Aliases for BAD Gene
Aliases for BAD Gene
External Ids for BAD Gene
- HGNC: 936
- Entrez Gene: 572
- Ensembl: ENSG00000002330
- OMIM: 603167
- UniProtKB: Q92934
Previous GeneCards Identifiers for BAD Gene
- GC11M066553
- GC11M065718
- GC11M063812
- GC11M063793
- GC11M064037
- GC11M060365
Summaries for BAD Gene
-
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]
GeneCards Summary for BAD Gene
BAD (BCL2 Associated Agonist Of Cell Death) is a Protein Coding gene. Diseases associated with BAD include Adrenal Cortical Adenocarcinoma and Endometrial Cancer. Among its related pathways are Development IGF-1 receptor signaling and Constitutive Signaling by AKT1 E17K in Cancer. GO annotations related to this gene include protein heterodimerization activity and lipid binding.
UniProtKB/Swiss-Prot for BAD Gene
-
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAD Gene
Genomics for BAD Gene
Regulatory Elements for BAD Gene
Enhancers for BAD Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around BAD on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the BAD gene promoter:
Regulatory Element Products
Genomic Location for BAD Gene
- Chromosome:
- 11
- Start:
- 64,269,828 bp from pter
- End:
- 64,284,704 bp from pter
- Size:
- 14,877 bases
- Orientation:
- Minus strand
Genomic View for BAD Gene
Genes around BAD on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
BAD Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BAD Gene
Proteins for BAD Gene
-
Protein details for BAD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92934-BAD_HUMAN
- Recommended name:
- Bcl2-associated agonist of cell death
- Protein Accession:
- Q92934
- O14803
- Q6FH21
Protein attributes for BAD Gene
- Size:
- 168 amino acids
- Molecular mass:
- 18392 Da
- Quaternary structure:
-
- Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity). The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins (By similarity). Interacts with AKT1 and PIM3. Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BAD with BCL2 (By similarity). Interacts with HIF3A (via C-terminus domain); the interaction reduces the binding between BAD and BAX (By similarity).
- SequenceCaution:
-
- Sequence=AAB36516.1; Type=Frameshift; Positions=64, 91; Evidence={ECO:0000305};
Protein Expression for BAD Gene
Post-translational modifications for BAD Gene
- Methylation at Arg-94 and Arg-96 by PRMT1 inhibits Akt-mediated phosphorylation at Ser-99.
- Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blocked by the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity during apoptosis.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for BAD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for BAD
- R&D Systems Antibodies for BAD (Bad)
- Cell Signaling Technology (CST) Antibodies for BAD (BAD)
-
Custom Antibody ServicesOriGene Antibodies for BAD
- AM00008PU-N
- AP00013PU-N
- AP00083PU-N
- AP01534PU-N
- AP01535PU-N
- AP01734PU-N
- AP02366PU-N
- AP02366PU-S
- AP02603PU-N
- AP02603PU-S
- AP02604PU-N
- AP02604PU-S
- AP02605PU-N
- AP02605PU-S
- AP02799PU-N
- AP02799PU-S
- AP06025PU-N
- AP06401PU-N
- AP07170PU-N
- AP07676PU-N
- AP12570PU-N
- AP20193PU-N
- AP20292PU-N
- AP20876PU-N
- AP20966PU-N
- AP55717PU-N
- AP55717PU-S
- TA300475
- TA306174
- TA309965
- TA309966
- TA309967
- TA312433
- TA312434
- TA312435
- TA312437
- TA312438
- TA312439
- TA312440
- TA322769
- TA322770
- TA324511
- TA324514
- TA324762
- TA324763
- TA324764
- TA325251
- TA325252
- TA325253
- TA325254
- TA336427
- TA590290
- TA349219
- Novus Biologicals Antibodies for BAD
-
Cloud-Clone Corp. Antibodies for BAD
- Invitrogen Antibodies for BAD
- antibodies-online Antibodies for BAD: See all 973
- GeneTex BAD antibody for BAD
-
Custom Antibody ServicesProSci Antibodies for BAD
-
Santa Cruz Biotechnology (SCBT) Antibodies for BAD
Protein Products
- EMD Millipore Purified and/or Recombinant BAD Protein
- Search Origene for MassSpec and Protein Over-expression Lysates for BAD
- Origene Custom Protein Services for BAD
- ProSpec Recombinant Proteins for BAD
-
Cloud-Clone Corp. Proteins for BAD
- antibodies-online Proteins for BAD: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for BAD
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for BAD (Bad)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for BAD (BAD)
- antibodies-online Kits for BAD: See all 49
No data available for DME Specific Peptides for BAD Gene
Domains & Families for BAD Gene
Gene Families for BAD Gene
Protein Domains for BAD Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for BAD Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92934UniProtKB/Swiss-Prot:
BAD_HUMAN :- Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
- Belongs to the Bcl-2 family.
- Domain:
-
- Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
- Family:
-
- Belongs to the Bcl-2 family.
Function for BAD Gene
Molecular function for BAD Gene
- UniProtKB/Swiss-Prot Function:
- Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 9388232 |
| GO:0005543 | phospholipid binding | IMP | 21081150 |
| GO:0008289 | lipid binding | IDA | 19667065 |
| GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process | IDA | 18402937 |
| GO:0019901 | protein kinase binding | IPI | 17270021 |
Phenotypes for BAD Gene
- MGI mutant phenotypes for BAD:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for BAD:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased ionizing radiation sensitivity
- Dynamic nuclei (hole, folded or small irregular)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Synthetic lethal with imatinib mesylate
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased viability with nutlin-3
Animal Models for BAD Gene
- MGI Knock Outs for BAD:
-
- Bad tm1Sjk
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BAD
-
-
ViGene Biosciences lentiviral particle packaged cDNA for BAD gene
- Search ViGene Biosciences for BAD
CRISPR Products
-
OriGene CRISPR knockouts for BAD
-
Santa Cruz Biotechnology (SCBT) CRISPR for BAD
- GenScript: Design CRISPR guide RNA sequences for BAD
miRNA for BAD Gene
- miRTarBase miRNAs that target BAD
miRNA Products
- Search ViGene Biosciences for BAD
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for BAD
- Browse OriGene Inhibitory RNA Products For BAD
- Search ViGene Biosciences for BAD
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for BAD
- VectorBuilder custom plasmid, inducible vectors for BAD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for BAD
-
ViGene Biosciences adenoviral particle packaged cDNA for BAD gene
-
ViGene Biosciences lentiviral particle packaged cDNA for BAD gene
- Search ViGene Biosciences for BAD
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12158) for BAD
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BAD Gene
Localization for BAD Gene
Subcellular locations from UniProtKB/Swiss-Prot for BAD Gene
- Mitochondrion outer membrane. Cytoplasm. Note=Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm. {ECO:0000250 UniProtKB:Q61337}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| cytosol | 5 |
| nucleus | 2 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IDA,IEA | -- |
| GO:0005741 | mitochondrial outer membrane | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for BAD Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways | ||
| 3 | Glioma |
.41
|
.37
|
| 4 | Development HGF signaling pathway | ||
| 5 | GAB1 signalosome |
.89
|
|
Pathways by source for BAD Gene
2 Sino Biological pathways for BAD Gene
2 GeneTex pathways for BAD Gene
3 Cell Signaling Technology pathways for BAD Gene
32 BioSystems pathways for BAD Gene
33 Reactome pathways for BAD Gene
1 PharmGKB pathway for BAD Gene
31 KEGG pathways for BAD Gene
15 GeneGo (Thomson Reuters) pathways for BAD Gene
12 R&D Systems pathways for BAD Gene
1 Tocris pathway for BAD Gene
Interacting Proteins for BAD Gene
Selected Interacting proteins:
ENSP00000309103
Q92934-BAD_HUMAN
for BAD Gene via
STRING
MINT
UniProtKB
IID
SIGNOR curated interactions for BAD Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001836 | release of cytochrome c from mitochondria | IEA | -- |
| GO:0001844 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | TAS | -- |
| GO:0006007 | glucose catabolic process | IEA | -- |
| GO:0006915 | apoptotic process | IEA,TAS | 7834748 |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | ISS | -- |
Drugs & Compounds for BAD Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| ABT-263 | Investigational | Pharma | Target | 0 | ||
| AT-101 | Pharma | inhibitor | BH3-mimetic,gossypol enantiomer, BCL-2 inhibitors | 0 | ||
| ABT-263 (Navitoclax) | Pharma | Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w | 0 | |||
| Bax inhibitor peptide P5 | Pharma | Bax inhibitor | 0 | |||
| Bax inhibitor peptide V5 | Pharma | Bax inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(6) ApexBio Compounds for BAD Gene
| Compound | Action | Cas Number |
|---|---|---|
| ABT-263 (Navitoclax) | Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w | 923564-51-6 |
| AT-101 | BH3-mimetic,gossypol enantiomer | 90141-22-3 |
| Bax inhibitor peptide P5 | Bax inhibitor | 579492-83-4 |
| Bax inhibitor peptide V5 | Bax inhibitor | 579492-81-2 |
| Gossypol | PAF inhibitor;anti-fertility and anti-cancer | 303-45-7 |
| Sabutoclax | pan-Bcl-2 inhibitor | 1228108-65-3 |
Drug Products
- ApexBio compounds for BAD
Transcripts for BAD Gene
mRNA/cDNA for BAD Gene
- (2) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (240) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for BAD Gene
CRISPR Products
-
OriGene CRISPR knockouts for BAD
-
Santa Cruz Biotechnology (SCBT) CRISPR for BAD
- GenScript: Design CRISPR guide RNA sequences for BAD
miRNA Products
- Search ViGene Biosciences for BAD
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for BAD
- Browse OriGene Inhibitory RNA Products For BAD
- Search ViGene Biosciences for BAD
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for BAD
- VectorBuilder custom plasmid, inducible vectors for BAD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12158) for BAD
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||
| SP6: | - | - | - | - |
Expression for BAD Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Bone (14.8) and Skin (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BAD Gene
NURSA nuclear receptor signaling pathways regulating expression of BAD Gene:
BADSOURCE GeneReport for Unigene cluster for BAD Gene:
Hs.370254mRNA Expression by UniProt/SwissProt for BAD Gene:
Q92934-BAD_HUMAN
Tissue specificity:
Expressed in a wide variety of tissues.
Evidence on tissue expression from TISSUES for BAD Gene
- Lung(4.4)
- Muscle(4.3)
- Bone marrow(4.2)
- Liver(4.2)
- Eye(2.1)
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs for BAD
-
OriGene qPCR primer pairs and template standards for BAD
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAD Gene
Orthologs for BAD Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BAD 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | BAD 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | BAD 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Bad 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bad 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | badb 35 |
|
OneToMany | |
| bada 35 |
|
OneToMany |
- Species where no ortholog for BAD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for BAD Gene
No data available for Paralogs for BAD Gene
Variants for BAD Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000009542 | -- | 64,272,887(+) | GCCCT(C/G)ACTCC | intron-variant | |
| rs1000679595 | -- | 64,276,575(+) | AAGTG(C/T)CTCGG | intron-variant | |
| rs1000873868 | -- | 64,270,016(+) | AAAAC(A/C)CAAAA | upstream-variant-2KB, utr-variant-3-prime | |
| rs1000999174 | -- | 64,286,294(+) | GAGAC(G/T)GCCCT | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1001012410 | -- | 64,273,643(+) | TGGGA(A/G)GCCGA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1963n54 | CNV | loss | 21841781 |
| esv2744615 | CNV | deletion | 23290073 |
| esv2744616 | CNV | deletion | 23290073 |
| nsv1159904 | CNV | deletion | 26073780 |
| nsv357 | CNV | insertion | 18451855 |
| nsv469961 | CNV | loss | 18288195 |
| nsv555184 | CNV | loss | 21841781 |
| nsv832186 | CNV | loss | 17160897 |
| nsv951010 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.38;
8.29% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for BAD Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BAD
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAD Gene
Disorders for BAD Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| adrenal cortical adenocarcinoma |
|
|
| endometrial cancer |
|
|
| prostate cancer |
|
|
| pharyngoconjunctival fever |
|
|
| alzheimer's disease 14 |
|
|
Search BAD in MalaCards
View complete list of genes associated with diseases
Relevant External Links for BAD
No data available for UniProtKB/Swiss-Prot and Genatlas for BAD Gene
Publications for BAD Gene
- Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. (PMID: 9388232) Ottilie S. … Oltersdorf T. (J. Biol. Chem. 1997) 3 4 22 64
- Bcl-2 targets the protein kinase Raf-1 to mitochondria. (PMID: 8929532) Wang H.-G. … Reed J.C. (Cell 1996) 2 3 4 64
- A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. (PMID: 22423221) Qayyum R. … Reiner A.P. (PLoS Genet. 2012) 3 46 64
- Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt. (PMID: 21444773) Sakamaki J. … Fukamizu A. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
Products for BAD Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for BAD
- EMD Millipore Purified and/or Recombinant BAD Protein
- Browse Kits and Assays available from EMD Millipore
- EMD Millipore genomic analysis products
- R&D Systems Antibodies for BAD (Bad)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for BAD (Bad)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for BAD
- AM00008PU-N
- AP00013PU-N
- AP00083PU-N
- AP01534PU-N
- AP01535PU-N
- AP01734PU-N
- AP02366PU-N
- AP02366PU-S
- AP02603PU-N
- AP02603PU-S
- AP02604PU-N
- AP02604PU-S
- AP02605PU-N
- AP02605PU-S
- AP02799PU-N
- AP02799PU-S
- AP06025PU-N
- AP06401PU-N
- AP07170PU-N
- AP07676PU-N
- AP12570PU-N
- AP20193PU-N
- AP20292PU-N
- AP20876PU-N
- AP20966PU-N
- AP55717PU-N
- AP55717PU-S
- TA300475
- TA306174
- TA309965
- TA309966
- TA309967
- TA312433
- TA312434
- TA312435
- TA312437
- TA312438
- TA312439
- TA312440
- TA322769
- TA322770
- TA324511
- TA324514
- TA324762
- TA324763
- TA324764
- TA325251
- TA325252
- TA325253
- TA325254
- TA336427
- TA349219
- TA590290
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for BAD
- Origene Custom Protein Services for BAD
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for BAD
- Browse OriGene Inhibitory RNA Products For BAD
- OriGene qPCR primer pairs and template standards for BAD
- OriGene qPCR primer pairs for BAD
- OriGene CRISPR knockouts for BAD
- OriGene ORF clones in human for BAD
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BAD
- GenScript: Next-day shipping cDNA ORF clone for BAD in any vector
- GenScript Custom Purified and Recombinant Proteins Services for BAD
- GenScript Custom Assay Services for BAD
- GenScript Custom overexpressing Cell Line Services for BAD
- GenScript: Design CRISPR guide RNA sequences for BAD
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for BAD
- Cell Signaling Technology (CST) Antibodies for BAD (BAD)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for BAD (BAD)
- Search for Antibodies & Assays
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for BAD
- Novus Biologicals proteins and lysates for BAD
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for BAD
- Cloud-Clone Corp. Antibodies for BAD
- Cloud-Clone Corp. Proteins for BAD
- Browse Assay Kits at Cloud-Clone Corp.
- Invitrogen Antibodies for BAD
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for BAD
- Addgene plasmids for BAD
- antibodies-online Antibodies for BAD: See all 973
- antibodies-online Kits for BAD: See all 49
- antibodies-online Proteins for BAD: See all 8
- Search antibodies-online for peptides
- GeneTex BAD antibody for BAD
- Search GeneTex for Proteins for BAD
- ViGene Biosciences adenoviral particle packaged cDNA for BAD gene
- ViGene Biosciences lentiviral particle packaged cDNA for BAD gene
- Search ViGene Biosciences for BAD
- Santa Cruz Biotechnology (SCBT) Antibodies for BAD
- Search Santa Cruz Biotechnology (SCBT) for BAD siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BAD
- Custom Antibody ServicesProSci Antibodies for BAD
- Search for BAD Proteins at ProSci
- Horizon Cell Lines for BAD
- Cyagen custom Knockout/knockin (KOKI) mouse models for BAD
- VectorBuilder custom plasmid, inducible vectors for BAD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BAD
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for BAD Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer