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BAG5 Gene

protein-coding   GIFtS: 57

GC14M103093
BCL2-associated athanogene 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
BAG-5 2, 3
KIAA0873 3
Descriptions
BAG-family molecular chaperone regulator-5 2
BCL2-associated athanogene 5 2
Bcl-2-associated athanogene 5 3
External Ids
HGNC: 9411
Entrez Gene: 95292
UniProtKB: Q9UL153
Ensembl: ENSG000001661707
Search outside databases for aliases for BAG5 gene

Previous GC identifers: GC14M101414 GC14M097838 GC14M102013

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for BAG5:
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an
anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and
growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth
factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG
domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70.
Three transcript variants encoding two different isoforms have been found for this gene. [provided
by RefSeq]

UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15
Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits
both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity)

Gene Wiki entry for BAG5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BAG5 gene  

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32

BAG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M103093:     (about GC identifiers)

Start:
103,092,642 bp from pter
End:
103,098,904 bp from pter
Size:
6,263 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15 (See protein sequence)
Recommended Name: BAG family molecular chaperone regulator 5  
Size: 447 amino acids; 51200 Da
Subunit: Binds to the ATPase domain of HSP70/HSC chaperones. Binds PARK2 (By similarity)
PDB structures from and Proteopedia :
2D9D (3D)    
Secondary accessions: O94950 Q86W59

REFSEQ proteins (3 alternative transcripts): 
NP_001015048.1  NP_001015049.1  NP_004864.1  


ENSEMBL proteins: 
ENSP00000338814 ENSP00000299204 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Bag5)
Human Recombinant Proteins from Abnova (BAG5)
              OriGene Purified Recombinant Human Protein: BAG5 


Antibodies for BAG5: 
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Sigma-Aldrich Antibodies for BAG5
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Antibodies from Abcam (Bag5), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (BAG5)
Novus Biologicals Antibodies for BAG5

Assays for BAG5: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR003103 Apoptosis_reg_Bcl-2_prot_BAG


   GeneDecks  BAG5 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9UL15

ProtoNet protein and cluster: Q9UL15

1 Blocks protein family: IPB003103 Apoptosis regulator Bcl-2 protein

UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15
Similarity: Contains 4 BAG domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (BAG5)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (BAG5)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001015048

              Applied Biosystems Silencer® siRNAs for BAG5

              Sigma-Aldrich siRNA for BAG5  
                     Sigma-Aldrich shRNA Panels and shRNA for BAG5  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for BAG5
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001015048
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001015048
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001015048 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001015049

UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15
Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits
both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity)

Genatlas biochemistry entry for BAG5:
BCL2-associated athanogene 5 (antiapoptotic). Negative regulator of Hsp70 chaperone activity

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  BAG5 


5/18 Interacting proteins for BAG5 (ENSP000003388143 Q9UL152) via UniProtKB, MINT, and/or STRING (see all 18 )
InteractantInteraction Details
GeneCardExternal ID(s)
MAP3K1Q132332MINT-48282
MAP3K3Q997592MINT-48391
BAG1ENSP000002241123STRING (score=.931)
HSPA4ENSP000003029613STRING (score=.93)
BAG2ENSP000003597273STRING (score=.923)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006457 protein folding TAS9873016
GO:0006915 apoptosis IEA--
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BAG5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (BAG5)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (BAG5)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001015048

              Sigma-Aldrich siRNA for BAG5  
                     Sigma-Aldrich shRNA Panels and shRNA for BAG5  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001015048  NM_001015049  NM_004873  

REFSEQ mRNAs for BAG5 gene (3 alternative transcripts): 

NM_001015048.1   NM_001015049.1   NM_004873.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001015048  NM_001015049  NM_004873  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001015048
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001015048
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001015048 

Additional cDNA sequence: 

AB020680.1 AF095195.2 AK001378.1 AK023145.1 AK225730.1 AK225741.1 AK291312.1 BC044216.1 
BC050551.1 

11 DOTS entries:

DT.99986185  DT.95081860  DT.452049  DT.120790950  DT.120790749  DT.40189856  DT.100792714  DT.120790876 
DT.100792711  DT.100792712  DT.120790743 

24/208 AceView cDNA sequences (see all 208 ):

AI457485 AW069057 BM452522 AL701774 AI200808 CA420231 AB020680 AA427991 
AA456862 AW591824 AI368884 AA457021 W15295 AI701102 CN482320 AW129332 
AI272932 AW673909 BQ223297 BX956841 BG413412 AA604411 BC050551 AL709127 

highest scoring ESTs for BAG5:

AB020680 AI929707 AL701774 AL709127 AL711196 AU279920 AW129332 AW295053 BE041589 BF941752 

Unigene Cluster for BAG5:

BCL2-associated athanogene 5
Hs.5443  [show with all ESTs]
Unigene Representative Sequence: NM_001015049


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for BAG5

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1:        -     -     -                     
SP2:                    -                     
SP3:                                          

About this scheme

ECgene alternative splicing isoforms for BAG5

2 Ensembl transcripts including schematic representations:
ENST00000337322  ENST00000299204  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BAG5 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for BAG5

1 / 2 / 3

8 probe-sets matching BAG5 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

36463_at2, 3 U95-A 1 1.00 1.00 0.75 1.17 AB020680 1.00 1.00 1.00 1
57702_at2, 3 U95-C 1 1.00 1.00 0.99 0.85 AI142838 0.60 1.00 0.82 1

230427_s_at2, 3 U133-B 1 1.00 1.00 -- -- AW673909 0.40 1.00 0.76 1

202984_s_at2, 3 U133-A 1 1.00 1.00 -- -- AA457021 0.60 1.00 0.82 1

202985_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004873 0.60 1.00 0.82 1

230427_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

202984_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

202985_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  BAG5 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TGTTAATATA

SOURCE GeneReport for Unigene cluster: Hs.5443

Expression variation in blood from EXPOLDB for BAG5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for BAG5 gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
BAG51   -- BCL2-associated athanogene 5 90.13(n)
96.27(a)
480444  XM_537562.2  XP_537562.2 
cow
(Bos taurus)
BAG51   -- BCL2-associated athanogene 5 87.47(n)
93.74(a)
522854  NM_001040544.1  NP_001035634.1 
rat
(Rattus norvegicus)
Bag51   -- BCL2-associated athanogene 5 84.94(n)
90.83(a)
366734  NM_001008526.2  NP_001008526.1 
mouse
(Mus musculus)
Bag51, 5 125
BCL2-associated athanogene 51, 5 83.82(n)1
91.28(a)1
703691  NM_027404.11  NP_081680.11 
 AI6632835  AK0055345  (see all 10)
chicken
(Gallus gallus)
BAG51   -- BCL2-associated athanogene 5 73.75(n)
79.87(a)
423482  NM_001031211.1  NP_001026382.1 
About this table        Species with no ortholog for BAG5

ENSEMBL Gene Tree for BAG5
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for BAG5 gene
BAG42  BAG32  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/18 NCBI SNPs in BAG5 are shown (see all 18 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 31)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 14 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs76931,2
A,C,F,H,O103093457(+) GAAACC/TAGAAA 3 -- ut31 ese310Minor allele frequency- T:0.22MN EU EA WA 1208
rs71549481,2
A,C,F,H103092697(+) ATTAAC/TACATG 3 -- ut314Minor allele frequency- T:0.25EU EA WA 400
--
rs71545871,2
A,C103092503(+) gatcgC/Tgctat 3 -- ng510--------
rs354985761,2
F103095646(+) TATTTT/CGTTTT 3 -- ut312Minor allele frequency- C:0.33NA 182
--
rs351961351,2
--103092903(+) AAAAA-/CCCCAA 3 -- ut310--------
--
rs718643821,2
--103092553(+) AAAAA-/AAAAAA 3 -- ng510--------
--
rs359707041,2
--103092886(+) GCTCA-/AAAAAA 3 -- ut310--------
--
rs671800981,2
--103092564(+) AAAAG-/AGGCTC 3 -- ng510--------
--
rs356549951,2
--103095091(+) TTTCC-/TTTTTT 3 -- ut310--------
--
rs344820441,2
--103092546(+) GTCTC-/AAAAAAA 3 -- ng510--------
About this table

HapMap Linkage Disequilibrium images for BAG5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603885

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/11 PubMed articles for BAG5 gene (see all 11 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9529 HGNC: 941 AceView: BAG5 Ensembl:ENSG00000166170 euGenes: HUgn9529
ECgene: BAG5 H-InvDB: BAG5
(According to HUGE)
About This Section

HUGE: KIAA0873
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for BAG5:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for BAG5 Antibodies for BAG5
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant Proteins
(Bag5)
 Antibodies (Bag5)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for BAG5




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for BAG5

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