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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BAG1 Gene

protein-coding   GIFtS: 63
GCID: GC09M033245

BCL2-associated athanogene
 Explore 53 diseases affiliated with
BAG1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BAG1    

Aliases
for BAG1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
BCL2-Associated Athanogene1 2     Bcl-2 Associating Athanogene-1 Protein2
BAG-12 3     Bcl-2-Binding Protein2
HAP2 3     Glucocortoid Receptor-Associated Protein RAP462
RAP462     Receptor-Associated Protein, 46-KD2
BAG Family Molecular Chaperone Regulator 12     Bcl-2-Associated Athanogene 13

External Ids:    HGNC: 9371   Entrez Gene: 5732   Ensembl: ENSG000001072627   OMIM: 6014975   UniProtKB: Q999333   

Export aliases for BAG1 gene to outside databases

Previous GC identifers: GC09M033567 GC09M033423 GC09M033244


Summaries
for BAG1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BAG1:
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death.
The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the
anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms.
Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three
alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. (provided by
RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933
Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic
function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced
by various stimuli

Gene Wiki entry for BAG1


Genomic Views
for BAG1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BAG1 gene promoter:
         GR   RFX1   AML1a   AP-1   p53   ATF-2   STAT3   GR-alpha   c-Jun   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BAG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for BAG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p12   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p12

BAG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAG1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M033245:  view genomic region     (about GC identifiers)

Start:
 33,247,818 bp from pter      End:
 33,264,761 bp from pter
Size:
 16,944 bases      Orientation:
 minus strand

Proteins
for BAG1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933 (See protein sequence)
Recommended Name: BAG family molecular chaperone regulator 1  
Size: 345 amino acids; 38779 Da
Subunit: Homodimer. Forms a heteromeric complex with HSP70/HSC70. Binds to the ATPase domain of HSP/HSC70 chaperones.
Isoform 1, isoform 3 and isoform 4 but not isoform 2 interact with HSPA8/HSC70. Interacts with NR3C1. Interacts with
the N-terminal region of STK19. Interacts with PPP1R15A. Interacts with BCL2 in an ATP-dependent manner. Isoform 2
does not interact with BCL2
Subcellular location: Isoform 1: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus
Subcellular location: Isoform 2: Cytoplasm. Nucleus. Note=Isoform 2 localizes to the cytoplasm and shuttles into the
nucleus in response to heat shock
Subcellular location: Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The
cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also
found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear
envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria
Sequence caution: Sequence=AAD11467.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAD25045.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD96469.1;
Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG
leucine codon; Sequence=CAA84624.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAH72516.1; Type=Erroneous gene model prediction; Sequence=CAH72518.1; Type=Erroneous gene model prediction;
Sequence=CAH72741.1; Type=Erroneous gene model prediction; Sequence=CAH72742.1; Type=Erroneous gene model prediction;
Sequence=EAW58515.1; Type=Erroneous gene model prediction;
6/9 PDB 3D structures from and Proteopedia for BAG1 (see all 9):
1HX1 (3D)        1WXV (3D)        3FZF (3D)        3FZH (3D)        3FZK (3D)        3FZL (3D)    
Secondary accessions: O75315 Q14414 Q53H32 Q5VZE8 Q5VZE9 Q5VZF0 Q96TG2 Q9Y2V4
Alternative splicing, Alternative initiation: 4 isoforms:  Q99933-1   Q99933-2   Q99933-3   Q99933-4   (Produced by alternative initiation at Met-116 of isoform 1)

Explore the universe of human proteins at neXtProt for BAG1: NX_Q99933

Post-translational modifications:

  • Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (Probable)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99933

    • BAG1 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins (2 alternative transcripts): 
    NP_001165886.1  NP_004314.5  

    ENSEMBL proteins: 
     ENSP00000369022   ENSP00000369029   ENSP00000369026   ENSP00000419092   ENSP00000417576  
     ENSP00000420514  

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    Uscn Proteins for BAG1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IEA--
    GO:0005739mitochondrion ----
    GO:0005829cytosol ----
    GO:0045111intermediate filament cytoskeleton ----


    BAG1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for BAG1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BAG1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003103 BAG_domain
     IPR017093 Molecular_chp_reg_BAG_1
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup

    Graphical View of Domain Structure for InterPro Entry Q99933

    ProtoNet protein and cluster: Q99933

    2 Blocks protein families:
    IPB000626 Ubiquitin domain
    IPB003103 Apoptosis regulator Bcl-2 protein


    UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933
    Similarity: Contains 1 BAG domain
    Similarity: Contains 1 ubiquitin-like domain


    Function
    for BAG1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933
    Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic
    function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced
    by various stimuli
    Induction: Up-regulated during differentiation of bladder epithelial cells and down-regulated during differentiation of
    prostate epithelium

         Genatlas biochemistry entry for BAG1:
    BCL2-associated athanogene 1 (antiapoptotic),negative regulator of Hsp70 chaperone activity,multifunctional protein
    interacting with several types of proteins,including BCL2 family proteins,certain tyrosine-kinase receptors such as
    hepatocyte growth factor receptor (MET) and PDGFR and steroid receptors,mouse Bag1 homolog,with four isoforms (50,46
    (RAP46),33 and 29kDa),overexpressed in cervical,breast (invasive carcinomas) and lung cancer cell lines

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity TAS8947043
    GO:0005515protein binding IPI9305631
    GO:0051087chaperone binding IEA--
    GO:0051219phosphoprotein binding ----


    BAG1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for BAG1:
     Decreased focal adhesion (FA)  

    Animal Models:
         Mouse knock-out Bag1tm1Msd for BAG1
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Bag1):
     hematopoietic system  immune system  liver/biliary system  mortality/aging  tumorigenesis 

    BAG1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BAG1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Protein processing in endoplasmic reticulum
    		Protein processing in endoplasmic reticulum1.00
    2Androgen receptor signaling pathway
    		Androgen receptor signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for BAG1 
        Androgen receptor signaling pathway


    1         Kegg Pathway  (Kegg details for BAG1):
        Protein processing in endoplasmic reticulum


    BAG1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BAG1

    5/31 Interacting proteins for BAG1 (Q999332, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA8P111422, 3MINT-7265483 MINT-7265269 MINT-7265281 MINT-7265310 MINT-7265364 MINT-7265296 MINT-7265351 MINT-7265464 MINT-7265324 MINT-7265339 I2D: score=4 
    HSPA1AP081072, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    HSPA1BP081072, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    RAF1P040492, 3MINT-45862 MINT-45863 I2D: score=3 
    ST13P505022, 3MINT-45857 MINT-45858 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0006950response to stress ----
    GO:0007166cell surface receptor signaling pathway TAS8947043
    GO:0010226response to lithium ion ----
    GO:0014070response to organic cyclic compound ----


    BAG1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BAG1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BAG1 for compounds           About GeneDecksing

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    Browse Tocris compounds for BAG1

    1 DrugBank Compound for BAG1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol-- --target--10592235

    10/19 Novoseek chemical compound relationships for BAG1 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-(4-hydroxyphenyl)retinamide 52 7 10772821 (6)
    steroid 38.1 23 10567384 (3), 15297164 (1), 17323428 (1), 9305631 (1) (see all 15)
    nocodazole 35.5 1 14532969 (1)
    fludarabine 31.3 4 16501812 (3)
    paclitaxel 30.9 2 15031599 (1), 18006758 (1)
    vincristine 22.7 1 17700523 (1)
    cycloheximide 18.3 3 19151744 (1)
    estrogen 17.8 20 18430249 (3), 15026618 (3), 19151744 (3), 16292491 (2) (see all 7)
    progesterone 16.3 11 18430249 (3), 15026618 (3), 15297164 (1), 12902980 (1) (see all 7)
    atp 13.9 3 9321400 (1), 9305631 (1), 11741305 (1)

    Search CenterWatch for drugs/clinical trials and news about BAG1 

    Transcripts
    for BAG1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BAG1 gene (2 alternative transcripts): 
    NM_001172415.1  NM_004323.5  

    Unigene Cluster for BAG1:

    BCL2-associated athanogene
    Hs.377484  [show with all ESTs]
    Unigene Representative Sequence: NM_004323
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493917 ENST00000379701 ENST00000379700 ENST00000379707 ENST00000379704
    ENST00000468274 ENST00000473464 ENST00000473781 ENST00000467389 ENST00000488499
    ENST00000472232(uc003zsi.3 uc003zsj.3)

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    hsa-miR-146a hsa-miR-4299 hsa-miR-520a-5p hsa-miR-570 hsa-miR-515-5p hsa-miR-483-3p hsa-miR-1252 hsa-miR-580
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF022224.1 AF116273.1 AK096038.1 AK222749.1 AK316577.1 BC001936.1 BC014774.1 U46917.1 
    Z35491.1 

    17 DOTS entries:

    DT.315269  DT.97839334  DT.100837530  DT.101963542  DT.111920  DT.100837517  DT.100837526  DT.100028750 
    DT.80100284  DT.100837522  DT.95343676  DT.111921  DT.75195442  DT.92407910  DT.95328823  DT.407507 
    DT.92439425 

    24/321 AceView cDNA sequences (see all 321):

    BQ231865 AA649985 AI656087 BQ017480 BC001936 BQ669503 CA440174 BM980163 
    BQ416718 BM768501 Z35491 CR618366 BM978241 BU731534 AI922890 CR618567 
    BE858027 BM699480 BM924910 CR605802 BM702786 AI924567 BM971376 BQ673460 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BAG1    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                          -                 -           -                           
    SP2:                                                                                    
    SP3:                                            -                                       
    SP4:                                                                                    
    SP5:                    -     -                                                         


    ECgene alternative splicing isoforms for BAG1

    Expression
    for BAG1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BAG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAATTGGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    Genevestigator expression for BAG1

    SOURCE GeneReport for Unigene cluster: Hs.377484

    UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933
    Tissue specificity: Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most
    tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis.
    Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma
    cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant
    isoform in tumor cell lines (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including BAG1: 
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              Apoptosis in human mouse rat
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    Orthologs
    for BAG1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for BAG1 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Bag11 , 5 BCL2-associated athanogene 11, 5 81.64(n)1
    73.33(a)1    		   4 (20.67 cM)5
    120171  NM_009736.31  NP_033866.41 
     409363985 
    chicken
    (Gallus gallus)    		 Aves BAG11 BCL2-associated athanogene 71.24(n)
    69.61(a)    		   420967  NM_001109692.1  NP_001103162.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.191392 Xenopus laevis transcribed sequence with weak similarity more 74.99(n)    AW640566.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii bag11 BCL2-associated athanogene 1 62.78(n)
    59.22(a)    		   558108  NM_001098736.1  NP_001092206.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea bag-16
    		 BAG family molecular chaperone regulator 1
    		 24(a)
    		 1 ↔ 1
    		 I(6563641-6564454)


    ENSEMBL Gene Tree for BAG1 (if available)
    TreeFam Gene Tree for BAG1 (if available) 

    Paralogs
    for BAG1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BAG1 gene

    BAG1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for BAG1
    PGOHUM00000237190 PGOHUM00000241714


    Genomic Variants
    for BAG1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/260 NCBI SNPs in BAG1 are shown (see all 260)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs603204291,2
    		C,--33209407(+) ATATAC/TAAGAC 2 -- ut311Minor allele frequency- T:0.01WA 118
    rs1121373871,2
    		F--33209540(+) AAGAAG/ACTCCT 2 -- ut312Minor allele frequency- A:0.50CSA 4
    rs169191251,2
    		C,F,H,--33209708(+) TTCTCC/AATGCA 2 -- ut3112Minor allele frequency- A:0.03NA NS EA WA 1526
    rs793488381,2
    		F,--33209846(+) AGGGTG/ACAGTG 2 -- ut313Minor allele frequency- A:0.14CSA WA 122
    rs7061161,2
    		H--33210642(+) GAGCCA/CCAGAA 2 -- ut315Minor allele frequency- C:0.00MN NS EA 600
    rs600838391,2
    		C,--33210683(+) AAAAGG/CAAACC 2 -- ut311Minor allele frequency- C:0.50WA 2
    rs734766521,2
    		C,--33210864(+) GGAAGG/AAGCTA 2 -- ut311Minor allele frequency- A:0.50WA 2
    rs121564471,2
    		C,F--33211075(+) AAGCAG/AAATGG 2 -- ut31 ese33Minor allele frequency- A:0.33NA 6
    rs756911331,2
    		F,--33211370(+) TCATTC/GTGGTG 2 -- ut311Minor allele frequency- G:0.07WA 118
    rs169191291,2
    		C,F,H,--33211580(+) TAGAAC/ACCAAC 2 -- ut31 ese315Minor allele frequency- A:0.09NA NS EA CSA WA 1526

    HapMap Linkage Disequilibrium report for BAG1 (33247818 - 33264761 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for BAG1
         1 CNV: 100626

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    Disorders / Diseases
    for BAG1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BAG1 for disorders           About GeneDecksing

    OMIM gene information: 601497    OMIM disorders: --

    20/53 diseases for BAG1 (see all 53):    About MalaCards
    diffuse large b-cell lymphoma    b-cell lymphomas    non-hodgkin lymphoma    squamous cell carcinoma
    leukemia/lymphoma    laryngeal squamous cell carcinoma    oral squamous cell carcinoma    esophageal squamous cell carcinoma
    leukemia/lymphoma, t-cell    hodgkin's lymphoma    head injury    chronic lymphocytic leukemia
    epithelial ovarian cancer    lymphocytic leukemia    kaposi's sarcoma    laryngitis
    malignant glioma    carcinoma    leukoplakia    cervicitis

    10/26 Novoseek disease relationships for BAG1 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 57.7 25 11494137 (2), 12558971 (2), 15003494 (2), 12874020 (2) (see all 15)
    breast cancer 44.8 75 10576663 (5), 11181661 (5), 15026618 (4), 19151744 (4) (see all 24)
    cancer 35.5 34 12373595 (5), 10772821 (2), 15297164 (2), 15033003 (2) (see all 16)
    tumors 25.4 36 18795671 (3), 10467399 (3), 18430249 (2), 11494232 (2) (see all 20)
    breast carcinoma 24.7 9 10561207 (4), 15026618 (2), 19243896 (2), 19066611 (1)
    carcinoma 22.9 30 17549665 (5), 20096920 (4), 16457154 (3), 19620938 (2) (see all 11)
    metastasis 20.1 18 17657847 (3), 19620938 (2), 10964051 (1), 20096920 (1) (see all 10)
    cervical carcinoma 18.1 5 10772821 (2), 10047462 (2), 12370827 (1)
    colon carcinoma 17 8 17657847 (8)
    adenoma 15 14 12845674 (4), 20096920 (2), 16042572 (2), 15560850 (2) (see all 5)

    Genetic Association Database (GAD): BAG1
    Human Genome Epidemiology (HuGE) Navigator: BAG1 (9 documents)

    Export disorders for BAG1 gene to outside databases

    Publications
    for BAG1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BAG1 gene, integrated from 9 sources (see all 230):
    (articles sorted by number of sources associating them with BAG1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. (PubMed id 9679980)1, 2, 9 Takayama S.... Reed J.C. (1998)
    2. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. (PubMed id 9305631)1, 2, 9 Takayama S.... Reed J.C. (1997)
    3. Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation. (PubMed id 9396724)1, 2, 9 Packham G.... Cleveland J.L. (1997)
    4. p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. (PubMed id 9582267)1, 2, 9 Matsuzawa S.... Reed J.C. (1998)
    5. Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. (PubMed id 7834747)1, 3, 9 Takayama S....Reed J.C. (1995)
    6. Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. (PubMed id 12724406)1, 2, 9 Hung W.J.... Wu D.Y. (2003)
    7. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PubMed id 9873016)1, 2, 9 Takayama S.... Reed J.C. (1999)
    8. Characterization of Hap/BAG-1 variants as RP1 binding proteins with antiapoptotic activity. (PubMed id 15986447)1, 2 Wadle A.... Renner C. (2005)
    9. Screening for candidate gene regions in narcolepsy using a microsatellite based approach and pooled DNA. (PubMed id 15309313)1, 4 Wieczorek S....Epplen J.T. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for BAG1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing BAG1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 573 HGNC: 937 AceView: BAG1 Ensembl:ENSG00000107262 euGenes: HUgn573
    ECgene: BAG1 Kegg: 573 H-InvDB: BAG1

    Other Databases showing BAG1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BAG1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BAG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BAG1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for BAG1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BAG1 gene:
    Search GeneIP for patents involving BAG1

    GeneCards and IP:
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