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BACH1 Gene

protein-coding GIFtS: 62

GC21P029593

BTB and CNC homology 1, basic leucine zipper transcription factor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
BACH-1 ^¹, ²
HA2303 ^³
OTTHUMP00000096564 ^²

Descriptions
BTB and CNC homolog 1 ^³
BTB and CNC homology 1 transcription factor ^²
BTB and CNC homology 1, basic leucine zipper transcription factor 1 ^²
basic region leucine zipper transcriptional regulator BACH1 ^²
transcription regulator protein ⁹

External Ids
HGNC: 935¹
Entrez Gene: 571²
UniProtKB: O14867³
Ensembl: ENSG00000156273⁷

Search outside databases for aliases for BACH1 gene

Previous GC identifers: GC21P027248 GC21P029591

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BACH1:

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic

region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex,

tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip

family members. These BTB/POZ domains facilitate protein-protein interactions and formation of

homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it

functions as a repressor of Maf recognition element (MARE) and transcription is repressed.

Multiple alternatively spliced transcript variants have been identified for this gene. [provided

by RefSeq]

UniProtKB/Swiss-Prot: BACH1_HUMAN, O14867

Function: Transcriptional regulator that acts as repressor or activator. Binds, in-vitro, to NF-E2

binding sites. Play important roles in coordinating transcription activation and repression by

MAFK

Gene Wiki entry for BACH1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11 Ensembl cytogenetic band: 21q21.3 HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band: 21q22.11

BACH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21P029593:	GeneLoc	Nature:405,311-319
Start:	29,593,091 bp from pter	16,247,722 bp from centromere
End:	29,656,088 bp from pter	16,294,818 bp from centromere
Size:	62,998 bases	47,097 bases
Orientation:	plus strand	plus strand

RefSeq DNA sequence:

NC_000021.7 NT_011512.10

Whole chromosome sequencing:
cDNA sequence:	A20292
genomic clones:	P292A20

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BACH1_HUMAN, O14867 (See protein sequence)

Recommended Name: Transcription regulator protein BACH1

Size: 736 amino acids; 81958 Da

Subcellular location: Nucleus (By similarity)

PDB structures from and Proteopedia :

2IHC (3D)

Secondary accessions: O43285

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001011545.1 NP_001177.1 NP_996749.1

ENSEMBL proteins:

ENSP00000382805 ENSP00000286800 ENSP00000372296 ENSP00000382802

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BACH1.3)
	Human Recombinant Proteins from Abnova (BACH1)

OriGene Purified Recombinant Human Proteins (see all 2): BACH1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	colocalizes with nucleus	IDA	16780588
GO:0005730	NOT nucleolus	IDA	18029348
GO:0005829	colocalizes with cytosol	IDA	16780588

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Antibodies for BACH1:

	Invitrogen Antibodies for BACH1
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for BACH1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (BACH1.3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BACH1)
	Novus Biologicals Antibodies for BACH1

Assays for BACH1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O14867

ProtoNet protein and cluster: O14867

2 Blocks protein families:

IPB000210 BTB/POZ domain

IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: BACH1_HUMAN, O14867

Similarity: Belongs to the bZIP family. CNC subfamily

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 1 bZIP domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BACH1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BACH1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001186

Applied Biosystems Silencer® siRNAs for BACH1

Sigma-Aldrich siRNA and siRNA Panels for BACH1

Sigma-Aldrich shRNA for BACH1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001011545
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001011545
untagged cDNA clones in CMV expression vector (see all 3): NM_001011545

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_206866

UniProtKB/Swiss-Prot: BACH1_HUMAN, O14867

Function: Transcriptional regulator that acts as repressor or activator. Binds, in-vitro, to NF-E2

binding sites. Play important roles in coordinating transcription activation and repression by

MAFK

Genatlas biochemistry entry for BACH1:

murine Bac-1 transcription factor homolog,ubiquitously expressed,interacting with

MAFK,transcription repressor in fibroblasts,activator in cultured erythroid cells

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Bach1):

homeostasis/metabolism

muscle

normal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	9479503 9544839
GO:0043565	sequence-specific DNA binding	IEA	--
GO:0046983	protein dimerization activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for BACH1 (Your Favorite Gene powered by Ingenuity)

NRF2-mediated Oxidative Stress Response
Role of BRCA1 in DNA Damage Response

GeneDecks BACH1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BACH1

3 Interacting proteins for BACH1 (ENSP00000286800³ O14867¹) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BRCA1	P38398¹	STRING (score=.913) EBI-1263541, EBI-349905
BACH2	ENSP00000345642³	STRING (score=.803)
MAFK	ENSP00000344903³	STRING (score=.755)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BACH1
5 Novoseek chemical compound relationships for BACH1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	51.97	5	10620011 (2), 9565602 (1), 12511571 (1), 9479503 (1)
iron	47.80	2	17901053 (1), 12511571 (1)
deferoxamine	36.42	1	12511571 (1)
oxygen	21.04	2	17901053 (1), 12511571 (1)
cadmium	18.09	7	14504288 (4), 15345152 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BACH1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BACH1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001186

Sigma-Aldrich siRNA and siRNA Panels for BACH1

Sigma-Aldrich shRNA for BACH1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001011545 NM_001186 NM_206866

REFSEQ mRNAs for BACH1 gene (3 alternative transcripts):

NM_001011545.1 NM_001186.2 NM_206866.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001011545 NM_001186 NM_206866

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001011545
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001011545
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001011545

Additional cDNA sequence:

AB002803.1 AF026199.1 AF026200.1 AF317902.1 AF490769.1 AK291021.1 AK313791.1 BC063307.1

BC065252.1 CR450303.1

10 DOTS entries:

DT.451634 DT.95266471 DT.97815312 DT.97778939 DT.99997001 DT.100655891 DT.121130529 DT.91758720

DT.92034558 DT.95266469

2 AceView cDNA sequences:

AF317902 BF372373

highest scoring ESTs for BACH1:

AB002803 AF317902 AA215456 AA233996 AA252603 AA382183 AA382184 AA399950 AA402241 AA412052

Unigene Cluster for BACH1:

BTB and CNC homology 1, basic leucine zipper transcription factor 1

Hs.154276 [show with all ESTs]

Unigene Representative Sequence: NM_206866

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for BACH1

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8a	·	8b
SP1:							-		-		-		-
SP2:									-		-		-
SP3:							-		-				-
SP4:							-		-
SP5:											-		-

About this scheme

ECgene alternative splicing isoforms for BACH1

4 Ensembl transcripts including schematic representations:

ENST00000399921 ENST00000286800 ENST00000382845 ENST00000399919

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BACH1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BACH1

¹ / ² / ³

7 probe-sets matching BACH1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31895_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AB002803	0.80	1.00	0.91	1
210818_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF026199	0.60	1.00	0.82	1
234315_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF317902	0.80	1.00	0.91	1
204194_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001186	0.60	1.00	0.82	1
210818_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
234315_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204194_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks BACH1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.154276
Expression variation in blood from EXPOLDB for BACH1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BACH1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BACH1¹	--	BTB and CNC homology 1, basic leucine zipper transcription more	88.41(n) 87.64(a)	487718 XM_544842.1 XP_544842.1
chimpanzee (Pan troglodytes)	BACH1¹	--	BTB and CNC homology 1, basic leucine zipper transcription more	99.64(n) 99.73(a)	745234 XM_001161764.1 XP_001161764.1
cow (Bos taurus)	BACH1¹	--	BTB and CNC homology 1, basic leucine zipper transcription more	81.53(n) 83.13(a)	531350 XM_609842.3 XP_609842.2
rat (Rattus norvegicus)	Bach1¹	--	BTB and CNC homology 1, basic leucine zipper transcription more	79.73(n) 80(a)	304127 XM_221712.4 XP_221712.2
mouse (Mus musculus)	Bach1^{1, 5}	16⁵	BTB and CNC homology 1^{1, 5}	79.77(n)¹ 80.82(a)¹	12013¹ NM_007520.2¹ NP_031546.1¹ AI323795⁵ AK030871⁵ (see all 13)

About this table Species with no ortholog for BACH1

ENSEMBL Gene Tree for BACH1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BACH1 gene

BACH2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/362 NCBI SNPs in BACH1 are shown (see all 362 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 101)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs368322^1,2	A,C,F,H,O	29639022(+)	`TACACT/CCAACT`	3	--	ut3¹ int¹ ese³		12	NA EU EA WA	938
	rs2832291^1,2	A,C,F,H,O	29656259(+)	`ACTTAC/TTTAAA`	1	--	ng3¹		11	NA EU EA	819
	rs15092^1,2	A,C,F,H	29640072(+)	`TGGTAA/GAAGAT`	3	--	ut3¹ int¹		16	MN EA NA EU WA	1251
	rs372883^1,2	C,F,H,O	29639608(-)	`AGTGAG/ACAATG`	3	--	ut3¹ int¹ ese³		13	MN EU EA WA NA	1181
--	rs425989^1,2	C,F,H	29637146(+)	`TACCAT/CAAGGG`	3	--	int¹ ut3¹ ese³		10	MN EA NA EU WA	2245
	rs2070401^1,2	C,F,H	29637356(-)	`TTAAAT/CTGCTG`	3	--	ut3¹ int¹		8	EA NA EU WA	2040
	rs2300301^1,2	C,F,H	29598187(+)	`GTTACA/GTTAAT`	3	--	int¹ ng5¹		8	EA NA EU WA	2034
	rs2832285^1,2	F,O	29637151(+)	`CAAGGG/CAATTT`	3	--	ut3¹ int¹		1	NA	10
	rs8133805^1,2	F,H	29638182(+)	`TGGTAT/CAAAGA`	3	--	ut3¹ int¹		4	EU EA WA	420
	rs35474725^1,2	C,F	29620956(-)	`TATGGA/GAGAAT`	3	S/P	mis¹		5	NA EU EA WA	494

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HapMap Linkage Disequilibrium images for BACH1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602751

2 Novoseek disease relationships for BACH1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
monosomy	43.55	1	9544839 (1)
erythroleukemia	42.91	2	14660636 (1), 15464985 (1)

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1 PharmGKB disease relationship for BACH1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12730115

About this table

Genetic Association Database: BACH1
Human Genome Epidemiology Navigator: BACH1 (19 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/61 PubMed articles for BACH1 gene (see all 61 ):

Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1. (PubMed id 9479503)^{1, 2, 3, 4} Ohira M....Ohara O. (1998)
Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1. (PubMed id 9544839)^{1, 2, 3, 4} Blouin J.-L.... Antonarakis S.E. (1998)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{3, 4} Hattori M....Yaspo M.L. (2000)
Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants. (PubMed id 15734732)^{1, 3} Dhakshinamoorthy S....Jaiswal A.K. (2005)
Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene. (PubMed id 14504288)^{1, 3} Suzuki H....Igarashi K. (2003)
BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite. (PubMed id 18550526)^{1, 3} Reichard J.F....Puga A. (2008)
Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells. (PubMed id 15464985)^{1, 3} Tahara T....Taketani S. (2004)
Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1. (PubMed id 15175654)^{1, 3} Suzuki H....Igarashi K. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 571	HGNC: 935	AceView: BACH1.1	Ensembl:ENSG00000156273	euGenes: HUgn571
ECgene: BACH1	H-InvDB: BACH1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for BACH1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BACH1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BACH1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BACH1		Antibodies for BACH1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BACH1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BACH1)
	Antibodies (BACH1)
	Chimera RNAi (BACH1)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (BACH1.3)
	Antibodies (BACH1.3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for BACH1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BACH1

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BACH1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for BACH1

Summaries
for BACH1

Genomic Location
for BACH1

Proteins
for BACH1

Protein Domains/
Families
for BACH1

Gene Function
for BACH1

Pathways & Interactions
for BACH1

Drugs & Compounds
for BACH1

Transcripts
for BACH1

Expression
for BACH1

Orthologs
for BACH1

Paralogs
for BACH1

SNPs/Variants
for BACH1

Disorders & Mutations
for BACH1

Medical News
for BACH1

Publications
for BACH1

Search for BACH1

Genome Databases showing BACH1

Other Databases showing BACH1

Specialized Databases showing BACH1

Licensable Technologies
for BACH1

Services
for BACH1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BACH1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor BACH1

Summariesfor BACH1

Genomic Locationfor BACH1

Proteinsfor BACH1

Protein Domains/Familiesfor BACH1

Gene Functionfor BACH1

Pathways & Interactionsfor BACH1

Drugs & Compoundsfor BACH1

Transcriptsfor BACH1

Expression for BACH1

Orthologsfor BACH1

Paralogsfor BACH1

SNPs/Variantsfor BACH1

Disorders & Mutationsfor BACH1

Medical Newsfor BACH1

Publicationsfor BACH1

Search for BACH1

Genome Databases showing BACH1

Other Databases showing BACH1

Specialized Databases showing BACH1

Licensable Technologiesfor BACH1

Servicesfor BACH1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BACH1

Summaries
for BACH1

Genomic Location
for BACH1

Proteins
for BACH1

Protein Domains/
Families
for BACH1

Gene Function
for BACH1

Pathways & Interactions
for BACH1

Drugs & Compounds
for BACH1

Transcripts
for BACH1

Expression
for BACH1

Orthologs
for BACH1

Paralogs
for BACH1

SNPs/Variants
for BACH1

Disorders & Mutations
for BACH1

Medical News
for BACH1

Publications
for BACH1

Licensable Technologies
for BACH1

Services
for BACH1