BAG5 Gene
protein-coding GIFtS: 53
GCID: GC14M104022
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BCL2-associated athanogene 5
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Aliases
for BAG5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BCL2-Associated Athanogene 51 2 | | Bcl-2-Associated Athanogene 52 3 | | BAG-52 3 | | BAG Family Molecular Chaperone Regulator 52 | | BAG-Family Molecular Chaperone Regulator-52 | | KIAA08733 |
Export aliases for BAG5 gene to outside databasesPrevious GC identifers: GC14M101414 GC14M097838 GC14M102013 GC14M103093 GC14M084201 |
Summaries
for BAG5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BAG5:
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein thatfunctions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2,Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDafamily. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity ofHsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15Function: Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity).May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediatedrefolding
Gene Wiki entry for BAG5
|
Genomic Views
for BAG5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BAG5 gene promoter:
PPAR-alpha AREB6 Nkx2-2 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for BAG5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAG5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.33 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32BAG5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M104022: view genomic region
(about GC identifiers)
Start:
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104,022,881 bp from pter |
End:
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104,029,168 bp from pter |
Size:
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6,288 bases |
Orientation:
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minus strand |
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Proteins
for BAG5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15 (See
protein sequence)Recommended Name: BAG family molecular chaperone regulator 5 Size: 447 amino acids; 51200 Da
Subunit: Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PARK2 (By similarity)
Sequence caution: Sequence=BAA74896.1; Type=Erroneous initiation;
2 PDB 3D structures from  and Proteopedia  for BAG5:2D9D (3D)
3A8Y (3D)
Secondary accessions: O94950 Q86W59Alternative splicing: 2 isoforms: Q9UL15-1 Q9UL15-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for BAG5: NX_Q9UL15
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UL15
BAG5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001015048.1 NP_001015049.1 NP_004864.1
ENSEMBL proteins: ENSP00000391713 ENSP00000338814 ENSP00000450497 ENSP00000299204
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
BAG5 for ontologies About GeneDecksing
BAG5 Antibody Products:
Assay Products for BAG5: |
Protein
Domains /
Families
for BAG5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BAG5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UL15ProtoNet protein and cluster: Q9UL15 1 Blocks protein family: IPB003103 Apoptosis regulator Bcl-2 protein
UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15Domain: The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domainSimilarity: Contains 5 BAG domains |
Function
for BAG5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15Function: Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity).May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediatedrefolding Genatlas biochemistry entry for BAG5:BCL2-associated athanogene 5 (antiapoptotic). Negative regulator of Hsp70 chaperone activity
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BAG5 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for BAG5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAG5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAG5 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
BAG5 for ontologies About GeneDecksing
|
Pathways & Interactions
for BAG5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BAG5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/18 Interacting proteins for BAG5 (Q9UL152, 3 ENSP000003388144) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
BAG5 for ontologies About GeneDecksing
|
Drugs & Compounds
for BAG5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BAG5
Search CenterWatch for drugs/clinical trials and news about BAG5
|
Transcripts
for BAG5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BAG5 gene (3 alternative transcripts): NM_001015048.2 NM_001015049.2 NM_004873.3 Unigene Cluster for BAG5: BCL2-associated athanogene 5 Hs.5443 [show with all ESTs]Unigene Representative Sequence: NM_0010150494 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000445922(uc001yni.2 uc001ynh.2) ENST00000337322 ENST00000557666
ENST00000299204(uc001ynj.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BAG5 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BAG5 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): BAG5 (NM_001015048) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BAG5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAG5 |
Additional cDNA sequence: AB020680.1 AF095195.2 AK001378.1 AK023145.1 AK225730.1 AK225741.1 AK291312.1 BC044216.1 BC050551.1 11 DOTS entries: DT.99986185 DT.95081860 DT.452049 DT.120790950 DT.120790749 DT.40189856 DT.100792714 DT.120790876 DT.100792711 DT.100792712 DT.120790743 24/208 AceView cDNA sequences (see all 208): BP369850 AA604411 AL701774 AA427573 AA457021 AI457485 CA424706 AI200808 BM793091 BX956841 BC050551 AW673909 AI347659 CA455194 AA456862 AL709127 AW591824 AF095195 AI457217 AW675074 AI272932 BP369135 BC044216 AU140146
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for BAG5 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c |
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| SP1: | | | - | | - | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for BAG5
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Expression
for BAG5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BAG5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTAATATA
About this image
See BAG5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BAG5
SOURCE GeneReport for Unigene cluster: Hs.5443
SABiosciences Expression via Pathway-Focused PCR Array including BAG5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BAG5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BAG5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BAG5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BAG5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAG5 |
Orthologs
for BAG5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for BAG5 gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for BAG5 (if available)
TreeFam Gene Tree for BAG5 (if available) |
Paralogs
for BAG5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BAG5 gene
- BAG42 BAG32
BAG5 for paralogs About GeneDecksing
|
Genomic Variants
for BAG5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BAG5 (104022881 - 104029168 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BAG5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BAG5 |
|
Disorders
/ Diseases
for BAG5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BAG5 for disorders About GeneDecksing
OMIM gene information: 603885
OMIM disorders: --
5  diseases for BAG5: About MalaCardsnon-hodgkin lymphoma hodgkin's lymphoma toxoplasmosis parkinson's disease
neuronitis
Human Genome Epidemiology (HuGE) Navigator: BAG5 (5 documents)
Export disorders for BAG5 gene to outside databases
|
Publications
for BAG5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BAG5 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with BAG5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PubMed id 9873016)1, 2, 3, 9 Takayama S.... Reed J.C. (1999)
- BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. (PubMed id 15603737)1, 3 Kalia S.K....Lozano A.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Ubiquitinylation of I+-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5). (PubMed id 21358815)1 Kalia L.V....McLean P.J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1 Zhang X....Wu X. (2010)
- Germline variation in apoptosis pathway genes and ris k of non-Hodgkin's lymphoma. (PubMed id 20855536)1 Kelly J.L....Cerhan J.R. (2010)
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External Searches for BAG5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BAG5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BAG5 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing BAG5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BAG5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BAG5 gene:
Search GeneIP for patents involving BAG5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BAG5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for BAG5 | | OriGene shRNA RFP for BAG5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BAG5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BAG5 | | | OriGene Protein Over-expression Lysate for BAG5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BAG5 | | OriGene 3'-UTR Clone for BAG5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BAG5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BAG5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for BAG5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BAG5 | | OriGene Custom Protein Services for BAG5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BAG5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BAG5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAG5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BAG5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BAG5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BAG5 |
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| |  |  |  |  | | | | |
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 | | | BAG5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAG5 |
|  |  |  | | | | ThermoFisher Antibodies for BAG5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAG5 |
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