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Aliases for BAG5 Gene

Aliases for BAG5 Gene

  • BCL2 Associated Athanogene 5 2 3 5
  • Bcl-2-Associated Athanogene 5 3 4
  • BAG-5 3 4
  • BAG Family Molecular Chaperone Regulator 5 3
  • KIAA0873 4

External Ids for BAG5 Gene

Previous GeneCards Identifiers for BAG5 Gene

  • GC14M101414
  • GC14M097838
  • GC14M102013
  • GC14M103093
  • GC14M104022
  • GC14M084201

Summaries for BAG5 Gene

Entrez Gene Summary for BAG5 Gene

  • The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAG5 Gene

BAG5 (BCL2 Associated Athanogene 5) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence. GO annotations related to this gene include protein kinase binding and chaperone binding. An important paralog of this gene is BAG3.

UniProtKB/Swiss-Prot for BAG5 Gene

  • Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.

Gene Wiki entry for BAG5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG5 Gene

Genomics for BAG5 Gene

Regulatory Elements for BAG5 Gene

Enhancers for BAG5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G103204 2 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +355.5 355479 6.0 PKNOX1 ARNT ZNF133 GLI4 BRCA1 TCF12 CBX5 GATA2 ZNF416 GTF2B XRCC3 CDC42BPB BAG5 RCOR1 LINC00605 TNFAIP2 ENSG00000269940 EXOC3L4 ENSG00000270705 GC14M103156
GH14G103517 1.6 Ensembl ENCODE dbSUPER 11.4 +42.2 42163 6.4 HDGF ARNT AGO1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B SLC30A9 CBX5 MARK3 CKB CDC42BPB RNU7-160P BAG5 ENSG00000269940 XRCC3 APOPT1 GC14M103376 GC14P103445
GH14G103054 1.4 ENCODE dbSUPER 11.1 +506.1 506060 3.9 HDGF FOXA2 ARNT AGO1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZBTB7B XRCC3 RCOR1 CDC42BPB BAG5 RPL13P6
GH14G103627 1.4 ENCODE dbSUPER 10.6 -66.3 -66305 3.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF143 KLC1 XRCC3 ZFYVE21 BAG5 APOPT1 LOC105370688 RNU4-68P
GH14G102588 1.2 ENCODE 10.7 +970.9 970865 6.8 ZFP64 FEZF1 DMAP1 ZNF143 ZNF548 SP3 NFYC TBX21 ZFP41 ZNF610 CDC42BPB DYNC1H1 BAG5 ENSG00000272444 RCOR1 CKB ENSG00000259775 LINC02323 GC14P102906
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BAG5 on UCSC Golden Path with GeneCards custom track

Promoters for BAG5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000073580 131 2601 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF207 ZNF143 FOS

Genomic Location for BAG5 Gene

Chromosome:
14
Start:
103,556,544 bp from pter
End:
103,562,831 bp from pter
Size:
6,288 bases
Orientation:
Minus strand

Genomic View for BAG5 Gene

Genes around BAG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG5 Gene

Proteins for BAG5 Gene

  • Protein details for BAG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL15-BAG5_HUMAN
    Recommended name:
    BAG family molecular chaperone regulator 5
    Protein Accession:
    Q9UL15
    Secondary Accessions:
    • O94950
    • Q86W59

    Protein attributes for BAG5 Gene

    Size:
    447 amino acids
    Molecular mass:
    51200 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PARK2.
    SequenceCaution:
    • Sequence=BAA74896.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BAG5 Gene

    Alternative splice isoforms for BAG5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAG5 Gene

Post-translational modifications for BAG5 Gene

  • Ubiquitination at Lys48
  • Modification sites at PhosphoSitePlus

Other Protein References for BAG5 Gene

No data available for DME Specific Peptides for BAG5 Gene

Domains & Families for BAG5 Gene

Gene Families for BAG5 Gene

Protein Domains for BAG5 Gene

Suggested Antigen Peptide Sequences for BAG5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UL15

UniProtKB/Swiss-Prot:

BAG5_HUMAN :
  • The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.
Domain:
  • The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.
genes like me logo Genes that share domains with BAG5: view

Function for BAG5 Gene

Molecular function for BAG5 Gene

GENATLAS Biochemistry:
BCL2-associated athanogene 5 (antiapoptotic). Negative regulator of Hsp70 chaperone activity
UniProtKB/Swiss-Prot Function:
Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.

Gene Ontology (GO) - Molecular Function for BAG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IPI 24510904
GO:0019901 protein kinase binding IPI 24475098
GO:0031625 ubiquitin protein ligase binding ISS,IPI 15603737
GO:0051087 chaperone binding IPI 15603737
genes like me logo Genes that share ontologies with BAG5: view
genes like me logo Genes that share phenotypes with BAG5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BAG5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BAG5 Gene

Localization for BAG5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BAG5 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4

Gene Ontology (GO) - Cellular Components for BAG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA 24475098
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0016234 inclusion body IDA 15603737
genes like me logo Genes that share ontologies with BAG5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BAG5 Gene

Pathways & Interactions for BAG5 Gene

genes like me logo Genes that share pathways with BAG5: view

Gene Ontology (GO) - Biological Process for BAG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9873016
GO:0007030 Golgi organization IMP 24510904
GO:0010977 negative regulation of neuron projection development IDA 24510904
GO:0031397 negative regulation of protein ubiquitination IMP,ISS 15603737
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA 24475098
genes like me logo Genes that share ontologies with BAG5: view

No data available for SIGNOR curated interactions for BAG5 Gene

Drugs & Compounds for BAG5 Gene

No Compound Related Data Available

Transcripts for BAG5 Gene

Unigene Clusters for BAG5 Gene

BCL2-associated athanogene 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BAG5

Alternative Splicing Database (ASD) splice patterns (SP) for BAG5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - - -
SP2: -
SP3:

Relevant External Links for BAG5 Gene

GeneLoc Exon Structure for
BAG5
ECgene alternative splicing isoforms for
BAG5

Expression for BAG5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BAG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BAG5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BAG5 Gene



Protein tissue co-expression partners for BAG5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BAG5 Gene:

BAG5

SOURCE GeneReport for Unigene cluster for BAG5 Gene:

Hs.5443

Evidence on tissue expression from TISSUES for BAG5 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with BAG5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAG5 Gene

Orthologs for BAG5 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAG5 34 35
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia BAG5 34 35
  • 90.08 (n)
cow
(Bos Taurus)
Mammalia BAG5 34 35
  • 87.47 (n)
rat
(Rattus norvegicus)
Mammalia Bag5 34
  • 84.94 (n)
mouse
(Mus musculus)
Mammalia Bag5 34 16 35
  • 83.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BAG5 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BAG5 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves BAG5 34 35
  • 73.75 (n)
lizard
(Anolis carolinensis)
Reptilia BAG5 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bag5 34
  • 64.94 (n)
Str.13078 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.33765 34
zebrafish
(Danio rerio)
Actinopterygii bag5 34 35
  • 56.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta stv 35
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5020 35
  • 17 (a)
OneToMany
Species where no ortholog for BAG5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAG5 Gene

ENSEMBL:
Gene Tree for BAG5 (if available)
TreeFam:
Gene Tree for BAG5 (if available)

Paralogs for BAG5 Gene

Paralogs for BAG5 Gene

genes like me logo Genes that share paralogs with BAG5: view

Variants for BAG5 Gene

Sequence variations from dbSNP and Humsavar for BAG5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000625251 -- 103,562,825(+) AAGGA(G/T)CGGCC upstream-variant-2KB
rs1001001538 -- 103,556,563(+) AAGCG(-/T)TAAGA utr-variant-3-prime
rs1001089946 -- 103,557,196(+) TTACA(A/G)ATCAC utr-variant-3-prime
rs1001117076 -- 103,556,862(+) CCAGA(C/T)AGAAA utr-variant-3-prime
rs1001521297 -- 103,561,500(+) CCAGC(A/G)GGGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BAG5 Gene

Variant ID Type Subtype PubMed ID
dgv389n67 CNV gain 20364138
esv3635599 CNV gain 21293372
nsv1054574 CNV loss 25217958
nsv566022 CNV loss 21841781
nsv832883 CNV loss 17160897

Variation tolerance for BAG5 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BAG5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BAG5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG5 Gene

Disorders for BAG5 Gene

Relevant External Links for BAG5

Genetic Association Database (GAD)
BAG5
Human Genome Epidemiology (HuGE) Navigator
BAG5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BAG5

No disorders were found for BAG5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BAG5 Gene

Publications for BAG5 Gene

  1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S. … Reed J.C. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 46 64
  5. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly J.L. … Cerhan J.R. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64

Products for BAG5 Gene

  • Addgene plasmids for BAG5

Sources for BAG5 Gene

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