Aliases for BAG1 Gene
Aliases for BAG1 Gene
External Ids for BAG1 Gene
- HGNC: 937
- Entrez Gene: 573
- Ensembl: ENSG00000107262
- OMIM: 601497
- UniProtKB: Q99933
Previous GeneCards Identifiers for BAG1 Gene
- GC09M033567
- GC09M033423
- GC09M033244
Summaries for BAG1 Gene
-
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]
GeneCards Summary for BAG1 Gene
BAG1 (BCL2 Associated Athanogene 1) is a Protein Coding gene. Diseases associated with BAG1 include Spindle Cell Hemangioma and Lung Cancer. Among its related pathways are Protein processing in endoplasmic reticulum and Cellular response to heat stress. GO annotations related to this gene include chaperone binding and phosphoprotein binding.
UniProtKB/Swiss-Prot for BAG1 Gene
-
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG1 Gene
Genomics for BAG1 Gene
Regulatory Elements for BAG1 Gene
Enhancers for BAG1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around BAG1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for BAG1 Gene
- Chromosome:
- 9
- Start:
- 33,247,820 bp from pter
- End:
- 33,264,761 bp from pter
- Size:
- 16,942 bases
- Orientation:
- Minus strand
Genomic View for BAG1 Gene
Genes around BAG1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p13.3 by Ensembl
- 9p13.3 by Entrez Gene
- 9p13.3 by HGNC
BAG1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BAG1 Gene
Proteins for BAG1 Gene
-
Protein details for BAG1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99933-BAG1_HUMAN
- Recommended name:
- BAG family molecular chaperone regulator 1
- Protein Accession:
- Q99933
- O75315
- Q14414
- Q53H32
- Q5VZE8
- Q5VZE9
- Q5VZF0
- Q96TG2
- Q9Y2V4
Protein attributes for BAG1 Gene
- Size:
- 345 amino acids
- Molecular mass:
- 38779 Da
- Quaternary structure:
-
- Homodimer. Forms a heteromeric complex with HSP70/HSC70 (PubMed:9305631). Binds to the ATPase domain of HSP/HSC70 chaperones. Isoform 1, isoform 3 and isoform 4 but not isoform 2 interact with HSPA8/HSC70 (PubMed:27474739, PubMed:24318877, PubMed:9305631, PubMed:9679980). Interacts with NR3C1 (PubMed:10477749). Interacts with the N-terminal region of STK19 (PubMed:15986447). Interacts with PPP1R15A (PubMed:12724406). Interacts with BCL2 in an ATP-dependent manner. Isoform 2 does not interact with BCL2 (PubMed:9305631). Interacts with SIAH1 (PubMed:9582267). Interacts with HSPA8 (via NBD) (PubMed:27474739, PubMed:24318877). Interacts with HSPA1A (via NBD) and HSPA1B (via NBD) (PubMed:24318877). Interacts with SIAH2 (By similarity).
- SequenceCaution:
-
- Sequence=AAD11467.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD25045.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD96469.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAA84624.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH72516.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72518.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72741.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72742.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW58515.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for BAG1 Gene
Protein Expression for BAG1 Gene
Post-translational modifications for BAG1 Gene
- Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
- Ubiquitination at posLast=273273
- Modification sites at PhosphoSitePlus
Other Protein References for BAG1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for BAG1
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Santa Cruz Biotechnology (SCBT) Antibodies for BAG1
Protein Products
- Enzo Life Sciences proteins for BAG1
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-
Cloud-Clone Corp. Proteins for BAG1
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Assay Products
- antibodies-online Kits for BAG1: See all 3
No data available for DME Specific Peptides for BAG1 Gene
Domains & Families for BAG1 Gene
Gene Families for BAG1 Gene
Protein Domains for BAG1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for BAG1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for BAG1 Gene
Function for BAG1 Gene
Molecular function for BAG1 Gene
- GENATLAS Biochemistry:
- BCL2-associated athanogene 1 (antiapoptotic),negative regulator of Hsp70 chaperone activity,multifunctional protein interacting with several types of proteins,including BCL2 family proteins,certain tyrosine-kinase receptors such as hepatocyte growth factor receptor (MET) and PDGFR and steroid receptors,mouse Bag1 homolog,with four isoforms (50,46 (RAP46),33 and 29kDa),overexpressed in cervical,breast (invasive carcinomas) and lung cancer cell lines
- UniProtKB/Swiss-Prot Function:
- Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).
- UniProtKB/Swiss-Prot Induction:
- Up-regulated during differentiation of bladder epithelial cells and down-regulated during differentiation of prostate epithelium.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000774 | adenyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005057 | signal transducer activity, downstream of receptor | TAS | 8947043 |
| GO:0005515 | protein binding | IPI | 9305631 |
| GO:0051087 | chaperone binding | IEA | -- |
Phenotypes for BAG1 Gene
- MGI mutant phenotypes for BAG1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for BAG1:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
Animal Model Products
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-
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miRNA for BAG1 Gene
- miRTarBase miRNAs that target BAG1
miRNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BAG1 Gene
Localization for BAG1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BAG1 Gene
- Isoform 1: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus.
- Isoform 2: Cytoplasm. Nucleus. Note=Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock.
- Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 9679980 |
| GO:0005737 | cytoplasm | TAS | 8947043 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for BAG1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular response to heat stress | ||
| 2 | Protein processing in endoplasmic reticulum | ||
| 3 | Cellular Senescence | ||
| 4 | Androgen receptor signaling pathway | ||
Pathways by source for BAG1 Gene
1 BioSystems pathway for BAG1 Gene
3 Reactome pathways for BAG1 Gene
1 KEGG pathway for BAG1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007166 | cell surface receptor signaling pathway | TAS | 8947043 |
| GO:0043066 | negative regulation of apoptotic process | TAS | 8947043 |
| GO:0050790 | regulation of catalytic activity | IEA | -- |
| GO:0070389 | chaperone cofactor-dependent protein refolding | IDA | 12853476 |
No data available for SIGNOR curated interactions for BAG1 Gene
Drugs & Compounds for BAG1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for BAG1 Gene
mRNA/cDNA for BAG1 Gene
- (4) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (321) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for BAG1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for BAG1
-
Santa Cruz Biotechnology (SCBT) CRISPR for BAG1
- GenScript: Design CRISPR guide RNA sequences for BAG1
miRNA Products
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Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for BAG1
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-
ViGene Biosciences ready-to-package AAV shRNAs for BAG1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for BAG1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAG1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||
| SP5: | - | - |
Expression for BAG1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Heart (19.4), Peripheral blood mononuclear cells (13.6), and Retina (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BAG1 Gene
NURSA nuclear receptor signaling pathways regulating expression of BAG1 Gene:
BAG1SOURCE GeneReport for Unigene cluster for BAG1 Gene:
Hs.377484mRNA Expression by UniProt/SwissProt for BAG1 Gene:
Q99933-BAG1_HUMAN
Tissue specificity:
Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level).
Evidence on tissue expression from TISSUES for BAG1 Gene
- Lung(4.6)
- Liver(4.4)
- Blood(4.3)
- Nervous system(3.5)
- Muscle(3.1)
- Heart(2.3)
- Kidney(2.2)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for BAG1
-
OriGene qPCR primer pairs and template standards for BAG1
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAG1 Gene
Orthologs for BAG1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BAG1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | BAG1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | BAG1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Bag1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bag1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | BAG1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BAG1 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bag1 34 |
|
||
| Str.17686 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.19139 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | bag1 34 35 |
|
- Species where no ortholog for BAG1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for BAG1 Gene
Pseudogenes.org Pseudogenes for BAG1 Gene
No data available for Paralogs for BAG1 Gene
Variants for BAG1 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000234535 | -- | 33,263,396(+) | GTAAA(C/G)AGACA | intron-variant, upstream-variant-2KB | |
| rs1000774456 | -- | 33,257,209(+) | CACAG(A/G)TTTAG | intron-variant | |
| rs1000982073 | -- | 33,264,981(+) | ATATT(A/G)CGCTT | upstream-variant-2KB, utr-variant-5-prime | |
| rs1001269373 | -- | 33,253,698(+) | AAAGG(G/T)CTACT | utr-variant-3-prime | |
| rs1001287597 | -- | 33,264,657(+) | CGCGC(A/C/G/T)CCCCC | upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv7516n100 | CNV | gain | 25217958 |
| esv2463163 | CNV | deletion | 19546169 |
| esv2762813 | CNV | gain | 21179565 |
| nsv1023246 | CNV | gain | 25217958 |
| nsv519369 | CNV | gain | 19592680 |
| nsv614146 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.93;
49.06% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for BAG1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BAG1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG1 Gene
Disorders for BAG1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spindle cell hemangioma |
|
|
| lung cancer |
|
Search BAG1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for BAG1
No data available for UniProtKB/Swiss-Prot and Genatlas for BAG1 Gene
Publications for BAG1 Gene
- Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. (PMID: 12724406) Hung W.J. … Wu D.Y. (Mol. Cell. Biol. 2003) 3 4 22 64
- p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. (PMID: 9582267) Matsuzawa S. … Reed J.C. (EMBO J. 1998) 3 4 22 64
- Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. (PMID: 9679980) Takayama S. … Reed J.C. (Cancer Res. 1998) 3 4 22 64
- BAG-1 modulates the chaperone activity of Hsp70/Hsc70. (PMID: 9305631) Takayama S. … Reed J.C. (EMBO J. 1997) 3 4 22 64
- Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation. (PMID: 9396724) Packham G. … Cleveland J.L. (Biochem. J. 1997) 3 4 22 64
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- Cyagen custom Knockout/knockin (KOKI) mouse models for BAG1
- VectorBuilder custom plasmid, inducible vectors for BAG1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAG1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for BAG1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer