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BACE2 Gene

protein-coding GIFtS: 63

GC21P041461

beta-site APP-cleaving enzyme 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: AEPLC)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
AEPLC ^², ³
ALP56 ^¹, ², ³, ⁵
ASP1 ^², ³
ASP21 ^², ³
BAE2 ^²
CDA13 ^²
CEAP1 ^¹, ²
DRAP ^¹, ², ⁵
EC 3.4.23.45 ^³
Memapsin-1 ^³
memapsin-1 ^²

Descriptions
56 kDa aspartic-like protease ^²
Asp 1 ^³
Aspartic-like protease 56 kDa ^³
Aspartyl protease 1 ^², ³
Down region aspartic protease ^³
Down syndrome region aspartic protease ^²
Membrane-associated aspartic protease 1 ^², ³
beta secretase 2 ^²
beta-site APP-cleaving enzyme 2 ^², ³
beta-site APP-cleaving enzyme 2, EC 3.4.23 ⁹
beta-site amyloid beta A4 precursor protein-cleaving enzyme 2 ^²
transmembrane aspartic proteinase Asp1 ^²

External Ids
HGNC: 934¹
Entrez Gene: 25825²
UniProtKB: Q9Y5Z0³
Ensembl: ENSG00000182240⁷

Search outside databases for aliases for BACE2 gene

Previous GC identifers: GC21P039113 GC21P041460

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BACE2:

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's

disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by

proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein

encoded by this gene. This gene localizes to the 'Down critical region' of chromosome

21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral

membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms

have been described for this gene. [provided by RefSeq]

Gene Wiki entry for BACE2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.3

BACE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21P041461:	GeneLoc	Nature:405,311-319
Start:	41,461,598 bp from pter	28,113,408 bp from centromere
End:	41,570,394 bp from pter	28,221,077 bp from centromere
Size:	108,797 bases	107,670 bases
Orientation:	plus strand	plus strand

RefSeq DNA sequence:

NC_000021.7 NT_011512.10

Whole chromosome sequencing:
cDNA sequence:	AF050171
genomic clones:	P141D16 to P265B9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BACE2_HUMAN, Q9Y5Z0 (See protein sequence)

Recommended Name: Beta-secretase 2 precursor

Size: 518 amino acids; 56180 Da

Subunit: Interacts ith RTN3 and RTN4

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

2EWY (3D)

Secondary accessions: Q9UJT6

REFSEQ proteins (3 alternative transcripts):

NP_036237.2 NP_620476.1 NP_620477.1

ENSEMBL proteins:

ENSP00000333854 ENSP00000327528 ENSP00000332979

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BACE2 )
	Human Recombinant Proteins from Abnova (BACE2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	10677483
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	NAS	10749877

About this table

Antibodies for BACE2:

	Invitrogen Antibodies for BACE2
	Millipore Mono- and Polyclonal Antibodies for the study of BACE2
	Sigma-Aldrich Antibodies for BACE2
	R&D Systems Antibodies for BACE2 (BACE-2)
	Antibodies from Abcam (BACE2 ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BACE2)
	Novus Biologicals Antibodies for BACE2

Assays for BACE2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9Y5Z0

ProtoNet protein and cluster: Q9Y5Z0

2 Blocks protein families:

IPB001461 Pepsin (A1) aspartic protease family signature

IPB009119 Beta-site APP cleaving enzyme (BACE) family signature

UniProtKB/Swiss-Prot: BACE2_HUMAN, Q9Y5Z0

Similarity: Belongs to the peptidase A1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BACE2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BACE2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_138991

Applied Biosystems Silencer® siRNAs for BACE2

Sigma-Aldrich siRNA and siRNA Panels for BACE2

Sigma-Aldrich shRNA for BACE2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BACE2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_012105
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_012105
untagged cDNA clones in CMV expression vector (see all 5): NM_012105

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_012105

UniProtKB/Swiss-Prot: BACE2_HUMAN, Q9Y5Z0

Catalytic activity: Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu- -Asp-Ala-Glu-Phe in

the Swedish variant of Alzheimer's amyloid precursor protein

Enzyme Number (IUBMB): EC 3.4.23.45

4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Bace2):

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004190	aspartic-type endopeptidase activity	IDA	10591213
GO:0008233	peptidase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for BACE2 (Your Favorite Gene powered by Ingenuity)

Amyloid Processing
Mitochondrial Dysfunction

GeneDecks BACE2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for BACE2

5/16 Interacting proteins for BACE2 (ENSP00000332979³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APP	ENSP00000284981³	STRING (score=.978)
NCSTN	ENSP00000294785³	STRING (score=.929)
PSEN1	ENSP00000326366³	STRING (score=.927)
PSENEN	ENSP00000222266³	STRING (score=.87)
ATP6AP2	ENSP00000367697³	STRING (score=.869)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006464	protein modification process	TAS	10677483
GO:0006508	proteolysis	NAS	10749877
GO:0006509	membrane protein ectodomain proteolysis	IDA	10591213
GO:0009306	protein secretion	TAS	10677483
GO:0016486	peptide hormone processing	NAS	10749877

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for BACE2

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BACE2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BACE2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BACE2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_138991

Sigma-Aldrich siRNA and siRNA Panels for BACE2

Sigma-Aldrich shRNA for BACE2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_012105 NM_138991 NM_138992

REFSEQ mRNAs for BACE2 gene (3 alternative transcripts):

NM_012105.3 NM_138991.1 NM_138992.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_012105 NM_138991 NM_138992

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_012105
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_012105
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_012105

Additional cDNA sequence:

AF050171.1 AF117892.1 AF178532.1 AF188276.1 AF188277.1 AF200192.1 AF200342.1 AF204944.1

AK075539.1 AK130381.1 AK292056.1 AY358927.1 AY429520.1 AY429521.1 BC014453.1 CR622762.1

16 DOTS entries:

DT.95119722 DT.454692 DT.97824888 DT.100775475 DT.100030505 DT.95119750 DT.121129177 DT.91649820

DT.100030503 DT.100722222 DT.40258064 DT.80101836 DT.95125879 DT.91984794 DT.92002253 DT.92440968

24/376 AceView cDNA sequences (see all 376 ):

AW300733 BE047003 NM_138992 AA297348 AW167630 AI863003 CA489608 BC014453

AF188276 AW591148 CA487517 AW007113 AW590432 AA293614 AW264761 AI249975

BU179147 AI093100 AY358927 AI401060 CA448430 BU190511 AA430544 NM_138991

highest scoring ESTs for BACE2:

AA630313 AA011134 AA035768 AA056282 AA130245 AA156892 AA157200 AA165111 AA190800 AA369400

Unigene Cluster for BACE2:

Beta-site APP-cleaving enzyme 2

Hs.529408 [show with all ESTs]

Unigene Representative Sequence: NM_012105

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for BACE2 (see all 10 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10	^	11	^	12a	·	12b
SP1:			-		-						-				-												-						-
SP2:			-		-						-				-												-						-		-
SP3:			-		-						-				-												-		-		-		-
SP4:															-												-
SP5:											-				-				-

About this scheme

ECgene alternative splicing isoforms for BACE2

3 Ensembl transcripts including schematic representations:

ENST00000328735 ENST00000347667 ENST00000330333

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BACE2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BACE2

¹ / ² / ³

5 probe-sets matching BACE2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
57164_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AA630313	1.00	1.00	1.00	1
217867_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012105	0.60	1.00	0.82	1
222446_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF178532	0.80	1.00	0.91	1
217867_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222446_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks BACE2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTTGATGAG

SOURCE GeneReport for Unigene cluster: Hs.529408

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BACE2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BACE2¹	--	beta-site APP-cleaving enzyme 2	88.43(n) 93.25(a)	478418 XM_535595.2 XP_535595.2
chimpanzee (Pan troglodytes)	BACE2¹	--	beta-site APP-cleaving enzyme 2	99.42(n) 99.81(a)	747819 XM_001171642.1 XP_001171642.1
cow (Bos taurus)	BACE2¹	--	beta-site APP-cleaving enzyme 2	88.72(n) 92.22(a)	534774 XM_614655.3 XP_614655.3
rat (Rattus norvegicus)	Bace2¹	--	beta-site APP-cleaving enzyme 2	83.85(n) 89.69(a)	288227 NM_001002802.1 NP_001002802.1
mouse (Mus musculus)	Bace2^{1, 5}	16⁵	beta-site APP-cleaving enzyme 2^{1, 5}	84.18(n)¹ 89.49(a)¹	56175¹ NM_019517.3¹ NP_062390.2¹ AF051150⁵ AF216310⁵ (see all 21)

About this table Species with no ortholog for BACE2

ENSEMBL Gene Tree for BACE2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BACE2 gene

NAPSB² BACE1² CTSD² NAPSA²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/578 NCBI SNPs in BACE2 are shown (see all 578 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 236)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2838002^1,2	A,C,F,H,O	41570637(+)	`TTGTTT/CAGCAG`	3	--	ng3¹		10	NA EU EA WA	747
	rs12149^1,2	A,C,F,H	41569691(+)	`GGGTTT/CGTTAT`	3	--	ut3¹		16	MN EA NA EU WA	2796
	rs12482242^1,2	A,C,F,H	41570691(+)	`AACAGT/GTGTGC`	3	--	ng3¹		4	EU EA WA	376
	rs11702703^1,2	H	41569867(+)	`TCAACC/ATGGGT`	3	--	ut3¹		4	EU EA WA	418
	rs1046210^1,2	C,F,H	41544656(+)	`AGAGAC/TGAGAA`	3	D/D	syn¹ int¹		6	MN EU EA WA NA	674
	rs2837999^1,2	A,C,F,H,O	41552401(+)	`AGCTGG/ACTTTA`	3	--	int¹		7	NA EA WA	458
	rs2837984^1,2	A,C,F,H,O	41538907(+)	`AGTTAG/TATTTT`	3	--	int¹		9	NA EA EU WA	648
	rs2837970^1,2	A,C,F,H,O	41513481(+)	`TACATG/ACAAGA`	3	--	int¹		22	NA NS EU EA WA	1593
	rs2837969^1,2	A,C,F,H,O	41510247(+)	`AGATAA/TGGTTG`	3	--	int¹		7	NA EA	1840
	rs960231^1,2	A,C,F,H,O	41544527(+)	`TTTCTC/GATGTG`	3	--	int¹		15	NS NA EA EU WA	2503

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HapMap Linkage Disequilibrium images for BACE2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605668

10 Novoseek disease relationships for BACE2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
senile plaques	73.08	3	15857888 (1), 18163181 (1), 16305800 (1)
alzheimers disease	71.30	15	11032903 (2), 19124009 (1), 10931940 (1), 16816112 (1) (see all 10)
down syndrome	56.01	7	15473697 (2), 12895444 (1), 16816112 (1), 18163181 (1) (see all 6)
neuropathology	48.66	1	10965118 (1)
myositis	35.23	1	11747923 (1)
brain diseases	32.68	2	17511655 (1), 17113083 (1)
cancer	0.00	3	12611455 (2)
breast cancer	0.00	8	12611455 (5), 10838186 (1), 16305800 (1)
tumors	0.00	2	10838186 (2)
metastasis	0.00	2	10838186 (2)

About this table

Genetic Association Database: BACE2
Human Genome Epidemiology Navigator: BACE2 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/64 PubMed articles for BACE2 gene (see all 64 ):

The DNA sequence of human chromosome 21. (PubMed id 10830953)^{2, 3, 4} Hattori M....Yaspo M.L. (2000)
A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase. (PubMed id 10965118)^{1, 2, 3} Solans A.... de La Luna S. (2000)
Identification of a novel aspartic-like protease differentially expressed in human breast cancer cell lines. (PubMed id 10838186)^{1, 3, 4} Xin H.... Giese K. (2000)
Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers. (PubMed id 12707937)^{1, 3, 6} Gold G....Antonarakis S.E. (2003)
Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein. (PubMed id 16965550)^{1, 3, 4} Murayama K.S.... Araki W. (2006)
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. (PubMed id 10677483)^{1, 3, 4} Lin X.... Tang J. (2000)
Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study. (PubMed id 16023140)^{3, 6} Myllykangas L....Tienari P.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity. (PubMed id 12093293)^{3, 4} Turner R.T. III... Tang J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 25825	HGNC: 934	AceView: BACE2	Ensembl:ENSG00000182240	euGenes: HUgn25825
ECgene: BACE2	H-InvDB: BACE2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for BACE2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BACE2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BACE2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BACE2		Antibodies for BACE2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BACE2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BACE2)
	Antibodies (BACE2)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for BACE2

	Drugs for BACE2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BACE2

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BACE2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for BACE2

Summaries
for BACE2

Genomic Location
for BACE2

Proteins
for BACE2

Protein Domains/
Families
for BACE2

Gene Function
for BACE2

Pathways & Interactions
for BACE2

Drugs & Compounds
for BACE2

Transcripts
for BACE2

Expression
for BACE2

Orthologs
for BACE2

Paralogs
for BACE2

SNPs/Variants
for BACE2

Disorders & Mutations
for BACE2

Medical News
for BACE2

Publications
for BACE2

Search for BACE2

Genome Databases showing BACE2

Other Databases showing BACE2

Specialized Databases showing BACE2

Licensable Technologies
for BACE2

Services
for BACE2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BACE2 (Gene Symbol)
AEPLC
ALP56
ASP1
ASP21
BAE2
CDA13
CEAP1
DRAP
EC 3.4.23.45
Memapsin-1
memapsin-1
56 kDa aspartic-like protease
Asp 1
Aspartic-like protease 56 kDa
Aspartyl protease 1
Down region aspartic protease
Down syndrome region aspartic protease
Membrane-associated aspartic protease 1
beta secretase 2
beta-site APP-cleaving enzyme 2
beta-site APP-cleaving enzyme 2, EC 3.4.23
beta-site amyloid beta A4 precursor protein-cleaving enzyme 2
transmembrane aspartic proteinase Asp1

BACE2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor BACE2

Summariesfor BACE2

Genomic Locationfor BACE2

Proteinsfor BACE2

Protein Domains/Familiesfor BACE2

Gene Functionfor BACE2

Pathways & Interactionsfor BACE2

Drugs & Compoundsfor BACE2

Transcriptsfor BACE2

Expression for BACE2

Orthologsfor BACE2

Paralogsfor BACE2

SNPs/Variantsfor BACE2

Disorders & Mutationsfor BACE2

Medical Newsfor BACE2

Publicationsfor BACE2

Search for BACE2

Genome Databases showing BACE2

Other Databases showing BACE2

Specialized Databases showing BACE2

Licensable Technologiesfor BACE2

Servicesfor BACE2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BACE2

Summaries
for BACE2

Genomic Location
for BACE2

Proteins
for BACE2

Protein Domains/
Families
for BACE2

Gene Function
for BACE2

Pathways & Interactions
for BACE2

Drugs & Compounds
for BACE2

Transcripts
for BACE2

Expression
for BACE2

Orthologs
for BACE2

Paralogs
for BACE2

SNPs/Variants
for BACE2

Disorders & Mutations
for BACE2

Medical News
for BACE2

Publications
for BACE2

Licensable Technologies
for BACE2

Services
for BACE2