Aliases for BAG3 Gene
External Ids for BAG3 Gene
Previous GeneCards Identifiers for BAG3 Gene
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
GeneCards Summary for BAG3 Gene
BAG3 (BCL2 Associated Athanogene 3) is a Protein Coding gene. Diseases associated with BAG3 include Myopathy, Myofibrillar, 6 and Cardiomyopathy, Dilated, 1Hh. Among its related pathways are Cellular response to heat stress and Apoptosis Modulation and Signaling. GO annotations related to this gene include protein complex binding and chaperone binding. An important paralog of this gene is BAG5.
UniProtKB/Swiss-Prot for BAG3 Gene
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.