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BAIAP2 Gene

protein-coding GIFtS: 62

GC17P076623

BAI1-associated protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BAP2 ^¹, ²
FLAF3 ^², ³
IRS-58 ^³
IRSP53 ^², ⁵
IRSp53 ^³
IRSp53/58 ^³

Descriptions
BAI-associated protein 2 ^³
BAI1-associated protein 2 ^², ³
Fas ligand-associated factor 3 ^², ³
Insulin receptor substrate p53 ^², ³
Insulin receptor substrate p53/p58 ^², ³
Insulin receptor substrate protein of 53 kDa ^³
Protein BAP2 ^³
brain-specific angiogenesis inhibitor 1-associated protein 2 ^²

External Ids
HGNC: 947¹
Entrez Gene: 10458²
UniProtKB: Q9UQB8³
Ensembl: ENSG00000175866⁷

Search outside databases for aliases for BAIAP2 gene

Previous GC identifers: GC17U990151 GC17P082371 GC17P079571 GC17P079709

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for BAIAP2:

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor

(BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic

effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and

suggests a role for insulin in the central nervous system. It also associates with a downstream

effector of Rho small G proteins, which is associated with the formation of stress fibers and

cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and

may affect neuronal growth-cone guidance. This protein has also been identified as interacting

with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant

neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding

distinct isoforms.

UniProtKB/Swiss-Prot: BAIP2_HUMAN, Q9UQB8

Function: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector

proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for

RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF

family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with

ENAH to promote filipodia formation

Gene Wiki entry for BAIAP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BAIAP2 gene

Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25

BAIAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P076623: (about GC identifiers)

Start:	76,623,546 bp from pter
End:	76,705,827 bp from pter
Size:	82,282 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_024871.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BAIP2_HUMAN, Q9UQB8 (See protein sequence)

Recommended Name: Brain-specific angiogenesis inhibitor 1-associated protein 2

Size: 552 amino acids; 60868 Da

Subunit: Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding.

Interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH

after recruitment of CDC42. Interacts with TIAM1 and DIAPH1 (By similarity)

Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Cell projection,

filopodium. Cell projection, ruffle. Note=Detected throughout the cytoplasm in the absence of

specific binding partners. Detected in filopodia and close to membrane ruffles

Caution: It is uncertain whether Met-1 or Met-59 is the initiator

PDB structure from and Proteopedia :

1WDZ (3D)

1Y2O (3D)

Secondary accessions: O43858 Q53HB1 Q86WC1 Q8N5C0 Q96CR7 Q9UBR3 Q9UQ43

Alternative splicing: 6 isoforms: Q9UQB8-1 Q9UQB8-2 Q9UQB8-3 Q9UQB8-4 Q9UQB8-5 Q9UQB8-6

Post-translational modifications:

Phosphorylated on tyrosine residues by INSR in response to insulin treatment¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001138360.1 NP_006331.1 NP_059344.1 NP_059345.1

ENSEMBL proteins:

ENSP00000316338 ENSP00000376211 ENSP00000313974 ENSP00000315685

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BAI1 associated protein 2 isoform 3, BAIAP2)
	Human Recombinant Proteins from Abnova (BAIAP2)

OriGene Purified Recombinant Human Protein: BAIAP2

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	10343108
GO:0005886	plasma membrane	TAS	10343108
GO:0042995	cell projection	IEA	--

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Antibodies for BAIAP2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of BAIAP2
	Sigma-Aldrich Antibodies for BAIAP2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (BAI1 associated protein 2 isoform 3, BAIAP2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BAIAP2)
	Novus Biologicals Antibodies for BAIAP2

Assays for BAIAP2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UQB8

ProtoNet protein and cluster: Q9UQB8

3 Blocks protein families:

IPB001452 SH3 domain signature

IPB011511 Variant SH3

IPB013606 IRSp53/MIM homology domain

UniProtKB/Swiss-Prot: BAIP2_HUMAN, Q9UQB8

Domain: The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and

filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and

the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with

RAC1 or CDC42 leads to activation

Domain: The SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH

Similarity: Contains 1 IMD (IRSp53/MIM homology) domain

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BAIAP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BAIAP2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001144888

Applied Biosystems Silencer® siRNAs for BAIAP2

Sigma-Aldrich siRNA and siRNA Panels for BAIAP2

Sigma-Aldrich shRNA for BAIAP2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BAIAP2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001144888
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001144888
untagged cDNA clones in CMV expression vector (see all 4): NM_001144888

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_017451

UniProtKB/Swiss-Prot: BAIP2_HUMAN, Q9UQB8

Function: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector

proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for

RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF

family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with

ENAH to promote filipodia formation

Genatlas biochemistry entry for BAIAP2:

brain specific angiogenesis (BAI1) inhibitor-associated protein 2,expressed in neurons,with two

isoforms,long expressed in brain,short in other tissue,MAGUK (membrane-associted guanylase kinase

homolog) family,homolog of hamster IRSP53

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Baiap2):

behavior/neurological

life span-post-weaning/aging

nervous system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008022	protein C-terminus binding	TAS	10343108
GO:0008093	cytoskeletal adaptor activity	TAS	10343108
GO:0017124	SH3 domain binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for BAIAP2 (Your Favorite Gene powered by Ingenuity)

Regulation of Actin-based Motility by Rho
Axonal Guidance Signaling
Actin Cytoskeleton Signaling

GeneDecks BAIAP2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for BAIAP2

5/40 Interacting proteins for BAIAP2 (Q9UQB8^{1, 2} ENSP00000316338³) via UniProtKB, MINT, and/or STRING (see all 40 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
WASF2	Q9Y6W5², ENSP00000363131³	MINT-15179 MINT-15180 MINT-15178 STRING (score=.999)
ATN1	P54259², ENSP00000349076³	MINT-2868323 MINT-50907 MINT-50909 STRING (score=.998)
ABI1	Q8IZP0¹, ENSP00000347555³	EBI-525456, EBI-375446 STRING (score=.936)
EPS8	Q12929¹^,², ENSP00000281172³	EBI-525456, EBI-375576 MINT-68438 EBI-525456, EBI-375576 MINT-68438 STRING (score=.991)
PBX2	P40425¹^,²	EBI-525456, EBI-348489 MINT-62572 MINT-62670 MINT-62746 EBI-525456, EBI-348489 MINT-62572 MINT-62670 MINT-62746

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007409	axonogenesis	TAS	10343108
GO:0008286	insulin receptor signaling pathway	TAS	10343108
GO:0046847	filopodium formation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BAIAP2
1 Novoseek chemical compound relationship for BAIAP2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	46.49	20	18417251 (7), 11514062 (1), 15635447 (1), 12884081 (1) (see all 8)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BAIAP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BAIAP2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001144888

Sigma-Aldrich siRNA and siRNA Panels for BAIAP2

Sigma-Aldrich shRNA for BAIAP2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006340 NM_017450 NM_017451

REFSEQ mRNAs for BAIAP2 gene (4 alternative transcripts):

NM_001144888.1 NM_006340.2 NM_017450.2 NM_017451.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006340 NM_017450 NM_017451

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001144888
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001144888
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001144888

Additional cDNA sequence:

AB015019.1 AB015020.1 AB017119.1 AB017120.1 AK023688.1 AK056888.1 AK127291.1 AK222670.1

AK225612.1 AK297644.1 AK298629.1 AK301436.1 BC002495.2 BC014020.2 BC032559.1 U70669.1

24/30 DOTS entries (see all 30 ):

DT.100885089 DT.106708 DT.92444973 DT.100885084 DT.75168840 DT.95226934 DT.100885080 DT.443448

DT.95226944 DT.75172568 DT.120937425 DT.92444964 DT.95226962 DT.100697561 DT.40246617 DT.97759993

DT.100803282 DT.120937354 DT.95132854 DT.120937357 DT.120937385 DT.40212091 DT.442429 DT.75140322

24/341 AceView cDNA sequences (see all 341 ):

BG060086 AW299831 AA349114 AI459980 CB111778 BM928074 BQ651827 BM474938

BQ432153 U70669 BQ710494 BE252378 AI611036 BF446922 BQ652839 BC032559

AI093313 BQ941292 AL556018 Z41362 BI824231 BQ428473 BM848150 BQ227723

highest scoring ESTs for BAIAP2:

AB015019 AB015020 AA236944 AA349114 AA513463 AA631876 AA644152 AA854934 AA860146 AA923249

Unigene Cluster for BAIAP2:

BAI1-associated protein 2

Hs.128316 [show with all ESTs]

Unigene Representative Sequence: AK127291

GeneLoc Exon Structure

5/23 Alternative Splicing Database (ASD) splice patterns (SP) for BAIAP2 (see all 23 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	·	14c	^	15a	·	15b	·	15c	^	16	^	17	^	18	^	19a	·
SP1:					-		-		-				-		-		-		-				-		-		-				-		-												-		-
SP2:							-		-				-		-		-		-				-		-		-				-		-				-								-		-
SP3:					-		-		-				-		-		-		-				-		-		-				-		-												-		-
SP4:					-		-		-				-		-		-		-				-		-		-				-		-												-		-
SP5:																																													-		-

ExUns:	19b	·	19c	^	20a	·	20b	^	21a	·	21b	^	22a	·	22b	^	23	^	24a	·	24b	^	25	^	26a	·	26b
SP1:													-								-
SP2:													-
SP3:													-
SP4:													-
SP5:													-								-

About this scheme

ECgene alternative splicing isoforms for BAIAP2

4 Ensembl transcripts including schematic representations:

ENST00000321300 ENST00000392411 ENST00000321238 ENST00000321280

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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BAIAP2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BAIAP2

¹ / ² / ³

10 probe-sets matching BAIAP2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37761_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.87	AB015020	0.80	1.00	0.91	1
37760_at²^{, 3}	U95-A	1	1.00	1.00	0.65	1.15	AB015019	0.80	1.00	0.91	1
209502_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC002495	0.60	1.00	0.82	1
207832_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_017451	0.40	0.67	0.55	1
205293_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB017120	0.60	1.00	0.82	1
205294_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_017450	0.60	1.00	0.82	1
209502_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207832_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205293_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205294_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks BAIAP2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGCCTTGGG

SOURCE GeneReport for Unigene cluster: Hs.128316
Expression variation in blood from EXPOLDB for BAIAP2
UniProtKB/Swiss-Prot: BAIP2_HUMAN, Q9UQB8
Tissue specificity: Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is
barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the
highest expression in liver, prostate, testis and placenta

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BAIAP2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BAIAP2¹	--	BAI1-associated protein 2	89.2(n) 95.14(a)	403473 XM_533131.2 XP_533131.2
chimpanzee (Pan troglodytes)	BAIAP2¹	--	BAI1-associated protein 2	94.9(n) 93.62(a)	454951 XM_511730.2 XP_511730.2
cow (Bos taurus)	BAIAP2¹	--	BAI1-associated protein 2	90.28(n) 94.13(a)	507837 NM_001017937.1 NP_001017937.1
rat (Rattus norvegicus)	Baiap2¹	--	BAI1-associated protein 2	87.61(n) 95.69(a)	117542 NM_057196.1 NP_476544.1
mouse (Mus musculus)	Baiap2^{1, 5}	11⁵	brain-specific angiogenesis inhibitor 1-associated more^{1, 5}	87.9(n)¹ 97.03(a)¹	108100¹ NM_001037754.2¹ NP_001032843.1¹ AA796998⁵ AB105196⁵ (see all 26)

About this table Species with no ortholog for BAIAP2

ENSEMBL Gene Tree for BAIAP2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for BAIAP2 gene

BAIAP2L2² BAIAP2L1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/571 NCBI SNPs in BAIAP2 are shown (see all 571 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 194)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11150764^1,2	A,C,F,H	76621670(+)	`CCAGGA/CGAGCA`	3	--	ng5¹		4		EU EA WA	412
	rs11664^1,2	A,C,F,H	76697457(-)	`GAAAAC/TGGACG`	3	--	int¹ ut3¹ ese³		14		MN EA NA EU WA	1404
--	rs4072587^1,2	A,C,F	76698943(-)	`ACGCAC/TGCCGG`	3	--	int¹ ng3¹		4		EA NA	214
--	rs4072589^1,2	A,C	76699060(-)	`GTGAGC/TGACTG`	3	--	int¹ ng3¹		0	--	--	--	--
--	rs4072588^1,2	A,C	76698667(-)	`CCTTGA/CGCTCT`	3	--	int¹ ut3¹ ese³		0	--	--	--	--
--	rs3935190^1,2	A,C	76698962(-)	`CGGGGC/TCCCCA`	3	--	int¹ ng3¹		0	--	--	--	--
	rs12450554^1,2	C	76622667(+)	`TCCAAA/GATCCT`	3	--	ng5¹		0	--	--	--	--
	rs1127508^1,2	F	76698487(+)	`TGAGTG/TCAGGG`	3	--	int¹ ut3¹ ese³		1		MN	184
	rs12944344^1,2	F	76704405(+)	`GGGCCG/AGGCAG`	2	--	int¹ ut3¹ ese³		4		NA EA	362
	rs12449515^1,2	C	76705362(+)	`TTCCAC/TCCTGG`	1	--	ut3¹ ese³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for BAIAP2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 605475

3 Novoseek disease relationships for BAIAP2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
drpla	82.96	11	10222779 (3), 10332026 (3), 11514062 (2), 12884081 (1)
wiskott-aldrich syndrome	72.65	4	15673667 (1), 14752106 (1)
neurodegenerative diseases	17.08	1	12884081 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/52 PubMed articles for BAIAP2 gene (see all 52 ):

Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. (PubMed id 10343108)^{1, 2, 3, 4} Oda K.... Tokino T. (1999)
A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. (PubMed id 14752106)^{1, 3, 4} Yamagishi A.... Mochizuki N. (2004)
Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. (PubMed id 11696321)^{1, 3, 4} Krugmann S....Hall A. (2001)
Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53. (PubMed id 15635447)^{1, 3, 4} Millard T.H.... Fuetterer K. (2005)
Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate. (PubMed id 10332026)^{1, 3, 4} Okamura-Oho Y.... Yamada M. (1999)
Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein. (PubMed id 12884081)^{1, 3, 4} Miyahara A.... Yamada M. (2003)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness. (PubMed id 15289329)^{3, 4} Funato Y.... Miki H. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42. (PubMed id 12504591)^{3, 4} Soltau M.... Kreienkamp H.-J. (2002)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10458	HGNC: 947	AceView: BAIAP2	Ensembl:ENSG00000175866	euGenes: HUgn10458
ECgene: BAIAP2	H-InvDB: BAIAP2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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BAIAP2 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for BAIAP2

Summaries
for BAIAP2

Genomic Location
for BAIAP2

Proteins
for BAIAP2

Protein Domains/
Families
for BAIAP2

Gene Function
for BAIAP2

Pathways & Interactions
for BAIAP2

Drugs & Compounds
for BAIAP2

Transcripts
for BAIAP2

Expression
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for BAIAP2

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Genome Databases showing BAIAP2

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for BAIAP2

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for BAIAP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BAIAP2 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor BAIAP2

Summariesfor BAIAP2

Genomic Locationfor BAIAP2

Proteinsfor BAIAP2

Protein Domains/Familiesfor BAIAP2

Gene Functionfor BAIAP2

Pathways & Interactionsfor BAIAP2

Drugs & Compoundsfor BAIAP2

Transcriptsfor BAIAP2

Expression for BAIAP2

Orthologsfor BAIAP2

Paralogsfor BAIAP2

SNPs/Variantsfor BAIAP2

Disorders & Mutationsfor BAIAP2

Medical Newsfor BAIAP2

Publicationsfor BAIAP2

Search for BAIAP2

Genome Databases showing BAIAP2

Other Databases showing BAIAP2

Specialized Databases showing BAIAP2

Licensable Technologiesfor BAIAP2

Servicesfor BAIAP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BAIAP2

Summaries
for BAIAP2

Genomic Location
for BAIAP2

Proteins
for BAIAP2

Protein Domains/
Families
for BAIAP2

Gene Function
for BAIAP2

Pathways & Interactions
for BAIAP2

Drugs & Compounds
for BAIAP2

Transcripts
for BAIAP2

Expression
for BAIAP2

Orthologs
for BAIAP2

Paralogs
for BAIAP2

SNPs/Variants
for BAIAP2

Disorders & Mutations
for BAIAP2

Medical News
for BAIAP2

Publications
for BAIAP2

Licensable Technologies
for BAIAP2

Services
for BAIAP2