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BAIAP2 Gene

protein-coding   GIFtS: 68
GCID: GC17P079008

BAI1-Associated Protein 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BAI1-Associated Protein 21 2 3     IRSP532 5
Fas Ligand-Associated Factor 32 3     BAP22
Insulin Receptor Substrate P53/P582 3     Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 22
Insulin Receptor Substrate Protein Of 53 KDa2 3     IRSp533
FLAF32 3     BAI-Associated Protein 23
IRS-582 3     Insulin Receptor Substrate P533
IRSp53/582 3     Protein BAP23

External Ids:    HGNC: 9471   Entrez Gene: 104582   Ensembl: ENSG000001758667   OMIM: 6054755   UniProtKB: Q9UQB83   

Export aliases for BAIAP2 gene to outside databases

Previous GC identifers: GC17U990151 GC17P082371 GC17P079571 GC17P079709 GC17P076623 GC17P074448


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BAIAP2 Gene:
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding
protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein
functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous
system. It also associates with a downstream effector of Rho small G proteins, which is associated with the
formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in
motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting
with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant
neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct
isoforms.(provided by RefSeq, Jan 2009)

GeneCards Summary for BAIAP2 Gene:
BAIAP2 (BAI1-associated protein 2) is a protein-coding gene. Diseases associated with BAIAP2 include dentatorubral-pallidoluysian atrophy, and wiskott-aldrich syndrome. GO annotations related to this gene include SH3 domain binding and identical protein binding. An important paralog of this gene is BAIAP2L2.

UniProtKB/Swiss-Prot: BAIP2_HUMAN, Q9UQB8
Function: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary
for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in
the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite
growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the
actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8,
promoting filopodial protrusions

Gene Wiki entry for BAIAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BAIAP2 gene promoter:
         AML1a   Tal-1   SREBP-1c   Nkx2-5   LCR-F1   E47   Evi-1   SREBP-1b   SREBP-1a   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BAIAP2 promoter sequence
   Search Chromatin IP Primers for BAIAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BAIAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

BAIAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAIAP2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P079008:  view genomic region     (about GC identifiers)

Start:
79,008,947 bp from pter      End:
79,091,232 bp from pter
Size:
82,286 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BAIP2_HUMAN, Q9UQB8 (See protein sequence)
Recommended Name: Brain-specific angiogenesis inhibitor 1-associated protein 2  
Size: 552 amino acids; 60868 Da
Subunit: Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1,
BAI1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42. Interacts
with TIAM1 and DIAPH1 (By similarity). Interacts (via SH3 domain) with E.coli effector protein EspF(U) (via PXXP
motifs). Interacts with E.coli intimin receptor Tir
Caution: It is uncertain whether Met-1 or Met-59 is the initiator
4 PDB 3D structures from and Proteopedia for BAIAP2:
1WDZ (3D)        1Y2O (3D)        2YKT (3D)        3RNJ (3D)    
Secondary accessions: O43858 Q53HB1 Q86WC1 Q8N5C0 Q96CR7 Q9UBR3 Q9UQ43
Alternative splicing: 6 isoforms:  Q9UQB8-1   Q9UQB8-2   Q9UQB8-3   Q9UQB8-4   Q9UQB8-5   Q9UQB8-6   

Explore the universe of human proteins at neXtProt for BAIAP2: NX_Q9UQB8

Explore proteomics data for BAIAP2 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues by INSR in response to insulin treatment1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BAIAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001138360.1  NP_006331.1  NP_059344.1  NP_059345.1  

    ENSEMBL proteins: 
     ENSP00000460344   ENSP00000458494   ENSP00000315685   ENSP00000460492   ENSP00000401022  
     ENSP00000458964   ENSP00000461144   ENSP00000413069   ENSP00000316338   ENSP00000458202  
     ENSP00000460131   ENSP00000458522   ENSP00000461736   ENSP00000459787   ENSP00000458735  
     ENSP00000459730   ENSP00000461101   ENSP00000458440   ENSP00000391837   ENSP00000460350  
     ENSP00000376211  
    Reactome Protein details: Q9UQB8

    BAIAP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for BAIAP2
    OriGene Protein Over-expression Lysate for BAIAP2
    OriGene MassSpec for BAIAP2
    OriGene Custom Protein Services for BAIAP2
    GenScript Custom Purified and Recombinant Proteins Services for BAIAP2
    Novus Biologicals BAIAP2 Proteins
    Novus Biologicals BAIAP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for BAIAP2
    Cloud-Clone Corp. Proteins for BAIAP2

    BAIAP2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BAIAP2
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    Abcam antibodies for BAIAP2
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    ThermoFisher Antibody for BAIAP2
    LSBio Antibodies in human, mouse, rat for BAIAP2

    BAIAP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for BAIAP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BAIAP2
    Cloud-Clone Corp. CLIAs for BAIAP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001452 SH3_domain
     IPR013606 IRSp53/MIM_homology_IMD
     IPR027681 BAIAP2

    Graphical View of Domain Structure for InterPro Entry Q9UQB8

    ProtoNet protein and cluster: Q9UQB8

    3 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB011511 Variant SH3
    IPB013606 IRSp53/MIM homology domain


    UniProtKB/Swiss-Prot: BAIP2_HUMAN, Q9UQB8
    Domain: The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation.
    In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an
    auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation
    Domain: The SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH
    Similarity: Contains 1 IMD (IRSp53/MIM homology) domain
    Similarity: Contains 1 SH3 domain


    BAIAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BAIP2_HUMAN, Q9UQB8
    Function: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary
    for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in
    the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite
    growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the
    actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8,
    promoting filopodial protrusions

         Genatlas biochemistry entry for BAIAP2:
    brain specific angiogenesis (BAI1) inhibitor-associated protein 2,expressed in neurons,with two isoforms,long
    expressed in brain,short in other tissue,MAGUK (membrane-associted guanylase kinase homolog) family,homolog of
    hamster IRSP53

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11130076
    GO:0008022protein C-terminus binding TAS10343108
    GO:0008093cytoskeletal adaptor activity IEA--
    GO:0017124SH3 domain binding IEA--
    GO:0042802identical protein binding IPI11696321
         
    BAIAP2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for BAIAP2:
     Decreased influenza A/WSN/33 r  Increased cell number in G2M,   Upregulation of Wnt/beta-caten  Wnt reporter downregulated 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Baiap2):
     behavior/neurological  mortality/aging  nervous system 

    BAIAP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BAIAP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BAIAP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BAIAP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BAIAP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target BAIAP2:
    hsa-mir-455-3p (MIRT037874)

    Block miRNA regulation of human, mouse, rat BAIAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BAIAP2 (see all 50):
    hsa-miR-4272 hsa-miR-513a-5p hsa-miR-15a hsa-miR-485-3p hsa-miR-29a hsa-miR-3167 hsa-miR-1304 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidBAIAP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BAIAP2
    Predesigned siRNA for gene silencing in human, mouse, rat BAIAP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BAIAP2

    Clone
    Products:
         
    OriGene clones in human, mouse for BAIAP2 (see all 26)
    OriGene ORF clones in mouse, rat for BAIAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): BAIAP2 (NM_017451)
    Sino Biological Human cDNA Clone for BAIAP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BAIAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAIAP2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for BAIAP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAIAP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BAIP2_HUMAN, Q9UQB8: Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell
    projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific
    binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are
    formed upon infection by bacteria at bacterial attachment sites
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    nucleus4
    plasma membrane4
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm TAS10343108
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS10343108

    BAIAP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BAIAP2 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    CDC42 Pathway0.41
    3Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    4Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    Actin-Based Motility by Rho Family GTPases0.62
    5CDC42 signaling events
    CDC42 signaling events0.34
    RAC1 signaling pathway0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BAIAP2 (see all 8)
        RhoA Pathway
    Actin-Based Motility by Rho Family GTPases
    CDC42 Pathway
    Actin Nucleation by ARP-WASP Complex
    Epithelial Adherens Junctions

    1 GeneGo (Thomson Reuters) Pathway for BAIAP2
        G-protein signaling RAC1 in cellular process

    4 BioSystems Pathways for BAIAP2
        Regulation of Actin Cytoskeleton
    CDC42 signaling events
    ErbB1 downstream signaling
    RAC1 signaling pathway


    1 Reactome Pathway for BAIAP2
        Regulation of actin dynamics for phagocytic cup formation


    2 Kegg Pathways  (Kegg details for BAIAP2):
        Adherens junction
    Regulation of actin cytoskeleton


    BAIAP2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BAIAP2: 
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BAIAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BAIAP2 (Q9UQB81, 2, 3 ENSP000003163384) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225987P404252, 3, ENSP000004039484MINT-62572 MINT-62670 MINT-62746 I2D: score=4 STRING: ENSP00000403948
    ENSG00000237344P404252, 3, ENSP000003971774MINT-62572 MINT-62670 MINT-62746 I2D: score=4 STRING: ENSP00000397177
    PBX2P404252, 3, ENSP000003641904MINT-62572 MINT-62670 MINT-62746 I2D: score=4 STRING: ENSP00000364190
    ENSG00000206315P404252, 3MINT-62572 MINT-62670 MINT-62746 I2D: score=4 
    ENSG00000224952P404252, 3MINT-62572 MINT-62670 MINT-62746 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007409axonogenesis TAS10343108
    GO:0008286insulin receptor signaling pathway TAS10343108
    GO:0008360regulation of cell shape ISS--
    GO:0009617response to bacterium IMP19366662

    BAIAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BAIAP2 (BAIP2)

    1 HMDB Compound for BAIAP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for BAIAP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 45.8 21 18417251 (7), 11514062 (1), 15635447 (1), 19889090 (1) (see all 9)
    glutamine 36.8 3 11514062 (1), 10222779 (1), 10332026 (1)



    BAIAP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BAIAP2 gene (4 alternative transcripts): 
    NM_001144888.1  NM_006340.2  NM_017450.2  NM_017451.2  

    Unigene Cluster for BAIAP2:

    BAI1-associated protein 2
    Hs.128316  [show with all ESTs]
    Unigene Representative Sequence: AK127291
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000576470 ENST00000575750 ENST00000570913 ENST00000575989 ENST00000321280
    ENST00000572329(uc002jzb.2) ENST00000428708 ENST00000575712(uc002jyz.4 uc002jza.2 uc002jzc.2 uc010wui.2)
    ENST00000575245 ENST00000435091 ENST00000321300(uc002jzg.2 uc010wuh.1 uc002jzd.2 uc002jzf.2 uc002jze.2 uc002jzh.2)
    ENST00000573894 ENST00000571530 ENST00000573017 ENST00000572918 ENST00000575958
    ENST00000573659 ENST00000572073
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat BAIAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BAIAP2 (see all 50):
    hsa-miR-4272 hsa-miR-513a-5p hsa-miR-15a hsa-miR-485-3p hsa-miR-29a hsa-miR-3167 hsa-miR-1304 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidBAIAP2 3' UTR sequence
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for BAIAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): BAIAP2 (NM_017451)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BAIAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAIAP2
    Primer
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    OriGene qPCR primer pairs and template standards for BAIAP2
    OriGene qSTAR qPCR primer pairs in human, mouse for BAIAP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BAIAP2
      QuantiTect SYBR Green Assays in human, mouse, rat BAIAP2
      QuantiFast Probe-based Assays in human, mouse, rat BAIAP2

    Additional mRNA sequence: 

    AB015019.1 AB015020.1 AB017119.1 AB017120.1 AK023688.1 AK056888.1 AK127291.1 AK222670.1 
    AK225612.1 AK297644.1 AK298629.1 AK301436.1 BC002495.2 BC014020.2 BC032559.1 U70669.1 

    Selected DOTS entries (see all 30):

    DT.100885089  DT.106708  DT.92444973  DT.100885084  DT.75168840  DT.95226934  DT.100885080  DT.443448 
    DT.95226944  DT.75172568  DT.120937425  DT.92444964  DT.95226962  DT.100697561  DT.40246617  DT.97759993 
    DT.100803282  DT.120937354  DT.95132854  DT.120937357  DT.120937385  DT.40212091  DT.442429  DT.75140322 

    Selected AceView cDNA sequences (see all 341):

    BE252378 AA262334 AU122109 BC032559 BE778378 BQ432153 BQ651827 BQ428473 
    AL556018 U70669 BF447347 AI144006 BC002495 BQ710494 AW299831 BU159778 
    BI824231 BI753163 Z41362 AI093313 BM928074 NM_006340 CD674143 CB306187 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BAIAP2 (see all 23)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19a ·
    SP1:              -     -     -           -     -     -     -           -     -     -           -     -                                   -     -               
    SP2:                    -     -           -     -     -     -           -     -     -           -     -           -                       -     -               
    SP3:              -     -     -           -     -     -     -           -     -     -           -     -                                   -     -               
    SP4:              -     -     -           -     -     -     -           -     -     -           -     -                                   -     -               
    SP5:                                                                                                                                      -     -               

    ExUns: 19b · 19c ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b
    SP1:                                      -                       -                     
    SP2:                                      -                                             
    SP3:                                      -                                             
    SP4:                                      -                                             
    SP5:                                      -                       -                     


    ECgene alternative splicing isoforms for BAIAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    BAIAP2 expression in normal human tissues (normalized intensities)      BAIAP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCCTTGGG
    BAIAP2 Expression
    About this image


    BAIAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Eye (Sensory Organs)
             Lens Placode Cells Lens Placode
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    BAIAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BAIAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128316

    UniProtKB/Swiss-Prot: BAIP2_HUMAN, Q9UQB8
    Tissue specificity: Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely
    detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver,
    prostate, testis and placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BAIAP2: 
              Cytoskeleton Regulators in human mouse rat
              Adherens Junctions in human mouse rat
              Cell Motility in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BAIAP2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Baiap21 , 5 brain-specific angiogenesis inhibitor 1-associated more1, 5 87.82(n)1
    95.83(a)1
      11 (83.96 cM)5
    1081001  NM_001037755.31  NP_001032844.21 
     1199427635 
    chicken
    (Gallus gallus)
    Aves BAIAP21 BAI1-associated protein 2 81.62(n)
    86.21(a)
      422077  XM_420080.4  XP_420080.4 
    lizard
    (Anolis carolinensis)
    Reptilia BAIAP26
    BAI1-associated protein 2
    81(a)
    1 ↔ 1
    2(99526110-99618510)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.62992 Transcribed sequence with moderate similarity to protein more 75.35(n)    BX703765.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk29g022 Transcribed sequence with weak similarity to protein more 76.45(n)    BI980054.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG320826
    --
    13(a)
    1 → many
    3L(11129149-11157084)


    ENSEMBL Gene Tree for BAIAP2 (if available)
    TreeFam Gene Tree for BAIAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BAIAP2 gene
    BAIAP2L22  BAIAP2L12  
    2 SIMAP similar genes for BAIAP2 using alignment to 17 protein entries:     BAIP2_HUMAN (see all proteins):
    BAIAP2L2    BAIAP2L1

    BAIAP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BAIAP2 (see all 2460)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1908971311,2
    --74448352(+) GATCCA/CGCCCC 4 -- us2k10--------
    rs80732241,2
    C,H--74448765(+) GCGCCC/TGGGTC 4 -- int11Minor allele frequency- T:0.50NA 2
    rs116539781,2
    H--74448772(+) GGTcgC/Tgcgcc 4 -- int10--------
    rs597871721,2
    C--74452309(+) TTCCTC/GGGTGG 4 -- int11Minor allele frequency- G:0.00NA 2
    rs1119163461,2
    C--74457134(+) CCCTGC/-CTGAC 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs2013100981,2
    C--74461218(-) ACCCCC/TGTGTG 4 -- int10--------
    rs574682461,2
    C--74461790(+) AAAAA-/A/AA  
            
    GAATT
    4 -- int11NA 2
    rs2020856631,2
    --74471441(+) CCCCC-/CCGCCTGG 4 -- int10--------
    rs1403571711,2
    --74471446(+) CCGCC-/TGGTAGT 4 -- int10--------
    rs1438601151,2
    C--74477597(+) CTGCC-/CTTCTTCC 4 -- int10--------

    HapMap Linkage Disequilibrium report for BAIAP2 (79008947 - 79091232 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BAIAP2 (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716422CNV Deletion23290073
    esv2716424CNV Deletion23290073
    esv2716423CNV Deletion23290073
    esv2716421CNV Deletion23290073
    dgv3315n71CNV Loss21882294
    nsv828132CNV Loss20364138
    nsv909021CNV Loss21882294
    dgv3314n71CNV Loss21882294
    dgv3313n71CNV Loss21882294
    dgv3309n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BAIAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for BAIAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605475    OMIM disorders: --

    14 diseases for BAIAP2:    About MalaCards
    dentatorubral-pallidoluysian atrophy    wiskott-aldrich syndrome    attention deficit hyperactivity disorder    intrahepatic cholangiocarcinoma
    cholangiocarcinoma    cerebritis    neuronitis    ataxia
    tonsillitis    hiv-1    pancreatitis    thyroiditis
    prostatitis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for BAIAP2:
    dentatorubral-pallidoluysian atrophy

    BAIAP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for BAIAP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    drpla 81.5 11 10222779 (3), 10332026 (3), 11514062 (2), 12884081 (1)
    wiskott-aldrich syndrome 77.8 4 15673667 (1), 14752106 (1)
    neurodegenerative diseases 12.3 1 12884081 (1)

    Genetic Association Database (GAD): BAIAP2
    Human Genome Epidemiology (HuGE) Navigator: BAIAP2 (1 document)

    Export disorders for BAIAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BAIAP2 gene, integrated from 10 sources (see all 91):
    (articles sorted by number of sources associating them with BAIAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. (PubMed id 10343108)1, 2, 3, 9 Oda K.... Tokino T. (Cytogenet. Cell Genet. 1999)
    2. A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. (PubMed id 14752106)1, 2, 9 Yamagishi A.... Mochizuki N. (J. Biol. Chem. 2004)
    3. Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. (PubMed id 11696321)1, 2, 9 Krugmann S....Hall A. (Curr. Biol. 2001)
    4. IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation. (PubMed id 19286134)1, 2, 9 Weiss S.M.... Stradal T.E. (Cell Host Microbe 2009)
    5. Regulation of cell shape by Cdc42 is mediated by the synergic actin- bundling activity of the Eps8-IRSp53 complex. (PubMed id 17115031)1, 2, 9 Disanza A.... Scita G. (Nat. Cell Biol. 2006)
    6. Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53. (PubMed id 15635447)1, 2, 9 Millard T.H.... Fuetterer K. (EMBO J. 2005)
    7. Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate. (PubMed id 10332026)1, 2, 9 Okamura-Oho Y.... Yamada M. (Hum. Mol. Genet. 1999)
    8. Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein. (PubMed id 12884081)1, 2, 9 Miyahara A.... Yamada M. (J. Hum. Genet. 2003)
    9. Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder. (PubMed id 19733838)1, 4 RibasAcs M....Cormand B. (Biol. Psychiatry 2009)
    10. Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation. (PubMed id 19366662)1, 2 Vingadassalom D.... Leong J.M. (Proc. Natl. Acad. Sci. U.S.A. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10458 HGNC: 947 AceView: BAIAP2 Ensembl:ENSG00000175866 euGenes: HUgn10458
    ECgene: BAIAP2 Kegg: 10458 H-InvDB: BAIAP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BAIAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BAIAP2 gene:
    Search GeneIP for patents involving BAIAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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