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BAALC Gene

protein-coding   GIFtS: 53

GC08P104222
brain and acute leukemia, cytoplasmic
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ12015 2
Descriptions
brain and acute leukemia, cytoplasmic 2
External Ids
HGNC: 143331
Entrez Gene: 798702
UniProtKB: Q8WXS33
Ensembl: ENSG000001649297
Search outside databases for aliases for BAALC gene

Previous GC identifers: GC08P103158 GC08P104221 GC08P103821 GC08P104109

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BAALC:
This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML).
The gene is conserved among mammals and is not found in lower organisms. Tissues that express this
gene develop from the neuroectoderm. Multiple alternatively spliced transcript variants that
encode different proteins have been described for this gene; however, some of the transcript
variants are found only in AML cell lines. [provided by RefSeq]

UniProtKB/Swiss-Prot: BAALC_HUMAN, Q8WXS3
Function: May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A (By
similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BAALC gene  

Entrez Gene cytogenetic band: 8q22.3   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22.3

BAALC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P104222:     (about GC identifiers)

Start:
104,222,097 bp from pter
End:
104,311,709 bp from pter
Size:
89,613 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000008.9  NT_008046.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BAALC_HUMAN, Q8WXS3 (See protein sequence)
Recommended Name: Brain and acute leukemia cytoplasmic protein  
Size: 180 amino acids; 19224 Da
Subunit: Interacts with CAMK2A (By similarity)
Subcellular location: Cytoplasm. Membrane. Note=Postsynaptic lipid rafts (By similarity)
Secondary accessions: Q8WTP6 Q8WXS0 Q8WXS1 Q8WXS2 Q9HA93
Alternative splicing: 6 isoforms:  Q8WXS3-1   Q8WXS3-2   Q8WXS3-3   Q8WXS3-4   Q8WXS3-5   Q8WXS3-6   

Post-translational modifications:

  • Palmitoylation and myristoylation target the protein to the lipid rafts (By similarity)1


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001019543.1  NP_079088.1  


    ENSEMBL proteins: 
    ENSP00000297574 ENSP00000331579 ENSP00000379202 ENSP00000302559 ENSP00000312457 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (BAALC)
    Human Recombinant Proteins from Abnova (BAALC)
                  OriGene Purified Recombinant Human Protein: BAALC 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0016020 membrane IEA--
    About this table

    Antibodies for BAALC: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (BAALC), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (BAALC)
    Novus Biologicals Antibodies for BAALC

    Assays for BAALC: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR009728 BAALC


       GeneDecks  BAALC for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8WXS3

    ProtoNet protein and cluster: Q8WXS3

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BAALC)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_024812

                  Applied Biosystems Silencer® siRNAs for BAALC

                  Sigma-Aldrich siRNA for BAALC  
                         Sigma-Aldrich shRNA for BAALC  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for BAALC
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001024372
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001024372
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001024372 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_024812

    UniProtKB/Swiss-Prot: BAALC_HUMAN, Q8WXS3
    Function: May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A (By
    similarity)

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5 Interacting proteins for BAALC (ENSP000002975743 Q8WXS32) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997502MINT-67748
    PTHENSP000002820913STRING (score=.843)
    CD34ENSP000003100363STRING (score=.779)
    FLT3ENSP000003703693STRING (score=.748)
    NPM1ENSP000002969303STRING (score=.736)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for BAALC

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BAALC)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_024812

                  Sigma-Aldrich siRNA for BAALC  
                         Sigma-Aldrich shRNA for BAALC  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001024372  NM_024812  

    REFSEQ mRNAs for BAALC gene (2 alternative transcripts): 

    NM_001024372.1   NM_024812.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001024372  NM_024812  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001024372
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001024372
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001024372 

    Additional cDNA sequence: 

    AF371319.1 AF371323.1 AK022077.1 AK093819.1 AK310816.1 BC011517.1 BC014365.1 BC035038.2 
    CR597062.1 CR606691.1 CR607637.1 CR613048.1 CR615298.1 

    10 DOTS entries:

    DT.443046  DT.95092573  DT.91918803  DT.121479250  DT.100778235  DT.121479093  DT.426517  DT.95092568 
    DT.95092571  DT.95092599 

    24/227 AceView cDNA sequences (see all 227 ):

    H89981 F02839 T33370 BI822259 CB054175 AW149362 Z45132 BC035038 
    F05239 AK093819 CR597062 R37607 F02877 AI356854 BM717611 BM927193 
    AI197813 AU120917 CR606691 T33369 CR613048 BQ447214 BM509802 F06570 

    highest scoring ESTs for BAALC:

    R60867 AA350529 AA351829 AA487577 AA488701 AA602607 AA663372 AA877472 AA903735 AA984630 

    Unigene Cluster for BAALC:

    Brain and acute leukemia, cytoplasmic
    Hs.533446  [show with all ESTs]
    Unigene Representative Sequence: NM_024812


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BAALC

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:              -     -     -     -                     
    SP2:                          -                           
    SP3:              -     -                                 
    SP4:                          -     -                     

    About this scheme

    ECgene alternative splicing isoforms for BAALC

    5 Ensembl transcripts including schematic representations:
    ENST00000297574  ENST00000330955  ENST00000395861  ENST00000306391  ENST00000309982  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    BAALC expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for BAALC

    1 / 2 / 3

    5 probe-sets matching BAALC gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    44734_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 R60867 1.00 1.00 1.00 1

    218899_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_024812 0.60 1.00 0.82 1

    222780_s_at2, 3 U133-B 1 1.00 1.00 -- -- AI870583 0.80 1.00 0.91 1

    218899_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    222780_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  BAALC for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TATGTATGAG

    SOURCE GeneReport for Unigene cluster: Hs.533446

    UniProtKB/Swiss-Prot: BAALC_HUMAN, Q8WXS3
    Tissue specificity: Expressed by neural and hematopoietic cells. Expression is found both in normal
    early progenitor cells and in the most immature type of blasts in acute leukemia but not in mature
    hematopoietic cells. Isoform 2 and isoform 6 are expressed in the brain. Isoform 2 shows a low
    expression in neuroectoderm-derived tissues such as adrenal gland and no expression in bone
    marrow, peripheral blood lymphocytes or lymph nodes, or in tumors or cancer cell lines of
    nonneural tissue origin

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for BAALC gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    BAALC1   -- brain and acute leukemia, cytoplasmic 90.57(n)
    84.83(a)
    612780  XM_844459.1  XP_849552.1 
    chimpanzee
    (Pan troglodytes)
    BAALC1   -- brain and acute leukemia, cytoplasmic 97.7(n)
    96.55(a)
    742690  XM_001155440.1  XP_001155440.1 
    cow
    (Bos taurus)
    BAALC1   -- brain and acute leukemia, cytoplasmic 90.57(n)
    84.83(a)
    614130  XM_865500.2  XP_870593.2 
    rat
    (Rattus norvegicus)
    Baalc1   -- brain and acute leukemia, cytoplasmic 87.13(n)
    83.45(a)
    140720  NM_144762.2  NP_658907.1 
    mouse
    (Mus musculus)
    Baalc1, 5 15 (16.00 cM)5
    brain and acute leukemia, cytoplasmic1, 5 86.44(n)1
    83.45(a)1
    1184521  NM_080640.41  NP_542371.11 
     AF3713205  AF3713245  (see all 15)
    About this table        Species with no ortholog for BAALC

    ENSEMBL Gene Tree for BAALC
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/158 NCBI SNPs in BAALC are shown (see all 158 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 187)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs22561641,2
    A,C,F,H104220557(+) TAGGGC/AAGCCA 2 -- ng517Minor allele frequency- A:0.47EA EU WA NA 1350
    rs70140081,2
    A,F,H104221267(+) ACCCCC/GCTCTT 2 -- ng51 trp34Minor allele frequency- G:0.10EU EA WA 418
    rs22561581,2
    C,F,H104220699(+) TGCTGG/CGCTCA 2 -- ng515Minor allele frequency- C:0.09EA EU WA 1902
    --
    rs69992461,2
    A104220325(+) GAACTC/TCCCCA 2 -- ng510--------
    rs126781761,2
    C104220445(+) AGGCTC/TTGCTA 2 -- ng510--------
    --
    rs47346881,2
    A104221660(+) AGGCTC/TTGACT 2 -- ng510--------
    rs29355791,2
    A,C,F,H,O104226707(+) GACCCG/ATGTGA 2 -- int112Minor allele frequency- A:0.35EU EA WA NA 1052
    rs18740911,2
    A,C,F,H,O104228294(+) TATCAG/TGTTGT 2 -- int118Minor allele frequency- N:0.00EA NA EU WA 1402
    rs24540141,2
    A,C,F,H,O104224141(+) AGTTAC/TTATGG 2 -- int116Minor allele frequency- N:0.00EA NA EU WA 1470
    rs14942821,2
    A,C,F,H104246382(+) AGGAAC/TACACT 2 -- int111Minor allele frequency- T:0.03EU EA WA NA 978
    About this table

    HapMap Linkage Disequilibrium images for BAALC (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 606602

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/11 PubMed articles for BAALC gene (see all 11 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 79870 HGNC: 14333 AceView: BAALC Ensembl:ENSG00000164929 euGenes: HUgn79870
    ECgene: BAALC H-InvDB: BAALC
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for BAALC Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for BAALC:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for BAALC-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for BAALC Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for BAALC Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Recombinant Proteins
    (BAALC)
     Antibodies (BAALC)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for BAALC




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for BAALC

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