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Aliases & Descriptions for BAG4
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BAG-4 2, 3 | | SODD 1, 2, 3 |
| | | Descriptions |
|---|
| BAG-family molecular chaperone regulator-4 2 | | BCL2-associated athanogene 4 2 | | Bcl-2-associated athanogene 4 3 | | Silencer of death domains 2, 3 |
|
| | Search outside databases for aliases for BAG4 genePrevious GC identifers: GC08P037574 GC08P038162 GC08P037775 GC08P038051 |
Summaries for BAG4(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for BAG4: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. [provided by RefSeq] UniProtKB/Swiss-Prot: BAG4_HUMAN, O95429Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signalingGene Wiki entry for BAG4 |
Genomic Location for BAG4
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the BAG4 gene 
Entrez Gene cytogenetic band: 8p12 Ensembl cytogenetic band: 8p12 HGNC cytogenetic band: 8p11.23BAG4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P038153:
(about GC identifiers)
Start:
|
38,153,263 bp from pter |
End:
|
38,189,966 bp from pter |
Size:
|
36,704 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000008.9 NT_007995.14
| Proteins for BAG4
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: BAG4_HUMAN, O95429 (See
protein sequence)Recommended Name: BAG family molecular chaperone regulator 4 Size: 457 amino acids; 49594 Da
Subunit: Binds to the ATPase domain of HSP70/HSC chaperones. Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of TNFRSF12
Subcellular location: Cytoplasm
PDB structure from and Proteopedia :1M62 (3D)
 1M7K (3D)
 
Secondary accessions: O95818Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004865.1
ENSEMBL proteins: ENSP00000287322
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for BAG4: Assays for BAG4: | Protein
Domains/ Families for BAG4(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O95429
ProtoNet protein and cluster: O95429 1 Blocks protein family: IPB003103 Apoptosis regulator Bcl-2 protein
UniProtKB/Swiss-Prot: BAG4_HUMAN, O95429Similarity: Contains 1 BAG domain | Gene Function for BAG4
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004874
Applied Biosystems Silencer® siRNAs for BAG4
Sigma-Aldrich siRNA for BAG4  Sigma-Aldrich shRNA Panels and shRNA for BAG4  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004874                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004874                                  untagged cDNA clone in CMV expression vector: NM_004874 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004874
UniProtKB/Swiss-Prot: BAG4_HUMAN, O95429Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signalingGenatlas biochemistry entry for BAG4:BCL2-associated athanogene 4 (antiapoptotic). Negative regulator of Hsp70 chaperone activity4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Bag4):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for BAG4
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for BAG4 
5/21 Interacting proteins for BAG4 (ENSP000002873223) via UniProtKB, MINT, and/or STRING (see all 21
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for BAG4(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for BAG4
|
Transcripts for BAG4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004874
Sigma-Aldrich siRNA for BAG4  Sigma-Aldrich shRNA Panels and shRNA for BAG4  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004874 REFSEQ mRNAs for BAG4 gene: NM_004874.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004874               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004874                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004874                                  untagged cDNA clone in CMV expression vector: NM_004874  Additional cDNA sequence: AF095194.2 AF111116.1 AK304072.1 AK314020.1 AL049466.1 BC000800.1 BC038505.1 9 DOTS entries: DT.410810 DT.212331 DT.100748873 DT.40273676 DT.116154 DT.97798536 DT.120637283 DT.121476615 DT.120993188 24/93 AceView cDNA sequences (see all 93
):AA707133 AI640615 AI033824 CB151043 Z39301 BU163931 CB528734 CB164521 BC000800 BM677355 AI141948 AI276421 AA804437 BX282256 BM555081 BQ575950 AI167402 AA693697 BE046519 Z43225 AI628947 AI241475 BM725874 AA905269
highest scoring ESTs for BAG4:AI805127 H79217 AA693697 AA707133 AA976160 AF095194 AF111116 AI033283 AI033824 AI141948 Unigene Cluster for BAG4: BCL2-associated athanogene 4 Hs.194726 [show with all ESTs]Unigene Representative Sequence: BC038505
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for BAG4
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for BAG4
1 Ensembl transcript including schematic representation: ENST00000287322
|
Expression for BAG4
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| BAG4 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for BAG4
1 / 2 / 3 9 probe-sets matching BAG4 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.194726 UniProtKB/Swiss-Prot: BAG4_HUMAN, O95429Tissue specificity: Ubiquitous |
Orthologs for BAG4
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BAG4 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for BAG4
ENSEMBL Gene Tree for BAG4 | Paralogs for BAG4(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for BAG4 gene
- BAG52 BAG32
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for BAG4(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for BAG4 (up to first 250kb)
|
Disorders & Mutations for BAG4
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603884
3 Novoseek disease relationships for BAG4 gene
About this table
|
Medical News for BAG4(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for BAG4 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/26 PubMed articles for BAG4 gene (see all 26
):- Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. (PubMed id 9915703)1, 2, 3, 4 Jiang Y....Goeddel D.V. (1999)
- An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PubMed id 9873016)1, 2, 3, 4 Takayama S.... Reed J.C. (1999)
- BAG4/SODD protein contains a short BAG domain. (PubMed id 12058034)1, 3, 4 Briknarova K.... Ely K.R. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing. (PubMed id 14559896)1, 3 Lau P.P. and Chan L. (2003)
- Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants. (PubMed id 12875962)1, 3 Al-Lamki R.S....Bradley J.R. (2003)
- Tumor necrosis factor receptor 1 is an ATPase regulated by silencer of death domain. (PubMed id 11909948)1, 3 Miki K. and Eddy E.M. (2002)
- Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is responsible for radioresistance in human HT-R15 cells. (PubMed id 12017295)1, 3 Eichholtz-Wirth H. and Sagan D. (2002)
- Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein. (PubMed id 11527400)1, 3 Antoku K....Johnson D.E. (2001)
- A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23. (PubMed id 17366557)3 Riley B.M....Murray J.C. (2007)
|
Search for BAG4
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing BAG4
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing BAG4
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BAG4(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for BAG4(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for BAG4:

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Incremental update: 13 Oct 2009
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