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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BAG4 Gene

protein-coding   GIFtS: 62
GCID: GC08P038051

BCL2-Associated Athanogene 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BCL2-Associated Athanogene 41 2     SODD2 3
Silencer Of Death Domains1 2 3     BAG Family Molecular Chaperone Regulator 42
Bcl-2-Associated Athanogene 42 3     BAG-Family Molecular Chaperone Regulator-42
BAG-42 3     

External Ids:    HGNC: 9401   Entrez Gene: 95302   Ensembl: ENSG000001567357   OMIM: 6038845   UniProtKB: O954293   

Export aliases for BAG4 gene to outside databases

Previous GC identifers: GC08P037574 GC08P038162 GC08P037775 GC08P038153 GC08P036568


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BAG4 Gene:
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein
that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2,
Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70
kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone
activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor
receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death
signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo
apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding
distinct isoforms have been identified. (provided by RefSeq, Mar 2011)

GeneCards Summary for BAG4 Gene: 
BAG4 (BCL2-associated athanogene 4) is a protein-coding gene. Diseases associated with BAG4 include monilethrix, and cleft lip +/- cleft palate, and among its related super-pathways are DR3 Signaling and Apoptosis and survival Apoptotic TNF-family pathways. GO annotations related to this gene include receptor signaling protein activity and chaperone binding. An important paralog of this gene is BAG5.

UniProtKB/Swiss-Prot: BAG4_HUMAN, O95429
Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents
constitutive TNFRSF1A signaling

Gene Wiki entry for BAG4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BAG4 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBAG4 promoter sequence
   Search SABiosciences Chromatin IP Primers for BAG4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.23   Ensembl cytogenetic band:  8p11.23   HGNC cytogenetic band: 8p11.23

BAG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAG4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P038051:  view genomic region     (about GC identifiers)

Start:
38,034,051 bp from pter      End:
38,070,819 bp from pter
Size:
36,769 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BAG4_HUMAN, O95429 (See protein sequence)
Recommended Name: BAG family molecular chaperone regulator 4  
Size: 457 amino acids; 49594 Da
Subunit: Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to the death domain of TNFRSF1A in the absence
of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of
TNFRSF12
Subcellular location: Cytoplasm
2 PDB 3D structures from and Proteopedia for BAG4:
1M62 (3D)        1M7K (3D)    
Secondary accessions: B4E217 O95818
Alternative splicing: 2 isoforms:  O95429-1   O95429-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BAG4: NX_O95429

Explore proteomics data for BAG4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95429

  • BAG4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BAG4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001191807.1  NP_004865.1  

    ENSEMBL proteins: 
     ENSP00000393298   ENSP00000287322   ENSP00000430250  

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    Novus Biologicals BAG4 Lysates
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    Cloud-Clone Corp. Proteins for BAG4 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA--
    GO:0005886plasma membrane IDA--

    BAG4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003103 BAG_domain

    Graphical View of Domain Structure for InterPro Entry O95429

    ProtoNet protein and cluster: O95429

    1 Blocks protein domain: IPB003103 Apoptosis regulator Bcl-2 protein

    UniProtKB/Swiss-Prot: BAG4_HUMAN, O95429
    Similarity: Contains 1 BAG domain


    BAG4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BAG4_HUMAN, O95429
    Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents
    constitutive TNFRSF1A signaling

         Genatlas biochemistry entry for BAG4:
    BCL2-associated athanogene 4 (antiapoptotic). Negative regulator of Hsp70 chaperone activity

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity TAS9915703
    GO:0005515protein binding ----
    GO:0051087chaperone binding IEA--
         
    BAG4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BAG4:
     Upregulation of Wnt/beta-caten 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bag4):
     hematopoietic system  homeostasis/metabolism  immune system  normal 

    BAG4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BAG4: Bag4tm1Yeh Bag4tm1Kpf

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BAG4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BAG4

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    SwitchGear 3'UTR luciferase reporter plasmidBAG4 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BAG4 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    TWEAK Pathway0.87
    TNF Signaling0.55
    DR3 Signaling0.87
    Apoptosis and survival TNFR1 signaling pathway0.52
    TNFR1 Pathway0.56
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    2Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis Signaling Pathways0.35
    3TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    4TNF signaling pathway
    TNF signaling pathway
    5TNF receptor signaling pathway
    TNF receptor signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for BAG4
        Apoptosis and survival TNFR1 signaling pathway

    1 R&D Systems Pathway for BAG4
        Apoptosis Signaling Pathways

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BAG4
        TNF Signaling
    TWEAK Pathway
    DR3 Signaling
    TNFR1 Pathway

    1 GeneGo (Thomson Reuters) Pathway for BAG4
        Apoptosis and survival TNFR1 signaling pathway

    4 BioSystems Pathways for BAG4
        TNF-alpha/NF-kB Signaling Pathway
    HIV-1 Nef- Negative effector of Fas and TNF-alpha
    Ceramide signaling pathway
    TNF receptor signaling pathway


    1         Kegg Pathway  (Kegg details for BAG4):
        TNF signaling pathway


    BAG4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BAG4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/62 Interacting proteins for BAG4 (O954293 ENSP000002873224) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS9873016
    GO:0010763positive regulation of fibroblast migration IEA--
    GO:0030838positive regulation of actin filament polymerization IEA--
    GO:0033138positive regulation of peptidyl-serine phosphorylation IEA--
    GO:0043066negative regulation of apoptotic process TAS9915703

    BAG4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BAG4

    Search CenterWatch for drugs/clinical trials and news about BAG4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BAG4 gene (2 alternative transcripts): 
    NM_001204878.1  NM_004874.3  

    Unigene Cluster for BAG4:

    BCL2-associated athanogene 4
    Hs.194726  [show with all ESTs]
    Unigene Representative Sequence: NM_004874
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521282 ENST00000432471 ENST00000287322(uc003xky.2 uc003xkz.2)
    ENST00000521311
    miRNA
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    hsa-miR-3685 hsa-miR-3938 hsa-miR-607 hsa-miR-3655 hsa-miR-4272 hsa-miR-15a hsa-miR-578 hsa-miR-766
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    Additional mRNA sequence: 

    AF095194.2 AF111116.1 AK304072.1 AK314020.1 AL049466.1 BC000800.1 BC038505.1 

    9 DOTS entries:

    DT.410810  DT.212331  DT.100748873  DT.40273676  DT.116154  DT.97798536  DT.120637283  DT.121476615 
    DT.120993188 

    24/93 AceView cDNA sequences (see all 93):

    AI276421 BQ012732 AI924007 BM725874 H53288 AL601642 AI141948 AI167402 
    BU163931 CB151043 CB164521 AI640615 BQ431059 BQ575950 BQ012080 Z39301 
    BM677355 AA707133 AL049466 BC038505 NM_004874 BC000800 Z44215 AI033283 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BAG4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b
    SP1:                                                        -               
    SP2:              -                                                         
    SP3:                          -                             -               
    SP4:                                                                        


    ECgene alternative splicing isoforms for BAG4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BAG4 expression in normal human tissues (normalized intensities)      BAG4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BAG4 Expression
    About this image


    BAG4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             bone marrow cd34+   

    See BAG4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BAG4

    SOURCE GeneReport for Unigene cluster: Hs.194726

    UniProtKB/Swiss-Prot: BAG4_HUMAN, O95429
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Arrays including BAG4: 
              TNF Ligands & Receptors in human mouse rat
              Neurotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAG4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BAG4 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bag41 , 5 BCL2-associated athanogene 41, 5 84.32(n)1
    85.27(a)1
      8 (14.17 cM)5
    673841  NM_026121.31  NP_080397.11 
     257645385 
    chicken
    (Gallus gallus)
    Aves BAG41 BCL2-associated athanogene 4 55.14(n)
    48.13(a)
      426776  XM_424388.3  XP_424388.3 
    lizard
    (Anolis carolinensis)
    Reptilia BAG46
    Uncharacterized protein
    41(a)
    1 ↔ 1
    GL343406.1(790678-804075)
    zebrafish
    (Danio rerio)
    Actinopterygii wufd20a042 Transcribed sequence with weak similarity to protein more 72.4(n)    AL906504.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta stv6
    starvin
    14(a)
    1 → many
    3L(13470641-13476615)


    ENSEMBL Gene Tree for BAG4 (if available)
    TreeFam Gene Tree for BAG4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BAG4 gene
    BAG52  BAG32  

    BAG4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BAG4
    PGOHUM00000249378


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/643 SNPs in BAG4 are shown (see all 643)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1427843851,2
    --36566613(+) ACTGTA/GTGTTA 2 -- us2k10--------
    rs1474322821,2
    --36566641(+) GTGCAC/TATCAA 2 -- us2k10--------
    rs1382404911,2
    --36566686(+) GAATCC/TACAAA 2 -- us2k10--------
    rs27200511,2
    C,F,H--36566709(+) AGAGGG/ACCAAA 2 -- us2k1 tfbs323Minor allele frequency- A:0.08NS EA NA WA CSA 1834
    rs1841212801,2
    --36566762(+) GATATA/GTAAGG 2 -- us2k10--------
    rs1840149571,2
    C--38036321(+) CTGGCC/GGTGTA 2 -- int10--------
    rs1452094511,2
    C--38036375(+) GGGCCC/TGGTGA 2 -- int10--------
    rs1135083181,2
    C--38036494(+) AAATAAAAA    
       AAT
    /-
    AAAAA
    2 -- int11Minor allele frequency- -:0.00CSA 2
    rs1889067181,2
    C--38036595(+) AAAAGG/TGTAGA 2 -- int10--------
    rs1402693681,2
    C--38036668(+) ATAAA-/TTATT 
    TTTTATTT
    TTATT
    2 -- int10--------

    HapMap Linkage Disequilibrium report for BAG4 (38034051 - 38070819 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BAG4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv397579CNV Loss16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603884    OMIM disorders: --

    11 diseases for BAG4:    About MalaCards
    monilethrix    cleft lip +/- cleft palate    cleft palate    cleft lip
    hodgkin's lymphoma    non-hodgkin lymphoma    multiple sclerosis    pancreatic cancer
    pancreatitis    leukemia    breast cancer

    1 disease from the University of Copenhagen DISEASES database for BAG4:
    Monilethrix

    BAG4 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for BAG4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 35.2 2 11527400 (1), 10339421 (1)
    leukemia 19.6 5 17605853 (2), 17641854 (1)
    tumors 7.62 2 11527400 (1), 10339421 (1)

    Genetic Association Database (GAD): BAG4
    Human Genome Epidemiology (HuGE) Navigator: BAG4 (4 documents)

    Export disorders for BAG4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BAG4 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with BAG4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. (PubMed id 9915703)1, 2, 3, 9 Jiang Y....Goeddel D.V. (1999)
    2. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PubMed id 9873016)1, 2, 3, 9 Takayama S.... Reed J.C. (1999)
    3. BAG4/SODD protein contains a short BAG domain. (PubMed id 12058034)1, 2, 9 Briknarova K.... Ely K.R. (2002)
    4. Germline variation in apoptosis pathway genes and ris k of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing. (PubMed id 14559896)1, 9 Lau P.P. and Chan L. (2003)
    8. [Effects of SODD and survivin on leukemia cell apoptosis induced by chemotherapeutic drugs] (PubMed id 17605853)1, 9 Tao H.F....Hu Y. (2007)
    9. Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants. (PubMed id 12875962)1, 9 Al-Lamki R.S....Bradley J.R. (2003)
    10. Tumor necrosis factor receptor 1 is an ATPase regulated by silencer of death domain. (PubMed id 11909948)1, 9 Miki K. and Eddy E.M. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9530 HGNC: 940 AceView: BAG4 Ensembl:ENSG00000156735 euGenes: HUgn9530
    ECgene: BAG4 Kegg: 9530 H-InvDB: BAG4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BAG4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BAG4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BAG4 gene:
    Search GeneIP for patents involving BAG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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