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Aliases for BAG4 Gene

Aliases for BAG4 Gene

  • BCL2 Associated Athanogene 4 2 3 5
  • Silencer Of Death Domains 2 3 4
  • Bcl-2-Associated Athanogene 4 3 4
  • BAG-4 3 4
  • SODD 3 4
  • BAG Family Molecular Chaperone Regulator 4 3

External Ids for BAG4 Gene

Previous GeneCards Identifiers for BAG4 Gene

  • GC08P037574
  • GC08P038162
  • GC08P037775
  • GC08P038051
  • GC08P038153
  • GC08P036568

Summaries for BAG4 Gene

Entrez Gene Summary for BAG4 Gene

  • The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

GeneCards Summary for BAG4 Gene

BAG4 (BCL2 Associated Athanogene 4) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and TNFR1 Pathway. GO annotations related to this gene include poly(A) RNA binding and signal transducer activity, downstream of receptor. An important paralog of this gene is BAG3.

UniProtKB/Swiss-Prot for BAG4 Gene

  • Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PARK2 translocation to damaged mitochondria.

Gene Wiki entry for BAG4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG4 Gene

Genomics for BAG4 Gene

Regulatory Elements for BAG4 Gene

Enhancers for BAG4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F037550 1.2 Ensembl ENCODE 9.8 -623.9 -623949 4.0 PKNOX1 KLF17 ARID4B FEZF1 RAD21 RARA ZNF121 SCRT2 CREM EGR2 DDHD2 BAG4 LINC01605 ENSG00000253414
GH08F038175 1.7 FANTOM5 Ensembl ENCODE 2 +1.0 1000 4.9 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS ENSG00000254306 DDHD2 LETM2 LOC102723716 FGFR1 BAG4 NSD3 LSM1 GC08M038027
GH08F037879 1.5 FANTOM5 ENCODE 1.2 -292.7 -292673 8.2 HDGF PKNOX1 WRNIP1 SIN3A ZNF2 YY1 ZNF207 FOS JUNB TBX21 RAB11FIP1 NSD3 BAG4 ENSG00000280064
GH08F038170 1.4 Ensembl ENCODE 0.8 -3.7 -3688 3.8 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 RPS20P22 DDHD2 LOC100507403 LOC102723716 LETM2 ENSG00000254290 BAG4 GC08M038168 RNU6-323P
GH08F038165 1 ENCODE 0.4 -9.7 -9679 2.3 PKNOX1 ATF1 ARID4B DMAP1 YY1 ZNF121 GATA2 MXD4 MIER2 PPARG DDHD2 GC08M038168 RNU6-323P BAG4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BAG4 on UCSC Golden Path with GeneCards custom track

Promoters for BAG4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001390109 467 4001 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS

Genomic Location for BAG4 Gene

Chromosome:
8
Start:
38,176,533 bp from pter
End:
38,213,301 bp from pter
Size:
36,769 bases
Orientation:
Plus strand

Genomic View for BAG4 Gene

Genes around BAG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG4 Gene

Proteins for BAG4 Gene

  • Protein details for BAG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95429-BAG4_HUMAN
    Recommended name:
    BAG family molecular chaperone regulator 4
    Protein Accession:
    O95429
    Secondary Accessions:
    • B4E217
    • O95818

    Protein attributes for BAG4 Gene

    Size:
    457 amino acids
    Molecular mass:
    49594 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of TNFRSF12. Interacts with PARK2.

    Three dimensional structures from OCA and Proteopedia for BAG4 Gene

    Alternative splice isoforms for BAG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAG4 Gene

Post-translational modifications for BAG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BAG4 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for BAG4

No data available for DME Specific Peptides for BAG4 Gene

Domains & Families for BAG4 Gene

Gene Families for BAG4 Gene

Protein Domains for BAG4 Gene

Suggested Antigen Peptide Sequences for BAG4 Gene

Graphical View of Domain Structure for InterPro Entry

O95429

UniProtKB/Swiss-Prot:

BAG4_HUMAN :
  • Contains 1 BAG domain.
Domain:
  • Contains 1 BAG domain.
genes like me logo Genes that share domains with BAG4: view

Function for BAG4 Gene

Molecular function for BAG4 Gene

GENATLAS Biochemistry:
BCL2-associated athanogene 4 (antiapoptotic). Negative regulator of Hsp70 chaperone activity
UniProtKB/Swiss-Prot Function:
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PARK2 translocation to damaged mitochondria.

Gene Ontology (GO) - Molecular Function for BAG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity TAS --
GO:0005057 signal transducer activity, downstream of receptor TAS 9915703
GO:0005515 protein binding IPI 25036637
GO:0031625 ubiquitin protein ligase binding IPI 24270810
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with BAG4: view
genes like me logo Genes that share phenotypes with BAG4: view

Animal Models for BAG4 Gene

MGI Knock Outs for BAG4:

Animal Model Products

miRNA for BAG4 Gene

miRTarBase miRNAs that target BAG4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BAG4 Gene

Localization for BAG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAG4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BAG4 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for BAG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21712384
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
GO:0005886 plasma membrane IDA 21712384
genes like me logo Genes that share ontologies with BAG4: view

Pathways & Interactions for BAG4 Gene

genes like me logo Genes that share pathways with BAG4: view

Pathways by source for BAG4 Gene

Gene Ontology (GO) - Biological Process for BAG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9873016
GO:0010763 positive regulation of fibroblast migration IEA --
GO:0030838 positive regulation of actin filament polymerization IEA --
GO:0033138 positive regulation of peptidyl-serine phosphorylation IEA --
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with BAG4: view

No data available for SIGNOR curated interactions for BAG4 Gene

Transcripts for BAG4 Gene

Unigene Clusters for BAG4 Gene

BCL2-associated athanogene 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAG4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for BAG4 Gene

GeneLoc Exon Structure for
BAG4
ECgene alternative splicing isoforms for
BAG4

Expression for BAG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BAG4 Gene

Protein differential expression in normal tissues from HIPED for BAG4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BAG4 Gene



Protein tissue co-expression partners for BAG4 Gene

NURSA nuclear receptor signaling pathways regulating expression of BAG4 Gene:

BAG4

SOURCE GeneReport for Unigene cluster for BAG4 Gene:

Hs.194726

mRNA Expression by UniProt/SwissProt for BAG4 Gene:

O95429-BAG4_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with BAG4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BAG4 Gene

Orthologs for BAG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAG4 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAG4 34 35
  • 88.62 (n)
cow
(Bos Taurus)
Mammalia BAG4 34 35
  • 87.45 (n)
rat
(Rattus norvegicus)
Mammalia Bag4 34
  • 84.62 (n)
mouse
(Mus musculus)
Mammalia Bag4 34 16 35
  • 84.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BAG4 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 61 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves BAG4 34 35
  • 56.06 (n)
lizard
(Anolis carolinensis)
Reptilia BAG4 35
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bag4 34
  • 50.4 (n)
zebrafish
(Danio rerio)
Actinopterygii bag4 35
  • 34 (a)
OneToOne
wufd20a04 34
fruit fly
(Drosophila melanogaster)
Insecta stv 35
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5020 35
  • 20 (a)
OneToMany
Species where no ortholog for BAG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAG4 Gene

ENSEMBL:
Gene Tree for BAG4 (if available)
TreeFam:
Gene Tree for BAG4 (if available)

Paralogs for BAG4 Gene

Paralogs for BAG4 Gene

Pseudogenes.org Pseudogenes for BAG4 Gene

genes like me logo Genes that share paralogs with BAG4: view

Variants for BAG4 Gene

Sequence variations from dbSNP and Humsavar for BAG4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10090924 -- 38,200,335(+) aaatg(G/T)aaggg intron-variant
rs10092024 -- 38,201,880(+) tatat(A/T)ttttt intron-variant
rs10099466 -- 38,202,873(+) TAATA(G/T)GTAAC intron-variant
rs10099971 -- 38,175,958(+) GAAGC(A/C)CCCCC intron-variant, upstream-variant-2KB
rs10101301 -- 38,188,031(+) gactc(C/T)gtctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAG4 Gene

Variant ID Type Subtype PubMed ID
dgv7162n100 CNV gain 25217958
dgv7163n100 CNV gain 25217958
dgv7164n100 CNV gain 25217958
dgv7165n100 CNV loss 25217958
esv3421040 CNV insertion 20981092
esv3430937 CNV insertion 20981092
nsv1117823 CNV deletion 24896259
nsv397579 CNV deletion 16902084
nsv967580 CNV duplication 23825009

Variation tolerance for BAG4 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BAG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BAG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG4 Gene

Disorders for BAG4 Gene

Relevant External Links for BAG4

Genetic Association Database (GAD)
BAG4
Human Genome Epidemiology (HuGE) Navigator
BAG4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BAG4

No disorders were found for BAG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BAG4 Gene

Publications for BAG4 Gene

  1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S. … Reed J.C. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. (PMID: 9915703) Jiang Y. … Goeddel D.V. (Science 1999) 2 3 4 22 64
  3. BAG4/SODD protein contains a short BAG domain. (PMID: 12058034) Briknarova K. … Ely K.R. (J. Biol. Chem. 2002) 3 4 22 64
  4. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3 4 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for BAG4 Gene

Sources for BAG4 Gene

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