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B9D1 Gene

protein-coding GIFtS: 43

GC17M019188

B9 protein domain 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
B9 ^¹, ²
EPPB9 ^¹, ²

Descriptions
B9 protein ^²
B9 protein domain 1 ^²
endothelial precursor protein B9 ^²

External Ids
HGNC: 24123¹
Entrez Gene: 27077²
UniProtKB: Q9UPM9³
Ensembl: ENSG00000108641⁷

Search outside databases for aliases for B9D1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for B9D1:

The B9 protein function is not known. Identification of a conserved mouse homolog and

representation in the EST database indicates that this transcript does represent a gene. This gene

is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2

B9D1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M019188: (about GC identifiers)

Start:	19,187,076 bp from pter
End:	19,206,639 bp from pter
Size:	19,564 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: B9D1_HUMAN, Q9UPM9 (See protein sequence)

Recommended Name: B9 domain-containing protein 1

Size: 204 amino acids; 22775 Da

Secondary accessions: Q9BU22

Alternative splicing: 2 isoforms: Q9UPM9-1 Q9UPM9-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_056496.1

ENSEMBL proteins:

ENSP00000268841 ENSP00000378977 ENSP00000378978 ENSP00000261499

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (EPPB9)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for B9D1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for B9D1
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Monoclonal and Polyclonal Antibodies from Abnova (EPPB9)
	Novus Biologicals Antibody for B9D1

Assays for B9D1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UPM9

ProtoNet protein and cluster: Q9UPM9

UniProtKB/Swiss-Prot: B9D1_HUMAN, Q9UPM9

Similarity: Belongs to the B9D family

Similarity: Contains 1 B9 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (B9D1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015681

Applied Biosystems Silencer® siRNAs for B9D1

Sigma-Aldrich siRNA for B9D1

Sigma-Aldrich shRNA for B9D1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for B9D1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015681
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015681
untagged cDNA clones in CMV expression vector (see all 2): BC002944

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015681

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15231747

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for B9D1 (Q9UPM9¹) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
EXOSC10 Q01780¹ EBI-372535, EBI-358236
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for B9D1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (B9D1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015681

Sigma-Aldrich siRNA for B9D1

Sigma-Aldrich shRNA for B9D1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015681

REFSEQ mRNAs for B9D1 gene:

NM_015681.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015681

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015681
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015681
                                 untagged cDNA clones in CMV expression vector (see all 2): BC002944

Additional cDNA sequence:

AB030506.1 AK293815.1 AK297782.1 AK309320.1 BC002944.2 CR606056.1

10 DOTS entries:

DT.440966 DT.100752236 DT.86842265 DT.95266441 DT.92420107 DT.91967891 DT.97801922 DT.92010038

DT.95266450 DT.95266451

24/84 AceView cDNA sequences (see all 84 ):

CN479141 BM129815 BC002944 AA243643 BQ422055 AA256668 BM976857 CA776227

BU684397 BQ012937 CR606056 BE745789 CD676260 AW292166 CK819721 BM726709

BI825552 AI936091 NM_015681 BF025740 BX389591 BX389589 BX507706 AA431779

Unigene Cluster for B9D1:

B9 protein domain 1

Hs.462445 [show with all ESTs]

Unigene Representative Sequence: AK293815

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for B9D1 (see all 6 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9
SP1:																			-		-				-
SP2:																			-		-				-		-
SP3:																			-
SP4:																			-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for B9D1

4 Ensembl transcripts including schematic representations:

ENST00000268841 ENST00000395615 ENST00000395616 ENST00000261499

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

B9D1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for B9D1

¹ / ²

7 probe-sets matching B9D1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37511_at²	U95-A	1	1.00	1.00	1.00	1.00	--	--	--	--	--
210534_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
205662_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
210535_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
210534_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205662_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210535_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks B9D1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGGAAACTGG

SOURCE GeneReport for Unigene cluster: Hs.462445

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for B9D1 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	B9D1¹	--	B9 protein domain 1	91.5(n) 95.1(a)	479519 XM_536657.2 XP_536657.2
chimpanzee (Pan troglodytes)	B9D1¹	--	B9 protein domain 1	99.84(n) 100(a)	742196 XM_001153772.1 XP_001153772.1
cow (Bos taurus)	B9D1¹	--	B9 protein domain 1	89.54(n) 94.61(a)	505335 XM_581610.3 XP_581610.2
rat (Rattus norvegicus)	B9d1¹	--	B9 protein domain 1	87.58(n) 95.59(a)	287383 XM_213314.4 XP_213314.3
mouse (Mus musculus)	B9d1^{1, 5}	11⁵	B9 protein domain 1^{1, 5}	87.91(n)¹ 94.61(a)¹	27078¹ NM_013717.2¹ NP_038745.1¹ AB030483⁵ AK003038⁵ (see all 10)

About this table Species with no ortholog for B9D1

ENSEMBL Gene Tree for B9D1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for B9D1 gene

B9D2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/83 NCBI SNPs in B9D1 are shown (see all 83 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 53)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11204306^1,2	A,C,F,H	19207964(+)	`ATTCTA/GTCAGT`	1	--	ng3¹		4	EU EA WA	412
	rs8065263^1,2	C,F,H	19186745(+)	`GTTCTC/GTCCTT`	1	--	ng5¹		4	EU EA WA	420
	rs2296978^1,2	C,F,H	19206545(-)	`TTCTAG/AGGCAA`	1	--	ut5¹ ese³		8	EA NA EU WA	1804
	rs8072440^1,2	A,C,F,H	19199994(+)	`TCCAAG/AGAGtt`	1	--	int¹		7	EU EA WA NA	562
	rs3785773^1,2	A,C,F,H	19188772(-)	`CTCTGG/CCTCCC`	1	--	int¹		4	EU EA WA	418
	rs6587067^1,2	A,C,F,H	19198932(+)	`ctctcT/Cccctc`	1	--	int¹ trp³		7	EU EA WA NA	546
	rs4924987^1,2	A,C,F,H	19187668(+)	`GGGATG/AGGGGT`	1	--	int¹		4	EU EA WA	416
--	rs6587071^1,2	A,C,F,H	19205104(+)	`attctC/Acatta`	1	--	int¹		4	EU EA WA	418
	rs4924782^1,2	A,C,F,H	19190253(+)	`GCATTA/CTCGGC`	1	--	int¹		4	EU EA WA	412
--	rs8066640^1,2	A,C,F,H	19196061(+)	`tgttgA/Ggatta`	1	--	int¹		4	EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for B9D1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for B9D1 gene:

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
A protein interaction framework for human mRNA degradation. (PubMed id 15231747)³ Lehner B. and Sanderson C.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 27077	HGNC: 24123	AceView: EPPB9	Ensembl:ENSG00000108641	euGenes: HUgn27077
ECgene: B9D1	H-InvDB: B9D1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for B9D1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for B9D1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for B9D1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for B9D1		Antibodies for B9D1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for B9D1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EPPB9)
	Antibodies (EPPB9)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Search for Recombinant Proteins
	Search for Antibodies

Search OriGene for B9D1

Search Tocris compounds for B9D1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for B9D1

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B9D1 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for B9D1

Summaries
for B9D1

Genomic Location
for B9D1

Proteins
for B9D1

Protein Domains/
Families
for B9D1

Gene Function
for B9D1

Pathways & Interactions
for B9D1

Drugs & Compounds
for B9D1

Transcripts
for B9D1

Expression
for B9D1

Orthologs
for B9D1

Paralogs
for B9D1

SNPs/Variants
for B9D1

Disorders & Mutations
for B9D1

Medical News
for B9D1

Publications
for B9D1

Search for B9D1

Genome Databases showing B9D1

Other Databases showing B9D1

Specialized Databases showing B9D1

Licensable Technologies
for B9D1

Services
for B9D1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

B9D1 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor B9D1

Summariesfor B9D1

Genomic Locationfor B9D1

Proteinsfor B9D1

Protein Domains/Familiesfor B9D1

Gene Functionfor B9D1

Pathways & Interactionsfor B9D1

Drugs & Compoundsfor B9D1

Transcriptsfor B9D1

Expression for B9D1

Orthologsfor B9D1

Paralogsfor B9D1

SNPs/Variantsfor B9D1

Disorders & Mutationsfor B9D1

Medical Newsfor B9D1

Publicationsfor B9D1

Search for B9D1

Genome Databases showing B9D1

Other Databases showing B9D1

Specialized Databases showing B9D1

Licensable Technologiesfor B9D1

Servicesfor B9D1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for B9D1

Summaries
for B9D1

Genomic Location
for B9D1

Proteins
for B9D1

Protein Domains/
Families
for B9D1

Gene Function
for B9D1

Pathways & Interactions
for B9D1

Drugs & Compounds
for B9D1

Transcripts
for B9D1

Expression
for B9D1

Orthologs
for B9D1

Paralogs
for B9D1

SNPs/Variants
for B9D1

Disorders & Mutations
for B9D1

Medical News
for B9D1

Publications
for B9D1

Licensable Technologies
for B9D1

Services
for B9D1