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B4GALT5 Gene

protein-coding   GIFtS: 60
GCID: GC20M048249

UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide...

  See B4GALT5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 51 2     Beta-1,4-GalT IV2
Beta4-GalT IV1 2     Beta-1.4-Galactosyltransferase V2
Beta-1,4-GalT II2 3     beta4Gal-T52
Beta-1,4-GalTase 52 3     beta4GalT-V2
UDP-Gal:Beta-GlcNAc Beta-1,4-Galactosyltransferase 52 3     gt-V2
UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,4-Galactosyltransferase 52 3     UDP-Gal:BetaGlcNAc Beta 1,4-Galactosyltransferase, Polypeptide 52
B4Gal-T52     Beta4Gal-T53
BETA4-GALT-IV2     EC 2.4.1.-3
Beta-1,4-Galactosyltransferase 52     b4Gal-T53

External Ids:    HGNC: 9281   Entrez Gene: 93342   Ensembl: ENSG000001584707   OMIM: 6040165   UniProtKB: O432863   

Export aliases for B4GALT5 gene to outside databases

Previous GC identifers: GC20M047977 GC20M048887 GC20M048935 GC20M048936 GC20M047682 GC20M044999


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for B4GALT5 Gene:
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound
glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer
galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct
function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane
proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and
which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form
four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The
function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was
renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. (provided by RefSeq, Jul 2008)

GeneCards Summary for B4GALT5 Gene:
B4GALT5 (UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5) is a protein-coding gene. Diseases associated with B4GALT5 include nasopharynx carcinoma. GO annotations related to this gene include galactosyltransferase activity. An important paralog of this gene is B4GALT2.

UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286
Function: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as
the carbohydrate moieties of glycolipids

Gene Wiki entry for B4GALT5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the B4GALT5 gene promoter:
         HOXA9B   HOXA9   Spz1   Pax-5   Egr-1   AP-4   Meis-1b   HEN1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidB4GALT5 promoter sequence
   Search Chromatin IP Primers for B4GALT5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat B4GALT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1-q13.2   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.1-q13.2

B4GALT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
B4GALT5 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M048249:  view genomic region     (about GC identifiers)

Start:
48,249,482 bp from pter      End:
48,330,421 bp from pter
Size:
80,940 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286 (See protein sequence)
Recommended Name: Beta-1,4-galactosyltransferase 5  
Size: 388 amino acids; 45119 Da
Cofactor: Manganese (By similarity)
Secondary accessions: E1P625 Q2M394 Q9UJQ8

Explore the universe of human proteins at neXtProt for B4GALT5: NX_O43286

Explore proteomics data for B4GALT5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr59, Asn77, Asn81, Asn90, Asn111, Asn128, Asn364, Asn373
  • Modification sites at PhosphoSitePlus

  • See B4GALT5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004767.1  
    ENSEMBL proteins: 
     ENSP00000360776  
    Reactome Protein details: O43286

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    B4GT: Beta 4-glycosyltransferases

    3 InterPro protein domains:
     IPR003859 Galactosyl_T
     IPR027995 Glyco_transf_7N
     IPR027791 Galactosyl_T_C

    Graphical View of Domain Structure for InterPro Entry O43286

    ProtoNet protein and cluster: O43286

    1 Blocks protein domain: IPB003859 Metazoa galactosyltransferase

    UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286
    Similarity: Belongs to the glycosyltransferase 7 family


    Find genes that share domains with B4GALT5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B4GT5_HUMAN, O43286
    Function: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as
    the carbohydrate moieties of glycolipids

         Genatlas biochemistry entry for B4GALT5:
    UDP galactose

         Enzyme Number (IUBMB): EC 2.4.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008378galactosyltransferase activity TAS9597550
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with B4GALT5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for B4GALT5:
     Decreased viability of wild-ty  Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for B4galt5):
     behavior/neurological  embryogenesis  growth/size/body  homeostasis/metabolism  mortality/aging 

    Find genes that share phenotypes with B4GALT5           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for B4GALT5
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    miRTarBase miRNAs that target B4GALT5:
    hsa-mir-503-5p (MIRT041131), hsa-mir-124-3p (MIRT023032), hsa-mir-29b-3p (MIRT048365), hsa-mir-335-5p (MIRT018798)

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    hsa-miR-30d hsa-miR-502-3p hsa-miR-30a hsa-miR-376a* hsa-miR-3148 hsa-miR-130b hsa-miR-2113 hsa-miR-3688-3p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    B4GT5_HUMAN, O43286: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans
    cisternae of Golgi stack
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    mitochondrion2
    cytosol1
    extracellular1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--

    Find genes that share ontologies with B4GALT5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for B4GALT5 About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.47
    Mucin type O-Glycan biosynthesis0.47
    2MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Metabolism of proteins0.30
    Post-translational protein modification0.43
    N-glycan antennae elongation in the medial/trans-Golgi0.00
    Transport to the Golgi and subsequent modification0.40
    N-Glycan antennae elongation0.00
    4Keratan sulfate/keratin metabolism
    Keratan sulfate/keratin metabolism0.85
    Keratan sulfate biosynthesis0.85
    5Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with B4GALT5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for B4GALT5
        Sperm Motility

    3 Reactome Pathways for B4GALT5
        O-linked glycosylation of mucins
    N-Glycan antennae elongation
    Keratan sulfate biosynthesis


    1 Kegg Pathway  (Kegg details for B4GALT5):
        Mucin type O-Glycan biosynthesis

    UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286
    Pathway: Protein modification; protein glycosylation

        Pathway & Disease-focused RT2 Profiler PCR Array including B4GALT5: 

              Glycosylation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for B4GALT5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for B4GALT5 (ENSP000003607764) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GCNT1ENSP000003659204STRING: ENSP00000365920
    MUC1ENSP000003389834STRING: ENSP00000338983
    MUC12ENSP000003687554STRING: ENSP00000368755
    MUC13ENSP000003122354STRING: ENSP00000312235
    MUC15ENSP000004167534STRING: ENSP00000416753
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0016266O-glycan processing TAS--
    GO:0018146keratan sulfate biosynthetic process TAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--

    Find genes that share ontologies with B4GALT5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for B4GALT5 (B4GT5)

    1 HMDB Compound for B4GALT5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Manganesemanganese 7439-96-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for B4GALT5 gene: 
    NM_004776.3  

    Unigene Cluster for B4GALT5:

    UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
    Hs.370487  [show with all ESTs]
    Unigene Representative Sequence: NM_004776
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371711(uc002xuu.4)
    miRNA
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    Additional mRNA sequence: 

    AB004550.1 AF038663.1 AF289556.1 AK054803.1 AK056333.1 BC074821.2 BC074873.2 BC104987.1 
    BC112265.1 

    5 DOTS entries:

    DT.451617  DT.87017400  DT.95134284  DT.87017870  DT.91719572 

    Selected AceView cDNA sequences (see all 335):

    AI360309 BU727476 AA243839 CD366019 AW674690 BX509324 AI219311 AI494533 
    AW043860 CD674125 BM806543 AA292088 AA345058 CD674479 AA836169 AA975469 
    BM856675 BC074873 BX505289 BM843323 BM989877 AW503897 AI239686 AI923994 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    B4GALT5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTGTACA
    B4GALT5 Expression
    About this image


    B4GALT5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Eye (Sensory Organs)
             Retina
     
     Neural Tube (Nervous System)
             Metencephalon
    B4GALT5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    B4GALT5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370487

    UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286
    Tissue specificity: Ubiquitously expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including B4GALT5: 
              Glycosylation in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B4GALT5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for B4GALT5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia B4galt51 , 5 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, more1, 5 86.82(n)1
    94.71(a)1
      2 (87.22 cM)5
    563361  NM_019835.21  NP_062809.21 
     1672984445 
    chicken
    (Gallus gallus)
    Aves B4GALT51 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, more 82.82(n)
    91.36(a)
      419358  XM_417519.4  XP_417519.4 
    lizard
    (Anolis carolinensis)
    Reptilia B4GALT56
    UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase...
    88(a)
    1 ↔ 1
    4(146953371-147030925)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL888833.22   -- 78.96(n)    AL888833.2 
    zebrafish
    (Danio rerio)
    Actinopterygii b4galt51 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, more 66.85(n)
    71.19(a)
      724080  NM_001045332.1  NP_001038797.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG145173 UDP-galactose-glucosylceramide
    beta-1,4-galactosyltransferase
    38(a)
    (best of 2)
      98F5   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y73E7A.73
    W02B12.111
    W02B12.111 41(a)
    (best of 2)3
    46.86(n)1
    38.36(a)1
      I(1621527-1626606)3
    1747541  NM_064048.51  NP_496449.11 


    ENSEMBL Gene Tree for B4GALT5 (if available)
    TreeFam Gene Tree for B4GALT5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for B4GALT5 gene
    B4GALT22  B4GALT12  B4GALT42  B4GALT72  B4GALT62  B4GALT32  
    5 SIMAP similar genes for B4GALT5 using alignment to 1 protein entry:     B4GT5_HUMAN:
    B4GALT6    B4GALT1    B4GALT4    B4GALT3    B4GALT2

    Find genes that share paralogs with B4GALT5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for B4GALT5 (see all 1763)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739105781,2
    C,F--48249090(+) GATGAC/TAATCT 1 -- int12Minor allele frequency- T:0.10WA 120
    rs1398227961,2
    --48249140(+) GAGAAA/CCTTCT 1 -- int10--------
    rs1453706571,2
    --48249259(+) CCAAGC/TGTGGG 1 -- int10--------
    rs1167264331,2
    C,F--48249307(+) CACTGC/TGTAGC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1477370761,2
    --48249308(+) ACTGCA/GTAGCT 1 -- int10--------
    rs757925201,2
    C--48249311(+) GCGTAG/TCTTTT 1 -- int10--------
    rs61228001,2
    C--48249382(+) CTCAGC/ATGAGC 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1891501371,2
    --48249404(+) GAACTA/CCTGTA 1 -- int10--------
    rs1810874461,2
    --48249407(+) CTCCTG/TTAGGA 1 -- int10--------
    rs1865911951,2
    --48249639(+) TACCCC/TTGGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for B4GALT5 (48249482 - 48330421 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for B4GALT5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819562CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing B4GALT5
    DNA2.0 Custom Variant and Variant Library Synthesis for B4GALT5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604016    OMIM disorders: --

    1 disease for B4GALT5:    
    About MalaCards
    nasopharynx carcinoma

    3 diseases from the University of Copenhagen DISEASES database for B4GALT5:
    Lung cancer     Cervical cancer     Nasopharynx carcinoma

    Find genes that share disorders with B4GALT5           About GenesLikeMe


    Export disorders for B4GALT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for B4GALT5 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with B4GALT5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. (PubMed id 9597550)1, 2, 3 Lo N.-W.... Shaper N.L. (Glycobiology 1998)
    2. Molecular cloning of a human cDNA encoding beta-1,4- galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase. (PubMed id 9435216)1, 2, 3 Sato T.... van Die I. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PubMed id 10580128)1, 2 Amado M.... Clausen H. (Biochim. Biophys. Acta 1999)
    6. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PubMed id 23362303)1 Wu J.H....Mozaffarian D. (Circ Cardiovasc Genet 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1. (PubMed id 23744354)1 Zhou H....Jia L. (amp 2013)
    9. [Regulation of human I^-1,4-galactosyltransferase V gene expression in cancer cells]. (PubMed id 22687727)1 Sato T. and Furukawa K. (Yakugaku Zasshi 2012)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9334 HGNC: 928 AceView: B4GALT5 Ensembl:ENSG00000158470 euGenes: HUgn9334
    ECgene: B4GALT5 Kegg: 9334 H-InvDB: B4GALT5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for B4GALT5 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B4GALT5
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_440

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for B4GALT5 gene:
    Search GeneIP for patents involving B4GALT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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