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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BAG2 Gene

protein-coding   GIFtS: 61
GCID: GC06P057084

BCL2-Associated Athanogene 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BCL2-Associated Athanogene 21 2     BAG-Family Molecular Chaperone Regulator-22
Bcl-2-Associated Athanogene 22 3     dJ417I1.22
BAG-22 3     DJ417I1.2 (BAG-Family Molecular Chaperone Regulator 2)2
BAG Family Molecular Chaperone Regulator 22     

External Ids:    HGNC: 9381   Entrez Gene: 95322   Ensembl: ENSG000001122087   OMIM: 6038825   UniProtKB: O958163   

Export aliases for BAG2 gene to outside databases

Previous GC identifers: GC06P057039 GC06P057083 GC06P057145 GC06P056871


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BAG2 Gene:
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the
BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their
N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3
interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high
affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. (provided
by RefSeq, Jul 2008)

GeneCards Summary for BAG2 Gene: 
BAG2 (BCL2-associated athanogene 2) is a protein-coding gene. Diseases associated with BAG2 include thyroiditis, and among its related super-pathways are Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot: BAG2_HUMAN, O95816
Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release

Gene Wiki entry for BAG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BAG2 gene promoter:
         AML1a   Lmo2   HNF-4alpha2   HNF-4alpha1   AREB6   POU2F1   POU2F1a   POU2F1b   c-Myb   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBAG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BAG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1-p11.2   Ensembl cytogenetic band:  6p11.2   HGNC cytogenetic band: 6p12.3-p11.2

BAG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAG2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P057084:  view genomic region     (about GC identifiers)

Start:
57,037,104 bp from pter      End:
57,054,631 bp from pter
Size:
17,528 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BAG2_HUMAN, O95816 (See protein sequence)
Recommended Name: BAG family molecular chaperone regulator 2  
Size: 211 amino acids; 23772 Da
Subunit: Binds to the ATPase domain of HSP/HSC70 chaperones
Secondary accessions: Q08AS9 Q6FID0

Explore the universe of human proteins at neXtProt for BAG2: NX_O95816

Explore proteomics data for BAG2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95816

  • BAG2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BAG2 Protein Expression
    REFSEQ proteins: NP_004273.1  
    ENSEMBL proteins: 
     ENSP00000359727   ENSP00000441795  

    Human Recombinant Protein Products for BAG2: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003103 BAG_domain

    Graphical View of Domain Structure for InterPro Entry O95816

    ProtoNet protein and cluster: O95816

    1 Blocks protein domain: IPB003103 Apoptosis regulator Bcl-2 protein

    UniProtKB/Swiss-Prot: BAG2_HUMAN, O95816
    Similarity: Contains 1 BAG domain


    BAG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BAG2_HUMAN, O95816
    Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release

         Genatlas biochemistry entry for BAG2:
    BCL2-associated athanogene 2 (antiapoptotic). Negative regulator of Hsp70 chaperone activity

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18457437
    GO:0051087chaperone binding IEA--
         
    BAG2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for BAG2:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BAG2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of degradation of wt-CFTR
    Regulation of degradation of wt-CFTR0.59
    Regulation of degradation of deltaF508 CFTR in CF0.59
    2Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for BAG2
        Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR



    1         Kegg Pathway  (Kegg details for BAG2):
        Protein processing in endoplasmic reticulum


    BAG2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BAG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/146 Interacting proteins for BAG2 (O958162, 3 ENSP000003597274) via UniProtKB, MINT, STRING, and/or I2D (see all 146)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232804P081072, 3, ENSP000003930874MINT-6735120 I2D: score=2 STRING: ENSP00000393087
    ENSG00000212866P081072, 3MINT-6735120 I2D: score=2 
    ENSG00000215328P081072, 3MINT-6735120 I2D: score=2 
    ENSG00000224501P081072, 3MINT-6735120 I2D: score=2 
    ENSG00000231555P081072, 3MINT-6735120 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS9873016
    GO:0019538protein metabolic process IDA9873015

    BAG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BAG2

    Search CenterWatch for drugs/clinical trials and news about BAG2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BAG2 gene: 
    NM_004282.3  

    Unigene Cluster for BAG2:

    BCL2-associated athanogene 2
    Hs.745046  [show with all ESTs]
    Unigene Representative Sequence: NM_004282
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370693(uc003pdr.3 uc011dxo.2) ENST00000545080
    miRNA
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    hsa-miR-140-5p hsa-miR-27a hsa-miR-101* hsa-miR-128 hsa-miR-548e hsa-miR-3681* hsa-miR-548o hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidBAG2 3' UTR sequence
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    Additional mRNA sequence: 

    AF095192.1 AK001015.1 AK023735.1 AK301934.1 AL050287.1 BC125039.1 CR533496.1 

    8 DOTS entries:

    DT.216070  DT.75100891  DT.92435211  DT.100763122  DT.91688433  DT.92435204  DT.92435206  DT.91752933 

    24/211 AceView cDNA sequences (see all 211):

    AA488507 CA442969 AI654091 CD742992 AA938204 AI097375 AL050287 CR606486 
    BM970449 AI239442 AA993960 AI338049 AW237181 BM793079 AA134563 AL546760 
    AI372939 BI756070 AW292035 AI018267 AI628654 AW513650 CR612315 CD519662 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BAG2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c
    SP1:                                -                                             
    SP2:              -     -     -     -     -                                       
    SP3:              -     -     -     -                                             
    SP4:                                      -                                       
    SP5:                                -     -                                       


    ECgene alternative splicing isoforms for BAG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BAG2 expression in normal human tissues (normalized intensities)      BAG2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATCACGCA
    BAG2 Expression
    About this image


    BAG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Uterus (Reproductive System)

    See BAG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BAG2

    SOURCE GeneReport for Unigene cluster: Hs.745046
        SABiosciences Expression via Pathway-Focused PCR Array including BAG2: 
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BAG2 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bag21 , 5 BCL2-associated athanogene 21, 5 85.56(n)1
    93.81(a)1
      1 (12.81 cM)5
    2135391  NM_145392.21  NP_663367.11 
     337454845 
    chicken
    (Gallus gallus)
    Aves BAG21 BCL2-associated athanogene 2 75.73(n)
    78.46(a)
      421880  XM_419897.3  XP_419897.3 
    lizard
    (Anolis carolinensis)
    Reptilia BAG26
    Uncharacterized protein
    67(a)
    1 ↔ 1
    1(162955644-162967463)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.173232 Xenopus laevis transcribed sequence with weak similarity more 71.31(n)    BJ080418.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc641952 similar to Bcl2-associated athanogene 2 72.26(n)   393975  BC053303.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79451 CG7945 46.35(n)
    39.64(a)
      39679  NM_140516.2  NP_648773.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-231 Protein UNC-23 47.45(n)
    40.59(a)
      179272  NM_001028840.2  NP_001024011.1 


    ENSEMBL Gene Tree for BAG2 (if available)
    TreeFam Gene Tree for BAG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/221 SNPs in BAG2 are shown (see all 221)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492789051,2
    --57035902(+) CTAGGA/TTAAGA 1 -- us2k10--------
    rs1860639471,2
    --57035912(+) AGAGAA/GAAAGA 1 -- us2k10--------
    rs1912876151,2
    --57035955(+) TTTCAA/GACCAC 1 -- us2k10--------
    rs1812308861,2
    --57036441(+) TCTATC/TGCCCA 1 -- us2k10--------
    rs796377621,2
    F--57036608(+) TCGAGG/ACTGCA 1 -- us2k12Minor allele frequency- A:0.06CSA WA 120
    rs1443233781,2
    C--57036880(+) CTTCTA/GTTTCA 1 -- us2k10--------
    rs1853190111,2
    --57037010(+) TTCGCG/TTGGGG 1 -- us2k10--------
    rs1905964771,2
    --57037017(+) GGGGGC/GAGTTG 1 -- us2k10--------
    rs1827288501,2
    --57037019(+) GGGGAA/GTTGGT 1 -- us2k10--------
    rs761197401,2
    C,F--57037488(+) GTCGGA/CGGCTT 1 -- ut511Minor allele frequency- C:0.09WA 118

    HapMap Linkage Disequilibrium report for BAG2 (57037104 - 57054631 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BAG2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv462949CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
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    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing BAG2
    DNA2.0 Custom Variant and Variant Library Synthesis for BAG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603882    OMIM disorders: --

    2 diseases for BAG2:    About MalaCards
    thyroiditis    

    1 disease from the University of Copenhagen DISEASES database for BAG2:
    Spindle cell hemangioma

    BAG2 for disorders           About GeneDecksing


    Export disorders for BAG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BAG2 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with BAG2)
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    1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PubMed id 9873016)1, 2, 3, 9 Takayama S.... Reed J.C. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    5. Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (2013)
    6. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    7. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    8. Identification of the hypoxia-inducible factor 2a nucl ear interactome in melanoma cells reveals master proteins involved in melanoma d evelopment. (PubMed id 23275444)1 Steunou A.L....Nieto L. (2013)
    9. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (2013)
    10. Proteomic analysis of the NOS2 interactome in human ai rway epithelial cells. (PubMed id 23438482)1 Foster M.W....Marshall H.E. (2013)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9532 HGNC: 938 AceView: BAG2 Ensembl:ENSG00000112208 euGenes: HUgn9532
    ECgene: BAG2 Kegg: 9532 H-InvDB: BAG2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BAG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BAG2 gene:
    Search GeneIP for patents involving BAG2

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