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BAG1 Gene

protein-coding   GIFtS: 65
GCID: GC09M033245

BCL2-Associated Athanogene

  See BAG1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
BCL2-Associated Athanogene1 2     Bcl-2 Associating Athanogene-1 Protein2
BAG-12 3     Bcl-2-Binding Protein2
HAP2 3     Glucocortoid Receptor-Associated Protein RAP462
RAP462     Receptor-Associated Protein, 46-KD2
BAG Family Molecular Chaperone Regulator 12     Bcl-2-Associated Athanogene 13

External Ids:    HGNC: 9371   Entrez Gene: 5732   Ensembl: ENSG000001072627   OMIM: 6014975   UniProtKB: Q999333   
ORGUL members:         

Export aliases for BAG1 gene to outside databases

Previous GC identifers: GC09M033567 GC09M033423 GC09M033244


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BAG1 Gene:
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell
death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It
enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and
anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG)
initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined
on chromosome X. (provided by RefSeq, Feb 2010)

GeneCards Summary for BAG1 Gene:
BAG1 (BCL2-associated athanogene) is a protein-coding gene. Diseases associated with BAG1 include spindle cell hemangioma. GO annotations related to this gene include receptor signaling protein activity and chaperone binding.

UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933
Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the
pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death
function of BCL2 induced by various stimuli

Gene Wiki entry for BAG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the BAG1 gene promoter:
         GR   RFX1   AML1a   AP-1   p53   ATF-2   STAT3   GR-alpha   c-Jun   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BAG1 promoter sequence
   Search Chromatin IP Primers for BAG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BAG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p12   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p12

BAG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAG1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M033245:  view genomic region     (about GC identifiers)

Start:
33,247,818 bp from pter      End:
33,264,761 bp from pter
Size:
16,944 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933 (See protein sequence)
Recommended Name: BAG family molecular chaperone regulator 1  
Size: 345 amino acids; 38779 Da
Subunit: Homodimer. Forms a heteromeric complex with HSP70/HSC70. Binds to the ATPase domain of HSP/HSC70
chaperones. Isoform 1, isoform 3 and isoform 4 but not isoform 2 interact with HSPA8/HSC70. Interacts with NR3C1.
Interacts with the N-terminal region of STK19. Interacts with PPP1R15A. Interacts with BCL2 in an ATP-dependent
manner. Isoform 2 does not interact with BCL2
Sequence caution: Sequence=AAD11467.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAD25045.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD96469.1;
Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG
leucine codon; Sequence=CAA84624.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAH72516.1; Type=Erroneous gene model prediction; Sequence=CAH72518.1; Type=Erroneous gene model
prediction; Sequence=CAH72741.1; Type=Erroneous gene model prediction; Sequence=CAH72742.1; Type=Erroneous gene
model prediction; Sequence=EAW58515.1; Type=Erroneous gene model prediction;
Selected PDB 3D structures from and Proteopedia for BAG1 (see all 9):
1HX1 (3D)        1WXV (3D)        3FZF (3D)        3FZH (3D)        3FZK (3D)        3FZL (3D)    
Secondary accessions: O75315 Q14414 Q53H32 Q5VZE8 Q5VZE9 Q5VZF0 Q96TG2 Q9Y2V4
Alternative splicing, Alternative initiation: 4 isoforms:  Q99933-1   Q99933-2   Q99933-3   Q99933-4   (Produced by alternative initiation at Met-116 of isoform 1)

Explore the universe of human proteins at neXtProt for BAG1: NX_Q99933

Explore proteomics data for BAG1 at MOPED

Post-translational modifications: 

  • Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (Probable)1
  • Ubiquitination2 at Lys273
  • Modification sites at PhosphoSitePlus

  • See BAG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001165886.1  NP_004314.5  

    ENSEMBL proteins: 
     ENSP00000369029   ENSP00000369026   ENSP00000419092   ENSP00000417576   ENSP00000420514  

    BAG1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for BAG1
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    Novus Biologicals BAG1 Proteins
    Novus Biologicals BAG1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for BAG1
    Cloud-Clone Corp. Proteins for BAG1

     
    Search eBioscience for Proteins for BAG1 

    BAG1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BAG1
    R&D Systems Antibodies for BAG1 (Bag-1)
    Cell Signaling Technology (CST) Antibodies for BAG1 
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    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BAG1
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    Search eBioscience for ELISAs for BAG1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR003103 BAG_domain
     IPR000626 Ubiquitin_dom
     IPR017093 Molecular_chp_reg_BAG_1

    Graphical View of Domain Structure for InterPro Entry Q99933

    ProtoNet protein and cluster: Q99933

    2 Blocks protein domains:
    IPB000626 Ubiquitin domain
    IPB003103 Apoptosis regulator Bcl-2 protein


    UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933
    Similarity: Contains 1 BAG domain
    Similarity: Contains 1 ubiquitin-like domain


    Find genes that share domains with BAG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BAG1_HUMAN, Q99933
    Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the
    pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death
    function of BCL2 induced by various stimuli
    Induction: Up-regulated during differentiation of bladder epithelial cells and down-regulated during
    differentiation of prostate epithelium

         Genatlas biochemistry entry for BAG1:
    BCL2-associated athanogene 1 (antiapoptotic),negative regulator of Hsp70 chaperone activity,multifunctional
    protein interacting with several types of proteins,including BCL2 family proteins,certain tyrosine-kinase
    receptors such as hepatocyte growth factor receptor (MET) and PDGFR and steroid receptors,mouse Bag1 homolog,with
    four isoforms (50,46 (RAP46),33 and 29kDa),overexpressed in cervical,breast (invasive carcinomas) and lung cancer
    cell lines

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity TAS8947043
    GO:0005515protein binding IPI19800331
    GO:0051087chaperone binding IEA--
    GO:0051219phosphoprotein binding ----
         
    Find genes that share ontologies with BAG1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BAG1:
     Decreased focal adhesion (FA)  

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bag1):
     hematopoietic system  immune system  liver/biliary system  mortality/aging  tumorigenesis 

    Find genes that share phenotypes with BAG1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bag1tm1Msd for BAG1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BAG1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BAG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BAG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BAG1

    miRNA
    Products:
        
    miRTarBase miRNAs that target BAG1:
    hsa-mir-182-5p (MIRT047188)

    Block miRNA regulation of human, mouse, rat BAG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BAG1 (see all 20):
    hsa-miR-146a hsa-miR-4299 hsa-miR-520a-5p hsa-miR-570 hsa-miR-515-5p hsa-miR-483-3p hsa-miR-1252 hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmidBAG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BAG1
    Predesigned siRNA for gene silencing in human, mouse, rat BAG1

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): BAG1 (NM_004323)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BAG1_HUMAN, Q99933: Isoform 1: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus
    BAG1_HUMAN, Q99933: Isoform 2: Cytoplasm. Nucleus. Note=Isoform 2 localizes to the cytoplasm and shuttles into
    the nucleus in response to heat shock
    BAG1_HUMAN, Q99933: Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The
    cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is
    also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the
    nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2
    endoplasmic reticulum1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IEA--
    GO:0005829cytosol ----

    Find genes that share ontologies with BAG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BAG1 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum
    2Androgen receptor signaling pathway
    Androgen receptor signaling pathway


    Find genes that share SuperPaths with BAG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for BAG1
        Androgen receptor signaling pathway


    1 Kegg Pathway  (Kegg details for BAG1):
        Protein processing in endoplasmic reticulum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BAG1: 
              p53 Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BAG1

    Selected Interacting proteins for BAG1 (Q999331, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA8P111421, 2, 3EBI-1030678,EBI-351896 MINT-7265483 MINT-7265269 MINT-7265281 MINT-7265310 MINT-7265364 MINT-7265296 MINT-7265351 MINT-7265464 MINT-7265324 MINT-7265339 I2D: score=4 
    ENSG00000212866P081072, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    ENSG00000215328P081072, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    ENSG00000224501P081072, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    ENSG00000231555P081072, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007166cell surface receptor signaling pathway TAS8947043
    GO:0030182neuron differentiation ----
    GO:0035556intracellular signal transduction TAS8947043
    GO:0043066negative regulation of apoptotic process TAS8947043

    Find genes that share ontologies with BAG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for BAG1 (see all 19)     About this table
    CompoundAction CAS #
    2,3-DCPE hydrochlorideSelectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro[418788-90-6]
    ABT-199Selective Bcl-2 inhibitor[1257044-40-8]
    ABT-263 (Navitoclax)orally sellecitive inhibitor of Bcl-2 family proteins[923564-51-6]
    ABT-737novel and potent inhibitor of BCL-2 family proteins[852808-04-9]
    Apogossypolone (ApoG2)pan Bcl-2 inhibitor[886578-07-0]
    AT-101R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1[90141-22-3]
    Bax channel blockerPotent inhibitor of Bax-mediated mitochondrial cytochrome c release[335165-68-9]
    Bax inhibitor peptide P5Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria[579492-83-4]
    Bax inhibitor peptide V5Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria[579492-81-2]
    Bax inhibitor peptide, negative controlNegative control peptide for the Bax inhibitor peptides V5 and P5[1315378-74-5]

    Browse Tocris compounds for BAG1

    1 DrugBank Compound for BAG1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for BAG1 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-(4-hydroxyphenyl)retinamide 52 7 10772821 (6)
    steroid 38.1 23 10567384 (3), 15297164 (1), 17323428 (1), 9305631 (1) (see all 15)
    nocodazole 35.5 1 14532969 (1)
    fludarabine 31.3 4 16501812 (3)
    paclitaxel 30.9 2 15031599 (1), 18006758 (1)
    vincristine 22.7 1 17700523 (1)
    cycloheximide 18.3 3 19151744 (1)
    estrogen 17.8 20 18430249 (3), 15026618 (3), 19151744 (3), 16292491 (2) (see all 7)
    progesterone 16.3 11 18430249 (3), 15026618 (3), 15297164 (1), 12902980 (1) (see all 7)
    atp 13.9 3 9321400 (1), 9305631 (1), 11741305 (1)



    Find genes that share compounds with BAG1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BAG1 gene (2 alternative transcripts): 
    NM_001172415.1  NM_004323.5  

    Unigene Cluster for BAG1:

    BCL2-associated athanogene
    Hs.377484  [show with all ESTs]
    Unigene Representative Sequence: NM_004323
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493917 ENST00000379701 ENST00000467389 ENST00000379707 ENST00000379704
    ENST00000468274 ENST00000473464 ENST00000473781 ENST00000488499 ENST00000472232(uc003zsi.3 uc003zsj.3)

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    hsa-miR-146a hsa-miR-4299 hsa-miR-520a-5p hsa-miR-570 hsa-miR-515-5p hsa-miR-483-3p hsa-miR-1252 hsa-miR-580
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAG1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat BAG1
      QuantiFast Probe-based Assays in human, mouse, rat BAG1

    Additional mRNA sequence: 

    AF022224.1 AF116273.1 AK096038.1 AK222749.1 AK316577.1 BC001936.1 BC014774.1 U46917.1 
    Z35491.1 

    17 DOTS entries:

    DT.315269  DT.97839334  DT.100837530  DT.101963542  DT.111920  DT.100837517  DT.100837526  DT.100028750 
    DT.80100284  DT.100837522  DT.95343676  DT.111921  DT.75195442  DT.92407910  DT.95328823  DT.407507 
    DT.92439425 

    Selected AceView cDNA sequences (see all 321):

    BQ448659 CB120889 BQ017480 BM968819 CR618366 CK429751 BM924910 BM980163 
    AW769375 CF126150 CR605802 BM978241 AA027283 CR603873 BQ231865 BQ059093 
    AW206941 Z35491 CB529642 BU731534 BC014774 BM971376 CB305892 BM699480 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BAG1    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                          -                 -           -                           
    SP2:                                                                                    
    SP3:                                            -                                       
    SP4:                                                                                    
    SP5:                    -     -                                                         


    ECgene alternative splicing isoforms for BAG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BAG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATTGGGA
    BAG1 Expression
    About this image


    BAG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Thyroid (Endocrine System)
     
     Lung (Respiratory System)
    BAG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BAG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.377484

    UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933
    Tissue specificity: Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout
    most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and
    testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia
    and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the
    least abundant isoform in tumor cell lines (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BAG1: 
              p53 Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BAG1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bag11 , 5 BCL2-associated athanogene 11, 5 81.64(n)1
    73.62(a)1
      4 (20.67 cM)5
    120171  NM_009736.31  NP_033866.41 
     409363985 
    chicken
    (Gallus gallus)
    Aves BAG11 BCL2-associated athanogene 71.66(n)
    69.57(a)
      420967  NM_001109692.1  NP_001103162.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.191392 Xenopus laevis transcribed sequence with weak similarity more 74.99(n)    AW640566.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bag11 BCL2-associated athanogene 1 62.78(n)
    59.22(a)
      558108  NM_001098736.1  NP_001092206.1 


    ENSEMBL Gene Tree for BAG1 (if available)
    TreeFam Gene Tree for BAG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BAG1 gene

    Find genes that share paralogs with BAG1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for BAG1
    PGOHUM00000237190 PGOHUM00000241714


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BAG1 (see all 342)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38343871,2
    C--33220815(-) AGGCA-/TATATT 2 -- int10--------
    rs1476021691,2
    --33221481(+) CTCACG/TGGAGA 2 -- ds50010--------
    rs1422809821,2
    --33221496(+) TTTCAA/CAGGCA 2 -- ds50010--------
    rs1882900391,2
    --33221527(+) ATCTGC/TGTGGG 2 -- ds50010--------
    rs625426901,2
    C--33221694(+) TGTGTG/ACATTC 2 -- ds50014Minor allele frequency- A:0.12NA WA EA 360
    rs603204291,2
    C,F--33221745(+) ATATAC/TAAGAC 2 -- ut311Minor allele frequency- T:0.01WA 118
    rs1390700351,2
    C--33221794(+) TATGT-/TATA  
            
    TATAT
    2 -- ut310--------
    rs1121373871,2
    F--33221874(+) AAGAAG/ACTCCT 2 -- ut312Minor allele frequency- A:0.50CSA 4
    rs1460768391,2
    C--33221905(+) TTAAAC/GGCAAA 2 -- ut310--------
    rs5429121,2
    C,F,A--33222022(+) CTCAAC/GACAGT 2 -- ut319Minor allele frequency- G:0.16MN NA CSA WA EA 552

    HapMap Linkage Disequilibrium report for BAG1 (33247818 - 33264761 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BAG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2463163CNV Deletion19546169
    nsv519369CNV Gain19592680
    nsv893017CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BAG1
    DNA2.0 Custom Variant and Variant Library Synthesis for BAG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601497    OMIM disorders: --

    1 disease for BAG1:    
    About MalaCards
    spindle cell hemangioma

    1 disease from the University of Copenhagen DISEASES database for BAG1:
    Spindle cell hemangioma

    Find genes that share disorders with BAG1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BAG1 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 57.7 25 11494137 (2), 12558971 (2), 15003494 (2), 12874020 (2) (see all 15)
    breast cancer 44.8 75 10576663 (5), 11181661 (5), 15026618 (4), 19151744 (4) (see all 24)
    cancer 35.5 34 12373595 (5), 10772821 (2), 15297164 (2), 15033003 (2) (see all 16)
    tumors 25.4 36 18795671 (3), 10467399 (3), 18430249 (2), 11494232 (2) (see all 20)
    breast carcinoma 24.7 9 10561207 (4), 15026618 (2), 19243896 (2), 19066611 (1)
    carcinoma 22.9 30 17549665 (5), 20096920 (4), 16457154 (3), 19620938 (2) (see all 11)
    metastasis 20.1 18 17657847 (3), 19620938 (2), 10964051 (1), 20096920 (1) (see all 10)
    cervical carcinoma 18.1 5 10772821 (2), 10047462 (2), 12370827 (1)
    colon carcinoma 17 8 17657847 (8)
    adenoma 15 14 12845674 (4), 20096920 (2), 16042572 (2), 15560850 (2) (see all 5)

    Genetic Association Database (GAD): BAG1
    Human Genome Epidemiology (HuGE) Navigator: BAG1 (9 documents)

    Export disorders for BAG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BAG1 gene, integrated from 10 sources (see all 248):
    (articles sorted by number of sources associating them with BAG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. (PubMed id 9679980)1, 2, 9 Takayama S.... Reed J.C. (Cancer Res. 1998)
    2. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. (PubMed id 9305631)1, 2, 9 Takayama S.... Reed J.C. (EMBO J. 1997)
    3. Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation. (PubMed id 9396724)1, 2, 9 Packham G.... Cleveland J.L. (Biochem. J. 1997)
    4. p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. (PubMed id 9582267)1, 2, 9 Matsuzawa S.... Reed J.C. (EMBO J. 1998)
    5. Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. (PubMed id 7834747)1, 3, 9 Takayama S....Reed J.C. (Cell 1995)
    6. Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. (PubMed id 12724406)1, 2, 9 Hung W.J.... Wu D.Y. (Mol. Cell. Biol. 2003)
    7. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PubMed id 9873016)1, 2, 9 Takayama S.... Reed J.C. (J. Biol. Chem. 1999)
    8. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 573 HGNC: 937 AceView: BAG1 Ensembl:ENSG00000107262 euGenes: HUgn573
    ECgene: BAG1 Kegg: 573 H-InvDB: BAG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BAG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BAG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BAG1 gene:
    Search GeneIP for patents involving BAG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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