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Aliases for BAG5 Gene

Aliases for BAG5 Gene

  • BCL2 Associated Athanogene 5 2 3 5
  • Bcl-2-Associated Athanogene 5 3 4
  • BAG-5 3 4
  • BAG-Family Molecular Chaperone Regulator-5 3
  • BCL2-Associated Athanogene 5 3
  • KIAA0873 4

External Ids for BAG5 Gene

Previous GeneCards Identifiers for BAG5 Gene

  • GC14M101414
  • GC14M097838
  • GC14M102013
  • GC14M103093
  • GC14M104022
  • GC14M084201

Summaries for BAG5 Gene

Entrez Gene Summary for BAG5 Gene

  • The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAG5 Gene

BAG5 (BCL2 Associated Athanogene 5) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence. GO annotations related to this gene include protein kinase binding and chaperone binding. An important paralog of this gene is BAG4.

UniProtKB/Swiss-Prot for BAG5 Gene

  • Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.

Gene Wiki entry for BAG5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG5 Gene

Genomics for BAG5 Gene

Regulatory Elements for BAG5 Gene

Promoters for BAG5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BAG5 on UCSC Golden Path with GeneCards custom track

Genomic Location for BAG5 Gene

Chromosome:
14
Start:
103,556,544 bp from pter
End:
103,562,831 bp from pter
Size:
6,288 bases
Orientation:
Minus strand

Genomic View for BAG5 Gene

Genes around BAG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG5 Gene

Proteins for BAG5 Gene

  • Protein details for BAG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL15-BAG5_HUMAN
    Recommended name:
    BAG family molecular chaperone regulator 5
    Protein Accession:
    Q9UL15
    Secondary Accessions:
    • O94950
    • Q86W59

    Protein attributes for BAG5 Gene

    Size:
    447 amino acids
    Molecular mass:
    51200 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PARK2.
    SequenceCaution:
    • Sequence=BAA74896.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BAG5 Gene

    Alternative splice isoforms for BAG5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAG5 Gene

Proteomics data for BAG5 Gene at MOPED

Post-translational modifications for BAG5 Gene

  • Ubiquitination at Lys 48
  • Modification sites at PhosphoSitePlus

Other Protein References for BAG5 Gene

Antibody Products

No data available for DME Specific Peptides for BAG5 Gene

Domains & Families for BAG5 Gene

Gene Families for BAG5 Gene

Protein Domains for BAG5 Gene

Suggested Antigen Peptide Sequences for BAG5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UL15

UniProtKB/Swiss-Prot:

BAG5_HUMAN :
  • The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.
Domain:
  • The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.
  • Contains 5 BAG domains.
genes like me logo Genes that share domains with BAG5: view

Function for BAG5 Gene

Molecular function for BAG5 Gene

GENATLAS Biochemistry:
BCL2-associated athanogene 5 (antiapoptotic). Negative regulator of Hsp70 chaperone activity
UniProtKB/Swiss-Prot Function:
Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.

Gene Ontology (GO) - Molecular Function for BAG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity TAS --
GO:0031625 ubiquitin protein ligase binding ISS 15603737
genes like me logo Genes that share ontologies with BAG5: view
genes like me logo Genes that share phenotypes with BAG5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BAG5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BAG5 Gene

Localization for BAG5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAG5 Gene COMPARTMENTS Subcellular localization image for BAG5 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 4

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BAG5 Gene

Pathways & Interactions for BAG5 Gene

genes like me logo Genes that share pathways with BAG5: view

Gene Ontology (GO) - Biological Process for BAG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9873016
GO:0007030 Golgi organization IMP 24510904
GO:0031397 negative regulation of protein ubiquitination ISS 15603737
GO:0034605 cellular response to heat TAS --
GO:0051438 regulation of ubiquitin-protein transferase activity TAS 24270810
genes like me logo Genes that share ontologies with BAG5: view

No data available for SIGNOR curated interactions for BAG5 Gene

Drugs & Compounds for BAG5 Gene

No Compound Related Data Available

Transcripts for BAG5 Gene

Unigene Clusters for BAG5 Gene

BCL2-associated athanogene 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BAG5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - - -
SP2: -
SP3:

Relevant External Links for BAG5 Gene

GeneLoc Exon Structure for
BAG5
ECgene alternative splicing isoforms for
BAG5

Expression for BAG5 Gene

mRNA expression in normal human tissues for BAG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BAG5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAG5 Gene



SOURCE GeneReport for Unigene cluster for BAG5 Gene Hs.5443

genes like me logo Genes that share expression patterns with BAG5: view

Protein tissue co-expression partners for BAG5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BAG5 Gene

Orthologs for BAG5 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BAG5 35
  • 87.47 (n)
  • 93.74 (a)
BAG5 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAG5 35
  • 90.08 (n)
  • 96.42 (a)
BAG5 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bag5 35
  • 83.82 (n)
  • 91.28 (a)
Bag5 16
Bag5 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BAG5 35
  • 99.33 (n)
  • 99.55 (a)
BAG5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bag5 35
  • 84.94 (n)
  • 90.83 (a)
oppossum
(Monodelphis domestica)
Mammalia BAG5 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAG5 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves BAG5 35
  • 73.75 (n)
  • 79.87 (a)
BAG5 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BAG5 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bag5 35
  • 64.94 (n)
  • 66.74 (a)
Str.13078 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33765 35
zebrafish
(Danio rerio)
Actinopterygii bag5 35
  • 56.9 (n)
  • 54 (a)
bag5 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta stv 36
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5020 36
  • 17 (a)
OneToMany
Species with no ortholog for BAG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAG5 Gene

ENSEMBL:
Gene Tree for BAG5 (if available)
TreeFam:
Gene Tree for BAG5 (if available)

Paralogs for BAG5 Gene

Paralogs for BAG5 Gene

genes like me logo Genes that share paralogs with BAG5: view

Variants for BAG5 Gene

Sequence variations from dbSNP and Humsavar for BAG5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs17854644 - 103,560,694(+) ACCGC(A/C)CAGAT reference, missense
rs7693 -- 103,557,367(+) GAAAC(C/T)AGAAA utr-variant-3-prime
rs14906 -- 103,556,754(-) TTTCT(C/G/T)TTAAT utr-variant-3-prime
rs7154948 -- 103,556,607(+) ATTAA(C/T)ACATG utr-variant-3-prime
rs7154587 -- 103,556,413(+) gatcg(C/T)gctat downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for BAG5 Gene

Variant ID Type Subtype PubMed ID
nsv832883 CNV Loss 17160897
dgv1992n71 CNV Loss 21882294
nsv902300 CNV Loss 21882294
dgv1994n71 CNV Loss 21882294
dgv389n67 CNV Gain 20364138

Variation tolerance for BAG5 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BAG5 Gene

HapMap Linkage Disequilibrium report
BAG5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG5 Gene

Disorders for BAG5 Gene

Relevant External Links for BAG5

Genetic Association Database (GAD)
BAG5
Human Genome Epidemiology (HuGE) Navigator
BAG5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BAG5

No disorders were found for BAG5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BAG5 Gene

Publications for BAG5 Gene

  1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S. … Reed J.C. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. (PMID: 15603737) Kalia S.K. … Lozano A.M. (Neuron 2004) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. (PMID: 24475098) Wang X. … Tang B. (PLoS ONE 2014) 3
  5. Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. (PMID: 24510904) Beilina A. … Cookson M.R. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for BAG5 Gene

Sources for BAG5 Gene

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