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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BACH2 Gene

protein-coding GIFtS: 54
GCID: GC06M090636

BTB and CNC homology 1, basic leucine zipper transcription...

Explore 12 diseases affiliated with
BACH2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
BTB And CNC Homology 1, Basic Leucine Zipper Transcription Factor 2¹ ²
BTBD25¹ ²
BTB And CNC Homolog 2² ³
Transcription Regulator Protein BACH2²

External Ids:	HGNC: 14078¹	Entrez Gene: 60468²	Ensembl: ENSG00000112182⁷	OMIM: 605394⁵	UniProtKB: Q9BYV9³

Export aliases for BACH2 gene to outside databases

Previous GC identifers: GC06M090582 GC06M090631 GC06M090692 GC06M087855

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9

Function: Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play

important roles in coordinating transcription activation and repression by MAFK (By similarity)

Gene Wiki entry for BACH2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007299.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BACH2 gene promoter:
E2F-4 E2F-3a E2F-5 AP-1 ATF-2 E2F-2 S8 E2F E2F-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BACH2 promoter sequence

Search SABiosciences Chromatin IP Primers for BACH2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BACH2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q15

BACH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BACH2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M090636: view genomic region (about GC identifiers)

Start:	90,636,247 bp from pter	End:	91,006,627 bp from pter
Size:	370,381 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9 (See protein sequence)

Recommended Name: Transcription regulator protein BACH2

Size: 841 amino acids; 92537 Da

Subunit: Heterodimer of BACH2 and Maf-related transcription factors (By similarity)

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=BAD92126.1; Type=Erroneous initiation;

2 PDB 3D structures from and Proteopedia for BACH2:

3OHU (3D)

3OHV (3D)

Secondary accessions: E1P518 Q59H70 Q5T793 Q9NTS5

Explore the universe of human proteins at neXtProt for BACH2: NX_Q9BYV9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BYV9

BACH2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001164265.1 NP_068585.1

ENSEMBL proteins:

ENSP00000257749 ENSP00000345642 ENSP00000384145 ENSP00000397668 ENSP00000437473

Human Recombinant Protein Products for BACH2:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for BACH2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

BACH2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for BACH2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BACH2 for domains About GeneDecksing

5 InterPro domains/families:

IPR004827 bZIP

IPR011333 BTB/POZ_fold

IPR008917 Euk_TF_DNA-bd

IPR013069 BTB_POZ

IPR000210 BTB/POZ-like

Graphical View of Domain Structure for InterPro Entry Q9BYV9

ProtoNet protein and cluster: Q9BYV9

2 Blocks protein families:

IPB000210 BTB/POZ domain

IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9

Similarity: Belongs to the bZIP family. CNC subfamily

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 1 bZIP (basic-leucine zipper) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: BACH2_HUMAN, Q9BYV9

Function: Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play

important roles in coordinating transcription activation and repression by MAFK (By similarity)

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	--	--
GO:0043565	sequence-specific DNA binding	IEA	--
GO:0046983	protein dimerization activity	--	--

BACH2 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for BACH2:

Decreased influenza A/WSN/33 r

Increased gamma-H2AX phosphory

Synthetic lethal with Ras

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Bach2):

cellular

hematopoietic system

immune system

BACH2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Bach2^tm1Igar for BACH2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for BACH2

miRNA Products:		OriGene 3'-UTR Clone: BACH2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BACH2
		8/233 QIAGEN miScript miRNA Assays for microRNAs that regulate BACH2 (see all 233):
		hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-376b hsa-miR-4305 hsa-miR-3622b-3p hsa-miR-200b hsa-miR-509-3-5p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BACH2 (see all 4) OriGene shRNA RFP: BACH2 OriGene siRNA: BACH2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BACH2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BACH2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/11 Interacting proteins for BACH2 (Q9BYV9³ ENSP00000257749⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAFK	O60675³, ENSP00000344903⁴	I2D: score=5 STRING: ENSP00000344903
PATZ1	Q9HBE1³, ENSP00000266269⁴	I2D: score=2 STRING: ENSP00000266269
BCL6	P41182³, ENSP00000232014⁴	I2D: score=1 STRING: ENSP00000232014
NCOR2	Q9Y618³, ENSP00000348551⁴	I2D: score=1 STRING: ENSP00000348551
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--

BACH2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BACH2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BACH2
6 Novoseek chemical compound relationships for BACH2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	52.4	3	15060166 (1), 17383980 (1), 9565602 (1)
12-o-tetradecanoylphorbol 13-acetate	43.3	1	15060166 (1)
retinoid	43	1	17383980 (1)
imatinib	41.3	6	11746976 (3), 12829606 (2)
tyrosine	13.7	1	12829606 (1)
oxygen	0	2	12829606 (1), 17018862 (1)

Search CenterWatch for drugs/clinical trials and news about BACH2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BACH2 gene (2 alternative transcripts):

NM_001170794.1 NM_021813.2

Unigene Cluster for BACH2:

BTB and CNC homology 1, basic leucine zipper transcription factor 2

Hs.269764 [show with all ESTs]

Unigene Representative Sequence: NM_021813

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000257749(uc011eab.2) ENST00000343122 ENST00000481150 ENST00000406998

ENST00000453877 ENST00000470301 ENST00000493201 ENST00000472023 ENST00000494747

ENST00000537989(uc003pnw.3 uc010kch.3)

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		8/233 QIAGEN miScript miRNA Assays for microRNAs that regulate BACH2 (see all 233):
		hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-376b hsa-miR-4305 hsa-miR-3622b-3p hsa-miR-200b hsa-miR-509-3-5p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BACH2
		Sirion Biotech Custom design and validation of potent shRNA sequences against BACH2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BACH2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BACH2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BACH2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BACH2

Additional cDNA sequence:

AB208889.1 AF357835.1 AJ271878.1 AK309526.1 AL512739.1 BC070239.1

11 DOTS entries:

DT.428799 DT.100749486 DT.91825307 DT.75102397 DT.100700979 DT.95163395 DT.97838050 DT.100701438

DT.100727669 DT.91746418 DT.75111577

24/91 AceView cDNA sequences (see all 91):

AA721741 BQ421487 AA748480 AA737041 H91131 BQ187418 Z43962 AI471915

Z40021 AI187096 AL512739 BP366626 AI741097 AL157663 AA279411 AA703557

AA651948 CD522675 N69928 BF514990 AF357835 AA832164 AW967480 BE645870

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for BACH2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10
SP1:															-
SP2:			-		-										-
SP3:

ECgene alternative splicing isoforms for BACH2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BACH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCACCTCTAG

About this image

BACH2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Endocardium

Cushion Mesenchymal Cells

Endocardium

Kidney

Comma-shaped Body

Comma-shaped Body Cells

Kidney

Kidney

Brain

Kidney

Kidney

Kidney

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Primordial germ cell-like cells (Reconstitution of mo...)

See BACH2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BACH2

SOURCE GeneReport for Unigene cluster: Hs.269764

UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9

Tissue specificity: B-cell specific

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for BACH2 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BACH2¹	BTB and CNC homology 1, basic leucine zipper transcription more	79.87(n) 81.41(a)		421809 XM_419833.2 XP_419833.2
lizard (Anolis carolinensis)	Reptilia	BACH2⁶	--	79(a)	1 ↔ 1	1(174538179-174604859)
African clawed frog (Xenopus laevis)	Amphibia	BJ053249.1²	--	82.63(n)		BJ053249.1
zebrafish (Danio rerio)	Actinopterygii	bach2b¹	BTB and CNC homology 1, basic leucine zipper transcription more	64.98(n) 62.71(a)		555350 XM_677841.2 XP_682933.2
fruit fly (Drosophila melanogaster)	Insecta	cnc⁶	cap-n-collar	6(a)	1 → many	3R(19011302-19052430)

ENSEMBL Gene Tree for BACH2 (if available)
TreeFam Gene Tree for BACH2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BACH2 gene

NFE2L1² NFE2L3² BACH1² NFE2² NFE2L2²

18/46 SIMAP similar genes for BACH2 using alignment to 2 protein entries: BACH2_HUMAN (see all proteins) (see all similar genes):

KLHL32 ZBTB7C KLHL3 KLHL14 KLHL36 ZBTB10

KLHL12 KLHL17 ZNF131 BCL6 KLHL2 ZBTB17

ZBTB20 ZBTB8B KLHL15 ZBTB3 ZBTB42 BACH1

BACH2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191801408^1,2		--	90635766(+)	`ACAACA/GTACCC`	2	--	int¹ ds500¹		0	--	--	--	--
rs73492607^1,2	C	--	90635868(+)	`ATGTTC/GTTTCT`	2	--	ds500¹ int¹		2		WA	120
rs149807735^1,2		--	90635992(+)	`TCTGCA/GTAGCG`	2	--	int¹ ds500¹		0	--	--	--	--
rs147897846^1,2		--	90636017(+)	`AAACCA/GAGAAA`	2	--	int¹ ds500¹		0	--	--	--	--
rs73492610^1,2	C	--	90636035(+)	`TAAAGC/TCTTTT`	2	--	int¹ ds500¹		1		WA	2
rs183477491^1,2		--	90636041(+)	`CTTTTA/GTCTAC`	2	--	int¹ ds500¹		0	--	--	--	--
rs114115002^1,2	F	--	90636124(+)	`CCTAAT/CCAGAT`	2	--	ds500¹ int¹		1		WA	118
rs186996113^1,2		--	90636191(+)	`AAAGAA/TTTCCT`	2	--	int¹ ds500¹		0	--	--	--	--
rs145472587^1,2	C	--	90636410(+)	`AATGC-/TTTTTT`	2	--	ut3¹		0	--	--	--	--
rs200683305^1,2	C	--	90636417(-)	`TGGGGA/GAAAAA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BACH2 (90636247 - 90886247 bp, first 250kb of BACH2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for BACH2
2 CNVs: 99624 69565
1 Indel: 40887

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BACH2

DNA2.0 Custom Variant and Variant Library Synthesis for BACH2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BACH2 for disorders           About GeneDecksing

OMIM gene information: 605394    OMIM disorders: --

12 diseases for BACH2:    About MalaCards

non-hodgkin lymphoma hodgkin's lymphoma fanconi's anemia burkitt's lymphoma

celiac disease crohn's disease anemia leukemia

ovarian cancer prostate cancer prostatitis arthritis

4 Novoseek disease relationships for BACH2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia chronic	45.1	1	12829606 (1)
lymphoma non-hodgkins	23.3	2	11746976 (1), 10949928 (1)
leukemia	8.36	2	12829606 (1), 17383980 (1)
tumors	0	1	11746976 (1)

Human Genome Epidemiology (HuGE) Navigator: BACH2 (8 documents)

Export disorders for BACH2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BACH2 gene, integrated from 9 sources (see all 53):
(articles sorted by number of sources associating them with BACH2)

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Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15. (PubMed id 10949928)^{1, 2, 3, 9} Sasaki S.... Yokoyama M. (2000)
Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene. (PubMed id 11746976)^{1, 2, 9} Vieira S.A.D.... Melo J.V. (2001)
B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs. (PubMed id 12829606)^{1, 3, 9} Kamio T....Ito E. (2003)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression. (PubMed id 17383980)^{1, 9} Hoshino H....Yoshida M. (2007)
Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6. (PubMed id 18256039)^{1, 9} Ochiai K....Igarashi K. (2008)
The role of Bach2 in nucleic acid-triggered antiviral innate immune responses. (PubMed id 17991429)^{1, 9} Hong S.W....Lee D.K. (2008)
Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2. (PubMed id 15060166)^{1, 9} Tashiro S....Igarashi K. (2004)
Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1. (PubMed id 17018862)^{1, 9} Yoshida C....Melo J.V. (2007)
Genome-wide association analyses identify 13 new susce ptibility loci for generalized vitiligo. (PubMed id 22561518)¹ Jin Y....Spritz R.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 60468	HGNC: 14078	AceView: BACH2	Ensembl:ENSG00000112182	euGenes: HUgn60468
ECgene: BACH2	H-InvDB: BACH2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for BACH2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BACH2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for BACH2 gene
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Patent Information for BACH2 gene:
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