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Aliases for BACE2 Gene

Aliases for BACE2 Gene

  • Beta-Site APP-Cleaving Enzyme 2 2 3
  • ALP56 3 4 6
  • DRAP 3 4 6
  • Membrane-Associated Aspartic Protease 1 3 4
  • Aspartyl Protease 1 3 4
  • Theta-Secretase 3 4
  • Memapsin-1 3 4
  • AEPLC 3 4
  • ASP21 3 4
  • ASP1 3 4
  • Beta-Site Amyloid Beta A4 Precursor Protein-Cleaving Enzyme 2 3
  • Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 4
  • Down Syndrome Region Aspartic Protease 3
  • Transmembrane Aspartic Proteinase Asp1 3
  • Beta-Site APP Cleaving Enzyme 2 4
  • 56 KDa Aspartic-Like Protease 3
  • Aspartic-Like Protease 56 KDa 4
  • Down Region Aspartic Protease 4
  • Beta-Secretase 2 3
  • EC 4
  • EC 3.4.23 63
  • CDA13 3
  • CEAP1 3
  • Asp 1 4
  • BAE2 3

External Ids for BACE2 Gene

Previous HGNC Symbols for BACE2 Gene


Previous GeneCards Identifiers for BACE2 Gene

  • GC21P039113
  • GC21P041460
  • GC21P041461
  • GC21P042539
  • GC21P028008

Summaries for BACE2 Gene

Entrez Gene Summary for BACE2 Gene

  • This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for BACE2 Gene

BACE2 (Beta-Site APP-Cleaving Enzyme 2) is a Protein Coding gene. Diseases associated with BACE2 include down syndrome and alzheimer disease. Among its related pathways are Alzheimers Disease Pathway and Alzheimers disease. GO annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is BACE1.

UniProtKB/Swiss-Prot for BACE2 Gene

  • Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.

Gene Wiki entry for BACE2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BACE2 Gene

Genomics for BACE2 Gene

Regulatory Elements for BACE2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BACE2 Gene

41,167,801 bp from pter
41,282,534 bp from pter
114,734 bases
Plus strand

Genomic View for BACE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BACE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BACE2 Gene

Proteins for BACE2 Gene

  • Protein details for BACE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-secretase 2
    Protein Accession:
    Secondary Accessions:
    • A8K7P1
    • Q5DIH8
    • Q8N2D4
    • Q9H2V8
    • Q9NZL1
    • Q9NZL2
    • Q9UJT6

    Protein attributes for BACE2 Gene

    518 amino acids
    Molecular mass:
    56180 Da
    Quaternary structure:
    • Monomer. Interacts ith RTN3 and RTN4.

    Three dimensional structures from OCA and Proteopedia for BACE2 Gene

    Alternative splice isoforms for BACE2 Gene


neXtProt entry for BACE2 Gene

Proteomics data for BACE2 Gene at MOPED

Selected DME Specific Peptides for BACE2 Gene

Post-translational modifications for BACE2 Gene

Other Protein References for BACE2 Gene

Antibody Products

Domains for BACE2 Gene

Suggested Antigen Peptide Sequences for BACE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y5Z0
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with BACE2: view

No data available for Gene Families for BACE2 Gene

Function for BACE2 Gene

Molecular function for BACE2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu- -Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer amyloid precursor protein
UniProtKB/Swiss-Prot Function:
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
UniProtKB/Swiss-Prot Induction:
Up-regulated in primary breast and colon tumors and liver metastasis.

Enzyme Numbers (IUBMB) for BACE2 Gene

Gene Ontology (GO) - Molecular Function for BACE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IDA 10591213
genes like me logo Genes that share ontologies with BACE2: view
genes like me logo Genes that share phenotypes with BACE2: view

Animal Models for BACE2 Gene

MGI Knock Outs for BACE2:

Animal Model Products

miRNA for BACE2 Gene

miRTarBase miRNAs that target BACE2

No data available for Transcription Factor Targeting and HOMER Transcription for BACE2 Gene

Localization for BACE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BACE2 Gene

Membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.

Subcellular locations from

Jensen Localization Image for BACE2 Gene COMPARTMENTS Subcellular localization image for BACE2 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
golgi apparatus 5
plasma membrane 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BACE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IDA 11423558
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane NAS 10749877
genes like me logo Genes that share ontologies with BACE2: view

Pathways for BACE2 Gene

genes like me logo Genes that share pathways with BACE2: view

Pathways by source for BACE2 Gene

1 Qiagen pathway for BACE2 Gene
1 KEGG pathway for BACE2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BACE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 10749877
GO:0006509 membrane protein ectodomain proteolysis IDA 10591213
GO:0016486 peptide hormone processing NAS 10749877
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process IMP 12801932
genes like me logo Genes that share ontologies with BACE2: view

Compounds for BACE2 Gene

(9) ApexBio Compounds for BACE2 Gene

Compound Action Cas Number
Amyloid Beta-Peptide (12-28) (human) [107015-83-8]
Amyloid Beta-peptide (25-35) (human) Functional domain of Aβ [131602-53-4]
Amyloid β-Peptide (10-20) (human) Initiates neurodegeneration in Alzheimer disease [152286-31-2]
Amyloid β-Protein (1-15) Principal component of amyloid [183745-81-5]
Beta-Amyloid (1-11) Amyloidogenic peptide [190436-05-6]
EHT 1864 Rac family small GTPases inhibitor [754240-09-0]
EUK 134 Salen-manganese complexes;SOD mimetic [81065-76-1]
LY2886721 BACE inhibitor [1262036-50-9]
Pepstatin A Aspartic proteinases inhibitor [26305-03-3]
genes like me logo Genes that share compounds with BACE2: view

Transcripts for BACE2 Gene

Unigene Clusters for BACE2 Gene

Beta-site APP-cleaving enzyme 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BACE2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BACE2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: - - -
SP8: - -

Relevant External Links for BACE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BACE2 Gene

mRNA expression in normal human tissues for BACE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for BACE2 Gene

This gene is overexpressed in Prostate (38.7) and Pancreas (30.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BACE2 Gene

SOURCE GeneReport for Unigene cluster for BACE2 Gene Hs.529408

mRNA Expression by UniProt/SwissProt for BACE2 Gene

Tissue specificity: Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
genes like me logo Genes that share expressions with BACE2: view

Expression partners for BACE2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BACE2 Gene

Orthologs for BACE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BACE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BACE2 35
  • 88.58 (n)
  • 91.94 (a)
BACE2 36
  • 92 (a)
(Canis familiaris)
Mammalia BACE2 35
  • 88.43 (n)
  • 93.25 (a)
BACE2 36
  • 93 (a)
(Mus musculus)
Mammalia Bace2 35
  • 84.58 (n)
  • 89.7 (a)
Bace2 16
Bace2 36
  • 89 (a)
(Pan troglodytes)
Mammalia BACE2 35
  • 99.42 (n)
  • 99.81 (a)
BACE2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Bace2 35
  • 83.77 (n)
  • 89.49 (a)
(Monodelphis domestica)
Mammalia BACE2 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia BACE2 36
  • 83 (a)
(Gallus gallus)
Aves BACE2 35
  • 73.62 (n)
  • 77.7 (a)
BACE2 36
  • 77 (a)
(Anolis carolinensis)
Reptilia BACE2 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bace2 35
  • 65.56 (n)
  • 66.94 (a)
Str.2956 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68482 35
(Danio rerio)
Actinopterygii wufi26d02 35
zgc:103530 35
  • 63.37 (n)
  • 63.26 (a)
bace2 36
  • 52 (a)
BACE2 (2 of 2) 36
  • 68 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6129 35
fruit fly
(Drosophila melanogaster)
Insecta Bace 36
  • 25 (a)
CG17134 36
  • 25 (a)
CG17283 36
  • 20 (a)
CG31661 36
  • 21 (a)
CG31926 36
  • 23 (a)
CG31928 36
  • 21 (a)
CG33128 36
  • 23 (a)
CG5860 36
  • 24 (a)
CG5863 36
  • 21 (a)
CG6508 36
  • 22 (a)
pcl 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea asp-1 36
  • 20 (a)
asp-10 36
  • 17 (a)
asp-12 36
  • 22 (a)
asp-13 36
  • 19 (a)
asp-14 36
  • 17 (a)
asp-15 36
  • 20 (a)
asp-16 36
  • 19 (a)
asp-17 36
  • 20 (a)
asp-18 36
  • 20 (a)
asp-19 36
  • 20 (a)
asp-2 36
  • 15 (a)
asp-5 36
  • 22 (a)
asp-6 36
  • 23 (a)
asp-7 36
  • 19 (a)
asp-8 36
  • 15 (a)
asp-9 36
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP4 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for BACE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BACE2 Gene

Gene Tree for BACE2 (if available)
Gene Tree for BACE2 (if available)

Paralogs for BACE2 Gene

Paralogs for BACE2 Gene

Selected SIMAP similar genes for BACE2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BACE2: view

Variants for BACE2 Gene

Sequence variations from dbSNP and Humsavar for BACE2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs12149 -- 41,275,894(+) GGGTT(C/T)GTTAT utr-variant-3-prime
rs726979 -- 41,263,800(+) ctgaa(C/G)tttca intron-variant
rs726980 -- 41,263,749(+) ttacc(A/G)gtaag intron-variant
rs730513 -- 41,194,592(+) TACAA(A/G)GCCCT intron-variant
rs730514 -- 41,194,658(+) GCTGT(C/T)GCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BACE2 Gene

Variant ID Type Subtype PubMed ID
nsv7347 OTHER Inversion 18451855
nsv519019 CNV Loss 19592680
nsv3528 CNV Insertion 18451855
esv2723482 CNV Deletion 23290073
esv2723483 CNV Deletion 23290073
esv2236625 CNV Deletion 18987734
esv2723485 CNV Deletion 23290073
esv273316 CNV Insertion 20981092
esv267407 CNV Insertion 20981092
nsv187046 CNV Loss 16902084

Relevant External Links for BACE2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BACE2 Gene

Disorders for BACE2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BACE2 Gene in MalaCards »

(2) Diseases for BACE2 Gene including...

(2) University of Copenhagen DISEASES for BACE2 Gene

(10) Novoseek inferred disease relationships for BACE2 Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 71.6 12
senile plaques 71.5 3
down syndrome 57 7
neuropathology 51.9 1
myositis 32.8 1

Relevant External Links for BACE2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BACE2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for BACE2 Gene

Publications for BACE2 Gene

  1. A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase. (PMID: 10965118) Solans A. … de La Luna S. (Cytogenet. Cell Genet. 2000) 2 3 4 23
  2. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. (PMID: 10677483) Lin X. … Tang J. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23
  3. The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region. (PMID: 10683441) Acquati F. … Taramelli R. (FEBS Lett. 2000) 3 4 23
  4. Expression analysis of BACE2 in brain and peripheral tissues. (PMID: 10749877) Bennett B.D. … Vassar R. (J. Biol. Chem. 2000) 3 4 23
  5. Identification of a novel aspartic-like protease differentially expressed in human breast cancer cell lines. (PMID: 10838186) Xin H. … Giese K. (Biochim. Biophys. Acta 2000) 3 4 23

Products for BACE2 Gene

Sources for BACE2 Gene

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