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BAGE5 Gene

protein-coding   GIFtS: 26
GCID: GC00M8E0002

B Melanoma Antigen Family, Member 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
B Melanoma Antigen Family, Member 51 2     Member 51
Cancer/Testis Antigen 2.52 3     B Melanoma Antigen 52
CT2.52 3     Cancer/Testis Antigen Family 2, Member 52
Cancer/Testis Antigen Family 21     

External Ids:    HGNC: 157321   Entrez Gene: 853162   Ensembl: ENSG000002685907   UniProtKB: Q86Y273   

Export aliases for BAGE5 gene to outside databases

Previous GC identifers: GC13U990073 GC21M010120 GC21M010046 GC21M010073 GC21M010074 GC21M010998 GC07M151833


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BAGE5 Gene:
BAGE5 (B melanoma antigen family, member 5) is a protein-coding gene. An important paralog of this gene is ENSG00000256715.

UniProtKB/Swiss-Prot: BAGE5_HUMAN, Q86Y27
Function: Unknown. Candidate gene encoding tumor antigens




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for BAGE5
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BAGE5


Genomic Location:
Chromosome:--   

Entrez Gene cytogenetic band: 13cen   Ensembl cytogenetic band:  Un_GL000237.1   HGNC chromosome: 13cen

        GeneLoc Exon Structure

GeneLoc location for GC00M8E0002:       (about GC identifiers)

Start:
899 bp from pter      End:
2,487 bp from pter
Size:
1,589 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: BAGE5_HUMAN, Q86Y27 (See protein sequence)
Recommended Name: B melanoma antigen 5 precursor  
Size: 43 amino acids; 4711 Da
Miscellaneous: The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The
BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of
expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene
fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18
and 21

Explore the universe of human proteins at neXtProt for BAGE5: NX_Q86Y27

REFSEQ proteins: NP_872290.1  
ENSEMBL proteins: 
 ENSP00000472450  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR012530 BAGE

Graphical View of Domain Structure for InterPro Entry Q86Y27

ProtoNet protein and cluster: Q86Y27

1 Blocks protein domain: IPB012530 B melanoma antigen

UniProtKB/Swiss-Prot: BAGE5_HUMAN, Q86Y27
Similarity: Belongs to the BAGE family


Find genes that share domains with BAGE5           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: BAGE5_HUMAN, Q86Y27
Function: Unknown. Candidate gene encoding tumor antigens

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
BAGE5_HUMAN, Q86Y27: Secreted (Potential)

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with BAGE5           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for BAGE5 gene: 
NM_182484.1  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000602027
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

BAGE5 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

UniProtKB/Swiss-Prot: BAGE5_HUMAN, Q86Y27
Tissue specificity: Not expressed in normal tissues except in testis. Expressed in melanoma, bladder and lung
carcinomas

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for BAGE5 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia --
Uncharacterized protein
77(a)
1 → many
18(1618804-1622265)


ENSEMBL Gene Tree for BAGE5 (if available)
TreeFam Gene Tree for BAGE5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for BAGE5 gene
ENSG000002567152  
4 SIMAP similar genes for BAGE5 using alignment to 1 protein entry:     BAGE5_HUMAN:
BAGE2    BAGE3    BAGE    BAGE4

Find genes that share paralogs with BAGE5           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) Selected variations for BAGE5 (see all 41):    About this table    
Variant IDTypeSubtypePubMed ID
esv2563009CNV Deletion19546169
dgv73n16CNV Deletion17901297
esv2661615CNV Deletion23128226
nsv436329CNV Deletion17901297
esv2474693CNV Deletion19546169
esv999403CNV Deletion20482838
esv2675165CNV Deletion23128226
nsv435743CNV Deletion17901297
esv1002199CNV Deletion20482838
esv987944CNV Deletion20482838

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for BAGE5 gene integrated from 10 sources:
(articles sorted by number of sources associating them with BAGE5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. BAGE genes generated by juxtacentromeric reshuffling in the hominidae lineage are under selective pressure. (PubMed id 12676563)1, 2, 3 Ruault M.... De Sario A. (Genomics 2003)
  2. New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. (PubMed id 12461691)1, 2, 3 Ruault M....De Sario A. (Eur. J. Hum. Genet. 2002)
  3. BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. (PubMed id 7895173)1 Boel P.... van der Bruggen P. (Immunity 1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 85316 HGNC: 15732 Ensembl:ENSG00000268590 euGenes: HUgn85316 ECgene: BAGE5
H-InvDB: BAGE5

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for BAGE5 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BAGE5 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for BAGE5 gene:
Search GeneIP for patents involving BAGE5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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