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Aliases & Descriptions for BAG3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BAG-3 2, 3 | | BIS 2, 3 | | CAIR-1 2 | | MGC104307 2 | | OTTHUMP00000020599 2 |
| | | Descriptions |
|---|
| BAG-family molecular chaperone regulator-3 2 | | BCL2-associated athanogene 3 2 | | BCL2-binding athanogene 3 2 | | Bcl-2-associated athanogene 3 3 | | Bcl-2-binding protein 2 | | Bcl-2-binding protein Bis 3 | | Docking protein CAIR-1 2, 3 |
|
| | Search outside databases for aliases for BAG3 genePrevious GC identifers: GC10P120329 GC10P120654 GC10P121542 GC10P121075 |
Summaries for BAG3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for BAG3: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq] UniProtKB/Swiss-Prot: BAG3_HUMAN, O95817Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activityGene Wiki entry for BAG3 |
Genomic Location for BAG3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the BAG3 gene 
Entrez Gene cytogenetic band: 10q25.2-q26.2 Ensembl cytogenetic band: 10q26.11 HGNC cytogenetic band: 10q25.2-q26.2BAG3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P121400:
(about GC identifiers)
Start:
|
121,400,872 bp from pter |
End:
|
121,427,321 bp from pter |
Size:
|
26,450 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_030059.12
| Proteins for BAG3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: BAG3_HUMAN, O95817 (See
protein sequence)Recommended Name: BAG family molecular chaperone regulator 3 Size: 575 amino acids; 61595 Da
Subunit: Binds to the ATPase domain of HSP70/HSC chaperones. Binds to Bcl-2 and PLC-gamma
Secondary accessions: A8K5L8 Q3B763 Q9NT20 Q9P120Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004272.2
ENSEMBL proteins: ENSP00000358081
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for BAG3: Assays for BAG3: | Protein
Domains/ Families for BAG3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O95817
ProtoNet protein and cluster: O95817 1 Blocks protein family: IPB003103 Apoptosis regulator Bcl-2 protein
UniProtKB/Swiss-Prot: BAG3_HUMAN, O95817Similarity: Contains 1 BAG domainSimilarity: Contains 2 WW domains | Gene Function for BAG3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004281
Applied Biosystems Silencer® siRNAs for BAG3
Sigma-Aldrich siRNA for BAG3  Sigma-Aldrich shRNA Panels and shRNA for BAG3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004281                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004281                                  untagged cDNA clones in CMV expression vector (see all 2): NM_004281 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004281
UniProtKB/Swiss-Prot: BAG3_HUMAN, O95817Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity11 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Bag3):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- | About this table | Pathways & Interactions for BAG3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for BAG3 
5/7 Interacting proteins for BAG3 (ENSP000003580813) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for BAG3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for BAG3
|
Transcripts for BAG3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004281
Sigma-Aldrich siRNA for BAG3  Sigma-Aldrich shRNA Panels and shRNA for BAG3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004281 REFSEQ mRNAs for BAG3 gene: NM_004281.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004281               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004281                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004281                                  untagged cDNA clones in CMV expression vector (see all 2): NM_004281  Additional cDNA sequence: AF071218.2 AF095193.2 AF127139.1 AK222800.1 AK291333.1 AK313026.1 AL137582.1 BC006418.1 BC014656.1 BC107786.1 10 DOTS entries: DT.218171 DT.100794105 DT.100794103 DT.95151661 DT.100794107 DT.95151971 DT.100663675 DT.91646179 DT.92438542 DT.99998637 24/297 AceView cDNA sequences (see all 297
):BQ427693 BE409341 BU727464 CF243159 BU948817 CD557530 BI518668 BM835118 BF593187 BU948575 BI523980 AA280559 AI601139 BC006418 BM716292 AL137582 BM557325 CA843776 BU733542 AA034925 AA432265 AA282538 BU621949 AA865662
highest scoring ESTs for BAG3:H10530 AA034933 AA040866 AA043135 AA101635 AA101636 AA121931 AA121949 AA150669 AA150793 Unigene Cluster for BAG3: BCL2-associated athanogene 3 Hs.523309 [show with all ESTs]Unigene Representative Sequence: NM_004281
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for BAG3
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | |
| SP1: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for BAG3
1 Ensembl transcript including schematic representation: ENST00000369085
|
Expression for BAG3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| BAG3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for BAG3
1 / 2 / 3 3 probe-sets matching BAG3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CATTTCAGAG
SOURCE GeneReport for Unigene cluster: Hs.523309
|
Orthologs for BAG3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BAG3 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for BAG3
ENSEMBL Gene Tree for BAG3 | Paralogs for BAG3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for BAG3 gene
- BAG42 BAG52
|
SNPs/Variants for BAG3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for BAG3 (up to first 250kb)
|
Disorders & Mutations for BAG3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603883
5 Novoseek disease relationships for BAG3 gene
About this table
Human Gene Mutation Database: BAG3
|
Medical News for BAG3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for BAG3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/58 PubMed articles for BAG3 gene (see all 58
):- An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PubMed id 9873016)1, 2, 3, 4 Takayama S.... Reed J.C. (1999)
- Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. (PubMed id 10597216)1, 3, 4 Lee J.H....Tsujimoto Y. (1999)
- HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy. (PubMed id 18094623)2, 3 Carra S....Landry J. (2008)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)3, 4 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)3, 4 Tao W.A.... Aebersold R. (2005)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)3, 4 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)3, 4 Beausoleil S.A....Gygi S.P. (2004)
- CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70. (PubMed id 10980614)3, 4 Doong H.... Kohn E. (2000)
|
Search for BAG3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing BAG3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing BAG3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BAG3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for BAG3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for BAG3:

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