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Aliases & Descriptions for BACH2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| OTTHUMP00000016867 2 | | OTTHUMP00000016868 2 | | OTTHUMP00000040591 2 |
| | | Descriptions |
|---|
| BTB and CNC homolog 2 3 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 2 |
|
| | Search outside databases for aliases for BACH2 genePrevious GC identifers: GC06M090582 GC06M090631 |
Summaries for BACH2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9Function: Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity)Gene Wiki entry for BACH2 |
Genomic Location for BACH2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the BACH2 gene 
Entrez Gene cytogenetic band: 6q15 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q15BACH2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M090692:
(about GC identifiers)
Start:
|
90,692,969 bp from pter |
End:
|
91,063,182 bp from pter |
Size:
|
370,214 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007299.12
| Proteins for BACH2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9 (See
protein sequence)Recommended Name: Transcription regulator protein BACH2 Size: 841 amino acids; 92537 Da
Subunit: Heterodimer of BACH2 and Maf-related transcription factors (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q59H70 Q5T793 Q9NTS5Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_068585.1
ENSEMBL proteins: ENSP00000257749 ENSP00000345642 ENSP00000384145
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: BACH2 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for BACH2: Assays for BACH2: | Protein
Domains/ Families for BACH2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BYV9
ProtoNet protein and cluster: Q9BYV9 2 Blocks protein families: IPB000210 BTB/POZ domain IPB011616 bZIP transcription factor
UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9Similarity: Belongs to the bZIP family. CNC subfamilySimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 1 bZIP domain | Gene Function for BACH2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021813
Applied Biosystems Silencer® siRNAs for BACH2
Sigma-Aldrich siRNA and siRNA Panels for BACH2  Sigma-Aldrich shRNA for BACH2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021813                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021813                                  untagged cDNA clone in CMV expression vector: NM_021813 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_021813
UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9Function: Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity)2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Bach2):
3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- | | GO:0046983 | protein dimerization activity |
IEA | -- | About this table | Pathways & Interactions for BACH2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for BACH2 
5/15 Interacting proteins for BACH2 (ENSP000003456423) via UniProtKB, MINT, and/or STRING (see all 15
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | About this table
|
Drugs & Compounds for BACH2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for BACH2 4 Novoseek chemical compound relationships for BACH2 gene
About this table
|
Transcripts for BACH2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021813
Sigma-Aldrich siRNA and siRNA Panels for BACH2  Sigma-Aldrich shRNA for BACH2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_021813 REFSEQ mRNAs for BACH2 gene: NM_021813.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_021813               OriGene GFP tagged cDNA clone in CMV expression vector: NM_021813                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021813                                  untagged cDNA clone in CMV expression vector: NM_021813  Additional cDNA sequence: AB208889.1 AF357835.1 AJ271878.1 5 DOTS entries: DT.428799 DT.100749486 DT.91746418 DT.100701438 DT.100727669 24/91 AceView cDNA sequences (see all 91
):AA748480 H91131 AI187096 AI471915 AL512739 Z43962 Z40021 AA737041 AA721741 BQ421487 BQ187418 AA488974 AW505021 AL157663 R37011 AA767318 CF143478 AA832164 BC070239 CD522675 AA279412 AA749185 AF357835 BP366626
highest scoring ESTs for BACH2:AA740709 AA766300 AA831956 AA885077 AA972214 AI051668 AI373181 AI524722 AW014002 N63938 Unigene Clusters for BACH2: BTB and CNC homology 1, basic leucine zipper transcription factor 2 Hs.269764 [show with all ESTs], Hs.716609 [show with all ESTs]Unigene Representative Sequences: AL512739, NM_021813
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for BACH2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for BACH2
3 Ensembl transcripts including schematic representations: ENST00000257749
ENST00000343122
ENST00000406998
|
Expression for BACH2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| BACH2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for BACH2
1 / 2 / 3 9 probe-sets matching BACH2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCCTTTAGAA
SOURCE GeneReport for Unigene clusters: Hs.269764 Hs.716609 UniProtKB/Swiss-Prot: BACH2_HUMAN, Q9BYV9Tissue specificity: B-cell specific |
Orthologs for BACH2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BACH2 gene from 5/7 species (see all 7
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
BACH21 |
-- |
BTB and CNC homology 1, basic leucine zipper transcription more |
92.13(n) 94.04(a) |
481923 XM_539044.2 XP_539044.2 |
cow (Bos taurus) |
BACH21 |
-- |
BTB and CNC homology 1, basic leucine zipper transcription more |
90.92(n) 94.05(a) |
538296 XM_618496.3 XP_618496.2 |
rat (Rattus norvegicus) |
RGD15628651 |
-- |
similar to BTB and CNC homology 1, basic leucine zipper more |
87.59(n) 90.45(a) |
313125 XM_232858.4 XP_232858.3 |
mouse (Mus musculus) |
Bach25 |
4 |
BTB and CNC homology 2 |
-- |
D86604
|
chicken (Gallus gallus) |
BACH21 |
-- |
BTB and CNC homology 1, basic leucine zipper transcription more |
79.91(n) 81.41(a) |
421809 XM_419833.2 XP_419833.2 |
About this table Species with no ortholog for BACH2
ENSEMBL Gene Tree for BACH2 | Paralogs for BACH2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for BACH2 gene
- BACH12
|
SNPs/Variants for BACH2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for BACH2 (up to first 250kb)
|
Disorders & Mutations for BACH2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605394
4 Novoseek disease relationships for BACH2 gene
About this table
1 PharmGKB disease relationship for BACH2 geneAbout this table
Human Genome Epidemiology Navigator: BACH2 (3 documents)
|
Medical News for BACH2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for BACH2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/34 PubMed articles for BACH2 gene (see all 34
):- Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15. (PubMed id 10949928)1, 2, 3, 4 Sasaki S.... Yokoyama M. (2000)
- Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene. (PubMed id 11746976)1, 3, 4 Vieira S.A.D.... Melo J.V. (2001)
- B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs. (PubMed id 12829606)1, 2, 3 Kamio T....Ito E. (2003)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression. (PubMed id 17383980)1, 3 Hoshino H....Yoshida M. (2007)
- Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6. (PubMed id 18256039)1, 3 Ochiai K....Igarashi K. (2008)
- The role of Bach2 in nucleic acid-triggered antiviral innate immune responses. (PubMed id 17991429)1, 3 Hong S.W....Lee D.K. (2008)
- Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2. (PubMed id 15060166)1, 3 Tashiro S....Igarashi K. (2004)
- Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1. (PubMed id 17018862)1, 3 Yoshida C....Melo J.V. (2007)
- Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. (PubMed id 18840781)3 Grant S.F....Hakonarson H. (2009)
|
Search for BACH2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing BACH2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing BACH2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BACH2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for BACH2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for BACH2:

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Incremental update: 13 Oct 2009
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