Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BAGE Gene

Aliases for BAGE Gene

  • B Melanoma Antigen 2 3 4
  • Cancer/Testis Antigen Family 2, Member 1 2 3
  • Cancer/Testis Antigen 2.1 3 4
  • Antigen MZ2-BA 3 4
  • BAGE1 3 4
  • CT2.1 3 4
  • B Melanoma Antigen 1 3

External Ids for BAGE Gene

Previous GeneCards Identifiers for BAGE Gene

  • GC21M007820
  • GC21M010080
  • GC21M010047
  • GC07M151408
  • GC21M010079
  • GC21M011000

Summaries for BAGE Gene

Entrez Gene Summary for BAGE Gene

  • This gene encodes a tumor antigen recognized by autologous cytolytic lymphocytes (CTL). [provided by RefSeq, Jul 2008]

GeneCards Summary for BAGE Gene

BAGE (B Melanoma Antigen) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BAGE Gene

  • Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAGE Gene

Genomics for BAGE Gene

Genomic Location for BAGE Gene

Chromosome:
21
Orientation:
Unknown strand

Genomic View for BAGE Gene


Cytogenetic band:
GeneLoc Logo Gene Density

No data available for Regulatory Elements and RefSeq DNA sequence for BAGE Gene

Proteins for BAGE Gene

  • Protein details for BAGE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13072-BAGE1_HUMAN
    Recommended name:
    B melanoma antigen 1
    Protein Accession:
    Q13072
    Secondary Accessions:
    • A4IF47

    Protein attributes for BAGE Gene

    Size:
    43 amino acids
    Molecular mass:
    4810 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21.

    Alternative splice isoforms for BAGE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAGE Gene

Post-translational modifications for BAGE Gene

No Post-translational modifications

Other Protein References for BAGE Gene

REFSEQ proteins:

No data available for DME Specific Peptides for BAGE Gene

Domains & Families for BAGE Gene

Protein Domains for BAGE Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BAGE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13072

UniProtKB/Swiss-Prot:

BAGE1_HUMAN :
  • Belongs to the BAGE family.
Family:
  • Belongs to the BAGE family.
genes like me logo Genes that share domains with BAGE: view

No data available for Gene Families for BAGE Gene

Function for BAGE Gene

Molecular function for BAGE Gene

UniProtKB/Swiss-Prot Function:
Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Phenotypes for BAGE Gene

GenomeRNAi human phenotypes for BAGE:
genes like me logo Genes that share phenotypes with BAGE: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BAGE Gene

Localization for BAGE Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAGE Gene

Secreted.

Gene Ontology (GO) - Cellular Components for BAGE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with BAGE: view

No data available for Subcellular locations from COMPARTMENTS for BAGE Gene

Pathways & Interactions for BAGE Gene

No Data Available

Interacting Proteins for BAGE Gene

Gene Ontology (GO) - Biological Process for BAGE Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BAGE Gene

Drugs & Compounds for BAGE Gene

(1) Additional Compounds for BAGE Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BAGE: view

Transcripts for BAGE Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAGE Gene

No ASD Table

Relevant External Links for BAGE Gene

ECgene alternative splicing isoforms for
BAGE

Expression for BAGE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BAGE Gene

Protein differential expression in normal tissues from HIPED for BAGE Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BAGE Gene



Protein tissue co-expression partners for BAGE Gene

NURSA nuclear receptor signaling pathways regulating expression of BAGE Gene:

BAGE

SOURCE GeneReport for Unigene cluster for BAGE Gene:

Hs.545789

mRNA Expression by UniProt/SwissProt for BAGE Gene:

Q13072-BAGE1_HUMAN
Tissue specificity: Not expressed in normal tissues, except in testis. Expressed with significant proportion in melanomas, but also in tumors of various histological origins, such as bladder carcinomas, head and neck squamous cell carcinomas, lung and breast carcinomas. Not expressed in renal, colorectal and prostatic carcinomas, leukemias and lymphomas. More frequently expressed in metastatic melanomas than in primary melanomas.
genes like me logo Genes that share expression patterns with BAGE: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BAGE Gene

Orthologs for BAGE Gene

No data available for Orthologs and Evolution for BAGE Gene

Paralogs for BAGE Gene

(4) SIMAP similar genes for BAGE Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BAGE: view

No data available for Paralogs for BAGE Gene

Variants for BAGE Gene

Structural Variations from Database of Genomic Variants (DGV) for BAGE Gene

Variant ID Type Subtype PubMed ID
nsv9838 CNV gain+loss 18304495
nsv979515 CNV duplication 23825009
nsv964473 CNV duplication 23825009
nsv954302 CNV deletion 24416366
nsv953332 CNV duplication 24416366
nsv953331 CNV duplication 24416366
nsv834041 CNV gain 17160897
nsv828818 CNV gain 20364138
nsv820736 CNV duplication 20802225
nsv586980 CNV loss 21841781
nsv586978 CNV gain 21841781
nsv512630 CNV loss 21212237
nsv512629 CNV loss 21212237
nsv512628 CNV loss 21212237
nsv498974 CNV loss 21111241
nsv471421 CNV gain 19718026
nsv469643 CNV loss 16826518
nsv437841 CNV loss 16327808
nsv436336 CNV deletion 17901297
nsv436329 CNV deletion 17901297
nsv435743 CNV deletion 17901297
nsv428382 CNV gain+loss 18775914
nsv3451 CNV insertion 18451855
nsv1151660 CNV duplication 26484159
nsv1150038 CNV deletion 26484159
nsv1143010 CNV tandem duplication 24896259
nsv1138997 CNV deletion 24896259
nsv1138996 CNV deletion 24896259
nsv1138995 CNV deletion 24896259
nsv1138994 CNV deletion 24896259
nsv1136593 CNV deletion 24896259
nsv1136592 CNV deletion 24896259
nsv1136590 CNV deletion 24896259
nsv1116897 CNV deletion 24896259
nsv1114259 CNV deletion 24896259
nsv1109407 CNV deletion 24896259
nsv1078497 CNV duplication 25765185
nsv1073111 CNV deletion 25765185
nsv1073110 CNV deletion 25765185
nsv1072757 CNV deletion 25765185
nsv1072156 CNV deletion 25765185
nsv1072155 CNV deletion 25765185
nsv1071741 CNV deletion 25765185
nsv1071740 CNV deletion 25765185
nsv1071739 CNV deletion 25765185
nsv1071738 CNV deletion 25765185
nsv1071408 CNV deletion 25765185
nsv1060052 CNV loss 25217958
nsv1059291 CNV loss 25217958
nsv1057510 CNV loss 25217958
esv999554 CNV insertion 20482838
esv999403 CNV deletion 20482838
esv991443 OTHER inversion 20482838
esv7291 CNV loss 19470904
esv3646371 CNV loss 21293372
esv3557434 CNV deletion 23714750
esv32564 CNV gain+loss 17666407
esv29976 CNV gain 17803354
esv28756 CNV gain+loss 19812545
esv2763681 CNV gain+loss 21179565
esv2760704 CNV gain 21179565
esv2758808 CNV gain+loss 17122850
esv2675165 CNV deletion 23128226
esv2661615 CNV deletion 23128226
esv2563009 CNV deletion 19546169
esv2474693 CNV deletion 19546169
esv1002199 CNV deletion 20482838
esv1001067 CNV insertion 20482838
esv1000174 CNV deletion 20482838
dgv7743n54 CNV gain 21841781
dgv7729n54 CNV gain 21841781
dgv7728n54 CNV gain 21841781
dgv73n16 CNV deletion 17901297
dgv712n67 CNV gain 20364138
dgv4373n100 CNV gain+loss 25217958
dgv4372n100 CNV loss 25217958
dgv4371n100 CNV gain 25217958
dgv4370n100 CNV loss 25217958
dgv4369n100 CNV gain 25217958
dgv4368n100 CNV gain+loss 25217958
dgv4367n100 CNV gain 25217958
dgv4363n100 CNV loss 25217958
dgv4358n100 CNV gain 25217958
dgv4356n100 CNV loss 25217958
dgv4355n100 CNV gain 25217958
dgv4354n100 CNV gain+loss 25217958
dgv2468e59 CNV duplication 20981092
dgv2354n106 CNV deletion 24896259
dgv2353n106 CNV deletion 24896259
dgv2352n106 CNV deletion 24896259
dgv2351n106 CNV deletion 24896259
dgv2349n106 CNV duplication 24896259

Relevant External Links for BAGE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BAGE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for BAGE Gene

Disorders for BAGE Gene

Relevant External Links for BAGE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BAGE

No disorders were found for BAGE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BAGE Gene

Publications for BAGE Gene

  1. BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. (PMID: 7895173) Boel P. … van der Bruggen P. (Immunity 1995) 2 3 4 22 64
  2. New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. (PMID: 12461691) Ruault M. … De Sario A. (Eur. J. Hum. Genet. 2002) 3 4 22 64
  3. Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines. (PMID: 20423514) Zhang S. … Yu Y. (BMC Cancer 2010) 3 22 64
  4. BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection. (PMID: 18541613) Grunau C. … De Sario A. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 22 64
  5. Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer. (PMID: 15704127) Grunau C. … De Sario A. (Genes Chromosomes Cancer 2005) 3 22 64

Products for BAGE Gene

Sources for BAGE Gene

Content
Loading form....