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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BAG1 Gene

protein-coding   GIFtS: 63
GCID: GC09M033245

BCL2-Associated Athanogene

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BCL2-Associated Athanogene1 2     Bcl-2 Associating Athanogene-1 Protein2
BAG-12 3     Bcl-2-Binding Protein2
HAP2 3     Glucocortoid Receptor-Associated Protein RAP462
RAP462     Receptor-Associated Protein, 46-KD2
BAG Family Molecular Chaperone Regulator 12     Bcl-2-Associated Athanogene 13

External Ids:    HGNC: 9371   Entrez Gene: 5732   Ensembl: ENSG000001072627   OMIM: 6014975   UniProtKB: Q999333   

Export aliases for BAG1 gene to outside databases

Previous GC identifers: GC09M033567 GC09M033423 GC09M033244


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BAG1 Gene:
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell
death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It
enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and
anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG)
initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined
on chromosome X. (provided by RefSeq, Feb 2010)

GeneCards Summary for BAG1 Gene: 
BAG1 (BCL2-associated athanogene) is a protein-coding gene. Diseases associated with BAG1 include head injury, and narcolepsy. GO annotations related to this gene include receptor signaling protein activity and chaperone binding.

UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933
Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the
pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death
function of BCL2 induced by various stimuli

Gene Wiki entry for BAG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BAG1 gene promoter:
         GR   RFX1   AML1a   AP-1   p53   ATF-2   STAT3   GR-alpha   c-Jun   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BAG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for BAG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p12   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p12

BAG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAG1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M033245:  view genomic region     (about GC identifiers)

Start:
33,247,818 bp from pter      End:
33,264,761 bp from pter
Size:
16,944 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933 (See protein sequence)
Recommended Name: BAG family molecular chaperone regulator 1  
Size: 345 amino acids; 38779 Da
Subunit: Homodimer. Forms a heteromeric complex with HSP70/HSC70. Binds to the ATPase domain of HSP/HSC70
chaperones. Isoform 1, isoform 3 and isoform 4 but not isoform 2 interact with HSPA8/HSC70. Interacts with NR3C1.
Interacts with the N-terminal region of STK19. Interacts with PPP1R15A. Interacts with BCL2 in an ATP-dependent
manner. Isoform 2 does not interact with BCL2
Subcellular location: Isoform 1: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus
Subcellular location: Isoform 2: Cytoplasm. Nucleus. Note=Isoform 2 localizes to the cytoplasm and shuttles into
the nucleus in response to heat shock
Subcellular location: Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The
cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is
also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the
nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria
Sequence caution: Sequence=AAD11467.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAD25045.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD96469.1;
Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG
leucine codon; Sequence=CAA84624.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAH72516.1; Type=Erroneous gene model prediction; Sequence=CAH72518.1; Type=Erroneous gene model
prediction; Sequence=CAH72741.1; Type=Erroneous gene model prediction; Sequence=CAH72742.1; Type=Erroneous gene
model prediction; Sequence=EAW58515.1; Type=Erroneous gene model prediction;
6/9 PDB 3D structures from and Proteopedia for BAG1 (see all 9):
1HX1 (3D)        1WXV (3D)        3FZF (3D)        3FZH (3D)        3FZK (3D)        3FZL (3D)    
Secondary accessions: O75315 Q14414 Q53H32 Q5VZE8 Q5VZE9 Q5VZF0 Q96TG2 Q9Y2V4
Alternative splicing, Alternative initiation: 4 isoforms:  Q99933-1   Q99933-2   Q99933-3   Q99933-4   (Produced by alternative initiation at Met-116 of isoform 1)

Explore the universe of human proteins at neXtProt for BAG1: NX_Q99933

Explore proteomics data for BAG1 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (Probable)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99933

  • BAG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BAG1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001165886.1  NP_004314.5  

    ENSEMBL proteins: 
     ENSP00000369029   ENSP00000369026   ENSP00000419092   ENSP00000417576   ENSP00000420514  

    Human Recombinant Protein Products for BAG1: 
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for BAG1
    Cloud-Clone Corp. Proteins for BAG1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IEA--
    GO:0005829cytosol ----

    BAG1 for ontologies           About GeneDecksing



    BAG1 Antibody Products: 
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    Assay Products for BAG1: 
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    Cloud-Clone Corp. ELISAs for BAG1 
    Cloud-Clone Corp. CLIAs for BAG1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR003103 BAG_domain
     IPR017093 Molecular_chp_reg_BAG_1
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup

    Graphical View of Domain Structure for InterPro Entry Q99933

    ProtoNet protein and cluster: Q99933

    2 Blocks protein domains:
    IPB000626 Ubiquitin domain
    IPB003103 Apoptosis regulator Bcl-2 protein


    UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933
    Similarity: Contains 1 BAG domain
    Similarity: Contains 1 ubiquitin-like domain


    BAG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BAG1_HUMAN, Q99933
    Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the
    pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death
    function of BCL2 induced by various stimuli
    Induction: Up-regulated during differentiation of bladder epithelial cells and down-regulated during
    differentiation of prostate epithelium

         Genatlas biochemistry entry for BAG1:
    BCL2-associated athanogene 1 (antiapoptotic),negative regulator of Hsp70 chaperone activity,multifunctional
    protein interacting with several types of proteins,including BCL2 family proteins,certain tyrosine-kinase
    receptors such as hepatocyte growth factor receptor (MET) and PDGFR and steroid receptors,mouse Bag1 homolog,with
    four isoforms (50,46 (RAP46),33 and 29kDa),overexpressed in cervical,breast (invasive carcinomas) and lung cancer
    cell lines

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity TAS8947043
    GO:0005515protein binding IPI19800331
    GO:0051087chaperone binding IEA--
    GO:0051219phosphoprotein binding ----
         
    BAG1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BAG1:
     Decreased focal adhesion (FA)  

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bag1):
     hematopoietic system  immune system  liver/biliary system  mortality/aging  tumorigenesis 

    BAG1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bag1tm1Msd for BAG1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BAG1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BAG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BAG1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BAG1 

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    SwitchGear 3'UTR luciferase reporter plasmidBAG1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAG1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BAG1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum
    2Androgen receptor signaling pathway
    Androgen receptor signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for BAG1
        Androgen receptor signaling pathway


    1         Kegg Pathway  (Kegg details for BAG1):
        Protein processing in endoplasmic reticulum


    BAG1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BAG1

    5/39 Interacting proteins for BAG1 (Q999332, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081072, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    ENSG00000215328P081072, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    ENSG00000224501P081072, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    ENSG00000231555P081072, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    ENSG00000232804P081072, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007166cell surface receptor signaling pathway TAS8947043
    GO:0030182neuron differentiation ----
    GO:0043066negative regulation of apoptotic process TAS8947043
    GO:0043525positive regulation of neuron apoptotic process ----

    BAG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BAG1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for BAG1

    1 DrugBank Compound for BAG1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol-- --target--10592235

    10/19 Novoseek inferred chemical compound relationships for BAG1 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-(4-hydroxyphenyl)retinamide 52 7 10772821 (6)
    steroid 38.1 23 10567384 (3), 15297164 (1), 17323428 (1), 9305631 (1) (see all 15)
    nocodazole 35.5 1 14532969 (1)
    fludarabine 31.3 4 16501812 (3)
    paclitaxel 30.9 2 15031599 (1), 18006758 (1)
    vincristine 22.7 1 17700523 (1)
    cycloheximide 18.3 3 19151744 (1)
    estrogen 17.8 20 18430249 (3), 15026618 (3), 19151744 (3), 16292491 (2) (see all 7)
    progesterone 16.3 11 18430249 (3), 15026618 (3), 15297164 (1), 12902980 (1) (see all 7)
    atp 13.9 3 9321400 (1), 9305631 (1), 11741305 (1)

    Search CenterWatch for drugs/clinical trials and news about BAG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BAG1 gene (2 alternative transcripts): 
    NM_001172415.1  NM_004323.5  

    Unigene Cluster for BAG1:

    BCL2-associated athanogene
    Hs.377484  [show with all ESTs]
    Unigene Representative Sequence: NM_004323
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493917 ENST00000379701 ENST00000467389 ENST00000379707 ENST00000379704
    ENST00000468274 ENST00000473464 ENST00000473781 ENST00000488499 ENST00000472232(uc003zsi.3 uc003zsj.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AF022224.1 AF116273.1 AK096038.1 AK222749.1 AK316577.1 BC001936.1 BC014774.1 U46917.1 
    Z35491.1 

    17 DOTS entries:

    DT.315269  DT.97839334  DT.100837530  DT.101963542  DT.111920  DT.100837517  DT.100837526  DT.100028750 
    DT.80100284  DT.100837522  DT.95343676  DT.111921  DT.75195442  DT.92407910  DT.95328823  DT.407507 
    DT.92439425 

    24/321 AceView cDNA sequences (see all 321):

    BM980163 CD366964 CA945070 BQ448659 BU685423 BC001936 CR600928 BM968819 
    AI656087 AI924573 CF126150 BQ059093 CR605802 AA649985 BQ673460 BQ416718 
    BU731534 AI400730 BM702786 BQ668479 CR618567 CB306226 CA944441 BM695593 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BAG1    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                          -                 -           -                           
    SP2:                                                                                    
    SP3:                                            -                                       
    SP4:                                                                                    
    SP5:                    -     -                                                         


    ECgene alternative splicing isoforms for BAG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BAG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATTGGGA
    BAG1 Expression
    About this image


    See BAG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BAG1

    SOURCE GeneReport for Unigene cluster: Hs.377484

    UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933
    Tissue specificity: Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout
    most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and
    testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia
    and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the
    least abundant isoform in tumor cell lines (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including BAG1: 
              p53 Signaling Pathway in human mouse rat
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              Heat Shock Proteins & Chaperones in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BAG1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bag11 , 5 BCL2-associated athanogene 11, 5 81.64(n)1
    73.33(a)1
      4 (20.67 cM)5
    120171  NM_009736.31  NP_033866.41 
     409363985 
    chicken
    (Gallus gallus)
    Aves BAG11 BCL2-associated athanogene 71.24(n)
    69.61(a)
      420967  NM_001109692.1  NP_001103162.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.191392 Xenopus laevis transcribed sequence with weak similarity more 74.99(n)    AW640566.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bag11 BCL2-associated athanogene 1 62.78(n)
    59.22(a)
      558108  NM_001098736.1  NP_001092206.1 
    worm
    (Caenorhabditis elegans)
    Secernentea bag-16
    BAG family molecular chaperone regulator 1
    23(a)
    1 ↔ 1
    I(6563640-6564453)


    ENSEMBL Gene Tree for BAG1 (if available)
    TreeFam Gene Tree for BAG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BAG1 gene

    BAG1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for BAG1
    PGOHUM00000237190 PGOHUM00000241714


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/342 SNPs in BAG1 are shown (see all 342)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38343871,2
    C--33220815(-) AGGCA-/TATATT 2 -- int10--------
    rs1476021691,2
    --33221481(+) CTCACG/TGGAGA 2 -- ds50010--------
    rs1422809821,2
    --33221496(+) TTTCAA/CAGGCA 2 -- ds50010--------
    rs1882900391,2
    --33221527(+) ATCTGC/TGTGGG 2 -- ds50010--------
    rs625426901,2
    C--33221694(+) TGTGTG/ACATTC 2 -- ds50014Minor allele frequency- A:0.12NA WA EA 360
    rs603204291,2
    C,F--33221745(+) ATATAC/TAAGAC 2 -- ut311Minor allele frequency- T:0.01WA 118
    rs1390700351,2
    C--33221794(+) TATGT-/TATA  
            
    TATAT
    2 -- ut310--------
    rs1121373871,2
    F--33221874(+) AAGAAG/ACTCCT 2 -- ut312Minor allele frequency- A:0.50CSA 4
    rs1460768391,2
    C--33221905(+) TTAAAC/GGCAAA 2 -- ut310--------
    rs5429121,2
    C,F,A--33222022(+) CTCAAC/GACAGT 2 -- ut319Minor allele frequency- G:0.16MN NA CSA WA EA 552

    HapMap Linkage Disequilibrium report for BAG1 (33247818 - 33264761 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BAG1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2463163CNV Deletion19546169
    nsv519369CNV Gain19592680
    nsv893017CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601497    OMIM disorders: --

    20/44 diseases for BAG1 (see all 44):    About MalaCards
    head injury    narcolepsy    toxoplasmosis    laryngeal carcinoma
    laryngeal squamous cell carcinoma    leukoplakia    cervical cancer    laryngitis
    retinoblastoma    cervicitis    oral squamous cell carcinoma    diffuse large b-cell lymphoma
    squamous cell carcinoma    kaposi's sarcoma    b-cell lymphomas    esophageal cancer
    esophagitis    esophageal squamous cell carcinoma    malignant glioma    peritonitis

    1 disease from the University of Copenhagen DISEASES database for BAG1:
    Spindle cell hemangioma

    BAG1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/26 Novoseek inferred disease relationships for BAG1 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 57.7 25 11494137 (2), 12558971 (2), 15003494 (2), 12874020 (2) (see all 15)
    breast cancer 44.8 75 10576663 (5), 11181661 (5), 15026618 (4), 19151744 (4) (see all 24)
    cancer 35.5 34 12373595 (5), 10772821 (2), 15297164 (2), 15033003 (2) (see all 16)
    tumors 25.4 36 18795671 (3), 10467399 (3), 18430249 (2), 11494232 (2) (see all 20)
    breast carcinoma 24.7 9 10561207 (4), 15026618 (2), 19243896 (2), 19066611 (1)
    carcinoma 22.9 30 17549665 (5), 20096920 (4), 16457154 (3), 19620938 (2) (see all 11)
    metastasis 20.1 18 17657847 (3), 19620938 (2), 10964051 (1), 20096920 (1) (see all 10)
    cervical carcinoma 18.1 5 10772821 (2), 10047462 (2), 12370827 (1)
    colon carcinoma 17 8 17657847 (8)
    adenoma 15 14 12845674 (4), 20096920 (2), 16042572 (2), 15560850 (2) (see all 5)

    Genetic Association Database (GAD): BAG1
    Human Genome Epidemiology (HuGE) Navigator: BAG1 (9 documents)

    Export disorders for BAG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BAG1 gene, integrated from 9 sources (see all 241):
    (articles sorted by number of sources associating them with BAG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. (PubMed id 9679980)1, 2, 9 Takayama S.... Reed J.C. (1998)
    2. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. (PubMed id 9305631)1, 2, 9 Takayama S.... Reed J.C. (1997)
    3. Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation. (PubMed id 9396724)1, 2, 9 Packham G.... Cleveland J.L. (1997)
    4. p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. (PubMed id 9582267)1, 2, 9 Matsuzawa S.... Reed J.C. (1998)
    5. Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. (PubMed id 7834747)1, 3, 9 Takayama S....Reed J.C. (1995)
    6. Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. (PubMed id 12724406)1, 2, 9 Hung W.J.... Wu D.Y. (2003)
    7. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PubMed id 9873016)1, 2, 9 Takayama S.... Reed J.C. (1999)
    8. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. Germline variation in apoptosis pathway genes and ris k of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 573 HGNC: 937 AceView: BAG1 Ensembl:ENSG00000107262 euGenes: HUgn573
    ECgene: BAG1 Kegg: 573 H-InvDB: BAG1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BAG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BAG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BAG1 gene:
    Search GeneIP for patents involving BAG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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