Aliases for B4GALT6 Gene
- UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 6 2 3
- UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,4-Galactosyltransferase 6 3 4
- UDP-Gal:Glucosylceramide Beta-1,4-Galactosyltransferase 2 3
- UDP-Gal:Beta-GlcNAc Beta-1,4-Galactosyltransferase 6 3 4
- Beta-1,4-GalTase 6 3 4
- Beta4Gal-T6 3 4
External Ids for B4GALT6 Gene
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for B4GALT6 Gene
B4GALT6 (UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 6) is a Protein Coding gene. Diseases associated with B4GALT6 include prostate carcinoma in situ. Among its related pathways are Disease and Sphingolipid metabolism. GO annotations related to this gene include galactosyltransferase activity and UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. An important paralog of this gene is B4GALT7.
UniProtKB/Swiss-Prot for B4GALT6 Gene
Required for the biosynthesis of glycosphingolipids.