Aliases for BAG2 Gene
External Ids for BAG2 Gene
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
GeneCards Summary for BAG2 Gene
BAG2 (BCL2-Associated Athanogene 2) is a Protein Coding gene. Diseases associated with BAG2 include spindle cell hemangioma and brain cancer. Among its related pathways are Protein processing in endoplasmic reticulum and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include chaperone binding.
UniProtKB/Swiss-Prot for BAG2 Gene
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release