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BAG3 Gene

protein-coding   GIFtS: 63
GCID: GC10P121400

BCL2-Associated Athanogene 3

  See BAG3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BCL2-Associated Athanogene 31 2     MFM62 5
Bcl-2-Binding Protein Bis2 3     CAIR-12
Docking Protein CAIR-12 3     BAG Family Molecular Chaperone Regulator 32
BAG-32 3     BCL2-Binding Athanogene 32
BIS2 3     Bcl-2-Associated Athanogene 33

External Ids:    HGNC: 9391   Entrez Gene: 95312   Ensembl: ENSG000001519297   OMIM: 6038835   UniProtKB: O958173   

Export aliases for BAG3 gene to outside databases

Previous GC identifers: GC10P120329 GC10P120654 GC10P121542 GC10P121075 GC10P115040


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BAG3 Gene:
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the
BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their
N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG
domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70
ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of
Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. (provided by RefSeq, Jul 2008)

GeneCards Summary for BAG3 Gene:
BAG3 (BCL2-associated athanogene 3) is a protein-coding gene. Diseases associated with BAG3 include cardiomyopathy, dilated, 1hh, and myopathy, myofibrillar, 6. GO annotations related to this gene include protein complex binding and chaperone binding. An important paralog of this gene is BAG4.

UniProtKB/Swiss-Prot: BAG3_HUMAN, O95817
Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic
activity

Gene Wiki entry for BAG3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BAG3 gene promoter:
         GR   c-Fos   AP-1   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): BAG3 promoter sequence
   Search Chromatin IP Primers for BAG3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BAG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.2-q26.2   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q25.2-q26.2

BAG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAG3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P121400:  view genomic region     (about GC identifiers)

Start:
121,410,882 bp from pter      End:
121,437,331 bp from pter
Size:
26,450 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BAG3_HUMAN, O95817 (See protein sequence)
Recommended Name: BAG family molecular chaperone regulator 3  
Size: 575 amino acids; 61595 Da
Subunit: Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to Bcl-2 and PLC-gamma. Interacts with DNAJB6
Secondary accessions: A8K5L8 Q3B763 Q9NT20 Q9P120

Explore the universe of human proteins at neXtProt for BAG3: NX_O95817

Explore proteomics data for BAG3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys450
  • Modification sites at PhosphoSitePlus

  • See BAG3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004272.2  
    ENSEMBL proteins: 
     ENSP00000358081   ENSP00000410036  

    BAG3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for BAG3

     
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    antibodies-online proteins for BAG3 (15 products) 

     
    antibodies-online peptides for BAG3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003103 BAG_domain
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry O95817

    ProtoNet protein and cluster: O95817

    1 Blocks protein domain: IPB003103 Apoptosis regulator Bcl-2 protein

    UniProtKB/Swiss-Prot: BAG3_HUMAN, O95817
    Similarity: Contains 1 BAG domain
    Similarity: Contains 2 WW domains


    Find genes that share domains with BAG3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BAG3_HUMAN, O95817
    Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic
    activity

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19229298
    GO:0032403protein complex binding IEA--
    GO:0051087chaperone binding IEA--
         
    Find genes that share ontologies with BAG3           About GenesLikeMe


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Bag3):
     adipose tissue  cardiovascular system  cellular  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     muscle  no phenotypic analysis  other  respiratory system 

    Find genes that share phenotypes with BAG3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bag3tm1.1Jhl for BAG3

       genOway: Develop your customized and physiologically relevant rodent model for BAG3

    miRNA
    Products:
        
    miRTarBase miRNAs that target BAG3:
    hsa-mir-26b-5p (MIRT029481), hsa-mir-221-3p (MIRT046955)

    Block miRNA regulation of human, mouse, rat BAG3 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate BAG3:
    hsa-miR-548d-3p hsa-miR-891b hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidBAG3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAG3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane4
    nucleus2
    cytoskeleton1
    extracellular1
    golgi apparatus1
    vacuole1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA10597216
    GO:0005886plasma membrane IDA--
    GO:0030018Z disc IEA--
    GO:0043005neuron projection IEA--

    Find genes that share ontologies with BAG3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BAG3 About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis (WikiPathways)
    Apoptosis Modulation and Signaling0.38
    2Busulfan Pathway, Pharmacodynamics
    Busulfan Pathway, Pharmacodynamics


    1 BioSystems Pathway for BAG3
        Apoptosis Modulation and Signaling

    1 PharmGKB Pathway for BAG3
        Busulfan Pathway, Pharmacodynamics

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BAG3: 
              Type I Interferon Response in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BAG3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BAG3 (O958171, 2, 3 ENSP000003580814) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232804P081072, 3, ENSP000003930874MINT-8141810 MINT-7264704 I2D: score=3 STRING: ENSP00000393087
    ENSG00000212866P081072, 3MINT-8141810 MINT-7264704 I2D: score=3 
    ENSG00000215328P081072, 3MINT-8141810 MINT-7264704 I2D: score=3 
    ENSG00000224501P081072, 3MINT-8141810 MINT-7264704 I2D: score=3 
    ENSG00000231555P081072, 3MINT-8141810 MINT-7264704 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding NAS9873016
    GO:0007420brain development IEA--
    GO:0008625extrinsic apoptotic signaling pathway via death domain receptors IDA10597216
    GO:0010664negative regulation of striated muscle cell apoptotic process IEA--
    GO:0021510spinal cord development IEA--

    Find genes that share ontologies with BAG3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BAG3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BAG3 gene: 
    NM_004281.3  

    Unigene Cluster for BAG3:

    BCL2-associated athanogene 3
    Hs.523309  [show with all ESTs]
    Unigene Representative Sequence: NM_004281
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369085(uc001lel.3 uc001lem.3) ENST00000450186
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate BAG3:
    hsa-miR-548d-3p hsa-miR-891b hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidBAG3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: BAG3 (NM_004281)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BAG3
      QuantiTect SYBR Green Assays in human, mouse, rat BAG3
      QuantiFast Probe-based Assays in human, mouse, rat BAG3

    Additional mRNA sequence: 

    AF071218.2 AF095193.2 AF127139.1 AK222800.1 AK291333.1 AK313026.1 AL137582.1 BC006418.1 
    BC014656.1 BC107786.1 

    10 DOTS entries:

    DT.218171  DT.100794105  DT.100794103  DT.95151661  DT.100794107  DT.100663675  DT.91646179  DT.92438542 
    DT.95151971  DT.99998637 

    Selected AceView cDNA sequences (see all 297):

    BQ427693 BM835118 AA633832 BU727464 AA101636 CA426385 BC006418 AA312671 
    BU948575 BI822296 AI766969 BM550204 BM716292 CN484409 CF243159 AA865662 
    AI601139 BM675383 BM800951 BU733542 AA282538 CA843776 AI380810 BI518668 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for BAG3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:              -     -                                 
    SP2:              -     -                                 
    SP3:                                                      


    ECgene alternative splicing isoforms for BAG3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BAG3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTCAGAG
    BAG3 Expression
    About this image


    BAG3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
             Oviduct
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    BAG3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BAG3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523309
        Pathway & Disease-focused RT2 Profiler PCR Arrays including BAG3: 
              Type I Interferon Response in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BAG3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bag31 , 5 BCL2-associated athanogene 31, 5 85.29(n)1
    84.76(a)1
      7 (70.26 cM)5
    298101  NM_013863.51  NP_038891.41 
     1285235835 
    chicken
    (Gallus gallus)
    Aves BAG31 BCL2-associated athanogene 3 65.31(n)
    60.59(a)
      423931  XM_001233434.2  XP_001233435.2 
    lizard
    (Anolis carolinensis)
    Reptilia BAG36
    BCL2-associated athanogene 3
    49(a)
    1 ↔ 1
    3(66296469-66324550)
    African clawed frog
    (Xenopus laevis)
    Amphibia bag3-A2 BCL2-associated athanogene 3 74.46(n)    BC043807.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bag31 BCL2-associated athanogene 3 52.38(n)
    46.87(a)
      445139  NM_001003533.2  NP_001003533.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta stv6
    starvin
    13(a)
    1 → many
    3L(13470641-13476615)


    ENSEMBL Gene Tree for BAG3 (if available)
    TreeFam Gene Tree for BAG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BAG3 gene
    BAG42  BAG52  

    Find genes that share paralogs with BAG3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for BAG3
    PGOHUM00000238940


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BAG3 (see all 824)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219183121,2,,4
    CMyopathy, myofibrillar, 6 (MFM6)4 pathogenic1121789827(+) CATTCC/TGGTGA 2 P L mis10--------
    VAR_0667864
    Cardiomyopathy, dilated 1HH (CMD1HH)4--see VAR_0667862 L P mis40--------
    VAR_0667854
    Cardiomyopathy, dilated 1HH (CMD1HH)4--see VAR_0667852 E K mis40--------
    VAR_0667874
    Cardiomyopathy, dilated 1HH (CMD1HH)4--see VAR_0667872 V M mis40--------
    VAR_0654794
    Cardiomyopathy, dilated 1HH (CMD1HH)4--see VAR_0654792 R W mis40--------
    VAR_0667814
    Cardiomyopathy, dilated 1HH (CMD1HH)4--see VAR_0667812 R W mis40--------
    VAR_0654804
    Cardiomyopathy, dilated 1HH (CMD1HH)4--see VAR_0654802 R H mis40--------
    rs27364231,2
    C,A,H--115051145(+) TTTTTT/GTTTTT 1 -- int13Minor allele frequency- G:0.00NA WA 6
    rs1507852961,2
    C--115051145(+) TTTTT-/GTTTTT 1 -- int10--------
    rs343726341,2
    C--115054014(+) TTGTT-/G/TTG 
            
    TGTGT
    2 -- int1 cds10--------

    HapMap Linkage Disequilibrium report for BAG3 (121410882 - 121437331 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BAG3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522347CNV Loss19592680
    nsv825585CNV Gain20364138

    Human Gene Mutation Database (HGMD): BAG3
    Locus Specific Mutation Databases (LSDB): BAG3

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603883   
    OMIM disorders: 612954  613881  
    UniProtKB/Swiss-Prot: BAG3_HUMAN, O95817
  • Myopathy, myofibrillar, 6 (MFM6) [MIM:612954]: A neuromuscular disorder that results in early-onset,
    severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency
    during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display
    structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or
    larger hyaline masses, or amorphous material. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881]: A disorder characterized by ventricular dilation and
    impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of
    premature death. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 8 diseases for BAG3:    
    About MalaCards
    cardiomyopathy, dilated, 1hh    myopathy, myofibrillar, 6    bag3-related dilated cardiomyopathy    bag3-related myofibrillar myopathy
    giant axonal neuropathy    myofibrillar myopathy    cardiomyopathy, dilated, 1w    axonal neuropathy


    Find genes that share disorders with BAG3           About GenesLikeMe

    5 Novoseek inferred disease relationships for BAG3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 33.3 1 17493862 (1)
    leukemia 13.4 2 17493862 (1), 17164298 (1)
    cancer 7.8 5 17996194 (2), 19179333 (1), 17493862 (1), 11513873 (1)
    tumors 4.74 4 17164298 (2), 11513873 (1), 17996194 (1)
    necrosis 0 1 11513873 (1)

    GeneTests: BAG3
    GeneReviews: BAG3
    Genetic Association Database (GAD): BAG3
    Human Genome Epidemiology (HuGE) Navigator: BAG3 (9 documents)

    Export disorders for BAG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BAG3 gene, integrated from 10 sources (see all 138):
    (articles sorted by number of sources associating them with BAG3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PubMed id 9873016)1, 2, 3, 9 Takayama S.... Reed J.C. (J. Biol. Chem. 1999)
    2. A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. (PubMed id 21459883)1, 2, 4 Villard E.... Cambien F. (Eur. Heart J. 2011)
    3. Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. (PubMed id 10597216)1, 2, 9 Lee J.H....Tsujimoto Y. (Oncogene 1999)
    4. BAG3-related myofibrillar myopathy in a Chinese family. (PubMed id 21361913)1, 2 Lee H....Mak C. (Clin. Genet. 2012)
    5. Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy. (PubMed id 21353195)1, 2 Norton N.... Hershberger R.E. (Am. J. Hum. Genet. 2011)
    6. Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes. (PubMed id 21898660)1, 2 Arimura T.... Kimura A. (Hum. Mutat. 2011)
    7. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PubMed id 19850283)1, 4 Ikeda M....Iwata N. (Biol. Psychiatry 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9531 HGNC: 939 AceView: BAG3 Ensembl:ENSG00000151929 euGenes: HUgn9531
    ECgene: BAG3 H-InvDB: BAG3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BAG3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BAG3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BAG3 gene:
    Search GeneIP for patents involving BAG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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