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Aliases for BAHD1 Gene

Aliases for BAHD1 Gene

  • Bromo Adjacent Homology Domain Containing 1 2 3
  • KIAA0945 4 6
  • BAH Domain-Containing Protein 1 4

External Ids for BAHD1 Gene

Previous GeneCards Identifiers for BAHD1 Gene

  • GC15P038447
  • GC15P038449
  • GC15P038520
  • GC15P040733
  • GC15P017594

Summaries for BAHD1 Gene

GeneCards Summary for BAHD1 Gene

BAHD1 (Bromo Adjacent Homology Domain Containing 1) is a Protein Coding gene. Diseases associated with BAHD1 include listeriosis. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for BAHD1 Gene

  • Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAHD1 Gene

Genomics for BAHD1 Gene

Regulatory Elements for BAHD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BAHD1 Gene

Start:
40,439,721 bp from pter
End:
40,468,242 bp from pter
Size:
28,522 bases
Orientation:
Plus strand

Genomic View for BAHD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAHD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAHD1 Gene

Proteins for BAHD1 Gene

  • Protein details for BAHD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBE0-BAHD1_HUMAN
    Recommended name:
    Bromo adjacent homology domain-containing 1 protein
    Protein Accession:
    Q8TBE0
    Secondary Accessions:
    • Q8NDF7
    • Q9Y2F4

    Protein attributes for BAHD1 Gene

    Size:
    780 amino acids
    Molecular mass:
    84652 Da
    Quaternary structure:
    • Interacts with CBX5 (HP1 alpha), HDAC5, MBD1 and SP1. Forms a transcription silencing complex with at least CBX3 (HP1 gamma), HDAC1, HDAC2 and TRIM28. Interacts with L.monocytogenes LntA; this interaction, occurring at a late Listeria infection stage, relieves transcription repression, mostly that of interferon-stimulated genes.
    SequenceCaution:
    • Sequence=BAA76789.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for BAHD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAHD1 Gene

Proteomics data for BAHD1 Gene at MOPED

Post-translational modifications for BAHD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BAHD1 Gene

No data available for DME Specific Peptides for BAHD1 Gene

Domains for BAHD1 Gene

Protein Domains for BAHD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BAHD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBE0

UniProtKB/Swiss-Prot:

BAHD1_HUMAN :
  • Q8TBE0
Domain:
  • The BAH domain is required for localization at H3K27me3.
  • Contains 1 BAH domain.
genes like me logo Genes that share domains with BAHD1: view

No data available for Gene Families for BAHD1 Gene

Function for BAHD1 Gene

Molecular function for BAHD1 Gene

UniProtKB/Swiss-Prot Function: Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3.

Gene Ontology (GO) - Molecular Function for BAHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA --
GO:0003682 chromatin binding IDA 19666599
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with BAHD1: view

Phenotypes for BAHD1 Gene

MGI mutant phenotypes for BAHD1:
inferred from 1 alleles
GenomeRNAi human phenotypes for BAHD1:
genes like me logo Genes that share phenotypes with BAHD1: view

Animal Models for BAHD1 Gene

MGI Knock Outs for BAHD1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BAHD1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BAHD1 Gene

Localization for BAHD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAHD1 Gene

Nucleus. Chromosome. Note=Localizes to heterochromatin and inactive X chromosome. Colocalizes with histone H3 trimethylated at Lys-27 (H3K27me3).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAHD1 Gene COMPARTMENTS Subcellular localization image for BAHD1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BAHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0005654 nucleoplasm IDA --
GO:0005677 chromatin silencing complex IDA 19666599
GO:0005694 chromosome --
genes like me logo Genes that share ontologies with BAHD1: view

Pathways for BAHD1 Gene

SuperPathways for BAHD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BAHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006342 chromatin silencing IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0031507 heterochromatin assembly IMP 19666599
GO:0045892 negative regulation of transcription, DNA-templated IMP 19666599
genes like me logo Genes that share ontologies with BAHD1: view

No data available for Pathways by source for BAHD1 Gene

Transcripts for BAHD1 Gene

Unigene Clusters for BAHD1 Gene

Bromo adjacent homology domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BAHD1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for BAHD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAHD1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for BAHD1 Gene

GeneLoc Exon Structure for
BAHD1
ECgene alternative splicing isoforms for
BAHD1

Expression for BAHD1 Gene

mRNA expression in normal human tissues for BAHD1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAHD1 Gene

SOURCE GeneReport for Unigene cluster for BAHD1 Gene Hs.22109

genes like me logo Genes that share expressions with BAHD1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BAHD1 Gene

Orthologs for BAHD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAHD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAHD1 35
  • 97.95 (n)
  • 96.15 (a)
BAHD1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAHD1 35
  • 88.65 (n)
  • 91.9 (a)
BAHD1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAHD1 35
  • 89.62 (n)
  • 93.15 (a)
BAHD1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bahd1 35
  • 86.92 (n)
  • 91.71 (a)
Bahd1 16
Bahd1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BAHD1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAHD1 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bahd1 35
  • 87 (n)
  • 91.68 (a)
chicken
(Gallus gallus)
Aves BAHD1 35
  • 61.19 (n)
  • 59.07 (a)
BAHD1 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BAHD1 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bahd1 35
  • 58.58 (n)
  • 55.57 (a)
zebrafish
(Danio rerio)
Actinopterygii bahd1 36
  • 34 (a)
OneToMany
BAHD1 (2 of 2) 36
  • 30 (a)
OneToMany
LOC100331694 35
  • 61.04 (n)
  • 58.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hers 36
  • 8 (a)
OneToOne
Species with no ortholog for BAHD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAHD1 Gene

ENSEMBL:
Gene Tree for BAHD1 (if available)
TreeFam:
Gene Tree for BAHD1 (if available)

Paralogs for BAHD1 Gene

No data available for Paralogs for BAHD1 Gene

Variants for BAHD1 Gene

Sequence variations from dbSNP and Humsavar for BAHD1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs8826 -- 40,467,917(+) GAGAT(C/G)AAGGC utr-variant-3-prime, nc-transcript-variant
rs14363 -- 40,467,956(-) AAGTT(C/T)GGGGC utr-variant-3-prime, nc-transcript-variant
rs73309 -- 40,452,865(-) TGGGG(A/G)GTTCA intron-variant
rs586558 -- 40,438,608(-) CCAAC(C/T)GGAGA upstream-variant-2KB
rs592976 -- 40,445,277(-) GGGTT(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAHD1 Gene

Variant ID Type Subtype PubMed ID
esv34145 CNV Loss 18971310
esv2666703 CNV Deletion 23128226

Relevant External Links for BAHD1 Gene

HapMap Linkage Disequilibrium report
BAHD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAHD1 Gene

Disorders for BAHD1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BAHD1 Gene including...

Search for BAHD1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for BAHD1 Gene

Relevant External Links for BAHD1

Genetic Association Database (GAD)
BAHD1
Human Genome Epidemiology (HuGE) Navigator
BAHD1
genes like me logo Genes that share disorders with BAHD1: view

No data available for UniProtKB/Swiss-Prot for BAHD1 Gene

Publications for BAHD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Human BAHD1 promotes heterochromatic gene silencing. (PMID: 19666599) Bierne H. … Cossart P. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. (PMID: 21252314) Lebreton A. … Bierne H. (Science 2011) 3 4
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for BAHD1 Gene

Sources for BAHD1 Gene

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