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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BAD Gene

protein-coding GIFtS: 65
GCID: GC11M064037

BCL2-associated agonist of cell death

Explore 71 diseases affiliated with
BAD via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
BCL2-Associated Agonist Of Cell Death¹ ²		Bcl2 Antagonist Of Cell Death²
BCL2L8¹ ² ³ ⁵		Bcl2-L-8³
BBC2¹ ²		BCL2-Antagonist Of Cell Death Protein²
Bcl-2-Binding Component 6² ³		BCL2-Binding Component 6²
Bcl-2-Like Protein 8² ³		BCL2-Binding Protein²
Bcl-XL/Bcl-2-Associated Death Promoter² ³		BBC6³
BCL-X/BCL-2 Binding Protein²		Bcl2-L-8³

External Ids:	HGNC: 936¹	Entrez Gene: 572²	Ensembl: ENSG00000002330⁷	OMIM: 603167⁵	UniProtKB: Q92934³

Export aliases for BAD gene to outside databases

Previous GC identifers: GC11M066553 GC11M065718 GC11M064288 GC11M063812 GC11M063793 GC11M060365

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BAD:

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of

programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2,

and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its

phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be

involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which

encode the same isoform. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BAD_HUMAN, Q92934

Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting

the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but

not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic

pathways

Gene Wiki entry for BAD (Bcl-2-associated death promoter)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BAD gene promoter:
CREB ATF-2 deltaCREB c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BAD promoter sequence

Search SABiosciences Chromatin IP Primers for BAD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1

BAD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAD gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M064037: view genomic region (about GC identifiers)

Start:	64,037,300 bp from pter	End:	64,052,176 bp from pter
Size:	14,877 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BAD_HUMAN, Q92934 (See protein sequence)

Recommended Name: Bcl2 antagonist of cell death

Size: 168 amino acids; 18392 Da

Subunit: Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By

similarity). The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins (By similarity). Interacts with AKT1 and PIM3

Subcellular location: Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm

Sequence caution: Sequence=AAB36516.1; Type=Frameshift; Positions=64, 91;

1 PDB 3D structure from and Proteopedia for BAD:

1G5J (3D)

Secondary accessions: O14803 Q6FH21

Explore the universe of human proteins at neXtProt for BAD: NX_Q92934

Post-translational modifications:

Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its

pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This

interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of

Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major

site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blocked by

the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity during apoptosis¹

Methylation at Arg-94 and Arg-96 by PRMT1 inhibits Akt-mediated phosphorylation at Ser-99¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92934

BAD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004313.1 NP_116784.1

ENSEMBL proteins:

ENSP00000378040 ENSP00000309103 ENSP00000440575 ENSP00000378039 ENSP00000438975

ENSP00000439202

Reactome Protein details: Q92934
Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for BAD
	Uscn Proteins for BAD

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005739	mitochondrion	IDA	--
GO:0005741	mitochondrial outer membrane	TAS	--
GO:0005829	cytosol	TAS	--

BAD for ontologies About GeneDecksing

BAD Antibody Products:

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	ThermoFisher Antibody for BAD

Assay Products for BAD:

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	Cell Signaling Technology (CST) Sandwich ELISA Kits for BAD
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for BAD

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BAD for domains About GeneDecksing

1 InterPro domain/family:

IPR018868 Bcl-2_BAD

Graphical View of Domain Structure for InterPro Entry Q92934

ProtoNet protein and cluster: Q92934

1 Blocks protein family: IPB000712 Apoptosis regulator Bcl-2 protein

UniProtKB/Swiss-Prot: BAD_HUMAN, Q92934

Domain: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their

interaction with anti-apoptotic members of the Bcl-2 family

Similarity: Belongs to the Bcl-2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BAD_HUMAN, Q92934

Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting

the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but

not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic

pathways

miRNA Products:		OriGene 3'-UTR Clone (see all 2): BAD Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BAD
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		hsa-miR-3202 hsa-miR-1180
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for BAD

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		GenScript: all cDNA clones in your preferred vector (see all 2): BAD (NM_004322)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAD

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0005543	phospholipid binding	IMP	--
GO:0008289	lipid binding	IDA	19667065
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	IDA	18402937
GO:0019901	protein kinase binding	IPI	17270021

BAD for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for BAD:

Increased gamma-H2AX phosphory

Increased resistance to MDM2 i

Synthetic lethal with imatinib

Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-out Bad^tm1Sjk for BAD
10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Bad):

cellular	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	nervous system	reproductive system	tumorigenesis

BAD for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/76 super-pathways (see all 76) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PI-3K cascade	1.00	PI3K/AKT activation	0.97
PIP3 activates AKT signaling	1.00	GAB1 signalosome	0.96
PI3K/AKT Signaling in Cancer	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB2 signaling	1.00	Signaling by SCF-KIT	0.72

IL-9 Signaling Pathways

8/10 pathways (see all 10)
IL-9 Signaling Pathways	1.00	IL-15 Signaling Pathways	0.86
IL-21 Signaling Pathways	0.90	IL-4 Signaling Pathways	0.80
IL-7 Signaling Pathways	0.90	IL-7 Signaling Pathway	0.38
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways	0.90	Development_Thrombopoietin-regulated cell processes	0.36

Development HGF signaling pathway

Apoptosis and survival_NGF signaling pathway	0.25	Apoptosis and survival_Role of CDK5 in neuronal death and survival	0.24
Apoptosis and survival NGF signaling pathway	0.25	Apoptosis and survival Role of CDK5 in neuronal death and survival	0.24
Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR1	0.24	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	0.23
Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1	0.24	Neurotrophin signaling pathway	0.20

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	1.00	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins	0.24
Activation of BH3-only proteins	0.30	Intrinsic Pathway for Apoptosis	0.23
Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins	0.24	Activation of BAD and translocation to mitochondria	0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

5/15 EMD Millipore Pathways for BAD (see all 15)

	Apoptosis and survival NGF signaling pathway
	Signal transduction PTEN pathway
	Apoptosis and survival Role of CDK5 in neuronal death and survival
	Development A2A receptor signaling
	Signal transduction PKA signaling

5/8 R&D Systems Pathways for BAD (see all 8)

	IL-21 Signaling Pathways
	IL-2 Signaling Pathways
	IL-4 Signaling Pathways
	Apoptosis Signaling Pathways
	IL-7 Signaling Pathways

5/32 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BAD (see all 32)

	Caspase Cascade
	FLT3 Signaling
	14-3-3 Induced Apoptosis
	UVB-Induced MAPK Signaling
	IL-4 Pathway

3 Cell Signaling Technology (CST) Pathways for BAD

	MAP Kinase Signaling
	Apoptosis and Autophagy
	PI3K / Akt Signaling

1 Tocris Bioscience Pathway for BAD

VEGF Pathway

5/15 GeneGo (Thomson Reuters) Pathways for BAD (see all 15)

	Development A2A receptor signaling
	Apoptosis and survival BAD phosphorylation
	Signal transduction PKA signaling
	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
	Signal transduction AKT signaling

5/28 BioSystems Pathways for BAD (see all 28)

	DNA damage response (only ATM dependent)
	ErbB signaling pathway
	Integrated Breast Cancer Pathway
	Apoptosis Modulation and Signaling
	Focal Adhesion

5/38 Reactome Pathways for BAD (see all 38)

	Signaling by EGFR in Cancer
	Downstream signal transduction
	Intrinsic Pathway for Apoptosis
	Signal Transduction
	Signaling by PDGF

5/20 Kegg Pathways (Kegg details for BAD) (see all 20):

	ErbB signaling pathway
	Apoptosis
	VEGF signaling pathway
	Focal adhesion
	Neurotrophin signaling pathway

BAD for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BAD

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/93 Interacting proteins for BAD (Q92934^{1, 2, 3} ENSP00000309103⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 93)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SFN	P31947²^,³, ENSP00000340989⁴	MINT-8009673 MINT-66103 MINT-8009831 I2D: score=5 STRING: ENSP00000340989
BCL2	P10415¹^,³, ENSP00000329623⁴	EBI-700771,EBI-77694 I2D: score=8 STRING: ENSP00000329623
BCL2L11	O43521²^,³	MINT-7034091 MINT-7034079 I2D: score=1
NAF1	Q96HR8²^,³, ENSP00000274054⁴	MINT-7717137 I2D: score=1 STRING: ENSP00000274054
BCL2L1	Q07817²^,³, ENSP00000302564⁴	MINT-14701 MINT-14699 MINT-14700 MINT-7033976 I2D: score=8 STRING: ENSP00000302564

About this table

Gene Ontology (GO): 5/50 biological process terms (GO ID links to tree view) (see all 50): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006007	glucose catabolic process	IEA	--
GO:0006915	apoptotic process	TAS	--
GO:0006917	induction of apoptosis	IDA	19667065
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISS	--
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	--

BAD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BAD for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BAD
10/45 Novoseek chemical compound relationships for BAD gene (see all 45) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ly294002	67.5	13	14628071 (2), 14605879 (1), 15037618 (1), 17046344 (1) (see all 9)
phosphatidylinositol	62.5	15	16908594 (2), 10594015 (2), 11378270 (1), 12095980 (1) (see all 9)
wortmannin	62.2	9	12087097 (1), 17046344 (1), 15973355 (1), 10383455 (1) (see all 7)
pd 98,059	54.6	5	12087097 (1), 20200209 (1), 15037618 (1), 19747539 (1) (see all 5)
threonine	48.8	2	10597268 (1), 10102273 (1)
sp 600125	46.5	2	12527812 (1), 19747539 (1)
serine	45.2	16	10597268 (3), 19169818 (2), 12949797 (2), 11888916 (1) (see all 9)
phosphatidylserine	42.7	2	16603546 (1), 19266285 (1)
paclitaxel	40.9	16	12087097 (4), 19331146 (3), 9824152 (2), 19875160 (1) (see all 5)
phosphoinositide	36.4	6	10516287 (2), 17046344 (1), 12239175 (1), 9381178 (1)

Search CenterWatch for drugs/clinical trials and news about BAD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BAD gene (2 alternative transcripts):

NM_004322.3 NM_032989.2

Unigene Cluster for BAD:

BCL2-associated agonist of cell death

Hs.370254 [show with all ESTs]

Unigene Representative Sequence: AK023420

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394532(uc001nzc.3) ENST00000309032(uc001nzd.3) ENST00000544785

ENST00000394531 ENST00000493798 ENST00000492141 ENST00000544271(uc009ypk.2)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BAD

Additional cDNA sequence:

AB451254.1 AB451378.1 AF021792.1 AF031523.1 AK023420.1 AK291863.1 AK303051.1 AK309150.1

BC001901.2 BC095431.1 BT006678.1 CR541935.1 CR541959.1 U66879.1

10 DOTS entries:

DT.95103878 DT.446637 DT.92363242 DT.91875486 DT.40132326 DT.95247591 DT.120716499 DT.87015417

DT.91772691 DT.40210995

24/240 AceView cDNA sequences (see all 240):

CD245697 BM811187 CA426410 BM998802 BI917840 BQ675016 BM921686 BQ674086

BQ676958 BM667960 CF126337 AW300063 CA488397 AI127734 BI836511 BU751934

BM805363 BM464317 BM424198 AA358582 AI312078 CD673599 BU182782 CR541935

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for BAD (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	·	5e
SP1:			-						-		-		-
SP2:											-		-
SP3:			-
SP4:									-		-		-
SP5:

ECgene alternative splicing isoforms for BAD

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BAD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGCGCTGG

About this image
See BAD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BAD

SOURCE GeneReport for Unigene cluster: Hs.370254

UniProtKB/Swiss-Prot: BAD_HUMAN, Q92934

Tissue specificity: Expressed in a wide variety of tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including BAD (see all 10):

HIV Host Response in human mouse rat

Autophagy in human mouse rat

VEGF Signaling in human mouse rat

Apoptosis in human mouse rat

T-cell & B-cell Activation in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BAD

In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for BAD gene from 2/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Bad^{1 , 5}	BCL2-associated agonist of cell death^{1, 5}	83.13(n)¹ 77.78(a)¹		19 (5.10 cM)⁵ 12015¹ NM_007522.2¹ NP_031548.1¹ 6941861⁵
zebrafish (Danio rerio)	Actinopterygii	badb⁶ BX530031.1⁶	--	35(a) 30(a)	many → 1 many → 1	7(26296611-26300944) 21(26583884-26584502)

ENSEMBL Gene Tree for BAD (if available)
TreeFam Gene Tree for BAD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141176750^1,2		--	64036922(+)	`ACCGCA/GCTGCT`	4	--	ds500¹ ut3¹		0	--	--	--	--
rs145031899^1,2		--	64036933(+)	`GCCAGA/CCTGGC`	4	--	ds500¹		0	--	--	--	--
rs876064^1,2	C,F,A,H,	--	64037033(+)	`TAGGAG/ACGAGT`	4	--	ds500¹		21		NS EA NA WA	2696
rs3741400^1,2	C	--	64037358(+)	`GGGCAT/CCGCGG`	4	--	ut3¹ ds500¹ ese³		1		NA	2
rs190892320^1,2		--	64037387(+)	`CGCAAC/TGGTTA`	4	--	ut3¹ ds500¹		0	--	--	--	--
rs10556^1,2	C,F,A,H,	--	64037407(-)	`GCTAAG/ATCGCG`	4	--	ut3¹ ds500¹ ese³		7		MN NA WA CSA EA	428
rs73500186^1,2	C,	--	64037481(+)	`TGGGCG/AGAAAA`	2	--	ut3¹		1		WA	2
rs186286987^1,2		--	64037513(+)	`AAGCCC/TTCCGT`	2	--	ut3¹		0	--	--	--	--
rs144873026^1,2	C,F,	--	64037602(+)	`CCTGAG/CGGAAG`	2	--	ut3¹		1		EU	165
rs59283629^1,2	C,F,	--	64037679(+)	`GCGAAG/AGTCAC`	2	--	ut3¹		1		EA	120

HapMap Linkage Disequilibrium report for BAD (64037300 - 64052176 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BAD: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BAD for disorders           About GeneDecksing

OMIM gene information: 603167    OMIM disorders: --

20/71 diseases for BAD (see all 71):    About MalaCards

spinal cord injury spinal muscular atrophy diffuse large b-cell lymphoma transient cerebral ischemia

amyotrophic lateral sclerosis (als) amyotrophic lateral sclerosis b-cell lymphomas non-hodgkin lymphoma

lateral sclerosis muscular atrophy laryngeal squamous cell carcinoma myeloid leukemia

asthenopia squamous cell carcinoma hodgkin's lymphoma transitional cell carcinoma

chronic lymphocytic leukemia chronic myeloid leukemia acute myeloid leukemia lymphocytic leukemia

10/34 Novoseek disease relationships for BAD gene (see all 34) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	41.2	3	11992636 (1), 14628071 (1), 17510658 (1)
prostate cancer	40.7	20	19593445 (7), 19055752 (1), 10861750 (1), 19509254 (1) (see all 8)
cancer	39.8	5	15033904 (1), 17696955 (1), 17353197 (1), 12949797 (1) (see all 5)
tumors	36.6	28	9422523 (3), 19593445 (3), 12754297 (2), 10383455 (2) (see all 14)
glioma	25.3	5	19212678 (1), 15015772 (1), 11027222 (1), 15451022 (1)
transient cerebral ischemia	23.7	1	15710244 (1)
myeloid leukemia	22.2	1	14628071 (1)
necrosis	21.4	12	12754297 (2), 10383455 (2), 15121878 (2), 12696008 (1) (see all 9)
somatic mutations	21.3	11	16807152 (2), 17696955 (2), 16484005 (2), 17557568 (2) (see all 5)
colon cancer	20.8	8	15033904 (1), 17544220 (1), 15024076 (1)

Human Genome Epidemiology (HuGE) Navigator: BAD (73 documents)

Export disorders for BAD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BAD gene, integrated from 9 sources (see all 531):
(articles sorted by number of sources associating them with BAD)

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Bcl-2 targets the protein kinase Raf-1 to mitochondria. (PubMed id 8929532)^{1, 2, 3, 9} Wang H.-G.... Reed J.C. (1996)
Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. (PubMed id 9388232)^{1, 2, 9} Ottilie S.... Oltersdorf T. (1997)
Arginine methylation of BCL-2 antagonist of cell deat h (BAD) counteracts its phosphorylation and inactivation by Akt. (PubMed id 21444773)^{1, 2} Sakamaki J....Fukamizu A. (2011)
Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad- mediated apoptosis. (PubMed id 17270021)^{1, 2} Popivanova B.K....Mukaida N. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. (PubMed id 12897128)^{1, 2} Cotteret S....Chernoff J. (2003)
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. (PubMed id 11206074)^{1, 2} Petros A.M....Fesik S.W. (2000)
Expression of the Bcl-2 protein BAD promotes prostate cancer growth. (PubMed id 19593445)^{1, 9} Smith A.J....Kulik G. (2009)
Reversible membrane interaction of BAD requires two C-terminal lipid binding domains in conjunction with 14-3-3 protein binding. (PubMed id 16603546)^{1, 9} Hekman M....Rapp U.R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 572	HGNC: 936	AceView: BAD	Ensembl:ENSG00000002330	euGenes: HUgn572
ECgene: BAD	Kegg: 572	H-InvDB: BAD

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BAD	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BAD	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Bcl-2-associated_death_promoter

Intellectual Property for BAD gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BAD gene:
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GeneCards and IP:
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BCL2-associated agonist of cell death

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BAD Gene

BCL2-associated agonist of cell death

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