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Aliases for B4GALT5 Gene

Aliases for B4GALT5 Gene

  • Beta-1,4-Galactosyltransferase 5 2 3
  • UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 5 2 3 5
  • UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,4-Galactosyltransferase 5 3 4
  • UDP-Gal:Beta-GlcNAc Beta-1,4-Galactosyltransferase 5 3 4
  • Beta-1,4-GalTase 5 3 4
  • Beta-1,4-GalT II 3 4
  • Beta4-GalT IV 2 3
  • Beta4Gal-T5 3 4
  • B4Gal-T5 3 4
  • UDP-Gal:BetaGlcNAc Beta 1,4-Galactosyltransferase, Polypeptide 5 3
  • Beta-1.4-Galactosyltransferase V 3
  • Beta-1,4-GalT IV 3
  • BETA4-GALT-IV 3
  • Beta4GalT-V 3
  • EC 2.4.1.- 4
  • Gt-V 3

External Ids for B4GALT5 Gene

Previous GeneCards Identifiers for B4GALT5 Gene

  • GC20M047977
  • GC20M048887
  • GC20M048935
  • GC20M048936
  • GC20M047682
  • GC20M048249
  • GC20M044999

Summaries for B4GALT5 Gene

Entrez Gene Summary for B4GALT5 Gene

  • This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. [provided by RefSeq, Jul 2008]

GeneCards Summary for B4GALT5 Gene

B4GALT5 (Beta-1,4-Galactosyltransferase 5) is a Protein Coding gene. Diseases associated with B4GALT5 include pharynx cancer and nasopharynx carcinoma. Among its related pathways are Mucin type O-Glycan biosynthesis and Sweet Taste Signaling. GO annotations related to this gene include galactosyltransferase activity. An important paralog of this gene is B4GALT7.

UniProtKB/Swiss-Prot for B4GALT5 Gene

  • Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Gene Wiki entry for B4GALT5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B4GALT5 Gene

Genomics for B4GALT5 Gene

Regulatory Elements for B4GALT5 Gene

Enhancers for B4GALT5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around B4GALT5 on UCSC Golden Path with GeneCards custom track

Promoters for B4GALT5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around B4GALT5 on UCSC Golden Path with GeneCards custom track

Genomic Location for B4GALT5 Gene

Chromosome:
20
Start:
49,632,945 bp from pter
End:
49,713,884 bp from pter
Size:
80,940 bases
Orientation:
Minus strand

Genomic View for B4GALT5 Gene

Genes around B4GALT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B4GALT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B4GALT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B4GALT5 Gene

Proteins for B4GALT5 Gene

  • Protein details for B4GALT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43286-B4GT5_HUMAN
    Recommended name:
    Beta-1,4-galactosyltransferase 5
    Protein Accession:
    O43286
    Secondary Accessions:
    • E1P625
    • Q2M394
    • Q9UJQ8

    Protein attributes for B4GALT5 Gene

    Size:
    388 amino acids
    Molecular mass:
    45119 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for B4GALT5 Gene

Proteomics data for B4GALT5 Gene at MOPED

Post-translational modifications for B4GALT5 Gene

  • Glycosylation at Thr 59, Asn 77, Asn 81, Asn 90, Asn 111, Asn 128, Asn 364, and Asn 373
  • Modification sites at PhosphoSitePlus

Other Protein References for B4GALT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for B4GALT5 Gene

Domains & Families for B4GALT5 Gene

Gene Families for B4GALT5 Gene

Suggested Antigen Peptide Sequences for B4GALT5 Gene

Graphical View of Domain Structure for InterPro Entry

O43286

UniProtKB/Swiss-Prot:

B4GT5_HUMAN :
  • Belongs to the glycosyltransferase 7 family.
Family:
  • Belongs to the glycosyltransferase 7 family.
genes like me logo Genes that share domains with B4GALT5: view

Function for B4GALT5 Gene

Molecular function for B4GALT5 Gene

GENATLAS Biochemistry:
UDP galactose
UniProtKB/Swiss-Prot Function:
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Enzyme Numbers (IUBMB) for B4GALT5 Gene

genes like me logo Genes that share phenotypes with B4GALT5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for B4GALT5

miRNA for B4GALT5 Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for B4GALT5 Gene

Localization for B4GALT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B4GALT5 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B4GALT5 Gene COMPARTMENTS Subcellular localization image for B4GALT5 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
mitochondrion 2
plasma membrane 2
cytosol 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for B4GALT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with B4GALT5: view

Pathways & Interactions for B4GALT5 Gene

genes like me logo Genes that share pathways with B4GALT5: view

Pathways by source for B4GALT5 Gene

UniProtKB/Swiss-Prot O43286-B4GT5_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for B4GALT5 Gene

Gene Ontology (GO) - Biological Process for B4GALT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0016266 O-glycan processing TAS --
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0042339 keratan sulfate metabolic process TAS --
genes like me logo Genes that share ontologies with B4GALT5: view

No data available for SIGNOR curated interactions for B4GALT5 Gene

Drugs & Compounds for B4GALT5 Gene

(1) Drugs for B4GALT5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Pharma 32
genes like me logo Genes that share compounds with B4GALT5: view

Transcripts for B4GALT5 Gene

mRNA/cDNA for B4GALT5 Gene

Unigene Clusters for B4GALT5 Gene

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B4GALT5 Gene

No ASD Table

Relevant External Links for B4GALT5 Gene

GeneLoc Exon Structure for
B4GALT5
ECgene alternative splicing isoforms for
B4GALT5

Expression for B4GALT5 Gene

mRNA expression in normal human tissues for B4GALT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B4GALT5 Gene

This gene is overexpressed in Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for B4GALT5 Gene

This gene is overexpressed in Milk (24.6) and Urine (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for B4GALT5 Gene



SOURCE GeneReport for Unigene cluster for B4GALT5 Gene Hs.370487

mRNA Expression by UniProt/SwissProt for B4GALT5 Gene

O43286-B4GT5_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with B4GALT5: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for B4GALT5 Gene

Orthologs for B4GALT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for B4GALT5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia B4GALT5 35
  • 89.73 (n)
  • 96.22 (a)
B4GALT5 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia B4GALT5 35
  • 92 (n)
  • 96.57 (a)
B4GALT5 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B4galt5 35
  • 86.82 (n)
  • 94.71 (a)
B4galt5 16
B4galt5 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia B4GALT5 35
  • 99.48 (n)
  • 99.74 (a)
B4GALT5 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia B4GALT5 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B4GALT5 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves B4GALT5 35
  • 82.82 (n)
  • 91.36 (a)
B4GALT5 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia B4GALT5 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia b4galt6 35
  • 75.42 (n)
  • 83.24 (a)
zebrafish
(Danio rerio)
Actinopterygii b4galt5 35
  • 66.85 (n)
  • 71.19 (a)
b4galt5 36
  • 70 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH13356 37
  • 38 (a)
CG14517 37
  • 38 (a)
beta4GalT7 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W02B12.11 37
  • 36 (a)
Y73E7A.7 37
  • 41 (a)
W02B12.11 35
  • 46.86 (n)
  • 38.36 (a)
sqv-3 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for B4GALT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for B4GALT5 Gene

ENSEMBL:
Gene Tree for B4GALT5 (if available)
TreeFam:
Gene Tree for B4GALT5 (if available)

Paralogs for B4GALT5 Gene

Paralogs for B4GALT5 Gene

(5) SIMAP similar genes for B4GALT5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B4GALT5: view

Variants for B4GALT5 Gene

Sequence variations from dbSNP and Humsavar for B4GALT5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2273086 - 49,656,637(+) AGCAC(C/T)GATTG reference, missense
rs35195217 - 49,636,368(-) CCTTG(G/T)ATAAA reference, missense
rs235035 - 49,636,377(+) GGCGT(C/G/T)GTATG reference, missense
rs421801 -- 49,640,612(+) ATTGC(C/T)TCTTG reference, synonymous-codon
rs453071 -- 49,640,268(+) CGTAA(C/T)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for B4GALT5 Gene

Variant ID Type Subtype PubMed ID
nsv819562 CNV Loss 19587683

Variation tolerance for B4GALT5 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.15; 69.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B4GALT5 Gene

HapMap Linkage Disequilibrium report
B4GALT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B4GALT5 Gene

Disorders for B4GALT5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for B4GALT5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pharynx cancer
  • pharyngeal cancer
nasopharynx carcinoma
  • nasopharyngeal carcinoma
vulvitis
retroperitoneal sarcoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for B4GALT5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
B4GALT5
genes like me logo Genes that share disorders with B4GALT5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for B4GALT5 Gene

Publications for B4GALT5 Gene

  1. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. (PMID: 9597550) Lo N.-W. … Shaper N.L. (Glycobiology 1998) 2 3 4 67
  2. Molecular cloning of a human cDNA encoding beta-1,4- galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase. (PMID: 9435216) Sato T. … van Die I. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for B4GALT5 Gene

Sources for B4GALT5 Gene

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