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Aliases for BAG3 Gene

Aliases for BAG3 Gene

  • BCL2 Associated Athanogene 3 2 3 5
  • Bcl-2-Binding Protein Bis 3 4
  • Docking Protein CAIR-1 3 4
  • BAG-3 3 4
  • BIS 3 4
  • BAG Family Molecular Chaperone Regulator 3 3
  • Bcl-2-Associated Athanogene 3 4
  • BCL2-Binding Athanogene 3 3
  • CAIR-1 3
  • MFM6 3

External Ids for BAG3 Gene

Previous GeneCards Identifiers for BAG3 Gene

  • GC10P120329
  • GC10P120654
  • GC10P121542
  • GC10P121075
  • GC10P121400
  • GC10P115040

Summaries for BAG3 Gene

Entrez Gene Summary for BAG3 Gene

  • BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAG3 Gene

BAG3 (BCL2 Associated Athanogene 3) is a Protein Coding gene. Diseases associated with BAG3 include Myopathy, Myofibrillar, 6 and Cardiomyopathy, Dilated, 1Hh. Among its related pathways are Cellular response to heat stress and Cellular Senescence. GO annotations related to this gene include protein complex binding and chaperone binding. An important paralog of this gene is BAG4.

UniProtKB/Swiss-Prot for BAG3 Gene

  • Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.

Gene Wiki entry for BAG3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG3 Gene

Genomics for BAG3 Gene

Regulatory Elements for BAG3 Gene

Enhancers for BAG3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F119686 1.3 Ensembl ENCODE 23.3 +36.6 36571 3.8 HDGF PKNOX1 ARID4B FEZF1 ZNF2 YY1 ZNF143 ZNF207 FOS KLF13 BAG3 TXNP1 INPP5F
GH10F119663 1.3 Ensembl ENCODE 14.9 +16.1 16096 8.9 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF121 ZNF766 GLIS2 RPL17P36 BAG3 SEC23IP PHACTR2P1 RPL21P16 INPP5F TXNP1
GH10F119618 0.9 Ensembl ENCODE 17.5 -31.6 -31646 3.0 GATA3 MAZ HLF CEBPB PRDM10 REST SP7 SPI1 INPP5F BAG3 TIAL1 RAD1P1 GC10P119612
GH10F119703 1.5 FANTOM5 Ensembl ENCODE 6.4 +54.2 54232 4.1 HDGF TBP PKNOX1 TBL1XR1 BMI1 ZBTB40 CBX5 ZNF143 ETV6 CREM BAG3 INPP5F GC10P119719
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BAG3 on UCSC Golden Path with GeneCards custom track

Promoters for BAG3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001404685 753 3401 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 GLIS2 ELK1 FOS

Genomic Location for BAG3 Gene

119,651,347 bp from pter
119,677,819 bp from pter
26,473 bases
Plus strand

Genomic View for BAG3 Gene

Genes around BAG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG3 Gene

Proteins for BAG3 Gene

  • Protein details for BAG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BAG family molecular chaperone regulator 3
    Protein Accession:
    Secondary Accessions:
    • A8K5L8
    • Q3B763
    • Q9NT20
    • Q9P120

    Protein attributes for BAG3 Gene

    575 amino acids
    Molecular mass:
    61595 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to Bcl-2 and PLC-gamma. Interacts with DNAJB6.

neXtProt entry for BAG3 Gene

Post-translational modifications for BAG3 Gene

  • Ubiquitination at Lys 450
  • Modification sites at PhosphoSitePlus

Other Protein References for BAG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for BAG3

No data available for DME Specific Peptides for BAG3 Gene

Domains & Families for BAG3 Gene

Gene Families for BAG3 Gene

Protein Domains for BAG3 Gene

Suggested Antigen Peptide Sequences for BAG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BAG domain.
  • Contains 1 BAG domain.
  • Contains 2 WW domains.
genes like me logo Genes that share domains with BAG3: view

Function for BAG3 Gene

Molecular function for BAG3 Gene

UniProtKB/Swiss-Prot Function:
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.

Gene Ontology (GO) - Molecular Function for BAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IPI 16189514
GO:0032403 protein complex binding IEA --
GO:0051087 chaperone binding IEA --
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with BAG3: view
genes like me logo Genes that share phenotypes with BAG3: view

Human Phenotype Ontology for BAG3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for BAG3 Gene

MGI Knock Outs for BAG3:

Animal Model Products

  • Taconic Biosciences Mouse Models for BAG3

miRNA for BAG3 Gene

miRTarBase miRNAs that target BAG3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BAG3 Gene

Localization for BAG3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BAG3 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 2
extracellular 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA,TAS --
GO:0005886 plasma membrane IDA --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with BAG3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BAG3 Gene

Pathways & Interactions for BAG3 Gene

genes like me logo Genes that share pathways with BAG3: view

Pathways by source for BAG3 Gene

SIGNOR curated interactions for BAG3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding NAS 9873016
GO:0006915 apoptotic process IEA --
GO:0007420 brain development IEA --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IDA 10597216
GO:0010664 negative regulation of striated muscle cell apoptotic process IEA --
genes like me logo Genes that share ontologies with BAG3: view

Transcripts for BAG3 Gene

mRNA/cDNA for BAG3 Gene

Unigene Clusters for BAG3 Gene

BCL2-associated athanogene 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAG3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: - -

Relevant External Links for BAG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BAG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BAG3 Gene

mRNA differential expression in normal tissues according to GTEx for BAG3 Gene

This gene is overexpressed in Muscle - Skeletal (x8.1).

Protein differential expression in normal tissues from HIPED for BAG3 Gene

This gene is overexpressed in Bone (21.6) and Bone marrow stromal cell (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BAG3 Gene

Protein tissue co-expression partners for BAG3 Gene

NURSA nuclear receptor signaling pathways regulating expression of BAG3 Gene:


SOURCE GeneReport for Unigene cluster for BAG3 Gene:

genes like me logo Genes that share expression patterns with BAG3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BAG3 Gene

Orthologs for BAG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BAG3 34 35
  • 99.42 (n)
(Rattus norvegicus)
Mammalia Bag3 34
  • 86.34 (n)
(Mus musculus)
Mammalia Bag3 34 16 35
  • 85.29 (n)
(Canis familiaris)
Mammalia BAG3 34 35
  • 85.16 (n)
(Bos Taurus)
Mammalia BAG3 34 35
  • 85.15 (n)
(Ornithorhynchus anatinus)
Mammalia BAG3 35
  • 58 (a)
(Monodelphis domestica)
Mammalia BAG3 35
  • 53 (a)
(Gallus gallus)
Aves BAG3 34 35
  • 65.31 (n)
(Anolis carolinensis)
Reptilia BAG3 35
  • 49 (a)
African clawed frog
(Xenopus laevis)
Amphibia bag3-A 34
(Danio rerio)
Actinopterygii bag3 34 35
  • 52.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta stv 35
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5020 35
  • 28 (a)
Species where no ortholog for BAG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAG3 Gene

Gene Tree for BAG3 (if available)
Gene Tree for BAG3 (if available)

Paralogs for BAG3 Gene

Paralogs for BAG3 Gene

genes like me logo Genes that share paralogs with BAG3: view

Variants for BAG3 Gene

Sequence variations from dbSNP and Humsavar for BAG3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs121918312 Myopathy, myofibrillar, 6 (MFM6) [MIM:612954], Pathogenic 119,672,373(+) CATTC(A/C/T)GGTGA reference, missense
rs387906874 Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881], Pathogenic 119,669,881(+) CTTCC(C/T)GGGAG reference, missense
rs387906876 Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881], Pathogenic 119,676,984(+) TGTGC(A/G)TCAGG reference, missense
rs397514506 Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881], Pathogenic 119,672,399(+) TTACC(C/T)GGCCA reference, missense
rs397514507 Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881], Pathogenic 119,676,939(+) AGAGC(C/T)GCTGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for BAG3 Gene

Variant ID Type Subtype PubMed ID
nsv825585 CNV gain 20364138
nsv522347 CNV loss 19592680
nsv1045668 CNV gain 25217958
esv3891891 CNV gain 25118596
esv3624708 CNV loss 21293372

Variation tolerance for BAG3 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.63; 89.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BAG3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG3 Gene

Disorders for BAG3 Gene

MalaCards: The human disease database

(10) MalaCards diseases for BAG3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
myopathy, myofibrillar, 6
  • myofibrillar myopathy 6
cardiomyopathy, dilated, 1hh
  • dilated cardiomyopathy 1hh
dilated cardiomyopathy
  • congestive cardiomyopathy
bag3-related dilated cardiomyopathy
  • cardiomyopathy, dilated, 1hh
familial isolated dilated cardiomyopathy
  • familial or idiopathic dilated cardiomyopathy
- elite association - COSMIC cancer census association via MalaCards
Search BAG3 in MalaCards View complete list of genes associated with diseases


  • Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269 PubMed:21353195, ECO:0000269 PubMed:21459883, ECO:0000269 PubMed:21898660}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Myopathy, myofibrillar, 6 (MFM6) [MIM:612954]: A form of myofibrillar myopathy, a group of chronic neuromuscular disorders characterized at ultrastructural level by disintegration of the sarcomeric Z disc and myofibrils, and replacement of the normal myofibrillar markings by small dense granules, or larger hyaline masses, or amorphous material. MFM6 is characterized by early-onset of severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. {ECO:0000269 PubMed:19085932, ECO:0000269 PubMed:21361913}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for BAG3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BAG3: view

No data available for Genatlas for BAG3 Gene

Publications for BAG3 Gene

  1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S. … Reed J.C. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. (PMID: 21459883) Villard E. … Cambien F. (Eur. Heart J. 2011) 3 4 46 64
  3. Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. (PMID: 10597216) Lee J.H. … Tsujimoto Y. (Oncogene 1999) 3 4 22 64
  4. BAG3-related myofibrillar myopathy in a Chinese family. (PMID: 21361913) Lee H. … Mak C. (Clin. Genet. 2012) 3 4 64
  5. Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy. (PMID: 22366786) Sarparanta J. … Udd B. (Nat. Genet. 2012) 3 4 64

Products for BAG3 Gene

Sources for BAG3 Gene

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