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Aliases for BAG2 Gene

Aliases for BAG2 Gene

  • BCL2-Associated Athanogene 2 2 3
  • Bcl-2-Associated Athanogene 2 3 4
  • BAG-2 3 4
  • DJ417I1.2 (BAG-Family Molecular Chaperone Regulator 2) 3
  • BAG Family Molecular Chaperone Regulator 2 3
  • BAG-Family Molecular Chaperone Regulator-2 3
  • DJ417I1.2 3

External Ids for BAG2 Gene

Previous GeneCards Identifiers for BAG2 Gene

  • GC06P057039
  • GC06P057083
  • GC06P057084
  • GC06P056871

Summaries for BAG2 Gene

Entrez Gene Summary for BAG2 Gene

  • BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAG2 Gene

BAG2 (BCL2-Associated Athanogene 2) is a Protein Coding gene. Diseases associated with BAG2 include spindle cell hemangioma and brain cancer. Among its related pathways are Protein processing in endoplasmic reticulum and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot for BAG2 Gene

  • Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release

Gene Wiki entry for BAG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG2 Gene

Genomics for BAG2 Gene

Regulatory Elements for BAG2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BAG2 Gene

Start:
57,172,306 bp from pter
End:
57,189,833 bp from pter
Size:
17,528 bases
Orientation:
Plus strand

Genomic View for BAG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG2 Gene

Proteins for BAG2 Gene

  • Protein details for BAG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95816-BAG2_HUMAN
    Recommended name:
    BAG family molecular chaperone regulator 2
    Protein Accession:
    O95816
    Secondary Accessions:
    • B4DXE2
    • Q08AS9
    • Q6FID0

    Protein attributes for BAG2 Gene

    Size:
    211 amino acids
    Molecular mass:
    23772 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones. May interact with NWD1 (PubMed:24681825).

    Alternative splice isoforms for BAG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAG2 Gene

Proteomics data for BAG2 Gene at MOPED

Post-translational modifications for BAG2 Gene

  • Ubiquitination at Lys5, Lys123, Lys154, and Lys200
  • Modification sites at PhosphoSitePlus

Other Protein References for BAG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BAG2 Gene

Domains for BAG2 Gene

Protein Domains for BAG2 Gene

Suggested Antigen Peptide Sequences for BAG2 Gene

Graphical View of Domain Structure for InterPro Entry

O95816

UniProtKB/Swiss-Prot:

BAG2_HUMAN :
  • O95816
Domain:
  • Contains 1 BAG domain.
genes like me logo Genes that share domains with BAG2: view

No data available for Gene Families for BAG2 Gene

Function for BAG2 Gene

Molecular function for BAG2 Gene

GENATLAS Biochemistry: BCL2-associated athanogene 2 (antiapoptotic). Negative regulator of Hsp70 chaperone activity
UniProtKB/Swiss-Prot Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release

Gene Ontology (GO) - Molecular Function for BAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18457437
GO:0042802 identical protein binding IPI 22365833
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with BAG2: view
genes like me logo Genes that share phenotypes with BAG2: view

Animal Model Products

CRISPR Products

miRNA for BAG2 Gene

miRTarBase miRNAs that target BAG2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BAG2 Gene

Localization for BAG2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAG2 Gene COMPARTMENTS Subcellular localization image for BAG2 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for BAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with BAG2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BAG2 Gene

Pathways for BAG2 Gene

genes like me logo Genes that share pathways with BAG2: view

Pathways by source for BAG2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Heat Shock Proteins & Chaperones in human,mouse,rat

Gene Ontology (GO) - Biological Process for BAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9873016
GO:0019538 protein metabolic process IDA 9873015
GO:0034605 cellular response to heat TAS --
GO:1900034 regulation of cellular response to heat TAS --
genes like me logo Genes that share ontologies with BAG2: view

Transcripts for BAG2 Gene

Unigene Clusters for BAG2 Gene

BCL2-associated athanogene 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BAG2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for BAG2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAG2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - -

Relevant External Links for BAG2 Gene

GeneLoc Exon Structure for
BAG2
ECgene alternative splicing isoforms for
BAG2

Expression for BAG2 Gene

mRNA expression in normal human tissues for BAG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BAG2 Gene

This gene is overexpressed in Colon - Sigmoid (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAG2 Gene

SOURCE GeneReport for Unigene cluster for BAG2 Gene Hs.745046

genes like me logo Genes that share expressions with BAG2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for BAG2 Gene

Orthologs for BAG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAG2 35
  • 100 (n)
  • 100 (a)
BAG2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAG2 35
  • 84.2 (n)
  • 95.26 (a)
BAG2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAG2 35
  • 94.31 (n)
  • 97.63 (a)
BAG2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bag2 35
  • 85.56 (n)
  • 93.81 (a)
Bag2 16
Bag2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BAG2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAG2 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bag2 35
  • 85.08 (n)
  • 92.86 (a)
chicken
(Gallus gallus)
Aves BAG2 35
  • 77.78 (n)
  • 81.92 (a)
BAG2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BAG2 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17323 35
tropical clawed frog
(Silurana tropicalis)
Amphibia bag2 35
  • 68.38 (n)
  • 69.23 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.396 35
zebrafish
(Danio rerio)
Actinopterygii bag2 35
  • 66.67 (n)
  • 66 (a)
bag2 36
  • 63 (a)
OneToOne
zgc64195 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010983 35
  • 47.11 (n)
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7945 35
  • 46.47 (n)
  • 40 (a)
CG7945 36
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-23 35
  • 47.37 (n)
  • 40.35 (a)
unc-23 36
  • 16 (a)
OneToOne
Species with no ortholog for BAG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BAG2 Gene

ENSEMBL:
Gene Tree for BAG2 (if available)
TreeFam:
Gene Tree for BAG2 (if available)

Paralogs for BAG2 Gene

No data available for Paralogs for BAG2 Gene

Variants for BAG2 Gene

Sequence variations from dbSNP and Humsavar for BAG2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs723020 -- 57,178,484(+) GAGGA(A/G)GGGGG intron-variant
rs1074170 -- 57,178,663(+) CTTGC(A/C/G)TGAAA intron-variant
rs1074171 -- 57,178,647(+) AGAAT(A/G)ACATT intron-variant
rs2039213 -- 57,178,957(+) AAATG(A/G)AACCT intron-variant
rs3031131 -- 57,185,669(+) ACTTG(-/GTTT)GTTAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for BAG2 Gene

Variant ID Type Subtype PubMed ID
nsv462949 CNV Loss 19166990

Relevant External Links for BAG2 Gene

HapMap Linkage Disequilibrium report
BAG2

PCR Panel Products

  • Copy Number PCR Panels: for BAG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG2 Gene

Disorders for BAG2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for BAG2 Gene including...

Search for BAG2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for BAG2 Gene

genes like me logo Genes that share disorders with BAG2: view

No data available for UniProtKB/Swiss-Prot for BAG2 Gene

Publications for BAG2 Gene

  1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S. … Reed J.C. (J. Biol. Chem. 1999) 2 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for BAG2 Gene

Sources for BAG2 Gene

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