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BABAM1 Gene

protein-coding   GIFtS: 50
GCID: GC19P017899

BRISC And BRCA1 A Complex Member 1

(Previous name: chromosome 19 open reading frame 62)
(Previous symbol: C19orf62)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BRISC And BRCA1 A Complex Member 11 2     Chromosome 19 Open Reading Frame 621
C19orf621 2 3     Mediator Of Rap80 Interactions And Targeting 40 KD1
MERIT402 3 5     BRCA1-A Complex Subunit MERIT402
NBA12 3 5     BRISC And BRCA1-A Complex Member 12
New Component Of The BRCA1 A Complex1 2     Mediator Of Rap80 Interactions And Targeting 40 KDa2
Mediator Of RAP80 Interactions And Targeting Subunit Of 40 KDa2 3     New Component Of The BRCAA1 A Complex2
New Component Of The BRCA1-A Complex2 3     C10orf625

External Ids:    HGNC: 250081   Entrez Gene: 290862   Ensembl: ENSG000001053937   OMIM: 6127665   UniProtKB: Q9NWV83   

Export aliases for BABAM1 gene to outside databases

Previous GC identifers: GC19P017379 GC19P017456


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BABAM1 Gene:
BABAM1 (BRISC and BRCA1 A complex member 1) is a protein-coding gene. An important paralog of this gene is ENSG00000269307.

UniProtKB/Swiss-Prot: BABA1_HUMAN, Q9NWV8
Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated
histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage
at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically
removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the
complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a
multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably
required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by
BRCC3/BRCC36 component

Gene Wiki entry for BABAM1 (C19orf62) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Search for regulatory transcription factor binding sites for BABAM1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBABAM1 promoter sequence
   Search Chromatin IP Primers for BABAM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BABAM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

BABAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BABAM1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017899:  view genomic region     (about GC identifiers)

Start:
17,378,159 bp from pter      End:
17,392,058 bp from pter
Size:
13,900 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BABA1_HUMAN, Q9NWV8 (See protein sequence)
Recommended Name: BRISC and BRCA1-A complex member 1  
Size: 329 amino acids; 36560 Da
Subunit: Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas,
BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas and
BRE/BRCC45. Component of the BRISC complex, at least composed of the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and
BABAM1/NBA1
Sequence caution: Sequence=AAF29106.1; Type=Frameshift; Positions=263;
Secondary accessions: A8MQT0 B4DRY9 B4DVR1 Q6FIA0 Q9P018
Alternative splicing: 3 isoforms:  Q9NWV8-1   Q9NWV8-2   Q9NWV8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BABAM1: NX_Q9NWV8

Explore proteomics data for BABAM1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys117, Lys126
  • Modification sites at PhosphoSitePlus

  • See BABAM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001028721.1  NP_001275685.1  NP_001275686.1  NP_054892.2  

    ENSEMBL proteins: 
     ENSP00000471605   ENSP00000469527   ENSP00000352408   ENSP00000472632   ENSP00000473182  
     ENSP00000470920   ENSP00000473240   ENSP00000471721   ENSP00000472425   ENSP00000468834  
     ENSP00000472585   ENSP00000471246   ENSP00000470088   ENSP00000470295   ENSP00000407826  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026126 BABAM1

    Graphical View of Domain Structure for InterPro Entry Q9NWV8

    ProtoNet protein and cluster: Q9NWV8

    UniProtKB/Swiss-Prot: BABA1_HUMAN, Q9NWV8
    Domain: The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the
    structure of the 19S proteasome and the BRCA1-A complexes
    Similarity: Belongs to the BABAM1 family


    Find genes that share domains with BABAM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BABA1_HUMAN, Q9NWV8
    Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated
    histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage
    at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically
    removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the
    complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a
    multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably
    required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by
    BRCC3/BRCC36 component

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with BABAM1           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BABA1_HUMAN, Q9NWV8: Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs)

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA19261749
    GO:0070531BRCA1-A complex IDA19261746
    GO:0070552BRISC complex IDA19214193

    Find genes that share ontologies with BABAM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BABAM1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32


    Find genes that share SuperPaths with BABAM1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for BABAM1
        Cell Cycle / Checkpoint Control
    DNA Damage



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BABAM1
    Interactions:

        Search GeneGlobe Interaction Network for BABAM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BABAM1 (Q9NWV81, 2, 3 ENSP000003524084) via UniProtKB, MINT, STRING, and/or I2D (see all 632)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BREQ9NXR71, 3, ENSP000003434124EBI-745725,EBI-949389 I2D: score=5 STRING: ENSP00000343412
    LRRC47Q8N1G42, 3, ENSP000003674984MINT-7945693 I2D: score=2 STRING: ENSP00000367498
    PLK1P533502, 3, ENSP000003000934MINT-7945693 I2D: score=2 STRING: ENSP00000300093
    PRKAG1P546192, 3, ENSP000003238674MINT-7945693 I2D: score=2 STRING: ENSP00000323867
    DDX39AO001482, 3, ENSP000002427764MINT-7945693 I2D: score=1 STRING: ENSP00000242776
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006302double-strand break repair IMP19261746
    GO:0010212response to ionizing radiation IMP19261748
    GO:0016568chromatin modification IEA--
    GO:0031572G2 DNA damage checkpoint IMP19261746
    GO:0045739positive regulation of DNA repair IMP19261746

    Find genes that share ontologies with BABAM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BABAM1 (BABA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BABAM1 gene (4 alternative transcripts): 
    NM_001033549.2  NM_001288756.1  NM_001288757.1  NM_014173.3  

    Unigene Cluster for BABAM1:

    BRISC and BRCA1 A complex member 1
    Hs.190722  [show with all ESTs]
    Unigene Representative Sequence: BM925343
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000598188 ENST00000594247 ENST00000359435(uc010xpl.1 uc002nfu.3 uc002nfv.3 uc010ean.2 uc002nfw.3)
    ENST00000599474 ENST00000599057 ENST00000595393 ENST00000601043 ENST00000601171
    ENST00000596335 ENST00000601436 ENST00000448635 ENST00000595632 ENST00000601938
    ENST00000602066 ENST00000598567 ENST00000598382 ENST00000601232 ENST00000447614

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      QuantiTect SYBR Green Assays in human, mouse, rat BABAM1
      QuantiFast Probe-based Assays in human, mouse, rat BABAM1

    Additional mRNA sequence: 

    AF161491.1 AK000578.1 AK025970.1 AK225047.1 AK299493.1 AK301193.1 AK308590.1 AL136692.1 
    BC000788.2 BC006244.1 BC091491.1 CR533526.1 

    Selected DOTS entries (see all 28):

    DT.452146  DT.100885589  DT.92450285  DT.100885583  DT.95170719  DT.100885576  DT.100038644  DT.121502692 
    DT.121502734  DT.100885594  DT.100885603  DT.92450295  DT.121502644  DT.100885582  DT.91790843  DT.100885579 
    DT.100885598  DT.100885599  DT.100885600  DT.121502676  DT.121502739  DT.91924895  DT.92450298  DT.95170710 

    Selected AceView cDNA sequences (see all 519):

    BQ651081 BE385619 AI337418 BU931397 AI280749 BG482237 CR609943 CB160016 
    AA877478 BM669532 BM711732 BM018703 BU849171 BM781565 AI299883 BF221507 
    BQ029774 BQ675620 AW241251 BI042872 BX283844 AW769034 CB107359 BM699313 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BABAM1 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10a ·
    SP1:                                -     -     -                                   -     -     -           -                                                   
    SP2:                          -     -     -     -                                   -     -     -           -                                                   
    SP3:                                -     -                                         -     -     -           -                                                   
    SP4:                          -     -     -                                         -     -     -           -                             -                     
    SP5:                                -     -     -                                   -                                                                           

    ExUns: 10b · 10c · 10d
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for BABAM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BABAM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATAATTTTT
    BABAM1 Expression
    About this image

    BABAM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BABAM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.190722
        Custom PCR Arrays for BABAM1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BABAM1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Babam11 , 5 RIKEN cDNA 5430437P03 gene5
    BRISC and BRCA1 A complex member 11
    83.33(n)1
    91.83(a)1
      8 (34.43 cM)5
    682511  NM_026636.21  NP_080912.21 
     713968555 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.39082 Xenopus laevis transcribed sequence with moderate similarity more 76.98(n)    CD361317.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.286302 Transcribed sequence with weak similarity to protein more 81.3(n)    AL909931.1 


    ENSEMBL Gene Tree for BABAM1 (if available)
    TreeFam Gene Tree for BABAM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BABAM1 gene
    ENSG000002693072  

    Find genes that share paralogs with BABAM1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BABAM1 (see all 352)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs129808121,2
    C,F--17377558(+) CCCAGC/GTACTT 2 -- us2k18Minor allele frequency- G:0.36NA WA 250
    rs72502661,2
    C,F,H--17377612(+) gcagtC/Gtagtt 2 -- us2k122Minor allele frequency- G:0.11NS EA NA CSA WA 2752
    rs1498042801,2
    --17377636(+) GATACC/TCTGTC 2 -- us2k10--------
    rs1457372251,2
    --17377770(+) TATATG/TTAAAA 2 -- us2k10--------
    rs1150408071,2
    C,F--17377903(+) TTCCCT/CAAATC 2 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1485315291,2
    --17377904(+) TCCCTA/GAATCG 2 -- us2k10--------
    rs1919964311,2
    --17378008(+) TGATTC/TGGCCA 2 -- us2k10--------
    rs1379698981,2
    C--17378018(+) AAAAC-/AAAAAA 2 -- us2k10--------
    rs1434271741,2
    --17378065(+) TTGCTA/CCAGTG 2 -- us2k10--------
    rs1119053451,2
    F--17378095(+) TCCCGG/CCGCAC 2 -- us2k11Minor allele frequency- C:0.50CSA 2

    HapMap Linkage Disequilibrium report for BABAM1 (17378159 - 17392058 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BABAM1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911199CNV Loss21882294
    dgv3760n71CNV Loss21882294
    nsv911182CNV Loss21882294
    dgv3757n71CNV Loss21882294
    nsv911198CNV Loss21882294
    nsv515965CNV Loss19592680
    nsv911188CNV Loss21882294
    nsv911185CNV Loss21882294
    nsv911200CNV Loss21882294
    nsv470129CNV Loss18288195

    Human Gene Mutation Database (HGMD): BABAM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BABAM1
    DNA2.0 Custom Variant and Variant Library Synthesis for BABAM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612766    OMIM disorders: --


    Find genes that share disorders with BABAM1           About GenesLikeMe


    Export disorders for BABAM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BABAM1 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with BABAM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    2. MERIT40 facilitates BRCA1 localization and DNA damage repair. (PubMed id 19261748)1, 2 Feng L.... Chen J. (Genes Dev. 2009)
    3. MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. (PubMed id 19261746)1, 2 Shao G.... Greenberg R.A. (Genes Dev. 2009)
    4. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. (PubMed id 19261749)1, 2 Wang B.... Elledge S.J. (Genes Dev. 2009)
    5. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC- associated Brcc36 and proteasomal Poh1. (PubMed id 19214193)1, 2 Cooper E.M....Cohen R.E. (EMBO J. 2009)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    7. Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. (PubMed id 23544013)1 Couch F.J....Antoniou A.C. (PLoS Genet. 2013)
    8. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (Nat. Genet. 2013)
    9. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. (PubMed id 23535733)1 Garcia-Closas M....Kraft P. (Nat. Genet. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29086 HGNC: 25008 AceView: HSPC142 Ensembl:ENSG00000105393 euGenes: HUgn29086
    ECgene: BABAM1 H-InvDB: BABAM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BABAM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BABAM1 gene:
    Search GeneIP for patents involving BABAM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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