Aliases for BAG2 Gene
Aliases for BAG2 Gene
External Ids for BAG2 Gene
- HGNC: 938
- Entrez Gene: 9532
- Ensembl: ENSG00000112208
- OMIM: 603882
- UniProtKB: O95816
Previous GeneCards Identifiers for BAG2 Gene
- GC06P057039
- GC06P057083
- GC06P057084
- GC06P056871
Summaries for BAG2 Gene
-
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
GeneCards Summary for BAG2 Gene
BAG2 (BCL2 Associated Athanogene 2) is a Protein Coding gene. Diseases associated with BAG2 include Spindle Cell Hemangioma. Among its related pathways are Protein processing in endoplasmic reticulum and Cellular response to heat stress. GO annotations related to this gene include identical protein binding and chaperone binding.
UniProtKB/Swiss-Prot for BAG2 Gene
-
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG2 Gene
Genomics for BAG2 Gene
Regulatory Elements for BAG2 Gene
- Transcription factor binding sites by QIAGEN in the BAG2 gene promoter:
Regulatory Element Products
Genomic Location for BAG2 Gene
- Chromosome:
- 6
- Start:
- 57,172,306 bp from pter
- End:
- 57,189,833 bp from pter
- Size:
- 17,528 bases
- Orientation:
- Plus strand
Genomic View for BAG2 Gene
- Cytogenetic band:
-
- 6p12.1 by Ensembl
- 6p12.1 by Entrez Gene
- 6p12.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BAG2 Gene
Proteins for BAG2 Gene
-
Protein details for BAG2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95816-BAG2_HUMAN
- Recommended name:
- BAG family molecular chaperone regulator 2
- Protein Accession:
- O95816
- B4DXE2
- Q08AS9
- Q6FID0
Protein attributes for BAG2 Gene
- Size:
- 211 amino acids
- Molecular mass:
- 23772 Da
- Quaternary structure:
-
- Binds to the ATPase domain of HSP/HSC70 chaperones (PubMed:9873016). May interact with NWD1 (PubMed:24681825). Interacts with HSPA1A (via NBD), HSPA1B (via NBD) and HSPA8 (PubMed:24318877).
Protein Expression for BAG2 Gene
Post-translational modifications for BAG2 Gene
Other Protein References for BAG2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for BAG2
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- antibodies-online Antibodies for BAG2: See all 75
- GeneTex BAG2 antibody for BAG2
-
Santa Cruz Biotechnology (SCBT) Antibodies for BAG2
Protein Products
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- ProSpec Recombinant Proteins for BAG2
- antibodies-online Proteins for BAG2: See all 18
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- Search GeneTex for Proteins for BAG2
-
ProSci Proteins for BAG2
Assay Products
- antibodies-online Kits for BAG2: See all 3
No data available for DME Specific Peptides for BAG2 Gene
Domains & Families for BAG2 Gene
Gene Families for BAG2 Gene
Protein Domains for BAG2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for BAG2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for BAG2 Gene
Function for BAG2 Gene
Molecular function for BAG2 Gene
- GENATLAS Biochemistry:
- BCL2-associated athanogene 2 (antiapoptotic). Negative regulator of Hsp70 chaperone activity
- UniProtKB/Swiss-Prot Function:
- Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000774 | adenyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 18457437 |
| GO:0042802 | identical protein binding | IPI | 22365833 |
| GO:0051087 | chaperone binding | IEA | -- |
Phenotypes for BAG2 Gene
- GenomeRNAi human phenotypes for BAG2:
Animal Model Products
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-
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CRISPR Products
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miRNA for BAG2 Gene
- miRTarBase miRNAs that target BAG2
-
- hsa-mir-128-3p (MIRT021988)
- hsa-mir-181a-5p (MIRT025092)
- hsa-mir-93-5p (MIRT048797)
- hsa-mir-5004-3p (MIRT448979)
- hsa-mir-223-3p (MIRT448980)
- hsa-mir-4328 (MIRT448981)
- hsa-mir-5002-5p (MIRT448982)
- hsa-mir-5590-3p (MIRT448983)
- hsa-mir-142-5p (MIRT448984)
- hsa-mir-6507-3p (MIRT448985)
- hsa-mir-6514-3p (MIRT628692)
- hsa-mir-6847-3p (MIRT628693)
- hsa-mir-6811-3p (MIRT628694)
- hsa-mir-214-5p (MIRT628695)
- hsa-mir-486-5p (MIRT628696)
- hsa-mir-339-5p (MIRT628697)
- hsa-mir-4446-5p (MIRT722348)
- hsa-mir-4755-5p (MIRT722349)
- hsa-mir-5006-3p (MIRT722350)
- hsa-mir-6883-3p (MIRT722351)
- hsa-mir-27b-3p (MIRT722352)
- hsa-mir-27a-3p (MIRT722353)
- hsa-mir-513a-5p (MIRT722354)
- hsa-mir-627-3p (MIRT722355)
- hsa-mir-3681-3p (MIRT722356)
- hsa-mir-130b-5p (MIRT722357)
- hsa-mir-216a-3p (MIRT722358)
- hsa-mir-6750-3p (MIRT722359)
miRNA Products
- Search ViGene Biosciences for BAG2
Inhibitory RNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for BAG2
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BAG2 Gene
Localization for BAG2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for BAG2 Gene
Pathways & Interactions for BAG2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular response to heat stress | ||
| 2 | Regulation of degradation of deltaF508 CFTR in CF | ||
| 3 | Protein processing in endoplasmic reticulum | ||
| 4 | Cellular Senescence | ||
Pathways by source for BAG2 Gene
3 Reactome pathways for BAG2 Gene
1 KEGG pathway for BAG2 Gene
2 GeneGo (Thomson Reuters) pathways for BAG2 Gene
Interacting Proteins for BAG2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006457 | protein folding | TAS | 9873016 |
| GO:0019538 | protein metabolic process | IDA | 9873015 |
| GO:0050790 | regulation of catalytic activity | IEA | -- |
| GO:1900034 | regulation of cellular response to heat | TAS | -- |
Transcripts for BAG2 Gene
mRNA/cDNA for BAG2 Gene
- (4) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (211) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for BAG2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for BAG2
-
Santa Cruz Biotechnology (SCBT) CRISPR for BAG2
- GenScript: Design CRISPR guide RNA sequences for BAG2
miRNA Products
- Search ViGene Biosciences for BAG2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for BAG2
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-
ViGene Biosciences ready-to-package AAV shRNAs for BAG2 gene
Clone Products
- Sino Biological Human cDNA Clone for BAG2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for BAG2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAG2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||
| SP5: | - | - |
Expression for BAG2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Uterus (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for BAG2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BAG2 Gene
NURSA nuclear receptor signaling pathways regulating expression of BAG2 Gene:
BAG2SOURCE GeneReport for Unigene cluster for BAG2 Gene:
Hs.745046Evidence on tissue expression from TISSUES for BAG2 Gene
- Liver(4.2)
- Muscle(3)
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs for BAG2
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAG2 Gene
Orthologs for BAG2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BAG2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | BAG2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | BAG2 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | BAG2 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Bag2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bag2 34 |
|
||
| cow (Bos Taurus) |
Mammalia | BAG2 34 35 |
|
||
| chicken (Gallus gallus) |
Aves | BAG2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | BAG2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bag2 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.17323 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | bag2 34 35 |
|
||
| zgc64195 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.396 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010983 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7945 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | unc-23 34 35 |
|
- Species where no ortholog for BAG2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for BAG2 Gene
No data available for Paralogs for BAG2 Gene
Variants for BAG2 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000195032 | -- | 57,171,476(+) | TGTAT(C/T)CTCAG | intron-variant, upstream-variant-2KB | |
| rs1000513353 | -- | 57,175,297(+) | TTTCC(G/T)GGCTC | intron-variant | |
| rs1000700013 | -- | 57,171,825(+) | GTCGT(A/G)ATCGC | intron-variant, upstream-variant-2KB | |
| rs1000734649 | -- | 57,176,253(+) | AATGA(C/T)TTGTC | intron-variant | |
| rs1000804002 | -- | 57,178,014(+) | AGGGA(A/G)TTTTC | intron-variant |
Relevant External Links for BAG2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BAG2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG2 Gene
Disorders for BAG2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spindle cell hemangioma |
|
|
Relevant External Links for BAG2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- BAG2
No data available for UniProtKB/Swiss-Prot and Genatlas for BAG2 Gene
Publications for BAG2 Gene
- An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S. … Reed J.C. (J. Biol. Chem. 1999) 2 3 4 22 64
- Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PMID: 24318877) Rauch J.N. … Gestwicki J.E. (J. Biol. Chem. 2014) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
Products for BAG2 Gene
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- antibodies-online Antibodies for BAG2: See all 75
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- VectorBuilder custom plasmid, inducible vectors for BAG2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAG2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for BAG2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
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- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (115) ProteomicsDB
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- (141) ENCODE
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- (147) VectorBuilder
- (148) SNPedia
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- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




