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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

B9D2 Gene

protein-coding   GIFtS: 53
GCID: GC19M041860

B9 Protein Domain 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
B9 Protein Domain 21 2     MKS102
MKSR22 3     B9 Domain-Containing Protein 22
MKS1-Related Protein 22 3     Involved In CIlia Stability-12
ICIS-12     

External Ids:    HGNC: 286361   Entrez Gene: 807762   Ensembl: ENSG000001238107   OMIM: 6119515   UniProtKB: Q9BPU93   

Export aliases for B9D2 gene to outside databases

Previous GC identifers: GC19M046553 GC19M038292


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for B9D2 Gene:
This gene encodes a B9 domain protein, which are exclusively found in ciliated organisms. The gene is upregulated
during mucociliary differentiation, and the encoded protein localizes to basal bodies and cilia. Disrupting
expression of this gene results in ciliogenesis defects. (provided by RefSeq, Oct 2009)

GeneCards Summary for B9D2 Gene: 
B9D2 (B9 protein domain 2) is a protein-coding gene. Diseases associated with B9D2 include b9d2-related meckel syndrome, and encephalocele, and among its related super-pathways are Mitotic Anaphase and Mitotic Prometaphase. GO annotations related to this gene include gamma-tubulin binding. An important paralog of this gene is B9D1.

UniProtKB/Swiss-Prot: B9D2_HUMAN, Q9BPU9
Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and
acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the B9D2 gene promoter:
         NF-1   NF-1/L   AML1a   RelA   Nkx2-5   Arnt   PPAR-gamma1   PPAR-gamma2   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidB9D2 promoter sequence
   Search SABiosciences Chromatin IP Primers for B9D2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat B9D2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

B9D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
B9D2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M041860:  view genomic region     (about GC identifiers)

Start:
41,860,322 bp from pter      End:
41,870,078 bp from pter
Size:
9,757 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: B9D2_HUMAN, Q9BPU9 (See protein sequence)
Recommended Name: B9 domain-containing protein 2  
Size: 175 amino acids; 19261 Da
Subunit: Part of the tectonic-like complex (also named B9 complex). Interacts with TUBG1 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Nucleus
(By similarity)

Explore the universe of human proteins at neXtProt for B9D2: NX_Q9BPU9

Explore proteomics data for B9D2 at MOPED 

B9D2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

B9D2 Protein Expression

REFSEQ proteins: NP_085055.2  
ENSEMBL proteins: 
 ENSP00000243578   ENSP00000469666  
Reactome Protein details: Q9BPU9
Human Recombinant Protein Products for B9D2: 
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Cloud-Clone Corp. Proteins for B9D2 

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005813centrosome IDA19208769
GO:0005829cytosol TAS--
GO:0005932microtubule basal body IDA19208769
GO:0016020membrane IEA--

B9D2 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR010796 B9_dom

Graphical View of Domain Structure for InterPro Entry Q9BPU9

ProtoNet protein and cluster: Q9BPU9

UniProtKB/Swiss-Prot: B9D2_HUMAN, Q9BPU9
Similarity: Belongs to the B9D family
Similarity: Contains 1 B9 domain


B9D2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: B9D2_HUMAN, Q9BPU9
Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and
acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI--
GO:0043015gamma-tubulin binding ISS--
     
B9D2 for ontologies           About GeneDecksing


Phenotypes:
     12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for B9d2):
 cellular  craniofacial  digestive/alimentary  growth/size  hematopoietic system 
 homeostasis/metabolism  immune system  limbs/digits/tail  liver/biliary system  mortality/aging 
 respiratory system  vision/eye 

B9D2 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for B9D2 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for B9D2 
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miRNA
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1 QIAGEN miScript miRNA Assays for microRNA that regulate B9D2:
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SwitchGear 3'UTR luciferase reporter plasmidB9D2 3' UTR sequence
Inhib. RNA
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for B9D2 About                                                                                                See pathways by source

SuperPathContained pathways About
1M Phase
Mitotic Anaphase0.94
M Phase0.88
Separation of Sister Chromatids0.94
Mitotic M-M/G1 phases0.88
Mitotic Metaphase and Anaphase0.94
2Resolution of Sister Chromatid Cohesion
Resolution of Sister Chromatid Cohesion0.93
Mitotic Prometaphase0.93
3Cell Cycle
Cell Cycle, Mitotic0.84
Cell Cycle0.84

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



5/9        Reactome Pathways for B9D2 (see all 9)
    Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Resolution of Sister Chromatid Cohesion
Mitotic Anaphase
Cell Cycle



B9D2 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for B9D2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/81 Interacting proteins for B9D2 (Q9BPU92, 3 ENSP000002435784) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
InteractantInteraction Details
GeneCardExternal ID(s)
INVSQ9Y2832, 3, ENSP000002624574MINT-8201267 MINT-8201190 MINT-8201172 MINT-8201254 I2D: score=1 STRING: ENSP00000262457
TTC30BQ8N4P22, 3, ENSP000003861814MINT-8201154 MINT-8201211 MINT-8201254 I2D: score=1 STRING: ENSP00000386181
NDE1ENSP000003458924STRING: ENSP00000345892
AHCTF1ENSP000003757054STRING: ENSP00000375705
AURKBENSP000003139504STRING: ENSP00000313950
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000278mitotic cell cycle TAS--
GO:0042384cilium assembly ISS--

B9D2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for B9D2

Search CenterWatch for drugs/clinical trials and news about B9D2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for B9D2 gene: 
NM_030578.3  

Unigene Cluster for B9D2:

B9 protein domain 2
Hs.567596  [show with all ESTs]
Unigene Representative Sequence: BQ900587
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000243578(uc002oqj.2) ENST00000594416 ENST00000601597
miRNA
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hsa-miR-3691-5p
SwitchGear 3'UTR luciferase reporter plasmidB9D2 3' UTR sequence
Inhib. RNA
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat B9D2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat B9D2

Additional mRNA sequence: 

BC004157.2 BC004444.1 

5 DOTS entries:

DT.308499  DT.446142  DT.101976621  DT.95268300  DT.99999889 

24/57 AceView cDNA sequences (see all 57):

BE794701 AW247300 BM833644 BQ052502 BI820173 AI972225 CB529481 BQ427546 
CA945159 BU609059 BM666419 BQ575046 BM020284 AI097326 AW518214 AI743007 
BC004444 BQ576019 CB128896 BQ009155 BI829218 BQ647466 BM797302 BM923726 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

B9D2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGAGGTGCTC
B9D2 Expression
About this image


See B9D2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for B9D2

SOURCE GeneReport for Unigene cluster: Hs.567596
    SABiosciences Custom PCR Arrays for B9D2
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B9D2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for B9D2 gene from 6/14 species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia B9d21 , 5 B9 protein domain 21, 5 88.19(n)1
96.57(a)1
  7 (13.97 cM)5
2329871  NM_172148.11  NP_742160.11 
 256811585 
lizard
(Anolis carolinensis)
Reptilia B9D26
Uncharacterized protein
76(a)
1 ↔ 1
LGf(3811580-3821850)
African clawed frog
(Xenopus laevis)
Amphibia Xl.181902 Xenopus laevis transcribed sequence with moderate similarity more 72.69(n)    BX847423.1 
zebrafish
(Danio rerio)
Actinopterygii b9d21 B9 protein domain 2 67.82(n)
75.86(a)
  436667  NM_001002394.1  NP_001002394.1 
fruit fly
(Drosophila melanogaster)
Insecta CG427306
--
44(a)
1 ↔ 1
2L(6127872-6130651)
worm
(Caenorhabditis elegans)
Secernentea mksr-21 Protein MKSR-2 47.62(n)
43.43(a)
  189676  NM_067785.1  NP_500186.1 


ENSEMBL Gene Tree for B9D2 (if available)
TreeFam Gene Tree for B9D2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for B9D2 gene
B9D12  
7 SIMAP similar genes for B9D2 using alignment to 2 protein entries:     B9D2_HUMAN (see all proteins):
FAM138A    FAM138B    FAM138C    FAM138F    FAM138D    PPT1
SIPA1L3

B9D2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/206 SNPs in B9D2 are shown (see all 206)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0366264
Meckel syndrome 10 (MKS10)4--see VAR_0366262 S R mis40--------
rs114663101,2
C,F,H--41861858(-) ttgctG/Attccc 1 -- int19Minor allele frequency- A:0.03NA EU NS 720
rs1889668431,2
--41861871(+) GCCAAG/TGCCCT 1 -- int10--------
rs1813245741,2
--41861968(+) GTGGGA/GAGACG 1 -- int10--------
rs1156145341,2
F--41862232(+) AAAGGG/ATAAGA 1 -- int11Minor allele frequency- A:0.02WA 118
rs116669331,2
C,F,A,H--41862253(+) aggatA/Gtattt 1 -- int123Minor allele frequency- G:0.45NS EA NA WA CSA 2352
rs133459811,2
C--41862463(+) TGAAAC/TCTCag 1 -- int10--------
rs1417839511,2
--41862547(+) AGTTCA/GAGACC 1 -- int10--------
rs1507428901,2
--41862562(+) TGACCA/GCCTTG 1 -- int10--------
rs1391191971,2
--41862636(+) CTGTAA/GTCCCA 1 -- int10--------

HapMap Linkage Disequilibrium report for B9D2 (41860322 - 41870078 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for B9D2:    About this table     
Variant IDTypeSubtypePubMed ID
esv1542493CNV Deletion17803354
esv2659362CNV Deletion23128226
nsv521311CNV Gain19592680


Human Gene Mutation Database (HGMD): B9D2
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing B9D2
DNA2.0 Custom Variant and Variant Library Synthesis for B9D2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 611951    OMIM disorders: --

UniProtKB/Swiss-Prot: B9D2_HUMAN, Q9BPU9
  • Meckel syndrome 10 (MKS10) [MIM:614175]: A disorder characterized by a combination of renal cysts and
    variably associated features including developmental anomalies of the central nervous system (typically
    encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 9 diseases for B9D2:    About MalaCards
    b9d2-related meckel syndrome    encephalocele    encephaloceles    meckel syndrome
    nephronophthisis    cystic kidney    polydactyly    gastric cancer
    hepatitis

    3 diseases from the University of Copenhagen DISEASES database for B9D2:
    Nephronophthisis     Cystic kidney     Polydactyly

    B9D2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): B9D2
    Human Genome Epidemiology (HuGE) Navigator: B9D2 (5 documents)

    Export disorders for B9D2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for B9D2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with B9D2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    2. Inflammation gene variants and susceptibility to albu minuria in the U.S. population: analysis in the Third National Health and Nutri tion Examination Survey (NHANES III), 1991-1994. (PubMed id 21054877)1, 4 Ned R.M....Dowling N.F. (2010)
    3. Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. (PubMed id 18936436)1, 4 Chang M.H....Khoury M.J. (2009)
    4. Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins. (PubMed id 19208769)1, 2 Bialas N.J.... Leroux M.R. (2009)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. Disruption of a ciliary B9 protein complex causes Meckel syndrome. (PubMed id 21763481)2 Dowdle W.E....Reiter J.F. (2011)
    7. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    8. The stumpy gene is required for mammalian ciliogenesi s. (PubMed id 18287022)1 Town T....Flavell R.A. (2008)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. Identification of ICIS-1, a new protein involved in cilia stability. (PubMed id 17127412)1 Ponsard C....Tournier F. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80776 HGNC: 28636 AceView: MGC4093 Ensembl:ENSG00000123810 euGenes: HUgn80776
    ECgene: B9D2 H-InvDB: B9D2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for B9D2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for B9D2 gene:
    Search GeneIP for patents involving B9D2

    GeneCards and IP:
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