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BAGE3 Gene

protein-coding   GIFtS: 29

GC21M010042
B melanoma antigen family, member 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CT2.3 1, 2, 3
Descriptions
B melanoma antigen family, member 3 2
Cancer/testis antigen 2.3 3
cancer/testis antigen family 2, member 3 2
External Ids
HGNC: 157281
Entrez Gene: 853182
UniProtKB: Q86Y293
Ensembl: ENSG000001871727
Search outside databases for aliases for BAGE3 gene

Previous GC identifers: GC00U991012 GC21M010071 GC21M010044

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: BAGE3_HUMAN, Q86Y29
Function: Unknown. Candidate gene encoding tumor antigens

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21p11.2   Ensembl cytogenetic band:  21p11.1   HGNC cytogenetic band: 21p11.2

BAGE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M010042:     (about GC identifiers)

Start:
10,042,713 bp from pter
End:
10,120,608 bp from pter
Size:
77,896 bases
Orientation:
minus strand
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BAGE3_HUMAN, Q86Y29 (See protein sequence)
Recommended Name: B melanoma antigen 3 precursor  
Size: 109 amino acids; 12112 Da
Subcellular location: Secreted (Potential)
Miscellaneous: The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3
gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE
family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13
and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several
chromosomes, including chromosomes 9, 13, 18 and 21

REFSEQ proteins: NP_872287.1  

ENSEMBL proteins: 
ENSP00000349289 ENSP00000335528 


Human Recombinant Proteins 
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Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
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Antibodies for BAGE3: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for BAGE3
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for BAGE3

Assays for BAGE3: 
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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR012530 BAGE


   GeneDecks  BAGE3 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q86Y29

ProtoNet protein and cluster: Q86Y29

1 Blocks protein family: IPB012530 B melanoma antigen

UniProtKB/Swiss-Prot: BAGE3_HUMAN, Q86Y29
Similarity: Belongs to the BAGE family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_182481

              Applied Biosystems Silencer® siRNAs for BAGE3

              Sigma-Aldrich siRNA for BAGE3  
                     Sigma-Aldrich shRNA for BAGE3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_182481
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_182481
                                 untagged cDNA clone in CMV expression vector: NM_182481 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_182481

UniProtKB/Swiss-Prot: BAGE3_HUMAN, Q86Y29
Function: Unknown. Candidate gene encoding tumor antigens

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/21 Interacting proteins for BAGE3 (ENSP000003355283) via UniProtKB, MINT, and/or STRING (see all 21 )
InteractantInteraction Details
GeneCardExternal ID(s)
MAGEA3ENSP000003593013STRING (score=.966)
ZNF594ENSP000003711713STRING (score=.96)
MAGEA1ENSP000003490853STRING (score=.956)
CARSENSP000003698973STRING (score=.899)
CD28ENSP000003248903STRING (score=.899)
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BAGE3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_182481

              Sigma-Aldrich siRNA for BAGE3  
                     Sigma-Aldrich shRNA for BAGE3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_182481  

REFSEQ mRNAs for BAGE3 gene: 

NM_182481.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_182481  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_182481
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_182481
                                 untagged cDNA clone in CMV expression vector: NM_182481 

20 AceView cDNA sequences:

NM_182482 AF218570 BG501498 CD359687 BC064647 NM_182481 AF339514 H55516 
NM_181704 NM_182484 AF339515 AF339516 BG723950 NM_001187 U19180 BE084888 
AV750850 AI138404 BC037276 AU099705 

highest scoring ESTs for BAGE3:

AU099705 BC037276 BG723950 AV750850 BC101134 BE084888 CD359687 NM_181704 NM_182481 NM_182482 


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000356832  ENST00000335369  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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BAGE3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for BAGE3

 / 2 / 3

2 probe-sets matching BAGE3 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

1555408_at2 U133Plus2 5 1.00 0.20 -- -- -- -- -- -- --

1555409_a_at2 U133Plus2 5 0.82 0.16 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

UniProtKB/Swiss-Prot: BAGE3_HUMAN, Q86Y29
Tissue specificity: Not expressed in normal tissues except in testis. Expressed in melanoma,
bladder and lung carcinomas

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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ENSEMBL Gene Tree for BAGE3
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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  --
(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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6 PubMed articles for BAGE3 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 85318 HGNC: 15728 AceView: BAGE3 Ensembl:ENSG00000187172 euGenes: HUgn85318
ECgene: BAGE3 H-InvDB: BAGE3
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
ATLAS Chromosomes in Cancer entry for BAGE3 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for BAGE3:
 TaqMan ® Gene Expression Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for BAGE3-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for BAGE3 Antibodies for BAGE3
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for BAGE3 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for BAGE3

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