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Aliases for B4GALT5 Gene

Aliases for B4GALT5 Gene

  • Beta-1,4-Galactosyltransferase 5 2 3 5
  • UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,4-Galactosyltransferase 5 3 4
  • UDP-Gal:Beta-GlcNAc Beta-1,4-Galactosyltransferase 5 3 4
  • Beta-1,4-GalTase 5 3 4
  • Beta-1,4-GalT II 3 4
  • Beta4-GalT IV 2 3
  • Beta4Gal-T5 3 4
  • B4Gal-T5 3 4
  • UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 5 2
  • UDP-Gal:BetaGlcNAc Beta 1,4-Galactosyltransferase, Polypeptide 5 3
  • Beta-1.4-Galactosyltransferase V 3
  • Beta-1,4-GalT IV 3
  • Beta4GalT-V 3
  • EC 2.4.1.- 4
  • Gt-V 3

External Ids for B4GALT5 Gene

Previous GeneCards Identifiers for B4GALT5 Gene

  • GC20M047977
  • GC20M048887
  • GC20M048935
  • GC20M048936
  • GC20M047682
  • GC20M048249
  • GC20M044999

Summaries for B4GALT5 Gene

Entrez Gene Summary for B4GALT5 Gene

  • This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. [provided by RefSeq, Jul 2008]

GeneCards Summary for B4GALT5 Gene

B4GALT5 (Beta-1,4-Galactosyltransferase 5) is a Protein Coding gene. Diseases associated with B4GALT5 include Pharynx Cancer and Kidney Leiomyosarcoma. Among its related pathways are N-glycan antennae elongation in the medial/trans-Golgi and Keratan sulfate/keratin metabolism. GO annotations related to this gene include galactosyltransferase activity. An important paralog of this gene is B4GALT6.

UniProtKB/Swiss-Prot for B4GALT5 Gene

  • Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Gene Wiki entry for B4GALT5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B4GALT5 Gene

Genomics for B4GALT5 Gene

Regulatory Elements for B4GALT5 Gene

Enhancers for B4GALT5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G050140 2.1 FANTOM5 Ensembl ENCODE dbSUPER 22.1 -433.8 -433836 14.1 CREB3L1 ZFP64 DMAP1 YBX1 YY1 ZNF143 NFYC TBX21 SSRP1 GLIS1 SNAI1 SLC9A8 LINC01273 B4GALT5 PTPN1 CEBPB TMEM189 RNF114 TMEM189-UBE2V1 UBE2V1
GH20G049698 2 FANTOM5 Ensembl ENCODE dbSUPER 21.4 +13.0 12983 5.8 HDGF PKNOX1 WRNIP1 SIN3A ZNF207 FOS DEK ZNF263 JUNB REST SLC9A8 SNAI1 B4GALT5 ZNFX1 CEBPB TMEM189 RNF114 GC20M049705 GC20M049629
GH20G049275 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +433.9 433930 9.2 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 CSE1L ZNFX1 ZFAS1 SNORD12B B4GALT5 SNORD12 ARFGEF2 ENSG00000274760 GC20P049304
GH20G049793 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.3 -80.5 -80455 2.2 ELF3 HDGF PKNOX1 NFIB YBX1 ELK1 ZNF207 RCOR1 CEBPB ZNF623 SLC9A8 SNAI1 B4GALT5 CEBPB TMEM189 RNF114 GC20P049796 LOC105372652
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around B4GALT5 on UCSC Golden Path with GeneCards custom track

Promoters for B4GALT5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for B4GALT5 Gene

49,632,945 bp from pter
49,713,884 bp from pter
80,940 bases
Minus strand

Genomic View for B4GALT5 Gene

Genes around B4GALT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
B4GALT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for B4GALT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B4GALT5 Gene

Proteins for B4GALT5 Gene

  • Protein details for B4GALT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-1,4-galactosyltransferase 5
    Protein Accession:
    Secondary Accessions:
    • E1P625
    • Q2M394
    • Q9UJQ8

    Protein attributes for B4GALT5 Gene

    388 amino acids
    Molecular mass:
    45119 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for B4GALT5 Gene

Post-translational modifications for B4GALT5 Gene

  • Glycosylation at Thr59, posLast=7777, Asn81, posLast=9090, posLast=111111, posLast=128128, posLast=364364, and posLast=373373
  • Modification sites at PhosphoSitePlus

Other Protein References for B4GALT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for B4GALT5 Gene

Domains & Families for B4GALT5 Gene

Gene Families for B4GALT5 Gene

Suggested Antigen Peptide Sequences for B4GALT5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 7 family.
  • Belongs to the glycosyltransferase 7 family.
genes like me logo Genes that share domains with B4GALT5: view

Function for B4GALT5 Gene

Molecular function for B4GALT5 Gene

GENATLAS Biochemistry:
UDP galactose
UniProtKB/Swiss-Prot Function:
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Enzyme Numbers (IUBMB) for B4GALT5 Gene

Gene Ontology (GO) - Molecular Function for B4GALT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity TAS --
GO:0008378 galactosyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with B4GALT5: view
genes like me logo Genes that share phenotypes with B4GALT5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for B4GALT5

CRISPR Products

miRNA for B4GALT5 Gene

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for B4GALT5 Gene

Localization for B4GALT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B4GALT5 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for B4GALT5 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 2
mitochondrion 2
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for B4GALT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with B4GALT5: view

Pathways & Interactions for B4GALT5 Gene

genes like me logo Genes that share pathways with B4GALT5: view

Pathways by source for B4GALT5 Gene

UniProtKB/Swiss-Prot O43286-B4GT5_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for B4GALT5 Gene

Gene Ontology (GO) - Biological Process for B4GALT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006486 protein glycosylation IEA --
GO:0016266 O-glycan processing TAS --
GO:0018146 keratan sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with B4GALT5: view

No data available for SIGNOR curated interactions for B4GALT5 Gene

Drugs & Compounds for B4GALT5 Gene

(1) Drugs for B4GALT5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 34
genes like me logo Genes that share compounds with B4GALT5: view

Transcripts for B4GALT5 Gene

mRNA/cDNA for B4GALT5 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(335) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for B4GALT5 Gene

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for B4GALT5 Gene

No ASD Table

Relevant External Links for B4GALT5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for B4GALT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for B4GALT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B4GALT5 Gene

This gene is overexpressed in Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for B4GALT5 Gene

This gene is overexpressed in Milk (24.6) and Urine (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for B4GALT5 Gene

NURSA nuclear receptor signaling pathways regulating expression of B4GALT5 Gene:


SOURCE GeneReport for Unigene cluster for B4GALT5 Gene:


mRNA Expression by UniProt/SwissProt for B4GALT5 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for B4GALT5 Gene

  • Nervous system(4.7)
  • Lung(4.6)
  • Intestine(2.5)
  • Lymph node(2.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with B4GALT5: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for B4GALT5 Gene

Orthologs for B4GALT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for B4GALT5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia B4GALT5 34 35
  • 99.48 (n)
(Monodelphis domestica)
Mammalia B4GALT5 35
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia B4GALT5 35
  • 93 (a)
(Canis familiaris)
Mammalia B4GALT5 34 35
  • 92 (n)
(Bos Taurus)
Mammalia B4GALT5 34 35
  • 89.73 (n)
(Mus musculus)
Mammalia B4galt5 34 16 35
  • 86.82 (n)
(Gallus gallus)
Aves B4GALT5 34 35
  • 82.82 (n)
(Anolis carolinensis)
Reptilia B4GALT5 35
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia b4galt6 34
  • 75.42 (n)
(Danio rerio)
Actinopterygii b4galt5 34 35
  • 66.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH13356 36
  • 38 (a)
CG14517 36
  • 38 (a)
beta4GalT7 35
  • 25 (a)
(Caenorhabditis elegans)
Secernentea W02B12.11 36 34
  • 46.86 (n)
Y73E7A.7 36
  • 41 (a)
sqv-3 35
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
Species where no ortholog for B4GALT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for B4GALT5 Gene

Gene Tree for B4GALT5 (if available)
Gene Tree for B4GALT5 (if available)

Paralogs for B4GALT5 Gene

Paralogs for B4GALT5 Gene

(5) SIMAP similar genes for B4GALT5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B4GALT5: view

Variants for B4GALT5 Gene

Sequence variations from dbSNP and Humsavar for B4GALT5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000049696 -- 49,669,653(+) ATCGC(A/G)CCATT intron-variant
rs1000084383 -- 49,711,406(+) TTTCT(A/G)TCAAA intron-variant
rs1000121948 -- 49,647,627(+) GATGC(C/T)GCTGT intron-variant
rs1000147848 -- 49,689,665(+) CTAAA(C/T)ACTTC intron-variant
rs1000162124 -- 49,644,206(+) ACAGT(C/T)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for B4GALT5 Gene

Variant ID Type Subtype PubMed ID
esv3646017 CNV gain 21293372
esv3646018 CNV gain 21293372
esv3646019 CNV loss 21293372
esv3646020 CNV gain 21293372
esv3646021 CNV gain 21293372
nsv1065418 CNV gain 25217958
nsv1065852 CNV loss 25217958
nsv819562 CNV loss 19587683
nsv954056 CNV duplication 24416366

Variation tolerance for B4GALT5 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.15; 69.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for B4GALT5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for B4GALT5 Gene

Disorders for B4GALT5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for B4GALT5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pharynx cancer
  • pharyngeal cancer
kidney leiomyosarcoma
  • leiomyosarcoma of kidney
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for B4GALT5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with B4GALT5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for B4GALT5 Gene

Publications for B4GALT5 Gene

  1. Molecular cloning of a human cDNA encoding beta-1,4- galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase. (PMID: 9435216) Sato T. … van Die I. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 64
  2. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. (PMID: 9597550) Lo N.-W. … Shaper N.L. (Glycobiology 1998) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PMID: 10580128) Amado M. … Clausen H. (Biochim. Biophys. Acta 1999) 3 4 64

Products for B4GALT5 Gene

Sources for B4GALT5 Gene

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