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Aliases for BAGE2 Gene

Aliases for BAGE2 Gene

  • B Melanoma Antigen Family Member 2 2 3 5
  • B Melanoma Antigen Family, Member 2 2 3
  • Cancer/Testis Antigen 2.2 3 4
  • CT2.2 3 4
  • Cancer/Testis Antigen Family 2, Member 2 3
  • Cancer/Testis Antigen Family 2 2
  • Member 2 2

External Ids for BAGE2 Gene

Previous GeneCards Identifiers for BAGE2 Gene

  • GC21U990099
  • GC21M010043
  • GC21M010072
  • GC21M010996

Summaries for BAGE2 Gene

GeneCards Summary for BAGE2 Gene

BAGE2 (B Melanoma Antigen Family Member 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BAGE2 Gene

  • Unknown. Candidate gene encoding tumor antigens.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAGE2 Gene

Genomics for BAGE2 Gene

Regulatory Elements for BAGE2 Gene

Enhancers for BAGE2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BAGE2 on UCSC Golden Path with GeneCards custom track

Promoters for BAGE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BAGE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BAGE2 Gene

Chromosome:
21
Start:
10,413,477 bp from pter
End:
10,516,431 bp from pter
Size:
102,955 bases
Orientation:
Plus strand

Genomic View for BAGE2 Gene

Genes around BAGE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAGE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAGE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAGE2 Gene

Proteins for BAGE2 Gene

  • Protein details for BAGE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y30-BAGE2_HUMAN
    Recommended name:
    B melanoma antigen 2
    Protein Accession:
    Q86Y30
    Secondary Accessions:
    • A8K925
    • Q08ER0

    Protein attributes for BAGE2 Gene

    Size:
    109 amino acids
    Molecular mass:
    12114 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.

neXtProt entry for BAGE2 Gene

Proteomics data for BAGE2 Gene at MOPED

Post-translational modifications for BAGE2 Gene

No Post-translational modifications

Other Protein References for BAGE2 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for BAGE2 Gene

Domains & Families for BAGE2 Gene

Protein Domains for BAGE2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BAGE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y30

UniProtKB/Swiss-Prot:

BAGE2_HUMAN :
  • Belongs to the BAGE family.
Family:
  • Belongs to the BAGE family.
genes like me logo Genes that share domains with BAGE2: view

No data available for Gene Families for BAGE2 Gene

Function for BAGE2 Gene

Molecular function for BAGE2 Gene

UniProtKB/Swiss-Prot Function:
Unknown. Candidate gene encoding tumor antigens.
genes like me logo Genes that share phenotypes with BAGE2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BAGE2 Gene

Localization for BAGE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAGE2 Gene

Secreted.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for BAGE2 Gene

Pathways & Interactions for BAGE2 Gene

SuperPathways for BAGE2 Gene

No Data Available

Interacting Proteins for BAGE2 Gene

Gene Ontology (GO) - Biological Process for BAGE2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BAGE2 Gene

Drugs & Compounds for BAGE2 Gene

No Compound Related Data Available

Transcripts for BAGE2 Gene

mRNA/cDNA for BAGE2 Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BAGE2 Gene

No ASD Table

Relevant External Links for BAGE2 Gene

GeneLoc Exon Structure for
BAGE2
ECgene alternative splicing isoforms for
BAGE2

Expression for BAGE2 Gene

mRNA expression in normal human tissues for BAGE2 Gene

mRNA differential expression in normal tissues according to GTEx for BAGE2 Gene

This gene is overexpressed in Testis (x32.5) and Stomach (x6.7).

mRNA Expression by UniProt/SwissProt for BAGE2 Gene

Q86Y30-BAGE2_HUMAN
Tissue specificity: Not expressed in normal tissues except in testis. Expressed in 22% of melanomas, in bladder and lung carcinomas.
genes like me logo Genes that share expression patterns with BAGE2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BAGE2 Gene

Orthologs for BAGE2 Gene

Evolution for BAGE2 Gene

ENSEMBL:
Gene Tree for BAGE2 (if available)
TreeFam:
Gene Tree for BAGE2 (if available)

No data available for Orthologs for BAGE2 Gene

Paralogs for BAGE2 Gene

(4) SIMAP similar genes for BAGE2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BAGE2: view

No data available for Paralogs for BAGE2 Gene

Variants for BAGE2 Gene

Sequence variations from dbSNP and Humsavar for BAGE2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_059585 -
VAR_059586 -
rs283395 -- 10,431,567(+) tccgc(C/T)tgcct intron-variant
rs283396 -- 10,432,464(+) tcaag(C/T)aattc intron-variant
rs283397 -- 10,432,525(+) cctgg(C/T)ttatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAGE2 Gene

Variant ID Type Subtype PubMed ID
esv28756 CNV Gain+Loss 19812545
nsv428382 CNV Gain+Loss 18775914
dgv712n67 CNV Gain 20364138
esv32564 CNV Gain+Loss 17666407
esv29976 CNV Gain 17803354
nsv437841 CNV Loss 16327808
dgv1349e1 CNV Complex 17122850
esv720 CNV CNV 17122850
esv1000174 CNV Deletion 20482838
nsv436336 CNV Deletion 17901297
nsv512628 CNV Loss 21212237
esv2661615 CNV Deletion 23128226
esv991443 OTHER Inversion 20482838
nsv828817 CNV Gain 20364138
nsv469643 CNV Loss 16826518
dgv1350e1 CNV Complex 17122850
nsv834041 CNV Gain 17160897
nsv9838 CNV Gain+Loss 18304495
nsv820736 CNV Duplication 20802225
esv1008267 CNV Deletion 20482838
esv9537 CNV Loss 19470904
esv987944 CNV Deletion 20482838
nsv819478 CNV Gain 19587683
esv1008615 CNV Deletion 20482838
nsv828818 CNV Gain 20364138
nsv471421 CNV Duplication 19718026
esv1001067 CNV Insertion 20482838
nsv512629 CNV Loss 21212237
esv7291 CNV Loss 19470904
esv2563009 CNV Deletion 19546169
esv2675165 CNV Deletion 23128226
nsv435743 CNV Deletion 17901297
esv2474693 CNV Deletion 19546169
nsv436329 CNV Deletion 17901297
esv999403 CNV Deletion 20482838
nsv498974 CNV Loss 21111241
nsv3451 CNV Insertion 18451855
dgv73n16 CNV Deletion 17901297
nsv512630 CNV Loss 21212237
esv999554 CNV Insertion 20482838
esv1002199 CNV Deletion 20482838

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for BAGE2 Gene

Disorders for BAGE2 Gene

Relevant External Links for BAGE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BAGE2

No disorders were found for BAGE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BAGE2 Gene

Publications for BAGE2 Gene

  1. New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. (PMID: 12461691) Ruault M. … De Sario A. (Eur. J. Hum. Genet. 2002) 2 3 4 67
  2. Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms. (PMID: 12909339) Brun M.-E. … De Sario A. (Gene 2003) 3 23
  3. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PMID: 23936387) A9stensson M. … Torinsson-Naluai A.8. (PLoS ONE 2013) 3
  4. Gene dosage change of TPTE and BAGE2 and breakpoint analysis in Robertsonian Down syndrome. (PMID: 18074101) Shaw S.W. … Hsieh F.J. (J. Hum. Genet. 2008) 3
  5. The diploid genome sequence of an individual human. (PMID: 17803354) Levy S. … Venter J.C. (PLoS Biol. 2007) 3

Products for BAGE2 Gene

Sources for BAGE2 Gene

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