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BAI2 Gene

protein-coding   GIFtS: 61
GCID: GC01M032192

Brain-Specific Angiogenesis Inhibitor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Brain-Specific Angiogenesis Inhibitor 21 2
Brain-Specific Angiongenesis Inhibitor-22

External Ids:    HGNC: 9441   Entrez Gene: 5762   Ensembl: ENSG000001217537   OMIM: 6026835   UniProtKB: O602413   

Export aliases for BAI2 gene to outside databases

Previous GC identifers: GC01M032000 GC01M031177 GC01M031619 GC01M031695 GC01M031861 GC01M031965 GC01M030310


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BAI2 Gene:
BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is
thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are
similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.
(provided by RefSeq, Jul 2008)

GeneCards Summary for BAI2 Gene:
BAI2 (brain-specific angiogenesis inhibitor 2) is a protein-coding gene. Diseases associated with BAI2 include narcolepsy, and ischemia. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is UNC5B.

UniProtKB/Swiss-Prot: BAI2_HUMAN, O60241
Function: Might be involved in angiogenesis inhibition

Gene Wiki entry for BAI2 (Brain-specific angiogenesis inhibitor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BAI2 gene promoter:
         E2F-4   E2F-3a   E2F-5   NRSF form 1   E2F-2   NRSF form 2   HEN1   E2F   E2F-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBAI2 promoter sequence
   Search Chromatin IP Primers for BAI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BAI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35   Ensembl cytogenetic band:  1p35.2   HGNC cytogenetic band: 1p35

BAI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAI2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M032192:  view genomic region     (about GC identifiers)

Start:
32,192,718 bp from pter      End:
32,230,494 bp from pter
Size:
37,777 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BAI2_HUMAN, O60241 (See protein sequence)
Recommended Name: Brain-specific angiogenesis inhibitor 2 precursor  
Size: 1585 amino acids; 172656 Da
Subunit: Interacts with GABPB2 (By similarity)
Sequence caution: Sequence=BAA25362.1; Type=Erroneous initiation; Sequence=CAI16890.1; Type=Erroneous gene model
prediction;
Secondary accessions: B9EGK9 Q5T6K0 Q8NGW8 Q96GZ9
Alternative splicing: 4 isoforms:  O60241-1   O60241-2   O60241-3   O60241-4   

Explore the universe of human proteins at neXtProt for BAI2: NX_O60241

Explore proteomics data for BAI2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn106, Asn191, Asn192, Asn356, Asn437, Asn560, Asn645, Asn867
  • Modification sites at PhosphoSitePlus

  • See BAI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001694.2  
    ENSEMBL proteins: 
     ENSP00000381564   ENSP00000381555   ENSP00000362759   ENSP00000362762   ENSP00000381550  
     ENSP00000435397   ENSP00000381548   ENSP00000410921   ENSP00000437219   ENSP00000414758  
     ENSP00000257070   ENSP00000391071  

    BAI2 Human Recombinant Protein Products:

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    Novus Biologicals BAI2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BAI2

    BAI2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BAI2
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    Abcam antibodies for BAI2
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    ThermoFisher Antibodies for BAI2
    LSBio Antibodies in human, mouse, rat for BAI2

    BAI2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BAI2
    Cloud-Clone Corp. CLIAs for BAI2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRBO: GPCR / Class B : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: BAI2
    Adhesion Class GPCRs

    Selected InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR001879 GPCR_2_extracellular_dom
     IPR000832 GPCR_2_secretin-like
     IPR008077 GPCR_2_brain-spec_angio_inhib
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry O60241

    ProtoNet protein and cluster: O60241

    5 Blocks protein domains:
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB000884 Thrombospondin
    IPB008077 Brain-specific angiogenesis inhibitor precursor signature
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: BAI2_HUMAN, O60241
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 1 GPS domain
    Similarity: Contains 4 TSP type-1 domains


    BAI2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BAI2_HUMAN, O60241
    Function: Might be involved in angiogenesis inhibition

         Genatlas biochemistry entry for BAI2:
    brain specific angiogenesis inhibitor 2,expressed in brain,thymus,skeletal muscle and heart,suppressor of
    glioblastoma family

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding ----
         
    BAI2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BAI2:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Bai2):
     behavior/neurological 

    BAI2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BAI2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BAI2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BAI2

    miRNA
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    miRTarBase miRNAs that target BAI2:
    hsa-mir-324-5p (MIRT043178)

    Block miRNA regulation of human, mouse, rat BAI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BAI2 (see all 11):
    hsa-miR-194* hsa-miR-3938 hsa-miR-4251 hsa-miR-122 hsa-miR-3065-5p hsa-miR-759 hsa-miR-3647-3p hsa-miR-2355-5p
    SwitchGear 3'UTR luciferase reporter plasmidBAI2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BAI2
    Predesigned siRNA for gene silencing in human, mouse, rat BAI2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for BAI2

    Clone
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    OriGene clones in human, mouse for BAI2 (see all 6)
    OriGene ORF clones in mouse, rat for BAI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BAI2 (NM_001703)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BAI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAI2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for BAI2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAI2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BAI2_HUMAN, O60241: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    BAI2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including BAI2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for BAI2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for BAI2 (O602412, 3 ENSP000003627624) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABPB1Q065472, 3, ENSP000003702594MINT-75010 I2D: score=2 STRING: ENSP00000370259
    SHANK1Q9Y5662, 3, ENSP000002934414MINT-72957 I2D: score=3 STRING: ENSP00000293441
    STARD13Q9Y3M83, ENSP000003387854I2D: score=5 STRING: ENSP00000338785
    ARHGAP1Q079603, ENSP000003104914I2D: score=1 STRING: ENSP00000310491
    HDHD2Q9H0R43, ENSP000003006054I2D: score=1 STRING: ENSP00000300605
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS15203201
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0007422peripheral nervous system development IEA--
    GO:0016525negative regulation of angiogenesis IEA--

    BAI2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BAI2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BAI2 gene: 
    NM_001703.2  

    Unigene Cluster for BAI2:

    Brain-specific angiogenesis inhibitor 2
    Hs.524138  [show with all ESTs]
    Unigene Representative Sequence: NM_001703
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000465239 ENST00000398556(uc010ogn.2) ENST00000398547(uc010ogo.2 uc010ogr.1)
    ENST00000373655(uc010ogq.2 uc001bto.3) ENST00000373658(uc010ogp.2 uc001btn.3)
    ENST00000398542(uc001btq.1) ENST00000465256(uc001btp.1) ENST00000530999
    ENST00000525655 ENST00000527361 ENST00000398538 ENST00000484002 ENST00000466109
    ENST00000420125 ENST00000530134 ENST00000533175 ENST00000468430 ENST00000473952

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BAI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BAI2 (see all 11):
    hsa-miR-194* hsa-miR-3938 hsa-miR-4251 hsa-miR-122 hsa-miR-3065-5p hsa-miR-759 hsa-miR-3647-3p hsa-miR-2355-5p
    SwitchGear 3'UTR luciferase reporter plasmidBAI2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BAI2
    Predesigned siRNA for gene silencing in human, mouse, rat BAI2
    Clone
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    OriGene clones in human, mouse for BAI2 (see all 6)
    OriGene ORF clones in mouse, rat for BAI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BAI2 (NM_001703)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BAI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAI2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for BAI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BAI2
      QuantiTect SYBR Green Assays in human, mouse, rat BAI2
      QuantiFast Probe-based Assays in human, mouse, rat BAI2

    Additional mRNA sequence: 

    AB005298.1 AK294361.1 AK294999.1 AK296502.1 AK307805.1 BC009035.1 BC014780.1 BC136533.1 

    9 DOTS entries:

    DT.444900  DT.121430675  DT.75140258  DT.40131864  DT.121430665  DT.121430670  DT.97773219  DT.40215398 
    DT.97825489 

    Selected AceView cDNA sequences (see all 86):

    BC009035 T03536 F03924 CR623649 AL138021 AU124468 AL532596 BU850096 
    CR602649 NM_001703 AL536849 BM669059 AB005298 AL119903 Z38584 BM466505 
    BE379230 AI674773 BE878825 BC014780 AL118959 BI755088 AI360352 BF346234 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BAI2 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:        -                                                                                                                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32 ^ 33 ^ 34a · 34b ^ 35a · 35b
    SP1:        -           -                                         -     -           -                                                           -               
    SP2:                                                              -     -     -     -                                                                           
    SP3:                                                              -     -     -     -                                                                           
    SP4:        -           -     -     -                                                                                                                           
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for BAI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BAI2 expression in normal human tissues (normalized intensities)      BAI2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTGGCCTG
    BAI2 Expression
    About this image


    BAI2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
    BAI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BAI2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524138

    UniProtKB/Swiss-Prot: BAI2_HUMAN, O60241
    Tissue specificity: Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different
    cell lines

        Pathway & Disease-focused RT2 Profiler PCR Array including BAI2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for BAI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BAI2
    QuantiTect SYBR Green Assays in human, mouse, rat BAI2
    QuantiFast Probe-based Assays in human, mouse, rat BAI2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BAI2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bai21 , 5 brain-specific angiogenesis inhibitor 21, 5 89.95(n)1
    95.27(a)1
      4 (63.43 cM)5
    2307751  NM_173071.31  NP_775094.21 
     1299848705 
    chicken
    (Gallus gallus)
    Aves BAI21 brain-specific angiogenesis inhibitor 2 75.17(n)
    75.2(a)
      426163  XM_423828.4  XP_423828.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    69(a)
    62(a)
    1 ↔ many
    1 ↔ many
    GL343308.1(723206-860830)
    GL343308.1(705802-719362)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bai21 brain-specific angiogenesis inhibitor 2 67.09(n)
    69.53(a)
      100498218  XM_002938488.2  XP_002938534.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BAI26
    brain-specific angiogenesis inhibitor 2
    61(a)
    1 ↔ 1
    19(40494453-40675829) ENSDARG00000088161
    fruit fly
    (Drosophila melanogaster)
    Insecta unc-56
    unc-5
    15(a)
    1 → many
    2R(11237659-11255807)
    worm
    (Caenorhabditis elegans)
    Secernentea T21B6.36
    Protein T21B6.3 (T21B6.3) mRNA, complete cds
    16(a)
    many ↔ many
    X(10945154-10948970) WBGene00011880


    ENSEMBL Gene Tree for BAI2 (if available)
    TreeFam Gene Tree for BAI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BAI2 gene
    UNC5B2  BAI12  UNC5C2  UNC5A2  UNC5CL2  CFP2  BAI32  UNC5D2  
    4 SIMAP similar genes for BAI2 using alignment to 8 protein entries:     BAI2_HUMAN (see all proteins):
    BAI3    FLJ00046    BAI1    ELTD1

    BAI2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BAI2 (see all 823)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818181631,2
    --30348735(+) GGGAAG/TGGGGT 1 -- us2k10--------
    rs2009495821,2
    C--30348767(+) GAGGT-/GGCAAA 1 -- us2k10--------
    rs1868485531,2
    --30348839(+) AGGACC/GCTGTC 1 -- us2k10--------
    rs785694671,2
    F--30348958(+) TGTGAT/CGCAGC 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs2021890391,2
    --30348976(+) TGAGG-/CCCCCC 1 -- us2k10--------
    rs1409766271,2
    --32192232(+) CCACAA/TGGTCA 1 -- ds50010--------
    rs585110511,2
    C,F--32192543(+) CCAGAA/C/GAGTCA 1 -- ds50013WA 122
    rs1821849551,2
    --32192692(+) CCTGAC/GGGAAG 1 -- ds50010--------
    rs1449247131,2
    C--32192758(+) CTCCCC/GCCTCC 1 -- ut310--------
    rs1864253551,2
    --32192781(+) AGGGAC/TGGACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for BAI2 (32192718 - 32230494 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BAI2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv209n71CNV Loss21882294
    dgv210n71CNV Loss21882294
    nsv461028CNV Loss19166990
    dgv46e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BAI2
    DNA2.0 Custom Variant and Variant Library Synthesis for BAI2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602683    OMIM disorders: --

    2 diseases for BAI2:    About MalaCards
    narcolepsy    ischemia


    BAI2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BAI2
    Human Genome Epidemiology (HuGE) Navigator: BAI2 (1 document)

    Export disorders for BAI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BAI2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with BAI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PubMed id 9533023)1, 2, 3, 9 Shiratsuchi T.... Tokino T. (Cytogenet. Cell Genet. 1997)
    2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor. (PubMed id 16412436)1, 9 Jeong B.C....Kim K.K. (FEBS Lett. 2006)
    5. Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein. (PubMed id 21787750)1 Zencir S....Mohanty S. (Biochem. Biophys. Res. Commun. 2011)
    6. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. (PubMed id 20367554)1 Okajima D....Yokota H. (J. Recept. Signal Transduct. Res. 2010)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    9. Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. (PubMed id 14697242)1 Nagaraja G.M. and Kandpal R.P. (Biochem. Biophys. Res. Commun. 2004)
    10. The human and mouse repertoire of the adhesion family of G-protein- coupled receptors. (PubMed id 15203201)1 Bjarnadottir T.K.... Schioeth H.B. (Genomics 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 576 HGNC: 944 AceView: BAI2 Ensembl:ENSG00000121753 euGenes: HUgn576
    ECgene: BAI2 H-InvDB: BAI2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BAI2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BAI2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BAI2 gene:
    Search GeneIP for patents involving BAI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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