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Aliases & Descriptions for BAG5
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases BAG-5 2 , 3 KIAA0873 3
Descriptions BAG-family molecular chaperone regulator-5 2 BCL2-associated athanogene 5 2 Bcl-2-associated athanogene 5 3
Search outside databases for aliases for BAG5 genePrevious GC identifers: GC14M101414 GC14M097838 GC14M102013
Summaries for BAG5 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for BAG5 : The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is ananti-apoptotic protein that functions through interactions with a variety of cell apoptosis andgrowth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growthfactor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAGdomain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70.Three transcript variants encoding two different isoforms have been found for this gene. [providedby RefSeq] UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15 Function : Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibitsboth auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity)
Gene Wiki entry for BAG5
Genomic Location for BAG5
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the BAG5 gene Entrez Gene cytogenetic band: 14q32.33 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32 BAG5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M103093:
(about GC identifiers )
Start:
103,092,642 bp from pter
End:
103,098,904 bp from pter
Size:
6,263 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000014.7 NT_026437.11 Proteins for BAG5
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
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Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15 (See
protein sequence )Recommended Name: BAG family molecular chaperone regulator 5 Size : 447 amino acids; 51200 Da
Subunit : Binds to the ATPase domain of HSP70/HSC chaperones. Binds PARK2 (By similarity)
PDB structures from and Proteopedia : 2D9D (3D)
 
Secondary accessions : O94950 Q86W59
REFSEQ proteins (3 alternative transcripts):
NP_001015048.1 NP_001015049.1 NP_004864.1 ENSEMBL proteins: ENSP00000338814 ENSP00000299204 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: BAG5 Antibodies for BAG5: Assays for BAG5:
Protein
Domains/ Families for BAG5(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UL15 ProtoNet protein and cluster: Q9UL15
1 Blocks protein family : IPB003103 Apoptosis regulator Bcl-2 protein UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15 Similarity : Contains 4 BAG domains
Gene Function for BAG5
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001015048 Applied Biosystems Silencer ® siRNAs for BAG5 Sigma-Aldrich siRNA for BAG5 Sigma-Aldrich shRNA Panels and shRNA for BAG5 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001015048                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001015048                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001015048  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001015049 UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15 Function : Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibitsboth auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity)
Genatlas biochemistry entry for BAG5 :BCL2-associated athanogene 5 (antiapoptotic). Negative regulator of Hsp70 chaperone activity 1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
IEA --
About this table
Pathways & Interactions for BAG5
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for BAG5 5/18 Interacting proteins for BAG5 (ENSP00000338814 3 Q9UL15 2 ) via UniProtKB, MINT, and/or STRING (see all 18
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for BAG5 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for BAG5
Transcripts for BAG5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001015048 Sigma-Aldrich siRNA for BAG5 Sigma-Aldrich shRNA Panels and shRNA for BAG5 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001015048 NM_001015049 NM_004873
REFSEQ mRNAs for BAG5 gene (3 alternative transcripts): NM_001015048.1 NM_001015049.1 NM_004873.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001015048 NM_001015049 NM_004873
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001015048                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001015048                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001015048  
Additional cDNA sequence: AB020680.1 AF095195.2 AK001378.1 AK023145.1 AK225730.1 AK225741.1 AK291312.1 BC044216.1 BC050551.1
11 DOTS entries : DT.99986185 DT.95081860 DT.452049 DT.120790950 DT.120790749 DT.40189856 DT.100792714 DT.120790876 DT.100792711 DT.100792712 DT.120790743
24/208 AceView cDNA sequences (see all 208
):AI457485 AW069057 BM452522 AL701774 AI200808 CA420231 AB020680 AA427991 AA456862 AW591824 AI368884 AA457021 W15295 AI701102 CN482320 AW129332 AI272932 AW673909 BQ223297 BX956841 BG413412 AA604411 BC050551 AL709127
highest scoring ESTs for BAG5 :AB020680 AI929707 AL701774 AL709127 AL711196 AU279920 AW129332 AW295053 BE041589 BF941752
Unigene Cluster for BAG5: BCL2-associated athanogene 5 Hs.5443 [show with all ESTs ] Unigene Representative Sequence: NM_001015049 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for BAG5 ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c SP1 :   -   -   -         SP2 :       -         SP3 :              
About this scheme ECgene alternative splicing isoforms for BAG5 2 Ensembl transcripts including schematic representations : ENST00000337322
ENST00000299204
Expression for BAG5
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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BAG5 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for BAG5 1 / 2 / 3
8 probe-sets matching BAG5 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TGTTAATATASOURCE GeneReport for Unigene cluster: Hs.5443 Expression variation in blood from EXPOLDB for BAG5
Orthologs for BAG5
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for BAG5 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for BAG5 ENSEMBL Gene Tree for BAG5 Paralogs for BAG5 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for BAG5 gene BAG4 2 BAG3 2
SNPs/Variants for BAG5 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for BAG5 (up to first 250kb)
Disorders & Mutations for BAG5
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
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and/or TGDB .)
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OMIM: 603885
Medical News for BAG5 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for BAG5 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/11 PubMed articles for BAG5 gene (see all 11
): An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PubMed id 9873016) 1, 2, 3, 4 Takayama S.... Reed J.C. (1999) BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. (PubMed id 15603737) 2, 3 Kalia S.K....Lozano A.M. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485) 3, 4 Nagase T....Ohara O. (1998) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3 Ota T....Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. (PubMed id 9321400) 3 Hohfeld J. and Jentsch S. (1997) Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149) 3 Suzuki Y.... Sugano S. (1997) Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. (PubMed id 7834747) 3 Takayama S....Reed J.C. (1995) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298) 3 Maruyama K. and Sugano S. (1994)
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Genome Databases showing BAG5
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
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Other Databases showing BAG5
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Specialized Databases showing BAG5 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for BAG5 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for BAG5:
Recombinant Proteins (Bag5 ) Antibodies (Bag5 )
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