Aliases for BAIAP2 Gene
Aliases for BAIAP2 Gene
External Ids for BAIAP2 Gene
- HGNC: 947
- Entrez Gene: 10458
- Ensembl: ENSG00000175866
- OMIM: 605475
- UniProtKB: Q9UQB8
Previous GeneCards Identifiers for BAIAP2 Gene
- GC17U990151
- GC17P082371
- GC17P079571
- GC17P079709
- GC17P076623
- GC17P079008
- GC17P074448
Summaries for BAIAP2 Gene
-
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
GeneCards Summary for BAIAP2 Gene
BAIAP2 (BAI1 Associated Protein 2) is a Protein Coding gene. Diseases associated with BAIAP2 include Dentatorubro-Pallidoluysian Atrophy. Among its related pathways are Innate Immune System and RET signaling. GO annotations related to this gene include identical protein binding and SH3 domain binding. An important paralog of this gene is BAIAP2L1.
UniProtKB/Swiss-Prot for BAIAP2 Gene
-
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAIAP2 Gene
Genomics for BAIAP2 Gene
Regulatory Elements for BAIAP2 Gene
Enhancers for BAIAP2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around BAIAP2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for BAIAP2 Gene
- Chromosome:
- 17
- Start:
- 81,035,122 bp from pter
- End:
- 81,117,432 bp from pter
- Size:
- 82,311 bases
- Orientation:
- Plus strand
Genomic View for BAIAP2 Gene
Genes around BAIAP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by Ensembl
- 17q25.3 by Entrez Gene
- 17q25.3 by HGNC
BAIAP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BAIAP2 Gene
Proteins for BAIAP2 Gene
-
Protein details for BAIAP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UQB8-BAIP2_HUMAN
- Recommended name:
- Brain-specific angiogenesis inhibitor 1-associated protein 2
- Protein Accession:
- Q9UQB8
- O43858
- Q53HB1
- Q86WC1
- Q8N5C0
- Q96CR7
- Q9UBR3
- Q9UQ43
Protein attributes for BAIAP2 Gene
- Size:
- 552 amino acids
- Molecular mass:
- 60868 Da
- Quaternary structure:
-
- Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42. Interacts with TIAM1 and DIAPH1 (By similarity). Interacts (via SH3 domain) with E.coli effector protein EspF(U) (via PXXP motifs). Interacts with E.coli intimin receptor Tir.
Three dimensional structures from OCA and Proteopedia for BAIAP2 Gene
Protein Expression for BAIAP2 Gene
Post-translational modifications for BAIAP2 Gene
- Phosphorylated on tyrosine residues by INSR in response to insulin treatment.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for BAIAP2 Gene
- ENSEMBL proteins:
-
- ENSP00000315685
- ENSP00000391837
- ENSP00000401022
- ENSP00000413069
- ENSP00000458202
- ENSP00000458440
- ENSP00000458494
- ENSP00000458522
- ENSP00000458735
- ENSP00000458964
- ENSP00000459730
- ENSP00000459787
- ENSP00000460131
- ENSP00000460344
- ENSP00000460350
- ENSP00000460492
- ENSP00000461101
- ENSP00000461144
- ENSP00000461736
- ENSP00000316338
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for BAIAP2
- Novus Biologicals Antibodies for BAIAP2
-
Abcam antibodies for BAIAP2
- Invitrogen Antibodies for BAIAP2
- antibodies-online Antibodies for BAIAP2: See all 127
- GeneTex BAIAP2 antibody for BAIAP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for BAIAP2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for BAIAP2
- Origene Custom Protein Services for BAIAP2
- ProSpec Recombinant Proteins for BAIAP2
- antibodies-online Proteins for BAIAP2: See all 10
- Search antibodies-online for peptides
- Search GeneTex for Proteins for BAIAP2
-
Abcam proteins for BAIAP2
Assay Products
No data available for DME Specific Peptides for BAIAP2 Gene
Domains & Families for BAIAP2 Gene
Gene Families for BAIAP2 Gene
Protein Domains for BAIAP2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for BAIAP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UQB8UniProtKB/Swiss-Prot:
BAIP2_HUMAN :- The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation.
- Domain:
-
- The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation.
- The SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.
Function for BAIAP2 Gene
Molecular function for BAIAP2 Gene
- GENATLAS Biochemistry:
- brain specific angiogenesis (BAI1) inhibitor-associated protein 2,expressed in neurons,with two isoforms,long expressed in brain,short in other tissue,MAGUK (membrane-associted guanylase kinase homolog) family,homolog of hamster IRSP53
- UniProtKB/Swiss-Prot Function:
- Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001221 | transcription cofactor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 11157984 |
| GO:0008022 | protein C-terminus binding | TAS | 10343108 |
| GO:0008093 | cytoskeletal adaptor activity | IEA | -- |
| GO:0030165 | PDZ domain binding | IEA | -- |
Phenotypes for BAIAP2 Gene
- MGI mutant phenotypes for BAIAP2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for BAIAP2:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased transferrin (TF) endocytosis
- Wnt reporter downregulated
- Increased cell number in S
- Decreased influenza A/WSN/33 replication
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
Animal Models for BAIAP2 Gene
- MGI Knock Outs for BAIAP2:
-
- Baiap2 tm1b(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BAIAP2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for BAIAP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BAIAP2 gene
- Search ViGene Biosciences for BAIAP2
CRISPR Products
-
OriGene CRISPR knockouts for BAIAP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for BAIAP2
- GenScript: Design CRISPR guide RNA sequences for BAIAP2
miRNA for BAIAP2 Gene
- miRTarBase miRNAs that target BAIAP2
miRNA Products
- Search ViGene Biosciences for BAIAP2
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for BAIAP2
- Browse OriGene Inhibitory RNA Products For BAIAP2
-
ViGene Biosciences ready-to-package AAV shRNAs for BAIAP2 gene
Clone Products
- Sino Biological Human cDNA Clone for BAIAP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for BAIAP2
- VectorBuilder custom plasmid, inducible vectors for BAIAP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAIAP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for BAIAP2
-
ViGene Biosciences adenoviral particle packaged cDNA for BAIAP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for BAIAP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BAIAP2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BAIAP2 Gene
Localization for BAIAP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BAIAP2 Gene
- Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 3 |
| golgi apparatus | 3 |
| endoplasmic reticulum | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | IEA | -- |
| GO:0005737 | cytoplasm | TAS | 10343108 |
| GO:0005791 | rough endoplasmic reticulum | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005829 | cytosol | TAS,IDA | -- |
Pathways & Interactions for BAIAP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Actin Nucleation by ARP-WASP Complex |
.41
|
.35
|
| 2 | Regulation of actin dynamics for phagocytic cup formation | ||
| 3 | G-protein signaling RAC1 in cellular process | ||
| 4 | Regulation of actin cytoskeleton | ||
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
.65
|
|
Pathways by source for BAIAP2 Gene
4 BioSystems pathways for BAIAP2 Gene
10 Reactome pathways for BAIAP2 Gene
2 KEGG pathways for BAIAP2 Gene
1 GeneGo (Thomson Reuters) pathway for BAIAP2 Gene
8 Qiagen pathways for BAIAP2 Gene
Interacting Proteins for BAIAP2 Gene
Selected Interacting proteins:
ENSP00000316338
Q9UQB8-BAIP2_HUMAN
for BAIAP2 Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for BAIAP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007009 | plasma membrane organization | IEA | -- |
| GO:0007409 | axonogenesis | TAS | 10343108 |
| GO:0007420 | brain development | IEA | -- |
| GO:0008286 | insulin receptor signaling pathway | TAS | 10343108 |
| GO:0008360 | regulation of cell shape | ISS,IEA | -- |
Drugs & Compounds for BAIAP2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
Transcripts for BAIAP2 Gene
mRNA/cDNA for BAIAP2 Gene
- (19) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (341) Selected AceView cDNA sequences:
- (30) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for BAIAP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for BAIAP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for BAIAP2
- GenScript: Design CRISPR guide RNA sequences for BAIAP2
miRNA Products
- Search ViGene Biosciences for BAIAP2
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for BAIAP2
- Browse OriGene Inhibitory RNA Products For BAIAP2
-
ViGene Biosciences ready-to-package AAV shRNAs for BAIAP2 gene
Clone Products
- Sino Biological Human cDNA Clone for BAIAP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for BAIAP2
- VectorBuilder custom plasmid, inducible vectors for BAIAP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAIAP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: |
| ExUns: | 19b | · | 19c | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||
| SP14: | - | - | - | ||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||
| SP19: | |||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||
| SP21: | |||||||||||||||||||||||||||
| SP22: | |||||||||||||||||||||||||||
| SP23: |
Expression for BAIAP2 Gene
This gene is overexpressed in Cervix (30.7), Brain (16.3), and Frontal cortex (10.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BAIAP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of BAIAP2 Gene:
BAIAP2SOURCE GeneReport for Unigene cluster for BAIAP2 Gene:
Hs.128316mRNA Expression by UniProt/SwissProt for BAIAP2 Gene:
Q9UQB8-BAIP2_HUMAN
Tissue specificity:
Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta.
Evidence on tissue expression from TISSUES for BAIAP2 Gene
- Nervous system(5)
- Intestine(4.3)
- Liver(4.3)
- Eye(3.2)
- Lung(2.2)
Primer Products
-
OriGene qPCR primer pairs for BAIAP2
-
OriGene qPCR primer pairs and template standards for BAIAP2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAIAP2 Gene
Orthologs for BAIAP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BAIAP2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | BAIAP2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | BAIAP2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | BAIAP2 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Baiap2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Baiap2 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | BAIAP2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BAIAP2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | BAIAP2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | baiap2 34 |
|
||
| Str.6299 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | baiap2a 34 35 |
|
||
| baiap2b 35 |
|
OneToMany | |||
| BAIAP2 (1 of 3) 35 |
|
OneToMany | |||
| wufk29g02 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG32082 35 |
|
OneToMany |
- Species where no ortholog for BAIAP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for BAIAP2 Gene
(2) SIMAP similar genes for BAIAP2 Gene using alignment to 17 proteins:
Variants for BAIAP2 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000000998 | -- | 81,050,599(+) | CCAAG(C/T)GCGTG | intron-variant | |
| rs1000003985 | -- | 81,100,972(+) | GAGAC(C/T)CCTCT | intron-variant | |
| rs1000009015 | -- | 81,083,815(+) | GGAAA(C/T)ATCTG | intron-variant | |
| rs1000016524 | -- | 81,074,583(+) | GATGT(A/G)TGAGT | intron-variant | |
| rs1000030400 | -- | 81,050,423(+) | ACCTT(A/G)GTGCT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3292n100 | CNV | gain | 25217958 |
| esv26223 | CNV | gain+loss | 19812545 |
| esv2716421 | CNV | deletion | 23290073 |
| esv2716422 | CNV | deletion | 23290073 |
| esv2716423 | CNV | deletion | 23290073 |
| esv2716424 | CNV | deletion | 23290073 |
| esv3641391 | CNV | loss | 21293372 |
| nsv1065052 | CNV | gain | 25217958 |
| nsv1066947 | CNV | loss | 25217958 |
| nsv1072760 | CNV | deletion | 25765185 |
| nsv112250 | CNV | deletion | 16902084 |
| nsv1130710 | CNV | deletion | 24896259 |
| nsv1133415 | CNV | deletion | 24896259 |
| nsv1138585 | CNV | deletion | 24896259 |
| nsv470619 | CNV | loss | 18288195 |
| nsv523417 | CNV | gain | 19592680 |
| nsv576169 | CNV | loss | 21841781 |
| nsv576170 | CNV | gain | 21841781 |
| nsv576171 | CNV | loss | 21841781 |
| nsv828128 | CNV | loss | 20364138 |
| nsv828131 | CNV | loss | 20364138 |
| nsv828132 | CNV | loss | 20364138 |
| nsv833564 | CNV | loss | 17160897 |
| nsv952388 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
9.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.61;
13.15% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for BAIAP2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAIAP2 Gene
Disorders for BAIAP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dentatorubro-pallidoluysian atrophy |
|
Search BAIAP2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for BAIAP2
No data available for UniProtKB/Swiss-Prot and Genatlas for BAIAP2 Gene
Publications for BAIAP2 Gene
- Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. (PMID: 10343108) Oda K. … Tokino T. (Cytogenet. Cell Genet. 1999) 2 3 4 22 64
- IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation. (PMID: 19286134) Weiss S.M. … Stradal T.E. (Cell Host Microbe 2009) 3 4 22 64
- Regulation of cell shape by Cdc42 is mediated by the synergic actin- bundling activity of the Eps8-IRSp53 complex. (PMID: 17115031) Disanza A. … Scita G. (Nat. Cell Biol. 2006) 3 4 22 64
- Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53. (PMID: 15635447) Millard T.H. … Fuetterer K. (EMBO J. 2005) 3 4 22 64
- A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. (PMID: 14752106) Yamagishi A. … Mochizuki N. (J. Biol. Chem. 2004) 3 4 22 64
Products for BAIAP2 Gene
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- antibodies-online Proteins for BAIAP2: See all 10
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for BAIAP2 Gene
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