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Aliases for BACH2 Gene

Aliases for BACH2 Gene

  • BTB Domain And CNC Homolog 2 2 3
  • BTB And CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 2 3 5
  • BTB And CNC Homolog 2 3 4
  • BTBD25 3

External Ids for BACH2 Gene

Previous GeneCards Identifiers for BACH2 Gene

  • GC06M090582
  • GC06M090631
  • GC06M090692
  • GC06M087855
  • GC06M090636

Summaries for BACH2 Gene

GeneCards Summary for BACH2 Gene

BACH2 (BTB Domain And CNC Homolog 2) is a Protein Coding gene. Diseases associated with BACH2 include leukemia, chronic myeloid, somatic and lymphoma, non-hodgkin. Among its related pathways are NF-kappaB Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II distal enhancer sequence-specific DNA binding. An important paralog of this gene is NFE2.

UniProtKB/Swiss-Prot for BACH2 Gene

  • Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1.

Gene Wiki entry for BACH2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BACH2 Gene

Genomics for BACH2 Gene

Regulatory Elements for BACH2 Gene

Enhancers for BACH2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BACH2 on UCSC Golden Path with GeneCards custom track

Promoters for BACH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BACH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BACH2 Gene

Chromosome:
6
Start:
89,926,528 bp from pter
End:
90,296,908 bp from pter
Size:
370,381 bases
Orientation:
Minus strand

Genomic View for BACH2 Gene

Genes around BACH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BACH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BACH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BACH2 Gene

Proteins for BACH2 Gene

  • Protein details for BACH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYV9-BACH2_HUMAN
    Recommended name:
    Transcription regulator protein BACH2
    Protein Accession:
    Q9BYV9
    Secondary Accessions:
    • E1P518
    • Q59H70
    • Q5T793
    • Q9NTS5

    Protein attributes for BACH2 Gene

    Size:
    841 amino acids
    Molecular mass:
    92537 Da
    Quaternary structure:
    • Heterodimer of BACH2 and Maf-related transcription factors (By similarity). Homodimer; disulfide-linked.
    SequenceCaution:
    • Sequence=BAD92126.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BACH2 Gene

neXtProt entry for BACH2 Gene

Proteomics data for BACH2 Gene at MOPED

Post-translational modifications for BACH2 Gene

  • Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export.
  • The reversible disulfide bond may provide mechanism to regulate the activity in oxidative stress responses.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BACH2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BACH2 (BACH2)

No data available for DME Specific Peptides for BACH2 Gene

Domains & Families for BACH2 Gene

Protein Domains for BACH2 Gene

Suggested Antigen Peptide Sequences for BACH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYV9

UniProtKB/Swiss-Prot:

BACH2_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Belongs to the bZIP family. CNC subfamily.
Domain:
  • Contains 1 BTB (POZ) domain.
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. CNC subfamily.
genes like me logo Genes that share domains with BACH2: view

Function for BACH2 Gene

Molecular function for BACH2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1.

Gene Ontology (GO) - Molecular Function for BACH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding IEA --
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with BACH2: view
genes like me logo Genes that share phenotypes with BACH2: view

Animal Models for BACH2 Gene

MGI Knock Outs for BACH2:

Animal Model Products

miRNA for BACH2 Gene

Transcription Factor Targets for BACH2 Gene

Selected GeneGlobe predicted Target genes for BACH2
Targeted motifs for BACH2 Gene
HOMER Transcription Factor Regulatory Elements motif BACH2
  • Consensus sequence: TGCTGAGTCA Submotif: canonical Cell Type: OCILy7 GEO ID: GSE44420

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for BACH2 Gene

Localization for BACH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BACH2 Gene

Cytoplasm. Nucleus. Note=Nucleocytoplasmic shuttling is controlled by phosphorylation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BACH2 Gene COMPARTMENTS Subcellular localization image for BACH2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for BACH2 Gene

Pathways & Interactions for BACH2 Gene

SuperPathways for BACH2 Gene

Superpath Contained pathways
1 NF-kappaB Signaling
genes like me logo Genes that share pathways with BACH2: view

Pathways by source for BACH2 Gene

1 Cell Signaling Technology pathway for BACH2 Gene

Gene Ontology (GO) - Biological Process for BACH2 Gene

None

No data available for SIGNOR curated interactions for BACH2 Gene

Drugs & Compounds for BACH2 Gene

(3) Drugs for BACH2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for BACH2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BACH2: view

Transcripts for BACH2 Gene

Unigene Clusters for BACH2 Gene

BTB and CNC homology 1, basic leucine zipper transcription factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BACH2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - - -
SP3:

Relevant External Links for BACH2 Gene

GeneLoc Exon Structure for
BACH2
ECgene alternative splicing isoforms for
BACH2

Expression for BACH2 Gene

mRNA expression in normal human tissues for BACH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BACH2 Gene

This gene is overexpressed in Platelet (32.2), Blymphocyte (18.9), and Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BACH2 Gene



SOURCE GeneReport for Unigene cluster for BACH2 Gene Hs.269764

mRNA Expression by UniProt/SwissProt for BACH2 Gene

Q9BYV9-BACH2_HUMAN
Tissue specificity: B-cell specific.
genes like me logo Genes that share expression patterns with BACH2: view

Protein tissue co-expression partners for BACH2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for BACH2 Gene

Orthologs for BACH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BACH2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BACH2 35
  • 90.61 (n)
  • 93.58 (a)
BACH2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BACH2 35
  • 91.62 (n)
  • 92.85 (a)
BACH2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bach2 35
  • 87.95 (n)
  • 90.33 (a)
Bach2 16
Bach2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BACH2 35
  • 99.08 (n)
  • 99.39 (a)
BACH2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562865 35
  • 87.51 (n)
  • 90.33 (a)
oppossum
(Monodelphis domestica)
Mammalia BACH2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
ManyToMany
chicken
(Gallus gallus)
Aves BACH2 35
  • 79.83 (n)
  • 81.29 (a)
BACH2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BACH2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bach2 35
  • 73.08 (n)
  • 74.85 (a)
zebrafish
(Danio rerio)
Actinopterygii bach2b 35
  • 64.48 (n)
  • 61.62 (a)
bach2b 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cnc 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for BACH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BACH2 Gene

ENSEMBL:
Gene Tree for BACH2 (if available)
TreeFam:
Gene Tree for BACH2 (if available)

Paralogs for BACH2 Gene

Paralogs for BACH2 Gene

genes like me logo Genes that share paralogs with BACH2: view

Variants for BACH2 Gene

Sequence variations from dbSNP and Humsavar for BACH2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs34335140 - 89,950,854(-) TGGAG(A/G)CTCTC reference, missense
rs1010473 -- 90,147,159(+) GAAGG(G/T)GCAGT intron-variant
rs1010474 -- 90,147,309(+) TTTTC(C/T)GCCAC intron-variant
rs1018525 -- 90,226,649(-) AATAG(A/G)AGACA intron-variant
rs1055403 -- 89,929,244(-) CAGTA(C/T)AGTAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BACH2 Gene

Variant ID Type Subtype PubMed ID
esv273328 CNV Insertion 20981092
esv268972 CNV Insertion 20981092
esv275360 CNV Gain+Loss 21479260
esv270781 CNV Insertion 20981092
esv2499312 CNV Deletion 19546169
esv28039 CNV Loss 19812545

Variation tolerance for BACH2 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BACH2 Gene

HapMap Linkage Disequilibrium report
BACH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BACH2 Gene

Disorders for BACH2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BACH2 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
leukemia, chronic myeloid, somatic
  • chronic myeloid leukemia
lymphoma, non-hodgkin
  • lymphoma, non-hodgkin, somatic
- elite association - COSMIC cancer census association via MalaCards
Search BACH2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BACH2

Genetic Association Database (GAD)
BACH2
Human Genome Epidemiology (HuGE) Navigator
BACH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BACH2
genes like me logo Genes that share disorders with BACH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BACH2 Gene

Publications for BACH2 Gene

  1. Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15. (PMID: 10949928) Sasaki S. … Yokoyama M. (Oncogene 2000) 2 3 4 23 67
  2. B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs. (PMID: 12829606) Kamio T. … Ito E. (Blood 2003) 2 3 23
  3. The role of Bach2 in nucleic acid-triggered antiviral innate immune responses. (PMID: 17991429) Hong S.W. … Lee D.K. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6. (PMID: 18256039) Ochiai K. … Igarashi K. (Int. Immunol. 2008) 3 23
  5. Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1. (PMID: 17018862) Yoshida C. … Melo J.V. (Blood 2007) 3 23

Products for BACH2 Gene

Sources for BACH2 Gene

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