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B9D2 Gene

protein-coding GIFtS: 41

GC19M046553

B9 protein domain 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ICIS-1 ^²
MGC4093 ^¹, ²

Descriptions
B9 domain-containing protein 2 ^²
B9 protein domain 2 ^²
involved in cIlia stability-1 ^²

External Ids
HGNC: 28636¹
Entrez Gene: 80776²
UniProtKB: Q9BPU9³
Ensembl: ENSG00000123810⁷

Search outside databases for aliases for B9D2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: B9D2_HUMAN, Q9BPU9

Function: May have a role in ciliogenesis (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

B9D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M046553: (about GC identifiers)

Start:	46,552,166 bp from pter
End:	46,561,877 bp from pter
Size:	9,712 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: B9D2_HUMAN, Q9BPU9 (See protein sequence)

Recommended Name: B9 domain-containing protein 2

Size: 175 amino acids; 19261 Da

Subunit: Interacts with TUBG1 (By similarity)

Subcellular location: Cell projection, cilium basal body (By similarity). Cell projection, cilium

axoneme (By similarity). Nucleus (By similarity)

REFSEQ proteins: NP_085055.2

ENSEMBL proteins:

ENSP00000243578

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: B9D2

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005929	cilium	IEA	--

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Antibodies for B9D2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for B9D2

Assays for B9D2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9BPU9

ProtoNet protein and cluster: Q9BPU9

UniProtKB/Swiss-Prot: B9D2_HUMAN, Q9BPU9

Similarity: Belongs to the B9D family

Similarity: Contains 1 B9 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (B9D2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_030578

Applied Biosystems Silencer® siRNAs for B9D2

Sigma-Aldrich siRNA for B9D2

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for B9D2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_030578
Myc/DDK tagged cDNA clone in CMV expression vector: NM_030578
untagged cDNA clone in CMV expression vector: NM_030578

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_030578

UniProtKB/Swiss-Prot: B9D2_HUMAN, Q9BPU9

Function: May have a role in ciliogenesis (By similarity)

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for B9d2):

hematopoietic system

immune system

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/77 Interacting proteins for B9D2 (ENSP00000243578³) via UniProtKB, MINT, and/or STRING (see all 77 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AHCTF1P	ENSP00000283201³	STRING (score=.899)
APITD1	ENSP00000317110³	STRING (score=.899)
AURKB	ENSP00000313950³	STRING (score=.899)
BGLAP	ENSP00000357259³	STRING (score=.899)
BIRC5	ENSP00000301633³	STRING (score=.899)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030030	cell projection organization	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for B9D2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (B9D2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_030578

Sigma-Aldrich siRNA for B9D2

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_030578

REFSEQ mRNAs for B9D2 gene:

NM_030578.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_030578

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_030578
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_030578
                                 untagged cDNA clone in CMV expression vector: NM_030578

Additional cDNA sequence:

BC004157.2 BC004444.1

5 DOTS entries:

DT.308499 DT.446142 DT.101976621 DT.95268300 DT.99999889

24/57 AceView cDNA sequences (see all 57 ):

BU609059 BQ427546 BQ575046 BQ052502 BM833644 AW247300 BE794701 CA945159

BI820173 CB529481 BM666419 AI972225 BQ576019 BI833871 BI829218 BQ009155

BC004157 AI743007 AI498322 CB241683 AI097326 BQ647466 BM713204 AA452277

Unigene Cluster for B9D2:

B9 protein domain 2

Hs.567596 [show with all ESTs]

Unigene Representative Sequence: BQ900587

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000243578

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

B9D2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for B9D2

¹ / ²

3 probe-sets matching B9D2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
76345_r_at²	U95-E	1	1.00	1.00	1.00	1.00	--	--	--	--	--
219766_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
219766_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks B9D2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGAGGTGCTC

SOURCE GeneReport for Unigene cluster: Hs.567596

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for B9D2 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	B9D2¹	--	B9 protein domain 2	88.57(n) 93.14(a)	476451 XM_533658.2 XP_533658.1
chimpanzee (Pan troglodytes)	B9D2¹	--	B9 protein domain 2	100(n) 100(a)	739216 XM_001140469.1 XP_001140469.1
cow (Bos taurus)	B9D2¹	--	B9 protein domain 2	90.29(n) 94.29(a)	616609 NM_001040593.1 NP_001035683.1
rat (Rattus norvegicus)	B9d2¹	--	B9 protein domain 2	87.77(n) 94.67(a)	308443 XM_218345.3 XP_218345.1
mouse (Mus musculus)	B9d2^{1, 5}	7⁵	B9 protein domain 2^{1, 5}	88(n)¹ 96(a)¹	232987¹ NM_172148.1¹ NP_742160.1¹ AK141500⁵ AK146227⁵ (see all 7)

About this table Species with no ortholog for B9D2

ENSEMBL Gene Tree for B9D2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for B9D2 gene

B9D1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/27 NCBI SNPs in B9D2 are shown (see all 27 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 23)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1982072^1,2	A,C,F,H,O	46556349(-)	`GCTTGT/AAAATA`	1	--	int¹		6		MN EU EA WA NA	667
	rs11083616^1,2	A,C,F,H	46557483(+)	`GCACCA/GAGTAC`	1	--	int¹		8		EU EA WA	838
--	rs11670143^1,2	A,C	46556811(+)	`ctggaA/Gaagct`	1	--	int¹		0	--	--	--	--
--	rs4803458^1,2	A,C	46557133(+)	`atggtA/Gaaact`	1	--	int¹		0	--	--	--	--
--	rs11673525^1,2	A,C	46559623(+)	`agttcA/Gagacc`	1	--	int¹		0	--	--	--	--
	rs11668109^1,2	A,C	46555617(+)	`CCTGGA/CCCCGG`	1	--	int¹		0	--	--	--	--
--	rs11083617^1,2	A,C	46558113(+)	`acgggG/Tgtctc`	1	--	int¹		0	--	--	--	--
--	rs11666933^1,2	A,C	46554093(+)	`aggatA/Gtattt`	1	--	int¹		0	--	--	--	--
--	rs11466310^1,2	C	46553698(-)	`ttgctG/Attccc`	1	--	int¹		3		NA EU	94
	rs34088631^1,2	--	46555661(+)	`GTGGCG/AAAGTG`	1	F/F	syn¹		1		NA	64

About this table

HapMap Linkage Disequilibrium images for B9D2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 611951

Human Genome Epidemiology Navigator: B9D2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

8 PubMed articles for B9D2 gene:

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. (PubMed id 18936436)³ Chang M.H....Khoury M.J. (2009)
Identification of ICIS-1, a new protein involved in cilia stability. (PubMed id 17127412)³ Ponsard C....Tournier F. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Transcriptome analysis of human gastric cancer. (PubMed id 16341674)³ Oh J.H....Kim N.S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)⁴ Grimwood J.... Lucas S.M. (2004)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)³ Bonaldo M.F....Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 80776	HGNC: 28636	AceView: MGC4093	Ensembl:ENSG00000123810	euGenes: HUgn80776
ECgene: B9D2	H-InvDB: B9D2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for B9D2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for B9D2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for B9D2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for B9D2		Browse antibodies at Sigma-Aldrich
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	Recombinant & Natural Proteins

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Search Tocris compounds for B9D2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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B9D2 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for B9D2

Summaries
for B9D2

Genomic Location
for B9D2

Proteins
for B9D2

Protein Domains/
Families
for B9D2

Gene Function
for B9D2

Pathways & Interactions
for B9D2

Drugs & Compounds
for B9D2

Transcripts
for B9D2

Expression
for B9D2

Orthologs
for B9D2

Paralogs
for B9D2

SNPs/Variants
for B9D2

Disorders & Mutations
for B9D2

Medical News
for B9D2

Publications
for B9D2

Search for B9D2

Genome Databases showing B9D2

Other Databases showing B9D2

Specialized Databases showing B9D2

Licensable Technologies
for B9D2

Services
for B9D2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

B9D2 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor B9D2

Summariesfor B9D2

Genomic Locationfor B9D2

Proteinsfor B9D2

Protein Domains/Familiesfor B9D2

Gene Functionfor B9D2

Pathways & Interactionsfor B9D2

Drugs & Compoundsfor B9D2

Transcriptsfor B9D2

Expression for B9D2

Orthologsfor B9D2

Paralogsfor B9D2

SNPs/Variantsfor B9D2

Disorders & Mutationsfor B9D2

Medical Newsfor B9D2

Publicationsfor B9D2

Search for B9D2

Genome Databases showing B9D2

Other Databases showing B9D2

Specialized Databases showing B9D2

Licensable Technologiesfor B9D2

Servicesfor B9D2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for B9D2

Summaries
for B9D2

Genomic Location
for B9D2

Proteins
for B9D2

Protein Domains/
Families
for B9D2

Gene Function
for B9D2

Pathways & Interactions
for B9D2

Drugs & Compounds
for B9D2

Transcripts
for B9D2

Expression
for B9D2

Orthologs
for B9D2

Paralogs
for B9D2

SNPs/Variants
for B9D2

Disorders & Mutations
for B9D2

Medical News
for B9D2

Publications
for B9D2

Licensable Technologies
for B9D2

Services
for B9D2