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Aliases for BAG2 Gene

Aliases for BAG2 Gene

  • BCL2 Associated Athanogene 2 2 3 5
  • Bcl-2-Associated Athanogene 2 3 4
  • BAG-2 3 4
  • DJ417I1.2 (BAG-Family Molecular Chaperone Regulator 2) 3
  • BAG Family Molecular Chaperone Regulator 2 3
  • DJ417I1.2 3

External Ids for BAG2 Gene

Previous GeneCards Identifiers for BAG2 Gene

  • GC06P057039
  • GC06P057083
  • GC06P057084
  • GC06P056871

Summaries for BAG2 Gene

Entrez Gene Summary for BAG2 Gene

  • BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAG2 Gene

BAG2 (BCL2 Associated Athanogene 2) is a Protein Coding gene. Diseases associated with BAG2 include Spindle Cell Hemangioma. Among its related pathways are Cellular response to heat stress and Cellular Senescence. GO annotations related to this gene include identical protein binding and chaperone binding.

UniProtKB/Swiss-Prot for BAG2 Gene

  • Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.

Gene Wiki entry for BAG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG2 Gene

Genomics for BAG2 Gene

Regulatory Elements for BAG2 Gene

Enhancers for BAG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F057241 1.2 Ensembl ENCODE 15.7 +70.5 70463 1.7 FEZF1 ZNF2 FOS ZNF202 SP3 TSHZ1 ZNF518A ZNF264 NFIL3 ZNF610 BAG2 GUSBP4 KIAA1586 ENSG00000272316 LOC101927211 BEND6 PRIM2 GC06M057241 GC06P057245
GH06F057257 1.1 FANTOM5 Ensembl ENCODE 16.2 +86.2 86227 2.4 ZNF146 ZNF280D RNF2 ZMYM3 ZNF24 BAG2 LOC101927211 RAB23 KIAA1586 LOC100506188 GC06P057245
GH06F057312 1.7 FANTOM5 Ensembl ENCODE 10.3 +143.0 143048 6.4 PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 ENSG00000272316 GUSBP4 BEND6 BAG2 LOC101927211 DST PRIM2 RAB23 GC06M057367
GH06F057261 1 Ensembl ENCODE 16.1 +90.7 90705 2.5 SOX13 PKNOX1 ZNF644 ZBTB40 FOXK2 NFE2 MAFK NFE2L2 RFX1 FOXA3 BAG2 LOC101927211 BEND6 LOC100506188 GC06P057245
GH06F057224 1.1 Ensembl 10.5 +52.7 52695 0.4 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A ZNF2 YY1 KIAA1586 BAG2 LOC101927211 RAB23 GC06M057241
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BAG2 on UCSC Golden Path with GeneCards custom track

Promoters for BAG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001219303 1095 3600 PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS

Genomic Location for BAG2 Gene

Chromosome:
6
Start:
57,172,306 bp from pter
End:
57,189,833 bp from pter
Size:
17,528 bases
Orientation:
Plus strand

Genomic View for BAG2 Gene

Genes around BAG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG2 Gene

Proteins for BAG2 Gene

  • Protein details for BAG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95816-BAG2_HUMAN
    Recommended name:
    BAG family molecular chaperone regulator 2
    Protein Accession:
    O95816
    Secondary Accessions:
    • B4DXE2
    • Q08AS9
    • Q6FID0

    Protein attributes for BAG2 Gene

    Size:
    211 amino acids
    Molecular mass:
    23772 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones. May interact with NWD1 (PubMed:24681825).

    Alternative splice isoforms for BAG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAG2 Gene

Post-translational modifications for BAG2 Gene

  • Ubiquitination at Lys 5, Lys 123, Lys 154, and Lys 200
  • Modification sites at PhosphoSitePlus

Other Protein References for BAG2 Gene

No data available for DME Specific Peptides for BAG2 Gene

Domains & Families for BAG2 Gene

Gene Families for BAG2 Gene

Protein Domains for BAG2 Gene

Suggested Antigen Peptide Sequences for BAG2 Gene

Graphical View of Domain Structure for InterPro Entry

O95816

UniProtKB/Swiss-Prot:

BAG2_HUMAN :
  • Contains 1 BAG domain.
Domain:
  • Contains 1 BAG domain.
genes like me logo Genes that share domains with BAG2: view

Function for BAG2 Gene

Molecular function for BAG2 Gene

GENATLAS Biochemistry:
BCL2-associated athanogene 2 (antiapoptotic). Negative regulator of Hsp70 chaperone activity
UniProtKB/Swiss-Prot Function:
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.

Gene Ontology (GO) - Molecular Function for BAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IPI 18457437
GO:0042802 identical protein binding IPI 22365833
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with BAG2: view
genes like me logo Genes that share phenotypes with BAG2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BAG2 Gene

Localization for BAG2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BAG2 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for BAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with BAG2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BAG2 Gene

Pathways & Interactions for BAG2 Gene

genes like me logo Genes that share pathways with BAG2: view

SIGNOR curated interactions for BAG2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9873016
GO:0019538 protein metabolic process IDA 9873015
GO:0050790 regulation of catalytic activity IEA --
GO:1900034 regulation of cellular response to heat TAS --
genes like me logo Genes that share ontologies with BAG2: view

Transcripts for BAG2 Gene

mRNA/cDNA for BAG2 Gene

Unigene Clusters for BAG2 Gene

BCL2-associated athanogene 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAG2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - -

Relevant External Links for BAG2 Gene

GeneLoc Exon Structure for
BAG2
ECgene alternative splicing isoforms for
BAG2

Expression for BAG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BAG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BAG2 Gene

This gene is overexpressed in Colon - Sigmoid (x5.0).

Protein differential expression in normal tissues from HIPED for BAG2 Gene

This gene is overexpressed in Colon muscle (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BAG2 Gene



Protein tissue co-expression partners for BAG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BAG2 Gene:

BAG2

SOURCE GeneReport for Unigene cluster for BAG2 Gene:

Hs.745046
genes like me logo Genes that share expression patterns with BAG2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for BAG2 Gene

Orthologs for BAG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAG2 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia BAG2 34 35
  • 94.31 (n)
oppossum
(Monodelphis domestica)
Mammalia BAG2 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAG2 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bag2 34 16 35
  • 85.56 (n)
rat
(Rattus norvegicus)
Mammalia Bag2 34
  • 85.08 (n)
cow
(Bos Taurus)
Mammalia BAG2 34 35
  • 84.2 (n)
chicken
(Gallus gallus)
Aves BAG2 34 35
  • 77.78 (n)
lizard
(Anolis carolinensis)
Reptilia BAG2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bag2 34
  • 68.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17323 34
zebrafish
(Danio rerio)
Actinopterygii bag2 34 35
  • 66.67 (n)
zgc64195 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.396 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010983 34
  • 47.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7945 34 35
  • 46.47 (n)
worm
(Caenorhabditis elegans)
Secernentea unc-23 34 35
  • 47.37 (n)
Species where no ortholog for BAG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BAG2 Gene

ENSEMBL:
Gene Tree for BAG2 (if available)
TreeFam:
Gene Tree for BAG2 (if available)

Paralogs for BAG2 Gene

No data available for Paralogs for BAG2 Gene

Variants for BAG2 Gene

Sequence variations from dbSNP and Humsavar for BAG2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1063244 -- 57,172,618(+) GCGAC(C/G)CTGCA upstream-variant-2KB, utr-variant-5-prime
rs1074170 -- 57,178,663(+) CTTGC(A/C)TGAAA intron-variant
rs1074171 -- 57,178,647(+) AGAAT(A/G)ACATT intron-variant
rs111254773 -- 57,180,624(+) ACTGC(A/G)TGCAG intron-variant
rs112572369 -- 57,183,341(+) CTTAT(C/T)TTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAG2 Gene

Variant ID Type Subtype PubMed ID
nsv462949 CNV loss 19166990
nsv603190 CNV loss 21841781

Variation tolerance for BAG2 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BAG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BAG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG2 Gene

Disorders for BAG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BAG2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spindle cell hemangioma
  • sch
- elite association - COSMIC cancer census association via MalaCards
Search BAG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BAG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BAG2
genes like me logo Genes that share disorders with BAG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BAG2 Gene

Publications for BAG2 Gene

  1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S. … Reed J.C. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for BAG2 Gene

Sources for BAG2 Gene

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