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BAG2 Gene

protein-coding   GIFtS: 57

GC06P057145
BCL2-associated athanogene 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
BAG-2 2, 3
KIAA0576 2
MGC149462 2
OTTHUMP00000016668 2
dJ417I1.2 2
Descriptions
BAG-family molecular chaperone regulator-2 2
BCL2-associated athanogene 2 2
Bcl-2-associated athanogene 2 3
dJ417I1.2 (BAG-family molecular chaperone regulator 2) 2
External Ids
HGNC: 9381
Entrez Gene: 95322
UniProtKB: O958163
Ensembl: ENSG000001122087
Search outside databases for aliases for BAG2 gene

Previous GC identifers: GC06P057039 GC06P057083 GC06P057084

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for BAG2:
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate
release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus
but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino
acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain
in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of
Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq]

UniProtKB/Swiss-Prot: BAG2_HUMAN, O95816
Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release

Gene Wiki entry for BAG2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BAG2 gene  

Entrez Gene cytogenetic band: 6p12.1-p11.2   Ensembl cytogenetic band:  6p12.1   HGNC cytogenetic band: 6p12.3-p11.2

BAG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P057145:     (about GC identifiers)

Start:
57,145,083 bp from pter
End:
57,157,694 bp from pter
Size:
12,612 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000006.10  NT_007592.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BAG2_HUMAN, O95816 (See protein sequence)
Recommended Name: BAG family molecular chaperone regulator 2  
Size: 211 amino acids; 23772 Da
Subunit: Binds to the ATPase domain of HSP70/HSC chaperones
Secondary accessions: Q08AS9 Q6FID0

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_004273.1  

    ENSEMBL proteins: 
    ENSP00000359727 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (BAG2)
    Human Recombinant Proteins from Abnova (BAG2)
                  OriGene Purified Recombinant Human Protein: BAG2 


    Antibodies for BAG2: 
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    Novus Biologicals Antibodies for BAG2

    Assays for BAG2: 
    Browse Invitrogen for biochemical assays
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    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR003103 Apoptosis_reg_Bcl-2_prot_BAG


       GeneDecks  BAG2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O95816

    ProtoNet protein and cluster: O95816

    1 Blocks protein family: IPB003103 Apoptosis regulator Bcl-2 protein

    UniProtKB/Swiss-Prot: BAG2_HUMAN, O95816
    Similarity: Contains 1 BAG domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BAG2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BAG2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004282

                  Applied Biosystems Silencer® siRNAs for BAG2

                  Sigma-Aldrich siRNA for BAG2  
                         Sigma-Aldrich shRNA for BAG2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004282
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004282
                                     untagged cDNA clone in CMV expression vector: NM_004282 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_004282

    UniProtKB/Swiss-Prot: BAG2_HUMAN, O95816
    Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release

    Genatlas biochemistry entry for BAG2:
    BCL2-associated athanogene 2 (antiapoptotic). Negative regulator of Hsp70 chaperone activity

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI17353931
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  BAG2 


    5/36 Interacting proteins for BAG2 (ENSP000003597273 O958161, 2) via UniProtKB, MINT, and/or STRING (see all 36 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA8P111422STRING (score=.996) MINT-6735120
    MLF2Q157731EBI-355275, EBI-1051875
    PSMC4P436861EBI-355275, EBI-743997
    BAG2O958162MINT-6735120
    ENSG00000204388P081072MINT-6735120
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457 protein folding TAS9873016
    GO:0006915 apoptosis IEA--
    GO:0019538 protein metabolic process IDA9873015
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for BAG2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BAG2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BAG2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004282

                  Sigma-Aldrich siRNA for BAG2  
                         Sigma-Aldrich shRNA for BAG2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004282  

    REFSEQ mRNAs for BAG2 gene: 

    NM_004282.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004282  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004282
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004282
                                     untagged cDNA clone in CMV expression vector: NM_004282 

    Additional cDNA sequence: 

    AF095192.1 AK001015.1 AK023735.1 AK301934.1 AL050287.1 BC125039.1 CR533496.1 CR606486.1 
    CR612315.1 CR621395.1 

    8 DOTS entries:

    DT.216070  DT.75100891  DT.92435211  DT.100763122  DT.91688433  DT.92435204  DT.92435206  DT.91752933 

    24/211 AceView cDNA sequences (see all 211 ):

    AA938204 AA993960 AI372939 BF222738 BM970449 AI376350 AI828270 BU753559 
    AL048064 CD742992 AA279359 CA442969 AA741485 AA436583 BU627661 CR612315 
    AW590290 BX369942 AA418744 BE780952 AW237181 CR621395 BX403369 AA253071 

    highest scoring ESTs for BAG2:

    AL050287 AA004642 AA113351 AA113433 AA134562 AA136041 AA253035 AA253071 AA256610 AA280336 

    Unigene Cluster for BAG2:

    BCL2-associated athanogene 2
    Hs.719303  [show with all ESTs]
    Unigene Representative Sequence: NM_004282


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BAG2

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c
    SP1:                                -                                             
    SP2:              -     -     -     -     -                                       
    SP3:              -     -     -     -                                             
    SP4:                                      -                                       
    SP5:                                -     -                                       

    About this scheme

    ECgene alternative splicing isoforms for BAG2

    1 Ensembl transcript including schematic representation:
    ENST00000370693  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    BAG2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for BAG2

    1 / 2 / 3

    3 probe-sets matching BAG2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    35291_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AL050287 1.00 1.00 1.00 1

    209406_at2, 3 U133-A 1 1.00 1.00 -- -- AF095192 0.80 1.00 0.91 1

    209406_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.719303

    Expression variation in blood from EXPOLDB for BAG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for BAG2 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    BAG21   -- BCL2-associated athanogene 2 94.31(n)
    97.63(a)
    610506  XM_848025.1  XP_853118.1 
    chimpanzee
    (Pan troglodytes)
    BAG21   -- BCL2-associated athanogene 2 100(n)
    100(a)
    462797  XM_518563.2  XP_518563.1 
    cow
    (Bos taurus)
    BAG21   -- BCL2-associated athanogene 2 84.2(n)
    95.26(a)
    506107  NM_001034264.1  NP_001029436.1 
    rat
    (Rattus norvegicus)
    Bag21   -- Bcl2-associated athanogene 2 83.05(n)
    90.86(a)
    690038  XM_001073000.1  XP_001073000.1 
    mouse
    (Mus musculus)
    Bag21, 5 15
    BCL2-associated athanogene 21, 5 85.56(n)1
    93.81(a)1
    2135391  NM_145392.21  NP_663367.11 
     AK0513525  AK0836005  (see all 13)
    About this table        Species with no ortholog for BAG2

    ENSEMBL Gene Tree for BAG2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/47 NCBI SNPs in BAG2 are shown (see all 47 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 45)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs37785151,2
    A,C,F,H57150668(-) CTAGTA/CCCCAG 1 -- int112Minor allele frequency- C:0.15EA NA EU WA 2452
    rs77499601,2
    A,C,F,H57153515(+) gcataC/Agccat 1 -- int14Minor allele frequency- A:0.11EU EA WA 416
    rs98857571,2
    A,C,F,H57156417(+) AGTTTC/TAGCTT 1 -- int18Minor allele frequency- N:0.00EU EA WA NA 624
    rs20392131,2
    A,C,F57151714(+) AAATGA/GAACCT 1 -- int13Minor allele frequency- G:0.01NA 142
    rs93705671,2
    C,F,H57146328(+) AATACA/CGTAGT 1 -- int17Minor allele frequency- C:0.08EU EA WA NA 558
    rs77569471,2
    A,H57149462(+) TTCGTC/TTGGCT 1 -- int14Minor allele frequency- T:0.00EU EA WA 416
    rs77501771,2
    A,H57153468(+) aaataG/Tgacca 1 -- int14Minor allele frequency- T:0.00EU EA WA 410
    rs77499701,2
    A,H57153547(+) TTGATC/TGCATC 1 -- int14Minor allele frequency- T:0.00EU EA WA 416
    rs77496311,2
    A,H57153257(+) catggC/Gataga 1 -- int14Minor allele frequency- G:0.00EU EA WA 406
    rs77500451,2
    A,H57153395(+) ttgatG/Tctagg 1 -- int14Minor allele frequency- T:0.00EU EA WA 414
    About this table

    HapMap Linkage Disequilibrium images for BAG2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 603882

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/18 PubMed articles for BAG2 gene (see all 18 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 9532 HGNC: 938 AceView: BAG2 Ensembl:ENSG00000112208 euGenes: HUgn9532
    ECgene: BAG2 H-InvDB: BAG2
    (According to HUGE)
    About This Section

    HUGE: KIAA0576
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for BAG2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for BAG2 Antibodies for BAG2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for BAG2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for BAG2

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