Aliases for BAG3 Gene
Aliases for BAG3 Gene
External Ids for BAG3 Gene
- HGNC: 939
- Entrez Gene: 9531
- Ensembl: ENSG00000151929
- OMIM: 603883
- UniProtKB: O95817
Previous GeneCards Identifiers for BAG3 Gene
- GC10P120329
- GC10P120654
- GC10P121542
- GC10P121075
- GC10P121400
- GC10P115040
Summaries for BAG3 Gene
-
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
GeneCards Summary for BAG3 Gene
BAG3 (BCL2 Associated Athanogene 3) is a Protein Coding gene. Diseases associated with BAG3 include Myopathy, Myofibrillar, 6 and Cardiomyopathy, Dilated, 1Hh. Among its related pathways are Cellular response to heat stress and Cellular Senescence. GO annotations related to this gene include protein complex binding and chaperone binding. An important paralog of this gene is BAG4.
UniProtKB/Swiss-Prot for BAG3 Gene
-
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG3 Gene
Genomics for BAG3 Gene
Regulatory Elements for BAG3 Gene
Enhancers for BAG3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH10G119686 | 1.6 | Ensembl ENCODE dbSUPER | 23.4 | +36.6 | 36571 | 3.8 | HDGF PKNOX1 FOXA2 ARID4B FEZF1 ZNF2 YY1 ZNF766 ZNF143 ZNF207 | BAG3 GRK5-IT1 MCMBP TXNP1 INPP5F |
| GH10G119650 | 2 | FANTOM5 Ensembl ENCODE dbSUPER | 18.3 | +4.3 | 4285 | 10.1 | HDGF PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 | SEC23IP BAG3 INPP5F TIAL1 MCMBP PHACTR2P1 GRK5 TXNP1 |
| GH10G119665 | 1.5 | Ensembl ENCODE dbSUPER | 14.9 | +17.3 | 17315 | 6.4 | PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF121 ZNF766 GLIS2 | BAG3 PHACTR2P1 INPP5F TXNP1 |
| GH10G119618 | 0.9 | Ensembl ENCODE | 17.5 | -31.5 | -31531 | 2.7 | CTCF MAZ ZSCAN4 HLF CEBPB REST ZSCAN21 NFIC JUND GATA3 | INPP5F BAG3 TIAL1 RAD1P1 GC10P119612 |
| GH10G119663 | 1.3 | Ensembl ENCODE dbSUPER | 10.7 | +12.7 | 12711 | 2.0 | ZSCAN4 MAX FOSL1 E2F1 CTBP1 GATA3 ZNF766 ARID3A FOS ZNF600 | BAG3 TXNP1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around BAG3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the BAG3 gene promoter:
Regulatory Element Products
Genomic Location for BAG3 Gene
- Chromosome:
- 10
- Start:
- 119,651,347 bp from pter
- End:
- 119,677,819 bp from pter
- Size:
- 26,473 bases
- Orientation:
- Plus strand
Genomic View for BAG3 Gene
Genes around BAG3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.11 by Ensembl
- 10q26.11 by Entrez Gene
- 10q26.11 by HGNC
BAG3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BAG3 Gene
Proteins for BAG3 Gene
-
Protein details for BAG3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95817-BAG3_HUMAN
- Recommended name:
- BAG family molecular chaperone regulator 3
- Protein Accession:
- O95817
- A8K5L8
- Q3B763
- Q9NT20
- Q9P120
Protein attributes for BAG3 Gene
- Size:
- 575 amino acids
- Molecular mass:
- 61595 Da
- Quaternary structure:
-
- Binds to the ATPase domain of HSP70/HSC70 chaperones (PubMed:9873016). Interacts with BCL2 (PubMed:10597216). Interacts with phospholipase C-gamma proteins (PubMed:10980614). Interacts with DNAJB6 (PubMed:22366786). Interacts (via BAG domain) with HSF1; this interaction occurs in normal and heat-shocked cells promoting HSF1 nucleocytoplasmic shuttling (PubMed:26159920). Interacts with HSPA8 (via NBD) (PubMed:27474739, PubMed:24318877). Interacts with HSPA1A (via NBD) and HSPA1B (via NBD) (PubMed:24318877). Interacts (via WW domain 1) with SYNPO2 (via PPPY motif) (PubMed:23434281).
Protein Expression for BAG3 Gene
Post-translational modifications for BAG3 Gene
Other Protein References for BAG3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for BAG3
-
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Abcam proteins for BAG3
Assay Products
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No data available for DME Specific Peptides for BAG3 Gene
Domains & Families for BAG3 Gene
Gene Families for BAG3 Gene
Protein Domains for BAG3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for BAG3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for BAG3 Gene
Function for BAG3 Gene
Molecular function for BAG3 Gene
- UniProtKB/Swiss-Prot Function:
- Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000774 | adenyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0032403 | protein complex binding | IEA | -- |
| GO:0045296 | cadherin binding | IDA | 25468996 |
| GO:0051087 | chaperone binding | IEA | -- |
Phenotypes for BAG3 Gene
- MGI mutant phenotypes for BAG3:
-
inferred from 5 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- immune system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- endocrine/exocrine gland phenotype
- integument phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for BAG3:
Animal Models for BAG3 Gene
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ViGene Biosciences lentiviral particle packaged cDNA for BAG3 gene
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miRNA for BAG3 Gene
- miRTarBase miRNAs that target BAG3
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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Horizon Cell Lines for BAG3
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BAG3 Gene
Localization for BAG3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BAG3 Gene
- Nucleus. Cytoplasm. Note=Colocalizes with HSF1 to the nucleus upon heat stress (PubMed:26159920). {ECO:0000269 PubMed:26159920}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 2 |
| extracellular | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 26159920 |
| GO:0005737 | cytoplasm | IEA,IDA | 26159920 |
| GO:0005829 | cytosol | TAS,IDA | -- |
| GO:0005886 | plasma membrane | IDA | -- |
| GO:0030018 | Z disc | IEA | -- |
Pathways & Interactions for BAG3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular response to heat stress | ||
| 2 | Busulfan Pathway, Pharmacodynamics | ||
| 3 | Cellular Senescence | ||
| 4 | Apoptosis Modulation and Signaling | ||
Pathways by source for BAG3 Gene
1 BioSystems pathway for BAG3 Gene
3 Reactome pathways for BAG3 Gene
1 PharmGKB pathway for BAG3 Gene
Interacting Proteins for BAG3 Gene
Selected Interacting proteins:
ENSP00000358081
O95817-BAG3_HUMAN
for BAG3 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006457 | protein folding | NAS | 9873016 |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007420 | brain development | IEA | -- |
| GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | IDA | 10597216 |
| GO:0010664 | negative regulation of striated muscle cell apoptotic process | IEA | -- |
Transcripts for BAG3 Gene
mRNA/cDNA for BAG3 Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (297) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for BAG3 Gene
CRISPR Products
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OriGene CRISPR knockouts for BAG3
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Santa Cruz Biotechnology (SCBT) CRISPR for BAG3
- GenScript: Design CRISPR guide RNA sequences for BAG3
miRNA Products
- Search ViGene Biosciences for BAG3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for BAG3
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ViGene Biosciences ready-to-package AAV shRNAs for BAG3 gene
Clone Products
- Sino Biological Human cDNA Clone for BAG3
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- VectorBuilder custom plasmid, inducible vectors for BAG3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAG3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||
| SP2: | - | - | |||||||||||||||
| SP3: |
Expression for BAG3 Gene
mRNA differential expression in normal tissues according to GTEx for BAG3 Gene
This gene is overexpressed in Muscle - Skeletal (x8.1).
This gene is overexpressed in Bone (21.6) and Bone marrow stromal cell (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BAG3 Gene
NURSA nuclear receptor signaling pathways regulating expression of BAG3 Gene:
BAG3SOURCE GeneReport for Unigene cluster for BAG3 Gene:
Hs.523309Evidence on tissue expression from TISSUES for BAG3 Gene
- Nervous system(4.8)
- Liver(4.3)
- Lung(4.3)
- Muscle(3.5)
- Heart(2.7)
Phenotype-based relationships between genes and organs from Gene ORGANizer for BAG3 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- nervous
- respiratory
- skeletal muscle
- skeleton
Organs:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- face
- head
- larynx
- mouth
- neck
- nose
- pharynx
- vocal cord
Thorax:
- diaphragm
- heart
- heart valve
- lung
- rib
- rib cage
Pelvis:
- pelvis
Limb:
- foot
- knee
- lower limb
- upper limb
General:
- blood
- blood vessel
- coagulation system
- peripheral nerve
- peripheral nervous system
- red blood cell
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for BAG3
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OriGene qPCR primer pairs and template standards for BAG3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BAG3 Gene
Orthologs for BAG3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BAG3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bag3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Bag3 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | BAG3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | BAG3 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | BAG3 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | BAG3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BAG3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | BAG3 35 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | bag3-A 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | bag3 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | stv 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5020 35 |
|
OneToMany |
- Species where no ortholog for BAG3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for BAG3 Gene
Variants for BAG3 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs121918312 | Pathogenic, Myopathy, myofibrillar, 6 (MFM6) [MIM:612954] | 119,672,373(+) | CATTC(A/C/T)GGTGA | reference, missense | |
| rs387906874 | Pathogenic, Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881] | 119,669,881(+) | CTTCC(C/T)GGGAG | reference, missense | |
| rs387906876 | Pathogenic, Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881] | 119,676,984(+) | TGTGC(A/G)TCAGG | reference, missense | |
| rs397514506 | Pathogenic, Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881] | 119,672,399(+) | TTACC(C/T)GGCCA | reference, missense | |
| rs397514507 | Pathogenic, Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881] | 119,676,939(+) | AGAGC(C/T)GCTGG | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3624708 | CNV | loss | 21293372 |
| esv3891891 | CNV | gain | 25118596 |
| nsv1045668 | CNV | gain | 25217958 |
| nsv522347 | CNV | loss | 19592680 |
| nsv825585 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.63;
89.10% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for BAG3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG3 Gene
Disorders for BAG3 Gene
(10) MalaCards diseases for BAG3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myopathy, myofibrillar, 6 |
|
|
| cardiomyopathy, dilated, 1hh |
|
|
| bag3-related dilated cardiomyopathy |
|
|
| dilated cardiomyopathy |
|
|
| familial isolated dilated cardiomyopathy |
|
|
Search BAG3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
BAG3_HUMAN- Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269 PubMed:21353195, ECO:0000269 PubMed:21459883, ECO:0000269 PubMed:21898660}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Myopathy, myofibrillar, 6 (MFM6) [MIM:612954]: A form of myofibrillar myopathy, a group of chronic neuromuscular disorders characterized at ultrastructural level by disintegration of the sarcomeric Z disc and myofibrils, and replacement of the normal myofibrillar markings by small dense granules, or larger hyaline masses, or amorphous material. MFM6 is characterized by early-onset of severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. {ECO:0000269 PubMed:19085932, ECO:0000269 PubMed:21361913, ECO:0000269 PubMed:21898660}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for BAG3
No data available for Genatlas for BAG3 Gene
Publications for BAG3 Gene
- An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S. … Reed J.C. (J. Biol. Chem. 1999) 2 3 4 22 64
- A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. (PMID: 21459883) Villard E. … Cambien F. (Eur. Heart J. 2011) 3 4 46 64
- Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. (PMID: 10597216) Lee J.H. … Tsujimoto Y. (Oncogene 1999) 3 4 22 64
- BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress. (PMID: 26159920) Jin Y.H. … Kim S.A. (Biochem. Biophys. Res. Commun. 2015) 3 4 64
- Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PMID: 24318877) Rauch J.N. … Gestwicki J.E. (J. Biol. Chem. 2014) 3 4 64
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- antibodies-online Antibodies for BAG3: See all 91
- antibodies-online Kits for BAG3: See all 11
- antibodies-online Proteins for BAG3: See all 17
- Search antibodies-online for peptides
- GeneTex BAG3 antibody for BAG3
- Search GeneTex for Proteins for BAG3
- ViGene Biosciences adenoviral particle packaged cDNA for BAG3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for BAG3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for BAG3 gene
- Search ViGene Biosciences for BAG3
- Santa Cruz Biotechnology (SCBT) Antibodies for BAG3
- Search Santa Cruz Biotechnology (SCBT) for BAG3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BAG3
- Horizon Cell Lines for BAG3
- Cyagen custom Knockout/knockin (KOKI) mouse models for BAG3
- VectorBuilder custom plasmid, inducible vectors for BAG3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAG3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for BAG3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer