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Aliases & Descriptions for BAI3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KIAA0550 1, 2, 3 | | MGC133100 2 | | OTTHUMP00000016691 2 |
| | | Descriptions |
|---|
| brain-specific angiogenesis inhibitor 3 2 | | dJ91B17.1 (brain-specific angiogenesis inhibitor 3) 2 |
|
| | Search outside databases for aliases for BAI3 genePrevious GC identifers: GC06P069305 GC06P069343 |
Summaries for BAI3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for BAI3: This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq] UniProtKB/Swiss-Prot: BAI3_HUMAN, O60242Function: Might be involved in angiogenesis inhibition and suppression of glioblastomaGene Wiki entry for BAI3 (Brain-specific_angiogenesis_inhibitor_3) |
Genomic Location for BAI3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the BAI3 gene 
Entrez Gene cytogenetic band: 6q12 Ensembl cytogenetic band: 6q12 HGNC cytogenetic band: 6q12BAI3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P069404:
(about GC identifiers)
Start:
|
69,401,980 bp from pter |
End:
|
70,156,124 bp from pter |
Size:
|
754,145 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007299.12
| Proteins for BAI3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: BAI3_HUMAN, O60242 (See
protein sequence)Recommended Name: Brain-specific angiogenesis inhibitor 3 precursor Size: 1522 amino acids; 171491 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: O60297 Q2NKN6 Q5VY37 Q9BX54Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001695.1
ENSEMBL proteins: ENSP00000238918 ENSP00000359630
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for BAI3: Assays for BAI3: | Protein
Domains/ Families for BAI3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O60242
ProtoNet protein and cluster: O60242 5/6 Blocks protein families (see all 6
): IPB000203 GPS domain IPB000832 G-protein coupled receptors family 2 (secretin-like) IPB000859 CUB domain IPB000884 Thrombospondin IPB008077 Brain-specific angiogenesis inhibitor precursor signature
UniProtKB/Swiss-Prot: BAI3_HUMAN, O60242Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamilySimilarity: Contains 1 CUB domainSimilarity: Contains 1 GPS domainSimilarity: Contains 4 TSP type-1 domains | Gene Function for BAI3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001704
Applied Biosystems Silencer® siRNAs for BAI3
Sigma-Aldrich siRNA and siRNA Panels for BAI3  Sigma-Aldrich shRNA Panels and shRNA for BAI3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001704                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001704                                  untagged cDNA clone in CMV expression vector: NM_001704 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001704
UniProtKB/Swiss-Prot: BAI3_HUMAN, O60242Function: Might be involved in angiogenesis inhibition and suppression of glioblastomaGenatlas biochemistry entry for BAI3:brain specific angiogenesis inhibitor 3,expressed in brain and heart,suppressor of glioblastoma family1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016527 | brain-specific angiogenesis inhibitor activity |
IEA | -- | About this table | Pathways & Interactions for BAI3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007218 | neuropeptide signaling pathway |
IEA | -- | About this table
|
Drugs & Compounds for BAI3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for BAI3
|
Transcripts for BAI3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001704
Sigma-Aldrich siRNA and siRNA Panels for BAI3  Sigma-Aldrich shRNA Panels and shRNA for BAI3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001704 REFSEQ mRNAs for BAI3 gene: NM_001704.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001704               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001704                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001704                                  untagged cDNA clone in CMV expression vector: NM_001704  Additional cDNA sequence: AB005299.1 AB011122.2 AK289696.1 AK293560.1 AK295516.1 AK316174.1 BC111720.1 CR600879.1 CR603474.1 5 DOTS entries: DT.455484 DT.95333180 DT.100735047 DT.100688933 DT.121311283 24/58 AceView cDNA sequences (see all 58
):BM693016 AI810109 Z45587 AB011122 NM_001704 AI701805 AB005299 F02127 CR603474 AI220034 BE467895 AL527820 CR600879 T33736 BI546847 AI018065 AU143757 N48913 AI989586 AL703782 BX492487 Z44579 BF223270 BX491995
highest scoring ESTs for BAI3:AB005299 AA813494 AB011122 AI220034 AI701805 AI810109 AI989586 AV701760 AW190248 AW954621 Unigene Cluster for BAI3: Brain-specific angiogenesis inhibitor 3 Hs.13261 [show with all ESTs]Unigene Representative Sequence: NM_001704
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000238918
ENST00000370598
|
Expression for BAI3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| BAI3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for BAI3
1 / 2 / 3 3 probe-sets matching BAI3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AAGCACAATG
SOURCE GeneReport for Unigene cluster: Hs.13261
Expression variation in blood from EXPOLDB for BAI3 UniProtKB/Swiss-Prot: BAI3_HUMAN, O60242Tissue specificity: Strongly expressed in brain. Also detected in heart. Reduced expression is observed in some glioblastoma cell lines |
Orthologs for BAI3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BAI3 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for BAI3
ENSEMBL Gene Tree for BAI3 | Paralogs for BAI3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for BAI3 gene
- BAI12 BAI22
|
SNPs/Variants for BAI3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for BAI3 (up to first 250kb)
|
Disorders & Mutations for BAI3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602684
Human Genome Epidemiology Navigator: BAI3 (1 document)
|
Medical News for BAI3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for BAI3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/11 PubMed articles for BAI3 gene (see all 11
):- Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PubMed id 9533023)1, 2, 3, 4 Shiratsuchi T.... Tokino T. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)3, 4 Nakajima D.... Nagase T. (2002)
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)3, 4 Nagase T....Ohara O. (1998)
- The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia. (PubMed id 18628273)1, 3 DeRosse P....Malhotra A.K. (2008)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)3 Trynka G....Wijmenga C. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- The human and mouse repertoire of the adhesion family of G-protein- coupled receptors. (PubMed id 15203201)3 Bjarnadottir T.K.... Schioeth H.B. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)4 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for BAI3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing BAI3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing BAI3
(According to HUGE)
About This Section
| |
Specialized Databases showing BAI3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for BAI3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for BAI3:

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