Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BACH1 Gene

protein-coding   GIFtS: 59
GCID: GC21P030570

BTB And CNC Homology 1, Basic Leucine Zipper Transcription...

  See BACH1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

TryGeneCards Plus

Aliases
BTB And CNC Homology 1, Basic Leucine Zipper Transcription Factor 11 2     BACH-12
HA23032 3     Basic Region Leucine Zipper Transcriptional Regulator BACH12
BTB And CNC Homolog 12 3     Transcription Regulator Protein BACH12
Transcription Regulator Protein11     

External Ids:    HGNC: 9351   Entrez Gene: 5712   Ensembl: ENSG000001562737   OMIM: 6027515   UniProtKB: O148673   

Export aliases for BACH1 gene to outside databases

Previous GC identifers: GC21P027248 GC21P029591 GC21P029593 GC21P030671 GC21P016079 GC21P030567


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for BACH1 Gene:
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper
factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc
finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate
protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a
heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is
repressed. Multiple alternatively spliced transcript variants have been identified for this gene. (provided by
RefSeq, May 2009)

GeneCards Summary for BACH1 Gene:
BACH1 (BTB and CNC homology 1, basic leucine zipper transcription factor 1) is a protein-coding gene. Diseases associated with BACH1 include breast cancer, early-onset, and fanconi anemia, complementation group j. GO annotations related to this gene include heme binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is BACH2.

UniProtKB/Swiss-Prot: BACH1_HUMAN, O14867
Function: Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites.
Play important roles in coordinating transcription activation and repression by MAFK

Gene Wiki entry for BACH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BACH1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBACH1 promoter sequence

   Search Chromatin IP Primers for BACH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BACH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q22.1
Nature(405: 311-319) cytogenetic band:   21q22.11
BACH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BACH1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P030570:   GeneLoc Nature:405,311-319
Start:
30,566,392 bp from pter       16,247,722 bp from centromere
End:
31,003,071 bp from pter 16,294,818 bp from centromere
Size:
436,680 bases 47,097 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: A20292
genomic clones: P292A20


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BACH1_HUMAN, O14867 (See protein sequence)
Recommended Name: Transcription regulator protein BACH1  
Size: 736 amino acids; 81958 Da
1 PDB 3D structure from and Proteopedia for BACH1:
2IHC (3D)    
Secondary accessions: O43285

Explore the universe of human proteins at neXtProt for BACH1: NX_O14867

Explore proteomics data for BACH1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BACH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177.1  NP_996749.1  

    ENSEMBL proteins: 
     ENSP00000447332   ENSP00000449316   ENSP00000448663   ENSP00000449383   ENSP00000286800  
     ENSP00000382805   ENSP00000448982   ENSP00000400576   ENSP00000408605   ENSP00000392202  
     ENSP00000416569   ENSP00000470673  

    BACH1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for BACH1
    OriGene Protein Over-expression Lysate for BACH1
    OriGene MassSpec for BACH1
    OriGene Custom Protein Services for BACH1
    GenScript Custom Purified and Recombinant Proteins Services for BACH1
    Novus Biologicals BACH1 Protein
    Novus Biologicals BACH1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BACH1

     
    Search eBioscience for Proteins for BACH1 

    BACH1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for BACH1
    OriGene Antibodies for BACH1
    OriGene Custom Antibody Services for BACH1
    Novus Biologicals BACH1 Antibodies
    Abcam antibodies for BACH1
    Cloud-Clone Corp. Antibodies for BACH1
    ThermoFisher Antibodies for BACH1
    LSBio Antibodies in human, mouse, rat for BACH1

    BACH1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BACH1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BACH1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BACH1
    Cloud-Clone Corp. CLIAs for BACH1
    Search eBioscience for ELISAs for BACH1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    bZIP: basic leucine zipper proteins

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR004827 bZIP
     IPR011333 BTB/POZ_fold
     IPR008917 TF_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry O14867

    ProtoNet protein and cluster: O14867

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: BACH1_HUMAN, O14867
    Similarity: Belongs to the bZIP family. CNC subfamily
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with BACH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BACH1_HUMAN, O14867
    Function: Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites.
    Play important roles in coordinating transcription activation and repression by MAFK

         Genatlas biochemistry entry for BACH1:
    murine Bac-1 transcription factor homolog,ubiquitously expressed,interacting with MAFK,transcription repressor in
    fibroblasts,activator in cultured erythroid cells

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IMP--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ISS--
    GO:0005515protein binding ----
    GO:0020037heme binding NAS--
         
    Find genes that share ontologies with BACH1           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bach1):
     cardiovascular system  cellular  homeostasis/metabolism  muscle  normal 

    Find genes that share phenotypes with BACH1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bach1tm1Igar for BACH1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BACH1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BACH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BACH1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BACH1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  AWWNTGCTGAGTCAT 

    miRNA
    Products:
        
    miRTarBase miRNAs that target BACH1:
    hsa-mir-769-5p (MIRT039211), hsa-mir-125b-5p (MIRT045958), hsa-mir-20a-5p (MIRT050569), kshv-mir-k12-11-3p (MIRT003981), hsa-mir-155-5p (MIRT001043), hsa-mir-196a-5p (MIRT004718)

    Block miRNA regulation of human, mouse, rat BACH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BACH1 (see all 86):
    hsa-miR-140-5p hsa-miR-576-3p hsa-miR-579 hsa-miR-607 hsa-miR-30d hsa-miR-30a hsa-miR-3622b-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): BACH1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BACH1
    Predesigned siRNA for gene silencing in human, mouse, rat BACH1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BACH1

    Clone
    Products:
         
    OriGene clones in human, mouse for BACH1 (see all 13)
    OriGene ORF clones in mouse, rat for BACH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BACH1 (NM_001186)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BACH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BACH1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BACH1
    Browse ESI BIO Cell Lines and PureStem Progenitors for BACH1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BACH1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    BACH1_HUMAN, O14867: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634colocalizes with nucleus IDA16780588
    GO:0005829colocalizes with cytosol IDA16780588

    Find genes that share ontologies with BACH1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for BACH1 About    
    See pathways by source

    SuperPathContained pathways About
    1Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway
    2BRCA1 Pathway
    BRCA1 Pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for BACH1
        BRCA1 Pathway

    1 BioSystems Pathway for BACH1
        Integrated Breast Cancer Pathway


        Pathway & Disease-focused RT2 Profiler PCR Array including BACH1: 
              TGFB Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BACH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BACH1 (O148673 ENSP000002868004) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAFGO155253, ENSP000003503694I2D: score=3 STRING: ENSP00000350369
    RBCK1Q9BYM83, ENSP000003486324I2D: score=2 STRING: ENSP00000348632
    BRCA1P383983, ENSP000003502834I2D: score=1 STRING: ENSP00000350283
    BRCA2P515873, ENSP000003694974I2D: score=1 STRING: ENSP00000369497
    MLH1P406923, ENSP000002317904I2D: score=1 STRING: ENSP00000231790
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle IMP--
    GO:0000117regulation of transcription involved in G2/M transition of mitotic cell cycle IMP--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0006355regulation of transcription, DNA-templated ISS--
    GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia IDA12511571

    Find genes that share ontologies with BACH1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BACH1

    7 Novoseek inferred chemical compound relationships for BACH1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    succinylacetone 70 9 14660636 (3), 15464985 (3)
    leucine 54.8 7 10620011 (2), 9565602 (1), 19822148 (1), 20127796 (1) (see all 6)
    iron 45.9 3 19777608 (1), 17901053 (1), 12511571 (1)
    deferoxamine 43.9 1 12511571 (1)
    oxygen 23 2 17901053 (1), 12511571 (1)
    cysteine 20.4 3 17701549 (2), 15855052 (1)
    cadmium 13.2 7 14504288 (4), 15345152 (1)



    Find genes that share compounds with BACH1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BACH1 gene (3 alternative transcripts): 
    NM_001186.2  NM_206866.1  NM_001011545.1  

    Unigene Cluster for BACH1:

    BTB and CNC homology 1, basic leucine zipper transcription factor 1
    Hs.154276  [show with all ESTs]
    Unigene Representative Sequence: NM_206866
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548219 ENST00000550131 ENST00000547141 ENST00000546469 ENST00000286800(uc002ynj.3 uc002ynl.2)
    ENST00000399921(uc002ynk.3) ENST00000548467 ENST00000451655 ENST00000447177
    ENST00000435072 ENST00000422809 ENST00000468059 ENST00000462262
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BACH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BACH1 (see all 86):
    hsa-miR-140-5p hsa-miR-576-3p hsa-miR-579 hsa-miR-607 hsa-miR-30d hsa-miR-30a hsa-miR-3622b-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): BACH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BACH1
    Predesigned siRNA for gene silencing in human, mouse, rat BACH1
    Clone
    Products:
         
    OriGene clones in human, mouse for BACH1 (see all 13)
    OriGene ORF clones in mouse, rat for BACH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BACH1 (NM_001186)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BACH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BACH1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BACH1
    OriGene qSTAR qPCR primer pairs in human, mouse for BACH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BACH1
      QuantiTect SYBR Green Assays in human, mouse, rat BACH1
      QuantiFast Probe-based Assays in human, mouse, rat BACH1

    Additional mRNA sequence: 

    AB002803.1 AF026199.1 AF026200.1 AF317902.1 AK291021.1 AK313791.1 BC063307.1 CR450303.1 
    NR_027655.1 

    8 DOTS entries:

    DT.451634  DT.95266471  DT.97778939  DT.100655891  DT.121130529  DT.91758720  DT.92034558  DT.95266469 

    2 AceView cDNA sequences:

    AF317902 BF372373 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BACH1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b
    SP1:                    -     -     -     -                                                   
    SP2:                          -     -     -                                                   
    SP3:                    -     -           -                                                   
    SP4:                    -     -                                                               
    SP5:                                -     -                                                   


    ECgene alternative splicing isoforms for BACH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BACH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BACH1 Expression
    About this image


    BACH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Kidney (Urinary System)
             Metanephros
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
    BACH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BACH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.154276
        Pathway & Disease-focused RT2 Profiler PCR Array including BACH1: 
              TGFB Signaling Targets in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BACH1
    OriGene qSTAR qPCR primer pairs in human, mouse for BACH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BACH1
    QuantiTect SYBR Green Assays in human, mouse, rat BACH1
    QuantiFast Probe-based Assays in human, mouse, rat BACH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BACH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for BACH1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bach11 , 5 BTB and CNC homology 11, 5 79.68(n)1
    80.82(a)1
      16 (49.84 cM)5
    120131  NM_007520.21  NP_031546.11 
     876989455 
    chicken
    (Gallus gallus)
    Aves BACH11 BTB and CNC homology 1, basic leucine zipper transcription more 69.35(n)
    65.89(a)
      418488  XM_004938377.1  XP_004938434.1 
    lizard
    (Anolis carolinensis)
    Reptilia BACH16
    BTB and CNC homology 1, basic leucine zipper trans...
    57(a)
    1 ↔ 1
    3(146438563-146465274)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.161582 Xenopus laevis transcribed sequence with weak similarity more 73.49(n)    BJ096331.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bach16
    BACH1 (2 of 2)6
    BTB and CNC homology 1, basic leucine zipper trans...
    BTB and CNC homology 1, basic leucine zipper trans...
    46(a)
    30(a)
    1 ↔ many
    1 ↔ many
    10(26004029-26016671) ENSDARG00000002196
    15(8242780-8266414) ENSDARG00000062553
    fruit fly
    (Drosophila melanogaster)
    Insecta cnc6
    cap-n-collar
    8(a)
    1 → many
    3R(19011302-19052430)


    ENSEMBL Gene Tree for BACH1 (if available)
    TreeFam Gene Tree for BACH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for BACH1 gene
    BACH22  NFE2L32  NFE2L12  NFE22  NFE2L22  
    Selected SIMAP similar genes for BACH1 using alignment to 9 protein entries:     BACH1_HUMAN (see all proteins) (see all similar genes):
    ZBTB7C    NFE2L1    KLHL2    ZNF295    ZNF131    Bach2
    BACH2    ZBTB16    BCL6    BCL6B    HIC1    ZBTB49
    KLHL32    ZBTB22    ZBTB25    ZBTB44    MYNN    ZBTB1

    Find genes that share paralogs with BACH1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BACH1 (see all 1335)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1925983041,2
    --21212744(+) GCCTGA/GCTAAT 1 -- us2k10--------
    rs46212391,2
    C,F--21212885(+) AGCCAC/ATGCTC 1 -- us2k14Minor allele frequency- A:0.27NA EA 244
    rs1845293551,2
    --21212979(+) TCTTAA/GCACAT 1 -- us2k10--------
    rs1126335361,2
    F--21213107(+) GGAGGG/ATCTGA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1889768851,2
    --21213153(+) AACTGA/CATAGG 1 -- us2k10--------
    rs738977451,2
    C,F--21213156(+) TGCATC/AGGTGT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1816845381,2
    --21213193(+) GCTCAA/GGGTGG 2 -- us2k10--------
    rs1166708901,2
    F--21213233(+) GTGTCT/CGCAAG 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1843326861,2
    --21213289(+) CCTGTG/TTCACT 2 -- us2k10--------
    rs738977461,2
    C,F--21213352(+) CCTACC/ATCTGG 2 -- us2k12Minor allele frequency- A:0.03WA 120

    HapMap Linkage Disequilibrium report for BACH1 (30566392 - 30816392 bp, first 250kb of BACH1)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BACH1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BACH1
    DNA2.0 Custom Variant and Variant Library Synthesis for BACH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602751    OMIM disorders: --

    3 diseases for BACH1:    
    About MalaCards
    breast cancer, early-onset    fanconi anemia, complementation group j    breast cancer


    Find genes that share disorders with BACH1           About GenesLikeMe

    2 Novoseek inferred disease relationships for BACH1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    monosomy 39.6 1 9544839 (1)
    erythroleukemia 39.4 2 14660636 (1), 15464985 (1)

    Genetic Association Database (GAD): BACH1
    Human Genome Epidemiology (HuGE) Navigator: BACH1 (36 documents)

    Export disorders for BACH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BACH1 gene, integrated from 10 sources (see all 105):
    (articles sorted by number of sources associating them with BACH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1. (PubMed id 9479503)1, 2, 3, 9 Ohira M.... Ohara O. (Genomics 1998)
    2. Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1. (PubMed id 9544839)1, 2, 3, 9 Blouin J.-L.... Antonarakis S.E. (Hum. Genet. 1998)
    3. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. (PubMed id 22158540)1, 4 Wu C....Lin D. (Nat. Genet. 2012)
    4. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    8. Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants. (PubMed id 15734732)1, 9 Dhakshinamoorthy S....Jaiswal A.K. (J. Biol. Chem. 2005)
    9. Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene. (PubMed id 14504288)1, 9 Suzuki H....Igarashi K. (J. Biol. Chem. 2003)
    10. BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite. (PubMed id 18550526)1, 9 Reichard J.F....Puga A. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 571 HGNC: 935 AceView: BACH1.1 Ensembl:ENSG00000156273 euGenes: HUgn571
    ECgene: BACH1 H-InvDB: BACH1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BACH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BACH1 gene:
    Search GeneIP for patents involving BACH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for BACH1 (BACH1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for BACH1   OriGene RNAi products in human, mouse, rat for BACH1  
     OriGene qPCR primer pairs and template standards for BACH1   OriGene Protein Over-expression Lysate for BACH1  
     OriGene MassSpec something-or-other for BACH1   OriGene clones in human, mouse for BACH1  
     OriGene qSTAR qPCR primer pairs in human, mouse for BACH1   OriGene Purified Protein for BACH1  
     OriGene ORF clones in mouse, rat for BACH1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BACH1   OriGene Custom Protein Services for BACH1  

     
     
     Block miRNA regulation of human, mouse, rat BACH1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BACH1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BACH1 Predesigned siRNA for gene silencing in human, mouse, rat BACH1
     QuantiFast Probe-based Assays in human, mouse, rat BACH1 QuantiTect SYBR Green Assays in human, mouse, rat BACH1
     PCR Arrays including human, mouse, rat BACH1 Search Chromatin IP Primers for BACH1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BACH1  GeneGlobe Interaction Network for BACH1
     Regulatory tfbs in BACH1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for BACH1 GenScript cDNA clones with any tag delivered in your preferred vector for BACH1
     GenScript Custom Assay Services for BACH1 GenScript Custom overexpressing Cell Line Services for BACH1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for BACH1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BACH1 antibodies
     BACH1 proteins
     BACH1 lysates
     Antibodies for BACH1
     See all of Abcam's Antibodies, Kits and Proteins for BACH1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for BACH1
     Antibodies for BACH1
     ELISAs for BACH1
     CLIAs for BACH1



     Browse ESI BIO Cell Lines and PureStem Progenitors for BACH1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BACH1
     SwitchGear 3'UTR luciferase reporter plasmids for BACH1
     SwitchGear Promoter luciferase reporter plasmids for BACH1
     ThermoFisher Antibodies for BACH1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BACH1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BACH1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BACH1
     LSBio Antibodies in human, mouse, rat for BACH1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for BACH1
      Search eBioscience for proteins for BACH1
      Search eBioscience for elisas for BACH1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BACH1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4