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Aliases for BAGE Gene

Aliases for BAGE Gene

  • B Melanoma Antigen 2 3 4
  • Cancer/Testis Antigen 2.1 3 4
  • Antigen MZ2-BA 3 4
  • BAGE1 3 4
  • CT2.1 3 4
  • Cancer/Testis Antigen Family 2, Member 1 3
  • Cancer/Testis Antigen Family 2 2
  • B Melanoma Antigen 1 3
  • Member 1 2

External Ids for BAGE Gene

Previous GeneCards Identifiers for BAGE Gene

  • GC21M007820
  • GC21M010080
  • GC21M010047
  • GC07M151408
  • GC21M010079
  • GC21M011000

Summaries for BAGE Gene

Entrez Gene Summary for BAGE Gene

  • This gene encodes a tumor antigen recognized by autologous cytolytic lymphocytes (CTL). [provided by RefSeq, Jul 2008]

GeneCards Summary for BAGE Gene

BAGE (B Melanoma Antigen) is a Protein Coding gene. Diseases associated with BAGE include testicular cancer and chronic lymphocytic leukemia.

UniProtKB/Swiss-Prot for BAGE Gene

  • Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAGE Gene

Genomics for BAGE Gene

Genomic Location for BAGE Gene

Orientation:
Unknown strand

Genomic View for BAGE Gene

Cytogenetic band:
  • 21p11.1 not on reference assembly by Entrez Gene
  • 21p11.1 not on reference assembly by HGNC

No data available for Regulatory Elements and RefSeq DNA sequence for BAGE Gene

Proteins for BAGE Gene

  • Protein details for BAGE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13072-BAGE1_HUMAN
    Recommended name:
    B melanoma antigen 1
    Protein Accession:
    Q13072
    Secondary Accessions:
    • A4IF47

    Protein attributes for BAGE Gene

    Size:
    43 amino acids
    Molecular mass:
    4810 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The ancestral BAGE gene was generated by juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family was expanded by juxtacentromeric movement and/or acrocentric exchanges. BAGE family is composed of expressed genes that map to the juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed gene fragments that scattered in the juxtacentromeric regions of several chromosomes, including chromosomes 9, 13, 18 and 21

    Alternative splice isoforms for BAGE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAGE Gene

Proteomics data for BAGE Gene at MOPED

Post-translational modifications for BAGE Gene

No Post-translational modifications

Other Protein References for BAGE Gene

REFSEQ proteins:

No data available for DME Specific Peptides for BAGE Gene

Domains for BAGE Gene

Protein Domains for BAGE Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BAGE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13072

UniProtKB/Swiss-Prot:

BAGE1_HUMAN :
  • Q13072
Family:
  • Belongs to the BAGE family.
genes like me logo Genes that share domains with BAGE: view

No data available for Gene Families for BAGE Gene

Function for BAGE Gene

Molecular function for BAGE Gene

UniProtKB/Swiss-Prot Function: Unknown. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BAGE

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BAGE Gene

Localization for BAGE Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAGE Gene

Secreted.

Gene Ontology (GO) - Cellular Components for BAGE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with BAGE: view

No data available for Subcellular locations from COMPARTMENTS for BAGE Gene

Pathways for BAGE Gene

SuperPathways for BAGE Gene

No Data Available

Interacting Proteins for BAGE Gene

Gene Ontology (GO) - Biological Process for BAGE Gene

None

No data available for Pathways by source for BAGE Gene

Compounds for BAGE Gene

(1) Novoseek inferred chemical compound relationships for BAGE Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 57.8 1
genes like me logo Genes that share compounds with BAGE: view

Transcripts for BAGE Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BAGE

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAGE Gene

No ASD Table

Relevant External Links for BAGE Gene

ECgene alternative splicing isoforms for
BAGE

Expression for BAGE Gene

mRNA expression in normal human tissues for BAGE Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for BAGE Gene

SOURCE GeneReport for Unigene cluster for BAGE Gene Hs.545789

mRNA Expression by UniProt/SwissProt for BAGE Gene

Q13072-BAGE1_HUMAN
Tissue specificity: Not expressed in normal tissues, except in testis. Expressed with significant proportion in melanomas, but also in tumors of various histological origins, such as bladder carcinomas, head and neck squamous cell carcinomas, lung and breast carcinomas. Not expressed in renal, colorectal and prostatic carcinomas, leukemias and lymphomas. More frequently expressed in metastatic melanomas than in primary melanomas
genes like me logo Genes that share expressions with BAGE: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BAGE Gene

Orthologs for BAGE Gene

No data available for Orthologs and Evolution for BAGE Gene

Paralogs for BAGE Gene

Selected SIMAP similar genes for BAGE Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BAGE: view

No data available for Paralogs for BAGE Gene

Variants for BAGE Gene

Structural Variations from Database of Genomic Variants (DGV) for BAGE Gene

Variant ID Type Subtype PubMed ID
esv28756 CNV Gain+Loss 19812545
nsv428382 CNV Gain+Loss 18775914
dgv712n67 CNV Gain 20364138
esv32564 CNV Gain+Loss 17666407
esv29976 CNV Gain 17803354
nsv437841 CNV Loss 16327808
dgv1349e1 CNV Complex 17122850
esv720 CNV CNV 17122850
esv1000174 CNV Deletion 20482838
nsv436336 CNV Deletion 17901297
nsv512628 CNV Loss 21212237
esv2661615 CNV Deletion 23128226
esv991443 OTHER Inversion 20482838
nsv469643 CNV Loss 16826518
dgv1350e1 CNV Complex 17122850
nsv834041 CNV Gain 17160897
nsv9838 CNV Gain+Loss 18304495
nsv820736 CNV Duplication 20802225
nsv828818 CNV Gain 20364138
nsv471421 CNV Duplication 19718026
esv1001067 CNV Insertion 20482838
nsv512629 CNV Loss 21212237
esv7291 CNV Loss 19470904
esv2563009 CNV Deletion 19546169
esv2675165 CNV Deletion 23128226
nsv435743 CNV Deletion 17901297
esv2474693 CNV Deletion 19546169
nsv436329 CNV Deletion 17901297
esv999403 CNV Deletion 20482838
nsv498974 CNV Loss 21111241
nsv3451 CNV Insertion 18451855
dgv73n16 CNV Deletion 17901297
nsv512630 CNV Loss 21212237
esv999554 CNV Insertion 20482838
esv1002199 CNV Deletion 20482838

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for BAGE Gene

Disorders for BAGE Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for BAGE Gene including...

Search for BAGE Gene in MalaCards »

(10) Novoseek inferred disease relationships for BAGE Gene

Disease -log(P) Hits PubMed IDs
melanoma 66.9 16
testicular cancer 51.3 2
bladder carcinoma 41.6 1
tumors 38.8 20
lung carcinoma 32.9 1
genes like me logo Genes that share disorders with BAGE: view

No data available for UniProtKB/Swiss-Prot for BAGE Gene

Publications for BAGE Gene

  1. BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. (PMID: 7895173) Boel P. … van der Bruggen P. (Immunity 1995) 2 3 4 23
  2. New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. (PMID: 12461691) Ruault M. … De Sario A. (Eur. J. Hum. Genet. 2002) 3 4 23
  3. BAGE genes generated by juxtacentromeric reshuffling in the hominidae lineage are under selective pressure. (PMID: 12676563) Ruault M. … De Sario A. (Genomics 2003) 3 23
  4. Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer. (PMID: 15704127) Grunau C. … De Sario A. (Genes Chromosomes Cancer 2005) 3 23
  5. BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection. (PMID: 18541613) Grunau C. … De Sario A. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 23

Products for BAGE Gene

Sources for BAGE Gene

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