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BAGE2 Gene(Protein Coding)

BAGE Family Member 2

GCID:
GC21P010413
GIFtS:
29
Genes Participants
UDN Logo

Aliases for BAGE2 Gene

Aliases for BAGE2 Gene

  • BAGE Family Member 2 2 3
  • Cancer/Testis Antigen Family 2, Member 2 2 3
  • B Melanoma Antigen Family Member 2 3 5
  • Cancer/Testis Antigen 2.2 3 4
  • CT2.2 3 4
  • B Melanoma Antigen Family, Member 2 2
  • B Melanoma Antigen 2 3

External Ids for BAGE2 Gene

Previous GeneCards Identifiers for BAGE2 Gene

  • GC21U990099
  • GC21M010043
  • GC21M010072
  • GC21M010996

Summaries for BAGE2 Gene

GeneCards Summary for BAGE2 Gene

BAGE2 (BAGE Family Member 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BAGE2 Gene

  • Unknown. Candidate gene encoding tumor antigens.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAGE2 Gene

Genomics for BAGE2 Gene

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  1. Regulatory Element

Regulatory Elements for BAGE2 Gene

Enhancers for BAGE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G010416 0.6 FANTOM5 1.9 +3.0 3039 0.4 SREBF1 ESRRA NFRKB IKZF1 CEBPG ZBTB33 HDAC8 ZNF507 BAGE2 LOC105378260
GH21G010327 0.5 FANTOM5 1.4 -86.0 -85967 0.4 ZNF507 BAGE2 EIF3FP1 LOC100420925
GH21G010429 0.5 FANTOM5 0.4 +16.5 16521 0.3 MYC ZNF354B BAGE2 LOC105378260
GH21G010422 0.3 FANTOM5 0.4 +8.7 8660 0.0 BAGE2 LOC105378260
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BAGE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BAGE2 Gene

Chromosome:
21
Start:
10,413,477 bp from pter
End:
10,516,431 bp from pter
Size:
102,955 bases
Orientation:
Plus strand

Genomic View for BAGE2 Gene

Genes around BAGE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAGE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAGE2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for BAGE2 Gene

Proteins for BAGE2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for BAGE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y30-BAGE2_HUMAN
    Recommended name:
    B melanoma antigen 2
    Protein Accession:
    Q86Y30
    Secondary Accessions:
    • A8K925
    • Q08ER0

    Protein attributes for BAGE2 Gene

    Size:
    109 amino acids
    Molecular mass:
    12114 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.

neXtProt entry for BAGE2 Gene

Post-translational modifications for BAGE2 Gene

No Post-translational modifications

Other Protein References for BAGE2 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for BAGE2 Gene

Domains & Families for BAGE2 Gene

Protein Domains for BAGE2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BAGE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y30

UniProtKB/Swiss-Prot:

BAGE2_HUMAN :
  • Belongs to the BAGE family.
Family:
  • Belongs to the BAGE family.
genes like me logo Genes that share domains with BAGE2: view

No data available for Gene Families for BAGE2 Gene

Function for BAGE2 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for BAGE2 Gene

UniProtKB/Swiss-Prot Function:
Unknown. Candidate gene encoding tumor antigens.
genes like me logo Genes that share phenotypes with BAGE2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BAGE2 Gene

Localization for BAGE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAGE2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for BAGE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with BAGE2: view

No data available for Subcellular locations from COMPARTMENTS for BAGE2 Gene

Pathways & Interactions for BAGE2 Gene

SuperPathways for BAGE2 Gene

PathCards logo More details on SuperPathways for BAGE2
No Data Available

Interacting Proteins for BAGE2 Gene

Gene Ontology (GO) - Biological Process for BAGE2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BAGE2 Gene

Drugs & Compounds for BAGE2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for BAGE2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for BAGE2 Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAGE2 Gene

No ASD Table

Relevant External Links for BAGE2 Gene

GeneLoc Exon Structure for
BAGE2
ECgene alternative splicing isoforms for
BAGE2

Expression for BAGE2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BAGE2 Gene

mRNA expression in normal human tissues for BAGE2 Gene
mRNA expression by GTEx for BAGE2 Gene

mRNA differential expression in normal tissues according to GTEx for BAGE2 Gene

This gene is overexpressed in Testis (x32.5) and Stomach (x6.7).

NURSA nuclear receptor signaling pathways regulating expression of BAGE2 Gene:

BAGE2

mRNA Expression by UniProt/SwissProt for BAGE2 Gene:

Q86Y30-BAGE2_HUMAN
Tissue specificity: Not expressed in normal tissues except in testis. Expressed in 22% of melanomas, in bladder and lung carcinomas.
genes like me logo Genes that share expression patterns with BAGE2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAGE2 Gene

Orthologs for BAGE2 Gene

Evolution for BAGE2 Gene

ENSEMBL:
Gene Tree for BAGE2 (if available)
TreeFam:
Gene Tree for BAGE2 (if available)

No data available for Orthologs for BAGE2 Gene

Paralogs for BAGE2 Gene

(4) SIMAP similar genes for BAGE2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BAGE2: view

No data available for Paralogs for BAGE2 Gene

Variants for BAGE2 Gene

Sequence variations from dbSNP and Humsavar for BAGE2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000233538 -- 10,413,499(-) ATGCA(C/T)ATGGG upstream-variant-2KB
rs1000978232 -- 10,445,295(-) TAGTA(A/G)CCAAC intron-variant
rs1001164393 -- 10,462,558(-) TATTC(C/T)TAATG intron-variant, upstream-variant-2KB
rs1001965476 -- 10,422,510(-) CCTCA(A/G)GTTAT intron-variant
rs1003344228 -- 10,440,748(-) CAGAG(A/G)CCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAGE2 Gene

Variant ID Type Subtype PubMed ID
dgv2349n106 CNV duplication 24896259
dgv2350n106 CNV deletion 24896259
dgv2351n106 CNV deletion 24896259
dgv2352n106 CNV deletion 24896259
dgv2353n106 CNV deletion 24896259
dgv2354n106 CNV deletion 24896259
dgv2468e59 CNV duplication 20981092
dgv4353n100 CNV loss 25217958
dgv4354n100 CNV gain+loss 25217958
dgv4355n100 CNV gain 25217958
dgv4356n100 CNV loss 25217958
dgv4358n100 CNV gain 25217958
dgv4363n100 CNV loss 25217958
dgv4367n100 CNV gain 25217958
dgv4368n100 CNV gain+loss 25217958
dgv4369n100 CNV gain 25217958
dgv4370n100 CNV loss 25217958
dgv4371n100 CNV gain 25217958
dgv4372n100 CNV loss 25217958
dgv4373n100 CNV gain+loss 25217958
dgv712n67 CNV gain 20364138
dgv73n16 CNV deletion 17901297
dgv7728n54 CNV gain 21841781
dgv7729n54 CNV gain 21841781
dgv7743n54 CNV gain 21841781
esv1000174 CNV deletion 20482838
esv1001067 CNV insertion 20482838
esv1002199 CNV deletion 20482838
esv1008267 CNV deletion 20482838
esv1008615 CNV deletion 20482838
esv2474693 CNV deletion 19546169
esv2563009 CNV deletion 19546169
esv2661615 CNV deletion 23128226
esv2675165 CNV deletion 23128226
esv2758808 CNV gain+loss 17122850
esv2760704 CNV gain 21179565
esv2763681 CNV gain+loss 21179565
esv28756 CNV gain+loss 19812545
esv29976 CNV gain 17803354
esv3057124 CNV deletion 24192839
esv32564 CNV gain+loss 17666407
esv3412511 CNV insertion 20981092
esv3557431 CNV deletion 23714750
esv3557434 CNV deletion 23714750
esv3646371 CNV loss 21293372
esv7291 CNV loss 19470904
esv9537 CNV loss 19470904
esv987944 CNV deletion 20482838
esv991443 OTHER inversion 20482838
esv999403 CNV deletion 20482838
esv999554 CNV insertion 20482838
nsv1057510 CNV loss 25217958
nsv1059291 CNV loss 25217958
nsv1059477 CNV gain 25217958
nsv1060052 CNV loss 25217958
nsv1064391 CNV loss 25217958
nsv1064913 CNV gain 25217958
nsv1071405 CNV deletion 25765185
nsv1071408 CNV deletion 25765185
nsv1071737 CNV deletion 25765185
nsv1071738 CNV deletion 25765185
nsv1071739 CNV deletion 25765185
nsv1071740 CNV deletion 25765185
nsv1071741 CNV deletion 25765185
nsv1072155 CNV deletion 25765185
nsv1072156 CNV deletion 25765185
nsv1072757 CNV deletion 25765185
nsv1073108 CNV deletion 25765185
nsv1073109 CNV deletion 25765185
nsv1073110 CNV deletion 25765185
nsv1073111 CNV deletion 25765185
nsv1078497 CNV duplication 25765185
nsv1109407 CNV deletion 24896259
nsv1114259 CNV deletion 24896259
nsv1116897 CNV deletion 24896259
nsv1123523 CNV deletion 24896259
nsv1123524 CNV deletion 24896259
nsv1123525 CNV deletion 24896259
nsv1136589 CNV deletion 24896259
nsv1136590 CNV deletion 24896259
nsv1136592 CNV deletion 24896259
nsv1136593 CNV deletion 24896259
nsv1138994 CNV deletion 24896259
nsv1138995 CNV deletion 24896259
nsv1138996 CNV deletion 24896259
nsv1138997 CNV deletion 24896259
nsv1143010 CNV tandem duplication 24896259
nsv1150038 CNV deletion 26484159
nsv1151660 CNV duplication 26484159
nsv3451 CNV insertion 18451855
nsv428382 CNV gain+loss 18775914
nsv435743 CNV deletion 17901297
nsv436329 CNV deletion 17901297
nsv436336 CNV deletion 17901297
nsv437841 CNV loss 16327808
nsv469643 CNV loss 16826518
nsv471421 CNV gain 19718026
nsv498974 CNV loss 21111241
nsv512628 CNV loss 21212237
nsv512629 CNV loss 21212237
nsv512630 CNV loss 21212237
nsv586978 CNV gain 21841781
nsv586979 CNV loss 21841781
nsv586980 CNV loss 21841781
nsv819478 CNV gain 19587683
nsv820736 CNV duplication 20802225
nsv828817 CNV gain 20364138
nsv828818 CNV gain 20364138
nsv834041 CNV gain 17160897
nsv953331 CNV duplication 24416366
nsv953332 CNV duplication 24416366
nsv954302 CNV deletion 24416366
nsv956736 CNV deletion 24416366
nsv964472 CNV duplication 23825009
nsv964473 CNV duplication 23825009
nsv965963 CNV duplication 23825009
nsv965965 CNV duplication 23825009
nsv965987 CNV duplication 23825009
nsv979515 CNV duplication 23825009
nsv9838 CNV gain+loss 18304495

Relevant External Links for BAGE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BAGE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for BAGE2 Gene

Disorders for BAGE2 Gene

Relevant External Links for BAGE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BAGE2

No disorders were found for BAGE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BAGE2 Gene

Publications for BAGE2 Gene

  1. New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. (PMID: 12461691) Ruault M. … De Sario A. (Eur. J. Hum. Genet. 2002) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. BAGE genes generated by juxtacentromeric reshuffling in the hominidae lineage are under selective pressure. (PMID: 12676563) Ruault M. … De Sario A. (Genomics 2003) 3 4 64
  4. Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms. (PMID: 12909339) Brun M.-E. … De Sario A. (Gene 2003) 3 22 64
  5. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PMID: 23936387) A9stensson M. … Torinsson-Naluai A.8. (PLoS ONE 2013) 3 64

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