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Aliases for BAALC Gene

Aliases for BAALC Gene

  • Brain And Acute Leukemia, Cytoplasmic 2 3 5

External Ids for BAALC Gene

Previous GeneCards Identifiers for BAALC Gene

  • GC08P103158
  • GC08P104221
  • GC08P103821
  • GC08P104109
  • GC08P104222
  • GC08P104152
  • GC08P099353

Summaries for BAALC Gene

Entrez Gene Summary for BAALC Gene

  • This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML). The gene is conserved among mammals and is not found in lower organisms. Tissues that express this gene develop from the neuroectoderm. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAALC Gene

BAALC (Brain And Acute Leukemia, Cytoplasmic) is a Protein Coding gene. Diseases associated with BAALC include Acute Leukemia and Leukemia.

UniProtKB/Swiss-Prot for BAALC Gene

  • May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAALC Gene

Genomics for BAALC Gene

Regulatory Elements for BAALC Gene

Enhancers for BAALC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BAALC on UCSC Golden Path with GeneCards custom track

Promoters for BAALC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BAALC on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the BAALC gene promoter:

Genomic Location for BAALC Gene

103,140,693 bp from pter
103,230,305 bp from pter
89,613 bases
Plus strand

Genomic View for BAALC Gene

Genes around BAALC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAALC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAALC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAALC Gene

Proteins for BAALC Gene

  • Protein details for BAALC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Brain and acute leukemia cytoplasmic protein
    Protein Accession:
    Secondary Accessions:
    • Q8WTP6
    • Q8WXS0
    • Q8WXS1
    • Q8WXS2
    • Q9HA93

    Protein attributes for BAALC Gene

    180 amino acids
    Molecular mass:
    19224 Da
    Quaternary structure:
    • Interacts with CAMK2A.

    Alternative splice isoforms for BAALC Gene

neXtProt entry for BAALC Gene

Proteomics data for BAALC Gene at MOPED

Post-translational modifications for BAALC Gene

  • Palmitoylation and myristoylation target the protein to the lipid rafts.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BAALC Gene

No data available for DME Specific Peptides for BAALC Gene

Domains & Families for BAALC Gene

Protein Domains for BAALC Gene


Suggested Antigen Peptide Sequences for BAALC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BAALC: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BAALC Gene

Function for BAALC Gene

Molecular function for BAALC Gene

UniProtKB/Swiss-Prot Function:
May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A.

Phenotypes for BAALC Gene

GenomeRNAi human phenotypes for BAALC:
genes like me logo Genes that share phenotypes with BAALC: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BAALC

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BAALC Gene

Localization for BAALC Gene

Subcellular locations from UniProtKB/Swiss-Prot for BAALC Gene

Cytoplasm. Membrane. Note=Postsynaptic lipid rafts. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for BAALC Gene COMPARTMENTS Subcellular localization image for BAALC gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BAALC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11707601
genes like me logo Genes that share ontologies with BAALC: view

Pathways & Interactions for BAALC Gene

SuperPathways for BAALC Gene

No Data Available

Interacting Proteins for BAALC Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8WXS3-BAALC_HUMAN ENSP00000312457 for BAALC Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for BAALC Gene


No data available for Pathways by source and SIGNOR curated interactions for BAALC Gene

Drugs & Compounds for BAALC Gene

No Compound Related Data Available

Transcripts for BAALC Gene

Unigene Clusters for BAALC Gene

Brain and acute leukemia, cytoplasmic:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BAALC Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for BAALC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BAALC Gene

mRNA expression in normal human tissues for BAALC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BAALC Gene

This gene is overexpressed in Brain - Cortex (x5.1), Brain - Putamen (basal ganglia) (x5.1), Brain - Frontal Cortex (BA9) (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.8), Brain - Caudate (basal ganglia) (x4.7), Brain - Amygdala (x4.4), Brain - Hippocampus (x4.2), and Brain - Substantia nigra (x4.0).

Protein differential expression in normal tissues from HIPED for BAALC Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BAALC Gene

SOURCE GeneReport for Unigene cluster for BAALC Gene Hs.533446

mRNA Expression by UniProt/SwissProt for BAALC Gene

Tissue specificity: Expressed by neural and hematopoietic cells. Expression is found both in normal early progenitor cells and in the most immature type of blasts in acute leukemia but not in mature hematopoietic cells. Isoform 2 and isoform 6 are expressed in the brain. Isoform 2 shows a low expression in neuroectoderm-derived tissues such as adrenal gland and no expression in bone marrow, peripheral blood lymphocytes or lymph nodes, or in tumors or cancer cell lines of nonneural tissue origin.
genes like me logo Genes that share expression patterns with BAALC: view

Protein tissue co-expression partners for BAALC Gene

- Elite partner

Primer Products

Orthologs for BAALC Gene

This gene was present in the common ancestor of chordates.

Orthologs for BAALC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BAALC 35
  • 90.57 (n)
  • 84.83 (a)
  • 85 (a)
(Canis familiaris)
Mammalia BAALC 35
  • 90.57 (n)
  • 84.83 (a)
  • 84 (a)
(Mus musculus)
Mammalia Baalc 35
  • 86.44 (n)
  • 83.45 (a)
Baalc 16
Baalc 36
  • 61 (a)
(Pan troglodytes)
Mammalia BAALC 35
  • 96.4 (n)
  • 95.5 (a)
  • 78 (a)
(Rattus norvegicus)
Mammalia Baalc 35
  • 87.13 (n)
  • 83.45 (a)
(Monodelphis domestica)
Mammalia BAALC 36
  • 63 (a)
(Gallus gallus)
Aves BAALC 35
  • 66.18 (n)
  • 56.52 (a)
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia baalc 35
  • 57.58 (n)
  • 55.24 (a)
(Danio rerio)
Actinopterygii BAALC 36
  • 32 (a)
Species with no ortholog for BAALC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAALC Gene

Gene Tree for BAALC (if available)
Gene Tree for BAALC (if available)

Paralogs for BAALC Gene

No data available for Paralogs for BAALC Gene

Variants for BAALC Gene

Sequence variations from dbSNP and Humsavar for BAALC Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_056741 -
rs2088036 -- 103,178,526(+) CTGTA(C/G)GATTT intron-variant
rs2201369 -- 103,209,797(+) tgcct(C/T)tggat intron-variant
rs2201370 -- 103,213,308(+) TTAAG(C/T)ACAGC intron-variant
rs2220824 -- 103,213,516(+) GGTGG(A/G)CATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAALC Gene

Variant ID Type Subtype PubMed ID
nsv831413 CNV Gain 17160897
esv21700 CNV Gain 19812545
esv2678140 CNV Deletion 23128226

Variation tolerance for BAALC Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BAALC Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAALC Gene

Disorders for BAALC Gene

MalaCards: The human disease database

(3) MalaCards diseases for BAALC Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute leukemia
  • stem cell leukaemia
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search BAALC in MalaCards View complete list of genes associated with diseases

Relevant External Links for BAALC

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BAALC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BAALC Gene

Publications for BAALC Gene

  1. BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia. (PMID: 11707601) Tanner S.M. … de La Chapelle A. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 67
  2. Overexpression of BAALC: clinical significance in Chinese de novo acute myeloid leukemia. (PMID: 25428390) Zhou J.D. … Qian J. (Med. Oncol. 2015) 3
  3. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3
  4. Combined assessment of WT1 and BAALC gene expression at diagnosis may improve leukemia-free survival prediction in patients with myelodysplastic syndromes. (PMID: 26012361) Minetto P. … Miglino M. (Leuk. Res. 2015) 3
  5. BAALC potentiates oncogenic ERK pathway through interactions with MEKK1 and KLF4. (PMID: 26050649) Morita K. … Kurokawa M. (Leukemia 2015) 3

Products for BAALC Gene

Sources for BAALC Gene