Aliases for BAIAP2 Gene
External Ids for BAIAP2 Gene
Previous GeneCards Identifiers for BAIAP2 Gene
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
GeneCards Summary for BAIAP2 Gene
BAIAP2 (BAI1 Associated Protein 2) is a Protein Coding gene. Diseases associated with BAIAP2 include Dentatorubro-Pallidoluysian Atrophy and Attention Deficit-Hyperactivity Disorder. Among its related pathways are Actin Nucleation by ARP-WASP Complex and PAK Pathway. GO annotations related to this gene include identical protein binding and SH3 domain binding. An important paralog of this gene is BAIAP2L1.
UniProtKB/Swiss-Prot for BAIAP2 Gene
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.