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BAI1 Gene

protein-coding   GIFtS: 62

GC08P143542
brain-specific angiogenesis inhibitor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ41988 2
GDAIF 2
Descriptions
brain-specific angiogenesis inhibitor 1 2
External Ids
HGNC: 9431
Entrez Gene: 5752
UniProtKB: O145143
Ensembl: ENSG000001817907
Search outside databases for aliases for BAI1 gene

Previous GC identifers: GC08U990005 GC08P143719 GC08P143189 GC08P143444

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for BAI1:
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel
growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be
essential for growth and metastasis of solid tumors. In order to obtain blood supply for their
growth, tumor cells are potently angiogenic and attract new vessels as results of increased
secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at
least one 'functional' p53-binding site within an intron, and its expression has been
shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor
genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and
structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a
member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of
glioblastomas [provided by RefSeq]

UniProtKB/Swiss-Prot: BAI1_HUMAN, O14514
Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be
a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the
p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction
in the brain

Gene Wiki entry for BAI1 (Brain-specific_angiogenesis_inhibitor_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BAI1 gene  

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24

BAI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P143542:     (about GC identifiers)

Start:
143,542,379 bp from pter
End:
143,623,370 bp from pter
Size:
80,992 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000008.9  NT_008046.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BAI1_HUMAN, O14514 (See protein sequence)
Recommended Name: Brain-specific angiogenesis inhibitor 1 precursor  
Size: 1584 amino acids; 173533 Da
Subunit: Interacts with ELMO1 and DOCK1. When bound to ELMO1 and DOCK1, it may act as a module to
promote the engulfment (By similarity). Interacts with MAGI1, MAGI3, BAIAP2 and PHYHIP
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Likely to be concentrated at
cell-cell adhesion sites

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001693.2  

    ENSEMBL proteins: 
    ENSP00000313046 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (BAI1)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane TAS9647739 10343108
    GO:0005887 integral to plasma membrane TAS9647739
    GO:0005911 cell-cell junction TAS9647739
    About this table

    Antibodies for BAI1: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of BAI1
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (BAI1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (BAI1)
    Novus Biologicals Antibodies for BAI1

    Assays for BAI1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/8 InterPro domains/families (see all 8 ):
     IPR000884 Thrombospondin_1_rpt
     IPR008085 Thrombospondin_1_rpt_sub
     IPR008077 GPCR_2_brain-spec_angio_inhib
     IPR017983 GPCR_2_secretin-like_CS
     IPR001879 GPCR_2_extracellular


       GeneDecks  BAI1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O14514

    ProtoNet protein and cluster: O14514

    5 Blocks protein families:
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB000884 Thrombospondin
    IPB008077 Brain-specific angiogenesis inhibitor precursor signature
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: BAI1_HUMAN, O14514
    Domain: The TSP1 repeats inhibit in vivo angiogenesis in rat cornea induced by BFGF
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 1 GPS domain
    Similarity: Contains 5 TSP type-1 domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BAI1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BAI1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001702

                  Applied Biosystems Silencer® siRNAs for BAI1

                  Sigma-Aldrich siRNA and siRNA Panels for BAI1  
                         Sigma-Aldrich shRNA Panels and shRNA for BAI1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001702
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001702
                                     untagged cDNA clone in CMV expression vector: NM_001702 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001702

    UniProtKB/Swiss-Prot: BAI1_HUMAN, O14514
    Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be
    a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the
    p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction
    in the brain
    Induction: By p53

    Genatlas biochemistry entry for BAI1:
    brain specific angiogenesis inhibitor 1,induced by TP53,expressed in brain,suppressor of
    glioblastoma family

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI9647739 9790924 10343108 11245925
    GO:0016527 brain-specific angiogenesis inhibitor activity TAS14980512
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for BAI1
     Selected targets of p53

       GeneDecks  BAI1 for the pathways selected above  
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    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  BAI1  (Your Favorite Gene powered by Ingenuity) 
     p53 Signaling

       GeneDecks  BAI1 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for BAI1):
     hsa04115 p53 signaling pathway

       GeneDecks  BAI1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  BAI1 


    5/13 Interacting proteins for BAI1 (ENSP000003130463 O145141, 2) via UniProtKB, MINT, and/or STRING (see all 13 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAIAP3O948121STRING (score=.927) EBI-1995178, EBI-1995203
    BAIAP2ENSP000003163383STRING (score=.978)
    TP53ENSP000002693053STRING (score=.965)
    DOCK1ENSP000002803333STRING (score=.913)
    SRCENSP000003626593STRING (score=.909)
    About this table

    5 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155 cell adhesion TAS9647739
    GO:0007218 neuropeptide signaling pathway IEA--
    GO:0007409 axonogenesis TAS10343108
    GO:0007422 peripheral nervous system development TAS10343108
    GO:0008285 negative regulation of cell proliferation TAS7531056
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for BAI1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BAI1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BAI1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001702

                  Sigma-Aldrich siRNA and siRNA Panels for BAI1  
                         Sigma-Aldrich shRNA Panels and shRNA for BAI1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001702  

    REFSEQ mRNAs for BAI1 gene: 

    NM_001702.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001702  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001702
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001702
                                     untagged cDNA clone in CMV expression vector: NM_001702 

    Additional cDNA sequence: 

    AB005297.1 AK123982.1 

    3 DOTS entries:

    DT.208672  DT.101967103  DT.86840585 

    24/32 AceView cDNA sequences (see all 32 ):

    NM_001702 BG912470 AW117944 AB005297 BG911746 BF527323 AI366534 BG819644 
    AK123982 BG819770 BF515543 BG680852 AI151122 BU146414 D60158 AI608632 
    AW165986 BF514070 D61322 D61109 D80904 CD579693 D60514 BQ338401 

    highest scoring ESTs for BAI1:

    AB005297 AI151122 AI366534 AI608632 AW117944 AW165986 BF514070 BF515543 BF527323 BG680852 

    Unigene Cluster for BAI1:

    Brain-specific angiogenesis inhibitor 1
    Hs.194654  [show with all ESTs]
    Unigene Representative Sequence: NM_001702


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000323289  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    BAI1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for BAI1

    1 / 2 / 3

    3 probe-sets matching BAI1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35897_r_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB005297 1.00 1.00 1.00 1

    206083_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001702 0.60 1.00 0.82 1

    206083_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  BAI1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCCCCCAGGG

    SOURCE GeneReport for Unigene cluster: Hs.194654

    Expression variation in blood from EXPOLDB for BAI1

    UniProtKB/Swiss-Prot: BAI1_HUMAN, O14514
    Tissue specificity: Specifically expressed in brain. Reduced or no expression is observed in some
    glioblastoma cell lines and cancer tissues. No expression in astrocytes

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for BAI1 gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    cow
    (Bos taurus)
    BAI11   -- similar to brain-specific angiogenesis inhibitor 1 90.81(n)
    93.91(a)
    524070  XM_602388.3  XP_602388.3 
    rat
    (Rattus norvegicus)
    Bai11   -- brain-specific angiogenesis inhibitor 1 86.26(n)
    92.26(a)
    362931  XM_343260.3  XP_343261.3 
    mouse
    (Mus musculus)
    Bai11, 5 155
    brain-specific angiogenesis inhibitor 11, 5 88.33(n)1
    94.18(a)1
    1078311  NM_174991.31  NP_778156.21 
     AI8517245  AK0468315  (see all 18)
    zebrafish
    (Danio rerio)
    Dr.152372   -- Transcribed sequence with moderate similarity to protein more 77.5(n)  BM185566.1 
    About this table        Species with no ortholog for BAI1

    ENSEMBL Gene Tree for BAI1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for BAI1 gene
    BAI32  BAI22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/366 NCBI SNPs in BAI1 are shown (see all 366 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 78)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs132658261,2
    A143623617(+) TCAGGA/GAACCC 1 -- ng310--------
    --
    rs132653331,2
    A143623487(+) GGACTC/GTGGAG 1 -- ng310--------
    --
    rs96505811,2
    A143623035(+) GGGCCC/GAGGCC 1 -- ut31 ese30--------
    rs343649161,2
    F143620461(-) CCGTGC/AAGGTG 1 L/L syn11Minor allele frequency- A:0.14NA 42
    --
    rs74606001,2
    C143600420(+) ATGGCC/GGTGAC 1 A/A syn10--------
    rs74625181,2
    A,C,F,H143617395(+) ACACGC/TATGTA 1 -- int18Minor allele frequency- T:0.16EU EA WA 838
    rs40747581,2
    A,C,F,H143563731(-) GGGAAA/CGTTTG 1 -- int14Minor allele frequency- C:0.34EU EA WA 418
    rs40747591,2
    A,C,F,H143563506(-) CCAGGC/TCCCTC 1 -- int14Minor allele frequency- T:0.29EU EA WA 418
    rs49770331,2
    A,C,F,H143590947(+) GTCTGG/AAAACA 1 -- int13Minor allele frequency- A:0.49EA WA 296
    rs74600471,2
    A,C,F,H143617402(+) TGTACG/ATGTAC 1 -- int18Minor allele frequency- A:0.09EU EA WA 838
    About this table

    HapMap Linkage Disequilibrium images for BAI1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 602682

    6 Novoseek disease relationships for BAI1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 55.68 9 16244591 (4), 16796906 (2), 9533023 (1), 12507886 (1)
    gastric cancer 21.91 2 17374440 (1), 11172604 (1)
    tumors 14.46 3 16244591 (1), 11172604 (1)
    colorectal cancer 14.20 5 9772287 (4), 10568831 (1)
    metastasis 5.65 3 9772287 (2), 11172604 (1)
    cancer 0.00 1 10568831 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/27 PubMed articles for BAI1 gene (see all 27 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 575 HGNC: 943 AceView: BAI1 Ensembl:ENSG00000181790 euGenes: HUgn575
    ECgene: BAI1 H-InvDB: BAI1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for BAI1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for BAI1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Antibodies for BAI1

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