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Aliases for BAG4 Gene

Aliases for BAG4 Gene

  • BCL2-Associated Athanogene 4 2 3
  • Silencer Of Death Domains 2 3 4
  • SODD 3 4 6
  • Bcl-2-Associated Athanogene 4 3 4
  • BAG-4 3 4
  • BAG Family Molecular Chaperone Regulator 4 3
  • BAG-Family Molecular Chaperone Regulator-4 3

External Ids for BAG4 Gene

Previous GeneCards Identifiers for BAG4 Gene

  • GC08P037574
  • GC08P038162
  • GC08P037775
  • GC08P038051
  • GC08P038153
  • GC08P036568

Summaries for BAG4 Gene

Entrez Gene Summary for BAG4 Gene

  • The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

GeneCards Summary for BAG4 Gene

BAG4 (BCL2-Associated Athanogene 4) is a Protein Coding gene. Diseases associated with BAG4 include monilethrix. Among its related pathways are Apoptosis Signaling Pathways and TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include chaperone binding and receptor signaling protein activity. An important paralog of this gene is BAG5.

UniProtKB/Swiss-Prot for BAG4 Gene

  • Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PARK2 translocation to damaged mitochondria.

Gene Wiki entry for BAG4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG4 Gene

Genomics for BAG4 Gene

Regulatory Elements for BAG4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BAG4 Gene

Start:
38,176,533 bp from pter
End:
38,213,301 bp from pter
Size:
36,769 bases
Orientation:
Plus strand

Genomic View for BAG4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG4 Gene

Proteins for BAG4 Gene

  • Protein details for BAG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95429-BAG4_HUMAN
    Recommended name:
    BAG family molecular chaperone regulator 4
    Protein Accession:
    O95429
    Secondary Accessions:
    • B4E217
    • O95818

    Protein attributes for BAG4 Gene

    Size:
    457 amino acids
    Molecular mass:
    49594 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of TNFRSF12. Interacts with PARK2.

    Three dimensional structures from OCA and Proteopedia for BAG4 Gene

    Alternative splice isoforms for BAG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAG4 Gene

Proteomics data for BAG4 Gene at MOPED

Post-translational modifications for BAG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BAG4 Gene

No data available for DME Specific Peptides for BAG4 Gene

Domains for BAG4 Gene

Protein Domains for BAG4 Gene

Suggested Antigen Peptide Sequences for BAG4 Gene

Graphical View of Domain Structure for InterPro Entry

O95429

UniProtKB/Swiss-Prot:

BAG4_HUMAN :
  • O95429
Domain:
  • Contains 1 BAG domain.
genes like me logo Genes that share domains with BAG4: view

No data available for Gene Families for BAG4 Gene

Function for BAG4 Gene

Molecular function for BAG4 Gene

GENATLAS Biochemistry: BCL2-associated athanogene 4 (antiapoptotic). Negative regulator of Hsp70 chaperone activity
UniProtKB/Swiss-Prot Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PARK2 translocation to damaged mitochondria.

Gene Ontology (GO) - Molecular Function for BAG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity TAS 9915703
GO:0005515 protein binding IPI 25036637
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with BAG4: view
genes like me logo Genes that share phenotypes with BAG4: view

Animal Models for BAG4 Gene

MGI Knock Outs for BAG4:

Animal Model Products

CRISPR Products

miRNA for BAG4 Gene

miRTarBase miRNAs that target BAG4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BAG4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BAG4 Gene

Localization for BAG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAG4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAG4 Gene COMPARTMENTS Subcellular localization image for BAG4 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for BAG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21712384
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA 21712384
genes like me logo Genes that share ontologies with BAG4: view

Pathways for BAG4 Gene

genes like me logo Genes that share pathways with BAG4: view

Pathways by source for BAG4 Gene

1 GeneGo (Thomson Reuters) pathway for BAG4 Gene
1 R&D Systems pathway for BAG4 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for BAG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9873016
GO:0007166 cell surface receptor signaling pathway TAS --
GO:0010763 positive regulation of fibroblast migration IEA --
GO:0030838 positive regulation of actin filament polymerization IEA --
GO:0033138 positive regulation of peptidyl-serine phosphorylation IEA --
genes like me logo Genes that share ontologies with BAG4: view

Transcripts for BAG4 Gene

Unigene Clusters for BAG4 Gene

BCL2-associated athanogene 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BAG4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAG4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for BAG4 Gene

GeneLoc Exon Structure for
BAG4
ECgene alternative splicing isoforms for
BAG4

Expression for BAG4 Gene

mRNA expression in normal human tissues for BAG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAG4 Gene

SOURCE GeneReport for Unigene cluster for BAG4 Gene Hs.194726

mRNA Expression by UniProt/SwissProt for BAG4 Gene

O95429-BAG4_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with BAG4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BAG4 Gene

Orthologs for BAG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAG4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAG4 35
  • 87.45 (n)
  • 86.87 (a)
BAG4 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAG4 35
  • 88.62 (n)
  • 88.4 (a)
BAG4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bag4 35
  • 84.25 (n)
  • 85.05 (a)
Bag4 16
Bag4 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia BAG4 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bag4 35
  • 84.62 (n)
  • 86.15 (a)
chicken
(Gallus gallus)
Aves BAG4 35
  • 56.06 (n)
  • 50.65 (a)
BAG4 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BAG4 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bag4 35
  • 50.4 (n)
  • 39.88 (a)
zebrafish
(Danio rerio)
Actinopterygii bag4 36
  • 34 (a)
OneToOne
wufd20a04 35
fruit fly
(Drosophila melanogaster)
Insecta stv 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5020 36
  • 20 (a)
OneToMany
Species with no ortholog for BAG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAG4 Gene

ENSEMBL:
Gene Tree for BAG4 (if available)
TreeFam:
Gene Tree for BAG4 (if available)

Paralogs for BAG4 Gene

Paralogs for BAG4 Gene

Pseudogenes.org Pseudogenes for BAG4 Gene

genes like me logo Genes that share paralogs with BAG4: view

Variants for BAG4 Gene

Sequence variations from dbSNP and Humsavar for BAG4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3313 -- 38,210,902(-) TGTAC(A/G)AAAAT utr-variant-3-prime
rs10725 -- 38,210,353(-) TTCCA(A/G)AAGCC reference, synonymous-codon
rs1043782 -- 38,210,806(+) TCACA(C/T)AACAG utr-variant-3-prime
rs4259388 -- 38,194,061(+) gagat(A/G)gggtt intron-variant
rs4379415 -- 38,197,668(+) aaata(C/T)tgtaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAG4 Gene

Variant ID Type Subtype PubMed ID
nsv397579 CNV Loss 16902084

Relevant External Links for BAG4 Gene

HapMap Linkage Disequilibrium report
BAG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG4 Gene

Disorders for BAG4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BAG4 Gene including...

Search for BAG4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for BAG4 Gene

(3) Novoseek inferred disease relationships for BAG4 Gene

Disease -log(P) Hits PubMed IDs
necrosis 35.2 2
leukemia 19.6 3
tumors 7.62 2

Relevant External Links for BAG4

Genetic Association Database (GAD)
BAG4
Human Genome Epidemiology (HuGE) Navigator
BAG4
genes like me logo Genes that share disorders with BAG4: view

No data available for UniProtKB/Swiss-Prot for BAG4 Gene

Publications for BAG4 Gene

  1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S. … Reed J.C. (J. Biol. Chem. 1999) 2 3 4 23
  2. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. (PMID: 9915703) Jiang Y. … Goeddel D.V. (Science 1999) 2 3 4 23
  3. BAG4/SODD protein contains a short BAG domain. (PMID: 12058034) Briknarova K. … Ely K.R. (J. Biol. Chem. 2002) 3 4 23
  4. Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants. (PMID: 12875962) Al-Lamki R.S. … Bradley J.R. (Am. J. Pathol. 2003) 3 23
  5. Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing. (PMID: 14559896) Lau P.P. … Chan L. (J. Biol. Chem. 2003) 3 23

Products for BAG4 Gene

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