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Aliases for BACH2 Gene

Aliases for BACH2 Gene

  • BTB And CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 2 3
  • BTB And CNC Homolog 2 3 4
  • Transcription Regulator Protein BACH2 3
  • BTBD25 3

External Ids for BACH2 Gene

Summaries for BACH2 Gene

GeneCards Summary for BACH2 Gene

BACH2 (BTB And CNC Homology 1, Basic Leucine Zipper Transcription Factor 2) is a Protein Coding gene. Among its related pathways are Lymphocyte Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is NFE2.

UniProtKB/Swiss-Prot for BACH2 Gene

  • Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1.

Gene Wiki entry for BACH2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BACH2 Gene

Genomics for BACH2 Gene

Genomic Location for BACH2 Gene

Start:
89,926,528 bp from pter
End:
90,296,908 bp from pter
Size:
370,381 bases
Orientation:
Minus strand

Genomic View for BACH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BACH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BACH2 Gene

Regulatory Elements for BACH2 Gene

Proteins for BACH2 Gene

  • Protein details for BACH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYV9-BACH2_HUMAN
    Recommended name:
    Transcription regulator protein BACH2
    Protein Accession:
    Q9BYV9
    Secondary Accessions:
    • E1P518
    • Q59H70
    • Q5T793
    • Q9NTS5

    Protein attributes for BACH2 Gene

    Size:
    841 amino acids
    Molecular mass:
    92537 Da
    Quaternary structure:
    • Heterodimer of BACH2 and Maf-related transcription factors (By similarity). Homodimer; disulfide-linked.
    SequenceCaution:
    • Sequence=BAD92126.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BACH2 Gene

neXtProt entry for BACH2 Gene

Proteomics data for BACH2 Gene at MOPED

Post-translational modifications for BACH2 Gene

  • Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export.
  • The reversible disulfide bond may provide mechanism to regulate the activity in oxidative stress responses
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BACH2 Gene

No data available for DME Specific Peptides for BACH2 Gene

Domains for BACH2 Gene

Gene Families for BACH2 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • bZIP :basic leucine zipper proteins

Suggested Antigen Peptide Sequences for BACH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYV9

UniProtKB/Swiss-Prot:

BACH2_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • Q9BYV9
  • Contains 1 bZIP (basic-leucine zipper) domain.:
    • Q9BYV9
Family:
  • Belongs to the bZIP family. CNC subfamily.:
    • Q9BYV9
genes like me logo Genes that share domains with BACH2: view

Function for BACH2 Gene

Molecular function for BACH2 Gene

UniProtKB/Swiss-Prot Function: Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1.

Gene Ontology (GO) - Molecular Function for BACH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001206 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with BACH2: view
genes like me logo Genes that share phenotypes with BACH2: view

Animal Models for BACH2 Gene

MGI Knock Outs for BACH2:

miRNA for BACH2 Gene

miRTarBase miRNAs that target BACH2
Targeting motifs for BACH2 Gene
HOMER Transcription Factor Regulatory Elements motif BACH2
  • Consensus sequence: TGCTGAGTCA Submotif: canonical Cell Type: OCILy7 GeoId: GSE44420

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for BACH2 Gene

Localization for BACH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BACH2 Gene

Cytoplasm. Nucleus. Note=Nucleocytoplasmic shuttling is controlled by phosphorylation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BACH2 Gene COMPARTMENTS Subcellular localization image for BACH2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for BACH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BACH2: view

Pathways for BACH2 Gene

SuperPathways for BACH2 Gene

Superpath Contained pathways
1 Lymphocyte Signaling
genes like me logo Genes that share pathways with BACH2: view

Pathways by source for BACH2 Gene

1 Cell Signaling Technology pathway for BACH2 Gene

Gene Ontology (GO) - Biological Process for BACH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with BACH2: view

Compounds for BACH2 Gene

(6) Novoseek inferred chemical compound relationships for BACH2 Gene

Compound -log(P) Hits PubMed IDs
leucine 52.4 3
12-o-tetradecanoylphorbol 13-acetate 43.3 1
retinoid 43 1
imatinib 41.3 5
tyrosine 13.7 1
genes like me logo Genes that share compounds with BACH2: view

Transcripts for BACH2 Gene

Unigene Clusters for BACH2 Gene

BTB and CNC homology 1, basic leucine zipper transcription factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BACH2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - - -
SP3:

Relevant External Links for BACH2 Gene

GeneLoc Exon Structure for
BACH2
ECgene alternative splicing isoforms for
BACH2

Expression for BACH2 Gene

mRNA expression in normal human tissues for BACH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BACH2 Gene

SOURCE GeneReport for Unigene cluster for BACH2 Gene Hs.269764

mRNA Expression by UniProt/SwissProt for BACH2 Gene

Q9BYV9-BACH2_HUMAN
Tissue specificity: B-cell specific
genes like me logo Genes that share expressions with BACH2: view

No data available for mRNA differential expression in normal tissues for BACH2 Gene

Orthologs for BACH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BACH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BACH2 35
  • 99.08 (n)
  • 99.39 (a)
BACH2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BACH2 35
  • 90.61 (n)
  • 93.58 (a)
BACH2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BACH2 35
  • 91.62 (n)
  • 92.85 (a)
BACH2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bach2 35
  • 87.95 (n)
  • 90.33 (a)
Bach2 16
Bach2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BACH2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia RGD1562865 35
  • 87.51 (n)
  • 90.33 (a)
chicken
(Gallus gallus)
Aves BACH2 35
  • 79.83 (n)
  • 81.29 (a)
BACH2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BACH2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bach2 35
  • 73.08 (n)
  • 74.85 (a)
zebrafish
(Danio rerio)
Actinopterygii bach2b 35
  • 64.48 (n)
  • 61.62 (a)
bach2b 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cnc 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for BACH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BACH2 Gene

ENSEMBL:
Gene Tree for BACH2 (if available)
TreeFam:
Gene Tree for BACH2 (if available)

Paralogs for BACH2 Gene

Paralogs for BACH2 Gene

genes like me logo Genes that share paralogs with BACH2: view

Variants for BACH2 Gene

Sequence variations from dbSNP and Humsavar for BACH2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9111 -- 90,271,934(-) CGTTC(A/G)TTCAC intron-variant, utr-variant-5-prime
rs85706 -- 90,098,285(+) CCGCA(A/C)CCCCC intron-variant
rs112841 -- 90,111,878(-) ACCTG(A/C)TGTGT intron-variant
rs176713 -- 89,961,395(-) TTCGA(A/G)TGAAA intron-variant
rs182382 -- 89,938,040(-) CTTTG(C/G)GGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BACH2 Gene

Variant ID Type Subtype PubMed ID
esv273328 CNV Insertion 20981092
esv268972 CNV Insertion 20981092
esv275360 CNV Gain+Loss 21479260
esv270781 CNV Insertion 20981092
esv2499312 CNV Deletion 19546169
esv28039 CNV Loss 19812545

Relevant External Links for BACH2 Gene

HapMap Linkage Disequilibrium report
BACH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BACH2 Gene

Disorders for BACH2 Gene

(4) Novoseek inferred disease relationships for BACH2 Gene

Disease -log(P) Hits PubMed IDs
myeloid leukemia chronic 45.1 1
lymphoma non-hodgkins 23.3 2
leukemia 8.36 2
tumors 0 1

Relevant External Links for BACH2

Genetic Association Database (GAD)
BACH2
Human Genome Epidemiology (HuGE) Navigator
BACH2
genes like me logo Genes that share disorders with BACH2: view

No data available for UniProtKB/Swiss-Prot for BACH2 Gene

Publications for BACH2 Gene

  1. Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15. (PMID: 10949928) Sasaki S. … Yokoyama M. (Oncogene 2000) 2 3 4 23
  2. Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene. (PMID: 11746976) Vieira S.A.D. … Melo J.V. (Genes Chromosomes Cancer 2001) 3 4 23
  3. B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs. (PMID: 12829606) Kamio T. … Ito E. (Blood 2003) 2 3 23
  4. Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1. (PMID: 17018862) Yoshida C. … Melo J.V. (Blood 2007) 3 4 23
  5. Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression. (PMID: 17383980) Hoshino H. … Yoshida M. (J. Biochem. 2007) 3 23

Products for BACH2 Gene

Sources for BACH2 Gene

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