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Aliases for BAG4 Gene

Aliases for BAG4 Gene

  • BCL2 Associated Athanogene 4 2 3 5
  • Silencer Of Death Domains 2 3 4
  • Bcl-2-Associated Athanogene 4 3 4
  • BAG-4 3 4
  • SODD 3 4
  • BAG-Family Molecular Chaperone Regulator-4 3
  • BCL2-Associated Athanogene 4 3

External Ids for BAG4 Gene

Previous GeneCards Identifiers for BAG4 Gene

  • GC08P037574
  • GC08P038162
  • GC08P037775
  • GC08P038051
  • GC08P038153
  • GC08P036568

Summaries for BAG4 Gene

Entrez Gene Summary for BAG4 Gene

  • The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

GeneCards Summary for BAG4 Gene

BAG4 (BCL2 Associated Athanogene 4) is a Protein Coding gene. Among its related pathways are TWEAK Pathway and TNF signaling pathway. GO annotations related to this gene include poly(A) RNA binding and receptor signaling protein activity. An important paralog of this gene is BAG5.

UniProtKB/Swiss-Prot for BAG4 Gene

  • Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PARK2 translocation to damaged mitochondria.

Gene Wiki entry for BAG4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG4 Gene

Genomics for BAG4 Gene

Regulatory Elements for BAG4 Gene

Enhancers for BAG4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BAG4 on UCSC Golden Path with GeneCards custom track

Promoters for BAG4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BAG4 on UCSC Golden Path with GeneCards custom track

Genomic Location for BAG4 Gene

38,176,533 bp from pter
38,213,301 bp from pter
36,769 bases
Plus strand

Genomic View for BAG4 Gene

Genes around BAG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG4 Gene

Proteins for BAG4 Gene

  • Protein details for BAG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BAG family molecular chaperone regulator 4
    Protein Accession:
    Secondary Accessions:
    • B4E217
    • O95818

    Protein attributes for BAG4 Gene

    457 amino acids
    Molecular mass:
    49594 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of TNFRSF12. Interacts with PARK2.

    Three dimensional structures from OCA and Proteopedia for BAG4 Gene

    Alternative splice isoforms for BAG4 Gene


neXtProt entry for BAG4 Gene

Proteomics data for BAG4 Gene at MOPED

Post-translational modifications for BAG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BAG4 Gene

Antibody Products

No data available for DME Specific Peptides for BAG4 Gene

Domains & Families for BAG4 Gene

Gene Families for BAG4 Gene

Protein Domains for BAG4 Gene

Suggested Antigen Peptide Sequences for BAG4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BAG domain.
  • Contains 1 BAG domain.
genes like me logo Genes that share domains with BAG4: view

Function for BAG4 Gene

Molecular function for BAG4 Gene

GENATLAS Biochemistry:
BCL2-associated athanogene 4 (antiapoptotic). Negative regulator of Hsp70 chaperone activity
UniProtKB/Swiss-Prot Function:
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PARK2 translocation to damaged mitochondria.
genes like me logo Genes that share phenotypes with BAG4: view

Animal Models for BAG4 Gene

MGI Knock Outs for BAG4:

Animal Model Products

miRNA for BAG4 Gene

miRTarBase miRNAs that target BAG4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BAG4 Gene

Localization for BAG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAG4 Gene


Subcellular locations from

Jensen Localization Image for BAG4 Gene COMPARTMENTS Subcellular localization image for BAG4 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for BAG4 Gene

Pathways & Interactions for BAG4 Gene

genes like me logo Genes that share pathways with BAG4: view

Gene Ontology (GO) - Biological Process for BAG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9873016
GO:0010763 positive regulation of fibroblast migration IEA --
GO:0030838 positive regulation of actin filament polymerization IEA --
GO:0034605 cellular response to heat TAS --
GO:0043066 negative regulation of apoptotic process TAS 9915703
genes like me logo Genes that share ontologies with BAG4: view

No data available for SIGNOR curated interactions for BAG4 Gene

Drugs & Compounds for BAG4 Gene

No Compound Related Data Available

Transcripts for BAG4 Gene

Unigene Clusters for BAG4 Gene

BCL2-associated athanogene 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BAG4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: -
SP3: - -

Relevant External Links for BAG4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BAG4 Gene

mRNA expression in normal human tissues for BAG4 Gene

Protein differential expression in normal tissues from HIPED for BAG4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAG4 Gene

SOURCE GeneReport for Unigene cluster for BAG4 Gene Hs.194726

mRNA Expression by UniProt/SwissProt for BAG4 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with BAG4: view

Protein tissue co-expression partners for BAG4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BAG4 Gene

Orthologs for BAG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BAG4 35
  • 87.45 (n)
  • 86.87 (a)
BAG4 36
  • 87 (a)
(Canis familiaris)
Mammalia BAG4 35
  • 88.62 (n)
  • 88.4 (a)
BAG4 36
  • 88 (a)
(Mus musculus)
Mammalia Bag4 35
  • 84.25 (n)
  • 85.05 (a)
Bag4 16
Bag4 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Bag4 35
  • 84.62 (n)
  • 86.15 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
-- 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia BAG4 36
  • 65 (a)
(Pan troglodytes)
Mammalia BAG4 36
  • 100 (a)
(Gallus gallus)
Aves BAG4 35
  • 56.06 (n)
  • 50.65 (a)
BAG4 36
  • 41 (a)
(Anolis carolinensis)
Reptilia BAG4 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bag4 35
  • 50.4 (n)
  • 39.88 (a)
(Danio rerio)
Actinopterygii wufd20a04 35
bag4 36
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta stv 36
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5020 36
  • 20 (a)
Species with no ortholog for BAG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAG4 Gene

Gene Tree for BAG4 (if available)
Gene Tree for BAG4 (if available)

Paralogs for BAG4 Gene

Paralogs for BAG4 Gene Pseudogenes for BAG4 Gene

genes like me logo Genes that share paralogs with BAG4: view

Variants for BAG4 Gene

Sequence variations from dbSNP and Humsavar for BAG4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7830233 -- 38,181,192(+) cgcct(C/T)ggctg intron-variant
rs7836805 -- 38,205,717(+) TTATA(A/C)CTCAT intron-variant
rs9694158 -- 38,198,469(+) taagg(G/T)ttttt intron-variant
rs10090924 -- 38,200,335(+) aaatg(G/T)aaggg intron-variant
rs10092024 -- 38,201,880(+) tatat(A/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAG4 Gene

Variant ID Type Subtype PubMed ID
nsv397579 CNV Loss 16902084

Variation tolerance for BAG4 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BAG4 Gene

Disorders for BAG4 Gene

Relevant External Links for BAG4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BAG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BAG4 Gene

Publications for BAG4 Gene

  1. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. (PMID: 9915703) Jiang Y. … Goeddel D.V. (Science 1999) 2 3 4 23 67
  2. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S. … Reed J.C. (J. Biol. Chem. 1999) 2 3 23
  3. [Effects of SODD and survivin on leukemia cell apoptosis induced by chemotherapeutic drugs]. (PMID: 17605853) Tao H.F. … Hu Y. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007) 3 23
  4. Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants. (PMID: 12875962) Al-Lamki R.S. … Bradley J.R. (Am. J. Pathol. 2003) 3 23
  5. Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing. (PMID: 14559896) Lau P.P. … Chan L. (J. Biol. Chem. 2003) 3 23

Products for BAG4 Gene

Sources for BAG4 Gene