Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

B4GALT5 Gene

protein-coding   GIFtS: 59
GCID: GC20M048249

UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 51 2     Beta-1,4-GalT IV2
Beta4-GalT IV1 2     Beta-1.4-Galactosyltransferase V2
Beta-1,4-GalT II2 3     beta4Gal-T52
Beta-1,4-GalTase 52 3     beta4GalT-V2
UDP-Gal:Beta-GlcNAc Beta-1,4-Galactosyltransferase 52 3     gt-V2
UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,4-Galactosyltransferase 52 3     UDP-Gal:BetaGlcNAc Beta 1,4-Galactosyltransferase, Polypeptide 52
B4Gal-T52     Beta4Gal-T53
BETA4-GALT-IV2     EC 2.4.1.-3
Beta-1,4-Galactosyltransferase 52     b4Gal-T53

External Ids:    HGNC: 9281   Entrez Gene: 93342   Ensembl: ENSG000001584707   OMIM: 6040165   UniProtKB: O432863   

Export aliases for B4GALT5 gene to outside databases

Previous GC identifers: GC20M047977 GC20M048887 GC20M048935 GC20M048936 GC20M047682 GC20M044999


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for B4GALT5 Gene:
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound
glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer
galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct
function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane
proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and
which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form
four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The
function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was
renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. (provided by RefSeq, Jul 2008)

GeneCards Summary for B4GALT5 Gene: 
B4GALT5 (UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5) is a protein-coding gene. Diseases associated with B4GALT5 include nasopharynx carcinoma, and morquio syndrome b, and among its related super-pathways are Mucin type O-Glycan biosynthesis and Metabolism of carbohydrates. GO annotations related to this gene include galactosyltransferase activity and metal ion binding. An important paralog of this gene is B4GALT2.

UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286
Function: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as
the carbohydrate moieties of glycolipids

Gene Wiki entry for B4GALT5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the B4GALT5 gene promoter:
         HOXA9B   HOXA9   Spz1   Pax-5   Egr-1   AP-4   Meis-1b   HEN1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidB4GALT5 promoter sequence
   Search SABiosciences Chromatin IP Primers for B4GALT5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat B4GALT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1-q13.2   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.1-q13.2

B4GALT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
B4GALT5 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M048249:  view genomic region     (about GC identifiers)

Start:
48,249,482 bp from pter      End:
48,330,421 bp from pter
Size:
80,940 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286 (See protein sequence)
Recommended Name: Beta-1,4-galactosyltransferase 5  
Size: 388 amino acids; 45119 Da
Cofactor: Manganese (By similarity)
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans
cisternae of Golgi stack
Secondary accessions: E1P625 Q2M394 Q9UJQ8

Explore the universe of human proteins at neXtProt for B4GALT5: NX_O43286

Explore proteomics data for B4GALT5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43286

  • B4GALT5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    B4GALT5 Protein Expression
    REFSEQ proteins: NP_004767.1  
    ENSEMBL proteins: 
     ENSP00000360776  
    Reactome Protein details: O43286
    Human Recombinant Protein Products for B4GALT5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for B4GALT5
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for B4GALT5
    GenScript Custom Purified and Recombinant Proteins Services for B4GALT5
    Novus Biologicals B4GALT5 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--

    B4GALT5 for ontologies           About GeneDecksing



    B4GALT5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for B4GALT5
    GenScript Custom Superior Antibodies Services for B4GALT5
    Novus Biologicals B4GALT5 Antibodies
    Abcam antibodies for B4GALT5
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for B4GALT5
    LSBio Antibodies in human, mouse, rat for B4GALT5 

    Assay Products for B4GALT5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for B4GALT5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for B4GALT5
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    B4GT: Beta 4-glycosyltransferases

    1 InterPro protein domain:
     IPR003859 Galactosyl_T_2_met

    Graphical View of Domain Structure for InterPro Entry O43286

    ProtoNet protein and cluster: O43286

    1 Blocks protein domain: IPB003859 Metazoa galactosyltransferase

    UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286
    Similarity: Belongs to the glycosyltransferase 7 family


    B4GALT5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: B4GT5_HUMAN, O43286
    Function: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as
    the carbohydrate moieties of glycolipids

         Genatlas biochemistry entry for B4GALT5:
    UDP galactose

         Enzyme Number (IUBMB): EC 2.4.1.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008378galactosyltransferase activity TAS9597550
    GO:0016757transferase activity, transferring glycosyl groups ----
    GO:0046872metal ion binding IEA--
         
    B4GALT5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for B4GALT5:
     Decreased viability of wild-ty  Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for B4galt5):
     behavior/neurological  embryogenesis  growth/size  homeostasis/metabolism  mortality/aging 

    B4GALT5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for B4GALT5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for B4GALT5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for B4GALT5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for B4GALT5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat B4GALT5
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate B4GALT5 (see all 68):
    hsa-miR-30d hsa-miR-502-3p hsa-miR-30a hsa-miR-376a* hsa-miR-3148 hsa-miR-130b hsa-miR-2113 hsa-miR-3688-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for B4GALT5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat B4GALT5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for B4GALT5
    Sirion Biotech Customized adenovirus for overexpression of B4GALT5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for B4GALT5 (see all 7)
    OriGene ORF clones in mouse, rat for B4GALT5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: B4GALT5 (NM_004776)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for B4GALT5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B4GALT5
    Sirion Biotech Customized lentivirus for stable overexpression of B4GALT5 
                         Customized lentivirus expression plasmids for stable overexpression of B4GALT5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for B4GALT5
    Search LifeMap BioReagents cell lines for B4GALT5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B4GALT5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for B4GALT5 About   (see all 9)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1O-linked glycosylation of mucins
    O-linked glycosylation of mucins0.44
    Mucin type O-Glycan biosynthesis0.44
    2MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Glycosaminoglycan metabolism0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS I - Hurler syndrome0.48
    MPS IV - Morquio syndrome B0.48
    MPS IX - Natowicz syndrome0.48
    3Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    Post-translational protein modification0.44
    WNT ligand biogenesis and trafficking0.77
    Metabolism of proteins0.35
    Signaling by Wnt0.62
    4N-glycan antennae elongation in the medial/trans-Golgi
    N-glycan antennae elongation in the medial/trans-Golgi0.75
    Transport to the Golgi and subsequent modification0.56
    N-Glycan antennae elongation0.75
    5Keratan sulfate biosynthesis
    Keratan sulfate biosynthesis0.82
    Keratan sulfate/keratin metabolism0.82

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for B4GALT5
        Sperm Motility

    5/28        Reactome Pathways for B4GALT5 (see all 28)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    Keratan sulfate/keratin metabolism
    Transport to the Golgi and subsequent modification


    1         Kegg Pathway  (Kegg details for B4GALT5):
        Mucin type O-Glycan biosynthesis

    UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286
    Pathway: Protein modification; protein glycosylation


    B4GALT5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for B4GALT5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/17 Interacting proteins for B4GALT5 (ENSP000003607764) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    GCNT1ENSP000003659204STRING: ENSP00000365920
    MUC1ENSP000003389834STRING: ENSP00000338983
    MUC12ENSP000003687554STRING: ENSP00000368755
    MUC13ENSP000003122354STRING: ENSP00000312235
    MUC15ENSP000004167534STRING: ENSP00000416753
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0016266O-glycan processing TAS--
    GO:0018146keratan sulfate biosynthetic process TAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--

    B4GALT5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for B4GALT5 (B4GT5)

    1 HMDB Compound for B4GALT5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Manganesemanganese 7439-96-5--

    Search CenterWatch for drugs/clinical trials and news about B4GALT5 / B4GT5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for B4GALT5 gene: 
    NM_004776.3  

    Unigene Cluster for B4GALT5:

    UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
    Hs.370487  [show with all ESTs]
    Unigene Representative Sequence: NM_004776
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371711(uc002xuu.4)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat B4GALT5
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate B4GALT5 (see all 68):
    hsa-miR-30d hsa-miR-502-3p hsa-miR-30a hsa-miR-376a* hsa-miR-3148 hsa-miR-130b hsa-miR-2113 hsa-miR-3688-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for B4GALT5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat B4GALT5
    Clone
    Products:
         
    OriGene clones in human, mouse for B4GALT5 (see all 7)
    OriGene ORF clones in mouse, rat for B4GALT5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: B4GALT5 (NM_004776)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for B4GALT5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B4GALT5
    Sirion Biotech Customized lentivirus for stable overexpression of B4GALT5 
                         Customized lentivirus expression plasmids for stable overexpression of B4GALT5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for B4GALT5
    OriGene qSTAR qPCR primer pairs in human, mouse for B4GALT5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat B4GALT5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat B4GALT5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat B4GALT5

    Additional mRNA sequence: 

    AB004550.1 AF038663.1 AF289556.1 AK054803.1 AK056333.1 BC074821.2 BC074873.2 BC104987.1 
    BC112265.1 

    5 DOTS entries:

    DT.451617  DT.87017400  DT.95134284  DT.87017870  DT.91719572 

    24/335 AceView cDNA sequences (see all 335):

    BU674762 AI192239 AI923994 AI085327 AW026697 BX509324 BU727476 BF477527 
    AI122984 AI219311 AI151021 AI924160 AI818828 BE858968 BX505289 AA399293 
    AI494533 AA551055 AA223526 AA292088 AI147095 BX499835 CD674125 AI078366 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    B4GALT5 expression in normal human tissues (normalized intensities)      B4GALT5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTGTACA
    B4GALT5 Expression
    About this image


    B4GALT5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             retinal progenitor cell e16.5   
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Blood (Hematopoietic System)

    See B4GALT5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for B4GALT5

    SOURCE GeneReport for Unigene cluster: Hs.370487

    UniProtKB/Swiss-Prot: B4GT5_HUMAN, O43286
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Array including B4GALT5: 
              Glycosylation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for B4GALT5
    OriGene qSTAR qPCR primer pairs in human, mouse for B4GALT5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat B4GALT5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat B4GALT5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat B4GALT5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B4GALT5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for B4GALT5 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia B4galt51 , 5 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, more1, 5 87.46(n)1
    95.1(a)1
      2 (87.22 cM)5
    563361  NM_019835.21  NP_062809.21 
     1672984445 
    chicken
    (Gallus gallus)
    Aves B4GALT51 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, more 82.26(n)
    90.18(a)
      419358  XM_417519.3  XP_417519.3 
    lizard
    (Anolis carolinensis)
    Reptilia B4GALT56
    UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase...
    88(a)
    1 ↔ 1
    4(146953371-147030925)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL888833.22   -- 78.96(n)    AL888833.2 
    zebrafish
    (Danio rerio)
    Actinopterygii b4galt51 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, more 66.22(n)
    70.74(a)
      724080  NM_001045332.1  NP_001038797.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG145173 UDP-galactose-glucosylceramide
    beta-1,4-galactosyltransferase
    38(a)
    (best of 2)
      98F5   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y73E7A.73
    W02B12.111
    Protein W02B12.111 41(a)
    (best of 2)3
    45.65(n)1
    36.68(a)1
      I(1621527-1626606)3
    1747541  NM_064048.41  NP_496449.11 


    ENSEMBL Gene Tree for B4GALT5 (if available)
    TreeFam Gene Tree for B4GALT5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for B4GALT5 gene
    B4GALT22  B4GALT42  B4GALT12  B4GALT72  B4GALT62  B4GALT32  
    5 SIMAP similar genes for B4GALT5 using alignment to 1 protein entry:     B4GT5_HUMAN:
    B4GALT6    B4GALT1    B4GALT4    B4GALT3    B4GALT2

    B4GALT5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1763 SNPs in B4GALT5 are shown (see all 1763)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739105781,2
    C,F--48249090(+) GATGAC/TAATCT 1 -- int12Minor allele frequency- T:0.10WA 120
    rs1398227961,2
    --48249140(+) GAGAAA/CCTTCT 1 -- int10--------
    rs1453706571,2
    --48249259(+) CCAAGC/TGTGGG 1 -- int10--------
    rs1167264331,2
    C,F--48249307(+) CACTGC/TGTAGC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1477370761,2
    --48249308(+) ACTGCA/GTAGCT 1 -- int10--------
    rs757925201,2
    C--48249311(+) GCGTAG/TCTTTT 1 -- int10--------
    rs61228001,2
    C--48249382(+) CTCAGC/ATGAGC 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1891501371,2
    --48249404(+) GAACTA/CCTGTA 1 -- int10--------
    rs1810874461,2
    --48249407(+) CTCCTG/TTAGGA 1 -- int10--------
    rs1865911951,2
    --48249639(+) TACCCC/TTGGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for B4GALT5 (48249482 - 48330421 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for B4GALT5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv819562CNV Loss19587683

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing B4GALT5
    DNA2.0 Custom Variant and Variant Library Synthesis for B4GALT5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604016    OMIM disorders: --

    3 diseases for B4GALT5:    About MalaCards
    nasopharynx carcinoma    morquio syndrome b    astrocytoma

    3 diseases from the University of Copenhagen DISEASES database for B4GALT5:
    Lung cancer     Cervical cancer     Nasopharynx carcinoma

    B4GALT5 for disorders           About GeneDecksing


    Export disorders for B4GALT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for B4GALT5 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with B4GALT5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. (PubMed id 9597550)1, 2, 3 Lo N.-W.... Shaper N.L. (1998)
    2. Molecular cloning of a human cDNA encoding beta-1,4- galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase. (PubMed id 9435216)1, 2, 3 Sato T.... van Die I. (1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. (PubMed id 10580128)1, 2 Amado M.... Clausen H. (1999)
    6. Genome-wide association study identifies novel loci as sociated with concentrations of four plasma phospholipid fatty acids in the de n ovo lipogenesis pathway: results from the Cohorts for Heart and Aging Research i n Genomic Epidemiology (CHARGE) consortium. (PubMed id 23362303)1 Wu J.H....Mozaffarian D. (2013)
    7. [Regulation of human b-1,4-galactosyltransferase V gen e expression in cancer cells]. (PubMed id 22687727)1 Sato T. and Furukawa K. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Beta1,4-galactosyltransferase V regulates self-renewa l of glioma-initiating cell. (PubMed id 20417617)1 Wei Y....Jiang J. (2010)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9334 HGNC: 928 AceView: B4GALT5 Ensembl:ENSG00000158470 euGenes: HUgn9334
    ECgene: B4GALT5 Kegg: 9334 H-InvDB: B4GALT5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for B4GALT5 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_440

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for B4GALT5 gene:
    Search GeneIP for patents involving B4GALT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for B4GALT5  
     OriGene qPCR primer pairs and template standards for B4GALT5   OriGene Protein Over-expression Lysate for B4GALT5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for B4GALT5  
     OriGene qSTAR qPCR primer pairs in human, mouse for B4GALT5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for B4GALT5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for B4GALT5   OriGene Custom Protein Services for B4GALT5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat B4GALT5
     QIAGEN SeqTarget long-range PCR primers for resequencing B4GALT5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat B4GALT5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat B4GALT5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat B4GALT5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat B4GALT5
     GenScript Custom Purified and Recombinant Proteins Services for B4GALT5 GenScript cDNA clones with any tag delivered in your preferred vector for B4GALT5
     GenScript Custom Assay Services for B4GALT5 GenScript Custom Superior Antibodies Services for B4GALT5
     GenScript Custom overexpressing Cell Line Services for B4GALT5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in B4GALT5 promoter
     Search Chromatin IP Primers for B4GALT5
     RT2 qPCR Primer Assay in human, mouse, rat B4GALT5
     Search GNC Networks for B4GALT5
     SABiosciences PCR Arrays including human, mouse, rat B4GALT5
     Search Tocris compounds for B4GALT5 (B4GT5)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     B4GALT5 antibodies
     B4GALT5 proteins
     Antibodies for B4GALT5
     See all of Abcam's Antibodies, Kits and Proteins for B4GALT5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for B4GALT5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for B4GALT5
     Browse SwitchGear 3'UTR luciferase reporter plasmids for B4GALT5
     SwitchGear Promoter luciferase reporter plasmids for B4GALT5
     ThermoFisher Antibodies for B4GALT5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat B4GALT5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for B4GALT5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for B4GALT5
    Customized:
     lentivirus for stable overexpression of B4GALT5
     lentivirus expression plasmids for stable overexpression of B4GALT5
     adenovirus for overexpression of B4GALT5
     LSBio Antibodies in human, mouse, rat for B4GALT5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      B4GALT5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4