Aliases for BACH2 Gene
Aliases for BACH2 Gene
External Ids for BACH2 Gene
- HGNC: 14078
- Entrez Gene: 60468
- Ensembl: ENSG00000112182
- OMIM: 605394
- UniProtKB: Q9BYV9
Previous GeneCards Identifiers for BACH2 Gene
- GC06M090582
- GC06M090631
- GC06M090692
- GC06M087855
- GC06M090636
Summaries for BACH2 Gene
GeneCards Summary for BACH2 Gene
BACH2 (BTB Domain And CNC Homolog 2) is a Protein Coding gene. Diseases associated with BACH2 include Lymphoma, Non-Hodgkin and Leukemia, Chronic Myeloid, Somatic. Among its related pathways are NF-kappaB Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II distal enhancer sequence-specific DNA binding. An important paralog of this gene is GRIK1-AS2.
UniProtKB/Swiss-Prot for BACH2 Gene
-
Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BACH2 Gene
Genomics for BACH2 Gene
Regulatory Elements for BACH2 Gene
Enhancers for BACH2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G090283 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 22 | +11.5 | 11480 | 3.5 | PKNOX1 ATF1 SIN3A ZNF2 ELK1 GATA2 CBX5 ZNF416 ZNF143 FOS | BACH2 ENSG00000226455 MDN1 LOC105377890 |
| GH06G090271 | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 20.2 | +22.8 | 22812 | 5.5 | SCRT1 CTCF MTA2 FEZF1 TBX21 RAD21 ZSCAN21 PRDM6 SCRT2 ZXDB | BACH2 MDN1 LOC105377890 |
| GH06G090214 | 2.6 | Ensembl ENCODE dbSUPER | 11.7 | +78.9 | 78908 | 6.2 | FOXA2 PKNOX1 SIN3A FEZF1 ZNF2 YY1 FOS ZNF263 SP3 REST | MDN1 BACH2 CASP8AP2 LOC105377890 |
| GH06G090292 | 1.6 | FANTOM5 ENCODE dbSUPER | 18.2 | +1.4 | 1383 | 5.3 | FOXA2 ATF1 SIN3A ZNF2 GLIS2 CBX5 KLF13 ZNF263 SP3 TSHZ1 | BACH2 MDN1 LOC105377890 |
| GH06G090135 | 1.5 | Ensembl ENCODE dbSUPER | 10.8 | +160.0 | 160022 | 3.6 | PKNOX1 ATF1 ZNF133 FEZF1 GLI4 ZNF2 FOS KLF7 ZNF548 ZNF263 | CASP8AP2 BACH2 ENSG00000218730 LOC105377890 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around BACH2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for BACH2 Gene
- Chromosome:
- 6
- Start:
- 89,926,528 bp from pter
- End:
- 90,296,908 bp from pter
- Size:
- 370,381 bases
- Orientation:
- Minus strand
Genomic View for BACH2 Gene
Genes around BACH2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q15 by Ensembl
- 6q15 by Entrez Gene
- 6q15 by HGNC
BACH2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BACH2 Gene
Proteins for BACH2 Gene
-
Protein details for BACH2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BYV9-BACH2_HUMAN
- Recommended name:
- Transcription regulator protein BACH2
- Protein Accession:
- Q9BYV9
- E1P518
- Q59H70
- Q5T793
- Q9NTS5
Protein attributes for BACH2 Gene
- Size:
- 841 amino acids
- Molecular mass:
- 92537 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked (PubMed:22194330). Heterodimer of BACH2 and Maf-related transcription factors (By similarity).
- SequenceCaution:
-
- Sequence=BAD92126.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for BACH2 Gene
Post-translational modifications for BACH2 Gene
- Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export.
- The reversible disulfide bond may provide a mechanism to regulate the activity in oxidative stress responses.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for BACH2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for BACH2
- Cell Signaling Technology (CST) Antibodies for BACH2 (BACH2)
-
Custom Antibody ServicesOriGene Antibodies for BACH2
- Novus Biologicals Antibodies for BACH2
- Invitrogen Antibodies for BACH2
- antibodies-online Antibodies for BACH2: See all 72
- Search GeneTex for Antibodies for BACH2
Protein Products
-
OriGene Purified Proteins for BACH2
- Search Origene for MassSpec and Protein Over-expression Lysates for BACH2
- Origene Custom Protein Services for BACH2
- antibodies-online Proteins for BACH2: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for BACH2
Assay Products
No data available for DME Specific Peptides for BACH2 Gene
Domains & Families for BACH2 Gene
Gene Families for BACH2 Gene
Protein Domains for BACH2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for BACH2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BYV9- Family:
-
- Belongs to the bZIP family. CNC subfamily.
Function for BACH2 Gene
Molecular function for BACH2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IBA | -- |
| GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IBA | -- |
| GO:0004842 | contributes_to ubiquitin-protein transferase activity | IBA | -- |
Phenotypes for BACH2 Gene
- MGI mutant phenotypes for BACH2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for BACH2:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Negative genetic interaction between MUS81-/- and MUS81+/+
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased influenza A/WSN/33 replication
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BACH2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for BACH2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BACH2 gene
- Search ViGene Biosciences for BACH2
CRISPR Products
-
OriGene CRISPR knockouts for BACH2
-
Santa Cruz Biotechnology (SCBT) CRISPR for BACH2
- GenScript: Design CRISPR guide RNA sequences for BACH2
miRNA for BACH2 Gene
- miRTarBase miRNAs that target BACH2
-
- hsa-mir-335-5p (MIRT018572)
- hsa-mir-29c-3p (MIRT020413)
- hsa-mir-615-3p (MIRT039735)
- hsa-mir-8064 (MIRT318819)
- hsa-mir-1277-5p (MIRT408867)
- hsa-mir-190a-3p (MIRT508029)
- hsa-mir-6083 (MIRT508030)
- hsa-mir-5011-5p (MIRT508031)
- hsa-mir-656-3p (MIRT543065)
- hsa-mir-410-3p (MIRT543066)
- hsa-mir-3942-3p (MIRT609046)
- hsa-mir-1324 (MIRT609047)
- hsa-mir-8485 (MIRT609048)
- hsa-mir-6797-3p (MIRT624595)
- hsa-mir-6076 (MIRT624596)
- hsa-mir-6807-3p (MIRT624597)
- hsa-mir-217 (MIRT624598)
- hsa-mir-509-5p (MIRT624599)
- hsa-mir-509-3-5p (MIRT624600)
- hsa-mir-4418 (MIRT624601)
- hsa-mir-6749-3p (MIRT660360)
- hsa-mir-211-5p (MIRT660361)
- hsa-mir-204-5p (MIRT660362)
- hsa-mir-2355-5p (MIRT660363)
- hsa-mir-15b-3p (MIRT660364)
- hsa-mir-4685-3p (MIRT660365)
- hsa-mir-4287 (MIRT660366)
- hsa-mir-6832-3p (MIRT660367)
- hsa-mir-620 (MIRT660368)
- hsa-mir-1270 (MIRT660369)
- hsa-mir-4531 (MIRT660370)
- hsa-mir-5703 (MIRT660371)
- hsa-mir-4516 (MIRT660372)
- hsa-mir-4434 (MIRT660373)
- hsa-mir-5695 (MIRT660374)
- hsa-mir-3145-5p (MIRT660375)
- hsa-let-7g-3p (MIRT708178)
- hsa-let-7a-2-3p (MIRT708179)
- hsa-mir-374b-5p (MIRT708180)
- hsa-mir-374a-5p (MIRT708181)
- hsa-mir-4791 (MIRT708182)
- hsa-mir-3201 (MIRT708183)
- hsa-mir-5692c (MIRT708184)
- hsa-mir-5692b (MIRT708185)
- hsa-mir-369-3p (MIRT708186)
- hsa-mir-5583-3p (MIRT708187)
- hsa-mir-4517 (MIRT708188)
- hsa-mir-557 (MIRT719703)
- hsa-mir-507 (MIRT719704)
- hsa-mir-4726-3p (MIRT719705)
- hsa-mir-6764-5p (MIRT719706)
- hsa-mir-1915-3p (MIRT719707)
- hsa-mir-6840-3p (MIRT719708)
Transcription Factor Targets for BACH2 Gene
Targeted motifs for BACH2 Gene
HOMER Transcription Factor Regulatory Elements motif BACH2
- Consensus sequence: TGCTGAGTCA Submotif: canonical Cell Type: OCILy7 GEO ID: GSE44420
miRNA Products
- Search ViGene Biosciences for BACH2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for BACH2
- Browse OriGene Inhibitory RNA Products For BACH2
-
ViGene Biosciences ready-to-package AAV shRNAs for BACH2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for BACH2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BACH2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for BACH2
-
ViGene Biosciences adenoviral particle packaged cDNA for BACH2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for BACH2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BACH2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for BACH2 Gene
Localization for BACH2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BACH2 Gene
- Cytoplasm. Nucleus. Note=Nucleocytoplasmic shuttling is controlled by phosphorylation. {ECO:0000269 PubMed:17018862}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0031463 | Cul3-RING ubiquitin ligase complex | IBA | -- |
Pathways & Interactions for BACH2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | NF-kappaB Signaling | ||
Pathways by source for BACH2 Gene
1 Cell Signaling Technology pathway for BACH2 Gene
Interacting Proteins for BACH2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | IBA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
No data available for SIGNOR curated interactions for BACH2 Gene
Transcripts for BACH2 Gene
mRNA/cDNA for BACH2 Gene
- (18) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (91) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for BACH2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for BACH2
-
Santa Cruz Biotechnology (SCBT) CRISPR for BACH2
- GenScript: Design CRISPR guide RNA sequences for BACH2
miRNA Products
- Search ViGene Biosciences for BACH2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for BACH2
- Browse OriGene Inhibitory RNA Products For BACH2
-
ViGene Biosciences ready-to-package AAV shRNAs for BACH2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for BACH2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BACH2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||
| SP3: |
Expression for BACH2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- S-shaped Body Cells S-shaped Body
- Comma-shaped Body Cells Comma-shaped Body
- Renal Vesicle
- Comma-shaped Body
- S-shaped Body
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
- Mature B-Cells Peripheral Blood
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Heart (Cardiovascular System)
- Cushion Mesenchymal Cells Endocardium
- Brain (Nervous System)
- Neural Tube (Nervous System)
This gene is overexpressed in Platelet (32.2), Blymphocyte (18.9), and Peripheral blood mononuclear cells (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BACH2 Gene
NURSA nuclear receptor signaling pathways regulating expression of BACH2 Gene:
BACH2SOURCE GeneReport for Unigene cluster for BACH2 Gene:
Hs.269764mRNA Expression by UniProt/SwissProt for BACH2 Gene:
Q9BYV9-BACH2_HUMAN
Tissue specificity:
B-cell specific.
Evidence on tissue expression from TISSUES for BACH2 Gene
- Nervous system(4.6)
- Blood(2.4)
- Bone marrow(2.3)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for BACH2
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BACH2 Gene
Orthologs for BACH2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BACH2 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BACH2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | BACH2 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| mouse (Mus musculus) |
Mammalia | Bach2 16 35 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | RGD1562865 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | BACH2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BACH2 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | BACH2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bach2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | bach2b 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | cnc 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for BACH2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for BACH2 Gene
(48) SIMAP similar genes for BACH2 Gene using alignment to 2 proteins:
- Bach2
- KLHL32
- ZBTB7C
- KLHL3
- ZBTB10
- KLHL36
- KLHL14
- KLHL17
- KLHL12
- ZNF131
- BCL6
- KLHL2
- ZBTB8B
- ZBTB20
- ZBTB17
- ZBTB42
- ZBTB3
- KLHL15
- BACH1
- ZBTB14
- NACC1
- ZBTB46
- ZBTB44
- ZBTB38
- ZNF295
- ZBTB21
- HIC1
- DKFZp781N1974
- ZBTB1
- MYNN
- ZBTB22
- ZBTB16
- KLHL29
- KLHL24
- BCL6B
- ZBTB25
- KLHL26
- ZBTB49
- ZBTB4
- KLHL13
- ZBTB48
- ZBTB43
- ZBTB34
- KLHL21
- KLHL28
- KLHL20
- KLHL22
- BTBD18
Variants for BACH2 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000005631 | -- | 90,250,124(+) | CTGAA(C/T)GAAAG | intron-variant | |
| rs1000008812 | -- | 90,079,443(+) | TTTTT(A/T)AAAAA | intron-variant | |
| rs1000016257 | -- | 90,108,239(+) | AGATC(C/T)CAAGG | intron-variant | |
| rs1000017691 | -- | 89,958,011(+) | ATAAA(C/T)GGAGT | intron-variant | |
| rs1000018247 | -- | 90,154,188(+) | AGAAT(A/T)GCAGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10837n54 | CNV | loss | 21841781 |
| esv2499312 | CNV | deletion | 19546169 |
| esv275360 | CNV | gain+loss | 21479260 |
| esv28039 | CNV | loss | 19812545 |
| esv3304694 | CNV | mobile element insertion | 20981092 |
| esv3309055 | CNV | mobile element insertion | 20981092 |
| esv3350061 | CNV | insertion | 20981092 |
| esv3440926 | CNV | insertion | 20981092 |
| esv3449602 | CNV | insertion | 20981092 |
| esv3452003 | CNV | insertion | 20981092 |
| esv3609913 | CNV | loss | 21293372 |
| esv3609914 | CNV | loss | 21293372 |
| esv3609915 | CNV | loss | 21293372 |
| esv3609916 | CNV | loss | 21293372 |
| esv3609919 | CNV | loss | 21293372 |
| esv3890901 | CNV | gain | 25118596 |
| nsv1074419 | CNV | deletion | 25765185 |
| nsv1114853 | CNV | deletion | 24896259 |
| nsv1137125 | CNV | deletion | 24896259 |
| nsv604125 | CNV | gain | 21841781 |
| nsv604126 | CNV | gain | 21841781 |
| nsv604127 | CNV | loss | 21841781 |
| nsv604130 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.54;
44.34% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for BACH2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BACH2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BACH2 Gene
Disorders for BACH2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphoma, non-hodgkin |
|
|
| leukemia, chronic myeloid, somatic |
|
Search BACH2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for BACH2
No data available for UniProtKB/Swiss-Prot and Genatlas for BACH2 Gene
Publications for BACH2 Gene
- Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15. (PMID: 10949928) Sasaki S. … Yokoyama M. (Oncogene 2000) 2 3 4 22 64
- Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1. (PMID: 17018862) Yoshida C. … Melo J.V. (Blood 2007) 3 4 22 64
- B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs. (PMID: 12829606) Kamio T. … Ito E. (Blood 2003) 2 3 22 64
- Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene. (PMID: 11746976) Vieira S.A.D. … Melo J.V. (Genes Chromosomes Cancer 2001) 3 4 22 64
- The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond. (PMID: 22194330) Rosbrook G.O. … Wright S.C. (Acta Crystallogr. D Biol. Crystallogr. 2012) 3 4 64
Products for BACH2 Gene
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- Custom Antibody ServicesOriGene Antibodies for BACH2
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for BACH2
- Browse OriGene Inhibitory RNA Products For BACH2
- OriGene qPCR primer pairs for BACH2
- OriGene CRISPR knockouts for BACH2
- OriGene ORF clones in human for BACH2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BACH2
- GenScript: Next-day shipping cDNA ORF clone for BACH2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for BACH2
- GenScript Custom Assay Services for BACH2
- GenScript Custom overexpressing Cell Line Services for BACH2
- GenScript: Design CRISPR guide RNA sequences for BACH2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for BACH2
- Cell Signaling Technology (CST) Antibodies for BACH2 (BACH2)
- Search for Antibodies & Assays
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for BACH2
- Novus Biologicals proteins and lysates for BACH2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for BACH2: See all 72
- Search antibodies-online for kits
- antibodies-online Proteins for BACH2: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for BACH2
- Search GeneTex for Proteins for BACH2
- ViGene Biosciences adenoviral particle packaged cDNA for BACH2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for BACH2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for BACH2 gene
- Search ViGene Biosciences for BACH2
- Horizon Cell Lines for BACH2
- Cyagen custom Knockout/knockin (KOKI) mouse models for BACH2
- VectorBuilder custom plasmid, inducible vectors for BACH2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BACH2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for BACH2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer