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Aliases & Descriptions for B4GALT5
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| B4Gal-T5 2 | | BETA4-GALT-IV 2 | | Beta4Gal-T5 3 | | EC 2.4.1.- 3 | | MGC138470 2 | | OTTHUMP00000031806 2 | | b4Gal-T5 3 | | beta4Gal-T5 2 | | beta4GalT-V 1, 2 | | gt-V 2 |
| | | Descriptions |
|---|
| Beta-1,4-GalT II 3 | | Beta-1,4-GalTase 5 3 | | UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5 3 | | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 5 2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 2 | UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 2 | UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5 3 | | beta-1,4-GalT IV 2 | | beta-1.4-galactosyltransferase V 2 | | beta4-GalT IV 2 |
|
| | Search outside databases for aliases for B4GALT5 genePrevious GC identifers: GC20M047977 GC20M048887 GC20M048935 GC20M048936 |
Summaries for B4GALT5(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for B4GALT5: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. [provided by RefSeq] UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286Function: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipidsGene Wiki entry for B4GALT5 |
Genomic Location for B4GALT5
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the B4GALT5 gene 
Entrez Gene cytogenetic band: 20q13.1-q13.2 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13.1-q13.2B4GALT5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M047682:
(about GC identifiers)
Start:
|
47,682,889 bp from pter |
End:
|
47,763,745 bp from pter |
Size:
|
80,857 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000020.9 NT_011362.9
| Proteins for B4GALT5
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286 (See
protein sequence)Recommended Name: Beta-1,4-galactosyltransferase 5 Size: 388 amino acids; 45119 Da
Cofactor: Manganese (By similarity)
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack
Secondary accessions: Q2M394 Q9UJQ8REFSEQ proteins: NP_004767.1
ENSEMBL proteins: ENSP00000360776
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for B4GALT5: Assays for B4GALT5: | Protein
Domains/ Families for B4GALT5(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O43286
ProtoNet protein and cluster: O43286 1 Blocks protein family: IPB003859 Metazoa galactosyltransferase
UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286Similarity: Belongs to the glycosyltransferase 7 family | Gene Function for B4GALT5
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004776
Applied Biosystems Silencer® siRNAs for B4GALT5
Sigma-Aldrich siRNA for B4GALT5  Sigma-Aldrich shRNA for B4GALT5  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004776                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004776                                  untagged cDNA clone in CMV expression vector: NM_004776 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004776
UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286Function: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipidsEnzyme Number (IUBMB): EC 2.4.1.- Genatlas biochemistry entry for B4GALT5:UDP galactose5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for B4galt5):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for B4GALT5
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for B4GALT5 (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286Pathway: Protein modification; protein glycosylation 5/7 Interacting proteins for B4GALT5 (ENSP000003607763) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
IEA | -- | About this table
|
Drugs & Compounds for B4GALT5(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for B4GALT5
|
Transcripts for B4GALT5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004776
Sigma-Aldrich siRNA for B4GALT5  Sigma-Aldrich shRNA for B4GALT5  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004776 REFSEQ mRNAs for B4GALT5 gene: NM_004776.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004776               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004776                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004776                                  untagged cDNA clone in CMV expression vector: NM_004776  Additional cDNA sequence: AB004550.1 AF038663.1 AF289556.1 AK054803.1 AK056333.1 BC074821.2 BC074873.2 BC104987.1 BC112265.1 5 DOTS entries: DT.451617 DT.87017400 DT.95134284 DT.87017870 DT.91719572 24/335 AceView cDNA sequences (see all 335
):BM969496 AA243839 AI818828 BX509324 AI093151 AA292088 CA415351 BM843323 AW043860 BX499835 AA223526 CD366019 AI924160 AA975469 AA716159 CD674125 AI085327 AI078366 CD674479 BM989877 AI239686 BE858968 BG057973 AI245395
highest scoring ESTs for B4GALT5:AB004550 AA243575 AA648382 AA736578 AA836169 AA918180 AF038663 AI017532 AI088794 AI095142 Unigene Cluster for B4GALT5: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 Hs.370487 [show with all ESTs]Unigene Representative Sequence: NM_004776
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000371711
|
Expression for B4GALT5
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| B4GALT5 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for B4GALT5
1 / 2 / 3 6 probe-sets matching B4GALT5 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGTTTGTACA
SOURCE GeneReport for Unigene cluster: Hs.370487
Expression variation in blood from EXPOLDB for B4GALT5 UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286Tissue specificity: Ubiquitously expressed |
Orthologs for B4GALT5
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for B4GALT5 gene from 5/10 species (see all 10
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
B4GALT51 |
-- |
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, more |
92.1(n) 96.86(a) |
485920 XM_543044.2 XP_543044.2 |
chimpanzee (Pan troglodytes) |
B4GALT51 |
-- |
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, more |
99.48(n) 99.74(a) |
458324 XM_001167173.1 XP_001167173.1 |
cow (Bos taurus) |
B4GALT51 |
-- |
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, more |
89.81(n) 96(a) |
282407 XM_586129.3 XP_586129.3 |
rat (Rattus norvegicus) |
B4galt51 |
-- |
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, more |
80.23(n) 82.15(a) |
362275 XM_342584.3 XP_342585.3 |
mouse (Mus musculus) |
B4galt51, 5 |
25
|
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, more1, 5 |
87.46(n)1 95.1(a)1 |
563361 NM_019835.21 NP_062809.21 AA0087725 AB0047865 (see all 25) |
About this table Species with no ortholog for B4GALT5
ENSEMBL Gene Tree for B4GALT5 | Paralogs for B4GALT5(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for B4GALT5 gene
- B4GALT72 B4GALT62
|
SNPs/Variants for B4GALT5(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for B4GALT5 (up to first 250kb)
|
Disorders & Mutations for B4GALT5
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604016
|
Medical News for B4GALT5(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for B4GALT5 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for B4GALT5 gene (see all 16
):- The expanding beta 4-galactosyltransferase gene family: messages from the databanks. (PubMed id 9597550)2, 3, 4 Lo N.W....Shaper N.L. (1998)
- Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase. (PubMed id 9435216)2, 3, 4 Sato T....Van Die I. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)3, 4 Deloukas P....Rogers J. (2001)
- Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PubMed id 10580128)3, 4 Amado M.... Clausen H. (1999)
- Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells. (PubMed id 17656364)3 Sato T. and Furukawa K. (2007)
- Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans. (PubMed id 17690104)3 Kitayama K....Akama T.O. (2007)
- Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma. (PubMed id 16461357)3 Jiang J....Gu J. (2006)
- Transcriptional regulation of the human beta-1,4- galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1. (PubMed id 15263012)3 Sato T. and Furukawa K. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
|
Search for B4GALT5
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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|
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Query String |
|
PubMed
OMIM
NCBI Bookshelf
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Genome Databases showing B4GALT5
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing B4GALT5
(According to HUGE)
About This Section
| -- |
Specialized Databases showing B4GALT5(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/ | | Functional Glycomics Gateway - GTase | http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_440 |
|
| | | About This Section
| --
| Services for B4GALT5(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for B4GALT5:

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Incremental update: 13 Oct 2009
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