BAGE3 Gene
protein-coding GIFtS: 29
GCID: GC21M010997
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B melanoma antigen family, member 3
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Aliases
for BAGE3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| B Melanoma Antigen Family, Member 31 2 | | CT2.31 2 3 | | Cancer/Testis Antigen 2.32 3 | | B Melanoma Antigen 32 | | Cancer/Testis Antigen Family 2, Member 32 |
Export aliases for BAGE3 gene to outside databasesPrevious GC identifers: GC00U991012 GC21M010071 GC21M010044 GC21M010042 |
Summaries
for BAGE3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: BAGE3_HUMAN, Q86Y29Function: Unknown. Candidate gene encoding tumor antigens
|
Genomic Views
for BAGE3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BAGE3 gene promoter:
GR RP58 Pax-5 AML1a GR-beta FOXO3 FOXO3b Nkx6-1 FOXO3a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for BAGE3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAGE3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21p11.2 HGNC cytogenetic band: 21p11.2BAGE3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21M010997: view genomic region
(about GC identifiers)
Start:
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11,020,842 bp from pter |
End:
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11,058,323 bp from pter |
Size:
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37,482 bases |
Orientation:
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minus strand |
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Proteins
for BAGE3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BAGE3_HUMAN, Q86Y29 (See
protein sequence)Recommended Name: B melanoma antigen 3 precursor Size: 109 amino acids; 12112 Da
Subcellular location: Secreted (Potential)
Miscellaneous: The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3 gene. The BAGE familywas expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genesthat map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered inthe juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21Explore the universe of human proteins at neXtProt for BAGE3: NX_Q86Y29
BAGE3 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_872287.1
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
BAGE3 for ontologies About GeneDecksing
BAGE3 Antibody Products:
Assay Products for BAGE3: |
Protein
Domains /
Families
for BAGE3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BAGE3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86Y29ProtoNet protein and cluster: Q86Y29 1 Blocks protein family: IPB012530 B melanoma antigen
UniProtKB/Swiss-Prot: BAGE3_HUMAN, Q86Y29Similarity: Belongs to the BAGE family |
Function
for BAGE3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BAGE3_HUMAN, Q86Y29Function: Unknown. Candidate gene encoding tumor antigens
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BAGE3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BAGE3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BAGE3 (NM_182481) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BAGE3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAGE3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAGE3 |
|
Pathways & Interactions
for BAGE3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BAGE3
|
Drugs & Compounds
for BAGE3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BAGE3
Search CenterWatch for drugs/clinical trials and news about BAGE3
|
Transcripts
for BAGE3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BAGE3 gene: NM_182481.1
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BAGE3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BAGE3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BAGE3 (NM_182481) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BAGE3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAGE3 |
20 AceView cDNA sequences: CD359687 BG501498 AF218570 NM_182482 BC064647 AF339514 H55516 NM_182481 NM_181704 BG723950 NM_182484 AF339515 AF339516 NM_001187 U19180 BE084888 AV750850 AI138404 BC037276 AU099705
GeneLoc Exon Structure
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Expression
for BAGE3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
Genevestigator expression for BAGE3
UniProtKB/Swiss-Prot: BAGE3_HUMAN, Q86Y29Tissue specificity: Not expressed in normal tissues except in testis. Expressed in melanoma, bladder and lungcarcinomas
SABiosciences Custom PCR Arrays for BAGE3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BAGE3
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat BAGE3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BAGE3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BAGE3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAGE3 |
Orthologs
for BAGE3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
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Paralogs
for BAGE3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for BAGE3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 27 variations for BAGE3
15/26 CNVs (see all 26): 23086 79305 61955 59034 23321 35942 73597 3224 22515 32434 7328 22855 90682 73600 5156
1 Indel: 40470 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for BAGE3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BAGE3 for disorders About GeneDecksing
4  diseases for BAGE3: About MalaCardsmelanoma holoprosencephaly lung carcinoma carcinoma
Export disorders for BAGE3 gene to outside databases
|
Publications
for BAGE3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BAGE3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with BAGE3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. (PubMed id 12461691)1, 2, 3 Ruault M....De Sario A. (2002)
- BAGE genes generated by juxtacentromeric reshuffling in the Hominidae lineage are under selective pressure. (PubMed id 12676563)1, 2 Ruault M....De Sario A. (2003)
- The diploid genome sequence of an individual human. (PubMed id 17803354)1 Levy S....Venter J.C. (2007)
- Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. (PubMed id 16009131)1 Carroll J.S....Brown M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. (PubMed id 7895173)1 Boel P.... van der Bruggen P. (1995)
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External Searches for BAGE3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing BAGE3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BAGE3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BAGE3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for BAGE3 gene:
Search GeneIP for patents involving BAGE3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BAGE3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BAGE3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BAGE3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BAGE3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BAGE3 | | OriGene 3'-UTR Clone for BAGE3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BAGE3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BAGE3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BAGE3 | | OriGene Custom Protein Services for BAGE3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BAGE3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BAGE3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAGE3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BAGE3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BAGE3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BAGE3 |
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| | | | Search Tocris compounds for BAGE3 |
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 | | | BAGE3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAGE3 |
|  |  |  | | | | Search ThermoFisher Antibodies for BAGE3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAGE3 |
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