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Aliases for BAIAP2 Gene

Aliases for BAIAP2 Gene

  • BAI1-Associated Protein 2 2 3 4
  • IRSP53 3 4 6
  • Insulin Receptor Substrate Protein Of 53 KDa 3 4
  • Insulin Receptor Substrate P53/P58 3 4
  • Fas Ligand-Associated Factor 3 3 4
  • IRSp53/58 3 4
  • IRS-58 3 4
  • FLAF3 3 4
  • Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2 3
  • Insulin Receptor Substrate P53 4
  • BAI-Associated Protein 2 4
  • Protein BAP2 4
  • BAP2 3

External Ids for BAIAP2 Gene

Summaries for BAIAP2 Gene

Entrez Gene Summary for BAIAP2 Gene

  • The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

GeneCards Summary for BAIAP2 Gene

BAIAP2 (BAI1-Associated Protein 2) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include identical protein binding and SH3 domain binding. An important paralog of this gene is BAIAP2L2.

UniProtKB/Swiss-Prot for BAIAP2 Gene

  • Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.

Gene Wiki entry for BAIAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAIAP2 Gene

Genomics for BAIAP2 Gene

Genomic Location for BAIAP2 Gene

Start:
81,035,122 bp from pter
End:
81,117,432 bp from pter
Size:
82,311 bases
Orientation:
Plus strand

Genomic View for BAIAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAIAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAIAP2 Gene

Regulatory Elements for BAIAP2 Gene

Proteins for BAIAP2 Gene

  • Protein details for BAIAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQB8-BAIP2_HUMAN
    Recommended name:
    Brain-specific angiogenesis inhibitor 1-associated protein 2
    Protein Accession:
    Q9UQB8
    Secondary Accessions:
    • O43858
    • Q53HB1
    • Q86WC1
    • Q8N5C0
    • Q96CR7
    • Q9UBR3
    • Q9UQ43

    Protein attributes for BAIAP2 Gene

    Size:
    552 amino acids
    Molecular mass:
    60868 Da
    Quaternary structure:
    • Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42. Interacts with TIAM1 and DIAPH1 (By similarity). Interacts (via SH3 domain) with E.coli effector protein EspF(U) (via PXXP motifs). Interacts with E.coli intimin receptor Tir.

    Three dimensional structures from OCA and Proteopedia for BAIAP2 Gene

    Alternative splice isoforms for BAIAP2 Gene

neXtProt entry for BAIAP2 Gene

Proteomics data for BAIAP2 Gene at MOPED

Post-translational modifications for BAIAP2 Gene

  • Phosphorylated on tyrosine residues by INSR in response to insulin treatment.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BAIAP2 Gene

Domains for BAIAP2 Gene

UniProtKB/Swiss-Prot:

BAIP2_HUMAN
Domain:
  • The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation.:
    • Q9UQB8
  • The SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.:
    • Q9UQB8
  • Contains 1 IMD (IRSp53/MIM homology) domain.:
    • Q9UQB8
  • Contains 1 SH3 domain.:
    • Q9UQB8
genes like me logo Genes that share domains with BAIAP2: view

No data available for Gene Families for BAIAP2 Gene

Function for BAIAP2 Gene

Molecular function for BAIAP2 Gene

GENATLAS Biochemistry: brain specific angiogenesis (BAI1) inhibitor-associated protein 2,expressed in neurons,with two isoforms,long expressed in brain,short in other tissue,MAGUK (membrane-associted guanylase kinase homolog) family,homolog of hamster IRSP53
UniProtKB/Swiss-Prot Function: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.

Gene Ontology (GO) - Molecular Function for BAIAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11130076
GO:0008022 protein C-terminus binding TAS 10343108
GO:0008093 cytoskeletal adaptor activity IEA --
GO:0017124 SH3 domain binding --
GO:0042802 identical protein binding IPI 11696321
genes like me logo Genes that share ontologies with BAIAP2: view
genes like me logo Genes that share phenotypes with BAIAP2: view

miRNA for BAIAP2 Gene

miRTarBase miRNAs that target BAIAP2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BAIAP2 Gene

Localization for BAIAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAIAP2 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAIAP2 Gene COMPARTMENTS Subcellular localization image for BAIAP2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 4
plasma membrane 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BAIAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with BAIAP2: view

Pathways for BAIAP2 Gene

genes like me logo Genes that share pathways with BAIAP2: view

Gene Ontology (GO) - Biological Process for BAIAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007009 plasma membrane organization IEA --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007409 axonogenesis TAS 10343108
GO:0008286 insulin receptor signaling pathway TAS 10343108
genes like me logo Genes that share ontologies with BAIAP2: view

Compounds for BAIAP2 Gene

(1) HMDB Compounds for BAIAP2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(2) Novoseek inferred chemical compound relationships for BAIAP2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 45.8 15
glutamine 36.8 3
genes like me logo Genes that share compounds with BAIAP2: view

Transcripts for BAIAP2 Gene

Unigene Clusters for BAIAP2 Gene

BAI1-associated protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BAIAP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - -
SP6: - - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14:
SP15: - - - - - - -
SP16: - - - -
SP17:
SP18: - - - - - - - -
SP19: - - - - - - - - - -
SP20: - - - - - - -
SP21: - - -
SP22: -
SP23:

ExUns: 19b · 19c ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b
SP1: - -
SP2: -
SP3: -
SP4: -
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for BAIAP2 Gene

GeneLoc Exon Structure for
BAIAP2
ECgene alternative splicing isoforms for
BAIAP2

Expression for BAIAP2 Gene

mRNA expression in normal human tissues for BAIAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAIAP2 Gene

SOURCE GeneReport for Unigene cluster for BAIAP2 Gene Hs.128316

mRNA Expression by UniProt/SwissProt for BAIAP2 Gene

Q9UQB8-BAIP2_HUMAN
Tissue specificity: Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta.
genes like me logo Genes that share expressions with BAIAP2: view

Orthologs for BAIAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAIAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAIAP2 36
  • 97.88 (n)
  • 98 (a)
BAIAP2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAIAP2 36
  • 90.28 (n)
  • 94.13 (a)
BAIAP2 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAIAP2 36
  • 89.08 (n)
  • 94.93 (a)
BAIAP2 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Baiap2 36
  • 87.82 (n)
  • 95.83 (a)
Baiap2 16
Baiap2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BAIAP2 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAIAP2 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Baiap2 36
  • 87.61 (n)
  • 95.69 (a)
chicken
(Gallus gallus)
Aves BAIAP2 36
  • 81.62 (n)
  • 86.21 (a)
BAIAP2 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BAIAP2 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia baiap2 36
  • 74.37 (n)
  • 81.08 (a)
Str.6299 36
zebrafish
(Danio rerio)
Actinopterygii BAIAP2 (1 of 3) 37
  • 40 (a)
OneToMany
baiap2a 36
  • 70.66 (n)
  • 69.92 (a)
baiap2a 37
  • 65 (a)
OneToMany
baiap2b 37
  • 61 (a)
OneToMany
wufk29g02 36
fruit fly
(Drosophila melanogaster)
Insecta CG32082 37
  • 13 (a)
OneToMany
Species with no ortholog for BAIAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAIAP2 Gene

ENSEMBL:
Gene Tree for BAIAP2 (if available)
TreeFam:
Gene Tree for BAIAP2 (if available)

Paralogs for BAIAP2 Gene

Paralogs for BAIAP2 Gene

genes like me logo Genes that share paralogs with BAIAP2: view

Variants for BAIAP2 Gene

Sequence variations from dbSNP and Humsavar for BAIAP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs11664 -- 81,109,062(-) GAAAA(C/T)GGACG intron-variant, utr-variant-3-prime
rs1127508 -- 81,110,092(+) TGAGT(G/T)CAGGG intron-variant, utr-variant-3-prime
rs1801854 -- 81,109,119(+) CCTGC(C/T)CCATG intron-variant, utr-variant-3-prime
rs3934492 -- 81,060,164(-) ACCGG(C/G)AAGAA intron-variant
rs3935139 -- 81,059,717(+) gactg(C/G)tggga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAIAP2 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
dgv3304n71 CNV Loss 21882294
nsv909000 CNV Loss 21882294
nsv909009 CNV Gain 21882294
dgv3306n71 CNV Loss 21882294
dgv3307n71 CNV Loss 21882294
dgv3308n71 CNV Loss 21882294
dgv3309n71 CNV Loss 21882294
nsv833564 CNV Loss 17160897
nsv909021 CNV Loss 21882294
nsv470619 CNV Loss 18288195
dgv3310n71 CNV Loss 21882294
nsv828131 CNV Loss 20364138
esv2716421 CNV Deletion 23290073
esv2716422 CNV Deletion 23290073
nsv112250 CNV Loss 16902084
esv2716423 CNV Deletion 23290073
dgv3311n71 CNV Loss 21882294
dgv3312n71 CNV Loss 21882294
dgv3313n71 CNV Loss 21882294
nsv909037 CNV Loss 21882294
dgv3314n71 CNV Loss 21882294
esv2716424 CNV Deletion 23290073
nsv828132 CNV Loss 20364138
nsv523417 CNV Gain 19592680
nsv909047 CNV Gain 21882294
dgv3315n71 CNV Loss 21882294

Relevant External Links for BAIAP2 Gene

HapMap Linkage Disequilibrium report
BAIAP2
Human Gene Mutation Database (HGMD)
BAIAP2

Disorders for BAIAP2 Gene

(1) University of Copenhagen DISEASES for BAIAP2 Gene

(3) Novoseek inferred disease relationships for BAIAP2 Gene

Disease -log(P) Hits PubMed IDs
drpla 81.5 9
wiskott-aldrich syndrome 77.8 2
neurodegenerative diseases 12.3 1

Relevant External Links for BAIAP2

Genetic Association Database (GAD)
BAIAP2
Human Genome Epidemiology (HuGE) Navigator
BAIAP2
genes like me logo Genes that share disorders with BAIAP2: view

No data available for UniProtKB/Swiss-Prot for BAIAP2 Gene

Publications for BAIAP2 Gene

  1. Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. (PMID: 10343108) Oda K. … Tokino T. (Cytogenet. Cell Genet. 1999) 2 3 4 23
  2. Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate. (PMID: 10332026) Okamura-Oho Y. … Yamada M. (Hum. Mol. Genet. 1999) 3 4 23
  3. Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. (PMID: 11696321) Krugmann S. … Hall A. (Curr. Biol. 2001) 3 4 23
  4. Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein. (PMID: 12884081) Miyahara A. … Yamada M. (J. Hum. Genet. 2003) 3 4 23
  5. A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. (PMID: 14752106) Yamagishi A. … Mochizuki N. (J. Biol. Chem. 2004) 3 4 23

Products for BAIAP2 Gene

Sources for BAIAP2 Gene

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