BAALC Gene
protein-coding GIFtS : 52
GCID: GC08 P104152
brain and acute leukemia, cytoplasmic
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Aliasesfor BAALC gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Brain And Acute Leukemia, Cytoplasmic 1 2 Brain And Acute Leukemia Cytoplasmic Protein2
Export aliases for BAALC gene to outside databases Previous GC identifers: GC08P103158 GC08P104221 GC08P103821 GC08P104109 GC08P104222 GC08P099353
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Summariesfor BAALC gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for BAALC : This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML). The gene is conserved among mammals and is not found in lower organisms. Tissues that express this gene develop from the neuroectoderm. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: BAALC_HUMAN, Q8WXS3 Function : May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A (By similarity)
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Genomic Viewsfor BAALC gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000008.10 NC_018919.1 NT_008046.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the BAALC gene promoter: AML1a Other transcription factors Search SABiosciences Chromatin IP Primers for BAALC Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAALC
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 8q22.3 Ensembl cytogenetic band: 8q22.3 HGNC cytogenetic band: 8q22.3 BAALC Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08P104152: view genomic region
(about GC identifiers )
Start:
104,152,921 bp from pter
End:
104,242,533 bp from pter
Size:
89,613 bases
Orientation:
plus strand
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Proteinsfor BAALC gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: BAALC_HUMAN, Q8WXS3 (See
protein sequence )Recommended Name: Brain and acute leukemia cytoplasmic protein Size : 180 amino acids; 19224 Da
Subunit : Interacts with CAMK2A (By similarity)
Subcellular location : Cytoplasm. Membrane. Note=Postsynaptic lipid rafts (By similarity)
Secondary accessions : Q8WTP6 Q8WXS0 Q8WXS1 Q8WXS2 Q9HA93Alternative splicing : 6 isoforms : Q8WXS3-1 Q8WXS3-2 Q8WXS3-3 Q8WXS3-4 Q8WXS3-5 Q8WXS3-6 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for BAALC: NX_Q8WXS3 Post-translational modifications:
Palmitoylation and myristoylation target the protein to the lipid rafts (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8WXS3 BAALC Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001019543.1 NP_079088.1 ENSEMBL proteins: ENSP00000312457 ENSP00000395024 ENSP00000297574 ENSP00000302559 ENSP00000331579 Human Recombinant Protein Products: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
BAALC for ontologies About GeneDecksing BAALC Antibody Products: Assay Products for BAALC:
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Protein
Domains / Familiesfor BAALC gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
BAALC for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q8WXS3 ProtoNet protein and cluster: Q8WXS3
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Functionfor BAALC gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: BAALC_HUMAN, Q8WXS3 Function : May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for BAALC (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for BAALC (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): BAALC (NM_024812 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BAALC Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat BAALC
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAALC
1 GenomeRNAi human phenotype for BAALC :
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Pathways & Interactionsfor BAALC gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BAALC STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for BAALC (Q8WXS3 2 , 3 ENSP00000312457 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor BAALC gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for BAALC Search CenterWatch for drugs/clinical trials and news about BAALC
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Transcriptsfor BAALC gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for BAALC gene (2 alternative transcripts): NM_001024372.1 NM_024812.2 Unigene Cluster for BAALC:
Brain and acute leukemia, cytoplasmic Hs.533446 [show with all ESTs ] Unigene Representative Sequence: NM_024812 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000309982 (uc003yld.3 uc003yle.3 ) ENST00000438105 (uc010mcc.3 )ENST00000297574 ENST00000306391 ENST00000330955 ENST00000519507 ENST00000517863 ENST00000523754 ENST00000521926 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for BAALC (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for BAALC (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): BAALC (NM_024812 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BAALC Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat BAALC
Additional cDNA sequence: AF371319.1 AF371323.1 AK022077.1 AK093819.1 AK310816.1 BC011517.1 BC014365.1 BC035038.2
10 DOTS entries : DT.443046 DT.95092573
DT.91918803 DT.100778235 DT.121479093 DT.121479250 DT.426517 DT.95092568 DT.95092571 DT.95092599 24/227 AceView cDNA sequences (see all 227 ):
F12256 T33369 CR607637 BQ575423 BQ672359 T33887 Z44866 AI869984 CA424634 AW149362 R38507 BC035038 CA416942 T33437 BQ883985 BM717611 F04032 F04812 AI361572 BQ447214 CB153952 F05239 BM509802 AW292237 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for BAALC About this scheme ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c SP1 :     -   -   -   -         SP2 :         -           SP3 :     -   -             SP4 :         -   -        
ECgene alternative splicing isoforms for BAALC
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Expression for BAALC gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section BAALC expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TATGTATGAG
About this image BAALC expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See BAALC Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for BAALC SOURCE GeneReport for Unigene cluster: Hs.533446 UniProtKB/Swiss-Prot: BAALC_HUMAN, Q8WXS3 Tissue specificity : Expressed by neural and hematopoietic cells. Expression is found both in normal early progenitorcells and in the most immature type of blasts in acute leukemia but not in mature hematopoietic cells. Isoform 2 and isoform 6 are expressed in the brain. Isoform 2 shows a low expression in neuroectoderm-derived tissues such as adrenal gland and no expression in bone marrow, peripheral blood lymphocytes or lymph nodes, or in tumors or cancer cell lines of nonneural tissue origin SABiosciences Expression via Pathway-Focused PCR Array including BAALC : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for BAALCBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat BAALC QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat BAALC QIAGEN QuantiFast Probe-based Assays in human , mouse , rat BAALC In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAALC
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Orthologsfor BAALC gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for BAALC gene from 3/8 species (see all 8 ) About this table
ENSEMBL Gene Tree for BAALC (if available)TreeFam Gene Tree for BAALC (if available)
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Paralogsfor BAALC gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor BAALC gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 8 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for BAALC (104152921 - 104242533 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for BAALC 1 CNV : 65217 Human Gene Mutation Database (HGMD) : BAALC SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing BAALC
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Disorders
/ Diseasesfor BAALC gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
BAALC for disorders About GeneDecksing
OMIM gene information: 606602
OMIM disorders : --8 diseases for BAALC : About MalaCards acute myeloid leukemia myeloid leukemia leukemia acute leukemia acute lymphoblastic leukemia lymphoblastic leukemia chronic myeloid leukemia hematopoiesis 1 disease from the University of Copenhagen DISEASES database for BAALC :Acute myeloid leukemia Export disorders for BAALC gene to outside databases
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Publicationsfor BAALC gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for BAALC gene, integrated from 9 sources (see all 25 ): (articles sorted by number of sources associating them with BAALC) Utopia : connect your pdf to the dynamic world of online information
BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia. (PubMed id 11707601) 1 , 2 , 3 Tanner S.M.... de La Chapelle A. (2001) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) miR-3151 interplays with its host gene BAALC and indep endently affects outcome of patients with cytogenetically normal acute myeloid l eukemia. (PubMed id 22529287) 1 Eisfeld A.K....Bloomfield C.D. (2012) Histone post-translational modifications associated to BAALC expression in leukemic cells. (PubMed id 22197554) 1 Franzoni A....Damante G. (2012) Prognostic significance of combined MN1, ERG, BAALC, a nd EVI1 (MEBE) expression in patients with myelodysplastic syndromes. (PubMed id 22488406) 1 Thol F....Heuser M. (2012) Heritable polymorphism predisposes to high BAALC expre ssion in acute myeloid leukemia. (PubMed id 22493267) 1 Eisfeld A.K....de la Chapelle A. (2012) Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BA ALC expression: a GRAALL study. (PubMed id 21835957) 1 Ben Abdelali R....Ifrah N. (2011) Presence of FLT3-ITD and high BAALC expression are in dependent prognostic markers in childhood acute myeloid leukemia. (PubMed id 21967978) 1 Staffas A....Ehrencrona H. (2011) BAALC and ERG expression in acute myeloid leukemia wi th normal karyotype: impact on prognosis. (PubMed id 19555438) 1 Eid M.A....Mahmoud L. (2010)
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External Searches for BAALC gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing BAALC gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing BAALC gene
(According to HUGE )
About This Section --
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Specialized Databases showing BAALC gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for BAALC gene: Search GeneIP for patents involving BAALC GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor BAALC gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for BAALC OriGene shRNA RFP for BAALC OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for BAALC OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for BAALC OriGene Protein Over-expression Lysate for BAALC Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for BAALC OriGene 3'-UTR Clone for BAALC OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for BAALC OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for BAALC Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for BAALC OriGene Custom Protein Services for BAALC OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BAALC QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing BAALC QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BAALC QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat BAALC QIAGEN QuantiFast Probe-based Assays in human , mouse , rat BAALC QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat BAALC
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Recombinant Protein for BAALC
BAALC Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BAALC
ThermoFisher Antibodies for BAALC
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat BAALC
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Aliases for BAALC
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Disorders / Diseases for BAALC
Domains / Families for BAALC
Drugs / Compounds for BAALC
Expression for BAALC
Function for BAALC
Genomic Views for BAALC
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Pathways / Interactions for BAALC
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Transcripts for BAALC
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