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Aliases for BAG2 Gene

Aliases for BAG2 Gene

  • BCL2 Associated Athanogene 2 2 3 5
  • Bcl-2-Associated Athanogene 2 3 4
  • BAG-2 3 4
  • DJ417I1.2 (BAG-Family Molecular Chaperone Regulator 2) 3
  • BAG-Family Molecular Chaperone Regulator-2 3
  • BCL2-Associated Athanogene 2 3
  • DJ417I1.2 3

External Ids for BAG2 Gene

Previous GeneCards Identifiers for BAG2 Gene

  • GC06P057039
  • GC06P057083
  • GC06P057084
  • GC06P056871

Summaries for BAG2 Gene

Entrez Gene Summary for BAG2 Gene

  • BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAG2 Gene

BAG2 (BCL2 Associated Athanogene 2) is a Protein Coding gene. Diseases associated with BAG2 include Spindle Cell Hemangioma. Among its related pathways are Cellular response to heat stress and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include identical protein binding and chaperone binding.

UniProtKB/Swiss-Prot for BAG2 Gene

  • Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.

Gene Wiki entry for BAG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG2 Gene

Genomics for BAG2 Gene

Regulatory Elements for BAG2 Gene

Enhancers for BAG2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BAG2 on UCSC Golden Path with GeneCards custom track

Promoters for BAG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BAG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BAG2 Gene

57,172,306 bp from pter
57,189,833 bp from pter
17,528 bases
Plus strand

Genomic View for BAG2 Gene

Genes around BAG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG2 Gene

Proteins for BAG2 Gene

  • Protein details for BAG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BAG family molecular chaperone regulator 2
    Protein Accession:
    Secondary Accessions:
    • B4DXE2
    • Q08AS9
    • Q6FID0

    Protein attributes for BAG2 Gene

    211 amino acids
    Molecular mass:
    23772 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones. May interact with NWD1 (PubMed:24681825).

    Alternative splice isoforms for BAG2 Gene


neXtProt entry for BAG2 Gene

Proteomics data for BAG2 Gene at MOPED

Post-translational modifications for BAG2 Gene

  • Ubiquitination at Lys 5, Lys 123, Lys 154, and Lys 200
  • Modification sites at PhosphoSitePlus

Other Protein References for BAG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BAG2 Gene

Domains & Families for BAG2 Gene

Gene Families for BAG2 Gene

Protein Domains for BAG2 Gene

Suggested Antigen Peptide Sequences for BAG2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BAG domain.
  • Contains 1 BAG domain.
genes like me logo Genes that share domains with BAG2: view

Function for BAG2 Gene

Molecular function for BAG2 Gene

GENATLAS Biochemistry:
BCL2-associated athanogene 2 (antiapoptotic). Negative regulator of Hsp70 chaperone activity
UniProtKB/Swiss-Prot Function:
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.

Gene Ontology (GO) - Molecular Function for BAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with BAG2: view
genes like me logo Genes that share phenotypes with BAG2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BAG2 Gene

Localization for BAG2 Gene

Subcellular locations from

Jensen Localization Image for BAG2 Gene COMPARTMENTS Subcellular localization image for BAG2 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BAG2 Gene

Pathways & Interactions for BAG2 Gene

genes like me logo Genes that share pathways with BAG2: view

SIGNOR curated interactions for BAG2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9873016
GO:0034605 cellular response to heat TAS --
genes like me logo Genes that share ontologies with BAG2: view

Drugs & Compounds for BAG2 Gene

No Compound Related Data Available

Transcripts for BAG2 Gene

mRNA/cDNA for BAG2 Gene

Unigene Clusters for BAG2 Gene

BCL2-associated athanogene 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BAG2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - -

Relevant External Links for BAG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BAG2 Gene

mRNA expression in normal human tissues for BAG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BAG2 Gene

This gene is overexpressed in Colon - Sigmoid (x5.0).

Protein differential expression in normal tissues from HIPED for BAG2 Gene

This gene is overexpressed in Colon muscle (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAG2 Gene

SOURCE GeneReport for Unigene cluster for BAG2 Gene Hs.745046

genes like me logo Genes that share expression patterns with BAG2: view

Protein tissue co-expression partners for BAG2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for BAG2 Gene

Orthologs for BAG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BAG2 35
  • 84.2 (n)
  • 95.26 (a)
BAG2 36
  • 95 (a)
(Canis familiaris)
Mammalia BAG2 35
  • 94.31 (n)
  • 97.63 (a)
BAG2 36
  • 98 (a)
(Mus musculus)
Mammalia Bag2 35
  • 85.56 (n)
  • 93.81 (a)
Bag2 16
Bag2 36
  • 94 (a)
(Pan troglodytes)
Mammalia BAG2 35
  • 100 (n)
  • 100 (a)
BAG2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Bag2 35
  • 85.08 (n)
  • 92.86 (a)
(Monodelphis domestica)
Mammalia BAG2 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia BAG2 36
  • 89 (a)
(Gallus gallus)
Aves BAG2 35
  • 77.78 (n)
  • 81.92 (a)
BAG2 36
  • 78 (a)
(Anolis carolinensis)
Reptilia BAG2 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bag2 35
  • 68.38 (n)
  • 69.23 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17323 35
(Danio rerio)
Actinopterygii bag2 35
  • 66.67 (n)
  • 66 (a)
zgc64195 35
bag2 36
  • 63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.396 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010983 35
  • 47.11 (n)
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7945 35
  • 46.47 (n)
  • 40 (a)
CG7945 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea unc-23 35
  • 47.37 (n)
  • 40.35 (a)
unc-23 36
  • 16 (a)
Species with no ortholog for BAG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BAG2 Gene

Gene Tree for BAG2 (if available)
Gene Tree for BAG2 (if available)

Paralogs for BAG2 Gene

No data available for Paralogs for BAG2 Gene

Variants for BAG2 Gene

Sequence variations from dbSNP and Humsavar for BAG2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1074170 -- 57,178,663(+) CTTGC(A/C/G)TGAAA intron-variant
rs1074171 -- 57,178,647(+) AGAAT(A/G)ACATT intron-variant
rs9885757 -- 57,183,660(+) AGTTT(C/T)AGCTT intron-variant
rs11366557 -- 57,176,898(+) GGTCC(-/A)ATTAG intron-variant
rs2039213 -- 57,178,957(+) AAATG(A/G)AACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAG2 Gene

Variant ID Type Subtype PubMed ID
nsv462949 CNV Loss 19166990

Variation tolerance for BAG2 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BAG2 Gene

Disorders for BAG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BAG2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spindle cell hemangioma
  • sch
- elite association - COSMIC cancer census association via MalaCards
Search BAG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BAG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BAG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BAG2 Gene

Publications for BAG2 Gene

  1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S. … Reed J.C. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. The BAG2 and BAG5 proteins inhibit the ubiquitination of pathogenic ataxin3-80Q. (PMID: 25006867) Che X.Q. … Guo J.F. (Int. J. Neurosci. 2015) 3
  3. DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. (PMID: 25756610) Papp S.J. … Lamia K.A. (Elife 2015) 3
  4. Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. (PMID: 25817432) Gallina I. … Lisby M. (Nat Commun 2015) 3
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for BAG2 Gene

Sources for BAG2 Gene