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Aliases for BAD Gene

Aliases for BAD Gene

  • BCL2-Associated Agonist Of Cell Death 2 3
  • BCL2L8 3 4 6
  • Bcl-XL/Bcl-2-Associated Death Promoter 3 4
  • Bcl2 Antagonist Of Cell Death 3 4
  • Bcl-2-Binding Component 6 3 4
  • Bcl-2-Like Protein 8 3 4
  • Bcl2-L-8 3 4
  • BCL2-Antagonist Of Cell Death Protein 3
  • BCL-X/BCL-2 Binding Protein 3
  • BCL2-Binding Component 6 3
  • BCL2-Binding Protein 3
  • BBC2 3
  • BBC6 4

External Ids for BAD Gene

Previous GeneCards Identifiers for BAD Gene

  • GC11M066553
  • GC11M065718
  • GC11M063812
  • GC11M063793
  • GC11M064037
  • GC11M060365

Summaries for BAD Gene

Entrez Gene Summary for BAD Gene

  • The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAD Gene

BAD (BCL2-Associated Agonist Of Cell Death) is a Protein Coding gene. Diseases associated with BAD include endometrial cancer and pancreatic cancer. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include protein heterodimerization activity and protein kinase binding.

UniProtKB/Swiss-Prot for BAD Gene

  • Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

Gene Wiki entry for BAD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAD Gene

Genomics for BAD Gene

Regulatory Elements for BAD Gene

Genomic Location for BAD Gene

Start:
64,269,828 bp from pter
End:
64,284,704 bp from pter
Size:
14,877 bases
Orientation:
Minus strand

Genomic View for BAD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAD Gene

Proteins for BAD Gene

  • Protein details for BAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92934-BAD_HUMAN
    Recommended name:
    Bcl2-associated agonist of cell death
    Protein Accession:
    Q92934
    Secondary Accessions:
    • O14803
    • Q6FH21

    Protein attributes for BAD Gene

    Size:
    168 amino acids
    Molecular mass:
    18392 Da
    Quaternary structure:
    • Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity). The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins (By similarity). Interacts with AKT1 and PIM3. Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BAD with BCL2 (By similarity). Interacts with HIF3A (via C-terminus domain); the interaction reduces the binding between BAD and BAX (By similarity).
    SequenceCaution:
    • Sequence=AAB36516.1; Type=Frameshift; Positions=64, 91; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BAD Gene

neXtProt entry for BAD Gene

Proteomics data for BAD Gene at MOPED

Post-translational modifications for BAD Gene

  • Methylation at Arg-94 and Arg-96 by PRMT1 inhibits Akt-mediated phosphorylation at Ser-99.
  • Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blocked by the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity during apoptosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BAD Gene

No data available for DME Specific Peptides for BAD Gene

Domains for BAD Gene

Protein Domains for BAD Gene

Graphical View of Domain Structure for InterPro Entry

Q92934

UniProtKB/Swiss-Prot:

BAD_HUMAN :
  • Q92934
Domain:
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BAD: view

No data available for Gene Families for BAD Gene

Function for BAD Gene

Molecular function for BAD Gene

UniProtKB/Swiss-Prot Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

Gene Ontology (GO) - Molecular Function for BAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10949025
GO:0005543 phospholipid binding IMP 21081150
GO:0008289 lipid binding IDA 19667065
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IDA 18402937
GO:0019901 protein kinase binding IPI 17270021
genes like me logo Genes that share ontologies with BAD: view
genes like me logo Genes that share phenotypes with BAD: view

Animal Models for BAD Gene

MGI Knock Outs for BAD:

miRNA for BAD Gene

miRTarBase miRNAs that target BAD

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BAD Gene

Localization for BAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAD Gene

Mitochondrion outer membrane. Cytoplasm. Note=Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm. {ECO:0000250 UniProtKB:Q61337}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAD Gene COMPARTMENTS Subcellular localization image for BAD gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 2
endosome 1
extracellular 1

Gene Ontology (GO) - Cellular Components for BAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with BAD: view

Pathways for BAD Gene

SuperPathways for BAD Gene

Superpath Contained pathways
1 PI-3K cascade
2 Signaling by FGFR
3 IL-9 Signaling Pathways
4 Development HGF signaling pathway
5 Activation of cAMP-Dependent PKA
genes like me logo Genes that share pathways with BAD: view

Gene Ontology (GO) - Biological Process for BAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia --
GO:0001836 release of cytochrome c from mitochondria IEA --
GO:0006007 glucose catabolic process IEA --
GO:0006915 apoptotic process TAS 7834748
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS --
genes like me logo Genes that share ontologies with BAD: view

Compounds for BAD Gene

(19) ApexBio Compounds for BAD Gene

Compound Action Cas Number
2,3-DCPE hydrochloride Selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. [418788-90-6]
ABT-199 Selective Bcl-2 inhibitor [1257044-40-8]
ABT-263 (Navitoclax) orally sellecitive inhibitor of Bcl-2 family proteins [923564-51-6]
ABT-737 novel and potent inhibitor of BCL-2 family proteins [852808-04-9]
Apogossypolone (ApoG2) pan Bcl-2 inhibitor [886578-07-0]
AT-101 R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 [90141-22-3]
Bax channel blocker Potent inhibitor of Bax-mediated mitochondrial cytochrome c release. [335165-68-9]
Bax inhibitor peptide P5 Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria [579492-83-4]
Bax inhibitor peptide V5 Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria [579492-81-2]
Bax inhibitor peptide, negative control Negative control peptide for the Bax inhibitor peptides V5 and P5 [1315378-74-5]
BM-1074 potent and efficacious Bcl-2/Bcl-xL inhibitor [1391108-10-3]
Gambogic Acid activates caspases with EC50 of 0.78-1.64 uM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 [2752-65-0]
HA14-1 non-peptidic ligand of a Bcl-2 [65673-63-4]
Marinopyrrole A novel and specific Mcl-1 inhibitor [1227962-62-0]
MIM1 Inhibitor of Mcl-1
Obatoclax mesylate (GX15-070) potently inhibits BCL-2 family [803712-79-0]
Sabutoclax pan-Bcl-2 inhibitor [1228108-65-3]
TW-37 potent small-molecule inhibitor of BCL-2 [877877-35-5]
WEHI-539 high affinity (subnanomolar) and selectivity for BCL-XL [1431866-33-9]

(45) Novoseek inferred chemical compound relationships for BAD Gene

Compound -log(P) Hits PubMed IDs
ly294002 67.5 10
phosphatidylinositol 62.5 11
wortmannin 62.2 7
pd 98,059 54.6 5
threonine 48.8 2
genes like me logo Genes that share compounds with BAD: view

Transcripts for BAD Gene

Unigene Clusters for BAD Gene

BCL2-associated agonist of cell death:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BAD Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: - -
SP3: -
SP4: - - -
SP5:
SP6: - - - -

Relevant External Links for BAD Gene

GeneLoc Exon Structure for
BAD
ECgene alternative splicing isoforms for
BAD

Expression for BAD Gene

mRNA expression in normal human tissues for BAD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAD Gene

SOURCE GeneReport for Unigene cluster for BAD Gene Hs.370254

mRNA Expression by UniProt/SwissProt for BAD Gene

Q92934-BAD_HUMAN
Tissue specificity: Expressed in a wide variety of tissues
genes like me logo Genes that share expressions with BAD: view

No data available for mRNA differential expression in normal tissues for BAD Gene

Orthologs for BAD Gene

This gene was present in the common ancestor of chordates.

Orthologs for BAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAD 35
  • 99.8 (n)
  • 100 (a)
BAD 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAD 35
  • 85.03 (n)
  • 76.65 (a)
BAD 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAD 35
  • 86.35 (n)
  • 81.33 (a)
BAD 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bad 35
  • 82.92 (n)
  • 77.78 (a)
Bad 16
Bad 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bad 35
  • 82.3 (n)
  • 78.4 (a)
zebrafish
(Danio rerio)
Actinopterygii bada 36
  • 34 (a)
OneToMany
badb 36
  • 39 (a)
OneToMany
Species with no ortholog for BAD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAD Gene

ENSEMBL:
Gene Tree for BAD (if available)
TreeFam:
Gene Tree for BAD (if available)

Paralogs for BAD Gene

No data available for Paralogs for BAD Gene

Variants for BAD Gene

Sequence variations from dbSNP and Humsavar for BAD Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs15934 -- 64,270,264(-) AGTCT(C/T)CCAGT missense, reference
rs477895 -- 64,281,440(-) gcaga(A/G)gcagc intron-variant
rs660442 -- 64,275,525(-) GGGGC(C/T)GGTAG intron-variant
rs671976 -- 64,278,557(+) TTCCC(A/G)TTTAC intron-variant
rs687735 -- 64,279,680(+) atggc(A/G)tgaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAD Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
esv2744615 CNV Deletion 23290073
esv2744616 CNV Deletion 23290073
nsv897684 CNV Loss 21882294
nsv897685 CNV Loss 21882294
dgv1168n71 CNV Loss 21882294
nsv357 CNV Insertion 18451855

Relevant External Links for BAD Gene

HapMap Linkage Disequilibrium report
BAD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAD Gene

Disorders for BAD Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for BAD Gene including...

Search for BAD Gene in MalaCards »

(34) Novoseek inferred disease relationships for BAD Gene

Disease -log(P) Hits PubMed IDs
leukemia 41.2 3
prostate cancer 40.7 14
cancer 39.8 5
tumors 36.6 21
glioma 25.3 4

Relevant External Links for BAD

Genetic Association Database (GAD)
BAD
Human Genome Epidemiology (HuGE) Navigator
BAD
genes like me logo Genes that share disorders with BAD: view

No data available for UniProtKB/Swiss-Prot for BAD Gene

Publications for BAD Gene

  1. Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. (PMID: 9388232) Ottilie S. … Oltersdorf T. (J. Biol. Chem. 1997) 3 4 23
  2. Bcl-2 targets the protein kinase Raf-1 to mitochondria. (PMID: 8929532) Wang H.-G. … Reed J.C. (Cell 1996) 2 3 4
  3. Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad. (PMID: 17544220) Rusovici R. … Yun C.C. (Biochim. Biophys. Acta 2007) 3 23
  4. Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas. (PMID: 17557568) Yoo N.J. … Lee S.H. (Tumori 2007) 3 23
  5. Immunohistochemical analysis of phospho-BAD protein and mutational analysis of BAD gene in gastric carcinomas. (PMID: 17696955) Jeong E.G. … Lee S.H. (APMIS 2007) 3 23

Products for BAD Gene

  • Addgene plasmids for BAD

Sources for BAD Gene

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