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Aliases for BAG1 Gene

Aliases for BAG1 Gene

  • BCL2-Associated Athanogene 2 3
  • BAG-1 3 4
  • HAP 3 4
  • Glucocortoid Receptor-Associated Protein RAP46 3
  • Bcl-2 Associating Athanogene-1 Protein 3
  • Receptor-Associated Protein, 46-KD 3
  • Bcl-2-Associated Athanogene 1 4
  • Bcl-2-Binding Protein 3
  • RAP46 3

External Ids for BAG1 Gene

Previous GeneCards Identifiers for BAG1 Gene

  • GC09M033567
  • GC09M033423
  • GC09M033244

Summaries for BAG1 Gene

Entrez Gene Summary for BAG1 Gene

  • The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]

GeneCards Summary for BAG1 Gene

BAG1 (BCL2-Associated Athanogene) is a Protein Coding gene. Diseases associated with BAG1 include spindle cell hemangioma and lung cancer. Among its related pathways are Cellular Senescence and Androgen receptor signaling pathway. GO annotations related to this gene include chaperone binding and phosphoprotein binding.

UniProtKB/Swiss-Prot for BAG1 Gene

  • Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.

Gene Wiki entry for BAG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG1 Gene

Genomics for BAG1 Gene

Regulatory Elements for BAG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BAG1 Gene

Chromosome:
9
Start:
33,247,820 bp from pter
End:
33,264,763 bp from pter
Size:
16,944 bases
Orientation:
Minus strand

Genomic View for BAG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG1 Gene

Proteins for BAG1 Gene

  • Protein details for BAG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99933-BAG1_HUMAN
    Recommended name:
    BAG family molecular chaperone regulator 1
    Protein Accession:
    Q99933
    Secondary Accessions:
    • O75315
    • Q14414
    • Q53H32
    • Q5VZE8
    • Q5VZE9
    • Q5VZF0
    • Q96TG2
    • Q9Y2V4

    Protein attributes for BAG1 Gene

    Size:
    345 amino acids
    Molecular mass:
    38779 Da
    Quaternary structure:
    • Homodimer. Forms a heteromeric complex with HSP70/HSC70. Binds to the ATPase domain of HSP/HSC70 chaperones. Isoform 1, isoform 3 and isoform 4 but not isoform 2 interact with HSPA8/HSC70. Interacts with NR3C1. Interacts with the N-terminal region of STK19. Interacts with PPP1R15A. Interacts with BCL2 in an ATP-dependent manner. Isoform 2 does not interact with BCL2.
    SequenceCaution:
    • Sequence=AAD11467.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD25045.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD96469.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAA84624.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH72516.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72518.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72741.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72742.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW58515.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BAG1 Gene

    Alternative splice isoforms for BAG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAG1 Gene

Proteomics data for BAG1 Gene at MOPED

Post-translational modifications for BAG1 Gene

  • Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • Ubiquitination at Lys 273
  • Modification sites at PhosphoSitePlus

Other Protein References for BAG1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BAG1 (BAG1)

No data available for DME Specific Peptides for BAG1 Gene

Domains & Families for BAG1 Gene

Gene Families for BAG1 Gene

Suggested Antigen Peptide Sequences for BAG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99933

UniProtKB/Swiss-Prot:

BAG1_HUMAN :
  • Contains 1 BAG domain.
Domain:
  • Contains 1 BAG domain.
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with BAG1: view

Function for BAG1 Gene

Molecular function for BAG1 Gene

GENATLAS Biochemistry:
BCL2-associated athanogene 1 (antiapoptotic),negative regulator of Hsp70 chaperone activity,multifunctional protein interacting with several types of proteins,including BCL2 family proteins,certain tyrosine-kinase receptors such as hepatocyte growth factor receptor (MET) and PDGFR and steroid receptors,mouse Bag1 homolog,with four isoforms (50,46 (RAP46),33 and 29kDa),overexpressed in cervical,breast (invasive carcinomas) and lung cancer cell lines
UniProtKB/Swiss-Prot Function:
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.
UniProtKB/Swiss-Prot Induction:
Up-regulated during differentiation of bladder epithelial cells and down-regulated during differentiation of prostate epithelium.

Gene Ontology (GO) - Molecular Function for BAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity TAS 8947043
GO:0005515 protein binding IPI 9305631
GO:0051087 chaperone binding IEA --
GO:0051219 phosphoprotein binding --
genes like me logo Genes that share ontologies with BAG1: view
genes like me logo Genes that share phenotypes with BAG1: view

Animal Models for BAG1 Gene

MGI Knock Outs for BAG1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BAG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BAG1 Gene

Localization for BAG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAG1 Gene

Isoform 1: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus.
Isoform 2: Cytoplasm. Nucleus. Note=Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock.
Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAG1 Gene COMPARTMENTS Subcellular localization image for BAG1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
endoplasmic reticulum 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for BAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9679980
GO:0005737 cytoplasm TAS 8947043
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with BAG1: view

Pathways & Interactions for BAG1 Gene

genes like me logo Genes that share pathways with BAG1: view

Pathways by source for BAG1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for BAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation --
GO:0006915 apoptotic process IEA --
GO:0007166 cell surface receptor signaling pathway TAS 8947043
GO:0030182 neuron differentiation --
GO:0034605 cellular response to heat TAS --
genes like me logo Genes that share ontologies with BAG1: view

No data available for SIGNOR curated interactions for BAG1 Gene

Drugs & Compounds for BAG1 Gene

(15) Drugs for BAG1 Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Fludarabine Approved Pharma DNA synthsis inhibitor 1008
Paclitaxel Approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 2505
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453

(5) Additional Compounds for BAG1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Cycloheximide
N-(4-hydroxyphenyl)retinamide
retinoic acid
302-79-4
Steroid
genes like me logo Genes that share compounds with BAG1: view

Transcripts for BAG1 Gene

Unigene Clusters for BAG1 Gene

BCL2-associated athanogene:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BAG1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAG1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - - -
SP2:
SP3: -
SP4:
SP5: - -

Relevant External Links for BAG1 Gene

GeneLoc Exon Structure for
BAG1
ECgene alternative splicing isoforms for
BAG1

Expression for BAG1 Gene

mRNA expression in normal human tissues for BAG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BAG1 Gene

This gene is overexpressed in Heart (19.4), Peripheral blood mononuclear cells (13.6), and Retina (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAG1 Gene



SOURCE GeneReport for Unigene cluster for BAG1 Gene Hs.377484

mRNA Expression by UniProt/SwissProt for BAG1 Gene

Q99933-BAG1_HUMAN
Tissue specificity: Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level).
genes like me logo Genes that share expression patterns with BAG1: view

Protein tissue co-expression partners for BAG1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BAG1 Gene

Orthologs for BAG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BAG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BAG1 35
  • 88.09 (n)
  • 84.26 (a)
BAG1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAG1 35
  • 87.81 (n)
  • 83.12 (a)
BAG1 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bag1 35
  • 81.64 (n)
  • 73.62 (a)
Bag1 16
Bag1 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BAG1 35
  • 99.42 (n)
  • 99.57 (a)
BAG1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bag1 35
  • 81.16 (n)
  • 72.46 (a)
oppossum
(Monodelphis domestica)
Mammalia BAG1 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves BAG1 35
  • 71.66 (n)
  • 69.57 (a)
BAG1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bag1 35
  • 66.5 (n)
  • 64.71 (a)
Str.17686 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19139 35
zebrafish
(Danio rerio)
Actinopterygii bag1 35
  • 62.78 (n)
  • 59.22 (a)
bag1 36
  • 59 (a)
OneToOne
Species with no ortholog for BAG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAG1 Gene

ENSEMBL:
Gene Tree for BAG1 (if available)
TreeFam:
Gene Tree for BAG1 (if available)

Paralogs for BAG1 Gene

Pseudogenes.org Pseudogenes for BAG1 Gene

genes like me logo Genes that share paralogs with BAG1: view

No data available for Paralogs for BAG1 Gene

Variants for BAG1 Gene

Sequence variations from dbSNP and Humsavar for BAG1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs533080047 -- 33,261,383(+) TATTC(A/C)GTGCA intron-variant
rs533045712 -- 33,254,029(+) CTGGA(A/G)TGCAG utr-variant-3-prime
rs532920947 -- 33,253,549(+) GGGTG(C/T)GGTGG utr-variant-3-prime
rs532671501 -- 33,256,168(+) GGCCA(C/T)AGGAA intron-variant
rs532495262 -- 33,256,991(+) ATCAC(A/C)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAG1 Gene

Variant ID Type Subtype PubMed ID
nsv893017 CNV Gain 21882294
nsv519369 CNV Gain 19592680
esv2463163 CNV Deletion 19546169

Variation tolerance for BAG1 Gene

Residual Variation Intolerance Score: 81.97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BAG1 Gene

HapMap Linkage Disequilibrium report
BAG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG1 Gene

Disorders for BAG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BAG1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
spindle cell hemangioma
  • spindle cell hemangioendothelioma [dup]
lung cancer
  • lung cancer, protection against
- elite association
Search BAG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BAG1

Genetic Association Database (GAD)
BAG1
Human Genome Epidemiology (HuGE) Navigator
BAG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BAG1
genes like me logo Genes that share disorders with BAG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BAG1 Gene

Publications for BAG1 Gene

  1. Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. (PMID: 7834747) Takayama S. … Reed J.C. (Cell 1995) 2 23 67
  2. Nuclear or cytoplasmic localization of Bag-1 distinctly correlates with pathologic behavior and outcome of gastric carcinomas. (PMID: 20096920) Zheng H.C. … Takano Y. (Hum. Pathol. 2010) 23 67
  3. BAG-1 overexpression attenuates luminal apoptosis in MCF-10A mammary epithelial cells through enhanced RAF-1 activation. (PMID: 19881545) Anderson L.R. … Butt A.J. (Oncogene 2010) 23 67
  4. Different BAG-1 isoforms have distinct functions in modulating chemotherapeutic-induced apoptosis in breast cancer cells. (PMID: 19151744) Liu H.Y. … Chen J. (Acta Pharmacol. Sin. 2009) 23 67
  5. CD24 expression has a prognostic impact in breast carcinoma. (PMID: 19243896) Athanassiadou P. … Patsouris E. (Pathol. Res. Pract. 2009) 23 67

Products for BAG1 Gene

Sources for BAG1 Gene

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