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Aliases for B4GALT5 Gene

Aliases for B4GALT5 Gene

  • UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 5 2 3
  • UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,4-Galactosyltransferase 5 3 4
  • UDP-Gal:Beta-GlcNAc Beta-1,4-Galactosyltransferase 5 3 4
  • Beta-1,4-GalTase 5 3 4
  • Beta-1,4-GalT II 3 4
  • Beta4-GalT IV 2 3
  • Beta4Gal-T5 3 4
  • B4Gal-T5 3 4
  • UDP-Gal:BetaGlcNAc Beta 1,4-Galactosyltransferase, Polypeptide 5 3
  • Beta-1,4-Galactosyltransferase 5 3
  • Beta-1.4-Galactosyltransferase V 3
  • Beta-1,4-GalT IV 3
  • BETA4-GALT-IV 3
  • Beta4GalT-V 3
  • EC 2.4.1.- 4
  • Gt-V 3

External Ids for B4GALT5 Gene

Summaries for B4GALT5 Gene

Entrez Gene Summary for B4GALT5 Gene

  • This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. [provided by RefSeq, Jul 2008]

GeneCards Summary for B4GALT5 Gene

B4GALT5 (UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 5) is a Protein Coding gene. Diseases associated with B4GALT5 include nasopharynx carcinoma. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include galactosyltransferase activity. An important paralog of this gene is B4GALT7.

UniProtKB/Swiss-Prot for B4GALT5 Gene

  • Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Gene Wiki entry for B4GALT5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for B4GALT5 Gene

Genomics for B4GALT5 Gene

Genomic Location for B4GALT5 Gene

Start:
49,632,945 bp from pter
End:
49,713,884 bp from pter
Size:
80,940 bases
Orientation:
Minus strand

Genomic View for B4GALT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for B4GALT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for B4GALT5 Gene

Regulatory Elements for B4GALT5 Gene

Proteins for B4GALT5 Gene

  • Protein details for B4GALT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43286-B4GT5_HUMAN
    Recommended name:
    Beta-1,4-galactosyltransferase 5
    Protein Accession:
    O43286
    Secondary Accessions:
    • E1P625
    • Q2M394
    • Q9UJQ8

    Protein attributes for B4GALT5 Gene

    Size:
    388 amino acids
    Molecular mass:
    45119 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for B4GALT5 Gene

Proteomics data for B4GALT5 Gene at MOPED

Post-translational modifications for B4GALT5 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr59, Asn77, Asn81, Asn90, Asn111, Asn128, Asn364, and Asn373

Other Protein References for B4GALT5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for B4GALT5 Gene

Domains for B4GALT5 Gene

Gene Families for B4GALT5 Gene

HGNC:
  • B4GT :Beta 4-glycosyltransferases

UniProtKB/Swiss-Prot:

B4GT5_HUMAN
Family:
  • Belongs to the glycosyltransferase 7 family.:
    • O43286
genes like me logo Genes that share domains with B4GALT5: view

Function for B4GALT5 Gene

Molecular function for B4GALT5 Gene

GENATLAS Biochemistry: UDP galactose
UniProtKB/Swiss-Prot Function: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Enzyme Numbers (IUBMB) for B4GALT5 Gene

Gene Ontology (GO) - Molecular Function for B4GALT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008378 galactosyltransferase activity TAS 9597550
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with B4GALT5: view
genes like me logo Genes that share phenotypes with B4GALT5: view

miRNA for B4GALT5 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for B4GALT5 Gene

Localization for B4GALT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for B4GALT5 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for B4GALT5 Gene COMPARTMENTS Subcellular localization image for B4GALT5 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
cytosol 1
extracellular 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for B4GALT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with B4GALT5: view

Pathways for B4GALT5 Gene

genes like me logo Genes that share pathways with B4GALT5: view

Pathways by source for B4GALT5 Gene

1 KEGG pathway for B4GALT5 Gene

UniProtKB/Swiss-Prot O43286-B4GT5_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for B4GALT5 Gene

Gene Ontology (GO) - Biological Process for B4GALT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with B4GALT5: view

Compounds for B4GALT5 Gene

(1) HMDB Compounds for B4GALT5 Gene

Compound Synonyms Cas Number PubMed IDs
Manganese
  • manganese
7439-96-5
genes like me logo Genes that share compounds with B4GALT5: view

Transcripts for B4GALT5 Gene

mRNA/cDNA for B4GALT5 Gene

Unigene Clusters for B4GALT5 Gene

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for B4GALT5 Gene

No ASD Table

Relevant External Links for B4GALT5 Gene

GeneLoc Exon Structure for
B4GALT5
ECgene alternative splicing isoforms for
B4GALT5

Expression for B4GALT5 Gene

mRNA expression in normal human tissues for B4GALT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for B4GALT5 Gene

This gene is overexpressed in Whole Blood (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for B4GALT5 Gene

SOURCE GeneReport for Unigene cluster for B4GALT5 Gene Hs.370487

mRNA Expression by UniProt/SwissProt for B4GALT5 Gene

O43286-B4GT5_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with B4GALT5: view

Orthologs for B4GALT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for B4GALT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia B4GALT5 36
  • 99.48 (n)
  • 99.74 (a)
B4GALT5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia B4GALT5 36
  • 89.73 (n)
  • 96.22 (a)
B4GALT5 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia B4GALT5 36
  • 92 (n)
  • 96.57 (a)
B4GALT5 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B4galt5 36
  • 86.82 (n)
  • 94.71 (a)
B4galt5 16
B4galt5 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia B4GALT5 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia B4GALT5 37
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves B4GALT5 36
  • 82.82 (n)
  • 91.36 (a)
B4GALT5 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia B4GALT5 37
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia b4galt6 36
  • 75.42 (n)
  • 83.24 (a)
zebrafish
(Danio rerio)
Actinopterygii b4galt5 36
  • 66.85 (n)
  • 71.19 (a)
b4galt5 37
  • 70 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta beta4GalT7 37
  • 25 (a)
OneToMany
BcDNA:GH13356 38
  • 38 (a)
CG14517 38
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea sqv-3 37
  • 23 (a)
OneToMany
W02B12.11 36
  • 46.86 (n)
  • 38.36 (a)
Y73E7A.7 38
  • 41 (a)
W02B12.11 38
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
OneToMany
Species with no ortholog for B4GALT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for B4GALT5 Gene

ENSEMBL:
Gene Tree for B4GALT5 (if available)
TreeFam:
Gene Tree for B4GALT5 (if available)

Paralogs for B4GALT5 Gene

Paralogs for B4GALT5 Gene

Selected SIMAP similar genes for B4GALT5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with B4GALT5: view

Variants for B4GALT5 Gene

Sequence variations from dbSNP and Humsavar for B4GALT5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs12084 -- 49,633,744(+) TCAAA(A/C)AAGAT utr-variant-3-prime
rs16433 -- 49,633,439(-) AAAAA(A/C)AAAAC utr-variant-3-prime
rs235032 -- 49,634,210(+) ACAAA(A/C)AAAAC utr-variant-3-prime
rs235033 -- 49,634,694(+) ACCCC(C/T)GTCTC utr-variant-3-prime
rs235034 -- 49,635,801(-) TTTTT(A/T)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for B4GALT5 Gene

Variant ID Type Subtype PubMed ID
nsv819562 CNV Loss 19587683

Relevant External Links for B4GALT5 Gene

HapMap Linkage Disequilibrium report
B4GALT5

Disorders for B4GALT5 Gene

(1) MalaCards Diseases for B4GALT5 Gene

Search for B4GALT5 Gene in MalaCards »

(3) University of Copenhagen DISEASES for B4GALT5 Gene

genes like me logo Genes that share disorders with B4GALT5: view

No data available for UniProtKB/Swiss-Prot for B4GALT5 Gene

Publications for B4GALT5 Gene

  1. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. (PMID: 9597550) Lo N.-W. … Shaper N.L. (Glycobiology 1998) 2 3 4
  2. Molecular cloning of a human cDNA encoding beta-1,4- galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase. (PMID: 9435216) Sato T. … van Die I. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  3. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PMID: 10580128) Amado M. … Clausen H. (Biochim. Biophys. Acta 1999) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for B4GALT5 Gene

Sources for B4GALT5 Gene

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