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Aliases for BAALC Gene

Aliases for BAALC Gene

  • Brain And Acute Leukemia, Cytoplasmic 2 3

External Ids for BAALC Gene

Summaries for BAALC Gene

Entrez Gene Summary for BAALC Gene

  • This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML). The gene is conserved among mammals and is not found in lower organisms. Tissues that express this gene develop from the neuroectoderm. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAALC Gene

BAALC (Brain And Acute Leukemia, Cytoplasmic) is a Protein Coding gene. Diseases associated with BAALC include acute leukemia and myeloid leukemia.

UniProtKB/Swiss-Prot for BAALC Gene

  • May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAALC Gene

Genomics for BAALC Gene

Genomic Location for BAALC Gene

Start:
103,140,693 bp from pter
End:
103,230,305 bp from pter
Size:
89,613 bases
Orientation:
Plus strand

Genomic View for BAALC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAALC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAALC Gene

Regulatory Elements for BAALC Gene

Transcription factor binding sites by QIAGEN in the BAALC gene promoter:

Proteins for BAALC Gene

  • Protein details for BAALC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXS3-BAALC_HUMAN
    Recommended name:
    Brain and acute leukemia cytoplasmic protein
    Protein Accession:
    Q8WXS3
    Secondary Accessions:
    • Q8WTP6
    • Q8WXS0
    • Q8WXS1
    • Q8WXS2
    • Q9HA93

    Protein attributes for BAALC Gene

    Size:
    180 amino acids
    Molecular mass:
    19224 Da
    Quaternary structure:
    • Interacts with CAMK2A.

    Alternative splice isoforms for BAALC Gene

neXtProt entry for BAALC Gene

Proteomics data for BAALC Gene at MOPED

Post-translational modifications for BAALC Gene

  • Palmitoylation and myristoylation target the protein to the lipid rafts.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BAALC Gene

No data available for DME Specific Peptides for BAALC Gene

Domains for BAALC Gene

Protein Domains for BAALC Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with BAALC: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BAALC Gene

Function for BAALC Gene

Molecular function for BAALC Gene

UniProtKB/Swiss-Prot Function: May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A.

Phenotypes for BAALC Gene

GenomeRNAi human phenotypes for BAALC:
genes like me logo Genes that share phenotypes with BAALC: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BAALC Gene

Localization for BAALC Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAALC Gene

Cytoplasm. Membrane. Note=Postsynaptic lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAALC Gene COMPARTMENTS Subcellular localization image for BAALC gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BAALC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11707601
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with BAALC: view

Pathways for BAALC Gene

SuperPathways for BAALC Gene

No Data Available

Interacting Proteins for BAALC Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000312457%0d%0a9606.ENSP00000244769%0d%0a
Selected Interacting proteins: Q8WXS3-BAALC_HUMAN ENSP00000312457 for BAALC Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for BAALC Gene

None

No data available for Pathways by source for BAALC Gene

Transcripts for BAALC Gene

Unigene Clusters for BAALC Gene

Brain and acute leukemia, cytoplasmic:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BAALC Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for BAALC Gene

GeneLoc Exon Structure for
BAALC
ECgene alternative splicing isoforms for
BAALC

Expression for BAALC Gene

mRNA expression in normal human tissues for BAALC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BAALC Gene

This gene is overexpressed in Brain - Cortex (5.1), Brain - Putamen (basal ganglia) (5.1), Brain - Frontal Cortex (BA9) (5.0), Brain - Anterior cingulate cortex (BA24) (4.8), Brain - Caudate (basal ganglia) (4.7), Brain - Amygdala (4.4), Brain - Hippocampus (4.2), and Brain - Substantia nigra (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for BAALC Gene

SOURCE GeneReport for Unigene cluster for BAALC Gene Hs.533446

mRNA Expression by UniProt/SwissProt for BAALC Gene

Q8WXS3-BAALC_HUMAN
Tissue specificity: Expressed by neural and hematopoietic cells. Expression is found both in normal early progenitor cells and in the most immature type of blasts in acute leukemia but not in mature hematopoietic cells. Isoform 2 and isoform 6 are expressed in the brain. Isoform 2 shows a low expression in neuroectoderm-derived tissues such as adrenal gland and no expression in bone marrow, peripheral blood lymphocytes or lymph nodes, or in tumors or cancer cell lines of nonneural tissue origin.
genes like me logo Genes that share expressions with BAALC: view

Orthologs for BAALC Gene

This gene was present in the common ancestor of chordates.

Orthologs for BAALC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAALC 36
  • 96.4 (n)
  • 95.5 (a)
BAALC 37
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAALC 36
  • 90.57 (n)
  • 84.83 (a)
BAALC 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAALC 36
  • 90.57 (n)
  • 84.83 (a)
BAALC 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Baalc 36
  • 86.44 (n)
  • 83.45 (a)
Baalc 16
Baalc 37
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BAALC 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Baalc 36
  • 87.13 (n)
  • 83.45 (a)
chicken
(Gallus gallus)
Aves BAALC 36
  • 66.18 (n)
  • 56.52 (a)
BAALC 37
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia baalc 36
  • 57.58 (n)
  • 55.24 (a)
zebrafish
(Danio rerio)
Actinopterygii BAALC 37
  • 32 (a)
OneToOne
Species with no ortholog for BAALC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAALC Gene

ENSEMBL:
Gene Tree for BAALC (if available)
TreeFam:
Gene Tree for BAALC (if available)

Paralogs for BAALC Gene

No data available for Paralogs for BAALC Gene

Variants for BAALC Gene

Sequence variations from dbSNP and Humsavar for BAALC Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs713368 -- 103,184,485(-) TTGGG(A/G)GATGC intron-variant
rs713369 -- 103,184,688(-) CTCCC(A/T)CCCAT intron-variant
rs768380 -- 103,199,253(-) gtgca(C/G)gtaaa intron-variant
rs903299 -- 103,155,999(-) AGTAG(C/T)TGCAA intron-variant
rs954782 -- 103,175,740(+) AGCTC(A/G)AACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAALC Gene

Variant ID Type Subtype PubMed ID
nsv831413 CNV Gain 17160897
esv21700 CNV Gain 19812545
esv2678140 CNV Deletion 23128226

Relevant External Links for BAALC Gene

HapMap Linkage Disequilibrium report
BAALC
Human Gene Mutation Database (HGMD)
BAALC

Disorders for BAALC Gene

(1) University of Copenhagen DISEASES for BAALC Gene

Relevant External Links for BAALC

Genetic Association Database (GAD)
BAALC
genes like me logo Genes that share disorders with BAALC: view

No data available for UniProtKB/Swiss-Prot for BAALC Gene

Publications for BAALC Gene

  1. BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia. (PMID: 11707601) Tanner S.M. … de La Chapelle A. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal cytogenetics. (PMID: 15604894) Marcucci G. … Bloomfield C.D. (Curr. Opin. Hematol. 2005) 3
  5. Baalc, a marker of mesoderm and muscle. (PMID: 15749074) Satoskar A.A. … de la Chapelle A. (Gene Expr. Patterns 2005) 3

Products for BAALC Gene

Sources for BAALC Gene

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