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Aliases & Descriptions for BAI2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Brain-specific angiongenesis inhibitor-2 2 | | brain-specific angiogenesis inhibitor 2 2 |
|
| | Search outside databases for aliases for BAI2 genePrevious GC identifers: GC01M031177 GC01M031619 GC01M031695 GC01M031861 |
Summaries for BAI2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for BAI2: BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis. [provided by RefSeq] UniProtKB/Swiss-Prot: BAI2_HUMAN, O60241Function: Might be involved in angiogenesis inhibitionGene Wiki entry for BAI2 (Brain-specific_angiogenesis_inhibitor_2) |
Genomic Location for BAI2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the BAI2 gene 
Entrez Gene cytogenetic band: 1p35 Ensembl cytogenetic band: 1p35.2 HGNC cytogenetic band: 1p35BAI2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M032000:
(about GC identifiers)
Start:
|
31,965,305 bp from pter |
End:
|
32,002,528 bp from pter |
Size:
|
37,224 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_032977.8
| Proteins for BAI2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: BAI2_HUMAN, O60241 (See
protein sequence)Recommended Name: Brain-specific angiogenesis inhibitor 2 precursor Size: 1585 amino acids; 172656 Da
Subunit: Interacts with GABPB2 (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=CAI16890.1; Type=Erroneous gene model prediction;
Secondary accessions: B9EGK9 Q5T6K0 Q8NGW8 Q96GZ9Alternative splicing: 4 isoforms: O60241-1 O60241-2 O60241-3 O60241-4 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001694.2
ENSEMBL proteins: ENSP00000381550 ENSP00000381548 ENSP00000381555 ENSP00000257070 ENSP00000362759 ENSP00000362762 ENSP00000381564
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for BAI2: Assays for BAI2: | Protein
Domains/ Families for BAI2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O60241
ProtoNet protein and cluster: O60241 5 Blocks protein families: IPB000203 GPS domain IPB000832 G-protein coupled receptors family 2 (secretin-like) IPB000884 Thrombospondin IPB008077 Brain-specific angiogenesis inhibitor precursor signature IPB008085 Thrombospondin type 1 repeat signature
UniProtKB/Swiss-Prot: BAI2_HUMAN, O60241Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamilySimilarity: Contains 1 GPS domainSimilarity: Contains 4 TSP type-1 domains | Gene Function for BAI2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001703
Applied Biosystems Silencer® siRNAs for BAI2
Sigma-Aldrich siRNA and siRNA Panels for BAI2  Sigma-Aldrich shRNA Panels and shRNA for BAI2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001703                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001703                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001703 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001703
UniProtKB/Swiss-Prot: BAI2_HUMAN, O60241Function: Might be involved in angiogenesis inhibitionGenatlas biochemistry entry for BAI2:brain specific angiogenesis inhibitor 2,expressed in brain,thymus,skeletal muscle and heart,suppressor of glioblastoma family1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Bai2):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016527 | brain-specific angiogenesis inhibitor activity |
TAS | 12218411 | About this table | Pathways & Interactions for BAI2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Interacting proteins for BAI2 (O602412 ENSP000003627593) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007218 | neuropeptide signaling pathway |
IEA | -- | About this table
|
Drugs & Compounds for BAI2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for BAI2
|
Transcripts for BAI2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001703
Sigma-Aldrich siRNA and siRNA Panels for BAI2  Sigma-Aldrich shRNA Panels and shRNA for BAI2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001703 REFSEQ mRNAs for BAI2 gene: NM_001703.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001703               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001703                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001703                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001703  Additional cDNA sequence: AB005298.1 AK294361.1 AK294999.1 AK296502.1 AK307805.1 BC009035.1 BC014780.1 BC136533.1 CR602649.1 CR623649.1 9 DOTS entries: DT.444900 DT.121430675 DT.75140258 DT.40131864 DT.97773219 DT.121430665 DT.121430670 DT.40215398 DT.97825489 24/86 AceView cDNA sequences (see all 86
):AL119903 Z38584 AL138021 CR623649 BU850096 AL536849 AL532596 BM466505 CR602649 T03536 BM669059 AU124468 BE379230 NM_001703 AB005298 BC009035 F03924 BI757068 BF346234 BG403377 BI825201 BI752810 BM765444 AK123392
highest scoring ESTs for BAI2:AB005298 AA363909 AA452869 AA593743 AA777034 AA836906 AA853071 AA853074 AA984119 AI073861 Unigene Cluster for BAI2: Brain-specific angiogenesis inhibitor 2 Hs.524138 [show with all ESTs]Unigene Representative Sequence: NM_001703
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for BAI2 (see all 16
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | |
| SP1: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 21 | ^ | 22a | · | 22b | · | 22c | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | ^ | 27a | · | 27b | ^ | 28a | · | 28b | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b | · | 31c | ^ | 32 | ^ | 33 | ^ | 34a | · | 34b | ^ | 35a | · | 35b | |
| SP1: | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for BAI2
7 Ensembl transcripts including schematic representations: ENST00000398542
ENST00000398538
ENST00000398547
ENST00000257070
ENST00000373655
ENST00000373658
ENST00000398556
|
Expression for BAI2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| BAI2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for BAI2
1 / 2 / 3 3 probe-sets matching BAI2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCTTGGCCTG
SOURCE GeneReport for Unigene cluster: Hs.524138
Expression variation in blood from EXPOLDB for BAI2 UniProtKB/Swiss-Prot: BAI2_HUMAN, O60241Tissue specificity: Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines |
Orthologs for BAI2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BAI2 gene from 5 species
About this table Species with no ortholog for BAI2
ENSEMBL Gene Tree for BAI2 | Paralogs for BAI2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for BAI2 gene
- BAI12 BAI32
|
SNPs/Variants for BAI2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for BAI2 (up to first 250kb)
|
Disorders & Mutations for BAI2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602683
|
Medical News for BAI2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for BAI2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for BAI2 gene (see all 14
):- Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PubMed id 9533023)1, 2, 3, 4 Shiratsuchi T.... Tokino T. (1997)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. (PubMed id 14697242)3 Nagaraja G.M. and Kandpal R.P. (2004)
- The human and mouse repertoire of the adhesion family of G-protein- coupled receptors. (PubMed id 15203201)3 Bjarnadottir T.K.... Schioeth H.B. (2004)
- Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. (PubMed id 12508107)3 Petersen H.H....Willnow T.E. (2003)
- Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. (PubMed id 12543931)3 Adkins J.N....Pounds J.G. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for BAI2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing BAI2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing BAI2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BAI2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for BAI2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for BAI2:

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Incremental update: 13 Oct 2009
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