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BAD Gene

protein-coding   GIFtS: 69
GCID: GC11M064037

BCL2-Associated Agonist Of Cell Death

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
BCL2-Associated Agonist Of Cell Death1 2     Bcl2 Antagonist Of Cell Death2
BCL2L82 3 5     bcl2-L-82
Bcl-2-Binding Component 62 3     BCL2-Antagonist Of Cell Death Protein2
Bcl-2-Like Protein 82 3     BCL2-Binding Component 62
Bcl-XL/Bcl-2-Associated Death Promoter2 3     BCL2-Binding Protein2
BBC22     BBC63
BCL-X/BCL-2 Binding Protein2     Bcl2-L-83

External Ids:    HGNC: 9361   Entrez Gene: 5722   Ensembl: ENSG000000023307   OMIM: 6031675   UniProtKB: Q929343   
ORGUL members:         

Export aliases for BAD gene to outside databases

Previous GC identifers: GC11M066553 GC11M065718 GC11M064288 GC11M063812 GC11M063793 GC11M060365


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BAD Gene:
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators
of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL
and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated
through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were
found to be involved in the regulation of this protein. Alternative splicing of this gene results in two
transcript variants which encode the same isoform. (provided by RefSeq, Jul 2008)

GeneCards Summary for BAD Gene:
BAD (BCL2-associated agonist of cell death) is a protein-coding gene. Diseases associated with BAD include asthenopia, and transient cerebral ischemia. GO annotations related to this gene include protein kinase binding and protein heterodimerization activity.

UniProtKB/Swiss-Prot: BAD_HUMAN, Q92934
Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby
affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of
Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor
signaling and the apoptotic pathways

Gene Wiki entry for BAD (Bcl-2-associated death promoter) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BAD gene promoter:
         CREB   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBAD promoter sequence
   Search Chromatin IP Primers for BAD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BAD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

BAD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BAD gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M064037:  view genomic region     (about GC identifiers)

Start:
64,037,300 bp from pter      End:
64,052,176 bp from pter
Size:
14,877 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BAD_HUMAN, Q92934 (See protein sequence)
Recommended Name: Bcl2 antagonist of cell death  
Size: 168 amino acids; 18392 Da
Subunit: Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein
S100A10 (By similarity). The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins (By similarity). Interacts
with AKT1 and PIM3
Sequence caution: Sequence=AAB36516.1; Type=Frameshift; Positions=64, 91;
1 PDB 3D structure from and Proteopedia for BAD:
1G5J (3D)    
Secondary accessions: O14803 Q6FH21

Explore the universe of human proteins at neXtProt for BAD: NX_Q92934

Explore proteomics data for BAD at MOPED

Post-translational modifications: 

  • Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks
    its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins.
    This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the
    release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation,
    Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is
    almost completely blocked by the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity
    during apoptosis1
  • Methylation at Arg-94 and Arg-96 by PRMT1 inhibits Akt-mediated phosphorylation at Ser-991
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BAD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004313.1  NP_116784.1  

    ENSEMBL proteins: 
     ENSP00000378040   ENSP00000309103   ENSP00000440575   ENSP00000378039   ENSP00000438975  
     ENSP00000439202  
    Reactome Protein details: Q92934

    BAD Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant BAD Protein
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    Novus Biologicals BAD Proteins
    Novus Biologicals BAD Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for BAD
    Cloud-Clone Corp. Proteins for BAD

    BAD Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BAD
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    Abcam antibodies for BAD
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    BAD Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for BAD         (see all)
    GenScript Custom Assay Services for BAD
    Cell Signaling Technology (CST) Sandwich ELISA Kits for BAD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BAD
    Cloud-Clone Corp. CLIAs for BAD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018868 Bcl-2_BAD

    Graphical View of Domain Structure for InterPro Entry Q92934

    ProtoNet protein and cluster: Q92934

    1 Blocks protein domain: IPB000712 Apoptosis regulator Bcl-2 protein

    UniProtKB/Swiss-Prot: BAD_HUMAN, Q92934
    Domain: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their
    interaction with anti-apoptotic members of the Bcl-2 family
    Similarity: Belongs to the Bcl-2 family


    BAD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BAD_HUMAN, Q92934
    Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby
    affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of
    Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor
    signaling and the apoptotic pathways

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10949025
    GO:0005543phospholipid binding IMP--
    GO:0008289lipid binding IDA19667065
    GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process IDA18402937
    GO:0019901protein kinase binding IPI17270021
         
    BAD for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for BAD:
     Increased gamma-H2AX phosphory  Increased resistance to MDM2 i  Synthetic lethal with imatinib  Upregulation of Wnt/beta-caten 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Bad):
     cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  reproductive system  tumorigenesis 

    BAD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Badtm1Sjk for BAD

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BAD
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BAD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BAD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BAD

    miRNA
    Products:
        
    miRTarBase miRNAs that target BAD:
    hsa-mir-330-5p (MIRT038239)

    Block miRNA regulation of human, mouse, rat BAD using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate BAD:
    hsa-miR-3202 hsa-miR-1180
    SwitchGear 3'UTR luciferase reporter plasmidBAD 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BAD
    Predesigned siRNA for gene silencing in human, mouse, rat BAD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BAD

    Clone
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    OriGene clones in human, mouse for BAD (see all 11)
    OriGene ORF clones in mouse, rat for BAD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BAD (NM_004322)
    Sino Biological Human cDNA Clone for BAD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BAD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAD

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for BAD 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BAD_HUMAN, Q92934: Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion5
    nucleus2
    endosome1
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane TAS--
    GO:0005829cytosol TAS--

    BAD for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BAD About   (see all 82)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-15 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-21 Signaling Pathways0.90
    IL-7 Signaling Pathway0.40
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Development Thrombopoietin regulated cell processes0.38
    2Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    3Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    VEGF signaling pathway0.39
    4Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Pathogenesis of ALS0.31
    Amyotrophic lateral sclerosis (ALS)0.63
    5Endometrial cancer
    Endometrial cancer0.45
    Colorectal cancer0.42
    Signal transduction PTEN pathway0.45
    Acute myeloid leukemia0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for BAD (see all 10)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Apoptosis Signaling Pathways
    Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BAD (see all 32)
        Caspase Cascade
    FLT3 Signaling
    14-3-3 Induced Apoptosis
    UVB-Induced MAPK Signaling
    IL-4 Pathway

    3 Cell Signaling Technology (CST) Pathways for BAD
        MAP Kinase Signaling
    Apoptosis and Autophagy
    PI3K / Akt Signaling

    1 Tocris Bioscience Pathway for BAD
        VEGF Pathway

    Selected GeneGo (Thomson Reuters) Pathways for BAD (see all 15)
        Development A2A receptor signaling
    Apoptosis and survival BAD phosphorylation
    Signal transduction PKA signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Signal transduction AKT signaling

    Selected BioSystems Pathways for BAD (see all 31)
        Focal Adhesion
    Apoptosis
    Apoptosis Modulation and Signaling
    DNA damage response (only ATM dependent)
    ErbB signaling pathway


    5 Reactome Pathways for BAD
        AKT phosphorylates targets in the cytosol
    Activation of BAD and translocation to mitochondria
    Constitutive PI3K/AKT Signaling in Cancer
    NRAGE signals death through JNK
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members


    Selected Kegg Pathways  (Kegg details for BAD) (see all 25):
        ErbB signaling pathway
    Ras signaling pathway
    PI3K-Akt signaling pathway
    Apoptosis
    VEGF signaling pathway


    BAD for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BAD (see all 10): 
              HIV Host Response in human mouse rat
              Autophagy in human mouse rat
              VEGF Signaling in human mouse rat
              Apoptosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BAD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BAD (Q929341, 2, 3 ENSP000003091034) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 66):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia ----
    GO:0001836release of cytochrome c from mitochondria IEA--
    GO:0006007glucose catabolic process IEA--
    GO:0006915apoptotic process TAS7834748
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process ISS--

    BAD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for BAD (see all 19)     About this table
    CompoundAction CAS #
    2,3-DCPE hydrochlorideSelectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro[418788-90-6]
    ABT-199Selective Bcl-2 inhibitor[1257044-40-8]
    ABT-263 (Navitoclax)orally sellecitive inhibitor of Bcl-2 family proteins[923564-51-6]
    ABT-737novel and potent inhibitor of BCL-2 family proteins[852808-04-9]
    Apogossypolone (ApoG2)pan Bcl-2 inhibitor[886578-07-0]
    AT-101R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1[90141-22-3]
    Bax channel blockerPotent inhibitor of Bax-mediated mitochondrial cytochrome c release[335165-68-9]
    Bax inhibitor peptide P5Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria[579492-83-4]
    Bax inhibitor peptide V5Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria[579492-81-2]
    Bax inhibitor peptide, negative controlNegative control peptide for the Bax inhibitor peptides V5 and P5[1315378-74-5]

    Browse Tocris compounds for BAD

    Selected Novoseek inferred chemical compound relationships for BAD gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ly294002 67.5 13 14628071 (2), 14605879 (1), 15037618 (1), 17046344 (1) (see all 9)
    phosphatidylinositol 62.5 15 16908594 (2), 10594015 (2), 11378270 (1), 12095980 (1) (see all 9)
    wortmannin 62.2 9 12087097 (1), 17046344 (1), 15973355 (1), 10383455 (1) (see all 7)
    pd 98,059 54.6 5 12087097 (1), 20200209 (1), 15037618 (1), 19747539 (1) (see all 5)
    threonine 48.8 2 10597268 (1), 10102273 (1)
    sp 600125 46.5 2 12527812 (1), 19747539 (1)
    serine 45.2 16 10597268 (3), 19169818 (2), 12949797 (2), 11888916 (1) (see all 9)
    phosphatidylserine 42.7 2 16603546 (1), 19266285 (1)
    paclitaxel 40.9 16 12087097 (4), 19331146 (3), 9824152 (2), 19875160 (1) (see all 5)
    phosphoinositide 36.4 6 10516287 (2), 17046344 (1), 12239175 (1), 9381178 (1)



    BAD for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for BAD gene (2 alternative transcripts): 
    NM_004322.3  NM_032989.2  

    Unigene Cluster for BAD:

    BCL2-associated agonist of cell death
    Hs.370254  [show with all ESTs]
    Unigene Representative Sequence: AK023420
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394532(uc001nzc.3) ENST00000309032(uc001nzd.3) ENST00000544785
    ENST00000394531 ENST00000493798 ENST00000492141 ENST00000544271(uc009ypk.2)

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate BAD:
    hsa-miR-3202 hsa-miR-1180
    SwitchGear 3'UTR luciferase reporter plasmidBAD 3' UTR sequence
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for BAD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BAD (NM_004322)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BAD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BAD
    Primer
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    OriGene qPCR primer pairs and template standards for BAD
    OriGene qSTAR qPCR primer pairs in human, mouse for BAD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BAD
      QuantiTect SYBR Green Assays in human, mouse, rat BAD
      QuantiFast Probe-based Assays in human, mouse, rat BAD

    Additional mRNA sequence: 

    AB451254.1 AB451378.1 AF021792.1 AF031523.1 AK023420.1 AK291863.1 AK303051.1 AK309150.1 
    BC001901.2 BC095431.1 BT006678.1 CR541935.1 CR541959.1 U66879.1 

    10 DOTS entries:

    DT.95103878  DT.446637  DT.92363242  DT.91875486  DT.40132326  DT.95247591  DT.120716499  DT.87015417 
    DT.91772691  DT.40210995 

    Selected AceView cDNA sequences (see all 240):

    AW026970 AA358582 BM424198 BQ676958 BU191319 CR541935 AI675411 CF126337 
    BM464317 CR541959 BI917840 BQ276268 BE266628 BM667960 BF447975 BM811187 
    AI659154 BU182782 CF541292 AI193474 NM_004322 AI312078 BQ674086 BC001901 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BAD (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
    SP1:        -                 -     -     -                                       
    SP2:                                -     -                                       
    SP3:        -                                                                     
    SP4:                          -     -     -                                       
    SP5:                                                                              


    ECgene alternative splicing isoforms for BAD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BAD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGCGCTGG
    BAD Expression
    About this image


    BAD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
    BAD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BAD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370254

    UniProtKB/Swiss-Prot: BAD_HUMAN, Q92934
    Tissue specificity: Expressed in a wide variety of tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BAD (see all 10): 
              HIV Host Response in human mouse rat
              Autophagy in human mouse rat
              VEGF Signaling in human mouse rat
              Apoptosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BAD gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bad1 , 5 BCL2-associated agonist of cell death1, 5 82.92(n)1
    77.78(a)1
      19 (5.10 cM)5
    120151  NM_007522.31  NP_031548.11 
     69418615 
    zebrafish
    (Danio rerio)
    Actinopterygii badb6
    bada6
    BCL2-antagonist of cell death a
    39(a)
    34(a)
    many → 1
    many → 1
    7(26296611-26300944) ENSDARG00000054937
    21(26583884-26584502) ENSDARG00000087993


    ENSEMBL Gene Tree for BAD (if available)
    TreeFam Gene Tree for BAD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BAD (see all 275)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345775961,2
    C--63960640(+) ATCTC-/AAAAAA 2 -- int11Minor allele frequency- A:0.50NA 2
    rs735001861,2
    C,F--64037481(+) TGGGCG/AGAAAA 2 -- ut311Minor allele frequency- A:0.50WA 2
    rs1862869871,2
    --64037513(+) AAGCCC/TTCCGT 2 -- ut310--------
    rs1448730261,2
    C,F--64037602(+) CCTGAG/CGGAAG 2 -- ut311Minor allele frequency- C:0.02EU 165
    rs592836291,2
    C,F--64037679(+) GCGAAG/AGTCAC 2 -- ut311Minor allele frequency- A:0.07EA 120
    rs1997596871,2
    --64037700(+) CGGAGC/GTTCCC 4 T S mis10--------
    rs797234891,2
    C,F--64037702(+) GAGCTT/ACCCCT 4 /G syn12Minor allele frequency- A:0.00WA NA 4668
    rs2010469611,2
    C--64037710(+) CCTGCA/C/GCAAGT 6 R G C mis10--------
    rs1390932601,2
    C,F--64037726(+) TCCCAC/GCAGGA 4 C W mis11Minor allele frequency- G:0.00NA 4550
    rs159341,2
    C--64037736(-) AGTCTT/CCCAGT 4 /S /F mis1 ese34Minor allele frequency- C:0.00MN EA NA 350

    HapMap Linkage Disequilibrium report for BAD (64037300 - 64052176 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BAD (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744616CNV Deletion23290073
    esv2744615CNV Deletion23290073
    nsv357CNV Insertion18451855
    nsv897685CNV Loss21882294
    dgv1168n71CNV Loss21882294
    dgv1165n71CNV Loss21882294
    dgv1166n71CNV Loss21882294
    dgv1156n71CNV Loss21882294
    nsv897684CNV Loss21882294
    nsv832186CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BAD
    DNA2.0 Custom Variant and Variant Library Synthesis for BAD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603167    OMIM disorders: --

    Selected diseases for BAD (see all 70):    
    About MalaCards
    asthenopia    transient cerebral ischemia    ischemia    toxoplasmosis
    spinal cord injury    spinal muscular atrophy    laryngeal squamous cell carcinoma    cutaneous t cell lymphoma
    vaginitis    pancreatic cancer    cerebritis    acute leukemia
    muscular atrophy    b-cell lymphomas    myeloid leukemia    diffuse large b-cell lymphoma
    conjunctivitis    transitional cell carcinoma    parkinson's disease    laryngitis


    BAD for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for BAD gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 41.2 3 11992636 (1), 14628071 (1), 17510658 (1)
    prostate cancer 40.7 20 19593445 (7), 19055752 (1), 10861750 (1), 19509254 (1) (see all 8)
    cancer 39.8 5 15033904 (1), 17696955 (1), 17353197 (1), 12949797 (1) (see all 5)
    tumors 36.6 28 9422523 (3), 19593445 (3), 12754297 (2), 10383455 (2) (see all 14)
    glioma 25.3 5 19212678 (1), 15015772 (1), 11027222 (1), 15451022 (1)
    transient cerebral ischemia 23.7 1 15710244 (1)
    myeloid leukemia 22.2 1 14628071 (1)
    necrosis 21.4 12 12754297 (2), 10383455 (2), 15121878 (2), 12696008 (1) (see all 9)
    somatic mutations 21.3 11 16807152 (2), 17696955 (2), 16484005 (2), 17557568 (2) (see all 5)
    colon cancer 20.8 8 15033904 (1), 17544220 (1), 15024076 (1)

    Genetic Association Database (GAD): BAD
    Human Genome Epidemiology (HuGE) Navigator: BAD (73 documents)

    Export disorders for BAD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BAD gene, integrated from 10 sources (see all 542):
    (articles sorted by number of sources associating them with BAD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bcl-2 targets the protein kinase Raf-1 to mitochondria. (PubMed id 8929532)1, 2, 3, 9 Wang H.-G.... Reed J.C. (Cell 1996)
    2. Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. (PubMed id 9388232)1, 2, 9 Ottilie S.... Oltersdorf T. (J. Biol. Chem. 1997)
    3. A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. (PubMed id 22423221)1, 4 Qayyum R....Reiner A.P. (PLoS Genet. 2012)
    4. Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt. (PubMed id 21444773)1, 2 Sakamaki J....Fukamizu A. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    5. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (amp 2010)
    6. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    9. Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease. (PubMed id 18568448)1, 4 Mizuta I....Toda T. (Hum. Genet. 2008)
    10. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PubMed id 18636124)1, 4 Skibola C.F....Smith M.T. (PLoS ONE 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 572 HGNC: 936 AceView: BAD Ensembl:ENSG00000002330 euGenes: HUgn572
    ECgene: BAD Kegg: 572 H-InvDB: BAD

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BAD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BAD Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Bcl-2-associated_death_promoter

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BAD gene:
    Search GeneIP for patents involving BAD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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