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BACH2 Gene

protein-coding   GIFtS: 58
GCID: GC06M090636

BTB And CNC Homology 1, Basic Leucine Zipper Transcription...

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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BTB And CNC Homology 1, Basic Leucine Zipper Transcription Factor 21 2
BTB And CNC Homolog 22 3
BTBD252
Transcription Regulator Protein BACH22

External Ids:    HGNC: 140781   Entrez Gene: 604682   Ensembl: ENSG000001121827   OMIM: 6053945   UniProtKB: Q9BYV93   

Export aliases for BACH2 gene to outside databases

Previous GC identifers: GC06M090582 GC06M090631 GC06M090692 GC06M087855


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BACH2 Gene:
BACH2 (BTB and CNC homology 1, basic leucine zipper transcription factor 2) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NFE2L3.

UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9
Function: Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE).
Play important roles in coordinating transcription activation and repression by MAFK (By similarity). Induces
apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1

Gene Wiki entry for BACH2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BACH2 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   ATF-2   E2F-2   S8   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBACH2 promoter sequence
   Search Chromatin IP Primers for BACH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BACH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q15

BACH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BACH2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M090636:  view genomic region     (about GC identifiers)

Start:
90,636,247 bp from pter      End:
91,006,627 bp from pter
Size:
370,381 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9 (See protein sequence)
Recommended Name: Transcription regulator protein BACH2  
Size: 841 amino acids; 92537 Da
Subunit: Heterodimer of BACH2 and Maf-related transcription factors (By similarity). Homodimer; disulfide-linked
Sequence caution: Sequence=BAD92126.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for BACH2:
3OHU (3D)        3OHV (3D)    
Secondary accessions: E1P518 Q59H70 Q5T793 Q9NTS5

Explore the universe of human proteins at neXtProt for BACH2: NX_Q9BYV9

Explore proteomics data for BACH2 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export1
  • The reversible disulfide bond may provide mechanism to regulate the activity in oxidative stress responses1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BACH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001164265.1  NP_068585.1  

    ENSEMBL proteins: 
     ENSP00000257749   ENSP00000345642   ENSP00000384145   ENSP00000397668   ENSP00000437473  

    BACH2 Human Recombinant Protein Products:

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    Novus Biologicals BACH2 Protein
    Novus Biologicals BACH2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for BACH2

     
    Search eBioscience for Proteins for BACH2 

    BACH2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BACH2
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    Cloud-Clone Corp. ELISAs for BACH2
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    Search eBioscience for ELISAs for BACH2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    bZIP: basic leucine zipper proteins

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR004827 bZIP
     IPR011333 BTB/POZ_fold
     IPR008917 TF_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q9BYV9

    ProtoNet protein and cluster: Q9BYV9

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9
    Similarity: Belongs to the bZIP family. CNC subfamily
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with BACH2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BACH2_HUMAN, Q9BYV9
    Function: Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE).
    Play important roles in coordinating transcription activation and repression by MAFK (By similarity). Induces
    apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with BACH2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for BACH2:
     Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bach2):
     hematopoietic system  immune system 

    Find genes that share phenotypes with BACH2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bach2tm1Igar for BACH2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BACH2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BACH2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BACH2

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  TGCTGAGTCA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target BACH2:
    hsa-mir-335-5p (MIRT018572), hsa-mir-29c-3p (MIRT020413), hsa-mir-615-3p (MIRT039735)

    Block miRNA regulation of human, mouse, rat BACH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BACH2 (see all 233):
    hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-376b hsa-miR-4305 hsa-miR-3622b-3p hsa-miR-200b hsa-miR-509-3-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BACH2

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BACH2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BACH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BACH2_HUMAN, Q9BYV9: Cytoplasm. Nucleus. Note=Nucleocytoplasmic shuttling is controlled by phosphorylation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with BACH2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BACH2 About    
    See pathways by source

    SuperPathContained pathways About
    1Lymphocyte Signaling
    Lymphocyte Signaling


    Find genes that share SuperPaths with BACH2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for BACH2
        Lymphocyte Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BACH2
    Interactions:

        GeneGlobe Interaction Network for BACH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for BACH2 (Q9BYV93 ENSP000002577494) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAFKO606753, ENSP000003449034I2D: score=5 STRING: ENSP00000344903
    BCL6P411823, ENSP000002320144I2D: score=1 STRING: ENSP00000232014
    NCOR2Q9Y6183, ENSP000003485514I2D: score=1 STRING: ENSP00000348551
    PATZ1Q9HBE13, ENSP000002662694I2D: score=2 STRING: ENSP00000266269
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with BACH2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BACH2

    6 Novoseek inferred chemical compound relationships for BACH2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 52.4 3 15060166 (1), 17383980 (1), 9565602 (1)
    12-o-tetradecanoylphorbol 13-acetate 43.3 1 15060166 (1)
    retinoid 43 1 17383980 (1)
    imatinib 41.3 6 11746976 (3), 12829606 (2)
    tyrosine 13.7 1 12829606 (1)
    oxygen 0 2 12829606 (1), 17018862 (1)



    Find genes that share compounds with BACH2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BACH2 gene (2 alternative transcripts): 
    NM_001170794.1  NM_021813.2  

    Unigene Cluster for BACH2:

    BTB and CNC homology 1, basic leucine zipper transcription factor 2
    Hs.269764  [show with all ESTs]
    Unigene Representative Sequence: NM_021813
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257749(uc011eab.2) ENST00000343122 ENST00000481150 ENST00000406998
    ENST00000453877 ENST00000470301 ENST00000493201 ENST00000472023 ENST00000494747
    ENST00000537989(uc003pnw.3 uc010kch.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat BACH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BACH2 (see all 233):
    hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-376b hsa-miR-4305 hsa-miR-3622b-3p hsa-miR-200b hsa-miR-509-3-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BACH2 (NM_001170794)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BACH2
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat BACH2

    Additional mRNA sequence: 

    AB208889.1 AF357835.1 AJ271878.1 AK309526.1 AL512739.1 BC070239.1 

    11 DOTS entries:

    DT.428799  DT.100749486  DT.91825307  DT.75102397  DT.100700979  DT.95163395  DT.97838050  DT.100701438 
    DT.100727669  DT.91746418  DT.75111577 

    Selected AceView cDNA sequences (see all 91):

    AL512739 AI187096 Z40021 AA721741 H91131 AI471915 AA748480 BQ421487 
    BQ187418 Z43962 AA737041 BP366626 AL157663 AI741097 CD522675 AA279411 
    AA703557 AA651948 AA488974 AW505021 AI004995 AI377645 CF143478 CF138546 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for BACH2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                            -                     
    SP2:        -     -                             -                     
    SP3:                                                                  


    ECgene alternative splicing isoforms for BACH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BACH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACCTCTAG
    BACH2 Expression
    About this image


    BACH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             S-shaped Body Cells S-shaped Body
             S-shaped Body
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Heart (Cardiovascular System)
             Cushion Mesenchymal Cells Endocardium
     
     Neural Tube (Nervous System)
             Telencephalon
    BACH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BACH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.269764

    UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9
    Tissue specificity: B-cell specific

        Custom PCR Arrays for BACH2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BACH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BACH2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bach21 , 5 BTB and CNC homology 21, 5 87.95(n)1
    90.33(a)1
      4 (14.02 cM)5
    120141  NM_001109661.11  NP_001103131.11 
     322388045 
    chicken
    (Gallus gallus)
    Aves BACH21 BTB and CNC homology 1, basic leucine zipper transcription more 79.83(n)
    81.29(a)
      421809  XM_419833.3  XP_419833.2 
    lizard
    (Anolis carolinensis)
    Reptilia BACH26
    BTB and CNC homology 1, basic leucine zipper trans...
    79(a)
    1 ↔ 1
    1(174493829-174604859)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ053249.12   -- 82.63(n)    BJ053249.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bach2b1 BTB and CNC homology 1, basic leucine zipper transcription more 64.48(n)
    61.62(a)
      555350  XM_005160548.1  XP_005160605.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cnc6
    cap-n-collar
    9(a)
    1 → many
    3R(19011302-19052430)


    ENSEMBL Gene Tree for BACH2 (if available)
    TreeFam Gene Tree for BACH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BACH2 gene
    NFE2L32  BACH12  NFE2L12  NFE22  NFE2L22  
    Selected SIMAP similar genes for BACH2 using alignment to 2 protein entries:     BACH2_HUMAN (see all proteins) (see all similar genes):
    Bach2    KLHL32    ZBTB7C    KLHL3    KLHL14    KLHL36
    ZBTB10    KLHL12    KLHL17    ZNF131    BCL6    KLHL2
    ZBTB17    ZBTB20    ZBTB8B    KLHL15    ZBTB3    ZBTB42

    Find genes that share paralogs with BACH2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BACH2 (see all 6810)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs350544431,2
    C--87883564(+) TTTTT-/T/TT  
            
    GATGC
    2 -- int11NA 2
    rs1918014081,2
    --90635766(+) ACAACA/GTACCC 2 -- int1 ds50010--------
    rs734926071,2
    C,F--90635868(+) ATGTTC/GTTTCT 2 -- int1 ds50012Minor allele frequency- G:0.03WA 120
    rs1498077351,2
    C--90635992(+) TCTGCA/GTAGCG 2 -- int1 ds50010--------
    rs1478978461,2
    C--90636017(+) AAACCA/GAGAAA 2 -- int1 ds50010--------
    rs734926101,2
    C,F--90636035(+) TAAAGC/TCTTTT 2 -- int1 ds50011Minor allele frequency- T:0.50WA 2
    rs1834774911,2
    --90636041(+) CTTTTA/GTCTAC 2 -- int1 ds50010--------
    rs1141150021,2
    F--90636124(+) CCTAAT/CCAGAT 2 -- int1 ds50011Minor allele frequency- C:0.03WA 118
    rs1869961131,2
    --90636191(+) AAAGAA/TTTCCT 2 -- int1 ds50010--------
    rs1454725871,2
    C--90636410(+) TTTTT-/TCCCCC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for BACH2 (90636247 - 90886247 bp, first 250kb of BACH2)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for BACH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2499312CNV Deletion19546169
    esv268972CNV Insertion20981092
    esv273328CNV Insertion20981092
    esv270781CNV Insertion20981092
    esv28039CNV Loss19812545
    esv275360CNV Gain+Loss21479260

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for BACH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605394    OMIM disorders: --


    Find genes that share disorders with BACH2           About GenesLikeMe

    4 Novoseek inferred disease relationships for BACH2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 45.1 1 12829606 (1)
    lymphoma non-hodgkins 23.3 2 11746976 (1), 10949928 (1)
    leukemia 8.36 2 12829606 (1), 17383980 (1)
    tumors 0 1 11746976 (1)

    Genetic Association Database (GAD): BACH2
    Human Genome Epidemiology (HuGE) Navigator: BACH2 (8 documents)

    Export disorders for BACH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BACH2 gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with BACH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15. (PubMed id 10949928)1, 2, 3, 9 Sasaki S.... Yokoyama M. (Oncogene 2000)
    2. Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene. (PubMed id 11746976)1, 2, 9 Vieira S.A.D.... Melo J.V. (Genes Chromosomes Cancer 2001)
    3. B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs. (PubMed id 12829606)1, 3, 9 Kamio T....Ito E. (Blood 2003)
    4. Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1. (PubMed id 17018862)1, 2, 9 Yoshida C....Melo J.V. (Blood 2007)
    5. The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond. (PubMed id 22194330)1, 2 Rosbrook G.O....Wright S.C. (Acta Crystallogr. D Biol. Crystallogr. 2012)
    6. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PubMed id 21829393)1, 4 Plagnol V....Todd J.A. (PLoS Genet. 2011)
    7. A genome-wide association study identifies two new risk loci for Graves' disease. (PubMed id 21841780)1, 4 Chu X....Song H.D. (Nat. Genet. 2011)
    8. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (Nature 2011)
    9. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    10. Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk. (PubMed id 20203524)1, 4 Pierce B.L. and Ahsan H. (Hum. Hered. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 60468 HGNC: 14078 AceView: BACH2 Ensembl:ENSG00000112182 euGenes: HUgn60468
    ECgene: BACH2 H-InvDB: BACH2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BACH2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BACH2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BACH2 gene:
    Search GeneIP for patents involving BACH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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