BAGE Gene
protein-coding GIFtS: 35
GCID: GC21M011000
|
|
B melanoma antigen
| |
Aliases
for BAGE gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| B Melanoma Antigen1 2 3 | | BAGE12 3 | | CT2.11 2 3 | | B Melanoma Antigen 12 | | Antigen MZ2-BA2 3 | | Cancer/Testis Antigen Family 2, Member 12 | | Cancer/Testis Antigen 2.12 3 | | |
Export aliases for BAGE gene to outside databasesPrevious GC identifers: GC21M007820 GC21M010080 GC21M010047 GC07M151408 GC21M010079 GC21U900396 |
Summaries
for BAGE gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BAGE:
This gene encodes a tumor antigen recognized by autologous cytolytic lymphocytes (CTL). (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: BAGE1_HUMAN, Q13072Function: Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes
|
Genomic Views
for BAGE gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for BAGE
Other transcription factors
Search SABiosciences Chromatin IP Primers for BAGE
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAGE |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21p11.1 HGNC cytogenetic band: 21p11.1BAGE Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21M011000: view genomic region
(about GC identifiers)
Start:
|
11,057,796 bp from pter |
End:
|
11,059,817 bp from pter |
Size:
|
2,022 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 151,297,621-151,299,632 |
|
Proteins
for BAGE gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BAGE1_HUMAN, Q13072 (See
protein sequence)Recommended Name: B melanoma antigen 1 precursor Size: 43 amino acids; 4810 Da
Subcellular location: Secreted (Potential)
Miscellaneous: The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3 gene. The BAGE familywas expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genesthat map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered inthe juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21
Secondary accessions: A4IF47Alternative splicing: 1 isoform: Q13072-1 Explore the universe of human proteins at neXtProt for BAGE: NX_Q13072
BAGE Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001178.1
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
BAGE for ontologies About GeneDecksing
BAGE Antibody Products:
Assay Products for BAGE: |
Protein
Domains /
Families
for BAGE gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BAGE for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q13072ProtoNet protein and cluster: Q13072 1 Blocks protein family: IPB012530 B melanoma antigen
UniProtKB/Swiss-Prot: BAGE1_HUMAN, Q13072Similarity: Belongs to the BAGE family |
Function
for BAGE gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BAGE1_HUMAN, Q13072Function: Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BAGE
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BAGE
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for BAGE | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAGE |
|
Pathways & Interactions
for BAGE gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BAGE
|
Drugs & Compounds
for BAGE gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
BAGE for compounds About GeneDecksing
 Browse Tocris compounds for BAGE
1 Novoseek chemical compound relationship for BAGE gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 5-aza-2'deoxycytidine |
57.8 |
2 |
16734221 (1) |
Search CenterWatch for drugs/clinical trials and news about BAGE / BAGE1
|
Transcripts
for BAGE gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BAGE gene: NM_001187.1 Unigene Clusters for BAGE: B melanoma antigen Hs.545789 [show with all ESTs], Hs.571595 , Hs.624543 Unigene Representative Sequences: AF527550, AF527554, AF527552
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BAGE
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BAGE
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BAGE (NM_001187) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BAGE | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAGE |
Additional cDNA sequence: AF527552.1 12 DOTS entries: DT.91658794 DT.100696946 DT.91970370 DT.100700673 DT.100700674 DT.106361 DT.97794642 DT.121137683 DT.91762451 DT.121049448 DT.121137656 DT.92338660 24/366 AceView cDNA sequences (see all 366): AI275540 CA396414 CB178817 BQ022717 BX954005 BU729354 AI418689 AI540051 AI362634 BM126876 AA127627 AA282356 CF272338 CA776966 CD513584 AI138511 AB040939 AA234595 BE674497 BM696114 AA236552 AA904457 AI370312 AK025553
GeneLoc Exon Structure
|
Expression
for BAGE gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BAGE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAACAAATT
About this image
Genevestigator expression for BAGE
SOURCE GeneReport for Unigene clusters: Hs.545789 Hs.571595 Hs.624543
UniProtKB/Swiss-Prot: BAGE1_HUMAN, Q13072Tissue specificity: Not expressed in normal tissues, except in testis. Expressed with significant proportion inmelanomas, but also in tumors of various histological origins, such as bladder carcinomas, head and neck squamous cellcarcinomas, lung and breast carcinomas. Not expressed in renal, colorectal and prostatic carcinomas, leukemias andlymphomas. More frequently expressed in metastatic melanomas than in primary melanomas
SABiosciences Custom PCR Arrays for BAGE
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat BAGE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BAGE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BAGE |
Orthologs
for BAGE gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
|
Paralogs
for BAGE gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for BAGE gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 21 variations for BAGE
15/21 CNVs (see all 21): 23086 79305 23321 35942 3224 22515 32434 7328 22855 90682 73600 5156 4109 31053 79306 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for BAGE gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BAGE for disorders About GeneDecksing
OMIM gene information: 605167
OMIM disorders: --
20/25  diseases for BAGE (see all 25): About MalaCardsmelanoma esophageal squamous cell carcinoma squamous cell carcinoma testicular cancer
chronic lymphocytic leukemia bladder carcinoma lymphocytic leukemia leukemia/lymphoma
carcinoma hepatocellular carcinoma liver disease rhabdomyosarcoma
ovarian carcinoma leukemia esophagitis colon cancer
ovarian cancer peritonitis prostate carcinoma breast carcinoma
10 Novoseek disease relationships for BAGE gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| melanoma |
66.9 |
25 |
12461691 (3), 7895173 (2), 9650552 (2), 12676563 (1) (see all 12) |
| testicular cancer |
51.3 |
2 |
9560255 (1), 12461691 (1) |
| bladder carcinoma |
41.6 |
1 |
7895173 (1) |
| tumors |
38.8 |
24 |
11391626 (3), 15704127 (2), 9209667 (2), 9434763 (2) (see all 14) |
| lung carcinoma |
32.9 |
2 |
12461691 (1) |
| cancer |
22 |
9 |
15704127 (3), 11391626 (2), 9740504 (1), 18541613 (1) |
| carcinoma |
19.5 |
4 |
7895173 (1), 9816341 (1), 16475205 (1), 18541613 (1) |
| carcinoma squamous cell |
16.1 |
4 |
11346870 (2), 7895173 (1), 16475205 (1) |
| hepatocellular carcinoma |
6.3 |
2 |
10782910 (1), 14607688 (1) |
| metastasis |
0 |
2 |
9650552 (2) |
Export disorders for BAGE gene to outside databases
|
Publications
for BAGE gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BAGE gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with BAGE) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. (PubMed id 7895173)1, 2, 3, 9 Boel P.... van der Bruggen P. (1995)
- New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. (PubMed id 12461691)1, 2, 9 Ruault M....De Sario A. (2002)
- Expression of tumor-specific antigen MAGE, GAGE and B AGE in ovarian cancer tissues and cell lines. (PubMed id 20423514)1, 9 Zhang S....Yu Y. (2010)
- BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection. (PubMed id 18541613)1, 9 Grunau C....De Sario A. (2008)
- Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer. (PubMed id 15704127)1, 9 Grunau C....De Sario A. (2005)
- BAGE genes generated by juxtacentromeric reshuffling in the Hominidae lineage are under selective pressure. (PubMed id 12676563)1, 9 Ruault M....De Sario A. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- mRNA detection of tumor-rejection genes BAGE, GAGE, and MAGE in peritoneal fluid from patients with ovarian carcinoma as a potential diagnostic tool. (PubMed id 12115308)1 Hofmann M. and Ruschenburg I. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- MAGE, BAGE and GAGE gene expression in human rhabdomyosarcomas. (PubMed id 11391626)9 Dalerba P....Zanovello P. (2001)
|
External Searches for BAGE gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BAGE gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BAGE gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BAGE gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for BAGE gene:
Search GeneIP for patents involving BAGE
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BAGE gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BAGE | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BAGE | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BAGE | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BAGE | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BAGE | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BAGE | | OriGene Custom Protein Services for BAGE | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BAGE | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BAGE | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAGE | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BAGE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BAGE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BAGE |
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| | | | Search Tocris compounds for BAGE |
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 | | | BAGE Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for BAGE |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAGE |
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