Aliases for BAG5 Gene
Aliases for BAG5 Gene
External Ids for BAG5 Gene
- HGNC: 941
- Entrez Gene: 9529
- Ensembl: ENSG00000166170
- OMIM: 603885
- UniProtKB: Q9UL15
Previous GeneCards Identifiers for BAG5 Gene
- GC14M101414
- GC14M097838
- GC14M102013
- GC14M103093
- GC14M104022
- GC14M084201
Summaries for BAG5 Gene
-
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for BAG5 Gene
BAG5 (BCL2 Associated Athanogene 5) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence. GO annotations related to this gene include protein kinase binding and chaperone binding. An important paralog of this gene is BAG3.
UniProtKB/Swiss-Prot for BAG5 Gene
-
Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG5 Gene
Genomics for BAG5 Gene
Regulatory Elements for BAG5 Gene
- Transcription factor binding sites by QIAGEN in the BAG5 gene promoter:
Regulatory Element Products
Genomic Location for BAG5 Gene
- Chromosome:
- 14
- Start:
- 103,556,544 bp from pter
- End:
- 103,562,831 bp from pter
- Size:
- 6,288 bases
- Orientation:
- Minus strand
Genomic View for BAG5 Gene
- Cytogenetic band:
-
- 14q32.33 by Ensembl
- 14q32.33 by Entrez Gene
- 14q32.33 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BAG5 Gene
Proteins for BAG5 Gene
-
Protein details for BAG5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UL15-BAG5_HUMAN
- Recommended name:
- BAG family molecular chaperone regulator 5
- Protein Accession:
- Q9UL15
- O94950
- Q86W59
Protein attributes for BAG5 Gene
- Size:
- 447 amino acids
- Molecular mass:
- 51200 Da
- Quaternary structure:
-
- Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PARK2.
- SequenceCaution:
-
- Sequence=BAA74896.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for BAG5 Gene
Post-translational modifications for BAG5 Gene
Other Protein References for BAG5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for BAG5
- Invitrogen Antibodies for BAG5
- antibodies-online Antibodies for BAG5: See all 138
- GeneTex BAG5 antibody for BAG5
-
Santa Cruz Biotechnology (SCBT) Antibodies for BAG5
Protein Products
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OriGene Purified Proteins for BAG5
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-
Cloud-Clone Corp. Proteins for BAG5
- antibodies-online Proteins for BAG5: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for BAG5
Assay Products
- antibodies-online Kits for BAG5: See all 3
No data available for DME Specific Peptides for BAG5 Gene
Domains & Families for BAG5 Gene
Gene Families for BAG5 Gene
Protein Domains for BAG5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for BAG5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UL15UniProtKB/Swiss-Prot:
BAG5_HUMAN :- The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.
- Domain:
-
- The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.
Function for BAG5 Gene
Molecular function for BAG5 Gene
- GENATLAS Biochemistry:
- BCL2-associated athanogene 5 (antiapoptotic). Negative regulator of Hsp70 chaperone activity
- UniProtKB/Swiss-Prot Function:
- Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000774 | adenyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 24510904 |
| GO:0019901 | protein kinase binding | IPI | 24475098 |
| GO:0031625 | ubiquitin protein ligase binding | ISS,IPI | 15603737 |
| GO:0051087 | chaperone binding | IPI | 15603737 |
Phenotypes for BAG5 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for BAG5 gene
-
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CRISPR Products
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miRNA for BAG5 Gene
- miRTarBase miRNAs that target BAG5
-
- hsa-mir-155-5p (MIRT020553)
- hsa-mir-124-3p (MIRT022122)
- hsa-mir-1-3p (MIRT023533)
- hsa-let-7b-5p (MIRT032220)
- hsa-mir-615-3p (MIRT040079)
- hsa-mir-484 (MIRT041624)
- hsa-mir-5572 (MIRT524781)
- hsa-mir-4260 (MIRT524782)
- hsa-mir-450a-2-3p (MIRT524783)
- hsa-mir-6803-5p (MIRT524784)
- hsa-mir-6751-5p (MIRT524785)
- hsa-mir-7109-5p (MIRT524786)
- hsa-mir-4665-5p (MIRT524787)
- hsa-mir-1275 (MIRT524788)
- hsa-mir-6885-5p (MIRT524789)
- hsa-mir-328-5p (MIRT524790)
- hsa-mir-6887-5p (MIRT524791)
- hsa-mir-6795-5p (MIRT524792)
- hsa-mir-128-2-5p (MIRT524793)
- hsa-mir-128-1-5p (MIRT524794)
- hsa-mir-6877-5p (MIRT524795)
- hsa-mir-4767 (MIRT524796)
- hsa-mir-6087 (MIRT524797)
- hsa-mir-383-3p (MIRT524798)
miRNA Products
- Search ViGene Biosciences for BAG5
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for BAG5
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for BAG5
-
ViGene Biosciences adenoviral particle packaged cDNA for BAG5 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BAG5 Gene
Localization for BAG5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 21630459 |
| GO:0005739 | mitochondrion | IDA | 24475098 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IDA | 19946888 |
| GO:0016234 | inclusion body | IDA | 15603737 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for BAG5 Gene
Pathways & Interactions for BAG5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular response to heat stress | ||
| 2 | Cellular Senescence | ||
Pathways by source for BAG5 Gene
3 Reactome pathways for BAG5 Gene
Interacting Proteins for BAG5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006457 | protein folding | TAS | 9873016 |
| GO:0007030 | Golgi organization | IMP | 24510904 |
| GO:0010977 | negative regulation of neuron projection development | IDA | 24510904 |
| GO:0031397 | negative regulation of protein ubiquitination | IMP,ISS | 15603737 |
| GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | IDA | 24475098 |
No data available for SIGNOR curated interactions for BAG5 Gene
Transcripts for BAG5 Gene
mRNA/cDNA for BAG5 Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (208) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for BAG5 Gene
- BCL2-associated athanogene 5:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for BAG5
-
Santa Cruz Biotechnology (SCBT) CRISPR for BAG5
- GenScript: Design CRISPR guide RNA sequences for BAG5
miRNA Products
- Search ViGene Biosciences for BAG5
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for BAG5
- Browse OriGene Inhibitory RNA Products For BAG5
-
ViGene Biosciences ready-to-package AAV shRNAs for BAG5 gene
Clone Products
- Sino Biological Human cDNA Clone for BAG5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for BAG5
- VectorBuilder custom plasmid, inducible vectors for BAG5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAG5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||
| SP2: | - | ||||||||||||
| SP3: |
Expression for BAG5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BAG5 Gene
NURSA nuclear receptor signaling pathways regulating expression of BAG5 Gene:
BAG5SOURCE GeneReport for Unigene cluster for BAG5 Gene:
Hs.5443Evidence on tissue expression from TISSUES for BAG5 Gene
- Nervous system(4.8)
Primer Products
-
OriGene qPCR primer pairs for BAG5
-
OriGene qPCR primer pairs and template standards for BAG5
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAG5 Gene
Orthologs for BAG5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BAG5 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | BAG5 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | BAG5 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bag5 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Bag5 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | BAG5 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | BAG5 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BAG5 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | BAG5 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bag5 34 |
|
||
| Str.13078 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.33765 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | bag5 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | stv 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5020 35 |
|
OneToMany |
- Species where no ortholog for BAG5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for BAG5 Gene
Variants for BAG5 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000625251 | -- | 103,562,825(+) | AAGGA(G/T)CGGCC | upstream-variant-2KB | |
| rs1001001538 | -- | 103,556,563(+) | AAGCG(-/T)TAAGA | utr-variant-3-prime | |
| rs1001089946 | -- | 103,557,196(+) | TTACA(A/G)ATCAC | utr-variant-3-prime | |
| rs1001117076 | -- | 103,556,862(+) | CCAGA(C/T)AGAAA | utr-variant-3-prime | |
| rs1001521297 | -- | 103,561,500(+) | CCAGC(A/G)GGGCA | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv389n67 | CNV | gain | 20364138 |
| esv3635599 | CNV | gain | 21293372 |
| nsv1054574 | CNV | loss | 25217958 |
| nsv566022 | CNV | loss | 21841781 |
| nsv832883 | CNV | loss | 17160897 |
Relevant External Links for BAG5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BAG5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG5 Gene
Disorders for BAG5 Gene
Relevant External Links for BAG5
No disorders were found for BAG5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BAG5 Gene
Publications for BAG5 Gene
- An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S. … Reed J.C. (J. Biol. Chem. 1999) 2 3 4 22 64
- High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3 4 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 46 64
- Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly J.L. … Cerhan J.R. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
Products for BAG5 Gene
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- antibodies-online Proteins for BAG5: See all 9
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- GeneTex BAG5 antibody for BAG5
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- ViGene Biosciences adenoviral particle packaged cDNA for BAG5 gene
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- Search ViGene Biosciences for BAG5
- Santa Cruz Biotechnology (SCBT) Antibodies for BAG5
- Search Santa Cruz Biotechnology (SCBT) for BAG5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BAG5
- Horizon Cell Lines for BAG5
- Cyagen custom Knockout/knockin (KOKI) mouse models for BAG5
- VectorBuilder custom plasmid, inducible vectors for BAG5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAG5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for BAG5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




