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Aliases & Descriptions for BAI1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| brain-specific angiogenesis inhibitor 1 2 |
|
| | Search outside databases for aliases for BAI1 genePrevious GC identifers: GC08U990005 GC08P143719 GC08P143189 GC08P143444 |
Summaries for BAI1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for BAI1: Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq] UniProtKB/Swiss-Prot: BAI1_HUMAN, O14514Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brainGene Wiki entry for BAI1 (Brain-specific_angiogenesis_inhibitor_1) |
Genomic Location for BAI1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the BAI1 gene 
Entrez Gene cytogenetic band: 8q24 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24BAI1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P143542:
(about GC identifiers)
Start:
|
143,542,379 bp from pter |
End:
|
143,623,370 bp from pter |
Size:
|
80,992 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000008.9 NT_008046.15
| Proteins for BAI1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: BAI1_HUMAN, O14514 (See
protein sequence)Recommended Name: Brain-specific angiogenesis inhibitor 1 precursor Size: 1584 amino acids; 173533 Da
Subunit: Interacts with ELMO1 and DOCK1. When bound to ELMO1 and DOCK1, it may act as a module to promote the engulfment (By similarity). Interacts with MAGI1, MAGI3, BAIAP2 and PHYHIP
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Likely to be concentrated at cell-cell adhesion sitesPost-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001693.2
ENSEMBL proteins: ENSP00000313046
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for BAI1: Assays for BAI1: | Protein
Domains/ Families for BAI1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O14514
ProtoNet protein and cluster: O14514 5 Blocks protein families: IPB000203 GPS domain IPB000832 G-protein coupled receptors family 2 (secretin-like) IPB000884 Thrombospondin IPB008077 Brain-specific angiogenesis inhibitor precursor signature IPB008085 Thrombospondin type 1 repeat signature
UniProtKB/Swiss-Prot: BAI1_HUMAN, O14514Domain: The TSP1 repeats inhibit in vivo angiogenesis in rat cornea induced by BFGFSimilarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamilySimilarity: Contains 1 GPS domainSimilarity: Contains 5 TSP type-1 domains | Gene Function for BAI1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001702
Applied Biosystems Silencer® siRNAs for BAI1
Sigma-Aldrich siRNA and siRNA Panels for BAI1  Sigma-Aldrich shRNA Panels and shRNA for BAI1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001702                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001702                                  untagged cDNA clone in CMV expression vector: NM_001702 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001702
UniProtKB/Swiss-Prot: BAI1_HUMAN, O14514Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brainInduction: By p53Genatlas biochemistry entry for BAI1:brain specific angiogenesis inhibitor 1,induced by TP53,expressed in brain,suppressor of glioblastoma family2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for BAI1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for BAI1 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for BAI1 
5/13 Interacting proteins for BAI1 (ENSP000003130463 O145141, 2) via UniProtKB, MINT, and/or STRING (see all 13
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for BAI1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for BAI1
|
Transcripts for BAI1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001702
Sigma-Aldrich siRNA and siRNA Panels for BAI1  Sigma-Aldrich shRNA Panels and shRNA for BAI1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001702 REFSEQ mRNAs for BAI1 gene: NM_001702.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001702               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001702                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001702                                  untagged cDNA clone in CMV expression vector: NM_001702  Additional cDNA sequence: AB005297.1 AK123982.1 3 DOTS entries: DT.208672 DT.101967103 DT.86840585 24/32 AceView cDNA sequences (see all 32
):NM_001702 BG912470 AW117944 AB005297 BG911746 BF527323 AI366534 BG819644 AK123982 BG819770 BF515543 BG680852 AI151122 BU146414 D60158 AI608632 AW165986 BF514070 D61322 D61109 D80904 CD579693 D60514 BQ338401
highest scoring ESTs for BAI1:AB005297 AI151122 AI366534 AI608632 AW117944 AW165986 BF514070 BF515543 BF527323 BG680852 Unigene Cluster for BAI1: Brain-specific angiogenesis inhibitor 1 Hs.194654 [show with all ESTs]Unigene Representative Sequence: NM_001702
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000323289
|
Expression for BAI1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| BAI1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for BAI1
1 / 2 / 3 3 probe-sets matching BAI1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCCCCCAGGG
SOURCE GeneReport for Unigene cluster: Hs.194654
Expression variation in blood from EXPOLDB for BAI1 UniProtKB/Swiss-Prot: BAI1_HUMAN, O14514Tissue specificity: Specifically expressed in brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues. No expression in astrocytes |
Orthologs for BAI1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BAI1 gene from 4 species
About this table Species with no ortholog for BAI1
ENSEMBL Gene Tree for BAI1 | Paralogs for BAI1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for BAI1 gene
- BAI32 BAI22
|
SNPs/Variants for BAI1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for BAI1 (up to first 250kb)
|
Disorders & Mutations for BAI1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602682
6 Novoseek disease relationships for BAI1 gene
About this table
|
Medical News for BAI1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for BAI1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/27 PubMed articles for BAI1 gene (see all 27
):- Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. (PubMed id 10343108)1, 3, 4 Oda K.... Tokino T. (1999)
- Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. (PubMed id 9647739)1, 3, 4 Shiratsuchi T....Tokino T. (1998)
- Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PubMed id 9533023)1, 2, 3 Shiratsuchi T.... Tokino T. (1997)
- Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. (PubMed id 12507886)1, 3, 4 Kaur B....Van Meir E.G. (2003)
- Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. (PubMed id 11875720)3, 4 Duda D.G....Matsuno S. (2002)
- Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells. (PubMed id 12074842)3, 4 Mori K....Arita N. (2002)
- Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. (PubMed id 10748157)3, 4 Wu Y....Lasky L.A. (2000)
- A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis. (PubMed id 9393972)3, 4 Nishimori H.... Tokino T. (1997)
- Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein. (PubMed id 11245925)1, 3 Koh J.T....Kim K.K. (2001)
- Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin. (PubMed id 14980512)1, 3 Koh J.T....Kim K.K. (2004)
|
Search for BAI1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing BAI1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing BAI1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BAI1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for BAI1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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