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BAI2 Gene

protein-coding   GIFtS: 60

GC01M032000
brain-specific angiogenesis inhibitor 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Descriptions
Brain-specific angiongenesis inhibitor-2 2
brain-specific angiogenesis inhibitor 2 2
External Ids
HGNC: 9441
Entrez Gene: 5762
UniProtKB: O602413
Ensembl: ENSG000001217537
Search outside databases for aliases for BAI2 gene

Previous GC identifers: GC01M031177 GC01M031619 GC01M031695 GC01M031861

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BAI2:
BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane
protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis
proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may
also play a role in angiogenesis. [provided by RefSeq]

UniProtKB/Swiss-Prot: BAI2_HUMAN, O60241
Function: Might be involved in angiogenesis inhibition

Gene Wiki entry for BAI2 (Brain-specific_angiogenesis_inhibitor_2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BAI2 gene  

Entrez Gene cytogenetic band: 1p35   Ensembl cytogenetic band:  1p35.2   HGNC cytogenetic band: 1p35

BAI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M032000:     (about GC identifiers)

Start:
31,965,305 bp from pter
End:
32,002,528 bp from pter
Size:
37,224 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_032977.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BAI2_HUMAN, O60241 (See protein sequence)
Recommended Name: Brain-specific angiogenesis inhibitor 2 precursor  
Size: 1585 amino acids; 172656 Da
Subunit: Interacts with GABPB2 (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=CAI16890.1; Type=Erroneous gene model prediction;
Secondary accessions: B9EGK9 Q5T6K0 Q8NGW8 Q96GZ9
Alternative splicing: 4 isoforms:  O60241-1   O60241-2   O60241-3   O60241-4   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001694.2  

    ENSEMBL proteins: 
    ENSP00000381550 ENSP00000381548 ENSP00000381555 ENSP00000257070 ENSP00000362759 ENSP00000362762 
    ENSP00000381564 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins and CompoZr ZFN for BAI2  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (BAI2)
    Human Recombinant Proteins from Abnova (BAI2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane TAS15203201
    About this table

    Antibodies for BAI2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for BAI2
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (BAI2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (BAI2)
    Novus Biologicals Antibodies for BAI2

    Assays for BAI2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/7 InterPro domains/families (see all 7 ):
     IPR000884 Thrombospondin_1_rpt
     IPR008077 GPCR_2_brain-spec_angio_inhib
     IPR017983 GPCR_2_secretin-like_CS
     IPR001879 GPCR_2_extracellular
     IPR017981 GPCR_2-like


       GeneDecks  BAI2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O60241

    ProtoNet protein and cluster: O60241

    5 Blocks protein families:
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB000884 Thrombospondin
    IPB008077 Brain-specific angiogenesis inhibitor precursor signature
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: BAI2_HUMAN, O60241
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 1 GPS domain
    Similarity: Contains 4 TSP type-1 domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BAI2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BAI2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001703

                  Applied Biosystems Silencer® siRNAs for BAI2

                  Sigma-Aldrich siRNA and siRNA Panels for BAI2  
                         Sigma-Aldrich shRNA Panels and shRNA for BAI2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001703
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001703
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001703 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001703

    UniProtKB/Swiss-Prot: BAI2_HUMAN, O60241
    Function: Might be involved in angiogenesis inhibition

    Genatlas biochemistry entry for BAI2:
    brain specific angiogenesis inhibitor 2,expressed in brain,thymus,skeletal muscle and
    heart,suppressor of glioblastoma family

    1 MGI mutant phenotype (inferred from 1 allele(MGI details for Bai2):

    behavior/neurological

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016527 brain-specific angiogenesis inhibitor activity TAS12218411
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for BAI2 (Maps provided by GeneGo):
     G12a specific GPCRs (in brain)

       GeneDecks  BAI2 for the pathways selected above  
    About GeneDecksing


    2 Interacting proteins for BAI2 (O602412 ENSP000003627593) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABPB1Q065472, ENSP000003702593MINT-75010 STRING (score=.729)
    SHANK1Q9Y5662MINT-72957
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007218 neuropeptide signaling pathway IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Sigma-Aldrich Small Molecules for BAI2:
    Antagonist Inhibitor

    Browse Tocris compounds for BAI2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BAI2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BAI2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001703

                  Sigma-Aldrich siRNA and siRNA Panels for BAI2  
                         Sigma-Aldrich shRNA Panels and shRNA for BAI2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001703  

    REFSEQ mRNAs for BAI2 gene: 

    NM_001703.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001703  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001703
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001703
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001703 

    Additional cDNA sequence: 

    AB005298.1 AK294361.1 AK294999.1 AK296502.1 AK307805.1 BC009035.1 BC014780.1 BC136533.1 
    CR602649.1 CR623649.1 

    9 DOTS entries:

    DT.444900  DT.121430675  DT.75140258  DT.40131864  DT.97773219  DT.121430665  DT.121430670  DT.40215398 
    DT.97825489 

    24/86 AceView cDNA sequences (see all 86 ):

    AL119903 Z38584 AL138021 CR623649 BU850096 AL536849 AL532596 BM466505 
    CR602649 T03536 BM669059 AU124468 BE379230 NM_001703 AB005298 BC009035 
    F03924 BI757068 BF346234 BG403377 BI825201 BI752810 BM765444 AK123392 

    highest scoring ESTs for BAI2:

    AB005298 AA363909 AA452869 AA593743 AA777034 AA836906 AA853071 AA853074 AA984119 AI073861 

    Unigene Cluster for BAI2:

    Brain-specific angiogenesis inhibitor 2
    Hs.524138  [show with all ESTs]
    Unigene Representative Sequence: NM_001703


    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for BAI2 (see all 16 )

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:        -                                                                                                                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32 ^ 33 ^ 34a · 34b ^ 35a · 35b
    SP1:        -           -                                         -     -           -                                                           -               
    SP2:                                                              -     -     -     -                                                                           
    SP3:                                                              -     -     -     -                                                                           
    SP4:        -           -     -     -                                                                                                                           
    SP5:                                                                                                                                                            

    About this scheme

    ECgene alternative splicing isoforms for BAI2

    7 Ensembl transcripts including schematic representations:
    ENST00000398542  ENST00000398538  ENST00000398547  ENST00000257070  ENST00000373655  ENST00000373658  
    ENST00000398556  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    BAI2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for BAI2

    1 / 2 / 3

    3 probe-sets matching BAI2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33785_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB005298 1.00 1.00 1.00 1

    204966_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001703 0.60 1.00 0.82 1

    204966_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  BAI2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCTTGGCCTG

    SOURCE GeneReport for Unigene cluster: Hs.524138

    Expression variation in blood from EXPOLDB for BAI2

    UniProtKB/Swiss-Prot: BAI2_HUMAN, O60241
    Tissue specificity: Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle,
    and different cell lines

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for BAI2 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    BAI21   -- brain-specific angiogenesis inhibitor 2 92.89(n)
    97.45(a)
    487317  XM_544443.2  XP_544443.2 
    chimpanzee
    (Pan troglodytes)
    BAI21   -- brain-specific angiogenesis inhibitor 2 99.41(n)
    99.55(a)
    456703  XM_513271.2  XP_513271.2 
    rat
    (Rattus norvegicus)
    Bai21   -- brain-specific angiogenesis inhibitor 2 90.45(n)
    96.24(a)
    313058  XM_232778.4  XP_232778.4 
    mouse
    (Mus musculus)
    Bai21, 5 45
    brain-specific angiogenesis inhibitor 21, 5 91.31(n)1
    96.91(a)1
    2307751  NM_173071.11  NP_775094.11 
     AI4154425  AI8487195  (see all 15)
    zebrafish
    (Danio rerio)
    si:ch211-149a22.11   -- si:ch211-149a22.1 66.86(n)
    67.64(a)
    556993  XM_679947.3  XP_685039.3 
    About this table        Species with no ortholog for BAI2

    ENSEMBL Gene Tree for BAI2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for BAI2 gene
    BAI12  BAI32  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/144 NCBI SNPs in BAI2 are shown (see all 144 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 58)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs75430901,2
    A,C,F,H32003742(+) TTGTGG/TCACCC 1 -- ng314Minor allele frequency- T:0.10EU EA WA 410
    rs38062501,2
    H32003523(-) CCTACT/CTGTGT 1 -- ng314Minor allele frequency- C:0.00EU EA WA 418
    --
    rs10431631,2
    C31965554(-) TTTCAC/AACTCC 1 -- ut31 ese31Minor allele frequency- A:0.00MN 184
    rs109144731,2
    C,H31969476(+) AGGCAG/ATGGTG 1 L/L syn1 ese34Minor allele frequency- A:0.00EU EA WA 416
    --
    rs9090011,2
    A31969234(+) CCCTCC/GGGCCG 1 P/P syn1 ese30--------
    --
    rs11271001,2
    C31966234(-) GGGGCA/GGCCGA 1 A/A syn10--------
    rs20502561,2
    A,C,F,H,O31977270(+) ACTTCA/GGGTGA 1 -- int18Minor allele frequency- G:0.25MN EU EA WA NA 738
    rs107988881,2
    A,C,F,H31971686(+) GGGCCG/TGGACG 1 -- int14Minor allele frequency- T:0.34EU EA WA 410
    rs120370191,2
    A,C,F,H31986242(+) CCAAAT/CGCGGA 1 -- int111Minor allele frequency- C:0.16NA EU EA WA 954
    rs49492221,2
    A,C,F,H31993502(+) GGCTCG/TCAGAG 1 -- int14Minor allele frequency- T:0.11EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for BAI2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 602683

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/14 PubMed articles for BAI2 gene (see all 14 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 576 HGNC: 944 AceView: BAI2 Ensembl:ENSG00000121753 euGenes: HUgn576
    ECgene: BAI2 H-InvDB: BAI2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for BAI2 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for BAI2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for BAI2 Antibodies for BAI2
     Explore super-pooled esiRNAs Proteins for BAI2
     Lentivirus-delivered shRNAs for BAI2 Small molecules for BAI2
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     Antibodies for BAI2

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