11157084)


    ENSEMBL Gene Tree for BAIAP2L1 (if available)
    TreeFam Gene Tree for BAIAP2L1 (if available) 

    Paralogs
    for BAIAP2L1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BAIAP2L1 gene
    BAIAP2L22  BAIAP22  
    2 SIMAP similar genes for BAIAP2L1 using alignment to 1 protein entry:     BI2L1_HUMAN:
    BAIAP2    BAIAP2L2

    BAIAP2L1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BAIAP2L1
    PGOHUM00000240664


    Genomic Variants
    for BAIAP2L1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1975 NCBI SNPs in BAIAP2L1 are shown (see all 1975)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs119732471,2
    		C,F,H,--92523602(+) CCAGCG/ATGGTC 1 -- int18Minor allele frequency- A:0.01NS EA NA WA 536
    rs731473371,2
    		C,F,--92523701(+) GCACCG/AAAGGC 1 -- int11Minor allele frequency- A:0.06NA 120
    rs102377671,2
    		C,F,H,--92524122(+) GAAAAC/TGCTCT 1 -- int17Minor allele frequency- T:0.01NS EA NA 868
    rs731473391,2
    		C,,--92524361(+) GCCACA/GGTCTT 1 -- int10--------
    rs767459401,2
    		C,F,--92524568(+) CAACTC/TCTTCC 1 -- int11Minor allele frequency- T:0.05NA 120
    rs774670061,2
    		C,--92524836(+) GAGGCC/TCTCTC 1 -- int11Minor allele frequency- T:0.01WA 118
    rs774431491,2
    		C,--92524943(+) AGGCTG/ATGGAG 1 -- int12Minor allele frequency- A:0.07CSA WA 120
    rs765068191,2
    		C,--92524947(+) TGTGGA/GGACGG 1 -- int10--------
    rs1137078001,2
    		--92526489(+) TCCCTC/TTCCAC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs119762311,2
    		C,F,H,--92526748(+) CATGTC/TCTGTG 1 -- int16Minor allele frequency- T:0.01NS EA WA 528

    HapMap Linkage Disequilibrium report for BAIAP2L1 (97920962 - 98030427 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for BAIAP2L1
         2 Indels: 70007 28722

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BAIAP2L1
    DNA2.0 Custom Variant and Variant Library Synthesis for BAIAP2L1

    Disorders / Diseases
    for BAIAP2L1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BAIAP2L1 for disorders           About GeneDecksing

    OMIM gene information: 611877    OMIM disorders: --

    20/24 diseases for BAIAP2L1 (see all 24):    About MalaCards
    dentatorubral-pallidoluysian atrophy    acanthosis nigricans    type 2 diabetes mellitus    insulin resistance
    essential hypertension    diabetes mellitus    gestational diabetes    hyperandrogenism
    hyperglycemia    rheumatoid arthritis    hypertension    breast cancer
    noma    leiomyoma    renal carcinoma    homocysteine
    colon carcinoma    t-cell leukemia    neurodegeneration    arthritis

    1 disease from the University of Copenhagen DISEASES database for BAIAP2L1:
    dentatorubral-pallidoluysian atrophy

    10/14 Novoseek disease relationships for BAIAP2L1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leprechaunism 65.6 1 9003010 (1)
    insulin resistance 64.8 21 7686917 (4), 1316361 (1), 7895862 (1), 10389840 (1) (see all 17)
    insulin sensitivity 60.3 7 8897006 (2), 7926300 (1), 16968801 (1), 14502098 (1) (see all 6)
    niddm 59.5 23 7927191 (4), 7821730 (2), 1846830 (2), 8393956 (2) (see all 14)
    drpla 55 2 11514062 (1), 10332026 (1)
    insulin tolerance 49.1 1 8897006 (1)
    hyperinsulinemia 41.8 2 9388499 (2)
    hyperglycemia 35.8 4 7508912 (1), 7821730 (1), 11225657 (1), 8529791 (1)
    acanthosis nigricans 29.8 1 9578241 (1)
    diabetes gestational 28.7 2 10871198 (1), 8336874 (1)


    Export disorders for BAIAP2L1 gene to outside databases

    Publications
    for BAIAP2L1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BAIAP2L1 gene, integrated from 9 sources (see all 288):
    (articles sorted by number of sources associating them with BAIAP2L1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties. (PubMed id 17430976)1, 2, 9 Millard T.H....Machesky L.M. (2007)
    2. Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly. (PubMed id 21098279)1, 2 Aitio O.... Permi P. (2010)
    3. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
    4. Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal format ion. (PubMed id 19366662)1, 2 Vingadassalom D....Leong J.M. (2009)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    9. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    10. A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid ho rmone regulation. (PubMed id 22829776)1 Coviello A.D....Perry J.R. (2012)

    External Searches for BAIAP2L1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing BAIAP2L1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55971 HGNC: 21649 AceView: LOC55971 Ensembl:ENSG00000006453 euGenes: HUgn55971
    ECgene: BAIAP2L1 H-InvDB: BAIAP2L1

    Other Databases showing BAIAP2L1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BAIAP2L1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BAIAP2L1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for BAIAP2L1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BAIAP2L1 gene:
    Search GeneIP for patents involving BAIAP2L1

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