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Aliases for BACH1 Gene

Aliases for BACH1 Gene

  • BTB And CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 2 3
  • Basic Region Leucine Zipper Transcriptional Regulator BACH1 3
  • Transcription Regulator Protein BACH1 3
  • BTB And CNC Homolog 1 4
  • HA2303 4
  • BACH-1 3
  • BTBD24 3

External Ids for BACH1 Gene

Previous GeneCards Identifiers for BACH1 Gene

  • GC21P027248
  • GC21P029591
  • GC21P029593
  • GC21P030671
  • GC21P016079
  • GC21P030567
  • GC21P030570

Summaries for BACH1 Gene

Entrez Gene Summary for BACH1 Gene

  • This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for BACH1 Gene

BACH1 (BTB And CNC Homology 1, Basic Leucine Zipper Transcription Factor 1) is a Protein Coding gene. Diseases associated with BACH1 include fanconi anemia, complementation group j and breast cancer. Among its related pathways are BRCA1 Pathway and Integrated Breast Cancer Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and heme binding. An important paralog of this gene is NFE2.

UniProtKB/Swiss-Prot for BACH1 Gene

  • Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK

Gene Wiki entry for BACH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BACH1 Gene

Genomics for BACH1 Gene

Regulatory Elements for BACH1 Gene

Transcription factor binding sites by QIAGEN in the BACH1 gene promoter:

Genomic Location for BACH1 Gene

Start:
29,194,071 bp from pter
End:
29,630,751 bp from pter
Size:
436,681 bases
Orientation:
Plus strand

Genomic View for BACH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BACH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BACH1 Gene

Proteins for BACH1 Gene

  • Protein details for BACH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14867-BACH1_HUMAN
    Recommended name:
    Transcription regulator protein BACH1
    Protein Accession:
    O14867
    Secondary Accessions:
    • O43285
    • Q6ICU0

    Protein attributes for BACH1 Gene

    Size:
    736 amino acids
    Molecular mass:
    81958 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for BACH1 Gene

neXtProt entry for BACH1 Gene

Proteomics data for BACH1 Gene at MOPED

Post-translational modifications for BACH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for BACH1 Gene

Domains for BACH1 Gene

Gene Families for BACH1 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • bZIP :basic leucine zipper proteins

Graphical View of Domain Structure for InterPro Entry

O14867

UniProtKB/Swiss-Prot:

BACH1_HUMAN :
  • O14867
Domain:
  • Contains 1 BTB (POZ) domain.
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. CNC subfamily.
genes like me logo Genes that share domains with BACH1: view

Function for BACH1 Gene

Molecular function for BACH1 Gene

GENATLAS Biochemistry:
murine Bac-1 transcription factor homolog,ubiquitously expressed,interacting with MAFK,transcription repressor in fibroblasts,activator in cultured erythroid cells
UniProtKB/Swiss-Prot Function:
Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK

Gene Ontology (GO) - Molecular Function for BACH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IMP 21555518
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0001206 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0003677 DNA binding --
genes like me logo Genes that share ontologies with BACH1: view
genes like me logo Genes that share phenotypes with BACH1: view

Animal Models for BACH1 Gene

MGI Knock Outs for BACH1:

Animal Model Products

Targeting motifs for BACH1 Gene
HOMER Transcription Factor Regulatory Elements motif BACH1
  • Consensus sequence: AWWNTGCTGAGTCAT Submotif: canonical Cell Type: K562 GeoId: GSE31477

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BACH1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for BACH1 Gene

Localization for BACH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BACH1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BACH1 Gene COMPARTMENTS Subcellular localization image for BACH1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for BACH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 colocalizes_with nucleus IDA 16780588
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 colocalizes_with cytosol IDA 16780588
genes like me logo Genes that share ontologies with BACH1: view

Pathways for BACH1 Gene

genes like me logo Genes that share pathways with BACH1: view

Pathways by source for BACH1 Gene

1 Qiagen pathway for BACH1 Gene
1 BioSystems pathway for BACH1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BACH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IMP 21555518
GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle IMP 21555518
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 21555518
GO:0006281 DNA repair IMP 11301010
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with BACH1: view

Compounds for BACH1 Gene

(7) Novoseek inferred chemical compound relationships for BACH1 Gene

Compound -log(P) Hits PubMed IDs
succinylacetone 70 6
leucine 54.8 7
iron 45.9 3
deferoxamine 43.9 1
oxygen 23 2
genes like me logo Genes that share compounds with BACH1: view

Transcripts for BACH1 Gene

mRNA/cDNA for BACH1 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BACH1 Gene

BTB and CNC homology 1, basic leucine zipper transcription factor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BACH1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BACH1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -

Relevant External Links for BACH1 Gene

GeneLoc Exon Structure for
BACH1
ECgene alternative splicing isoforms for
BACH1

Expression for BACH1 Gene

mRNA expression in normal human tissues for BACH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BACH1 Gene

This gene is overexpressed in Whole Blood (5.1).

Protein differential expression in normal tissues for BACH1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.7), Monocytes (12.4), and Testis (11.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BACH1 Gene

SOURCE GeneReport for Unigene cluster for BACH1 Gene Hs.154276

genes like me logo Genes that share expressions with BACH1: view

Expression partners for BACH1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for BACH1 Gene

Orthologs for BACH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BACH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BACH1 35
  • 81.53 (n)
  • 83.13 (a)
BACH1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BACH1 35
  • 88.41 (n)
  • 87.64 (a)
BACH1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bach1 35
  • 79.68 (n)
  • 80.82 (a)
Bach1 16
Bach1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BACH1 35
  • 99.64 (n)
  • 99.73 (a)
BACH1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bach1 35
  • 79.64 (n)
  • 80 (a)
oppossum
(Monodelphis domestica)
Mammalia BACH1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BACH1 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves BACH1 35
  • 69.35 (n)
  • 65.89 (a)
BACH1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BACH1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bach1 35
  • 58.61 (n)
  • 52.5 (a)
Str.14783 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16158 35
zebrafish
(Danio rerio)
Actinopterygii bach1 36
  • 46 (a)
OneToMany
BACH1 (2 of 2) 36
  • 30 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cnc 36
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for BACH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BACH1 Gene

ENSEMBL:
Gene Tree for BACH1 (if available)
TreeFam:
Gene Tree for BACH1 (if available)

Paralogs for BACH1 Gene

Paralogs for BACH1 Gene

genes like me logo Genes that share paralogs with BACH1: view

Variants for BACH1 Gene

Sequence variations from dbSNP and Humsavar for BACH1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs11532 -- 29,345,608(+) TTTTT(A/T)ACAGT utr-variant-3-prime, intron-variant
rs15092 -- 29,345,880(+) TGGTA(A/G)AAGAT utr-variant-3-prime, intron-variant
rs117213 -- 29,348,215(+) CTGGA(A/G)TTGTC intron-variant
rs117214 -- 29,348,513(+) GTGTT(C/T)TGTAA intron-variant
rs368322 -- 29,344,830(+) TACAC(C/T)CAACT utr-variant-3-prime, intron-variant

Relevant External Links for BACH1 Gene

HapMap Linkage Disequilibrium report
BACH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BACH1 Gene

Disorders for BACH1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BACH1 Gene in MalaCards »

(2) Diseases for BACH1 Gene including...

(2) Novoseek inferred disease relationships for BACH1 Gene

Disease -log(P) Hits PubMed IDs
monosomy 39.6 1
erythroleukemia 39.4 2

Relevant External Links for BACH1

Genetic Association Database (GAD)
BACH1
Human Genome Epidemiology (HuGE) Navigator
BACH1
genes like me logo Genes that share disorders with BACH1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for BACH1 Gene

Publications for BACH1 Gene

  1. Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1. (PMID: 9479503) Ohira M. … Ohara O. (Genomics 1998) 2 3 4 23
  2. Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1. (PMID: 9544839) Blouin J.-L. … Antonarakis S.E. (Hum. Genet. 1998) 2 3 4 23
  3. Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells. (PMID: 12511571) Kitamuro T. … Shibahara S. (J. Biol. Chem. 2003) 3 23
  4. Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene. (PMID: 14504288) Suzuki H. … Igarashi K. (J. Biol. Chem. 2003) 3 23
  5. Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells. (PMID: 14660636) Tahara T. … Taketani S. (J. Biol. Chem. 2004) 3 23

Products for BACH1 Gene

Sources for BACH1 Gene

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