 |
 | Services
| |
 |
Aliases & Descriptions for BAG2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BAG-2 2, 3 | | KIAA0576 2 | | MGC149462 2 | | OTTHUMP00000016668 2 | | dJ417I1.2 2 |
| | | Descriptions |
|---|
| BAG-family molecular chaperone regulator-2 2 | | BCL2-associated athanogene 2 2 | | Bcl-2-associated athanogene 2 3 | | dJ417I1.2 (BAG-family molecular chaperone regulator 2) 2 |
|
| | Search outside databases for aliases for BAG2 genePrevious GC identifers: GC06P057039 GC06P057083 GC06P057084 |
Summaries for BAG2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for BAG2: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq] UniProtKB/Swiss-Prot: BAG2_HUMAN, O95816Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate releaseGene Wiki entry for BAG2 |
Genomic Location for BAG2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the BAG2 gene 
Entrez Gene cytogenetic band: 6p12.1-p11.2 Ensembl cytogenetic band: 6p12.1 HGNC cytogenetic band: 6p12.3-p11.2BAG2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P057145:
(about GC identifiers)
Start:
|
57,145,083 bp from pter |
End:
|
57,157,694 bp from pter |
Size:
|
12,612 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14
| Proteins for BAG2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: BAG2_HUMAN, O95816 (See
protein sequence)Recommended Name: BAG family molecular chaperone regulator 2 Size: 211 amino acids; 23772 Da
Subunit: Binds to the ATPase domain of HSP70/HSC chaperones
Secondary accessions: Q08AS9 Q6FID0Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004273.1
ENSEMBL proteins: ENSP00000359727
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: BAG2 
Antibodies for BAG2: Assays for BAG2: | Protein
Domains/ Families for BAG2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O95816
ProtoNet protein and cluster: O95816 1 Blocks protein family: IPB003103 Apoptosis regulator Bcl-2 protein
UniProtKB/Swiss-Prot: BAG2_HUMAN, O95816Similarity: Contains 1 BAG domain | Gene Function for BAG2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004282
Applied Biosystems Silencer® siRNAs for BAG2
Sigma-Aldrich siRNA for BAG2  Sigma-Aldrich shRNA for BAG2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004282                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004282                                  untagged cDNA clone in CMV expression vector: NM_004282 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004282
UniProtKB/Swiss-Prot: BAG2_HUMAN, O95816Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate releaseGenatlas biochemistry entry for BAG2:BCL2-associated athanogene 2 (antiapoptotic). Negative regulator of Hsp70 chaperone activity1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for BAG2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for BAG2 
5/36 Interacting proteins for BAG2 (ENSP000003597273 O958161, 2) via UniProtKB, MINT, and/or STRING (see all 36
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for BAG2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for BAG2
|
Transcripts for BAG2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004282
Sigma-Aldrich siRNA for BAG2  Sigma-Aldrich shRNA for BAG2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004282 REFSEQ mRNAs for BAG2 gene: NM_004282.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004282               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004282                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004282                                  untagged cDNA clone in CMV expression vector: NM_004282  Additional cDNA sequence: AF095192.1 AK001015.1 AK023735.1 AK301934.1 AL050287.1 BC125039.1 CR533496.1 CR606486.1 CR612315.1 CR621395.1 8 DOTS entries: DT.216070 DT.75100891 DT.92435211 DT.100763122 DT.91688433 DT.92435204 DT.92435206 DT.91752933 24/211 AceView cDNA sequences (see all 211
):AA938204 AA993960 AI372939 BF222738 BM970449 AI376350 AI828270 BU753559 AL048064 CD742992 AA279359 CA442969 AA741485 AA436583 BU627661 CR612315 AW590290 BX369942 AA418744 BE780952 AW237181 CR621395 BX403369 AA253071
highest scoring ESTs for BAG2:AL050287 AA004642 AA113351 AA113433 AA134562 AA136041 AA253035 AA253071 AA256610 AA280336 Unigene Cluster for BAG2: BCL2-associated athanogene 2 Hs.719303 [show with all ESTs]Unigene Representative Sequence: NM_004282
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for BAG2
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for BAG2
1 Ensembl transcript including schematic representation: ENST00000370693
|
Expression for BAG2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| BAG2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for BAG2
1 / 2 / 3 3 probe-sets matching BAG2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.719303
Expression variation in blood from EXPOLDB for BAG2 |
Orthologs for BAG2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BAG2 gene from 5/13 species (see all 13
)
About this table Species with no ortholog for BAG2
ENSEMBL Gene Tree for BAG2 | Paralogs for BAG2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for BAG2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for BAG2 (up to first 250kb)
|
Disorders & Mutations for BAG2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603882
|
Medical News for BAG2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for BAG2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/18 PubMed articles for BAG2 gene (see all 18
): |
Search for BAG2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing BAG2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing BAG2
(According to HUGE)
About This Section
| |
Specialized Databases showing BAG2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for BAG2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for BAG2:

 | |
 | | | | |
|
 |  |  |
| | Recombinant Proteins (BAG2) | | Antibodies (BAG2) |
| | | Search Tocris compounds for BAG2 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|