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BAI3 Gene

protein-coding   GIFtS: 60

GC06P069404
brain-specific angiogenesis inhibitor 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
KIAA0550 1, 2, 3
MGC133100 2
OTTHUMP00000016691 2
Descriptions
brain-specific angiogenesis inhibitor 3 2
dJ91B17.1 (brain-specific angiogenesis inhibitor 3) 2
External Ids
HGNC: 9451
Entrez Gene: 5772
UniProtKB: O602423
Ensembl: ENSG000001352987
Search outside databases for aliases for BAI3 gene

Previous GC identifers: GC06P069305 GC06P069343

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for BAI3:
This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane
protein, and is thought to be a member of the secretin receptor family. Brain-specific
angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue
specificities, and may also play a role in angiogenesis. [provided by RefSeq]

UniProtKB/Swiss-Prot: BAI3_HUMAN, O60242
Function: Might be involved in angiogenesis inhibition and suppression of glioblastoma

Gene Wiki entry for BAI3 (Brain-specific_angiogenesis_inhibitor_3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BAI3 gene  

Entrez Gene cytogenetic band: 6q12   Ensembl cytogenetic band:  6q12   HGNC cytogenetic band: 6q12

BAI3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P069404:     (about GC identifiers)

Start:
69,401,980 bp from pter
End:
70,156,124 bp from pter
Size:
754,145 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000006.10  NT_007299.12  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BAI3_HUMAN, O60242 (See protein sequence)
Recommended Name: Brain-specific angiogenesis inhibitor 3 precursor  
Size: 1522 amino acids; 171491 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: O60297 Q2NKN6 Q5VY37 Q9BX54

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001695.1  

    ENSEMBL proteins: 
    ENSP00000238918 ENSP00000359630 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (BAI3)
    Human Recombinant Proteins from Abnova (BAI3)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane TAS15203201
    About this table

    Antibodies for BAI3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for BAI3
    R&D Systems Antibodies for BAI3
    Antibodies from Abcam (BAI3), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (BAI3)
    Novus Biologicals Antibodies for BAI3

    Assays for BAI3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/8 InterPro domains/families (see all 8 ):
     IPR000859 CUB
     IPR000884 Thrombospondin_1_rpt
     IPR008077 GPCR_2_brain-spec_angio_inhib
     IPR017983 GPCR_2_secretin-like_CS
     IPR001879 GPCR_2_extracellular


       GeneDecks  BAI3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O60242

    ProtoNet protein and cluster: O60242

    5/6 Blocks protein families (see all 6 ):
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB000859 CUB domain
    IPB000884 Thrombospondin
    IPB008077 Brain-specific angiogenesis inhibitor precursor signature


    UniProtKB/Swiss-Prot: BAI3_HUMAN, O60242
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 1 CUB domain
    Similarity: Contains 1 GPS domain
    Similarity: Contains 4 TSP type-1 domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BAI3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BAI3)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001704

                  Applied Biosystems Silencer® siRNAs for BAI3

                  Sigma-Aldrich siRNA and siRNA Panels for BAI3  
                         Sigma-Aldrich shRNA Panels and shRNA for BAI3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001704
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001704
                                     untagged cDNA clone in CMV expression vector: NM_001704 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001704

    UniProtKB/Swiss-Prot: BAI3_HUMAN, O60242
    Function: Might be involved in angiogenesis inhibition and suppression of glioblastoma

    Genatlas biochemistry entry for BAI3:
    brain specific angiogenesis inhibitor 3,expressed in brain and heart,suppressor of glioblastoma
    family

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016527 brain-specific angiogenesis inhibitor activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for BAI3 (Maps provided by GeneGo):
     G12a specific GPCRs (in brain)

       GeneDecks  BAI3 for the pathways selected above  
    About GeneDecksing

      --

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007218 neuropeptide signaling pathway IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for BAI3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BAI3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BAI3)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001704

                  Sigma-Aldrich siRNA and siRNA Panels for BAI3  
                         Sigma-Aldrich shRNA Panels and shRNA for BAI3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001704  

    REFSEQ mRNAs for BAI3 gene: 

    NM_001704.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001704  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001704
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001704
                                     untagged cDNA clone in CMV expression vector: NM_001704 

    Additional cDNA sequence: 

    AB005299.1 AB011122.2 AK289696.1 AK293560.1 AK295516.1 AK316174.1 BC111720.1 CR600879.1 
    CR603474.1 

    5 DOTS entries:

    DT.455484  DT.95333180  DT.100735047  DT.100688933  DT.121311283 

    24/58 AceView cDNA sequences (see all 58 ):

    BM693016 AI810109 Z45587 AB011122 NM_001704 AI701805 AB005299 F02127 
    CR603474 AI220034 BE467895 AL527820 CR600879 T33736 BI546847 AI018065 
    AU143757 N48913 AI989586 AL703782 BX492487 Z44579 BF223270 BX491995 

    highest scoring ESTs for BAI3:

    AB005299 AA813494 AB011122 AI220034 AI701805 AI810109 AI989586 AV701760 AW190248 AW954621 

    Unigene Cluster for BAI3:

    Brain-specific angiogenesis inhibitor 3
    Hs.13261  [show with all ESTs]
    Unigene Representative Sequence: NM_001704


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000238918  ENST00000370598  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    BAI3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for BAI3

    1 / 2 / 3

    3 probe-sets matching BAI3 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40664_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB005299 1.00 1.00 1.00 1

    205638_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001704 0.60 1.00 0.82 1

    205638_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  BAI3 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AAGCACAATG

    SOURCE GeneReport for Unigene cluster: Hs.13261

    Expression variation in blood from EXPOLDB for BAI3

    UniProtKB/Swiss-Prot: BAI3_HUMAN, O60242
    Tissue specificity: Strongly expressed in brain. Also detected in heart. Reduced expression is
    observed in some glioblastoma cell lines

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for BAI3 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    BAI31   -- brain-specific angiogenesis inhibitor 3 95.93(n)
    98.55(a)
    481870  XM_538991.2  XP_538991.2 
    cow
    (Bos taurus)
    BAI31   -- brain-specific angiogenesis inhibitor 3 90.84(n)
    95.33(a)
    519556  XM_597779.3  XP_597779.3 
    rat
    (Rattus norvegicus)
    Bai31   -- brain-specific angiogenesis inhibitor 3 91.79(n)
    98.03(a)
    301309  XM_217367.4  XP_217367.3 
    mouse
    (Mus musculus)
    Bai31, 5 15
    brain-specific angiogenesis inhibitor 31, 5 92.27(n)1
    98.29(a)1
    2109331  NM_175642.31  NP_783573.31 
     AK0340155  AK0441605  (see all 13)
    chicken
    (Gallus gallus)
    BAI31   -- brain-specific angiogenesis inhibitor 3 88.09(n)
    94.93(a)
    421875  XM_419892.2  XP_419892.2 
    About this table        Species with no ortholog for BAI3

    ENSEMBL Gene Tree for BAI3
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for BAI3 gene
    BAI12  BAI22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/3673 NCBI SNPs in BAI3 are shown (see all 3673 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 1342)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs19326181,2
    A,C,F,H69723405(+) ATGCAG/ATGAGC 1 N/S mis117Minor allele frequency- A:0.09EA NA EU WA 2912
    rs21830711,2
    H70128123(-) CACCTC/GTAAAG 1 E/Q mis14Minor allele frequency- G:0.00EU EA WA 418
    rs9135431,2
    A,C,F,H,O70127894(+) TTGCCA/GCATGA 1 P/P syn1 ese312Minor allele frequency- G:0.28NA EA MN EU WA 2463
    rs22969741,2
    C,F,H,O70120908(-) GAACTC/TGAAGA 1 S/S syn112Minor allele frequency- T:0.14EU EA WA 1258
    rs13842481,2
    A,C,F,H,O69866472(+) GCTTAG/ATGCCA 1 -- int18Minor allele frequency- A:0.25EA NA EU WA 2024
    rs4988011,2
    A,C,F,H,O69594705(+) ATTCAC/TTGTTT 1 -- int112Minor allele frequency- T:0.23EU EA WA NA 1044
    rs7282991,2
    A,C,F,H,O70014850(+) TCATGT/ATGGAG 1 -- int19Minor allele frequency- A:0.10NA EU EA WA 734
    rs9513991,2
    A,C,F,H,O69661469(+) GCTATA/GTGAAT 1 -- int112Minor allele frequency- G:0.45EU EA WA NA 1034
    rs25856271,2
    A,C,F,H,O69414352(-) TAGTCG/AGAAAT 1 -- int17Minor allele frequency- A:0.49NA EU EA WA 560
    rs14823241,2
    A,C,F,H,O69853942(+) ATAATC/TCAAAC 1 -- int111Minor allele frequency- T:0.49EU EA WA NA 980
    About this table

    HapMap Linkage Disequilibrium images for BAI3 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 602684

    Human Genome Epidemiology Navigator: BAI3 (1 document)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/11 PubMed articles for BAI3 gene (see all 11 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 577 HGNC: 945 AceView: BAI3 Ensembl:ENSG00000135298 euGenes: HUgn577
    ECgene: BAI3 H-InvDB: BAI3
    (According to HUGE)
    About This Section

    HUGE: KIAA0550
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for BAI3 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for BAI3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for BAI3 Antibodies for BAI3
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for BAI3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search OriGene for BAI3
     Search Tocris compounds for BAI3




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for BAI3

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