Aliases for BABAM1 Gene
External Ids for BABAM1 Gene
Previous HGNC Symbols for BABAM1 Gene
Previous GeneCards Identifiers for BABAM1 Gene
GeneCards Summary for BABAM1 Gene
BABAM1 (BRISC And BRCA1 A Complex Member 1) is a Protein Coding gene. Diseases associated with BABAM1 include cherubism. Among its related pathways are Cell Cycle, Mitotic and DNA Damage. An important paralog of this gene is ENSG00000269307.
UniProtKB/Swiss-Prot for BABAM1 Gene
Component of the BRCA1-A complex, a complex that specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the Lys-63-linked deubiquitinase activity mediated by BRCC3/BRCC36 component.