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Aliases & Descriptions for BAALC
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Descriptions brain and acute leukemia, cytoplasmic 2
Search outside databases for aliases for BAALC genePrevious GC identifers: GC08P103158 GC08P104221 GC08P103821 GC08P104109
Summaries for BAALC (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for BAALC : This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML).The gene is conserved among mammals and is not found in lower organisms. Tissues that express thisgene develop from the neuroectoderm. Multiple alternatively spliced transcript variants thatencode different proteins have been described for this gene; however, some of the transcriptvariants are found only in AML cell lines. [provided by RefSeq] UniProtKB/Swiss-Prot: BAALC_HUMAN, Q8WXS3 Function : May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A (Bysimilarity)
Genomic Location for BAALC
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the BAALC gene Entrez Gene cytogenetic band: 8q22.3 Ensembl cytogenetic band: 8q22.3 HGNC cytogenetic band: 8q22.3 BAALC Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08P104222:
(about GC identifiers )
Start:
104,222,097 bp from pter
End:
104,311,709 bp from pter
Size:
89,613 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000008.9 NT_008046.15 Proteins for BAALC
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: BAALC_HUMAN, Q8WXS3 (See
protein sequence )Recommended Name: Brain and acute leukemia cytoplasmic protein Size : 180 amino acids; 19224 Da
Subunit : Interacts with CAMK2A (By similarity)
Subcellular location : Cytoplasm. Membrane. Note=Postsynaptic lipid rafts (By similarity)
Secondary accessions : Q8WTP6 Q8WXS0 Q8WXS1 Q8WXS2 Q9HA93Alternative splicing : 6 isoforms : Q8WXS3-1 Q8WXS3-2 Q8WXS3-3 Q8WXS3-4 Q8WXS3-5 Q8WXS3-6
Post-translational modifications:
Palmitoylation and myristoylation target the protein to the lipid rafts (By similarity)1
REFSEQ proteins (2 alternative transcripts):
NP_001019543.1 NP_079088.1 ENSEMBL proteins: ENSP00000297574 ENSP00000331579 ENSP00000379202 ENSP00000302559 ENSP00000312457 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: BAALC 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for BAALC: Assays for BAALC:
Protein
Domains/ Families for BAALC(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q8WXS3 ProtoNet protein and cluster: Q8WXS3
Gene Function for BAALC
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
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RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_024812 Applied Biosystems Silencer ® siRNAs for BAALC Sigma-Aldrich siRNA for BAALC Sigma-Aldrich shRNA for BAALC Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001024372                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001024372                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001024372  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_024812 UniProtKB/Swiss-Prot: BAALC_HUMAN, Q8WXS3 Function : May play a synaptic role at the postsynaptic lipid rafts by interacting with CAMK2A (Bysimilarity)
Pathways & Interactions for BAALC
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5 Interacting proteins for BAALC (ENSP00000297574 3 Q8WXS3 2 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for BAALC (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for BAALC
Transcripts for BAALC(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
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shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_024812 Sigma-Aldrich siRNA for BAALC Sigma-Aldrich shRNA for BAALC Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001024372 NM_024812
REFSEQ mRNAs for BAALC gene (2 alternative transcripts): NM_001024372.1 NM_024812.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001024372 NM_024812
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001024372                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001024372                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001024372  
Additional cDNA sequence: AF371319.1 AF371323.1 AK022077.1 AK093819.1 AK310816.1 BC011517.1 BC014365.1 BC035038.2 CR597062.1 CR606691.1 CR607637.1 CR613048.1 CR615298.1
10 DOTS entries : DT.443046 DT.95092573 DT.91918803 DT.121479250 DT.100778235 DT.121479093 DT.426517 DT.95092568 DT.95092571 DT.95092599
24/227 AceView cDNA sequences (see all 227
):H89981 F02839 T33370 BI822259 CB054175 AW149362 Z45132 BC035038 F05239 AK093819 CR597062 R37607 F02877 AI356854 BM717611 BM927193 AI197813 AU120917 CR606691 T33369 CR613048 BQ447214 BM509802 F06570
highest scoring ESTs for BAALC :R60867 AA350529 AA351829 AA487577 AA488701 AA602607 AA663372 AA877472 AA903735 AA984630
Unigene Cluster for BAALC: Brain and acute leukemia, cytoplasmic Hs.533446 [show with all ESTs ] Unigene Representative Sequence: NM_024812 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for BAALC ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c SP1 :     -   -   -   -         SP2 :         -           SP3 :     -   -             SP4 :         -   -        
About this scheme ECgene alternative splicing isoforms for BAALC 5 Ensembl transcripts including schematic representations : ENST00000297574
ENST00000330955
ENST00000395861
ENST00000306391
ENST00000309982
Expression for BAALC
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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BAALC expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for BAALC 1 / 2 / 3
5 probe-sets matching BAALC gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TATGTATGAGSOURCE GeneReport for Unigene cluster: Hs.533446 UniProtKB/Swiss-Prot: BAALC_HUMAN, Q8WXS3 Tissue specificity : Expressed by neural and hematopoietic cells. Expression is found both in normalearly progenitor cells and in the most immature type of blasts in acute leukemia but not in maturehematopoietic cells. Isoform 2 and isoform 6 are expressed in the brain. Isoform 2 shows a lowexpression in neuroectoderm-derived tissues such as adrenal gland and no expression in bonemarrow, peripheral blood lymphocytes or lymph nodes, or in tumors or cancer cell lines ofnonneural tissue origin
Orthologs for BAALC
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for BAALC gene from 5/6 species (see all 6
)
About this table Species with no ortholog for BAALC ENSEMBL Gene Tree for BAALC Paralogs for BAALC (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for BAALC (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for BAALC (up to first 250kb)
Disorders & Mutations for BAALC
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 606602
Medical News for BAALC (Possibly Related Articles in
Doctor's Guide )
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Publications for BAALC (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/11 PubMed articles for BAALC gene (see all 11
): BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia. (PubMed id 11707601) 2, 3, 4 Tanner S.M.... de La Chapelle A. (2001) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) EVI1, BAALC and AME: prevalence of the secondary mutations in chronic and accelerated phases of chronic myeloid leukemia patients from eastern India. (PubMed id 18752846) 3 Kuila N....Chakraborty S. (2009) High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) study. (PubMed id 18378853) 3 Langer C....Bloomfield C.D. (2008) Up-regulation of BAALC gene may be an important alteration in AML-M2 patients with t(8;21) translocation. (PubMed id 18671757) 3 Qi X....Chen Z. (2008) Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcome. (PubMed id 17646667) 3 Baldus C.D....Hofmann W.K. (2007) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 3 Rual J.F....Vidal M. (2005) Baalc, a marker of mesoderm and muscle. (PubMed id 15749074) 3 Satoskar A.A....de la Chapelle A. (2005) Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal cytogenetics. (PubMed id 15604894) 3 Marcucci G....Bloomfield C.D. (2005)
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Genome Databases showing BAALC
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing BAALC
(According to HUGE )
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Specialized Databases showing BAALC (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for BAALC (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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