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Aliases for BAD Gene

Aliases for BAD Gene

  • BCL2 Associated Agonist Of Cell Death 2 3 5
  • Bcl-XL/Bcl-2-Associated Death Promoter 3 4
  • Bcl2 Antagonist Of Cell Death 3 4
  • Bcl-2-Binding Component 6 3 4
  • Bcl-2-Like Protein 8 3 4
  • Bcl2-L-8 3 4
  • BCL2L8 3 4
  • BCL2-Antagonist Of Cell Death Protein 3
  • Bcl2-Associated Agonist Of Cell Death 3
  • BCL-X/BCL-2 Binding Protein 3
  • BCL2-Binding Component 6 3
  • BCL2-Binding Protein 3
  • BBC2 3
  • BBC6 4

External Ids for BAD Gene

Previous GeneCards Identifiers for BAD Gene

  • GC11M066553
  • GC11M065718
  • GC11M063812
  • GC11M063793
  • GC11M064037
  • GC11M060365

Summaries for BAD Gene

Entrez Gene Summary for BAD Gene

  • The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAD Gene

BAD (BCL2 Associated Agonist Of Cell Death) is a Protein Coding gene. Diseases associated with BAD include Adrenal Cortical Adenocarcinoma and Endometrial Cancer. Among its related pathways are Development IGF-1 receptor signaling and Constitutive Signaling by AKT1 E17K in Cancer. GO annotations related to this gene include protein heterodimerization activity and lipid binding.

UniProtKB/Swiss-Prot for BAD Gene

  • Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

Gene Wiki entry for BAD Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAD Gene

Genomics for BAD Gene

Regulatory Elements for BAD Gene

Enhancers for BAD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G064320 1.4 Ensembl ENCODE dbSUPER 12.1 -38.4 -38416 5.3 HDAC1 KLF17 NFXL1 RAD21 ZNF366 EGR1 SCRT2 EGR2 ZNF263 ZBTB2 PLCB3 LOC102723878 ENSG00000257086 CATSPERZ ENSG00000207024 KCNK4-TEX40 KCNK4 BAD GPR137 TRMT112
GH11G064237 1.4 ENCODE dbSUPER 11.6 +39.4 39386 16.6 CREB3L1 MLX AGO1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC ENSG00000257086 TRMT112 TRPT1 ZFPL1 PPP1R14B LOC102723878 VEGFB KCNK4 PLCB3 FERMT3
GH11G064205 1.4 ENCODE dbSUPER 11.5 +77.1 77109 4.4 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZFPL1 TRPT1 ENSG00000257086 PLCB3 TRMT112 GPR137 BAD KCNK4-TEX40 KCNK4 ENSG00000207024
GH11G064204 0.9 ENCODE 11.3 +80.0 80021 1.2 HDGF ATF1 ARNT SIN3A ZNF2 ZNF143 DEK ZNF263 REST ZNF592 TRPT1 NUDT22 DNAJC4 ENSG00000257086 PLCB3 MACROD1 GPR137 BAD FERMT3 GC11M064182
GH11G064347 0.8 ENCODE 11.5 -63.7 -63678 1.9 BCOR KLF1 JUN CHD4 ZMYM3 MAX CEBPG ZNF366 POLR2A FOXK2 LOC102723878 MIR1237 PRDX5 TRMT112 ESRRA CATSPERZ ENSG00000207024 KCNK4 KCNK4-TEX40 BAD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BAD on UCSC Golden Path with GeneCards custom track

Promoters for BAD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040643 -496 2001 HDGF HNRNPUL1 PKNOX1 AGO1 ARID4B SIN3A YY1 SLC30A9 ZNF766 ZNF143

Genomic Location for BAD Gene

Chromosome:
11
Start:
64,269,828 bp from pter
End:
64,284,704 bp from pter
Size:
14,877 bases
Orientation:
Minus strand

Genomic View for BAD Gene

Genes around BAD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAD Gene

Proteins for BAD Gene

  • Protein details for BAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92934-BAD_HUMAN
    Recommended name:
    Bcl2-associated agonist of cell death
    Protein Accession:
    Q92934
    Secondary Accessions:
    • O14803
    • Q6FH21

    Protein attributes for BAD Gene

    Size:
    168 amino acids
    Molecular mass:
    18392 Da
    Quaternary structure:
    • Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity). The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins (By similarity). Interacts with AKT1 and PIM3. Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BAD with BCL2 (By similarity). Interacts with HIF3A (via C-terminus domain); the interaction reduces the binding between BAD and BAX (By similarity).
    SequenceCaution:
    • Sequence=AAB36516.1; Type=Frameshift; Positions=64, 91; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BAD Gene

neXtProt entry for BAD Gene

Post-translational modifications for BAD Gene

  • Methylation at Arg-94 and Arg-96 by PRMT1 inhibits Akt-mediated phosphorylation at Ser-99.
  • Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blocked by the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity during apoptosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BAD Gene

No data available for DME Specific Peptides for BAD Gene

Domains & Families for BAD Gene

Gene Families for BAD Gene

Protein Domains for BAD Gene

Graphical View of Domain Structure for InterPro Entry

Q92934

UniProtKB/Swiss-Prot:

BAD_HUMAN :
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
  • Belongs to the Bcl-2 family.
Domain:
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BAD: view

Function for BAD Gene

Molecular function for BAD Gene

UniProtKB/Swiss-Prot Function:
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

Gene Ontology (GO) - Molecular Function for BAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9388232
GO:0005543 phospholipid binding IMP 21081150
GO:0008289 lipid binding IDA 19667065
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IDA 18402937
GO:0019901 protein kinase binding IPI 17270021
genes like me logo Genes that share ontologies with BAD: view
genes like me logo Genes that share phenotypes with BAD: view

Animal Models for BAD Gene

MGI Knock Outs for BAD:

Animal Model Products

CRISPR Products

miRNA for BAD Gene

miRTarBase miRNAs that target BAD

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BAD

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BAD Gene

Localization for BAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAD Gene

Mitochondrion outer membrane. Cytoplasm. Note=Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm. {ECO:0000250 UniProtKB:Q61337}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BAD gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for BAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA,IEA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with BAD: view

Pathways & Interactions for BAD Gene

genes like me logo Genes that share pathways with BAD: view

Pathways by source for BAD Gene

SIGNOR curated interactions for BAD Gene

Gene Ontology (GO) - Biological Process for BAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001836 release of cytochrome c from mitochondria IEA --
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS --
GO:0006007 glucose catabolic process IEA --
GO:0006915 apoptotic process IEA,TAS 7834748
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS --
genes like me logo Genes that share ontologies with BAD: view

Drugs & Compounds for BAD Gene

(38) Drugs for BAD Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ABT-263 Investigational Pharma Target 0
AT-101 Pharma inhibitor BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors 0
ABT-263 (Navitoclax) Pharma Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w 0
Bax inhibitor peptide P5 Pharma Bax inhibitor 0
Bax inhibitor peptide V5 Pharma Bax inhibitor 0

(14) Additional Compounds for BAD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(6) ApexBio Compounds for BAD Gene

Compound Action Cas Number
ABT-263 (Navitoclax) Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w 923564-51-6
AT-101 BH3-mimetic,gossypol enantiomer 90141-22-3
Bax inhibitor peptide P5 Bax inhibitor 579492-83-4
Bax inhibitor peptide V5 Bax inhibitor 579492-81-2
Gossypol PAF inhibitor;anti-fertility and anti-cancer 303-45-7
Sabutoclax pan-Bcl-2 inhibitor 1228108-65-3
genes like me logo Genes that share compounds with BAD: view

Drug Products

Transcripts for BAD Gene

Unigene Clusters for BAD Gene

BCL2-associated agonist of cell death:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BAD

Alternative Splicing Database (ASD) splice patterns (SP) for BAD Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5:
SP6: - - - -

Relevant External Links for BAD Gene

GeneLoc Exon Structure for
BAD
ECgene alternative splicing isoforms for
BAD

Expression for BAD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BAD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BAD Gene

This gene is overexpressed in Bone (14.8) and Skin (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BAD Gene



NURSA nuclear receptor signaling pathways regulating expression of BAD Gene:

BAD

SOURCE GeneReport for Unigene cluster for BAD Gene:

Hs.370254

mRNA Expression by UniProt/SwissProt for BAD Gene:

Q92934-BAD_HUMAN
Tissue specificity: Expressed in a wide variety of tissues.

Evidence on tissue expression from TISSUES for BAD Gene

  • Lung(4.4)
  • Muscle(4.3)
  • Bone marrow(4.2)
  • Liver(4.2)
  • Eye(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with BAD: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAD Gene

Orthologs for BAD Gene

This gene was present in the common ancestor of chordates.

Orthologs for BAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAD 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia BAD 34 35
  • 86.35 (n)
cow
(Bos Taurus)
Mammalia BAD 34 35
  • 85.03 (n)
mouse
(Mus musculus)
Mammalia Bad 34 16 35
  • 82.92 (n)
rat
(Rattus norvegicus)
Mammalia Bad 34
  • 82.3 (n)
zebrafish
(Danio rerio)
Actinopterygii badb 35
  • 39 (a)
OneToMany
bada 35
  • 34 (a)
OneToMany
Species where no ortholog for BAD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAD Gene

ENSEMBL:
Gene Tree for BAD (if available)
TreeFam:
Gene Tree for BAD (if available)

Paralogs for BAD Gene

No data available for Paralogs for BAD Gene

Variants for BAD Gene

Sequence variations from dbSNP and Humsavar for BAD Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000009542 -- 64,272,887(+) GCCCT(C/G)ACTCC intron-variant
rs1000679595 -- 64,276,575(+) AAGTG(C/T)CTCGG intron-variant
rs1000873868 -- 64,270,016(+) AAAAC(A/C)CAAAA upstream-variant-2KB, utr-variant-3-prime
rs1000999174 -- 64,286,294(+) GAGAC(G/T)GCCCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001012410 -- 64,273,643(+) TGGGA(A/G)GCCGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAD Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv2744615 CNV deletion 23290073
esv2744616 CNV deletion 23290073
nsv1159904 CNV deletion 26073780
nsv357 CNV insertion 18451855
nsv469961 CNV loss 18288195
nsv555184 CNV loss 21841781
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for BAD Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BAD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BAD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAD Gene

Disorders for BAD Gene

MalaCards: The human disease database

(5) MalaCards diseases for BAD Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adrenal cortical adenocarcinoma
  • adrenocortical carcinoma
endometrial cancer
  • endometrial cancer, familial
prostate cancer
  • prostate cancer, hereditary, 5
pharyngoconjunctival fever
  • adenoviral pharyngoconjunctivitis
alzheimer's disease 14
  • ad14
- elite association - COSMIC cancer census association via MalaCards
Search BAD in MalaCards View complete list of genes associated with diseases

Relevant External Links for BAD

Genetic Association Database (GAD)
BAD
Human Genome Epidemiology (HuGE) Navigator
BAD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BAD
genes like me logo Genes that share disorders with BAD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BAD Gene

Publications for BAD Gene

  1. Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. (PMID: 9388232) Ottilie S. … Oltersdorf T. (J. Biol. Chem. 1997) 3 4 22 64
  2. Bcl-2 targets the protein kinase Raf-1 to mitochondria. (PMID: 8929532) Wang H.-G. … Reed J.C. (Cell 1996) 2 3 4 64
  3. A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. (PMID: 22423221) Qayyum R. … Reiner A.P. (PLoS Genet. 2012) 3 46 64
  4. Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt. (PMID: 21444773) Sakamaki J. … Fukamizu A. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for BAD Gene

  • Addgene plasmids for BAD

Sources for BAD Gene

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