BACH1 Gene

Aliases
for BACH1 gene

Previous GC identifers: GC21P027248 GC21P029591 GC21P029593 GC21P030671 GC21P016079

Summaries
for BACH1 gene

Genomic Views
for BACH1 gene

Proteins
for BACH1 gene

1 PDB 3D structure from and Proteopedia for BACH1:

2IHC (3D)    

Explore the universe of human proteins at neXtProt for BACH1: NX_O14867

Post-translational modifications:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): BACH1 OriGene Protein Over-expression Lysate (see all 2): BACH1 OriGene Custom Protein Services for BACH1
	GenScript Custom Purified and Recombinant Proteins Services for BACH1
	Novus Biologicals BACH1 Protein Novus Biologicals BACH1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for BACH1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

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	R&D Systems Antibodies for BACH1
	OriGene Antibodies (see all 2): BACH1 OriGene Custom Antibody Services for BACH1
	GenScript Custom Superior Antibodies Services for BACH1
	Novus Biologicals BACH1 Antibodies
	Abcam antibodies for BACH1
	Uscn Antibodies for BACH1
	ThermoFisher Antibodies for BACH1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for BACH1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for BACH1

Protein Domains /
Families
for BACH1 gene

ProtoNet protein and cluster: O14867

Function
for BACH1 gene

miRNA Products:		miRTarBase miRNAs that target BACH1: kshv-mir-k12-11 (MIRT003981), hsa-mir-155 (MIRT001043), hsa-mir-196a (MIRT004718)
		OriGene 3'-UTR Clone (see all 2): BACH1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BACH1
		8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate BACH1 (see all 86):
		hsa-miR-140-5p hsa-miR-576-3p hsa-miR-579 hsa-miR-607 hsa-miR-30d hsa-miR-30a hsa-miR-3622b-3p hsa-miR-3613-3p
		SwitchGear 3'UTR luciferase reporter plasmids (see all 2): BACH1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BACH1 (see all 7) OriGene shRNA RFP: BACH1 OriGene siRNA: BACH1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BACH1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for BACH1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BACH1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BACH1 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): BACH1 (NM_001186)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BACH1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BACH1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BACH1
		Search LifeMap BioReagents cell lines for BACH1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BACH1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

(inferred from 1 allele) (MGI details for Bach1)

Pathways & Interactions
for BACH1 gene

	Super-pathway	contained gene-specific pathways
1	Integrated Breast Cancer Pathway	Integrated Breast Cancer Pathway 1.00
2	BRCA1 Pathway	BRCA1 Pathway 1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for BACH1

BRCA1 Pathway

1 BioSystems Pathway for BACH1

Integrated Breast Cancer Pathway

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for BACH1 gene

Transcripts
for BACH1 gene

Expression
for BACH1 gene

BACH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	PureStem™ progenitor T36 (Embryonic Progenitor Cell)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BACH1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BACH1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BACH1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BACH1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BACH1

Orthologs
for BACH1 gene

Paralogs
for BACH1 gene

Paralogs for BACH1 gene

NFE2L1²  BACH2²  NFE2L3²  NFE2²  NFE2L2²  

18/19 SIMAP similar genes for BACH1 using alignment to 9 protein entries:     BACH1_HUMAN (see all proteins) (see all similar genes):

ZBTB7C    KLHL2    ZNF295    ZNF131    BACH2    ZBTB16

BCL6    BCL6B    HIC1    ZBTB49    KLHL32    ZBTB22

ZBTB10    ZBTB25    ZBTB44    MYNN    ZBTB1    ZBTB14

BACH1 for paralogs           About GeneDecksing

Genomic Variants
for BACH1 gene

10/1110 NCBI SNPs in BACH1 are shown (see all 1110)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1126335361,2		--	16077820(+)	GGAGGG/ATCTGA	1	--	us2k1		1		CSA	2
rs738977451,2	C,	--	16077869(+)	TGCATC/AGGTGT	1	--	us2k1		1		WA	2
rs738977461,2	C,	--	16078065(+)	CCTACC/ATCTGG	2	--	us2k1		2		WA	120
rs75098671,2	C,H,	--	16079376(+)	GCTCTC/TGCTTC	2	--	ut51 us2k1 ese3		2		NS NA	180
rs75099721,2	C,	--	16079380(+)	TCGCTG/TCAGTC	2	--	us2k1 ut51 ese3		0	--	--	--	--
rs1123690441,2	C,	--	16080676(+)	TGATTC/GTTGTA	2	--	int1		0	--	--	--	--
rs738977471,2	C,F,	--	16081363(+)	AATAGG/CCAACC	2	--	int1		2		WA CSA	4
rs738977481,2	C,F,	--	16081923(+)	TCAGAC/TTGTTA	2	--	int1		2		WA CSA	4
rs39268701,2	A	--	16082045(-)	TCTGTA/TTTTTT	2	--	int1		0	--	--	--	--
rs791041661,2	C,F,	--	16082141(+)	AAAAGG/AGTGCA	2	--	int1		1		WA	118

HapMap Linkage Disequilibrium report for BACH1 (30566392 - 30816392 bp, first 250kb of BACH1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BACH1
     1 CNV: 90746

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BACH1

DNA2.0 Custom Variant and Variant Library Synthesis for BACH1

Disorders / Diseases
for BACH1 gene

18 diseases for BACH1

2 Novoseek disease relationships for BACH1 gene    About this table

Publications
for BACH1 gene

PubMed articles for BACH1 gene, integrated from 9 sources (see all 88): (articles sorted by number of sources associating them with BACH1)

Utopia: connect your pdf to the dynamic world of online information

1. Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1. (PubMed id 9479503)^{1, 2, 3, 9} Ohira M....Ohara O. (1998)
2. Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1. (PubMed id 9544839)^{1, 2, 3, 9} Blouin J.-L.... Antonarakis S.E. (1998)
3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. The DNA sequence of human chromosome 21. (PubMed id 10830953)^{1, 2} Hattori M....Yaspo M.L. (2000)
6. Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants. (PubMed id 15734732)^{1, 9} Dhakshinamoorthy S....Jaiswal A.K. (2005)
7. Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene. (PubMed id 14504288)^{1, 9} Suzuki H....Igarashi K. (2003)
8. BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite. (PubMed id 18550526)^{1, 9} Reichard J.F....Puga A. (2008)
9. Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells. (PubMed id 15464985)^{1, 9} Tahara T....Taketani S. (2004)
10. Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1. (PubMed id 15175654)^{1, 9} Suzuki H....Igarashi K. (2004)

External Searches for BACH1 gene

Genome Databases showing BACH1 gene

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Products
for BACH1 gene