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BAGE Gene

protein-coding GIFtS: 38

GC21M010079

B melanoma antigen
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
BAGE1 ^², ³
CT2.1 ^¹, ², ³

Descriptions
Antigen MZ2-BA ^³
B melanoma antigen ^², ³
Cancer/testis antigen 2.1 ^³
cancer/testis antigen family 2, member 1 ^²

External Ids
HGNC: 942¹
Entrez Gene: 574²
UniProtKB: Q13072³

Search outside databases for aliases for BAGE gene

Previous GC identifers: GC21M007820 GC21M010080 GC21M010047 GC07M151408

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for BAGE:

This gene encodes a tumor antigen recognized by autologous cytolytic lymphocytes (CTL). [provided

by RefSeq]

UniProtKB/Swiss-Prot: BAGE1_HUMAN, Q13072

Function: Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BAGE gene

Entrez Gene cytogenetic band: 21p11.1 HGNC chromosome: 13

BAGE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

GeneLoc location for GC21M010079: (about GC identifiers)

Start:	10,079,667 bp from pter
End:	10,120,808 bp from pter
Size:	41,142 bases
Orientation:	minus strand

BAGE has overlapping exons with:

BAGE4

RefSeq DNA sequence:

NC_000021.7 NT_029490.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BAGE1_HUMAN, Q13072 (See protein sequence)

Recommended Name: B melanoma antigen 1 precursor

Size: 43 amino acids; 4810 Da

Subcellular location: Secreted (Potential)

Miscellaneous: The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the MLL3

gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE

family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13

and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several

chromosomes, including chromosomes 9, 13, 18 and 21

Secondary accessions: A4IF47

Alternative splicing: 1 isoform: Q13072-1 (At least 6 different mRNAs, BAGE1a, BAGE1b, BAGE1c, BAGE1d, BAGE1e and BAGE1f, are produced by alternative splicing. They differ in the 3' region, but give rise to the same protein sequence)

REFSEQ proteins: NP_001178.1
Human Recombinant Proteins

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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

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Antibodies for BAGE:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for BAD

Assays for BAGE:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13072

ProtoNet protein and cluster: Q13072

1 Blocks protein family: IPB012530 B melanoma antigen

UniProtKB/Swiss-Prot: BAGE1_HUMAN, Q13072

Similarity: Belongs to the BAGE family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001187

Applied Biosystems Silencer® siRNAs for BAGE

Sigma-Aldrich siRNA for BAGE

Sigma-Aldrich shRNA for BAGE

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001187
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001187
untagged cDNA clone in CMV expression vector: NM_001187

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001187

UniProtKB/Swiss-Prot: BAGE1_HUMAN, Q13072

Function: Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BAGE

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001187

Sigma-Aldrich siRNA for BAGE

Sigma-Aldrich shRNA for BAGE

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001187

REFSEQ mRNAs for BAGE gene:

NM_001187.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001187

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001187
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001187
                                 untagged cDNA clone in CMV expression vector: NM_001187

Additional cDNA sequence: AF527552.1

11 DOTS entries:

DT.91658794 DT.100696946 DT.91970370 DT.100700673 DT.100700674 DT.106361 DT.97794642 DT.121137683

DT.91762451 DT.121049448 DT.92338660

24/366 AceView cDNA sequences (see all 366 ):

BX952086 AI540051 BX641294 AA595504 AA116096 AW007539 AA282237 NM_021230

BM509873 AI640514 AA599219 AI275540 AL698915 BE674497 BQ434831 BX954005

AI636190 AW263143 BM557373 AI580958 AW999286 AI247296 AI362634 AA811462

highest scoring ESTs for BAGE:

AF527554 U19180 AF527551 AF527553 AA759259 AW295110 BC107038 BE463879 BE592061 BF874397

Unigene Clusters for BAGE:

B melanoma antigen

Hs.545789 [show with all ESTs], Hs.624542 , Hs.624543

Unigene Representative Sequences: AF527550, AF527554, AF527552

GeneLoc Exon Structure

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BAGE expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BAGE

¹ / ² / ³

6 probe-sets matching BAGE gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1037_at²^{, 3}	U95-A	6	1.00	0.54	1.00	1.00	U19180	0.80	0.70	0.75	1
207712_at²^{, 3}	U133-A	6	1.00	0.65	--	--	NM_001187	0.40	0.67	0.55	1
1555603_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555605_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555369_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207712_at²	U133Plus2	6	1.00	0.65	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAAACAAATT

SOURCE GeneReport for Unigene clusters: Hs.545789 Hs.624542 Hs.624543
Expression variation in blood from EXPOLDB for BAGE
UniProtKB/Swiss-Prot: BAGE1_HUMAN, Q13072
Tissue specificity: Not expressed in normal tissues, except in testis. Expressed with significant
proportion in melanomas, but also in tumors of various histological origins, such as bladder
carcinomas, head and neck squamous cell carcinomas, lung and breast carcinomas. Not expressed in
renal, colorectal and prostatic carcinomas, leukemias and lymphomas. More frequently expressed in
metastatic melanomas than in primary melanomas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605167

10 Novoseek disease relationships for BAGE gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma	67.94	25	12461691 (3), 7895173 (2), 9650552 (2), 12676563 (1) (see all 12)
testicular cancer	52.53	2	9560255 (1), 12461691 (1)
bladder carcinoma	42.58	1	7895173 (1)
tumors	39.03	24	11391626 (3), 15704127 (2), 9209667 (2), 9434763 (2) (see all 14)
lung carcinoma	34.07	2	12461691 (1)
cancer	24.09	9	15704127 (3), 11391626 (2), 9740504 (1), 18541613 (1)
carcinoma	20.78	4	7895173 (1), 9816341 (1), 16475205 (1), 18541613 (1)
carcinoma squamous cell	17.78	4	11346870 (2), 7895173 (1), 16475205 (1)
hepatocellular carcinoma	8.25	2	10782910 (1), 14607688 (1)
metastasis	0.00	2	9650552 (2)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/33 PubMed articles for BAGE gene (see all 33 ):

BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. (PubMed id 7895173)^{1, 2, 3, 4} Boel P.... van der Bruggen P. (1995)
New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. (PubMed id 12461691)^{1, 3, 4} Ruault M....De Sario A. (2002)
BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection. (PubMed id 18541613)^{1, 3} Grunau C....De Sario A. (2008)
Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer. (PubMed id 15704127)^{1, 3} Grunau C....De Sario A. (2005)
BAGE genes generated by juxtacentromeric reshuffling in the Hominidae lineage are under selective pressure. (PubMed id 12676563)^{1, 3} Ruault M....De Sario A. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
mRNA detection of tumor-rejection genes BAGE, GAGE, and MAGE in peritoneal fluid from patients with ovarian carcinoma as a potential diagnostic tool. (PubMed id 12115308)³ Hofmann M. and Ruschenburg I. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
MAGE, BAGE and GAGE gene expression in human rhabdomyosarcomas. (PubMed id 11391626)¹ Dalerba P....Zanovello P. (2001)
Expression of MAGE and BAGE genes in Japanese breast cancers. (PubMed id 9209667)¹ Fujie T....Akiyoshi T. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 574	HGNC: 942	AceView: MLL3	euGenes: HUgn574	ECgene: BAGE
H-InvDB: BAGE

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BAGE	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for BAGE
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BAGE:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BAGE-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BAGE		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BAGE		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for BAGE

Search Tocris compounds for BAGE

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BAD

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BAGE Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for BAGE

Summaries
for BAGE

Genomic Location
for BAGE

Proteins
for BAGE

Protein Domains/
Families
for BAGE

Gene Function
for BAGE

Pathways & Interactions
for BAGE

Drugs & Compounds
for BAGE

Transcripts
for BAGE

Expression
for BAGE

Orthologs
for BAGE

Paralogs
for BAGE

SNPs/Variants
for BAGE

Disorders & Mutations
for BAGE

Medical News
for BAGE

Publications
for BAGE

Search for BAGE

Genome Databases showing BAGE

Other Databases showing BAGE

Specialized Databases showing BAGE

Licensable Technologies
for BAGE

Services
for BAGE

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BAGE Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor BAGE

Summariesfor BAGE

Genomic Locationfor BAGE

Proteinsfor BAGE

Protein Domains/Familiesfor BAGE

Gene Functionfor BAGE

Pathways & Interactionsfor BAGE

Drugs & Compoundsfor BAGE

Transcriptsfor BAGE

Expression for BAGE

Orthologsfor BAGE

Paralogsfor BAGE

SNPs/Variantsfor BAGE

Disorders & Mutationsfor BAGE

Medical Newsfor BAGE

Publicationsfor BAGE

Search for BAGE

Genome Databases showing BAGE

Other Databases showing BAGE

Specialized Databases showing BAGE

Licensable Technologiesfor BAGE

Servicesfor BAGE

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BAGE

Summaries
for BAGE

Genomic Location
for BAGE

Proteins
for BAGE

Protein Domains/
Families
for BAGE

Gene Function
for BAGE

Pathways & Interactions
for BAGE

Drugs & Compounds
for BAGE

Transcripts
for BAGE

Expression
for BAGE

Orthologs
for BAGE

Paralogs
for BAGE

SNPs/Variants
for BAGE

Disorders & Mutations
for BAGE

Medical News
for BAGE

Publications
for BAGE

Licensable Technologies
for BAGE

Services
for BAGE