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BACH2 Gene

protein-coding   GIFtS: 57

GC06M090692
BTB and CNC homology 1, basic leucine zipper transcription factor 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
OTTHUMP00000016867 2
OTTHUMP00000016868 2
OTTHUMP00000040591 2
Descriptions
BTB and CNC homolog 2 3
BTB and CNC homology 1, basic leucine zipper transcription
factor 2 2
External Ids
HGNC: 140781
Entrez Gene: 604682
UniProtKB: Q9BYV93
Ensembl: ENSG000001121827
Search outside databases for aliases for BACH2 gene

Previous GC identifers: GC06M090582 GC06M090631

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9
Function: Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition
elements (MARE). Play important roles in coordinating transcription activation and repression by
MAFK (By similarity)

Gene Wiki entry for BACH2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BACH2 gene  

Entrez Gene cytogenetic band: 6q15   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q15

BACH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M090692:     (about GC identifiers)

Start:
90,692,969 bp from pter
End:
91,063,182 bp from pter
Size:
370,214 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000006.10  NT_007299.12  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9 (See protein sequence)
Recommended Name: Transcription regulator protein BACH2  
Size: 841 amino acids; 92537 Da
Subunit: Heterodimer of BACH2 and Maf-related transcription factors (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q59H70 Q5T793 Q9NTS5

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_068585.1  

    ENSEMBL proteins: 
    ENSP00000257749 ENSP00000345642 ENSP00000384145 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (BACH2)
    Human Recombinant Proteins from Abnova (BACH2)
                  OriGene Purified Recombinant Human Protein: BACH2 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for BACH2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (BACH2), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for BACH2

    Assays for BACH2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR004827 TF_bZIP
     IPR011333 BTB/POZ_fold
     IPR011616 bZIP_1
     IPR013069 BTB_POZ
     IPR013089 Kelch_related


       GeneDecks  BACH2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9BYV9

    ProtoNet protein and cluster: Q9BYV9

    2 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9
    Similarity: Belongs to the bZIP family. CNC subfamily
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 1 bZIP domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BACH2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BACH2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021813

                  Applied Biosystems Silencer® siRNAs for BACH2

                  Sigma-Aldrich siRNA and siRNA Panels for BACH2  
                         Sigma-Aldrich shRNA for BACH2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_021813
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_021813
                                     untagged cDNA clone in CMV expression vector: NM_021813 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_021813

    UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9
    Function: Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition
    elements (MARE). Play important roles in coordinating transcription activation and repression by
    MAFK (By similarity)

    2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bach2):

    hematopoietic systemimmune system

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 transcription factor activity IEA--
    GO:0043565 sequence-specific DNA binding IEA--
    GO:0046983 protein dimerization activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  BACH2 


    5/15 Interacting proteins for BACH2 (ENSP000003456423) via UniProtKB, MINT, and/or STRING (see all 15 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAFENSP000003270483STRING (score=.985)
    C16orf35ENSP000002623133STRING (score=.977)
    PRDM1ENSP000000712463STRING (score=.973)
    HDAC4ENSP000002646063STRING (score=.925)
    MAFKENSP000003449033STRING (score=.872)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for BACH2
    4 Novoseek chemical compound relationships for BACH2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 52.97 3 15060166 (1), 17383980 (1), 9565602 (1)
    12-o-tetradecanoylphorbol 13-acetate 43.58 1 15060166 (1)
    tyrosine 14.55 1 12829606 (1)
    oxygen 0.00 2 12829606 (1), 17018862 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BACH2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BACH2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021813

                  Sigma-Aldrich siRNA and siRNA Panels for BACH2  
                         Sigma-Aldrich shRNA for BACH2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_021813  

    REFSEQ mRNAs for BACH2 gene: 

    NM_021813.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_021813  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_021813
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_021813
                                     untagged cDNA clone in CMV expression vector: NM_021813 

    Additional cDNA sequence: 

    AB208889.1 AF357835.1 AJ271878.1 

    5 DOTS entries:

    DT.428799  DT.100749486  DT.91746418  DT.100701438  DT.100727669 

    24/91 AceView cDNA sequences (see all 91 ):

    AA748480 H91131 AI187096 AI471915 AL512739 Z43962 Z40021 AA737041 
    AA721741 BQ421487 BQ187418 AA488974 AW505021 AL157663 R37011 AA767318 
    CF143478 AA832164 BC070239 CD522675 AA279412 AA749185 AF357835 BP366626 

    highest scoring ESTs for BACH2:

    AA740709 AA766300 AA831956 AA885077 AA972214 AI051668 AI373181 AI524722 AW014002 N63938 

    Unigene Clusters for BACH2:

    BTB and CNC homology 1, basic leucine zipper transcription factor 2
    Hs.269764  [show with all ESTs], Hs.716609  [show with all ESTs]
    Unigene Representative Sequences: AL512739, NM_021813


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for BACH2

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                            -                     
    SP2:        -     -                             -                     
    SP3:                                                                  

    About this scheme

    ECgene alternative splicing isoforms for BACH2

    3 Ensembl transcripts including schematic representations:
    ENST00000257749  ENST00000343122  ENST00000406998  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    BACH2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for BACH2

    1 / 2 / 3

    9 probe-sets matching BACH2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    51953_at2, 3 U95-B 1 1.00 1.00 0.96 0.89 N63938 0.80 1.00 0.91 1
    87750_at2, 3 U95-E 1 1.00 1.00 0.80 0.75 AW014002 0.80 1.00 0.91 1

    43615_at2, 3 U95-B 1 1.00 1.00 0.50 0.93 AA766300 0.80 1.00 0.91 1
    76811_r_at2, 3 U95-E 1 1.00 1.00 0.85 1.04 AA740709 0.80 1.00 0.91 1

    74614_at2, 3 U95-E 1 0.94 1.00 0.89 1.42 AA825702 0.60 1.00 0.82 1

    227173_s_at2, 3 U133-B 1 1.00 1.00 -- -- AW450901 0.60 1.00 0.82 1

    221234_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_021813 0.60 1.00 0.82 1

    227173_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    221234_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  BACH2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TCCTTTAGAA

    SOURCE GeneReport for Unigene clusters: Hs.269764 Hs.716609

    UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9
    Tissue specificity: B-cell specific

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for BACH2 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    BACH21   -- BTB and CNC homology 1, basic leucine zipper transcription more 92.13(n)
    94.04(a)
    481923  XM_539044.2  XP_539044.2 
    cow
    (Bos taurus)
    BACH21   -- BTB and CNC homology 1, basic leucine zipper transcription more 90.92(n)
    94.05(a)
    538296  XM_618496.3  XP_618496.2 
    rat
    (Rattus norvegicus)
    RGD15628651   -- similar to BTB and CNC homology 1, basic leucine zipper more 87.59(n)
    90.45(a)
    313125  XM_232858.4  XP_232858.3 
    mouse
    (Mus musculus)
    Bach25 4 BTB and CNC homology 2   -- D86604 
    chicken
    (Gallus gallus)
    BACH21   -- BTB and CNC homology 1, basic leucine zipper transcription more 79.91(n)
    81.41(a)
    421809  XM_419833.2  XP_419833.2 
    About this table        Species with no ortholog for BACH2

    ENSEMBL Gene Tree for BACH2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for BACH2 gene
    BACH12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1629 NCBI SNPs in BACH2 are shown (see all 1629 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 565)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs10652721,2
    A,C,F,H,O90695274(-) TATTTA/CTCTTC 1 -- ut31 ese324Minor allele frequency- N:0.00NA EA MN EU WA 2360
    rs104555121,2
    A,C,F,H90698243(+) GACCAT/CGTTAA 1 -- ut3112Minor allele frequency- C:0.23EU EA WA NA 1048
    rs10652731,2
    A,C,F,H90695111(-) CCTTAT/CATTGC 1 -- ut3126Minor allele frequency- C:0.47NA EA MN EU WA 4018
    rs10554031,2
    A,C,F,H90695684(-) CAGTAC/TAGTAA 1 -- ut31 ese321Minor allele frequency- T:0.15NA EA MN EU WA 2152
    rs37346601,2
    A,C,F,H90973066(-) CAAGAA/GCTTCC 1 -- ut5113Minor allele frequency- G:0.18NA EU EA WA 1158
    rs91111,2
    C,F,H,O91038374(-) CGTTCA/GTTCAC 1 -- ut517Minor allele frequency- G:0.35EU EA WA NA 1492
    rs175132761,2
    C,F,H90694146(+) TAAAAT/CGCACT 1 -- ut31 ese311Minor allele frequency- C:0.02NA EU EA WA 978
    rs22895771,2
    C,F,H90697212(-) TCACCG/AGGAAC 1 -- ut31 ese316Minor allele frequency- A:0.06EA NA EU WA 2878
    rs37987901,2
    C,F,H90694225(-) AACATT/GACTTG 1 -- ut31 ese38Minor allele frequency- G:0.02EA NA EU WA 2058
    rs10556831,2
    C,F,H90696965(-) CAGCCC/TGGCTG 1 -- ut31 ese310Minor allele frequency- T:0.30EA MN EU WA 2284
    About this table

    HapMap Linkage Disequilibrium images for BACH2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 605394

    4 Novoseek disease relationships for BACH2 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 46.01 1 12829606 (1)
    lymphoma non-hodgkins 24.11 2 11746976 (1), 10949928 (1)
    leukemia 9.20 2 12829606 (1), 17383980 (1)
    tumors 0.00 1 11746976 (1)
    About this table

    1 PharmGKB disease relationship for BACH2 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12730115
    About this table

    Human Genome Epidemiology Navigator: BACH2 (3 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/34 PubMed articles for BACH2 gene (see all 34 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 60468 HGNC: 14078 AceView: BACH2 Ensembl:ENSG00000112182 euGenes: HUgn60468
    ECgene: BACH2 H-InvDB: BACH2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for BACH2 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for BACH2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for BACH2 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for BACH2 Browse small molecules at Sigma-Aldrich
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     Purified proteins from HEK293T cells
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     shRNA in GFP-retroviral vector
     Search Tocris compounds for BACH2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for BACH2

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