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BAHD1 Gene

protein-coding GIFtS: 51

GC15P038520

bromo adjacent homology domain containing 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KIAA0945 ^¹, ², ³

Descriptions
BAH domain-containing protein 1 ^³
bromo adjacent homology domain containing 1 ^²

External Ids
HGNC: 29153¹
Entrez Gene: 22893²
UniProtKB: Q8TBE0³
Ensembl: ENSG00000140320⁷

Search outside databases for aliases for BAHD1 gene

Previous GC identifers: GC15P038447 GC15P038449

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BAHD1 gene

Entrez Gene cytogenetic band: 15q15.1 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q14

BAHD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P038520: (about GC identifiers)

Start:	38,520,703 bp from pter
End:	38,547,733 bp from pter
Size:	27,031 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BAHD1_HUMAN, Q8TBE0 (See protein sequence)

Recommended Name: Bromo adjacent homology domain-containing 1 protein

Size: 780 amino acids; 84652 Da

Secondary accessions: Q8NDF7 Q9Y2F4

Alternative splicing: 3 isoforms: Q8TBE0-1 Q8TBE0-2 Q8TBE0-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055767.3

ENSEMBL proteins:

ENSP00000342391

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BAHD1)
	Human Recombinant Proteins from Abnova (BAHD1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for BAHD1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (BAHD1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BAHD1)
	Novus Biologicals Antibody for BAHD1

Assays for BAHD1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q8TBE0

ProtoNet protein and cluster: Q8TBE0

UniProtKB/Swiss-Prot: BAHD1_HUMAN, Q8TBE0

Similarity: Contains 1 BAH domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BAHD1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BAHD1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014952

Applied Biosystems Silencer® siRNAs for BAHD1

Sigma-Aldrich siRNA for BAHD1

Sigma-Aldrich shRNA for BAHD1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BAHD1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014952
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014952
untagged cDNA clone in CMV expression vector: NM_014952

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014952

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/8 Interacting proteins for BAHD1 (Q8TBE0²) via UniProtKB, MINT, and/or STRING (see all 8 )
Interactant Interaction Details
GeneCard External ID(s)
BEGAIN Q9BUH8² MINT-66517
DVL2 O14641² MINT-67574
KHDRBS3 O75525² MINT-66350
KRTAP4-12 Q9BQ66² MINT-66603
LOC100132876 Q9BQ66² MINT-66603
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BAHD1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BAHD1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BAHD1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014952

Sigma-Aldrich siRNA for BAHD1

Sigma-Aldrich shRNA for BAHD1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014952

REFSEQ mRNAs for BAHD1 gene:

NM_014952.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014952

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014952
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014952
                                 untagged cDNA clone in CMV expression vector: NM_014952

Additional cDNA sequence:

AB023162.1 AL833923.1 BC022782.2 BC109237.1

5 DOTS entries:

DT.416393 DT.100746635 DT.416394 DT.95360180 DT.121636752

24/200 AceView cDNA sequences (see all 200 ):

BM679752 AI979002 N73215 AI363395 BU733593 BM560919 AI694112 AI870753

BM709581 AI198372 BM981326 BE504915 BM713960 AI139638 BF939245 Z41341

AW299339 NM_014952 AI559541 AI992094 N54062 BM913398 AI580800 BE218502

highest scoring ESTs for BAHD1:

AB023162 AA133483 AA133484 AA393131 AA398538 AA412187 AA416954 AA515217 AA515624 AA524007

Unigene Cluster for BAHD1:

Bromo adjacent homology domain containing 1

Hs.22109 [show with all ESTs]

Unigene Representative Sequence: AB023162

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for BAHD1

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c
SP1:											-
SP2:											-
SP3:											-		-
SP4:

About this scheme

ECgene alternative splicing isoforms for BAHD1

1 Ensembl transcript including schematic representation:

ENST00000339351

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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BAHD1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BAHD1

¹ / ² / ³

3 probe-sets matching BAHD1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33365_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AB023162	1.00	1.00	1.00	1
203051_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014952	0.60	1.00	0.82	1
203051_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks BAHD1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAAATATAT

SOURCE GeneReport for Unigene cluster: Hs.22109
Expression variation in blood from EXPOLDB for BAHD1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BAHD1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BAHD1¹	--	bromo adjacent homology domain containing 1	89.62(n) 93.18(a)	487495 XM_544619.2 XP_544619.2
cow (Bos taurus)	BAHD1¹	--	bromo adjacent homology domain containing 1	88.65(n) 91.9(a)	617684 XM_869991.2 XP_875084.2
rat (Rattus norvegicus)	Bahd1¹	--	bromo adjacent homology domain containing 1	87(n) 91.71(a)	362194 XM_347035.3 XP_347036.3
mouse (Mus musculus)	Bahd1^{1, 5}	2⁵	bromo adjacent homology domain containing 1^{1, 5}	86.96(n)¹ 91.71(a)¹	228536¹ NM_001045523.1¹ NP_001038988.1¹ AI851057⁵ AK129243⁵ (see all 19)
chicken (Gallus gallus)	BAHD1¹	--	bromo adjacent homology domain containing 1	61.85(n) 59.87(a)	423010 XM_420941.2 XP_420941.2

About this table Species with no ortholog for BAHD1

ENSEMBL Gene Tree for BAHD1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/114 NCBI SNPs in BAHD1 are shown (see all 114 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3803357^1,2	A,C,F,H	38538847(-)	`GGGCTT/GATGAG`	1	K/Q	mis¹		14		EA EU WA NA	2756
	rs679882^1,2	A,C,F,H	38546639(-)	`AGGTCC/TGTGGA`	1	--	ut3¹ ese³		6		NA EU EA WA	442
	rs6492946^1,2	A,C,F,H	38519403(+)	`GGCACG/ATCTGT`	1	--	ng5¹		4		EU EA WA	416
	rs3743143^1,2	C,F,H	38538032(+)	`GATGGA/GAGACA`	1	E/G	mis¹		10		EA EU WA NA	2406
	rs3743145^1,2	A,C,H	38545629(+)	`TCCTCC/ATGCCC`	1	--	ut3¹ ese³		4		EU EA WA	414
	rs8826^1,2	A,C	38547408(+)	`GAGATG/CAAGGC`	1	--	ut3¹ ese³		1		MN	184
--	rs17856679^1,2	H	38538499(+)	`GTCGGG/CACCTG`	1	H/D	mis¹		4		EU EA WA	352
	rs12440175^1,2	C	38518986(+)	`AGCCCA/CTGGGC`	1	--	ng5¹		0	--	--	--	--
--	rs17339596^1,2	F	38538834(+)	`TCCGTC/TCAGCC`	1	V/V	syn¹ ese³		1		MN	184
	rs603104^1,2	A,C,F,H,O	38544327(-)	`CTGTTG/TCCAGG`	1	--	int¹		15		EA NA EU WA	1108

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HapMap Linkage Disequilibrium images for BAHD1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

9 PubMed articles for BAHD1 gene:

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{2, 3, 4} Nagase T....Ohara O. (1999)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)⁴ Zody M.C....Nusbaum C. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. (PubMed id 12421765)³ Nakayama M....Ohara O. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)³ Bonaldo M.F....Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 22893	HGNC: 29153	AceView: BAHD1	Ensembl:ENSG00000140320	euGenes: HUgn22893
ECgene: BAHD1	H-InvDB: BAHD1

(According to HUGE)
About This Section

HUGE: KIAA0945

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for BAHD1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BAHD1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BAHD1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BAHD1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BAHD1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BAHD1)
	Antibodies (BAHD1)
	Chimera RNAi (BAHD1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (BAHD1)

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Search Tocris compounds for BAHD1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BAHD1

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BAHD1 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for BAHD1

Summaries
for BAHD1

Genomic Location
for BAHD1

Proteins
for BAHD1

Protein Domains/
Families
for BAHD1

Gene Function
for BAHD1

Pathways & Interactions
for BAHD1

Drugs & Compounds
for BAHD1

Transcripts
for BAHD1

Expression
for BAHD1

Orthologs
for BAHD1

Paralogs
for BAHD1

SNPs/Variants
for BAHD1

Disorders & Mutations
for BAHD1

Medical News
for BAHD1

Publications
for BAHD1

Search for BAHD1

Genome Databases showing BAHD1

Other Databases showing BAHD1

Specialized Databases showing BAHD1

Licensable Technologies
for BAHD1

Services
for BAHD1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BAHD1 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor BAHD1

Summariesfor BAHD1

Genomic Locationfor BAHD1

Proteinsfor BAHD1

Protein Domains/Familiesfor BAHD1

Gene Functionfor BAHD1

Pathways & Interactionsfor BAHD1

Drugs & Compoundsfor BAHD1

Transcriptsfor BAHD1

Expression for BAHD1

Orthologsfor BAHD1

Paralogsfor BAHD1

SNPs/Variantsfor BAHD1

Disorders & Mutationsfor BAHD1

Medical Newsfor BAHD1

Publicationsfor BAHD1

Search for BAHD1

Genome Databases showing BAHD1

Other Databases showing BAHD1

Specialized Databases showing BAHD1

Licensable Technologiesfor BAHD1

Servicesfor BAHD1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BAHD1

Summaries
for BAHD1

Genomic Location
for BAHD1

Proteins
for BAHD1

Protein Domains/
Families
for BAHD1

Gene Function
for BAHD1

Pathways & Interactions
for BAHD1

Drugs & Compounds
for BAHD1

Transcripts
for BAHD1

Expression
for BAHD1

Orthologs
for BAHD1

Paralogs
for BAHD1

SNPs/Variants
for BAHD1

Disorders & Mutations
for BAHD1

Medical News
for BAHD1

Publications
for BAHD1

Licensable Technologies
for BAHD1

Services
for BAHD1