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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BAG5 Gene

protein-coding   GIFtS: 56
GCID: GC14M104022

BCL2-Associated Athanogene 5

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BCL2-Associated Athanogene 51 2
Bcl-2-Associated Athanogene 52 3
BAG-52 3
BAG Family Molecular Chaperone Regulator 52
BAG-Family Molecular Chaperone Regulator-52
KIAA08733

External Ids:    HGNC: 9411   Entrez Gene: 95292   Ensembl: ENSG000001661707   OMIM: 6038855   UniProtKB: Q9UL153   

Export aliases for BAG5 gene to outside databases

Previous GC identifers: GC14M101414 GC14M097838 GC14M102013 GC14M103093 GC14M084201


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BAG5 Gene:
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein
that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2,
Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70
kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone
activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for BAG5 Gene: 
BAG5 (BCL2-associated athanogene 5) is a protein-coding gene. Diseases associated with BAG5 include toxoplasmosis, and non-hodgkin lymphoma. GO annotations related to this gene include chaperone binding and ubiquitin protein ligase binding. An important paralog of this gene is BAG4.

UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15
Function: Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By
similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating
Hsp70-mediated refolding

Gene Wiki entry for BAG5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BAG5 gene promoter:
         PPAR-alpha   AREB6   Nkx2-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BAG5 promoter sequence
   Search SABiosciences Chromatin IP Primers for BAG5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAG5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32

BAG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAG5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M104022:  view genomic region     (about GC identifiers)

Start:
104,022,881 bp from pter      End:
104,029,168 bp from pter
Size:
6,288 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15 (See protein sequence)
Recommended Name: BAG family molecular chaperone regulator 5  
Size: 447 amino acids; 51200 Da
Subunit: Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PARK2 (By similarity)
Sequence caution: Sequence=BAA74896.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for BAG5:
2D9D (3D)        3A8Y (3D)    
Secondary accessions: O94950 Q86W59
Alternative splicing: 2 isoforms:  Q9UL15-1   Q9UL15-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BAG5: NX_Q9UL15

Explore proteomics data for BAG5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UL15

  • BAG5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BAG5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001015048.1  NP_001015049.1  NP_004864.1  

    ENSEMBL proteins: 
     ENSP00000391713   ENSP00000338814   ENSP00000450497   ENSP00000299204  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016234inclusion body IDA15603737
    GO:0048471perinuclear region of cytoplasm IDA15603737

    BAG5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003103 BAG_domain

    Graphical View of Domain Structure for InterPro Entry Q9UL15

    ProtoNet protein and cluster: Q9UL15

    1 Blocks protein domain: IPB003103 Apoptosis regulator Bcl-2 protein

    UniProtKB/Swiss-Prot: BAG5_HUMAN, Q9UL15
    Domain: The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain
    Similarity: Contains 5 BAG domains


    BAG5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BAG5_HUMAN, Q9UL15
    Function: Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By
    similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating
    Hsp70-mediated refolding

         Genatlas biochemistry entry for BAG5:
    BCL2-associated athanogene 5 (antiapoptotic). Negative regulator of Hsp70 chaperone activity

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031625ubiquitin protein ligase binding ISS15603737
    GO:0051087chaperone binding IPI15603737
         
    BAG5 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BAG5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/24 Interacting proteins for BAG5 (Q9UL152, 3 ENSP000003388144) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K1Q132332, 3MINT-48282 I2D: score=2 
    MAP3K3Q997592, 3MINT-48391 I2D: score=2 
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS9873016
    GO:0031397negative regulation of protein ubiquitination ISS15603737
    GO:0051444negative regulation of ubiquitin-protein ligase activity ISS15603737
    GO:0061084negative regulation of protein refolding ISS15603737
    GO:0070997neuron death ISS15603737

    BAG5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BAG5

    Search CenterWatch for drugs/clinical trials and news about BAG5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BAG5 gene (3 alternative transcripts): 
    NM_001015048.2  NM_001015049.2  NM_004873.3  

    Unigene Cluster for BAG5:

    BCL2-associated athanogene 5
    Hs.5443  [show with all ESTs]
    Unigene Representative Sequence: NM_001015049
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445922(uc001yni.2 uc001ynh.2) ENST00000337322 ENST00000557666
    ENST00000299204(uc001ynj.2)

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    Additional mRNA sequence: 

    AB020680.1 AF095195.2 AK001378.1 AK023145.1 AK225730.1 AK225741.1 AK291312.1 BC044216.1 
    BC050551.1 

    11 DOTS entries:

    DT.99986185  DT.95081860  DT.452049  DT.120790950  DT.120790749  DT.40189856  DT.100792714  DT.120790876 
    DT.100792711  DT.100792712  DT.120790743 

    24/208 AceView cDNA sequences (see all 208):

    CA424706 AA456862 BQ223297 AL709127 CA420231 BG413412 AW129332 AW069057 
    AA425634 BM793091 AI701102 CN482320 BM452522 AA442360 AW673909 NM_004873 
    W15295 BM553169 BC050551 AI457485 AI368884 AA604411 AW675074 BP369135 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for BAG5    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
    SP1:        -     -     -                     
    SP2:                    -                     
    SP3:                                          


    ECgene alternative splicing isoforms for BAG5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BAG5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTAATATA
    BAG5 Expression
    About this image


    See BAG5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BAG5

    SOURCE GeneReport for Unigene cluster: Hs.5443
        SABiosciences Expression via Pathway-Focused PCR Array including BAG5: 
              Heat Shock Proteins & Chaperones in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BAG5 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bag51 , 5 BCL2-associated athanogene 51, 5 83.82(n)1
    91.28(a)1
      12 (61.11 cM)5
    703691  NM_027404.21  NP_081680.11 
     1117094885 
    chicken
    (Gallus gallus)
    Aves BAG51 BCL2-associated athanogene 5 73.75(n)
    79.87(a)
      423482  NM_001031211.1  NP_001026382.1 
    lizard
    (Anolis carolinensis)
    Reptilia BAG56
    Uncharacterized protein
    77(a)
    1 ↔ 1
    1(6142212-6143564)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.337652 Xenopus laevis transcribed sequence with weak similarity more 73.66(n)    BJ097504.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bag51 BCL2-associated athanogene 5 56.96(n)
    53.67(a)
      569580  NM_001034183.1  NP_001029355.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta stv6
    starvin
    6(a)
    1 → many
    3L(13470641-13476615)


    ENSEMBL Gene Tree for BAG5 (if available)
    TreeFam Gene Tree for BAG5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BAG5 gene
    BAG42  BAG32  

    BAG5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/111 SNPs in BAG5 are shown (see all 111)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1897729621,2
    --104022619(+) GAAACC/GCTGTC 3 -- ds50010--------
    rs1419187421,2
    C--104022660(+) GTTGTA/GGCAGG 3 -- ds50010--------
    rs1928165401,2
    C--104022665(+) GGCAGG/TCACCT 3 -- ds50010--------
    rs71545871,2
    C,F,A,H--104022750(+) gatcgT/Cgctat 3 -- ds50014Minor allele frequency- C:0.30NA WA CSA 10
    rs1484690771,2
    --104022771(+) CCTGGA/GTGACA 3 -- ds50010--------
    rs113768391,2
    C--104022793(+) AAAAA-/A/AA  
            
    AAAAA
    3 -- ds50011NA 2
    rs760052681,2
    C,F--104022899(+) GCAAGC/TGTAAG 3 -- ut311Minor allele frequency- T:0.05WA 118
    rs1851986441,2
    --104022900(+) CAAGCA/GTAAGA 3 -- ut310--------
    rs71549481,2
    C,F,A,H--104022944(+) ATTAAC/TACATG 3 -- ut3123Minor allele frequency- T:0.24NS EA NA WA CSA 2354
    rs1900949801,2
    --104023017(+) GAGGGA/GACAGG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for BAG5 (104022881 - 104029168 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for BAG5:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1992n71CNV Loss21882294
    nsv832883CNV Loss17160897
    nsv902300CNV Loss21882294
    dgv1994n71CNV Loss21882294
    dgv389n67CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603885    OMIM disorders: --

    5 diseases for BAG5:    About MalaCards
    toxoplasmosis    non-hodgkin lymphoma    hodgkin's lymphoma    parkinson's disease
    neuronitis


    BAG5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): BAG5
    Human Genome Epidemiology (HuGE) Navigator: BAG5 (5 documents)

    Export disorders for BAG5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BAG5 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with BAG5)
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    1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PubMed id 9873016)1, 2, 3, 9 Takayama S.... Reed J.C. (1999)
    2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    3. Germline variation in apoptosis pathway genes and ris k of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. (PubMed id 15603737)1, 3 Kalia S.K....Lozano A.M. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis. (PubMed id 23448667)1 Bruchmann A....Maddalo D. (2013)
    10. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9529 HGNC: 941 AceView: BAG5 Ensembl:ENSG00000166170 euGenes: HUgn9529
    ECgene: BAG5 H-InvDB: BAG5

    (According to HUGE)
    About This Section
    HUGE: KIAA0873

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BAG5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BAG5 gene:
    Search GeneIP for patents involving BAG5

    GeneCards and IP:
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