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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BAGE Gene

protein-coding   GIFtS: 33
GCID: GC21U900396

B Melanoma Antigen

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
B Melanoma Antigen1 2 3     Cancer/Testis Antigen Family 21
Antigen MZ2-BA2 3     Member 11
Cancer/Testis Antigen 2.12 3     B Melanoma Antigen 12
BAGE12 3     Cancer/Testis Antigen Family 2, Member 12
CT2.12 3     

External Ids:    HGNC: 9421   Entrez Gene: 5742   OMIM: 6051675   UniProtKB: Q130723   

Export aliases for BAGE gene to outside databases

Previous GC identifers: GC21M007820 GC21M010080 GC21M010047 GC07M151408 GC21M010079 GC21M011000


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BAGE Gene:
This gene encodes a tumor antigen recognized by autologous cytolytic lymphocytes (CTL). (provided by RefSeq, Jul
2008)

GeneCards Summary for BAGE Gene: 
BAGE (B melanoma antigen) is a protein-coding gene. Diseases associated with BAGE include bladder carcinoma, and testicular cancer.

UniProtKB/Swiss-Prot: BAGE1_HUMAN, Q13072
Function: Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for BAGE
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAGE


Genomic Location:
Chromosome:21   

Entrez Gene cytogenetic band: 21p11.1   HGNC cytogenetic band: 21p11.1

GeneLoc information about chromosome 21        


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BAGE1_HUMAN, Q13072 (See protein sequence)
Recommended Name: B melanoma antigen 1 precursor  
Size: 43 amino acids; 4810 Da
Subcellular location: Secreted (Potential)
Miscellaneous: The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The
BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of
expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene
fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18
and 21
Secondary accessions: A4IF47
Alternative splicing: 1 isoform:  Q13072-1   

Explore the universe of human proteins at neXtProt for BAGE: NX_Q13072

BAGE Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001178.1  
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

BAGE for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR012530 BAGE

Graphical View of Domain Structure for InterPro Entry Q13072

ProtoNet protein and cluster: Q13072

1 Blocks protein domain: IPB012530 B melanoma antigen

UniProtKB/Swiss-Prot: BAGE1_HUMAN, Q13072
Similarity: Belongs to the BAGE family


BAGE for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: BAGE1_HUMAN, Q13072
Function: Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BAGE

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BAGE for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BAGE (BAGE1)

1 Novoseek inferred chemical compound relationship for BAGE gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
5-aza-2'deoxycytidine 57.8 2 16734221 (1)

Search CenterWatch for drugs/clinical trials and news about BAGE / BAGE1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BAGE gene: 
NM_001187.1  

Unigene Clusters for BAGE:

B melanoma antigen
Hs.545789  [show with all ESTs], Hs.571595 , Hs.624543
Unigene Representative Sequences: AF527550, AF527554, AF527552
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Additional mRNA sequence: AF527552.1 

12 DOTS entries:

DT.91658794  DT.100696946  DT.91970370  DT.100700673  DT.100700674  DT.106361  DT.97794642  DT.121137683 
DT.91762451  DT.121049448  DT.121137656  DT.92338660 

24/366 AceView cDNA sequences (see all 366):

AI700911 AA599219 BM713197 AI370312 AK025553 BM702778 AI580958 BG059617 
AA811462 BE349960 AI418150 AI739379 AI915942 BU685177 AA433995 AA236552 
BM509873 BX280607 BU623509 AW007539 AA595504 BM696114 AA904457 AA121529 

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BAGE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAAACAAATT
BAGE Expression
About this image


Genevestigator expression for BAGE

SOURCE GeneReport for Unigene clusters: Hs.545789 Hs.571595 Hs.624543

UniProtKB/Swiss-Prot: BAGE1_HUMAN, Q13072
Tissue specificity: Not expressed in normal tissues, except in testis. Expressed with significant proportion in
melanomas, but also in tumors of various histological origins, such as bladder carcinomas, head and neck squamous
cell carcinomas, lung and breast carcinomas. Not expressed in renal, colorectal and prostatic carcinomas,
leukemias and lymphomas. More frequently expressed in metastatic melanomas than in primary melanomas

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAGE

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for BAGE gene
4 SIMAP similar genes for BAGE using alignment to 2 protein entries:     BAGE1_HUMAN (see all proteins):
BAGE5    BAGE4    BAGE2    BAGE3

BAGE for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
Structural Variations
     Database of Genomic Variants (DGV) 10/35 variations for BAGE (see all 35):    About this table     
Variant IDTypeSubtypePubMed ID
esv2563009CNV Deletion19546169
dgv73n16CNV Deletion17901297
esv2661615CNV Deletion23128226
nsv436329CNV Deletion17901297
esv2474693CNV Deletion19546169
esv2675165CNV Deletion23128226
esv999403CNV Deletion20482838
nsv435743CNV Deletion17901297
esv1002199CNV Deletion20482838
esv1000174CNV Deletion20482838

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605167    OMIM disorders: --

20 diseases for BAGE:    About MalaCards
bladder carcinoma    testicular cancer    melanoma    b-cell chronic lymphocytic leukemia
esophageal squamous cell carcinoma    hepatocellular carcinoma    peritonitis    chronic lymphocytic leukemia
rhabdomyosarcoma    liver disease    esophagitis    squamous cell carcinoma
colon cancer    myeloma    sarcoma    ovarian cancer
leukemia    prostatitis    adenocarcinoma    breast cancer


BAGE for disorders           About GeneDecksing

10 Novoseek inferred disease relationships for BAGE gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma 66.9 25 12461691 (3), 7895173 (2), 9650552 (2), 12676563 (1) (see all 12)
testicular cancer 51.3 2 9560255 (1), 12461691 (1)
bladder carcinoma 41.6 1 7895173 (1)
tumors 38.8 24 11391626 (3), 15704127 (2), 9209667 (2), 9434763 (2) (see all 14)
lung carcinoma 32.9 2 12461691 (1)
cancer 22 9 15704127 (3), 11391626 (2), 9740504 (1), 18541613 (1)
carcinoma 19.5 4 7895173 (1), 9816341 (1), 16475205 (1), 18541613 (1)
carcinoma squamous cell 16.1 4 11346870 (2), 7895173 (1), 16475205 (1)
hepatocellular carcinoma 6.3 2 10782910 (1), 14607688 (1)
metastasis 0 2 9650552 (2)


Export disorders for BAGE gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for BAGE gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with BAGE)
    Utopia: connect your pdf to the dynamic
world of online information

  1. BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. (PubMed id 7895173)1, 2, 3, 9 Boel P.... van der Bruggen P. (1995)
  2. New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. (PubMed id 12461691)1, 2, 9 Ruault M....De Sario A. (2002)
  3. Expression of tumor-specific antigen MAGE, GAGE and B AGE in ovarian cancer tissues and cell lines. (PubMed id 20423514)1, 9 Zhang S....Yu Y. (2010)
  4. BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection. (PubMed id 18541613)1, 9 Grunau C....De Sario A. (2008)
  5. Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer. (PubMed id 15704127)1, 9 Grunau C....De Sario A. (2005)
  6. BAGE genes generated by juxtacentromeric reshuffling in the Hominidae lineage are under selective pressure. (PubMed id 12676563)1, 9 Ruault M....De Sario A. (2003)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  8. mRNA detection of tumor-rejection genes BAGE, GAGE, and MAGE in peritoneal fluid from patients with ovarian carcinoma as a potential diagnostic tool. (PubMed id 12115308)1 Hofmann M. and Ruschenburg I. (2002)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. MAGE, BAGE and GAGE gene expression in human rhabdomyosarcomas. (PubMed id 11391626)9 Dalerba P....Zanovello P. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 574 HGNC: 942 AceView: MLL3 euGenes: HUgn574 ECgene: BAGE
H-InvDB: BAGE

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for BAGE Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BAGE Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for BAGE gene:
Search GeneIP for patents involving BAGE

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for BAGE
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BAGE
Customized:
 lentivirus for stable overexpression of BAGE
 lentivirus expression plasmids for stable overexpression of BAGE
 adenovirus for overexpression of BAGE
 Search LSBio for Antibodies for BAGE
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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