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Aliases for BAG1 Gene

Aliases for BAG1 Gene

  • BCL2-Associated Athanogene 2 3
  • BAG-1 3 4
  • HAP 3 4
  • Glucocortoid Receptor-Associated Protein RAP46 3
  • BAG Family Molecular Chaperone Regulator 1 3
  • Bcl-2 Associating Athanogene-1 Protein 3
  • Receptor-Associated Protein, 46-KD 3
  • Bcl-2-Associated Athanogene 1 4
  • Bcl-2-Binding Protein 3
  • RAP46 3

External Ids for BAG1 Gene

Summaries for BAG1 Gene

Entrez Gene Summary for BAG1 Gene

  • The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]

GeneCards Summary for BAG1 Gene

BAG1 (BCL2-Associated Athanogene) is a Protein Coding gene. Diseases associated with BAG1 include spindle cell hemangioma. Among its related pathways are Androgen receptor signaling pathway and Protein processing in endoplasmic reticulum. GO annotations related to this gene include chaperone binding and receptor signaling protein activity.

UniProtKB/Swiss-Prot for BAG1 Gene

  • Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.

Gene Wiki entry for BAG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG1 Gene

Genomics for BAG1 Gene

Genomic Location for BAG1 Gene

Start:
33,247,820 bp from pter
End:
33,264,763 bp from pter
Size:
16,944 bases
Orientation:
Minus strand

Genomic View for BAG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG1 Gene

Regulatory Elements for BAG1 Gene

Proteins for BAG1 Gene

  • Protein details for BAG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99933-BAG1_HUMAN
    Recommended name:
    BAG family molecular chaperone regulator 1
    Protein Accession:
    Q99933
    Secondary Accessions:
    • O75315
    • Q14414
    • Q53H32
    • Q5VZE8
    • Q5VZE9
    • Q5VZF0
    • Q96TG2
    • Q9Y2V4

    Protein attributes for BAG1 Gene

    Size:
    345 amino acids
    Molecular mass:
    38779 Da
    Quaternary structure:
    • Homodimer. Forms a heteromeric complex with HSP70/HSC70. Binds to the ATPase domain of HSP/HSC70 chaperones. Isoform 1, isoform 3 and isoform 4 but not isoform 2 interact with HSPA8/HSC70. Interacts with NR3C1. Interacts with the N-terminal region of STK19. Interacts with PPP1R15A. Interacts with BCL2 in an ATP-dependent manner. Isoform 2 does not interact with BCL2.
    SequenceCaution:
    • Sequence=AAD11467.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD25045.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD96469.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAA84624.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH72516.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72518.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72741.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72742.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW58515.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BAG1 Gene

    Alternative splice isoforms for BAG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAG1 Gene

Proteomics data for BAG1 Gene at MOPED

Post-translational modifications for BAG1 Gene

  • Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys273

Other Protein References for BAG1 Gene

No data available for DME Specific Peptides for BAG1 Gene

Domains for BAG1 Gene

UniProtKB/Swiss-Prot:

BAG1_HUMAN
Domain:
  • Contains 1 BAG domain.:
    • Q99933
  • Contains 1 ubiquitin-like domain.:
    • Q99933
genes like me logo Genes that share domains with BAG1: view

No data available for Gene Families for BAG1 Gene

Function for BAG1 Gene

Molecular function for BAG1 Gene

GENATLAS Biochemistry: BCL2-associated athanogene 1 (antiapoptotic),negative regulator of Hsp70 chaperone activity,multifunctional protein interacting with several types of proteins,including BCL2 family proteins,certain tyrosine-kinase receptors such as hepatocyte growth factor receptor (MET) and PDGFR and steroid receptors,mouse Bag1 homolog,with four isoforms (50,46 (RAP46),33 and 29kDa),overexpressed in cervical,breast (invasive carcinomas) and lung cancer cell lines
UniProtKB/Swiss-Prot Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.
UniProtKB/Swiss-Prot Induction: Up-regulated during differentiation of bladder epithelial cells and down-regulated during differentiation of prostate epithelium.

Gene Ontology (GO) - Molecular Function for BAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity TAS 8947043
GO:0005515 protein binding IPI 19060904
GO:0051087 chaperone binding IEA --
GO:0051219 phosphoprotein binding --
genes like me logo Genes that share ontologies with BAG1: view
genes like me logo Genes that share phenotypes with BAG1: view

Animal Models for BAG1 Gene

MGI Knock Outs for BAG1:

miRNA for BAG1 Gene

miRTarBase miRNAs that target BAG1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BAG1 Gene

Localization for BAG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAG1 Gene

Isoform 1: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus.
Isoform 2: Cytoplasm. Nucleus. Note=Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock.
Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAG1 Gene COMPARTMENTS Subcellular localization image for BAG1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for BAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm TAS 8947043
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with BAG1: view

Pathways for BAG1 Gene

genes like me logo Genes that share pathways with BAG1: view

Pathways by source for BAG1 Gene

1 BioSystems pathway for BAG1 Gene
1 KEGG pathway for BAG1 Gene

Gene Ontology (GO) - Biological Process for BAG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation --
GO:0006915 apoptotic process IEA --
GO:0007166 cell surface receptor signaling pathway TAS 8947043
GO:0030182 neuron differentiation --
GO:0034605 cellular response to heat TAS --
genes like me logo Genes that share ontologies with BAG1: view

Compounds for BAG1 Gene

(19) ApexBio Compounds for BAG1 Gene

Compound Action Cas Number
2,3-DCPE hydrochloride Selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. [418788-90-6]
ABT-199 Selective Bcl-2 inhibitor [1257044-40-8]
ABT-263 (Navitoclax) orally sellecitive inhibitor of Bcl-2 family proteins [923564-51-6]
ABT-737 novel and potent inhibitor of BCL-2 family proteins [852808-04-9]
Apogossypolone (ApoG2) pan Bcl-2 inhibitor [886578-07-0]
AT-101 R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 [90141-22-3]
Bax channel blocker Potent inhibitor of Bax-mediated mitochondrial cytochrome c release. [335165-68-9]
Bax inhibitor peptide P5 Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria [579492-83-4]
Bax inhibitor peptide V5 Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria [579492-81-2]
Bax inhibitor peptide, negative control Negative control peptide for the Bax inhibitor peptides V5 and P5 [1315378-74-5]
BM-1074 potent and efficacious Bcl-2/Bcl-xL inhibitor [1391108-10-3]
Gambogic Acid activates caspases with EC50 of 0.78-1.64 uM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 [2752-65-0]
HA14-1 non-peptidic ligand of a Bcl-2 [65673-63-4]
Marinopyrrole A novel and specific Mcl-1 inhibitor [1227962-62-0]
MIM1 Inhibitor of Mcl-1
Obatoclax mesylate (GX15-070) potently inhibits BCL-2 family [803712-79-0]
Sabutoclax pan-Bcl-2 inhibitor [1228108-65-3]
TW-37 potent small-molecule inhibitor of BCL-2 [877877-35-5]
WEHI-539 high affinity (subnanomolar) and selectivity for BCL-XL [1431866-33-9]

(1) Drugbank Compounds for BAG1 Gene

(19) Novoseek inferred chemical compound relationships for BAG1 Gene

Compound -log(P) Hits PubMed IDs
n-(4-hydroxyphenyl)retinamide 52 6
steroid 38.1 17
nocodazole 35.5 1
fludarabine 31.3 3
paclitaxel 30.9 2
genes like me logo Genes that share compounds with BAG1: view

Transcripts for BAG1 Gene

Unigene Clusters for BAG1 Gene

BCL2-associated athanogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BAG1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - - -
SP2:
SP3: -
SP4:
SP5: - -

Relevant External Links for BAG1 Gene

GeneLoc Exon Structure for
BAG1
ECgene alternative splicing isoforms for
BAG1

Expression for BAG1 Gene

mRNA expression in normal human tissues for BAG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAG1 Gene

SOURCE GeneReport for Unigene cluster for BAG1 Gene Hs.377484

mRNA Expression by UniProt/SwissProt for BAG1 Gene

Q99933-BAG1_HUMAN
Tissue specificity: Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level).
genes like me logo Genes that share expressions with BAG1: view

Orthologs for BAG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BAG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAG1 36
  • 99.42 (n)
  • 99.57 (a)
BAG1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAG1 36
  • 88.09 (n)
  • 84.26 (a)
BAG1 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAG1 36
  • 87.81 (n)
  • 83.12 (a)
BAG1 37
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bag1 36
  • 81.64 (n)
  • 73.62 (a)
Bag1 16
Bag1 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BAG1 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bag1 36
  • 81.16 (n)
  • 72.46 (a)
chicken
(Gallus gallus)
Aves BAG1 36
  • 71.66 (n)
  • 69.57 (a)
BAG1 37
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19139 36
tropical clawed frog
(Silurana tropicalis)
Amphibia bag1 36
  • 66.5 (n)
  • 64.71 (a)
Str.17686 36
zebrafish
(Danio rerio)
Actinopterygii bag1 36
  • 62.78 (n)
  • 59.22 (a)
bag1 37
  • 59 (a)
OneToOne
Species with no ortholog for BAG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAG1 Gene

ENSEMBL:
Gene Tree for BAG1 (if available)
TreeFam:
Gene Tree for BAG1 (if available)

Paralogs for BAG1 Gene

Pseudogenes.org Pseudogenes for BAG1 Gene

genes like me logo Genes that share paralogs with BAG1: view

No data available for Paralogs for BAG1 Gene

Variants for BAG1 Gene

Sequence variations from dbSNP and Humsavar for BAG1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs474884 -- 33,253,835(+) TTTAT(C/T)TATCT utr-variant-3-prime
rs542912 -- 33,252,785(+) CTCAA(C/G)ACAGT utr-variant-3-prime
rs706115 -- 33,253,607(+) GAGGT(C/G)TTAAC utr-variant-3-prime
rs706116 -- 33,253,739(+) GAGCC(A/C)CAGAA utr-variant-3-prime
rs706117 -- 33,255,745(-) GGTTA(C/T)ATTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAG1 Gene

Variant ID Type Subtype PubMed ID
nsv893017 CNV Gain 21882294
nsv519369 CNV Gain 19592680
esv2463163 CNV Deletion 19546169

Relevant External Links for BAG1 Gene

HapMap Linkage Disequilibrium report
BAG1
Human Gene Mutation Database (HGMD)
BAG1

Disorders for BAG1 Gene

(1) MalaCards Diseases for BAG1 Gene

Search for BAG1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for BAG1 Gene

(26) Novoseek inferred disease relationships for BAG1 Gene

Disease -log(P) Hits PubMed IDs
shock 57.7 20
breast cancer 44.8 54
cancer 35.5 25
tumors 25.4 30
breast carcinoma 24.7 9

Relevant External Links for BAG1

Genetic Association Database (GAD)
BAG1
Human Genome Epidemiology (HuGE) Navigator
BAG1
genes like me logo Genes that share disorders with BAG1: view

No data available for UniProtKB/Swiss-Prot for BAG1 Gene

Publications for BAG1 Gene

  1. Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. (PMID: 7834747) Takayama S. … Reed J.C. (Cell 1995) 2 3 23
  2. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. (PMID: 9305631) Takayama S. … Reed J.C. (EMBO J. 1997) 3 4 23
  3. Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation. (PMID: 9396724) Packham G. … Cleveland J.L. (Biochem. J. 1997) 3 4 23
  4. Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. (PMID: 9679980) Takayama S. … Reed J.C. (Cancer Res. 1998) 3 4 23
  5. p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. (PMID: 9582267) Matsuzawa S. … Reed J.C. (EMBO J. 1998) 3 4 23

Products for BAG1 Gene

Sources for BAG1 Gene

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